TW201807125A - Pressure sensitive adhesive sheet having release liner - Google Patents

Abstract

To provide a pressure sensitive adhesive sheet having a release liner, being a pressure sensitive adhesive sheet for a test piece for analyzing a specimen. The pressure sensitive adhesive sheet having a release liner includes: a double-sided pressure sensitive adhesive sheet having adhesive layers; a first release liner covering the first adhesive layer of the pressure sensitive adhesive sheet; and a second release liner covering the second adhesive layer of the pressure sensitive adhesive sheet. A water contact angle is 70 DEG or more with regard to one of a back face of the first release liner and a back face of the second release liner.

Description

Adhesive sheet with release liner

The present invention relates to an adhesive sheet with a release liner for manufacturing a test piece for analyzing a sample.

Various sample measurement equipment for measuring blood glucose concentration and the like are widely used in the industry. The measurement using such a device is performed, for example, by sampling a blood sample or the like on a test piece, and placing the test piece holding the sample in the measuring device, and detecting when a reagent in the test piece reacts with the sample. The current etc. As a prior art document which discloses the test piece used for the said measuring apparatus, the Japanese patent application publication 2006-308458 is mentioned. Japanese Patent Application Publication No. 2015-054921 is a prior art document related to an adhesive sheet used for such a test piece.

The test piece includes, for example, a plurality of members such as a substrate, a spacer, and a cover (for example, a hydrophilic film). In order to bond the substrate to the cover, a double-sided adhesive sheet (double-sided adhesive sheet) is preferably used. The double-sided adhesive sheet also functions as a spacer between the substrate and the cover, and has a path (also referred to as a capillary) for guiding the sample to the electrode. In addition, a hole is provided in the double-sided adhesive sheet for injecting a reagent reacting with a sample such as blood, and after one of the double-sided adhesive sheets is adhered to a substrate, the reagent is injected into the double-sided adhesive sheet. hole. After that, a test piece is manufactured by attaching the cover to the other adhesive surface of the double-sided adhesive sheet and joining the substrate and the cover. In the manufacture of the test piece as described above, the accuracy of injecting the reagent into the hole provided in the above-mentioned adhesive sheet may not be able to inject at least a part of the reagent into the hole, resulting in poor injection. In this case, the test piece can be effectively used by re-injecting the reagent to the test piece having a poor injection. However, for example, reagents used for blood glucose concentration measurement often include enzymes and are expensive, so there are cases where it is necessary to avoid reinjection. That is, when it is convenient to cause the injection failure as described above, as long as the remaining reagents that have not been injected into the wells can be injected into the required wells through subsequent operations, the loss of reagents can also be avoided, which is beneficial. The present invention has been made in view of the foregoing circumstances, and an object thereof is to provide an adhesive sheet with a release liner, which is an adhesive sheet for a test piece for analyzing a sample, and can prevent loss of reagents during the manufacture of the test piece. [Technical means to solve the problem] According to the present invention, there is provided an adhesive sheet with a release liner for producing a test piece for analyzing a sample. The adhesive sheet with a release liner includes a double-sided adhesive sheet having an adhesive layer, a first release liner covering a first adhesive surface of the adhesive sheet, and a second adhesive sheet covering a second adhesive surface of the adhesive sheet. 2 Release liner. The water contact angle of one of the back surface of the first release liner and the back surface of the second release liner is 70 ° or more. According to the above configuration, the double-sided adhesive sheet covers its two adhesive surfaces with two release liners, respectively. Therefore, it is possible to easily form a through release liner (for example, a second release liner) in a state of an adhesive sheet with a release liner. Pad) and the hole of the adhesive sheet. In addition, when a test piece (hereinafter, also referred to as a "test piece") for analyzing a sample is manufactured, the first release liner protecting the first adhesive surface of the double-sided adhesive sheet can be peeled off, and the exposed first 1 After the adhesive surface is bonded to the substrate, the reagent is injected into the hole opened in the rear surface from the back (outer surface) side of the second release liner that protects the second adhesive surface. In addition, even if the reagent cannot be injected into the hole with high accuracy during the injection of the reagent, at least a part of the reagent is left on the back surface of the second release liner and injection failure occurs. The contact angle was set to 70 ° or more, and it remained on the back surface of the second release liner without injecting any reagent. By inducing an uninjected reagent on the back surface of the second release liner into the well by an appropriate method, the reagent can be used without waste. In contrast to the above, when the second adhesive surface is first attached to the adherend, the same effect as described above can be obtained by setting the water contact angle on the back surface of the first release liner to 70 ° or more. Therefore, by using the adhesive sheet with a release liner of the present invention, it is possible to prevent loss of reagents during the production of the test piece. In a preferred aspect of the technology disclosed here (including an adhesive sheet with a release liner, a test piece provided with the adhesive sheet, and a method for manufacturing the test piece, the same below), the gel fraction of the above-mentioned adhesive layer is The rate is 25% to 55%. The above-mentioned gel fraction is excellent in the reagent holding property of an adhesive sheet having a specific value or less. Specifically, by reducing the gel fraction of the adhesive layer to a specific value or less, it is possible to better prevent the reagent contained in the double-sided adhesive sheet from leaking from the adhesive surface of the adhesive sheet. In addition, since the adhesive sheet having the gel fraction above a specific value has no paste overflow after processing such as punching, the processability is excellent. Furthermore, by using an adhesive layer having a gel fraction in the above range, the bending resistance can be improved. In a preferred aspect of the technology disclosed herein, the adhesive surface of the above-mentioned adhesive sheet (typically, both the first adhesive surface and the second adhesive surface) shows a 180-degree peel of 7 N / 20 mm or more strength. The adhesive sheet exhibiting the above-mentioned peel strength can exhibit sufficient bonding strength even if the size is small, and therefore, it can be suitably used as an adhesive sheet for a test sheet where the area of the adhesive is easily limited. In a preferred aspect of the technology disclosed herein, the adhesive sheet is provided with a substrate, a first adhesive layer provided on one side of the substrate, and a second adhesive provided on the other side of the substrate. Double-sided adhesive sheet with substrate. By using an adhesive sheet having a base material, the workability of the adhesive sheet is improved, so that it is easier to manufacture a test piece having a higher shape accuracy. In a preferred aspect of the technology disclosed herein, the above-mentioned adhesive layer is an acrylic adhesive layer including an acrylic polymer as a base polymer. By using an acrylic adhesive as the adhesive, an adhesive sheet having adhesive properties suitable for the use of a test piece can be better realized. In a preferred aspect of the technology disclosed herein, the adhesive layer includes an adhesion-imparting resin in an amount of 20 to 60 parts by weight based on 100 parts by weight of the acrylic polymer. By formulating a specific amount of the adhesion-imparting resin in the acrylic pressure-sensitive adhesive, an adhesive sheet having characteristics suitable for the use of the test piece (such as adhesion or reagent retention) can be preferably realized. In a preferred aspect of the technology disclosed herein, the thickness of the adhesive sheet is 50 μm or less. Such a thin adhesive sheet can better function as a spacer between the substrate and the cover. In a preferred aspect of the technology disclosed herein, the test strip is a biosensor that is detachably connected to a biological sample measurement device. In the biosensors described above, the reagents used for sample measurement are relatively expensive. By using the adhesive sheet disclosed herein as an adhesive sheet for such a biosensor, the advantage of preventing loss of reagents can be effectively enjoyed. In addition, the analysis accuracy of sample measurement equipment such as biological sample measurement equipment represented by biosensors has been increasing year by year, and as a result, there has been a tendency to require higher quality test pieces. By using one of the preferred aspects of the adhesive sheet disclosed herein for this purpose, the strength of the test piece (typically, the bonding strength between members, etc.) can be increased, thereby creating a higher quality test Film (typically a biosensor). In addition, according to the present specification, a method for manufacturing a test piece for analyzing a sample can be provided. The manufacturing method includes the steps of preparing an adhesive sheet with a release liner, the adhesive sheet with a release liner having a double-sided adhesive sheet with an adhesive layer, and a first sheet covering a first adhesive surface of the adhesive sheet. A release liner and a second release liner covering the second adhesive surface of the adhesive sheet; a step of providing a hole penetrating at least the second release liner and the adhesive sheet in the adhesive sheet with the release liner; A step of peeling the first release liner from the adhesive sheet with a release liner, and bonding the first adhesive surface of the adhesive sheet to a test piece member A (for example, a substrate); and injecting a reagent into the second peeling The step of opening the above hole on the back of the pad. Further, typically, the manufacturing method may further include peeling the second release liner from the adhesive sheet with a release liner, and bonding the second adhesive surface of the adhesive sheet to the test piece member B (for example, coating Layer). In the above manufacturing method, the water contact angle of the back surface of the second release liner is preferably 70 ° or more. According to the above manufacturing method, loss of reagents can be prevented.

