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Priority to TW103133345ApriorityCriticalpatent/TWI634209B/en
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Publication of TWI634209BpublicationCriticalpatent/TWI634209B/en
Measuring Or Testing Involving Enzymes Or Micro-Organisms
(AREA)
Micro-Organisms Or Cultivation Processes Thereof
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Abstract
An in vitro co-culture system comprising cancer-associated fibroblasts (CAFs) and cancer cells for producing and maintaining cancer stem cells and uses for identifying agents capable of reducing cancer cell stemness. Also disclosed herein are a paracrine network through which CAFs facilitate production and/or maintenance of cancer stem cells and the use of components of such a paracrine network for prognosis purposes and for identifying cancer patients who are likely to respond to certain treatment.
TW103133345A2014-09-252014-09-25Cancer-associated fibroblasts in maintaining stemness of cancer stem cells
TWI634209B
(en)