TW201609078A - Drug solution-storing package and drug solution-storing container - Google Patents

Abstract

A main object of the present invention is to provide a multi-structured drug-solution storing package having an inner bag which can restrain an elution of impurities to a drug solution. The object is attained by providing a drug solution-storing package comprising a main bag having an inner bag consisting of an inner layer film and an outer bag consisting of an outer layer film, and an extracting member, wherein the main bag has a multi-layer structure, the multi-layer structure being a structure where the inner bag and the outer bag are overlapped; the inner bag and the outer bag have a part for heat-welding at which the multi-layer structure is welded in a state of one inner film and the other inner film are facing and overlapped; the inner film which has a fluoro resin containing film whose melting point is 230 DEG C or less placed on an outermost surface of the drug solution side; the outer film is a laminated film having a first outer film and a second outer film; the first outer film is a film for heat-welding and is capable of heat-welding to the inner film, placed on a side of the inner bag; and the second outer film is a film containing a resin whose melting point is same as the fluoro-containing resin of the inner film or higher, placed on an outer side of the main bag.

Description

Medicine liquid storage bag and drug liquid storage container

The present invention relates to a pharmaceutical liquid packaging bag having a multiple structure capable of suppressing elution of impurities into a chemical solution, and a medical liquid storage container using the same.

When the chemical liquid used in the industrial medicine field, the pharmaceutical product field, the cosmetic raw material field, and the like is stored and transported, a chemical liquid storage container such as a metal can is used. Since the chemical liquid is directly filled in the liquid medicine storage container, there is a concern that impurities such as particles existing inside the chemical liquid storage container may affect the chemical liquid. In addition, in order to remove the above-mentioned impurities, it is necessary to wash the inside of the container for storing the liquid medicine at a higher level, and there is a problem that the cost of recycling the container for storing the liquid medicine becomes high. Further, depending on the type of the chemical liquid, there is a problem that the inside of the chemical storage container itself is deteriorated. In the container for storing the chemical liquid, the liquid is supplied to the inside of the chemical storage container to apply pressure, and the chemical is taken out from the injection port. However, in this case, the nitrogen gas is in contact with the chemical solution. There is a problem that the viscosity of the chemical liquid changes due to the influence of nitrogen gas or the like, or the composition of the chemical liquid changes.

For the above-mentioned problems, for example, as shown in the patent documents 1 to 5, it is proposed to use a drug solution storage bag in the inside of the main body of the drug solution storage container. In the case of using the packaging bag for the liquid medicine storage, it is possible to suppress the deterioration of the inside of the main body of the liquid medicine storage container or the like. Moreover, when the chemical liquid is taken out from the inside of the chemical liquid storage container, nitrogen gas or the like is supplied to the main body. The liquid can be taken out from the outside of the packaging bag for the chemical liquid storage. Therefore, it is possible to prevent changes in composition, viscosity, and the like of the chemical solution caused by contact of the nitrogen gas with the chemical liquid.

As such a packaging bag for storing a chemical liquid, for example, as disclosed in Patent Documents 4 and 5, a double structure having an inner bag for storing a chemical liquid and a bag for covering the inner bag is proposed. The chemical liquid storage packaging bag having a double structure has a configuration in which the inner bag and the outer bag are each formed of a resin film, and have the following heat-welding portions, and the inner bag and the outer bag are integrated in the heat-welding portion; the heat-sealing portion A multilayer structure in which a resin film (hereinafter sometimes referred to as an inner layer film) constituting the inner bag is overlapped with a resin film constituting the outer bag (hereinafter sometimes referred to as an outer layer film) is used. The inner layer films are thermally welded to each other in such a manner as to face each other. When the packaging bag for the chemical liquid storage has a double structure, impact resistance and gas barrier properties can be improved.

Further, in the packaging bag for storing chemical liquid according to the double structure, in order to improve the adhesion between the inner layer film and the outer layer film at the heat fusion portion, the inner layer film and the outer layer film are preferably made of a polyolefin resin or the like. A laminated film of a film of a resin having heat fusion properties.

Further, in the packaging bag for storing a chemical liquid, since the inside of the inner bag is in direct contact with the chemical liquid, the inner layer film constituting the inner bag suppresses the incorporation of impurities into the chemical solution and the elution of the impurities into the chemical solution. From the viewpoint of the use, it is proposed to use a polyolefin without addition. However, in recent years, there has been an increasing demand for the use of various chemical liquids in packaging bags for liquid medicine storage, and it is desirable that the inner bag has a lower elution property of impurities into the chemical liquid.

[Previous Technical Literature] [Patent Literature]

[Patent Document 1] Japanese Patent Laid-Open No. Hei 9-95565

[Patent Document 2] Japanese Patent Laid-Open Publication No. Hei 5-505372

[Patent Document 3] Japanese Patent Laid-Open Publication No. 2009-539706

[Patent Document 4] Japanese Patent No. 4920678

[Patent Document 5] Japanese Patent No. 5008908

[Non-patent literature]

[Non-Patent Document 1] Hongxiang Teng, "Overview of the Development of the Fluoropolymer Industry", Appl. Sci. 2012, 2, 496 - 512; doi: 10. 3390/app2020496

The present invention has been made in view of the above circumstances, and a main object of the present invention is to provide a packaging bag for a chemical liquid storage having a plurality of structures capable of suppressing elution of impurities into a chemical solution, and a container for storing a chemical solution using the same.

In order to achieve the above object, the present invention provides a pharmaceutical liquid packaging bag comprising an inner bag including an inner layer film and containing a chemical liquid, and an outer layer film and disposed outside the inner bag. The bag body and the injection member joined to the bag body, wherein the inner bag and the outer bag have a plurality of layers in which the inner layer film and the outer layer film are superposed, and the inner layer films are opposed to each other a heat-welded portion that is welded in a state of being overlapped, wherein the inner layer film has a film containing a fluorine-containing resin having a melting point of 230 ° C or less on the outermost surface of the chemical liquid side, and the outer layer film is disposed on the inner bag side. a first outer layer film and a laminated film disposed on a second outer layer film on the outer side of the bag body, wherein the first outer layer film can be thermally welded to the inner layer film The film for thermal fusion bonding, wherein the second outer layer film comprises a film having a resin having a melting point equal to or higher than a melting point of the fluorine-containing resin of the inner layer film.

According to the invention, the inner layer film has a film containing a fluorine-containing resin, and the outer layer film has a film for heat fusion, whereby a packaging bag having a plurality of structures capable of suppressing the inner bag in which the impurities are eluted into the chemical liquid can be obtained.

In the above invention, the inner layer film may include only the film containing the fluorine-containing resin, and the film for heat fusion in the first outer layer film may be a film containing a fluorine-containing resin having a melting point of 230 ° C or lower. Since the inner layer film contains only the film containing the fluorine-containing resin, the elution of the impurities into the chemical liquid can be more effectively suppressed.

In the above invention, preferably, the bag body further includes an intermediate bag which is disposed between the inner bag and the outer bag and is formed of an intermediate film, and the multilayer structure of the heat-sealed portion has the inner layer film and the middle portion The film and the outer layer film have a structure, and the intermediate film has a film containing a fluorine-containing resin having a melting point of 230 ° C or lower. The strength of the packaging bag for storing a chemical solution of the present invention can be increased.