Hereinafter, preferred embodiments of the present invention will be described. In addition, the practitioner can understand the content necessary for the implementation of the present invention other than the matters specifically mentioned in the present specification based on the teachings about the implementation of the invention and the technical common sense at the time of application. The present invention can be implemented based on the contents disclosed in this specification and technical common sense in the field. In the drawings below, members and parts that perform the same function will be described with the same reference numerals, and overlapping descriptions may be omitted or simplified. In addition, the embodiments described in the drawings are modeled to clearly illustrate the present invention, and do not accurately indicate the size or reduction ratio of the adhesive sheet or test piece actually provided as a product. In this specification, "adhesive" refers to a material that has a state of being a soft solid (viscoelastic body) at a temperature region near room temperature, and is simply adhered to the adherend by pressure. . The adhesives referred to herein are as defined in "CA Dahlquist," Adhesion: Fundamental and Practice ", McLaren & Sons, (1966) P. 143", and generally have an elastic modulus E that satisfies the complex stretch. ^* (1 Hz) <10 ⁷ dyne / cm ² Materials (typically materials having the above properties at 25 ° C). <Configuration Example of Adhesive Sheet with Release Liner> The adhesive sheet with release liner disclosed herein has, for example, a cross-sectional structure as shown in FIG. 1. The adhesive sheet 1 with a release liner includes a double-sided adhesive sheet (double-sided adhesive sheet) 11. The double-sided adhesive sheet 11 includes a plastic film as a substrate 15 and a first adhesive layer 21 and a second adhesive layer 22 which are supported by both sides of the substrate 15, respectively. More specifically, a first adhesive layer 21 and a second adhesive layer 22 are provided on the first surface 15A and the second surface 15B (both of which are non-peelable) of the substrate 15, respectively. In addition, the adhesive sheet 1 with a release liner includes a first adhesive surface covering the double-sided adhesive sheet 11 (the adhesive surface of the first adhesive layer 21, a surface located on the side opposite to the substrate 15 side) 21A first peeling. The liner 31 and the second release liner 32 covering the second adhesive surface of the double-sided adhesive sheet 11 (the adhesive surface of the second adhesive layer 22 on the surface opposite to the substrate 15 side) 22A. In the double-sided adhesive sheet 11 before use (before attaching to an adherend), the first adhesive surface 21A of the first adhesive layer 21 is a surface (front surface) 31A on the side of the first adhesive surface 21A becoming a release surface. The first release liner 31 is protected. The second adhesive surface 22A of the second adhesive layer 22 is protected by a second release liner 32 in which a surface (front surface) 32A on the side of the second adhesive surface 22A is a release surface. The back surface (the surface opposite to the front surface 31A) 31B of the first release liner 31 constitutes the outer surface of the adhesive sheet 1 with the release liner. Moreover, the back surface (surface on the side opposite to the front surface 32A) 32B of the second release liner 32 also forms the outer surface of the adhesive sheet 1 with a release liner in the same manner as the back surface 31B of the first release liner 31. The technology disclosed here can be better applied to the double-sided adhesive sheet with a substrate shown in FIG. 1, and also can be applied to the double-sided adhesive without a substrate (that is, without a substrate) shown in FIG. 2. Sheet 12. As shown in FIG. 2, the double-sided adhesive sheet 12 before use is in the form of an adhesive sheet 2 with a release liner. It has an adhesive layer 20 without a substrate, and has a first adhesive surface (adhesive layer 20) covering it. The first peeling pad 31 of 20A and the second peeling surface covering it (the other sticking surface of the adhesive layer 20, the sticking surface located on the side opposite to the first sticking surface 20A), the second peeling of 20B垫 32。 The pad 32. The first adhesive surface 20A of the double-sided adhesive sheet 12 composed of the baseless adhesive layer 20 is protected by the first release liner 31 where the surface (front surface) 31A on the side of the first adhesive surface 20A becomes the release surface. The second adhesive surface 20B of the double-sided adhesive sheet 12 is protected by a second release liner 32 whose surface (front surface) 32A on the side of the second adhesive surface 20B is a release surface. <The first release liner and the second release liner> The technology disclosed here is characterized by any of the first release liner and the second release liner (hereinafter, collectively referred to as "release liner" in some cases). The water contact angle of the back surface (surface opposite to the side surface (front surface) of the adhesive layer) is 70 ° or more. Therefore, when a test piece is manufactured, even if a reagent is to be injected into a hole opened on the back surface of the first release liner or the second release liner, at least a part of the reagent is not injected into the hole. The injected reagent will not be wetted, diffused or absorbed, and will remain in the form of droplets on the back surface of the release liner. For example, by inclining the release liner or transferring the droplets using an inducing mechanism such as a dropper, and introducing the uninjected reagent (droplet) remaining on the back surface of the release liner into the well, the loss of the reagent can be prevented. Sometimes the operation of recovering the reagents that have not been injected in the injection operation and loading them into the required wells is called recovery injection and re-injection with new reagent droplets into the same wells. Inject to distinguish. In addition, the back surface of the release liner adjusted so that the water contact angle becomes 70 ° or more of water repellency as described above may be referred to as the back surface of the release liner whose water contact angle is less than 70 °. Water-based back). The above-mentioned water contact angle can be adjusted by selection of materials constituting the back surface of the release liner, surface treatment, and the like. The water contact angle of the back surface (water-repellent back surface) of the release liner was measured by the method described in the following examples. The water contact angle of one of the first release liner back surface and the second release liner back surface (water-repellent back surface) is preferably 90 ° or more (typically more than 90 °), more preferably 100 ° or more, and more preferably It is preferably 120 ° or more (for example, 130 ° or more). If the water contact angle is too large, liquid droplets may move too easily on the back surface of the first release liner and fall off from the back surface. Therefore, the water contact angle is preferably about 160 ° or less (for example, 150 ° or less). Furthermore, the water contact angle between the back surface of the first release liner and the other back surface of the second release liner may be less than 70 °, and may be 70 ° or more. The surface free energy of one of the first release liner back surface and the second release liner back surface (water-repellent back surface) disclosed herein is preferably less than 40 mJ / m ² . This makes it easy to prevent loss of reagents. The above surface free energy is preferably 30 mJ / m ² Below, more preferably 20 mJ / m ² Below (e.g. 15 mJ / m ² the following). From the viewpoint of reagent recoverability, the above surface free energy is more preferably 7 mJ / m ² Above (e.g. 10 mJ / m ² the above). In addition, the surface free energy of the back surface of the first release liner and the other back surface of the second release liner may not exceed 40 mJ / m. ² , Also 40 mJ / m ² the above. The surface free energy of the back surface (water-repellent back surface) of a release liner was calculated | required by the method as described in the following Example. As the release liner having a water-repellent back surface among the first release liner and the second release liner, a release liner having a front surface as a release surface and a back surface as a water-repellent surface is typically used. As a preferable example of such a release liner, the thing which performed the peeling process and the water repellent process on the release liner base material is mentioned. The release liner may be one that has been subjected to a release treatment on one surface of the release liner substrate and a water repellent treatment to the other surface. In a typical aspect, the release liner having a water-repellent back surface includes a release liner substrate (a release treatment object and a water repellency treatment object) as a support, and a release treatment layer provided on one surface of the substrate. And a water repellent treatment layer provided on the other surface of the substrate. The material of the release liner substrate disclosed herein is not particularly limited. For example, a single layer body (such as a plastic film) or a laminated body formed of plastic, paper, various fibers, or the like can be used. In addition, in this specification, a "plastic film" is typically a non-porous film, and is a concept different from a so-called non-woven fabric or woven fabric. Examples of the plastic film include polyolefins such as polyethylene (PE) and polypropylene (PP); polyethylene terephthalate (PET), polyethylene naphthalate (PEN), and poly (p-phenylene) Films of polyesters such as succinate (PBT); polyamides (so-called nylons); celluloses (so-called selefen). Plastic films can be non-stretchable or stretched (uniaxially stretched or biaxially stretched). As the paper substrate, for example, Japanese paper, foreign paper, dory paper, cellophane, kraft paper, stretch paper, crepe paper, clay coated paper, top coat paper, synthetic paper, and the like can be used. The basis weight of the paper substrate is not particularly limited, and it is generally suitable to use 50 to 100 g / m ² Left and right. Examples of the various fiber substrates include various fibrous substances (which may be any of natural fibers, semi-synthetic fibers, and synthetic fibers, such as cotton fibers, rayon staple fibers, manila hemp, pulp, cotton, acetate fibers, polyacrylic Ester fibers, polyvinyl alcohol fibers, polyamide fibers, polyolefin fibers, etc.) woven or non-woven fabrics obtained by singly or blending. Examples of the base material including other materials include: rubber sheet materials including natural rubber, butyl rubber, and the like; foaming of foams including foamed polyurethane, foamed polychloroprene rubber, and the like Body sheet materials; aluminum foil, copper foil and other metal foils; such composites. As a laminated body, the paper (for example, Dowling paper) laminated | stacked with the plastic film (for example, PE resin) on both sides is mentioned, for example. As a preferable release liner substrate mentioned above, a polyester film is mentioned, and a PET film is more preferable among them. Corresponding to the above release liner substrate, various surface modification treatments such as corona discharge treatment, plasma treatment, and primer coating may be performed on the surface on which the release treatment layer or water repellent treatment layer is provided. Various surface processing. In addition, if necessary, fillers (inorganic fillers, organic fillers, etc.), anti-aging agents, antioxidants, ultraviolet absorbers, antistatic agents, lubricants, plasticizers, colorants (pigments, dyes, etc.), etc. Various additives. The water-repellent back surface of the release liner disclosed herein can be formed using a water-repellent treatment agent such as a polysiloxane-based water-repellent treatment agent, a fluorine-based water-repellent treatment agent, or a long-chain alkyl-type water-repellent treatment agent. As such a water repellent treatment agent, those who can be used as a peeling treatment agent can select and use a water contact angle satisfying 70 ° or more based on technical common sense. Among them, a polysiloxane-based water repellent treatment agent is preferred. Alternatively, a water-repellent back surface can also be obtained by using the material of the self-releasing liner base material based on technical common sense and selecting a material whose water contact angle becomes 70 ° or more. For example, it is also possible to peel off olefin-based resins (for example, PE, PP, ethylene-propylene copolymer, PE / PP mixture), fluorine-based polymers (for example, polytetrafluoroethylene, polyvinylidene fluoride), and silicone rubber. The liner substrate is used as a release liner without subjecting the surface of the substrate to a water repellent treatment. In this case, the back surface of the release liner can be a water-repellent back surface without being subjected to a water-repellent treatment. As the polysiloxane-based water repellent treatment agent used in a preferred aspect, there is no particular limitation, and various polysiloxane-based materials that can achieve a water contact angle of 70 ° or more can be used. For example, heat-hardening properties (typically, heat-hardening properties) are given after application, and heat is applied by applying heat or free radiation (ultraviolet rays, alpha rays, beta rays, gamma rays, neutron rays, electron beams, etc.). Molding) polysiloxane based water repellent treatment agent, free radiation hardening (typically UV (ultraviolet, ultraviolet) hardening) polysiloxane based water repellent treatment agent, etc. These can be used individually by 1 type or in combination of 2 or more types. From the viewpoints of economical efficiency and simplicity of a device required for coating, a thermosetting (typically, thermosetting addition molding) polysiloxane-based water repellent treatment agent can be preferably used. The water repellent treatment agent may be any of a solvent-free type without a solvent, and a solvent type dissolved or dispersed in an organic solvent. In addition, it can also be used by mixing an appropriate amount of a solvent with a relatively low surface tension in a solvent-free water repellent treatment agent and adjusting the viscosity in a manner that is easy to impart (typically coating). Furthermore, a catalyst such as a platinum-based catalyst for improving reactivity can be added to the polysiloxane-based water repellent treatment agent such as the thermosetting property as described above. From the viewpoint of environmental sanitation or reduction of VOC (volatile organic compounds) when the water-repellent treatment layer is formed, it is preferable to use a solvent-free type that substantially contains no organic solvent and can be directly applied in this state. . The polysiloxane-based water repellent treatment agent as described above can be obtained from, for example, Yuesu Chemical Industry Co., Ltd. Examples of the method for forming the water-repellent treatment layer of the release liner disclosed herein include, for example, applying a water-repellent treatment agent such as a polysiloxane-based water-repellent treatment agent to the substrate of the release liner using various applicators, and drying it. Method for forming water repellent treatment layer. The coating machine can be appropriately selected from, for example, a direct gravure coater, an offset gravure coater, a roll coater, a bar coater, a die coater, and the like. There are no particular restrictions on the drying conditions, and drying conditions suitable for the water repellent treatment agent to be used can be appropriately selected. Usually, the drying temperature is about 80-150 ° C. In the case where the release liner disclosed herein has a water-repellent treatment layer, the thickness of the water-repellent treatment layer is not particularly limited. From the viewpoint of sufficiently obtaining water repellency, the thickness of the water repellent treatment layer is, for example, more preferably about 0.03 μm or more, and more preferably about 0.05 μm or more. From the viewpoints of film formability and cost, the thickness is, for example, about 5 μm or less (typically 3 μm or less). The application amount of the water-repellent treatment agent can be appropriately selected according to the type of the release liner substrate used, the type of the water-repellent treatment agent, and the like. For example, it is more suitable to be 0.01 g / m in terms of solid content. ² Above, preferably 0.05 g / m ² Above, more preferably 0.1 g / m ² Above, more preferably 0.5 g / m ² Above, more suitable is about 10 g / m ² Below, preferably 7 g / m ² Below, more preferably 5 g / m ² Below, more preferably 4 g / m ² the following. The release surface of the release liner disclosed herein can be formed by a conventional method using a known or conventional release treatment agent (for example, a release treatment agent such as a silicone-based, fluorine-based, or long-chain alkyl-based release treatment agent). For example, a PE resin surface of a forest paper laminated with a PE resin or a release surface obtained by subjecting a surface of a polyester release liner substrate to a release treatment using a polysiloxane-based release treatment agent can be preferably used. In addition, for example, an olefin-based resin (for example, PE, PP, an ethylene-propylene copolymer, and a PE / PP mixture), a fluoro-based polymer (for example, polytetrafluoroethylene, polyvinylidene fluoride), or silicone rubber can be formed. The release liner substrate is used as a release liner without performing a release treatment on the surface of the substrate. In this case, the surface (typically, the front surface) of the release liner can be a release surface without performing a release treatment. As a method for forming the release treatment layer of the release liner disclosed herein, a conventionally known method can be adopted. For example, the release liner substrate may be coated with a release treatment agent (for example, a silicone release treatment agent) as described above on the release liner substrate using various coaters, and dried to form a release treatment layer. As the above-mentioned coating machine, an example can be appropriately selected and exemplified as a coating machine which can be used in the formation of the water-repellent treatment layer. The drying conditions are not particularly limited, and the drying conditions suitable for the peeling treatment agent to be used can be appropriately selected. When the release liner disclosed herein has a release-treated layer, the thickness of the release-treated layer is not particularly limited. From the viewpoint of obtaining sufficient peelability, the thickness of the peeling treatment layer is, for example, preferably about 0.03 μm or more, and more preferably about 0.05 μm or more. From the viewpoints of film formability and cost, the thickness is, for example, about 5 μm or less (typically 3 μm or less). From the viewpoints of workability and the like, the thickness of the release liner disclosed herein is more preferably about 20 μm or more, preferably 30 μm or more (for example, 50 μm or more, and further 60 μm or more), and the thickness is more than The thickness is suitably about 200 μm or less, and preferably 160 μm or less (for example, 100 μm or less). The thickness of the first release liner and the second release liner may be the same or different. In a state where the release liner is peeled off in the order of the first release liner and the second release liner and an adhesive sheet is used, it is preferable that the thickness of the first release liner is thinner than that of the second release liner. Thereby, the peeling workability of the 1st release liner and the sticking workability of an adhesive sheet are improved. In addition, by providing the second release liner with a thickness to increase rigidity, it is easy to support the adhesive sheet with the second release liner after the first release liner is peeled off. <Adhesive layer> The adhesive layer disclosed here (in the case of a double-sided adhesive sheet with a base material, the first adhesive layer and the second adhesive layer are included, the same applies hereinafter) is known in the field of including an adhesive Acrylic polymers, rubber polymers, polyester polymers, urethane polymers, polyether polymers, polysiloxane polymers, polyamide polymers, fluorine polymers, etc. One or two or more kinds of various rubber-like polymers are used as the base polymer. The details will be described below. The adhesive layer disclosed herein is preferably an acrylic adhesive layer containing an acrylic polymer as a base polymer or a rubber adhesive layer containing