Further, in the above aspect of the invention, the inner layer film may be a first inner layer film having a fluorine-containing resin having a melting point of 230 ° C or less disposed on the chemical liquid side, and may be disposed on the outer bag side and may be included The laminated film of the second inner layer film of the resin which is thermally fused at a temperature equal to or lower than the melting point of the fluorine-containing resin, wherein the film for thermal fusion in the outer layer film is contained in the same manner as the melting point of the fluorine-containing resin A film of a resin that is thermally fused at or below the temperature. The inner layer film has the second inner layer film, and the thickness of the second inner layer film, the material, and the like can be selected to adjust the strength of the inner bag. Therefore, even when the thickness of the first inner layer film is made thinner, the strength of the inner bag can be ensured, and the amount of the relatively expensive fluorine-containing resin can be reduced to form a low-cost packaging bag. Moreover, the material of the outer layer film can be selected in a wide range.

In the above invention, preferably, the bag body further includes an intermediate bag which is disposed between the inner bag and the outer bag and is formed of an intermediate film, and the multilayer structure of the heat-sealed portion has the inner layer film and the middle portion The film and the outer layer film have a structure in which the intermediate film contains a resin which can be thermally welded at a temperature equal to or lower than a melting point of the fluorine-containing resin. The strength of the package of the present invention can be made high.

The present invention provides a container for a chemical liquid storage, which comprises an outer container and a packaging bag for storing a chemical liquid disposed in the outer container, wherein the medical liquid storage package has a bag body having An inner bag which is composed of an inner layer film and houses the chemical liquid, and a bag which is formed of an outer layer film and disposed outside the inner bag; and a dispensing member which is joined to the bag body; the inner bag and the outer bag have a multilayer structure in which the inner layer film and the outer layer film are superposed on a heat-sealed portion in which the inner layer films are welded to each other in a state of being opposed to each other, wherein the inner layer film has a melting point on the outermost surface of the chemical liquid side The film of the fluorine-containing resin having a thickness of 230 ° C or less, the outer layer film having a first outer layer film disposed on the inner bag side and a laminated film disposed on the outer side of the bag body, the first outer layer The film is a film for heat fusion bonding with the inner layer film, and the second outer layer film includes a film having a resin having a melting point equal to or higher than a melting point of the fluorine-containing resin of the inner layer film.

According to the present invention, it is possible to provide a liquid medicine storage container which can suppress the elution of impurities from the inner bag in the chemical storage bag into the chemical solution and store the chemical liquid.

The packaging bag for storing a chemical solution according to the present invention has an effect of providing a plurality of structures having an inner bag capable of suppressing elution of impurities into the chemical solution.

1‧‧‧Packing bag for medicine liquid storage (packaging bag)

2‧‧‧ bag body

3‧‧‧Note components

4‧‧‧Liquor storage container

5‧‧‧Outside container

21‧‧‧ inner pocket

21a‧‧‧ Inner film

22‧‧‧ outer bag

22a‧‧‧ outer film

23‧‧‧Hot welding joint

23X‧‧‧Hot weld joint

24‧‧‧Intermediate bag

24a‧‧‧ interlayer film

31‧‧‧Note outlet joint

32‧‧‧Note Export Installation Department

33‧‧‧ middle column

34‧‧‧ openings

35‧‧‧Note export ontology

36‧‧‧Bottom mounting ring

51‧‧‧ container body

52‧‧‧Gas Supply Department

53‧‧‧ fixed department

61, 62‧‧‧ nozzle

211‧‧‧1st inner film

212‧‧‧2nd inner film

221‧‧‧1st outer membrane

222‧‧‧2nd outer membrane

223‧‧‧ functional layer for outer film

311‧‧‧Cylinder

312‧‧‧Flange

321‧‧‧Installation column

322‧‧‧Plate ribs

323‧‧‧ slot department

351‧‧‧Cylinder

352‧‧‧Flange

Fig. 1 is a schematic view showing an example of a packaging bag for storing a chemical liquid according to the present invention.

Figure 2 is a cross-sectional view taken along line A-A of Figure 1.

Fig. 3 is an explanatory view for explaining the inside of the packaging bag for storing a chemical solution according to the present invention.

Fig. 4 is a schematic cross-sectional view showing another example of the packaging bag for storing a chemical liquid according to the present invention.

Fig. 5 is an explanatory view for explaining the inside of the packaging bag for storing a chemical solution of the present invention.

Fig. 6 is a schematic cross-sectional view showing another example of the packaging bag for storing a chemical liquid according to the present invention.

Fig. 7 is a schematic cross-sectional view showing another example of the packaging bag for storing a chemical liquid according to the present invention.

Fig. 8 is a schematic view showing another example of the packaging bag for storing a chemical liquid according to the present invention.

Fig. 9 is a schematic view showing another example of the packaging bag for storing a chemical liquid according to the present invention.

Fig. 10 (a) to (c) are explanatory views for explaining an example of the pouring member in the present invention.

11(a) to 11(c) are explanatory views for explaining another example of the pouring member in the present invention.

Fig. 12 is a schematic view showing another example of the packaging bag for storing a chemical liquid according to the present invention.

Fig. 13 is a schematic view showing another example of the packaging bag for medicinal liquid storage according to the present invention.

Figure 14 is a cross-sectional view taken along line A-A of Figure 13.

Fig. 15 is an explanatory view for explaining the inside of the packaging bag for storing a chemical solution according to the present invention.

Fig. 16 is a schematic cross-sectional view showing an example of a container for storing a chemical liquid according to the present invention.

Fig. 17 is a schematic cross-sectional view showing another example of the container for storing a chemical liquid according to the present invention.

FIG. 18 is an explanatory view for explaining a method of dispensing a chemical solution in the container for storing a chemical solution according to the present invention.

Fig. 19 shows the results of gas chromatography mass spectrometry analysis in the case of using dimethyl carbonate (DMC) in Reference Example 3.

Fig. 20 shows the results of gas chromatography mass spectrometry analysis in the case of using propylene glycol-1-monomethyl ether acetate (PGMEA) in Reference Example 3.

Hereinafter, the packaging bag for a chemical liquid storage and the container for storing a chemical liquid according to the present invention will be described.

The pharmaceutical liquid packaging bag (hereinafter sometimes referred to simply as a packaging bag) of the present invention includes an inner bag including an inner layer film and containing a chemical liquid, and an outer layer film and disposed outside the inner bag. The bag body of the outer bag and the injection member joined to the bag body, wherein the inner bag and the outer bag have a plurality of layers in which the inner layer film and the outer layer film are superposed, and the inner layer is a heat-sealed portion in which the films are welded to each other in a state of being opposed to each other, wherein the inner layer film has a film containing a fluorine-containing resin having a melting point of 230° C. or less on the outermost surface of the chemical liquid side, and the outer layer film is disposed on the film a first outer layer film on the inner bag side and a laminated film disposed on the outer side of the outer bag of the bag main body, wherein the first outer layer film is a film for thermal fusion bonding that can be thermally welded to the inner layer film, and the above The second outer layer film includes a film having a resin having a melting point equal to or higher than a melting point of the fluorine-containing resin of the inner layer film.

In the present invention, "splicing" generally means that a plurality of resin films facing each other are thermally welded. Further, in the present invention, "heat-sealing" means a plurality of opposing pieces. The surface of the resin film is melted and bonded by heating. By "heat-sealing", it is meant that a plurality of thermoplastic resin members are heated to a temperature exceeding a melting point and pressure is applied, whereby the above-mentioned resin members are bonded at a molecular level. In addition, the "heat-sealing temperature" means the heating temperature of the resin at the time of heat fusion.

In addition, the "temperature equivalent to the melting point of the fluorine-containing resin" means a temperature in the range of 0.9 times to 1.1 times the melting point of the fluorine-containing resin, and preferably a temperature in the range of 0.93 times to 1.07 times. .

According to the invention, the inner layer film has a film containing a fluorine-containing resin, and the outer layer film has a film for heat fusion, and can be formed into a packaging bag having a plurality of structures capable of suppressing the inner bag in which the impurities are eluted into the chemical liquid. Specifically, the inner layer film has a film containing the fluorine-containing resin on the outermost surface of the chemical liquid side, and the elution property containing the impurities in the chemical liquid can be disposed in the inner bag which is in direct contact with the chemical liquid. a film of a fluorine-containing resin. Further, since the first outer layer film is the film for thermal fusion bonding, the inner layer film and the first outer layer film can be welded to the heat fusion portion, so that the inner bag and the outer bag of the heat fusion portion can be integrated. Constructed bags. Further, the second outer layer film is a film containing a resin having a melting point equal to or higher than the melting point of the fluorine-containing resin, and the second outer layer side of the multilayer structure is produced even in the production of the packaging bag of the present invention. When the inner layer films and the inner layer film and the first outer layer film are thermally welded to each other by heating, the films may be at a temperature equal to or lower than the melting point of the resin contained in the second outer layer film. Since the heat fusion is performed, deterioration of the above second outer layer film can be suppressed.

The pharmaceutical liquid packaging bag of the present invention has three embodiments depending on the configuration of the inner layer film and the outer layer film. Hereinafter, an embodiment will be described.

Further, the film for heat fusion according to the present invention includes a film containing a fluorine-containing resin having a melting point of 230 ° C or lower, and may be equal to or lower than the melting point of the fluorine-containing resin. The concept of a film that is thermally fused at temperature.

I. First embodiment

The chemical liquid storage packaging bag according to the first aspect of the invention is characterized in that the inner layer film only has a film containing the fluorine-containing resin, and the heat-fusible film in the first outer layer film contains a melting point of 230 ° C or lower. A film of a fluorine-containing resin.

In other words, the pharmaceutical liquid packaging bag according to the first embodiment includes an inner bag including an inner layer film and containing the chemical liquid, and a bag main body including the outer layer film and disposed outside the inner bag. And the injection member joined to the bag body, wherein the inner bag and the outer bag have a plurality of layers in which the inner layer film and the outer layer film are superposed, and the inner layer films are overlapped with each other. a heat-welded portion to be welded underneath, wherein the inner layer film contains only a film containing a fluorine-containing resin having a melting point of 230 ° C or less, and the outer layer film has a fluorine-containing resin disposed on the inner bag side and having a melting point of 230 ° C or lower. The first outer layer film and the laminated film of the second outer layer film which is disposed on the outer side of the bag main body and which contains a resin having a melting point equal to or higher than the melting point of the fluorine-containing resin of the inner layer film.

The package for the first embodiment will be described using a diagram. Fig. 1 is a schematic view showing an example of a packaging bag according to a first embodiment, Fig. 2 is a cross-sectional view taken along line A-A of Fig. 1, and Fig. 3 is an explanatory view for explaining the inside of the packaging bag illustrated in Fig. 1. As shown in FIGS. 1 to 3, the packaging bag 1 has a bag body 2 having an inner bag 21 which is composed of an inner layer film 21a and houses a chemical liquid, and a bag which is composed of an outer layer film 22a and which covers the outer bag. 22; and the ejection member 3, which is engaged with the bag body. In addition, the inner bag 21 and the outer bag 22 have a plurality of layers in which the inner layer film 21a and the outer layer film 22a are stacked, and the heat seal portion 23 is welded to the inner layer film 21a so as to be opposed to each other. First embodiment In the sample, the inner layer film 21a contains only a film containing a fluorine-containing resin having a melting point of 230 ° C or less. Further, the outer layer film 22a has a laminated film of the first outer layer film 221 and the second outer layer film 222, and the first outer layer film 221 is disposed on the inner bag side and contains a fluorine-containing resin having a melting point of 230 ° C or less, and the second outer layer. The film 222 is disposed on the outer side of the bag body 2 and includes a resin having a melting point equal to or higher than the melting point of the fluorine-containing resin of the inner layer film 21a. The packaging bag 1 has a configuration in which the heat-sealed portion 23 has a heat-sealing surface 23X that thermally bonds the inner layer film 21a and the inner layer film 21a and the first outer layer film 221 in the multilayer structure, and the inner bag 21 and the outer portion The bag 22 is integrated. Moreover, the packaging bag 1 has a configuration in which the inner layer film 21a and the outer layer film 22a are disposed at intervals in a portion other than the heat sealing portion 23. In the packaging bag illustrated in FIGS. 1 to 3, an example in which one portion of the injection member 3 is joined between the inner layer films 21a in the heat fusion portion 23 is shown. Further, the portion shown by B in Fig. 1 indicates the double configuration of the package.

According to the first embodiment, the inner layer film contains only the film containing the fluorine-containing resin, and the first embodiment can be constituted only by the film containing the fluorine-containing resin having a low elution property into the chemical liquid. The inner bag of the bag that is in direct contact with the liquid medicine. Further, since the first outer layer film of the outer layer film is a film containing the fluorine-containing resin, the inner layer film and the first outer layer film can be thermally welded to the heat fusion portion, so that the inner layer film can be formed in the inner portion of the heat fusion portion. And a bag of multiple constructions in which the outer bag is integrated.

In the first embodiment, since the inner layer film only has the film containing the fluorine-containing resin, the elution of the impurities into the chemical liquid can be more effectively suppressed than in the packaging bag of the second embodiment described below.

Further, conventionally known are polytetrafluoroethylene (PTFE), perfluoroalkoxy fluororesin (PFA), ethylene-tetrafluoroethylene copolymer (ETFE), tetrafluoroethylene-hexafluoropropylene copolymer (FEP), and the like. A resin having a low solubility in a chemical solution as a fluorine-containing resin. However, the heat fusion temperature of the fluorine-containing resins is high. Therefore, in order to manufacture a packaging bag in which a film containing the fluorine-containing resin is applied to the inner layer film and disposed on the chemical liquid side of the inner bag, it is necessary to use the outer layer film as having an outer layer film. The resin which is thermally fused to the melting point of the temperature has a problem that the type of material which can be used for the outer layer film is greatly limited. Further, the fluorine-containing resin has a concern that thermal decomposition gas is generated by heating, and in particular, the higher the temperature, the more likely the toxic gas such as hydrogen fluoride is generated. Therefore, when a film containing a fluorine-containing resin such as PTFE is used for the inner bag, it is necessary to perform heat fusion at a high temperature, and therefore there is a concern that a toxic gas such as hydrogen fluoride is generated. In addition, there is a problem that the heating temperature becomes higher, and the load on the heat-sealing device such as a heat sealer is increased when the package is formed, or the energy consumed is also increased.

The melting point of the fluorine-containing resin is PTFE 317 ° C to 337 ° C, PFA 302 ° C to 310 ° C, ETFE 254 ° C to 279 ° C, and FEP 260 ° C to 282 ° C, all exceeding 250 (Non-Patent Document 1). Therefore, in the heat fusion which must be heated to exceed the melting point of the resin, it is necessary to heat to the above melting point or higher, so that the heat fusion temperature becomes high.