a rubber polymer as a base polymer. . Alternatively, it may be an adhesive layer in which an acrylic polymer and a rubber polymer are used as a base polymer. (Acrylic Adhesive Layer) In a preferred aspect, the above-mentioned adhesive layer is in terms of characteristics (typically, adhesion or bending resistance, reagent retention, etc.), molecular design, and stability over time. Is an acrylic adhesive layer containing an acrylic polymer as a base polymer. In addition, in this specification, the "base polymer" of an adhesive means the main component of the polymer component contained in this adhesive (typically, it contains a component exceeding 50 weight%). (Acrylic polymer) As the acrylic polymer, for example, a monomer raw material containing an alkyl (meth) acrylate as a main monomer and further containing a sub-monomer having copolymerizability with the main monomer is preferable. Of polymers. Here, the main monomer refers to a component that accounts for more than 50% by weight of the total monomer components in the monomer raw material. As the alkyl (meth) acrylate, for example, a compound represented by the following formula (1) can be preferably used. CH ₂ = C (R ¹ COOR ² (1) Here, R in the above formula (1) ¹ Is a hydrogen atom or a methyl group. Again, R ² Is a chain alkyl group having 1 to 20 carbon atoms (hereinafter, the range of such carbon atoms may be expressed as "C _1-20 "). From the viewpoint of the storage modulus of the adhesive, R is preferred ² For C _1-14 (E.g. C _2-10 , Typically C _4-8 (Meth) acrylic acid alkyl ester of chain alkyl group, more preferably R ¹ Is a hydrogen atom and R ² For C _4-8 An alkyl acrylate of a chain alkyl group. Above R ² For C _1-20 The (meth) acrylic acid alkyl ester of a chain alkyl group may be used individually by 1 type, and may be used in combination of 2 or more type. Preferred alkyl (meth) acrylates include n-butyl acrylate (BA) and 2-ethylhexyl acrylate (2EHA). From the viewpoints of adhesion properties and processability, BA is more preferable. The blending ratio of the main monomer in the total monomer component is preferably 70% by weight or more (for example, 85% by weight or more, and typically 90% by weight or more). The upper limit of the blending ratio of the main monomer is not particularly limited, but is preferably set to 99.5% by weight or less (for example, 95% by weight or less). A secondary monomer having a copolymerizability with the alkyl (meth) acrylate which is a main monomer can play a role of introducing a crosslinking point to an acrylic polymer or improving the cohesive force of the acrylic polymer. As the secondary monomer, for example, a carboxyl group-containing monomer, a hydroxyl group-containing monomer, an acid anhydride group-containing monomer, a fluorene-containing amino group-containing monomer, an amine-containing monomer, a ketone-group-containing monomer, or a monomer having a nitrogen atom ring One or two or more kinds of functional group-containing monomers, such as a polymer, an alkoxy-containing silane-based monomer, a fluorene-imide-containing monomer, and an epoxy-containing monomer. For example, from the viewpoint of improving cohesion, an acrylic polymer obtained by copolymerizing a carboxyl group-containing monomer and / or a hydroxyl group-containing monomer as the above-mentioned secondary monomer is preferred. Preferred examples of the carboxyl group-containing monomer include acrylic acid (AA) and methacrylic acid (MAA). Examples of the hydroxyl-containing monomer include 2-hydroxyethyl (meth) acrylate, 2-hydroxypropyl (meth) acrylate, 3-hydroxypropyl (meth) acrylate, and 2-hydroxy (meth) acrylate Hydroxyalkyl (meth) acrylates such as butyl ester and 4-hydroxybutyl (meth) acrylate, unsaturated alcohols, and the like. Among them, hydroxyalkyl (meth) acrylate is preferred, and 2-hydroxyethyl acrylate (HEA) and 4-hydroxybutyl acrylate (4HBA) are more preferred. The amount of the above-mentioned secondary monomer is not particularly limited as long as it is appropriately selected so as to achieve the required cohesion. Generally, from the viewpoint of balance between adhesion and cohesion with good balance, the amount of the sub-monomer is more preferably 0.5% by weight or more, and more preferably 1% by weight or more of the total monomer component of the acrylic polymer. . The amount of the sub-monomer is more preferably 30% by weight or less, and preferably 10% by weight or less (for example, 5% by weight or less) of the total monomer components. When a carboxyl group-containing monomer is copolymerized in an acrylic polymer, the content of the carboxyl group-containing monomer is more preferably about 0.1% by weight or more in the total monomer component used in the synthesis of the acrylic polymer. It is preferably 0.5% by weight or more, more preferably 1% by weight or more, and more preferably about 15% by weight or less, more preferably 8% by weight or less, and even more preferably 5% by weight or less. When a hydroxyl-containing monomer is copolymerized in the acrylic polymer, the content of the hydroxyl-containing monomer is more preferably about 0.001% by weight or more in the total monomer component used in the synthesis of the acrylic polymer. It is preferably 0.01% by weight or more, more preferably 0.05% by weight or more, and more preferably about 10% by weight or less, more preferably 5% by weight or less, and even more preferably 2% by weight or less. Thereby, an adhesive with a higher level of adhesion and cohesion can be achieved. A monomer other than the above (other monomers) may be copolymerized in the acrylic polymer disclosed herein. The other monomers described above can be used, for example, for the purpose of adjusting the glass transition temperature of an acrylic polymer and adjusting the adhesive properties (for example, peelability). For example, as a monomer which can improve the cohesiveness of an adhesive agent, a sulfonic acid group containing monomer, a phosphate group containing monomer, a cyano group containing monomer, a vinyl ester, an aromatic vinyl compound, etc. are mentioned. These other monomers may be used alone or in combination of two or more. Among them, vinyl esters are mentioned as preferable examples. Specific examples of the vinyl esters include vinyl acetate (VAc), vinyl propionate, vinyl laurate, and the like. Among these, Vac is preferred. The content of the other monomers is more preferably about 30% by weight or less, more preferably 10% by weight or less, and more preferably about 10% by weight of the total monomer components used in the synthesis of the acrylic polymer. 0.01% by weight or more (for example, 0.1% by weight or more). The copolymerization composition of the acryl-based polymer is suitably designed such that the glass transition temperature (Tg) of the polymer becomes -15 ° C or lower (typically -70 ° C or higher and -15 ° C or lower), and preferably- 25 ° C or lower (for example, -60 ° C or higher and -25 ° C or lower), more preferably -40 ° C or lower (for example, -60 ° C or higher and -40 ° C or lower). From the viewpoints of adhesion and the like, it is preferable to set the Tg of the acrylic polymer to the above-mentioned upper limit value or less. The Tg of the acrylic polymer can be adjusted by appropriately changing the monomer composition (that is, the type or amount ratio of the monomers used in the synthesis of the polymer). Here, the Tg of the acrylic polymer refers to the weight fraction (copolymerization ratio based on weight) based on the Tg of the homopolymer of each monomer constituting the polymer and the weight of the monomer, and according to Fox ( Fox). The formula of Fox is as follows, which is the relationship between the Tg of the copolymer and the glass transition temperature Tgi of the homopolymer obtained by homopolymerizing each of the monomers constituting the copolymer. 1 / Tg = Σ (Wi / Tgi) In the above formula of Fox, Tg represents the glass transition temperature (unit: K) of the copolymer, and Wi represents the weight fraction (weight) of the monomer i in the copolymer. The basic copolymerization ratio), Tgi represents the glass transition temperature (unit: K) of the homopolymer of monomer i. As the Tg of the homopolymer, a value described in known data is also used. In the technique disclosed here, as the Tg of the homopolymer, specifically, the following values are used. 2-ethylhexyl acrylate-70 ℃ butyl acrylate-55 ℃ vinyl acetate 32 ℃ acrylic acid 106 ℃ methacrylic acid 228 ℃ 2-hydroxyethyl acrylate -15 ℃ 4-hydroxybutyl acrylate -40 ℃ For the Tg of the homopolymer other than those exemplified, the values described in "Polymer Handbook" (3rd Edition, John Wiley & Sons, Inc., 1989) were used. When it is not described in the above-mentioned Polymer Handbook, the value obtained by the measurement method described in Japanese Patent Laid-Open No. 2007-51271 is used. The method for obtaining an acrylic polymer is not particularly limited, and various polymerization methods known as a method for synthesizing an acrylic polymer, such as a solution polymerization method, an emulsion polymerization method, a block polymerization method, and a suspension polymerization method, can be appropriately used. For example, a solution polymerization method can be preferably used. As a method for supplying a monomer when performing solution polymerization, a one-time addition method for supplying all monomer raw materials at a time, a continuous supply (dropwise addition) method, a batchwise supply (dropwise addition) method, and the like can be suitably adopted. The polymerization temperature can be appropriately selected according to the type of the monomers and solvents used, the type of the polymerization initiator, and the like, and can be set to, for example, about 20 ° C to 170 ° C (typically 40 ° C to 140 ° C). Alternatively, photopolymerization (typically, in the presence of a photopolymerization initiator) by irradiation of light such as UV or active energy ray irradiation polymerization such as radiation polymerization by irradiation of beta rays or gamma rays may be used. . The solvent (polymerization solvent) used in the solution polymerization can be appropriately selected from previously known organic solvents. For example, aromatic compounds such as toluene (typically aromatic hydrocarbons); or acetates such as ethyl acetate and butyl acetate; hexane, cyclohexane, and methylcyclohexane can be preferably used. And other aliphatic or alicyclic hydrocarbons. The initiator used in the polymerization can be appropriately selected from previously known polymerization initiators according to the type of the polymerization method. For example, one or two or more azo-based polymerization initiators such as 2,2'-azobisisobutyronitrile (AIBN) can be preferably used. As another example of the polymerization initiator, persulfates such as potassium persulfate; peroxide-based initiators such as benzamidine peroxide and hydrogen peroxide; substituted ethane-based initiators such as phenyl substituted ethane Agents; aromatic carbonyl compounds, etc. As still another example of the polymerization initiator, a redox-based initiator based on a combination of a peroxide and a reducing agent is mentioned. Such a polymerization initiator may be used individually by 1 type, or may be used in combination of 2 or more type. The amount of the polymerization initiator used may be a normal amount, and for example, it can be selected from a range of about 0.005 to 1 part by weight (typically 0.01 to 1 part by weight) with respect to 100 parts by weight of the total monomer component. The weight average molecular weight (Mw) of the base polymer (preferably an acrylic polymer) disclosed herein is not particularly limited. From the viewpoint of balancing cohesion and adhesion at a high level, the Mw of the base polymer (preferably an acrylic polymer) is preferably 10 × 10 ⁴ Above, more preferably 20 × 10 ⁴ Above, more preferably 35 × 10 ⁴ the above. The Mw is preferably 500 × 10. ⁴ Below, more preferably 110 × 10 ⁴ Following (e.g. 75 × 10 ⁴ Below), more preferably 90 × 10 ⁴ Following (e.g. 65 × 10 ⁴ the following). Here, Mw refers to a standard polystyrene conversion value obtained by gel permeation chromatography (GPC). As the GPC device, for example, the model name "HLC-8320GPC" (column: TSKgel GMH-H (S), manufactured by Tosoh Corporation) may be used. The same applies to the following examples. (Rubber-based polymer) In another preferred aspect, the adhesive layer is composed of a rubber-based adhesive. Here, the rubber-based adhesive refers to an adhesive containing a rubber-based polymer as a base polymer. Examples of the rubber-based polymer include natural rubber, styrene butadiene rubber (SBR), acrylonitrile butadiene rubber (NBR), isoprene rubber, chloroprene rubber, polyisobutylene, butyl rubber, Recycled rubber, etc. These can be used individually by 1 type or in combination of 2 or more types. A preferred aspect of the rubber-based adhesive contains a block copolymer of a monovinyl-substituted aromatic compound and a conjugated diene compound as a base polymer. The aforementioned monovinyl-substituted aromatic compound refers to a compound having a functional group having a vinyl group bonded to an aromatic ring. As a representative example of the aromatic ring, a benzene ring (a benzene ring substituted with a functional group (for example, an alkyl group) having no vinyl group) may be mentioned. Specific examples of the monovinyl-substituted aromatic compound include styrene, α-methylstyrene, vinyl toluene, and vinyl xylene. Specific examples of the conjugated diene compound include 1,3-butadiene, isoprene, and the like. Such a block copolymer may be used individually by 1 type, and may use 2 or more types together for a base polymer. The A segment (hard segment) in the block copolymer is preferably 70% by weight or more (more preferably 90% by weight or more) of the copolymerization ratio of the monovinyl-substituted aromatic compound (can be used in combination of two or more types). , Can also be substantially 100% by weight). The B segment (soft segment) in the block copolymer is preferably a copolymerization ratio of the conjugated diene compound (two or more types can be used in combination) of 70% by weight or more (more preferably 90% by weight or more). It may be substantially 100% by weight). According to this block copolymer, a higher-performance adhesive sheet can be realized. The block copolymer may be in the form of a diblock body, a triblock body, a radial body, a mixture of these, and the like. In the triblock body and the radial body, an A segment (for example, a styrene block) is preferably arranged at the end of the polymer chain. The reason for this is that the A segments arranged at the ends of the polymer chains easily aggregate to form domains, thereby forming an approximate cross-linked structure and improving the cohesiveness of the adhesive. As the block copolymer in the technology disclosed herein, from the viewpoint of adhesion (peel strength) or bending resistance to an adherend, for example, a diblock ratio of 30% by weight or more can be preferably used. (More preferably 40% by weight or more, still more preferably 50% by weight or more, even more preferably 60% by weight or more, typically 65% by weight or more, such as 70% by weight or more). From the standpoint of resistance to stress that is continuously applied, a diblock ratio of 90% by weight or less (more preferably 85% by weight or less, such as 80% by weight or less) can be preferably used. For example, a block copolymer having a diblock ratio of 60 to 85% by weight is preferably used. (Styrenic block copolymer) In a preferred aspect of the technology disclosed herein, the base polymer-based styrene-based block copolymer described above. For example, the above-mentioned base polymer can be preferably implemented in a state in which at least one of a styrene isoprene block copolymer and a styrene butadiene block copolymer is included. In the styrene-based block copolymer included in the adhesive, the ratio of the styrene isoprene block copolymer is preferably 70% by weight or more, or the ratio of the styrene butadiene block copolymer is 70% by weight. % Or more, or the total ratio of the styrene isoprene block copolymer and the styrene butadiene block copolymer is 70% by weight or more. In a preferred aspect, substantially all (for example, 95 to 100% by weight) of the styrene-based block copolymer is a styrene-isoprene block copolymer. In another preferred aspect, substantially all (for example, 95 to 100% by weight) of the styrene-based block copolymer is a styrene-butadiene block copolymer. According to this composition, the effect of applying the technology disclosed herein can be better exerted. The styrenic block copolymer may be in the form of a diblock body, a triblock body, a radial body, a mixture of these, and the like. In the triblock body and the radial body, a styrene block is preferably arranged at the end of the polymer chain. The reason is that the styrene blocks arranged at the end of the polymer chain easily aggregate to form a styrene domain, thereby forming an approximate cross-linked structure and improving the cohesiveness of the adhesive. As the styrenic block copolymer used in the technology disclosed herein, in terms of adhesion (peel strength) or bending resistance to an adherend, for example, a diblock ratio can be preferably used. 30% by weight or more (more preferably 40% by weight or more, still more preferably 50% by weight or more, particularly preferably 60% by weight or more, and typically 65% by weight or more). It may be a styrene-based block copolymer having a diblock ratio of 70% by weight or more (for example, 75% by weight or more). From the viewpoint of holding power and the like, a styrene-based block copolymer having a diblock ratio of 90% by weight or less (more preferably 85% by weight or less, such as 80% by weight or less) can be preferably used. For example, a styrene-based block copolymer having a diblock ratio of 60 to 85% by weight can be preferably used. The styrene content of the styrene-based block copolymer may be, for example, 5 to 40% by weight. From the viewpoints of bending resistance and retention, a styrene-based block copolymer having a styrene content of 10% by weight or more (more preferably, 10% by weight or more, for example, 12% by weight or more) is generally preferred. From the viewpoint of adhesion to the adherend, the styrene content is preferably 35% by weight or less (typically 30% by weight or less, more preferably 25% by weight or less, such as less than 20% by weight). ). For example, a styrene-based block copolymer having a styrene content of 12% by weight or more and less than 20% by weight can be preferably used. (Adhesion imparting agent) The adhesive layer disclosed herein may be a composition containing an adhesion imparting agent. The adhesion-imparting agent is not particularly limited. For example, rosin-based adhesion-imparting resins, terpene-based adhesion-imparting resins, hydrocarbon-based adhesion-imparting resins, epoxy-based adhesion-imparting resins, polyamide-based adhesion-imparting resins, and elastic system adhesion can be used. Various adhesion-imparting resins such as resin-imparting agents, phenol-based adhesion-imparting resins, and ketone-based adhesion-imparting resins. Such an adhesion-imparting resin may be used singly or in combination of two or more kinds. Specific examples of the rosin-based adhesion-imparting resin include unmodified rosin (raw rosin) such as rosin gum, wood rosin, tall oil rosin, and the like, which are modified by hydrogenation, disproportionation, and polymerization. Modified rosin (hydrogenated rosin, disproportionated rosin, polymerized rosin, other chemically modified rosin, etc., the same below); other various rosin derivatives. Examples of the above-mentioned rosin derivatives include those obtained by esterifying unmodified rosin with alcohols (that is, esters of rosin), and those obtained by esterifying modified rosin with alcohols (that is, modified Rosin esters) and other rosin esters; Unsaturated fatty acids modified with unsaturated fatty acids or modified rosin modified unsaturated rosins; Unsaturated fatty acids modified rosin esters modified Saturated fatty acid modified rosin esters; Rosin alcohols obtained by reducing the carboxyl group of unmodified rosin, modified rosin, unsaturated fatty acid modified rosin or unsaturated fatty acid modified rosin ester; unmodified Metal salts of rosin (especially rosin esters) such as rosin, modified rosin, various rosin derivatives; phenol and rosin (unmodified rosin, modified rosin, various rosin derivatives, etc.) by using an acid catalyst ) Rosin phenol resin and the like obtained by addition and thermal polymerization. When an acrylic polymer is used as a base polymer, it is preferable to use a rosin-based adhesion-imparting resin. From the viewpoint of improving adhesion properties such as adhesion, it is more preferable to use two or three or more different types and characteristics (for example, softening point) in