On the other hand, in the first embodiment, since the inner layer film is only a film containing a fluorine-containing resin having a melting point of 230 ° C or less, the toxicity can be suppressed in the production of the packaging bag of the first embodiment. The generation of high thermal decomposition gas can reduce the load on the heat fusion device and reduce the energy consumption. Hereinafter, the details of the packaging bag of the first embodiment will be described.

Bag body

The bag body in the first embodiment has an inner bag and an outer bag. Further, in the bag body in the first embodiment, the inner bag and the outer bag have heat fusion portions. Hereinafter, the details of the inner bag, the outer bag, and the heat seal portion will be described.

(1) inner bag

The inner bag in the first embodiment is composed of an inner layer film. Moreover, the inner bag is a person who stores a chemical liquid. The form of the inner bag is appropriately determined depending on the form of the packaging bag of the first embodiment.

(a) inner film

Hereinafter, the inner layer film used for the inner bag will be described. The inner layer film in the first embodiment contains only a film containing a fluorine-containing resin having a melting point of 230 ° C or less. The inner layer film in the first embodiment has a function of suppressing elution of impurities into the chemical solution in the inner bag.

A film containing a fluorine-containing resin (hereinafter sometimes referred to as a fluorine-containing resin film) used for the inner layer film will be described. Here, the "fluorine-containing resin" is a synthetic resin obtained by polymerizing a fluorine-containing olefin (ethylene hydrocarbon or unsaturated hydrocarbon). In the fluorine-containing resin, one of the resins may be partially graft-modified by a compound different from the above-mentioned fluorine-containing olefin. The quality of the modification is preferably from about 0.01% by mass to about 1% by mass. The film contains a fluorine-containing resin, and the content of the fluorine-containing resin is not particularly limited as long as the melting point of the inner layer film is equal to the melting point of the fluorine-containing resin, and the degree of elution of the impurities into the chemical solution is not particularly limited. The use of the liquid storage bag is appropriately selected. The content of the fluorine-containing resin in the film is, for example, 70% by mass or more, preferably 80% by mass or more, and particularly preferably 90% by mass or more. The higher the content of the fluorine-containing resin, the better the effect of suppressing the elution of impurities into the chemical solution is higher. Further, the melting point of the inner layer film can be measured by the same method as the method for measuring the melting point of the fluorine-containing resin described below.

The fluorine-containing resin film may contain only the fluorine-containing resin, and may further contain not containing Resin resin. It is more preferable to contain only a fluorine-containing resin from the viewpoint of suppressing elution of impurities into the chemical solution.

The inner layer film may be a fluorine-containing resin film, and a single layer of a fluorine-containing resin film is usually used. Further, the inner layer film may be, for example, a laminated film obtained by laminating a plurality of fluorine-containing resin films. In this case, the laminated film does not contain a resin film other than the fluorine-containing resin film.

(i) fluororesin

The fluorine-containing resin in the first embodiment is not particularly limited as long as the melting point is 230 ° C or lower. In other words, the melting point of the fluorine-containing resin in the first embodiment is not particularly limited as long as it is 230 ° C or lower, and is preferably in the range of 150 ° C to 230 ° C, particularly preferably in the range of 150 ° C to 220 ° C. Inside. The reason is that when the melting point of the fluorine-containing resin exceeds the above value, since the load for heating the outer layer film becomes large, it may become difficult to manufacture the package itself, or the type of resin which may be used for the outer layer film is affected. Larger limit. Moreover, when the packaging bag of the first embodiment is manufactured, the load on the relevant manufacturing apparatus is increased, or the thermal decomposition gas of the fluorine resin is likely to be generated. The melting point of the fluorine-containing resin is an endothermic peak of differential scanning calorimetry (DSC), which is measured by the method according to JIS K6935.

The fluorine-containing resin contained in the inner layer film may, more specifically, be polyvinyl fluoride (PVF), polyvinylidene fluoride (PVDF), polychlorotrifluoroethylene (PCTFE), or ethylene-tetrafluoroethylene- Hexafluoropropylene copolymer (EFEP), low melting point ETFE (LM-ETFE), and the like. In addition, examples of the commercially available products include Fluon (registered trademark) LM-ETFE manufactured by Asahi Glass Co., Ltd., and Neoflon (registered trademark) EFEP manufactured by Daikin Industries Co., Ltd. Among them, in the first embodiment, Good use LM-ETFE, EFEP. The melting point of LM-ETFE is, for example, 225 ° C, and the melting point of EFEP is, for example, 195 ° C. Therefore, in terms of a low melting point and easy heat fusion, it is LM-ETFE or EFEP. The fluorine-containing resin may be used alone or in combination of two or more.

(ii) a resin that is not a fluororesin

In the first embodiment, the fluorine-containing resin film may further contain a resin (other resin) which is not a fluorine resin, as needed.

Examples of the other resin include polyamine, polyester, ethylene-vinyl alcohol copolymer resin (EVOH), ethylene-methacrylic copolymer resin (EMAA), modified polyolefin, and low density polyethylene (LDPE). Wait. In a specific example of the resin which is not a fluorine-containing resin, a polyamine, an EVOH, or a modified polyolefin is preferable in terms of a high adhesion to a fluorine-containing resin.

Examples of the polyamines include nylon 6 (PA6) which is a polymer of ε-caprolactam, nylon 66 (PA66) which is a polymer of hexamethylenediamine and adipic acid, and polymerization of limonylamine as a polymer. Nylon 12 (PA12), nylon 11 (PA11) which is a polymer of eleven indoleamine, nylon 6/66 (PA6/66) which is a copolymer of PA6 and PA66, and the like. In the specific examples of the polyamines, PA6 is preferred as far as the melting point is close to the fluorine-containing resin. Further, the melting point of PA6 is, for example, 225 °C.

Examples of the polyester include polyethylene terephthalate (PET), polytrimethylene terephthalate (PPT), polybutylene terephthalate (PBT), and polyethylene naphthalate. (PEN), polybutylene naphthalate (PBN), and the like. In the specific examples of the polyesters, PBT is preferred in terms of the melting point and the fluorine-containing resin. The melting point of PBT is, for example, in the range of 232 ° C to 267 ° C.

As a commercially available product, for example, nylon manufactured by DuPont of Polyamide, Eval (registered trademark) manufactured by Kuraray Co., Ltd. of EVOH, and Admer manufactured by Mitsui Chemicals Co., Ltd. as a modified polyolefin (registered) Trademark), Modic (registered trademark) manufactured by Mitsubishi Chemical Corporation, Mersen G (registered trademark) manufactured by Tosoh Corporation, Hardlen (registered trademark) manufactured by Toyobo Co., Ltd., etc.

The content of the other resin in the fluorine-containing resin film is not particularly limited as long as the melting point of the inner layer film is equal to the melting point of the fluorine-containing resin, and the elution of impurities into the chemical liquid can be suppressed. The content of the other resin in the fluorine-containing resin film is appropriately adjusted depending on the content of the fluorine-containing resin.

(b) other

The thickness of the inner layer film is not particularly limited as long as it can suppress the elution of impurities from the inner bag into the chemical solution, and can be appropriately selected according to the use of the packaging bag of the first embodiment. The thickness of the inner layer film is, for example, in the range of 5 μm to 120 μm, preferably in the range of 5 μm to 110 μm, and more preferably in the range of 5 μm to 100 μm. The reason for this is that if the thickness of the inner layer film is too thin, the inner bag may be easily broken. Further, the reason is that it may become difficult to sufficiently thermally weld the inner layer films to each other in the heat fusion portion. Further, the reason is that it may become difficult to form the inner layer film well. Further, the reason is that if the thickness of the inner layer film is too thick, heat is hard to be transferred to the thickness direction of the multilayer structure in the production of the packaging bag of the first embodiment, so that it may become difficult to make the inner layer films mutually It is fully heat-sealed, or it may take more time to heat-seal. Moreover, the reason is that if the thickness of the inner layer film is too thick, the flexibility of the packaging bag may be lowered, or it may become difficult in the case of the container for the liquid medicine storage. Follow the outer container.

The method for forming the inner layer film can be the same as the method for forming a normal resin film, and examples thereof include a melt extrusion method. Examples of the method of forming the inner layer film using a plurality of resins include a melt kneading extrusion method in which a plurality of resins are melt-kneaded and homogenized, and then the molten resin is extruded from a die of the extruder to form a film. . Specific examples of the melt extrusion method and the melt kneading extrusion method include a T-die method using a T-die as a die or a circular die as a die and air is supplied thereto. Inflatable inflation method.

(2) outer bag

In the first embodiment, the outer bag is composed of an outer layer film. Moreover, the outer bag is disposed on the outer side of the inner bag. Here, the phrase "disposing the outer bag on the outer side of the inner bag" is a concept in which not only the outer bag is disposed so as to cover the inner bag, but also the inner bag is partially exposed from the outer bag. The form of the outer bag is appropriately determined depending on the form of the packaging bag of the first embodiment. Hereinafter, the outer layer film used for the outer bag will be described.

(a) outer film

In the first embodiment, the outer layer film has a laminated film of the first outer layer film and the second outer layer film. More specifically, in the outer layer film of the first embodiment, a layer is laminated on one surface of the first outer layer film to form a second outer layer film to constitute one film. Further, in the outer layer film, the second outer layer film may be formed directly on one surface of the first outer layer film, or the second outer layer may be formed on the surface of one of the first outer layer films via another layer. membrane.

(i) first outer membrane

The first outer layer film in the first embodiment includes a film of a fluorine-containing resin having a melting point of 230 ° C or lower. The first outer layer film is disposed on the inner bag side. The first outer layer film in the first embodiment has a function of thermally splicing the inner layer film in the inner bag with the outer bag to have a multi-layer structure.

The fluorine-containing resin to be contained in the first outer layer film is not particularly limited as long as the melting point is 230° C. or lower, and may be the same as the fluorine-containing resin contained in the inner layer film, or may be different from the fluorine-containing resin contained in the inner layer film. . In the first embodiment, it is preferable that the fluorine-containing resin contained in the first outer layer film is the same as the fluorine-containing resin contained in the inner layer film. This is because the inner layer film and the first outer layer film can be thermally welded to each other. Moreover, the fluorine-containing resin film which can be used as the first outer layer film may be the same as the fluorine-containing resin film used for the first inner layer film, or may be different from the fluorine-containing resin film used for the first inner layer film. The details of the fluorine-containing resin and the fluorine-containing resin film contained in the first outer layer film are the same as those described in the above item (1) (inner bag), and thus the description thereof is omitted.

The thickness of the first outer layer film is not particularly limited as long as it can be thermally welded to the inner layer film, and can be appropriately selected according to the use of the packaging bag of the first embodiment or the like. The thickness of the first outer layer film is, for example, in the range of 5 μm to 100 μm, preferably in the range of 5 μm to 80 μm, and more preferably in the range of 5 μm to 60 μm. This is because if the thickness of the first outer layer film is too small, it may become difficult to sufficiently thermally weld the inner layer film. Further, the reason is that it may become difficult to form a good film shape by laminating the second outer layer film described below. Moreover, when the thickness of the first outer layer film is too thick, heat is hard to be transmitted to the thickness direction of the multilayer structure during the production of the packaging bag of the first embodiment, and thus it may become difficult to make the inner layer film. And the first outer layer film is thermally welded, or it may become difficult to thermally weld the inner layer films to each other. Again, the reason is: It is possible to have more time for heat fusion.

(ii) second outer membrane

The second outer layer film in the first embodiment is a film which is disposed on the outer side of the bag body and includes a resin having a melting point equal to or higher than the melting point of the fluorine-containing resin of the inner layer film. Further, the second outer layer film is disposed on the outer side of the bag body. The second outer layer film in the first embodiment has a function of imparting a predetermined strength to the outer bag.

The resin to be contained in the second outer layer film is not particularly limited as long as it has a melting point equal to or higher than the melting point of the fluorine-containing resin of the inner layer film. The term "temperature equal to or higher than the melting point of the fluorine-containing resin of the inner layer film" means the above-mentioned "temperature equivalent to the melting point of the fluorine-containing resin" or a temperature higher than the temperature. The melting point of the resin contained in the second outer layer film is specifically 230 ° C or higher, preferably 230 ° C to 500 ° C, particularly preferably 230 ° C to 400 ° C, and more preferably Within the range of 230 ° C ~ 300 ° C. The reason for this is that when the melting point of the resin contained in the second outer layer film is less than the above value, when the inner layer film and the inner layer film and the first outer layer film are thermally welded, the heating load on the second outer layer film is caused. It becomes large, so it may become difficult to manufacture the package itself of the first embodiment. Moreover, there is a concern that the load on the manufacturing apparatus becomes large when the packaging bag of the first embodiment is manufactured, or the thermal decomposition gas of the fluorine-containing resin is likely to be generated. The melting point of the resin contained in the second outer layer film is measured by differential scanning calorimetry (DSC) to obtain an endothermic peak, and the value measured by the method according to JIS K6935 is used.

Specific examples of the resin contained in the second outer layer film include nylon (Ny), polyethylene terephthalate (PET), polybutylene terephthalate (PBT), and poly(naphthalene). Ethylene formate (PEN), polycarbonate (PC), polyimine, and the like. to When nylon or polybutylene terephthalate is used as the second outer layer film, impact resistance can be improved, and when nylon or polyethylene terephthalate is contained, gas barrier can be obtained. Sex has changed. As described above, according to the resin selection of the second outer layer film, the desired characteristics can be imparted to the outer bag. Moreover, when the packaging bag of the first embodiment is used for, for example, an electrolyte solution for accommodating a lithium ion battery, the second outer layer film is preferably PET or PBT. This is because the second outer layer film can be made to have a lower moisture content, and the deterioration of the electrolytic solution or the like can be more preferably suppressed.

The thickness of the second outer layer film is not particularly limited as long as it can be formed into a film shape by laminating the first outer layer film, and can be appropriately set to the outer bag, and can be appropriately used according to the use of the packaging bag according to the first embodiment. select. The thickness of the second outer layer film is, for example, in the range of 10 μm to 100 μm, and preferably in the range of 10 μm to 90 μm, particularly preferably in the range of 15 μm to 80 μm. This is because if the thickness of the second outer layer film is reduced, it may become difficult to impart sufficient strength to the outer bag. In addition, when the thickness of the second outer layer film is too large, heat is hard to be transmitted to the thickness direction of the multilayer structure in the heat fusion portion during the production of the packaging bag of the first embodiment, and thus it is possible to become It is difficult to sufficiently thermally weld the inner layer film and the inner layer film and the first outer layer film.