combination with the rosin-based adhesion-imparting resin. Examples of terpene-based adhesion-imparting resins include terpene resins such as α-pinene polymers, β-pinene polymers, and dipentene polymers; and modification of these terpene resins (phenol modification, Aromatic modification, hydrogenation modification, hydrocarbon modification, etc.). Examples of the modified terpene resin include a terpene-modified phenol resin, a styrene-modified terpene resin, an aromatic-modified terpene resin, and a hydrogenated terpene resin. When an acrylic polymer is used as a base polymer, a terpene-based adhesion-imparting resin (for example, a terpene-modified phenol resin) is preferably used. In particular, from the viewpoint of improving adhesion properties such as adhesion, it is preferred to use one of the above-mentioned terpene-based adhesion-imparting resin (for example, a terpene-modified phenol resin) in combination with a different type or characteristic (for example, softening point) or 2 or more. Examples of the hydrocarbon-based adhesion-imparting resin include aliphatic hydrocarbon resins, aromatic hydrocarbon resins, aliphatic cyclic hydrocarbon resins, aliphatic-aromatic petroleum resins (styrene-olefin copolymers, etc.), Various hydrocarbon resins, such as aliphatic-alicyclic petroleum resin, hydrogenated hydrocarbon resin, lavender resin, lavender-indene resin. In the technology disclosed herein, as the adhesion-imparting resin, a softening point (softening temperature) of about 70 ° C. or higher (preferably about 100 ° C. or higher, more preferably about 110 ° C. or higher) can be preferably used. According to the pressure-sensitive adhesive having an adhesion-imparting resin having a softening point having a softening point above the above-mentioned lower limit value, a pressure-sensitive adhesive sheet having better adhesion can be realized. Among the above-exemplified adhesion-imparting resins, the terpene-based adhesion-imparting resin (for example, a terpene-modified phenol resin) having a softening point and the rosin-based adhesion-imparting resin (for example, an esterified product of polymerized rosin) can be preferably used. The upper limit of the softening point of the adhesion-imparting resin is not particularly limited, and may be, for example, about 200 ° C or lower (typically about 180 ° C or lower). The softening point of the adhesion-imparting resin referred to herein is defined as a value measured by a softening point test method (ring and ball method) specified by any one of JIS K 5902 and JIS K 2207. The use amount of the adhesion-imparting agent is not particularly limited, and can be appropriately set according to the target performance (adhesion, reagent retention, etc.). For example, it is more suitable to set the adhesion-imparting agent to about 10 parts by weight or more, more preferably 20 parts by weight or more, based on 100 parts by weight of the base polymer (for example, acrylic polymer) based on the solid content. It is 30 parts by weight or more, more preferably about 100 parts by weight or less, preferably 80 parts by weight or less, more preferably 60 parts by weight or less, and even more preferably 50 parts by weight or less. (Acrylic Oligomer) The adhesive composition disclosed herein may also include an acrylic oligomer. By using an acrylic oligomer, adhesion and bending resistance can be improved in a good balance. In addition, in the case where the adhesive composition is hardened by active energy ray irradiation (for example, UV irradiation), the acrylic oligomer is less likely to be generated than an adhesion-imparting resin such as a rosin-based or terpene-based resin. Advantages of hardening hindrances, such as hindering polymerization of unreacted monomers. In addition, an acrylic oligomer is a polymer which contains an acrylic monomer as a constituent monomer component, and is defined as a polymer whose Mw is smaller than the said acrylic polymer. The Mw of the acrylic oligomer is not particularly limited, but is typically 0.1 × 10 ⁴ ～ 3 × 10 ⁴ about. From the viewpoint of improving the adhesion properties (such as adhesion or bending resistance), the Mw of the acrylic oligomer is preferably 1.5 × 10. ⁴ Below, more preferably 1 × 10 ⁴ Hereinafter, it is more preferably 0.8 × 10 ⁴ Following (e.g. 0.6 × 10 ⁴ the following). From the viewpoint of the cohesiveness of the adhesive, the Mw is preferably 0.2 × 10. ⁴ Above (e.g. 0.3 × 10 ⁴ the above). The molecular weight of the acrylic oligomer can be adjusted during polymerization using a chain transfer agent or the like as necessary. When the adhesive composition disclosed here contains an acrylic oligomer, the content of the acrylic oligomer is more preferably 100 parts by weight relative to 100 parts by weight of the base polymer (typically, an acrylic polymer). 0.5 parts by weight or more. From the viewpoint of making the effect of the acrylic oligomer better, the content of the acrylic oligomer is preferably 1 part by weight or more (for example, 5 parts by weight or more, typically 10 parts by weight or more). ). From the viewpoints of hardenability of the adhesive composition and compatibility with a base polymer (typically an acrylic polymer), the content of the acrylic oligomer is more preferably set to less than 50 weight. Parts (for example, up to 30 parts by weight), preferably up to 20 parts by weight (for example, up to 15 parts by weight). (Crosslinking agent) The adhesive composition for forming an adhesive layer preferably contains a crosslinking agent. The type of the cross-linking agent is not particularly limited, and it can be appropriately selected and used from previously known cross-linking agents. Examples of such a crosslinking agent include an isocyanate-based crosslinking agent, an epoxy-based crosslinking agent, an oxazoline-based crosslinking agent, an aziridine-based crosslinking agent, a melamine-based crosslinking agent, and a carbodiimide. Based crosslinking agents, amine based crosslinking agents, peroxide based crosslinking agents, metal chelate based crosslinking agents, metal alkoxide based crosslinking agents, metal salt based crosslinking agents, and the like. The crosslinking agent may be used singly or in combination of two or more kinds. From the viewpoint of preventing paste overflow or bending resistance, an isocyanate-based crosslinking agent, an epoxy-based crosslinking agent, or a melamine-based crosslinking agent is preferred, and an isocyanate-based crosslinking agent or an epoxy-based crosslinking agent is more preferred. It is particularly preferable to use an isocyanate-based crosslinking agent and an epoxy-based crosslinking agent together. Examples of the isocyanate-based crosslinking agent include aromatic isocyanates such as toluene diisocyanate and xylene diisocyanate; alicyclic isocyanates such as isophorone diisocyanate; and aliphatic isocyanates such as hexamethylene diisocyanate. More specifically, trimethylolpropane / toluene diisocyanate terpolymer adduct (trade name "Coronate L", manufactured by Tosoh Corporation), trimethylolpropane / hexamethylene diisocyanate terpolymer can be exemplified. Isocyanate adducts such as adducts (trade name "Coronate HL", manufactured by Tosoh Corporation), isocyanurate bodies of hexamethylene diisocyanate (trade name "Coronate HX", manufactured by Tosoh Corporation), and the like. These can be used individually by 1 type or in combination of 2 or more types. Examples of the epoxy-based crosslinking agent include N, N, N ', N'-tetraglycidyl-m-xylylenediamine (trade name "TETRAD-X", manufactured by Mitsubishi Gas Chemical Co., Ltd.), 1, 3 -Bis (N, N-diglycidylaminomethyl) cyclohexane (trade name "TETRAD-C", manufactured by Mitsubishi Gas Chemical Co., Ltd.) and the like. Examples of the melamine-based crosslinking agent include hexamethylolmelamine, butylated melamine resin (trade name "SUPER BECKAMINE J-820-60N", manufactured by DIC Corporation), and the like. The amount of the cross-linking agent contained in the above-mentioned adhesive composition is not particularly limited. From the viewpoint of considering both the adhesive force and the cohesive force, it is generally more suitable to be 100 relative to the base polymer (typically an acrylic polymer). The weight part is about 0.01 weight part or more, Preferably it is 0.02 weight part or more (for example, 0.1 weight part or more). In addition, it is usually more preferably about 10 parts by weight or less, and preferably 5 parts by weight or less (for example, 3 parts by weight or less) based on 100 parts by weight of the base polymer (typically an acrylic polymer). When the above-mentioned adhesive composition contains an isocyanate-based crosslinking agent as a crosslinking agent, the content of the isocyanate-based crosslinking agent is more preferably set to 100 parts by weight based on 100 parts by weight of the base polymer (typically, an acrylic polymer). 0.1 parts by weight or more, preferably 0.3 parts by weight or more, and more preferably 0.5 parts by weight or more. The content of the isocyanate-based crosslinking agent is more preferably about 10 parts by weight or less, preferably 5 parts by weight or less, and more preferably 3 parts by weight or less. When the above-mentioned adhesive composition contains an epoxy-based crosslinking agent as a crosslinking agent, the content of the epoxy-based crosslinking agent is more preferably 100 parts by weight based on 100 parts by weight of the base polymer (typically, an acrylic polymer). It is 0.0001 weight part or more, Preferably it is 0.001 weight part or more, More preferably, it is 0.01 weight part or more. The content of the epoxy-based crosslinking agent is more preferably about 1 part by weight or less, preferably 0.5 part by weight or less, and more preferably 0.1 part by weight or less. (Other Additives) The above-mentioned adhesive composition may contain a leveling agent, a cross-linking aid, a plasticizer, a softener, a filler, a colorant (dye, pigment), an antistatic agent, an anti-aging agent, and an ultraviolet absorbing agent as necessary Various additives commonly used in the field of adhesive composition such as agents, antioxidants, and light stabilizers. About such various additives, a conventionally known one can be used by a conventional method, and since it is not a person who gives a characteristic to this invention in particular, detailed description is abbreviate | omitted. (Method for Forming Adhesive Layer) The adhesive layer disclosed herein can be formed by a conventionally known method. For example, a method of forming an adhesive layer by applying an adhesive composition to a peelable surface (release surface) and drying it can be employed. Alternatively, a method (direct method) of forming an adhesive layer by directly applying (typically applying) an adhesive composition to a film-like substrate and drying it can be employed. In addition, it is also possible to form an adhesive layer on the surface by applying an adhesive composition to a peelable surface (release surface) and drying it, and transfer the adhesive layer to a film-like substrate. Method (transfer method). As the release surface, a surface of a release liner can be used. In addition, the adhesive layer disclosed herein is typically formed continuously, but is not limited to this form. For example, the adhesive layer may be an adhesive layer formed in a regular or random pattern such as dots or stripes. The form of the adhesive composition disclosed herein is not particularly limited. For example, the form (solvent type) of the form (solvent type) of the organic solvent containing the adhesive (adhesive component) having the composition described above may be dispersed in Adhesive composition in the form of an aqueous solvent (water-dispersible type, typically an aqueous latex type), hot-melt type adhesive composition, active energy ray-curable type adhesive composition, and the like. From the viewpoint of easily achieving better adhesion, reagent retention, and bending resistance, a solvent-based or water-dispersible adhesive composition can be preferably used. From the viewpoint of achieving higher adhesive properties, a solvent-based adhesive composition is particularly preferred. Typically, the solvent-based adhesive composition is prepared in the form of a solution containing the above components in an organic solvent. The organic solvent can be appropriately selected from known or commonly used organic solvents. For example, aromatic compounds such as toluene and xylene (typically aromatic hydrocarbons) can be used; acetates such as ethyl acetate and butyl acetate; hexane, cyclohexane, methylcyclohexane, etc. Aliphatic or alicyclic hydrocarbons; halogenated alkanes such as 1,2-dichloroethane; ketones such as methyl ethyl ketone and acetone; or two or more mixed solvents. Although not particularly limited, it is generally more suitable to prepare the solvent-based adhesive composition as a solid content (NV) of 20 to 65% by weight (for example, 25 to 55% by weight). If the NV is too low, the manufacturing cost tends to increase, and if the NV is too high, the operability such as coatability may decrease. The application of the adhesive composition can be performed using, for example, a conventionally known coater such as a gravure roll coater, a die coater, and a bar coater. Alternatively, the adhesive composition may be applied by an impregnation method or a curtain coating method. From the viewpoint of promoting a crosslinking reaction and improving manufacturing efficiency, the drying of the adhesive composition is preferably performed under heating. The drying temperature can be, for example, about 40 to 150 ° C (preferably about 60 to 130 ° C). After the adhesive composition is dried, curing can also be carried out for the purpose of adjusting the movement of components in the adhesive layer, proceeding the cross-linking reaction, and mitigating the deformation that may exist in the substrate or the adhesive layer. In a preferred aspect, the gel fraction of the adhesive layer is 23% or more, and more preferably 25% or more. The adhesive sheet having the above-mentioned gel fraction having a specific value or more has no paste overflow after processing such as punching, and therefore has excellent processability. It does not damage the appearance of the cut test piece. In addition, there is no overflow of the paste, which can be an advantageous feature in an adhesive sheet for a test piece which is subjected to processing such as formation of holes or capillaries. From the viewpoint of reagent retention, the above-mentioned gel fraction is more preferably about 65% or less, preferably 55% or less, more preferably 45% or less, and still more preferably 35% or less (for example, 30% or less). By making the gel fraction of the adhesive layer below a certain value, it is possible to better prevent the reagent contained in the double-sided adhesive sheet from leaking from the adhesive surface of the adhesive sheet. Furthermore, by using an adhesive layer having a gel fraction in the above range, the bending resistance is also improved. The gel fraction of the adhesive layer was measured by the method described in the following examples. The thickness of the adhesive layer disclosed herein is not particularly limited, and may be appropriately selected according to the purpose. Generally, from the standpoint of adhesive properties, the thickness of the adhesive layer is more preferably about 1 μm or more, preferably 3 μm or more, more preferably 5 μm or more, and still more preferably 10 μm or more. From the viewpoints of productivity such as drying efficiency and test piece size, the thickness of the adhesive layer is more preferably about 200 μm or less, preferably 100 μm or less, more preferably 50 μm or less, and further preferably 30 μm. Or less (for example, 20 μm or less). In the case of a double-sided adhesive sheet having an adhesive layer on both sides of the substrate, the thickness of each adhesive layer may be the same or different. <Substrate> When the technology disclosed here is applied to a double-sided adhesive sheet with a substrate, as the substrate, for example, a polyolefin film such as a PE film, a PP film, and an ethylene-propylene copolymer film can be appropriately selected and used. Polyester films such as series films, PET films, and plastic films such as polyvinyl chloride films; foams containing foams such as polyurethane foam, PE foam, and polychloroprene foam Sheets; woven and non-woven fabrics obtained from various fibrous materials (natural fibers such as hemp and cotton, synthetic fibers such as polyester, vinylon, and semi-synthetic fibers such as acetate, etc.) The concept of paper such as Japanese paper and dory paper); metal foils such as aluminum foil and copper foil. A hydrophilic polymer film containing carboxymethyl cellulose (CMC) or the like can also be used as a substrate. As the plastic film, any of a non-stretched film and a stretched (uniaxially stretched or biaxially stretched) film can be used. Among these, a plastic film is preferred from the viewpoints of dimensional stability, thickness accuracy, economy (cost), workability such as punching, and tensile strength. Among plastic films, polyester films are particularly preferred. The surface of the substrate may also be subjected to surface treatment such as coating of a primer, corona discharge treatment and the like. In a preferred aspect, the substrate may be colored white. The use of a white substrate makes it easy to confirm the presence or absence of attachments such as stains, is excellent in cleanliness, and is also good in terms of hygiene. The adhesive sheet provided with a white substrate can be preferably used as a test piece for medical purposes. In addition, the white substrate has the advantage of easily recognizing the sample taken on the test piece. When the sample is a blood sample, the visibility of the sample is particularly excellent. The degree of whiteness (whiteness) is calculated as L * (lightness) specified by the L * a * b * color system, preferably 87 or more (for example, 87 to 100), and more preferably 90 or more (for example, 90 to 100) . The a * or b * specified by the L * a * b * color system can be appropriately selected according to the value of L *. For example, a * or b * is preferably in a range of -10 to 10 (more preferably -5 to 5 and even more preferably -2.5 to 2.5). Furthermore, in this specification, L *, a *, and b * specified by the L * a * b * colorimetric system are obtained by using a color difference meter (for example, a color difference meter manufactured by Minolta, trade name " CR-200 "). Furthermore, the L * a * b * color system is a color space recommended by the International Commission on Illumination (CIE) in 1976 and referred to as the CIE1976 (L * a * b *) color system. The L * a * b * color measurement system is regulated by JIS Z 8729 in the Japanese Industrial Standards. Examples of the white colorant used when the substrate is colored white include titanium oxide (titanium dioxide such as rutile titanium dioxide and anatase titanium dioxide), zinc oxide, aluminum oxide, silicon oxide, zirconia, and magnesium oxide. , Calcium oxide, tin oxide, barium oxide, cesium oxide, yttrium oxide, magnesium carbonate, calcium carbonate (light calcium carbonate, heavy calcium carbonate, etc.), barium carbonate, zinc carbonate, aluminum hydroxide, calcium hydroxide, hydroxide Magnesium, zinc hydroxide, aluminum silicate, magnesium silicate, calcium silicate, barium sulfate, calcium sulfate, barium stearate, zinc white, zinc sulfide, talc, clay, kaolin, titanium phosphate, mica, gypsum, white carbon , Inorganic white colorants such as diatomite, bentonite, zinc barium white, zeolite, sericite, kaolin, or acrylic resin particles, polystyrene resin particles, polyurethane resin particles, Organic white colorants such as amine resin particles, polycarbonate resin particles, polysiloxane resin particles, urea-formalin resin particles, and melamine resin particles. The amount of the white colorant used is not particularly limited, and it may be an amount that is appropriately adjusted so as to impart desired optical characteristics (typically whiteness). The thickness of the substrate can be appropriately selected according to the purpose. Generally, it is more preferably approximately 1 μm or more. From the viewpoint of strength or processability, it is preferably 2 μm or more, and more preferably 3 μm or more. The thickness of the substrate is usually preferably 500 μm or less (typically 200 μm or less). When the substrate-attached adhesive sheet disclosed here is used for a portable small-sized test piece, the thickness of the substrate is preferably 100 μm or less, more preferably 50 μm or less, and further preferably 30 μm. Or less (for example, 20 μm or less). In a preferred aspect, the thickness of the substrate in the double-sided adhesive sheet with substrate is 15 μm or less (for example, 10 μm or less, typically 7 μm or less). An adhesive sheet having such a thin substrate can be particularly preferably used for a thinner test piece. <Total