(iii) Functional layer for outer film

In the first embodiment, the outer layer film is not particularly limited as long as it has the first outer layer film and the second outer layer film. For example, as shown in FIG. 4, the first outer layer film 221 and the second outer layer film 222 may be used. There is a functional layer 223 for the outer film. The outer film 22a is a laminated film having the outer layer film functional layer 223, and the outer bag can be given a predetermined function.

As a function of the functional layer for the outer layer film, for example, ultraviolet absorption is exemplified. Light absorption function at specific wavelengths such as light, barrier function against gas, moisture, etc., impact resistance function, antistatic function, etc.

The material used as the functional layer for the outer layer film may be a resin material or an inorganic material. Examples of the resin material include PET, PBT, Ny, polyethylene (PE), polyvinyl alcohol (PVA), ethylene-vinyl acetate copolymer (EVA), and ethylene-vinyl alcohol copolymer (EVOH). Further, examples of the inorganic material include aluminum, aluminum oxide, cerium oxide (transparent vapor deposition), and the like.

The thickness of the functional layer for the outer layer film is not particularly limited as long as it can provide a predetermined function to the outer layer film and can be formed between the first outer layer film and the second outer layer film, and is in the range of 10 μm to 100 μm. Preferably, it is in the range of 10 μm to 80 μm, and more preferably in the range of 10 μm to 60 μm. The reason for this is that when the thickness of the functional layer for the outer layer film is too thick, the formability of the outer bag may be lowered, or the flexibility of the outer bag may be lowered. Further, the reason is that when the thickness of the functional layer for the outer layer film is too thin, it may become difficult to form a functional layer for the outer layer film to impart a desired function to the outer layer film.

The method for forming the functional layer for the outer layer film is not particularly limited as long as it is a method for forming a functional layer for a film having a predetermined function between the first outer layer film and the second outer layer film. For example, when the functional layer for the outer layer film contains a resin, the method described in the method for forming the outer layer film described below can be used. Further, for example, when the functional layer for the outer layer film is made of an inorganic material, for example, a vapor deposition method such as a vacuum deposition method or a sputtering method can be used.

(iv) outer film

In the first embodiment, the outer layer film has the above first outer layer film and second outer layer film Laminated film. The thickness of the outer layer film is not particularly limited as long as it can impart a predetermined strength to the outer bag, and can be appropriately selected according to the use of the packaging bag of the first embodiment and the like. The thickness of the outer layer film is, for example, in the range of 15 μm to 150 μm, preferably in the range of 20 μm to 130 μm, and more preferably in the range of 20 μm to 100 μm. The reason for this is that when the thickness of the outer layer film is too thin, there is a possibility that the outer bag is broken due to the weight of the chemical liquid when the bag is filled with the chemical liquid outside the packaging bag of the first embodiment. Further, the reason is that when the thickness of the outer layer film is too thick, it may become difficult to manufacture the packaging bag of the first embodiment. Moreover, the reason is that there is a possibility that the flexibility of the packaging bag is lowered, and it becomes difficult to follow the container for storing the chemical liquid.

The method for forming the outer layer film is not particularly limited as long as it is a method of laminating the first outer layer film and the second outer layer film, and it can be the same as the method of forming a normal laminated film. Examples of the method for forming the outer layer film include a co-extrusion method using an inflation method, a co-extrusion method such as a co-extrusion method using a T-die method, and the like, using a multilayer die as a die of an extruder. A co-extrusion lamination molding method in which a resin is simultaneously supplied, an extrusion coating lamination method in which a resin is melted and extruded from a T-die film in a film form including a different resin, and an adhesive is used. Dry lamination method, etc. Further, for example, the first outer layer film and the second outer layer film are formed separately, and the both are opposed to each other, and the outer layer film can be formed by thermocompression bonding by a hot press. In the first embodiment, a coextrusion method using an inflation method is preferred. In order to form the outer layer film into a tubular shape, the first outer layer film and the second outer layer film are formed into a tubular shape, and heat-welded portions are formed at both ends of the tube, whereby the portion to be thermally welded can be reduced to form a packaging bag.

The combination of the resin contained in the first outer layer film and the second outer layer film (resin of the first outer layer film/resin of the second outer layer film) is not particularly limited, and for example, EFEP/PBT, EFEP/PA66, and LM are preferable. - ETFE/PBT, LM-ETFE/PA66. Such The buildup film can be formed, for example, by a co-extrusion laminate molding method.

(b) other

In the first embodiment, the outer bag covers the inner bag, and protects the inner bag from impact, friction, and the like from the outside of the package of the first embodiment. In the outer bag, a first outer layer film is disposed on the inner bag side, and a second outer layer film is disposed on the outer side of the bag body.

(3) Intermediate bag

In the packaging bag according to the first embodiment, as shown in FIGS. 5 to 7, the bag body 2 further includes an intermediate bag 24 which is disposed between the inner bag 21 and the outer bag 22 and which is constituted by the intermediate film 24a. In this case, the multilayer structure of the heat-welding portion 23 described below has a structure in which the inner layer film 21a, the intermediate film 24a, and the outer layer film 22a are overlapped. Further, the intermediate film 24a is characterized in that it has a film containing a fluorine-containing resin which can be thermally welded at a temperature of 230 ° C or lower. Further, the intermediate bag 24 is usually disposed so as to cover the inner bag 21 and be covered by the outer bag 22. In addition, FIG. 5 is an explanatory view explaining the inside of the packaging bag for storing a chemical liquid according to the first embodiment. In addition, FIG. 6 and FIG. 7 are schematic cross-sectional views showing another example of the packaging bag for storing a chemical liquid according to the first embodiment.

In the first embodiment, the strength of the package can be made higher by having an intermediate bag.

The interlayer film has a film containing a fluorine-containing resin having a melting point of 230 ° C or less, and more specifically, a film containing the fluorine-containing resin on the surface on the inner bag side and the outer bag side. As the intermediate film 24a, for example, as shown in FIG. 6, only the film containing the fluorine-containing resin may be contained, and for example, as shown in FIG. 7, the first intermediate portion containing the fluorine-containing resin may be used. The film 241, the functional layer 242 for the interlayer film, and the first layer containing the fluorine resin 2 A laminated film in which three layers of the intermediate film 243 are laminated.

When the intermediate film contains only a film containing a fluorine-containing resin, the type of the fluorine-containing resin and the thickness of the intermediate film may be the same as those described in the above-mentioned inner layer film, and thus the description thereof is omitted. Description. In the case where the interlayer film is a laminated film of the above three layers, the functional layer for the interlayer film may be the same as that described in the section of the functional layer for the outer layer film. In addition, the first intermediate film and the second intermediate film may be the same as those described in the item of the first outer layer film, and thus the description thereof will be omitted.

Further, the intermediate bag in the first embodiment may be disposed between the inner bag and the outer bag, or may be arranged in two or more. That is, the package of the first embodiment may have a three-layer structure or may have multiple configurations of the above.

(4) Heat fusion joint

In the first embodiment, the inner bag and the outer bag have heat fusion portions. In the heat-welding portion according to the first embodiment, the multilayer structure in which the inner layer film and the outer layer film are superposed is formed such that the inner layer films are welded to each other in a state of being opposed to each other. The layers are thermally fused in a state in which the layers are opposed to each other. Further, in the package of the first embodiment, the heat-sealed portion is a portion in which the inner bag and the outer bag are integrated.