thickness of double-sided adhesive sheet> The total thickness of the double-sided adhesive sheet (thickness of the double-sided adhesive sheet excluding the release liner) in the technology disclosed herein is not particularly limited. For example, a double-sided adhesive sheet having a thickness of about 10 μm or more can be used. From the viewpoint of exhibiting good adhesive properties (adhesive strength, etc.), the thickness of the double-sided adhesive sheet is preferably 15 μm or more (typically 25 μm or more). The thickness of the double-sided adhesive sheet is usually about 300 μm or less (for example, 200 μm or less). When the double-sided adhesive sheet disclosed here is used for a portable small-sized test piece, the total thickness of the double-sided adhesive sheet is preferably 100 μm or less, more preferably 70 μm or less, and further preferably 50 μm or less (for example, 40 μm or less). The double-sided adhesive sheet having the above-mentioned total thickness is, for example, particularly suitable as a double-sided adhesive sheet that functions as a spacer that specifies a sampling amount of a sample to a test piece. It can be a good response to the decrease in sample size accompanied by the increase in analysis accuracy. <Characteristics of the double-sided adhesive sheet with release liner> The double-sided adhesive sheet disclosed herein is preferably the first adhesive surface and / or the second adhesive surface (preferably the first adhesive surface and the second adhesive surface) of the double-sided adhesive sheet. Both of the second adhesive surfaces) show 180-degree peel strength (also referred to as "adhesive force") of 4 N / 20 mm or more. The double-sided adhesive sheet having the above-mentioned adhesive force can exhibit good bonding strength as an adhesive sheet for a test piece having a small bonding area. The above adhesive force is more preferably 6 N / 20 mm or more, further preferably 7 N / 20 mm or more, and even more preferably 8 N / 20 mm or more (for example, 8.5 N / 20 mm or more). The 180-degree peel strength refers to the use of a stainless steel plate as the adherend, and a 2 kg roller is reciprocated once to press the adhesive surface of the adhesive sheet to the adherend surface. After being left for 30 minutes, the peeling angle is in accordance with JIS Z 0237. Measured at 180 ° and 300 mm / min. More specifically, it measured by the method as described in the following example. In a preferred aspect, the peeling force (peel strength of the first release liner) of the first adhesive surface of the double-sided adhesive sheet may not exceed 1 N / 50 mm (for example, 0.5 N / 50 mm or less, (Typically 0.4 N / 50 mm or less). Similarly, the liner peeling force (peel strength to the second peeling liner) of the second adhesive surface of the double-sided adhesive sheet is preferably less than 1 N / 50 mm (for example, 0.5 N / 50 mm or less. (Less than 0.4 N / 50 mm). The double-sided pressure-sensitive adhesive sheet whose liner peeling force is limited to a specific value or less is easy to remove the peeling liner, and therefore has excellent workability during attachment. In addition, considering that the workability of the liner may be reduced if the liner release force is too small, the liner release force of the first adhesive surface and / or the liner release force of the second adhesive surface of the double-sided adhesive sheet is preferably about 0.01. N / 50 mm or more. Furthermore, in order to prevent the phenomenon that even one release liner is removed when one release liner is removed, it is preferable to make the peeling force of the first adhesive surface different from the peeling force of the second adhesive surface. In a state where the release liner is peeled in the order of the first release liner and the second release liner and an adhesive sheet is used, it is preferable to set the peel strength to the first release liner to be lower than that to the second release liner. Peel peel strength. The peeling force of the liner was measured in an environment of 23 ° C and 50% RH under conditions of a peeling angle of 180 degrees and a tensile speed of 300 mm / min in accordance with JIS Z 0237. More specifically, it measured by the method as described in the following example. In a preferred aspect of the double-sided adhesive sheet, in the bending resistance evaluation test performed by the following method, the floating distance (height) of the end portion is less than 3 mm (more preferably less than 1 mm). It is particularly preferable that the end portion does not float in the bending resistance evaluation test. In addition, in a preferred aspect of the double-sided adhesive sheet, in the paste overflow preventing property evaluation test performed by the following method, the amount of paste overflow is less than 0.1 mm (more preferably 0.09 mm or less, and still more preferably 0.06). mm or less). The adhesive sheet disclosed herein is in a preferred aspect. When the adhesive sheet is kept at 150 ° C for 30 minutes, the amount of toluene emitted from the sheet (toluene emission amount) can be 1 g per 1 g of the adhesive layer. It is 20 μg or less. The adhesive sheet in which the amount of toluene emission is suppressed to a specific value or less can be used comfortably because there is no unpleasant odor because the outgassing amount is suppressed. Such an adhesive sheet is particularly preferably used as a test piece for analyzing a biological sample (for example, a blood sample) for medical or health promotion purposes. The toluene emission amount is more preferably 10 μg or less per 1 g of the adhesive layer, and more preferably 3 μg or less (for example, 1 μg or less, typically 0.3 μg or less). What is necessary is just to use the value measured by the following method as said toluene emission amount. [Measurement of toluene emission amount] After cutting the adhesive sheet to a size of 1 cm × 1 cm, peeling off the release liner to expose the adhesive surface, the adhesive surface was adhered to an aluminum foil as a sample. After the sample was put into a 20 mL vial and fastened, the vial was heated at 150 ° C for 30 minutes, and 1.0 mL of a heated gas was injected into the gas phase layer by a headspace autosampler. The amount of toluene was measured in a GC measurement device, and the toluene emission amount (μg / g) per 1 g of the adhesive layer included in the sample was calculated. At this time, the gas chromatography conditions were set as follows.・ Carrier gas: Helium gas ・ Column: Non-polar capillary column ・ Column temperature: 10 ° C / min heating rate (low temperature) maintained after heating (low temperature) 40 ~ 300 ° C Column head pressure: 113 kPa (40 ° C) Detector: FID (flame ionization detector, flame ionization detector) (temperature 250 ° C). For quantification, a calibration curve can be prepared using a gas containing toluene with a known gas amount, and calculated based on the calibration curve. Specifically, as long as the total area of each peak that appears after the elapse of 20 minutes from the start of temperature rise until 20 minutes has elapsed is converted into a weight based on the calibration curve converted from toluene, the amount of toluene gas emission can be quantified. <Applications of the double-sided adhesive sheet> The double-sided adhesive sheet disclosed herein can be used for a test piece for analyzing a sample (test piece for sample analysis). In the present specification, a "test piece" is defined as a person (also referred to as a test strip) for analyzing a sample. For example, it may have a function of sampling (typically, collecting and / or holding) a sample. Typically, the test strips disclosed herein can be placed on components (components used in conjunction with measurement equipment) of various sample measurement equipment with analysis functions to perform sample analysis. The test piece may preferably be a sensor having a function of analyzing a sample (for example, a function of making information (such as a component concentration) from the sample into a detectable state using a chemical reaction or the like). Here, the sample to be analyzed is not particularly limited, and examples thereof include biological samples such as whole blood, plasma, serum, saliva, urine, and cerebrospinal fluid. In addition, the samples may be various foods or beverage water, drainage, rainwater, and the like. The shape of the sample is not particularly limited, and a sample that is liquid at normal temperature is preferred. In addition, the analysis purpose is not particularly limited, and for example, it can be the measurement of the concentration of a specific component in a sample such as the blood glucose concentration. When the sample is a blood sample, as the analysis target, in addition to the above-mentioned glucose, components such as albumin, lactic acid, bilirubin, and cholesterol can also be cited. The adhesive sheet in the technology disclosed herein can be preferably used for a test piece (hereinafter, also referred to as a biosensor) for analyzing a biological sample (preferably a blood sample). The sample analysis using the test piece can be performed, for example, by placing the test piece holding the sample in a sample measurement device. Such a sample measurement device may be, for example, a portable small-sized measurement device (for example, a biological sample measurement device) for medical or health promotion purposes. The test piece (for example, a medical test piece) disclosed herein may have a structure (shape, size, etc.) detachably connected to the biological sample measuring device as described above. Typically, such test strips can be disposable test strips (typically also referred to as stripes or chips). As an example of the use pattern of the above test piece, the use pattern described below can be cited: carry a box containing a plurality of test pieces and the above-mentioned measuring equipment, perform sample analysis at an appropriate point in time, and discard the used one Test strip. Hereinafter, referring to the drawings, the above-mentioned test piece (biosensor) for measuring the blood glucose concentration that is a suitable application target of the double-sided adhesive sheet disclosed herein and the above-mentioned adhesive sheet with a release liner disclosed herein A method for manufacturing a test piece will be described, but the technology disclosed herein is not limited to this. As shown in FIG. 3, the test piece 100 includes a substrate 110, a coating layer 120, and a double-sided adhesive sheet 11 disposed between the substrate 110 and the coating layer 120. The shape of the test piece 100 may be a long flat plate. In this embodiment, the substrate 110 is a resin substrate and has a laminated structure of a resin plate and an insulating layer. The surface of the substrate on which the following electrodes are to be formed may be made of an insulating material, or may be entirely made of an insulating material. Examples of the material constituting the substrate include polyester such as PET, polyolefin such as PE or PP, polyamide such as nylon, polycarbonate, polyimide, polystyrene, polymethyl methacrylate, and acrylonitrile-butyl. Organic materials (typically resins) such as diene-styrene resin (ABS resin), fluororesin, and inorganic materials such as glass. These can be used individually by 1 type or in combination of 2 or more types. On the surface of the substrate 110, the strip-shaped electrodes 116 are arranged in a stripe shape with a specific interval, thereby forming an electrode pattern on the surface of the substrate 110. The electrodes 116 are used to detect an electric current generated by a reaction between an analysis object and a reagent. The material of the electrode may be a conductive material, and for example, a carbon electrode can be preferably used. Since the electrode pattern is formed on the surface of the substrate 110 as described above, the surface of the substrate 110 has unevenness. The double-sided adhesive sheet 11 has the form of a double-sided adhesive sheet with a base material, which joins the substrate 110 and the coating layer 120 and also functions as a spacer between the substrate 110 and the coating layer 120. A U-shaped notch is provided on one end of the double-sided adhesive sheet 11 in the longitudinal direction of the test piece 100. The space formed by the notch (in other words, the space surrounded by the double-sided adhesive sheet 11 located around the notch and the substrate 110 and the covering layer 120 covering the upper and lower sides thereof) serves as one end in the longitudinal direction of the test piece 100 The function of the capillary portion 150 of the opening (sample introduction port) 152. A blood sample introduced from the opening 152 is held in the capillary portion 150. Moreover, in this embodiment, the width (also the width of the notch) of the capillary portion 150 is approximately 1 mm, and the depth of the capillary portion 150 is approximately 5 mm. The material of the coating layer 120 is not particularly limited, and an appropriate one can be selected from those exemplified as the material that can be used for the substrate 110 and used. Alternatively, a hydrophilic membrane made of a hydrophilic polymer such as CMC may be used from the viewpoint of improving analysis accuracy. In brief, the test strip 100 is used for analysis of a sample, for example, in the following manner. That is, a blood sample as an analysis target is introduced into the capillary portion 150 from the opening 152 located at one end of the test piece 100 by a capillary phenomenon. A reagent 180 is disposed inside the test piece 100 at a portion communicating with the capillary portion 150. In this embodiment, the reagent 180 is accommodated in the hole 160 formed in the double-sided adhesive sheet 11. When the reagent 180 is contained in the test strip 100, it is in a liquid state at normal temperature (for example, 25 ° C), and is in a state of being in a gel state after being processed in the following manner, or is contained in a dry state or contained in a layer Various forms such as states of members and the like are arranged in the test piece 100. The reagent 180 generates an electric current by performing an electrochemical reaction with an analysis object (typically glucose) in a blood sample introduced into the capillary portion 150. The test piece 100 in this state is placed in a test piece insertion port of a measuring device, and the current value generated by the above reaction is measured in the device, thereby calculating the glucose concentration in the blood sample. The reagent contained in the test piece can be appropriately selected and used by a well-known or conventional person who performs an electrochemical reaction or a color development reaction with the analysis object according to the analysis object. For example, in the case where the blood glucose concentration is measured as described above, a reagent containing an oxidoreductase and an electron transfer medium that react with glucose is used. The oxidoreductase that can be included in the reagent is not particularly limited, and examples of the analysis target include NADH (nicotinamide adenine dinucleotide hydride) oxidase (such as xanthase), ethanol Oxidase, glucose oxidase, glucose dehydrogenase, lactate oxidase, lactate dehydrogenase, cholesterol oxidase, bilirubin oxidase and the like. The electron transfer medium is also not particularly limited, and potassium ferricyanide, p-benzoquinone, brown &#134116; methyl sulfate, ferrocene derivative, etc. can be used depending on the enzyme used. The reagent may contain any additional components such as a water-soluble polymer and a filler. Typically, the reagent when the test piece is injected contains a solvent, and for example, it may be in the form of a solution containing the above components such as the oxidoreductase and the electron transport medium in the solvent. The solvent used for the reagent is not particularly limited, and examples thereof include water-based solvents and phosphoric acid containing water (distilled water, ultrapure water, etc.) as the main component (the most contained component, typically containing more than 50% by weight of the component). Buffers such as buffers, alcohols such as ethanol, organic solvents such as dimethylsulfine, and tetrahydrofuran. When the above reagent is used to manufacture a test piece, it is typically contained in the test piece by the following method. Specifically, as shown in FIG. 4, a double-sided adhesive sheet 11 having two adhesive surfaces covered with a release liner is prepared, and a release liner (here, the first release liner) is peeled to make an adhesive surface (here The first adhesive surface is exposed, and the exposed adhesive surface (first adhesive surface) is bonded to the substrate 110. As the pressure-sensitive adhesive sheet with a release liner used, for example, the pressure-sensitive adhesive sheet 1 with a release liner shown in FIG. 1 described above is used. In the adhesive sheet with a release liner (for example, the adhesive sheet 1 with a release liner in FIG. 1), a hole 160 penetrating at least the second release liner 32 and the double-sided adhesive sheet 11 is provided in advance, and the hole 160 is peeled off at the second time. The back surface 32B of the pad 32 is opened. At this time, the double-sided adhesive sheet 11 attached to the substrate 110 is in a state where the second adhesive surface (upper surface) is covered with the second release liner 32. In this state, the reagent 180 is injected into the test piece 1 from the back surface 32B of the second release liner 32. Specifically, the reagent 180 is injected into the hole 160 opened in the back surface 32B of the second release liner 32. Typically, the reagent 180 is injected in a liquid state. That is, when the reagent 180 cannot be injected into the hole 160 with high accuracy and the reagent 180 is attached to the back surface 32B of the second release liner 32 in this injection operation, the water on the back surface 32B of the second release liner 32 is facilitated. The contact angle is 70 ° or more. Therefore, the reagent remains on the back surface 32B of the second release liner 32 without loss of reagents. The residual uninjected reagent can be loaded into the well 160 by induction with a dropper or the like. After the reagent 180 is loaded into the hole 160, the second release liner 32 is peeled off from the double-sided adhesive sheet 11 and the coating layer is adhered to the second adhesive surface of the double-sided adhesive sheet 11, thereby obtaining a figure 3 The illustrated test piece 1 has a laminated structure including a substrate 110, a double-sided adhesive sheet 11 and a coating layer 120. Furthermore, a decorative layer or an adhesive layer (such as an adhesive layer) for fixing the decorative layer may be further provided on the coating layer (typically a hydrophilic film) on the test piece. The size of the test piece disclosed here is not particularly limited, as long as it is appropriately set according to the measurement equipment or the required sample size. For example, test pieces with a length of about 15 to 50 mm (for example, 20 to 40 mm), a width of about 3 to 15 mm (for example, 4 to 10 mm), and a maximum thickness of about 100 to 2000 μm (for example, 300 to 600 μm) can be compared. The double-sided adhesive sheet disclosed herein is preferably used. In addition, the distance between the substrate and the coating layer (that is, the thickness of the spacer) that affects the volume of the capillary portion is usually about 200 μm or less, preferably 120 μm or less (for example, 70 μm or less, typically 50 μm or less). The thickness of the spacer is, for example, the total thickness of the double-sided adhesive sheet in the configuration of the above embodiment. For example, a test piece having the structure described above is obtained by forming a plurality of electrode patterns on the surface of a sheet-like substrate, laminating the coating layer by double-sided adhesive sheets to obtain a laminated structure, and punching the laminated structure into a plurality of pieces (for example 10 or more). The electrode pattern can be formed by a known method such as screen printing as appropriate. The injection of the reagent into the test piece may be performed before the coating layer is laminated as described above. The punching process is performed using a known or conventional processing machine. The double-sided adhesive sheet used in the test piece preferably has a property of closely adhering to the electrode-forming substrate and the covering layer as an adherend without causing undesirable conditions such as peeling that may cause sample leakage (typically, adhesive force) , Reagent retention, etc.). For example, it is preferable to have the following degree of bending resistance: Even when a test piece collected with a sample is placed in a test piece insertion opening of a measurement device, the test piece is caught near the insertion opening and bent, The bonding state of the constituent members of the test piece is well maintained. Furthermore, it is expected that when the adhesive sheet for a test piece is subjected to the above-mentioned punching processing or when a plurality of test pieces integrated by punching processing are separated one by one (typically cutting), the adhesive does not overflow from the cut end surface. EXAMPLES Hereinafter, several examples related to the present invention will be described, but it is not intended to limit the present invention to those shown in the examples. In the following description, unless otherwise specified, "parts" and "%" are based on weight. <Evaluation method> [Water contact angle] The water contact angle on the back surface of the release liner (second release liner) was measured using a commercially available contact angle measuring device in accordance with JIS R 3257: 1999 under the following conditions. (Water contact angle measurement conditions) Measuring device: Contact angle measuring device FACE CA-X (manufactured by Kyowa Interface Chemical Co., Ltd.) Measuring environment: 23 ° C, 50% RH Measuring liquid: Distilled water Measuring time: 1500 ms after dropping [Surface free Energy] The surface free energy γ is given by: γ = γ ^d ＋ γ ^p ＋ γ ^h The value represented. Here, γ in the above formula ^d , Γ ^p And γ ^h Represents the dispersed component, polar component, and hydrogen bonding component of surface free energy. The free surface energy on the back surface of the release liner (second release liner) γ uses water, diiodomethane, and 1-bromonaphthalene as the detection liquid, and according to the contact angle of each detection liquid and according to the Kitasaki- 畑 style (Japan Adhesive Association) Vol.8, No.3, 1972, pp.131-141). The contact angle was measured using a commercially available contact angle meter. [180-degree peel strength] A release liner was peeled from the double-sided adhesive sheet with a release liner of each example to expose an adhesive surface, and a PET film having a thickness of 25 μm was adhered to the exposed adhesive surface. This was cut into a size of 20 mm in width and 150 mm in length as a sample for evaluation. The other release liner was peeled from the sample for evaluation, the other adhesive surface (adhesive surface of the measurement object) was exposed, and a 2 kg roller was reciprocated once at 23 ° C and 50% RH. The other adhesive surface is crimped to the surface of the adherend. After leaving it in the same environment for 30 minutes, a universal tensile compression tester (device name "TCM-1kNB", manufactured by Minebea) was used in accordance with JIS Z 0237 at a peeling angle of 180 degrees and a tensile speed of 300 mm / min. The conditions measured the peel strength (N / 20 mm width). A stainless steel plate (SUS304 plate) was used as the adherend. [Panel peeling force] The double-sided adhesive sheet with a release liner of each example was cut into a size of 50 mm in width and 150 mm in length as a sample for evaluation. This sample for evaluation was measured using a tensile tester (device name "TCM-1kNB", manufactured by Minebea) under conditions of 23 ° C and 50% RH at a peel angle of 180 degrees and a tensile speed of 300 mm / min. The peeling strength when the release liner was peeled from the adhesive surface of the double-sided adhesive sheet, and the highest value was set as the peeling strength (N / 50 mm width). The measurement was performed on both sides of the first adhesive surface (peeling force to the first release liner) and the second adhesive surface (peeling force to the second release liner). [Gel fraction of the adhesive layer] About 0.1 g (weight W1) of the adhesive was collected from each of the adhesive sheets, and a porous polytetrafluoroethylene (PTFE) film (weight W2) with an average pore diameter of 0.2 μm was used to form a purse. Shape, and use a kite string (weight W3) to fasten the mouth. The bundle was immersed in 50 mL of ethyl acetate and kept at room temperature (typically 23 ° C.) for 7 days, so that only the gel component in the adhesive layer was dissolved out of the film, and then the bundle was packaged. The package was taken out and the ethyl acetate adhering to the outer surface was wiped off, the package was dried at 130 ° C for 1 hour, and the weight of the package (W4) was measured. Each value was substituted into the following formula, and the gel fraction (%) of the adhesive layer was calculated | required. Gel fraction (%) = [(W4-W2-W3) / W1] × 100 As the porous PTFE membrane, a trade name "NITOFLON NTF1122" (average pore diameter 0.2 μm, porosity) available from Nitto Denko Corporation was used. 75%, thickness 85 μm). [Liquid recycling property] The double-sided adhesive sheet with a release liner in each example was cut into a size of 10 mm in width and 100 mm in length, the first release liner was peeled off, and a stainless steel (SUS) plate was attached to the exposed The first adhesive surface. With respect to the evaluation sample obtained as described above, as shown in FIG. 5, the evaluation sample 200 was placed on the 30-degree inclined surface with the SUS board 212 side facing downward. The evaluation sample 200 was arrange | positioned so that the longitudinal direction might become the up-down direction (inclined direction) of an inclined surface. One drop (approximately 3 to 5 μL) of pure water 220 was placed on the upper end of the back surface 216B of the second release liner 216 disposed above the evaluation sample 200, and a dropper was used to attach water droplets to the dropper. The front end slides 50 mm in a straight line facing downward (in the direction of the arrow in Fig. 5). In addition, in FIG. 5, reference numeral 214 denotes a double-sided adhesive sheet. The back side where the water droplets move easily becomes the back side where the reagents on the back surface of the release liner can be easily moved and the reagent can be recovered and injected. Therefore, when the total amount of water drops on the back surface 216B of the second release liner 216 can be moved The evaluation was "○", and when the total amount could not be moved, it was evaluated as "×". [Liquid retention] The double-sided adhesive sheet with a release liner of each example was cut into a size of 10 mm in width and 40 mm in length, and a hole having a diameter of 2 mm was formed on one end side in the length direction. Then, the first release liner was peeled from the double-sided adhesive sheet, and a white PET plate was attached to the exposed first adhesive surface. One drop (about 3 to 5 μL) of water colored in red (colored water) was dropped from the opening on the back of the second release liner into the hole of the evaluation sample obtained in the above manner, and as shown in FIG. 2 With the release liner 316 side up, the evaluation sample 300 was placed on a 30-degree inclined surface. The evaluation sample 300 is arranged so that the longitudinal direction becomes the up-down direction (inclined direction) of the inclined surface. After being left for one day in this state, the state of the colored water 320 in the hole 330 in the double-sided adhesive sheet 314 was observed. When the coloring water 320 does not leak from the hole 330, it is evaluated as "○", and when the coloring water 320 leaks from the hole 330 (that is, when it flows out between the PET plate 312 and the double-sided adhesive sheet 314), it is evaluated as "" × ". [Bending resistance] The double-sided adhesive sheet with a release liner in each example was cut into a width of 10 mm and a length of 50 mm, and a PET board cut to the same size and having a thickness of 100 μm was attached (substrate) to the peeling. The second adhesive surface exposed by the second release liner was a PET substrate double-sided adhesive sheet for evaluation. In addition, a copper film having a thickness of 50 μm was laminated on one surface of a resin plate (PET plate) having a thickness of 1 mm, and cut into a size of 10 mm in width and 70 mm in length to obtain a test adherend (Cu resin laminated plate). . The first release liner was peeled from the PET substrate double-sided adhesive sheet used for the test to expose the first adhesive surface, and the first adhesive surface and the test object were adhered using a laminator in an environment of 23 ° C and RH50% The center of the longitudinal direction of the copper film surface of the body was aligned and the two were crimped together, and this was used as a test piece. Next, as shown in FIG. 7, the test piece 400 was bent into an arc shape using a jig so that the chord length in the longitudinal direction of the test piece 400 became 50 mm. The test piece 400 was bent so that the side of the substrate PET plate 412 protruded. This was kept in the same environment for one day, and the state of the end of the double-sided adhesive sheet 414 of the test piece 400 was observed. When the double-sided adhesive sheet 414 followed the surface of the copper film 424 of the adherend 420 for test, it was evaluated as "○", and the end of the double-sided adhesive sheet 414 was bulged from the adherend 420 for test, and the peeling was confirmed. In the case, it was evaluated as "×". In FIG. 7, reference numeral 422 denotes a resin plate of the adherend 400 for testing. [Prevention of paste overflow] The double-sided adhesive sheet with a release liner in each example was cut into a size of 10 mm × 30 mm, a release liner was peeled off, and an acrylic resin plate was attached to the exposed adhesive surface. Then, the acrylic resin plate is placed so that the side becomes downward. The other release liner remained without being peeled off, and an aluminum plate was placed on the release liner to obtain an acrylic resin plate 512, a double-sided adhesive sheet 514, and a release liner 516 laminated in this order from the bottom as shown in FIG. 8. And an evaluation sample 500 made of an aluminum plate 520. For this evaluation sample 500, a pressure of 10 MPa (in the direction of the arrow in FIG. 8) was applied from above for 1 minute, and the paste immediately after the pressure was released was measured from the top by a microscope observation (adhesive for double-sided adhesive sheet 514). The maximum value (mm) of the overflow distance from the end face of the release liner. If the amount of overflow of the paste (the maximum value of the overflow distance) is 0.1 mm or more, the workability is reduced. Therefore, when the amount of overflow of the paste is less than 0.1 mm, it is evaluated as "○", and the amount of overflow is 0.1 mm. The above situation was evaluated as "×". <Example 1> (Preparation of Adhesive Composition (A)) 100 parts of BA, 5 parts of Vac, 3 parts of AA, and HEA were added to a reaction vessel equipped with a stirrer, thermometer, nitrogen introduction tube, reflux condenser, and dropping funnel. 0.1 part of AIBN as a polymerization initiator and toluene as a polymerization solvent were subjected to solution polymerization at 60 ° C. for 6 hours to obtain a toluene solution of an acrylic polymer (A). Mw of the acrylic polymer (A) was 55 × 10 ⁴ . Polymerized rosin pentaerythritol ester (trade name "HARITACK PCJ") is added to 100 parts of the acrylic polymer (A) contained in the toluene solution, based on the solid content. The softening point is 118 to 128. ℃) 10 parts, hydrogenated rosin glyceride (trade name "HARITACK SE10", manufactured by Harima Chemical Co., softening point 75-85 ° C) 10 parts, hydrogenated rosin methyl ester (trade name "Foralyn 5020F", manufactured by Eastman Chemical Co., Ltd.) ) 5 parts, 15 parts of terpene-modified phenol resin (trade name "SUMILITE RESIN PR-12603N", manufactured by Sumitomo Bakelite Co., Ltd.) 15 parts as an adhesion-imparting resin, and an isocyanate-based crosslinking agent (trade name "Coronate L", Tosoh 2 parts of the company) and 0.025 part of an epoxy-based cross-linking agent (trade name "TETRAD-C", manufactured by Mitsubishi Gas Chemical Co., Ltd.) as a cross-linking agent to obtain an acrylic adhesive composition (A). (Production of Adhesive Sheet) As a first release liner, a polyester release film (trade name "DIAFOIL MRF", manufactured by Mitsubishi Polyester Corporation) with a thickness of 38 μm, which had been subjected to a release treatment on one side to become a release surface, was prepared. In addition, one side (front side) was prepared with a polysiloxane-based peeling treatment agent (trade name "KS-3703T", manufactured by Shin-Etsu Chemical Co., Ltd., thermosetting addition molding) to be a peeling side, and the other side (back side) was prepared. Polysiloxane-based water-repellent treatment agent (trade name "KS-847T", manufactured by Shin-Etsu Chemical Industry Co., Ltd., thermosetting addition molding) was water-repellent treated to form a polyester release film with a thickness of 75 μm on the water-repellent surface. The second release liner. An adhesive composition (A) was applied to each of the release surface of the first release liner and the release surface of the second release liner, and dried at 100 ° C. for 2 minutes to form a 13 μm thick film on each release liner. Adhesive layer. The adhesive layer formed on the two release liners was bonded to the first and second sides of a PET substrate film (trade name "Lumirror", manufactured by Toray) with a thickness of 5 μm, respectively, to produce this example. A double-sided adhesive sheet with a substrate. The double-sided adhesive sheet is a double-sided adhesive sheet including a substrate, a first adhesive layer provided on a first surface of the substrate, and a second adhesive layer provided on a second surface of the substrate. The adhesive surface (first adhesive surface) of the adhesive layer is protected by the first release liner, and the adhesive surface (second adhesive surface) of the second adhesive layer is protected by the second release liner. <Example 2> A release film (brand name "FILMBYNA NT") manufactured by Fujimori Industries was used as the second release liner, and the same peeling treatment as in Example 1 was performed on the front side to obtain a release surface (front side) and Release film on the water repellent surface (back). Except for this, a double-sided adhesive sheet with a release liner of this example was obtained in the same manner as in Example 1. <Example 3> A water-repellent material (trade name "TOYAL LOTUS") manufactured by Toyo Aluminium Co., Ltd. was used as the second release liner, a water-repellent surface was provided, and the same peeling treatment as in Example 1 was performed on the front side. A release film with a release surface (front surface) and a water repellent surface (back surface). Except for this, a double-sided adhesive sheet with a release liner of this example was obtained in the same manner as in Example 1. <Example 4> (Preparation of Adhesive Composition (B)) To a reaction vessel equipped with a stirrer, a thermometer, a nitrogen introduction tube, a reflux condenser, and a dropping funnel were added 70 parts of BA as a monomer component, 30 parts of 2EHA, 3 parts of AA and 0.05 parts of 4HBA, 0.08 parts of AIBN as a polymerization initiator, and ethyl acetate as a polymerization solvent, and solution polymerization was performed at 65 ° C for 3.5 hours in a nitrogen gas stream to obtain an acrylic polymer (B) Its solution. A polymerized rosin ester (trade name "PENSEL D125", Arakawa), which is used as an adhesion-imparting resin, is formulated in the solution of the acrylic polymer (B) based on 100 parts of the acrylic polymer (B) based on the solid content. 30 parts of softening point (made by Chemical Industry Co., Ltd.) and 3 parts of isocyanate-based crosslinking agent (trade name "Coronate L", manufactured by Tosoh Corporation) to prepare an acrylic adhesive composition (B). (Production of Adhesive Sheet) As a first release liner, a polyester release film (trade name "DIAFOIL MRF", manufactured by Mitsubishi Polyester Corporation) with a thickness of 38 μm, which had been subjected to a release treatment on one side to become a release surface, was prepared. In addition, a polyester release film having a thickness of 75 μm that has been subjected to a peeling process on only one side (front side) to be a peeled side was prepared as a second release liner. An adhesive composition (B) was applied to each of the release surface of the first release liner and the release surface of the second release liner, and dried at 100 ° C. for 2 minutes to form a 13 μm thickness on each release liner. Adhesive layer. Except for this, a double-sided adhesive sheet with a substrate of this example was produced in the same manner as in Example 1. <Example 5> (Preparation of Adhesive Composition (C)) 95 parts of BA and 5 parts of AA as monomer components were added to a reaction vessel equipped with a stirrer, a thermometer, a nitrogen introduction tube, a reflux condenser, and a dropping funnel. 0.2 parts of AIBN as a polymerization initiator and toluene as a polymerization solvent were subjected to solution polymerization in a nitrogen gas stream at 60 ° C. for 6 hours to obtain a solution of an acrylic polymer (C). To the solution of the acrylic polymer (C) described above, 15 parts of an acrylic oligomer and an isocyanate-based crosslinking agent (trade name ""CoronateL" (manufactured by Tosoh Corporation) and 0.075 parts of an epoxy-based crosslinking agent (trade name "TETRAD-C", manufactured by Mitsubishi Gas Chemical Co., Ltd.) to obtain an acrylic adhesive composition (C). As the acrylic oligomer, one prepared by the following method was used. Specifically, 95 parts of cyclohexyl methacrylate, 5 parts of AA, and α-methylstyrene dimer were added to a reaction vessel equipped with a stirrer, a thermometer, a nitrogen introduction tube, a reflux condenser, and a dropping funnel. (Named "Nofmer MSD", manufactured by Nippon Oil Co., Ltd.) 10 parts, 10 parts of AIBN as a polymerization initiator, and toluene as a polymerization solvent, stirred in a stream of nitrogen for 1 hour to remove oxygen in the polymerization system, and then heated to The reaction was performed at 85 ° C. for 5 hours to obtain an acrylic oligomer having a solid content concentration of 50%. The weight average molecular weight of the obtained acrylic oligomer was 4,300. (Production of Adhesive Sheet) A double-sided adhesive sheet with a release liner of this example was obtained in the same manner as in Example 4 except that the adhesive composition (C) was used instead of the adhesive composition (B). After the double-sided adhesive sheet with a release liner of each of the examples obtained above was cured in an environment of 23 ° C. and 50% RH for 1 day, each of the double-sided adhesive sheets was subjected to the above-mentioned evaluation test. The results are shown in Table 1. [Table 1] As shown in Table 1, in the double-sided adhesive sheet with a release liner provided with the first release liner and the second release liner, Examples 1 to 3 in which the water contact angle on the back surface of the second release liner was 70 ° or more Adhesive sheet for liquid recovery. On the other hand, in Examples 4 and 5 in which the water contact angle on the back surface of the second release liner was less than 70 °, the liquid recyclability was unsatisfactory. Based on the results, it was found that the release liner with a release liner having a first release liner and a second release liner and a water contact angle of one of the back surface of the first release liner and the back surface of the second release liner was 70 ° or more. When the double-sided adhesive sheet is used in the manufacture of a test piece for sample analysis, the loss of reagents during the manufacture of the test piece can be prevented. In addition, the adhesive sheet of Examples 1 to 3 having a gel fraction of 25% to 55% can have both liquid retention and paste overflow prevention properties. In addition, it was confirmed that the bending resistance was also superior to those of Examples 4 and 5 outside the above-mentioned gel fraction. Based on the results, it was found that when the adhesive sheet having a gel fraction of 25% to 55% is used in a test piece for sample analysis, the reagent can be held well in the test piece. In addition, it is considered that the test piece using the above-mentioned adhesive sheet does not overflow the paste during punching or the like, and can maintain the joined state of the constituent members well even when the test piece is bent. The adhesive sheet satisfying the above characteristics is particularly suitable for the use of a test piece for sample analysis. The specific examples of the present invention have been described in detail above, but these are merely examples and do not limit the scope of patent application. The technology described in the scope of patent application includes various changes and modifications to the specific examples exemplified above. [Cross Reference] This case claims priority based on Japanese Patent Application No. 2016-78325 filed on April 8, 2016, the entire contents of which are incorporated herein by reference.