In the heat-welding portion in the first embodiment, two multilayer structures are usually disposed such that the inner layer films face each other. Further, in the heat-sealed portion, as shown in FIG. 2, the inner layer film 21a and the inner layer film 21a and the first outer layer film 221 are thermally welded to each other, and the heat-welded surface 23X is provided.

The position at which the heat-welded portion is formed can be appropriately selected depending on the form of the inner layer film and the outer layer film. For example, when the inner film and the outer film are in the form of a sheet, the preparation sheet is prepared. When two sheets of the inner layer film and the outer layer film are formed so as to overlap each other with the inner layer film facing each other and the multilayer structure is overlapped with each other, as shown in FIG. 8, the periphery of the packaging bag 1 can be surrounded. The heat fusion joint 23 is formed on the four sides. Further, when one sheet of the inner layer film and the outer layer film are prepared, and the inner layer film and the outer layer film are folded and the multilayer structure is overlapped, as shown in FIG. The three sides form a heat seal portion 23. Further, when the inner layer film and the outer layer film are tubular, as shown in FIGS. 1 to 3, the inner layer film 21a and the outer layer film 22a may be arranged concentrically, and the tube body may be end portions. The two sides form a heat seal portion 23. 8 and 9 are schematic views showing another example of the packaging bag according to the first embodiment, and the symbols which are not described are the same as those described in FIG. 1 and the like, and therefore are omitted here. Description. In addition, in FIGS. 8 and 9, the inner bag is omitted for convenience of explanation.

Further, in the heat-sealed portion, the portion provided at the inner edge corner portion of the bag body may be formed in an arc shape as shown in FIG. 1 or the like, or may be formed in a linear shape, but is not shown. When the inner edge corner portion of the heat-sealed portion is formed in an arc shape, it is possible to make it difficult for the chemical liquid to remain at the inner edge corner portion.

Further, when the injection member is joined to one of the heat fusion portions as described below, the heat fusion portion 23 may have a width in the joint portion with respect to the discharge member 3 as shown in FIG. X1 is formed in a tapered shape in such a manner that the width x2 of both ends becomes larger.

The width of the heat-sealed portion is not particularly limited as long as the inner layer film and the inner layer film and the first outer layer film are thermally welded, and may be appropriately selected depending on the use of the packaging bag or the like. The width of the heat-sealing portion is, in particular, in the range of 5 mm to 40 mm, preferably in the range of 5 mm to 35 mm, and particularly preferably in the range of 5 mm to 30 mm. The reason is that when the width of the heat-welding portion is too small, there is It may become difficult to obtain sufficient sealing strength. When the width of the heat-sealed portion is too large, the size of the entire bag must be enlarged in order to secure the volume inside the bag, and thus the handleability may be lowered. The width of the heat-welded portion refers to the minimum width of the heat-welded portion.

The adhesive strength of the inner layer film in the heat-fusible portion and the heat-welding surface of the inner layer film and the first outer layer film is such that the chemical liquid can be stored and held inside the packaging bag of the first embodiment. Further, it is not particularly limited and may be appropriately selected according to the use of the packaging bag of the first embodiment. The adhesive strength of the heat-fusible surface of the inner layer film in the heat-sealed portion is, for example, 15 N/15 mm or more, preferably 20 N/15 mm or more, and particularly preferably 30 N/15 mm or more. The reason for this is that when the strength is too small, the bag may be broken due to the weight of the chemical liquid contained in the inside of the packaging bag of the first embodiment. Moreover, as the above-mentioned adhesive strength, for example, it is preferably 80 N/15 mm or less. The reason for this is that it is easy to adjust the heat fusion time and the heating temperature at the time of manufacture of the packaging bag of the first embodiment. The above-mentioned adhesive strength can be measured by a T-peel peeling strength test in which the width of the measurement sample is set to 15 mm and the width of the measurement sample is set to 15 mm in accordance with JIS Z0238.

The method of forming the heat-fusible portion is not particularly limited as long as the inner layer film and the inner layer film and the first outer layer film are welded in the multilayer structure, and the heat can be used for processing the usual heat-fusible film. The method of welding is the same. Specific examples of the heat fusion bonding method include an ultrasonic welding method in which ultrasonic vibration of about 15 kHz to 50 kHz is applied to a film (member) together with pressure, whereby the film is heated by frictional heat generated in the film. a method of joining; a vibration welding method, which uses a lower frequency of about 100 Hz to 300 Hz to transmit a lateral vibration having a large amplitude to a film, thereby heating the film by friction heat generated in the film; Fusion The method uses a method in which an electromagnetic induction coil is used to electromagnetically flow a current through a body that is physically separated, and a film is heated by induction heating generated by a film; a high-frequency welding method uses high-frequency energy. The electric field acts to heat the film itself from the inside, thereby heating the film to join the film; the semiconductor laser welding method superimposes and illuminates the light transmissive resin and the light absorbing resin at an appropriate pressure a laser, wherein the absorption resin generates heat to generate light, and the film is heated by the light heating to bond the film; and the hot plate welding method directly presses the hot plate heated by the heater against the film. A method of bonding a film by heating by a function of heat conduction, and a method of bonding a heating wire to a film by a pulse welding method, and instantaneously flowing a large current to heat the heating wire to heat the film and bonding the film; a soldering iron type welding method in which a heating plate called a soldering iron is inserted between opposing films, thereby heating the film and bonding by pressure of the roller; Welding method, a film was fixed, so that rotation of the other film sheet and pressurized, whereby the friction heat generated in the use of the contact surface of the film joining method of heating and the like. In the above method of heat fusion, it is preferable to use a hot plate welding method, a pulse welding method, or a soldering iron welding method in terms of a large amount of melting of the film to stabilize the state of welding or high productivity. Specific examples of such preferred methods of thermal fusion are also collectively referred to as heat sealing.

The heat sealing machine used for heat sealing can be set as a well-known method.

(5) bag body

The bag system of the first embodiment has the above inner bag and outer bag. The form of the bag body in the first embodiment can be appropriately selected according to the use of the packaging bag according to the first embodiment, and is not particularly limited, and can be the same as that used in a normal packaging bag, and thus is omitted. The description here. The bag system of the first embodiment usually has The double constructor of the inner bag and the outer bag. Further, in the case of having the above intermediate bag, a multiple structure can be produced.

2. Injection component

The ejection member in the first embodiment is joined to the bag body described above. Further, the ejection member in the first embodiment is for providing an outlet member for connecting the inside of the inner bag to the outside of the package in the package.