1‧‧‧ Adhesive sheet with release liner
2‧‧‧ Adhesive sheet with release liner
11‧‧‧ double-sided adhesive sheet
12‧‧‧ double-sided adhesive sheet
15‧‧‧ substrate
15A‧‧‧First side of substrate
15B‧‧‧The second side of the substrate
20‧‧‧ Adhesive layer
20A‧‧‧The first adhesive surface
20B‧‧‧ 2nd adhesive surface
21‧‧‧The first adhesive layer
21A‧‧‧The first adhesive surface
22‧‧‧Second adhesive layer
22A‧‧‧Second Adhesive Surface
31‧‧‧The first release liner
31A‧‧‧front of 1st release liner
31B‧‧‧Back side of 1st release liner
32‧‧‧ 2nd release liner
32A‧‧‧ Front side of 2nd release liner
32B‧‧‧Back side of 2nd release liner
100‧‧‧test piece
110‧‧‧ substrate
116‧‧‧electrode
120‧‧‧ Coating
150‧‧‧ Capillary section
152‧‧‧ opening
160‧‧‧hole
180‧‧‧ reagent
200‧‧‧ Evaluation sample
212‧‧‧SUS board
214‧‧‧Double-sided adhesive sheet
216‧‧‧The second release liner
216B‧‧‧Back side of 2nd release liner
220‧‧‧pure water
300‧‧‧ Evaluation sample
312‧‧‧PET board
314‧‧‧Double-sided adhesive sheet
316‧‧‧ 2nd release liner
320‧‧‧colored water
330‧‧‧hole
400‧‧‧test piece
412‧‧‧ substrate PET board
414‧‧‧Double-sided adhesive sheet
420‧‧‧ Test adherend
422‧‧‧resin board
424‧‧‧copper film
500‧‧‧Evaluation sample
512‧‧‧acrylic resin board
514‧‧‧Double-sided adhesive sheet
516‧‧‧ Release liner
520‧‧‧aluminum sheet

FIG. 1 is a schematic cross-sectional view showing the structure of an adhesive sheet with a release liner (a double-sided adhesive sheet with a substrate) according to an embodiment. FIG. 2 is a schematic cross-sectional view showing the structure of an adhesive sheet with a release liner (a double-sided adhesive sheet without a substrate) according to another embodiment. Fig. 3 is a schematic perspective view showing the structure of a test piece according to an embodiment. FIG. 4 is a schematic perspective view showing the structure of a test piece in production. FIG. 5 is a schematic side view for explaining a method of a liquid recyclability evaluation test. Fig. 6 is a schematic side view for explaining a method of a liquid retention evaluation test. FIG. 7 is a schematic cross-sectional view for explaining a method for evaluating a bending resistance. FIG. 8 is a schematic side view for explaining a method for evaluating a paste overflow prevention property.

1‧‧‧ Adhesive sheet with release liner

11‧‧‧ double-sided adhesive sheet

15‧‧‧ substrate

15A‧‧‧First side of substrate

15B‧‧‧The second side of the substrate

21‧‧‧The first adhesive layer

21A‧‧‧The first adhesive surface

22‧‧‧Second adhesive layer

22A‧‧‧Second Adhesive Surface

31‧‧‧The first release liner

31A‧‧‧front of 1st release liner

31B‧‧‧Back side of 1st release liner

32‧‧‧ 2nd release liner

32A‧‧‧ Front side of 2nd release liner

32B‧‧‧Back side of 2nd release liner

Claims (8)

An adhesive sheet with a release liner, which is used for manufacturing a test piece for analyzing a sample, includes: a double-sided adhesive sheet having an adhesive layer; and a first release liner covering the adhesive. A first adhesive surface of the sheet; and a second release liner covering the second adhesive surface of the adhesive sheet; and water contact between one of the back surface of the first release liner and the back surface of the second release liner The angle is 70 ° or more. For example, the adhesive sheet with a release liner of claim 1, wherein the gel fraction of the adhesive layer is 25% to 55%. For example, the adhesive sheet with a release liner of claim 1 or 2, wherein the adhesive surface of the above adhesive sheet exhibits a 180-degree peel strength of 7 N / 20 mm or more. For example, the adhesive sheet with a release liner according to any one of claims 1 to 3, wherein the adhesive sheet is a double-sided adhesive sheet with a base material, which includes a base material and a first adhesive agent provided on one side of the base material. Layer, and a second adhesive layer provided on the other side of the substrate. The adhesive sheet with a release liner according to any one of claims 1 to 4, wherein the adhesive layer is an acrylic adhesive layer including an acrylic polymer as a base polymer. The pressure-sensitive adhesive sheet with a release liner according to claim 5, wherein the pressure-sensitive adhesive layer contains an adhesion-imparting resin in an amount of 20 to 60 parts by weight based on 100 parts by weight of the acrylic polymer. The adhesive sheet with a release liner according to any one of claims 1 to 6, wherein the thickness of the adhesive sheet is 50 μm or less. The adhesive sheet with a release liner according to any one of claims 1 to 7, wherein the test piece is a biosensor that is detachably connected to a biological sample measuring device.