As a form of such a pouring member, a known member can be used as a pouring member used for a packaging bag. Fig. 10 (a) is a schematic view showing an example of the injection member used in the first embodiment, Fig. 10 (b) is a cross-sectional view taken along line AA of Fig. 10 (a), and Fig. 10 (c) is from Fig. 10 (a) A schematic plan view of the B direction. As shown in Fig. 10 (a) to (c), for example, the injection member 3 includes an injection port joint portion 31 disposed outside the packaging bag, and the injection member 3 is attached to the injection port mounting portion of the bag body. 32; and the intermediate column portion 33 in which the injection port joint portion 31 and the spout attachment portion 32 are joined. Further, the injection member 3 has an opening portion 34 through which the injection port joint portion 31, the intermediate column portion 33, and the injection port attachment portion 32 are inserted. In the injection member 3 shown in FIGS. 10(a) to 10(c), for example, the injection port joint portion 31 has a tubular portion 311 having a bottom portion having a substantially U-shaped cross-sectional shape, and a self-cylindrical portion 311. A flange portion 312 that protrudes outward from the periphery of the upper end. Further, the intermediate column portion 33 has a tubular shape and is formed to have a diameter smaller than the diameter of the cylindrical portion 311 of the spout joint portion 31. The injection port mounting portion 32 has a cylindrical mounting post portion 321 continuously formed from the intermediate post portion 33 and a plate-like rib portion 322 disposed on a side surface of the mounting post portion 321 . Further, the injection port mounting portion 32 may have a groove portion 323. By having the groove portion, the resin of the inner layer film can enter the groove portion at the time of heat fusion, so that the bag body and the columnar member can be joined well. When the injection member is in the case of the above-described form, The injection member is generally joined to one of the heat seal portions 23 of the bag body 2 as shown in FIG. More specifically, the injection port mounting portion is disposed between the opposing inner layer films of the multilayer structure, and one of the inner layer films is thermally welded to the injection port mounting portion to be joined.

The details of the form of the above-described injection member can be, for example, the same as those described in Japanese Patent No. 5008908, and thus the description thereof will be omitted.

Fig. 11 (a) is a schematic view showing another example of the injection member used in the first embodiment, Fig. 11 (b) is a sectional view taken along line AA of Fig. 11 (a), and Fig. 11 (c) is a self-illustration A schematic plan view of the observation of the direction B in 11 (a). As shown in FIGS. 11(a) to 11(c), for example, as the injection member 3, there are provided a discharge port body 35 having a cylindrical portion 351 having a bottom portion and a bottom attachment ring 36. The bottom portion 352 is provided to be connected to the bottom of the tubular portion 351. An opening portion 34 is formed at the bottom of the tubular portion 351. When the injection member is in the above-described form, the injection member is generally joined to one of the side faces of the bag body 2 as shown in FIG. More specifically, a hole is formed at a partial position on the surface of the inner bag and the outer bag, and the spout body is inserted into the hole, and the inner layer film is welded to the bottom mounting ring to be joined. Moreover, as a welding method used in this case, an ultrasonic welding method, a solvent welding method, etc. are mentioned except the heat-welding method. Further, the inner layer film and the bottom mounting ring may be joined by, for example, an adhesive.

The details of the form of the above-described injection member can be, for example, the same as those described in Japanese Patent No. 4,920,678, and thus the description herein will be omitted.

As the material of the injection member, a resin is usually used. Further, since the injection member is preferably thermally bonded to the inner layer film and joined to each other, the material of the injection member preferably contains a fluorine-containing resin which can be thermally welded at 230 ° C or lower. Further, as the material of the injection member, it is more preferable to contain a fluorine-containing resin which is the same as the fluorine-containing resin contained in the inner layer film. The reason is that the two can be thermally welded well, and the package and the injection member can be made good. Ground joint.

Further, in the first embodiment, in the case where the fluorine-containing resin is used as the material of the injection member, the entire injection member may be composed of the fluorine-containing resin as long as at least the surface of the injection member contains the fluorine-containing resin. Alternatively, only the surface of the member to be injected may contain a fluorine-containing resin, and the other portion may be composed of a resin other than the above-mentioned fluorine-containing resin. In this case, examples of the resin other than the fluorine-containing resin include PE, PP, Ny, PET, and the like.

The method of forming the injection member can be the same as the method of forming the injection member of a normal packaging bag, and specifically, an injection molding method or the like can be given.

3. Other composition

The packaging bag according to the first embodiment is not particularly limited as long as it has the bag body and the injection member, and may be appropriately selected and added as needed. For example, a cover covering the injection member or the like can be cited.

4. Packaging bag

The packaging bag according to the first embodiment is usually disposed in an outer container in the liquid chemical storage container. The container for the liquid medicine storage is described in the item "B. Container for medicinal liquid storage" described below, and therefore the description herein is omitted.

The method for producing the packaging bag according to the first embodiment is not particularly limited, and can be the same as the method for producing a normal packaging bag. For example, an inner layer film and an outer layer film are separately prepared. Next, the inner layer film and the outer layer film are superposed to form a multilayer structure. Next, the multilayer structure is superposed so that the inner layer films face each other, and a part of the multilayer structure is heated from the outer side of the outer layer film, thereby causing the inner layer films and the inner layer film and the first layer 1 The outer layer film is thermally welded to form a heat fusion joint. In the above production method, it is preferred to wash the inner surface side of the inner layer film before the formation of the heat fusion portion. This is because the particles and the like adhering to the liquid medicine side of the inner bag in the first embodiment can be reduced, and the inner layer film after washing can be easily dried.

Examples of the chemical solution in which the packaging bag according to the first embodiment can be used include a photoresist, an etching solution, a chemical vapor deposition reagent, a solvent, a cleaning solution such as a wafer, and an electrolyte used for a lithium ion battery. Etc., but not limited to these.

II. Second embodiment

According to a second aspect of the invention, the inner layer film is a first inner layer film having a fluorine-containing resin having a melting point of 230 ° C or less disposed on the chemical liquid side, and is disposed on the a laminated film of a second inner layer film of a resin which can be thermally welded at a temperature equal to or lower than the melting point of the fluorine-containing resin, and the film for heat fusion in the outer layer film is included in the outer bag side. A film of a resin which is thermally welded at a temperature equal to or lower than the melting point of the fluorine-containing resin.

In other words, the pharmaceutical liquid packaging bag according to the second embodiment includes a bag including an inner layer film and containing an inner bag, and a bag body including an outer layer film and disposed outside the outer bag; And the injection member joined to the bag body, wherein the inner bag and the outer bag have a plurality of layers in which the inner layer film and the outer layer film are superposed, and the inner layer films are overlapped with each other. a heat-welded portion in which the inner layer is a laminated film of the first inner layer film and the second inner layer film, wherein the first inner layer film is disposed on the chemical liquid side and has a melting point of 230 ° C or less. a fluorine-containing resin, wherein the second inner layer is disposed on the outer bag side and includes a resin that can be thermally welded at a temperature equal to or lower than a melting point of the fluorine-containing resin, and the outer film is a laminated film of the first outer layer film and the second outer layer film, wherein the first outer layer film is disposed on the inner bag side and includes a resin that can be thermally welded at a temperature equal to or lower than a melting point of the fluorine-containing resin, The second outer layer film is disposed on the outer side of the bag body and includes a resin having a melting point equal to or higher than the melting point of the fluorine-containing resin.

The package of the second embodiment will be described using the drawings. Fig. 13 is a schematic view showing an example of a packaging bag according to a second embodiment, Fig. 14 is a sectional view taken along line A-A of Fig. 13, and Fig. 15 is an explanatory view for explaining the inside of the packaging bag illustrated in Fig. 13. As shown in FIG. 13 to FIG. 15, in the second embodiment, the inner layer film 21a is a laminated film of the first inner layer film 211 and the second inner layer film 212, and the first inner layer film 211 is disposed in the medicine. The liquid side contains a fluorine-containing resin having a melting point of 230 ° C or less, and the second inner layer film 212 is disposed on the outer bag 22 side and contains a resin which can be thermally welded at a temperature equal to or lower than the melting point of the fluorine-containing resin. . Further, the outer layer film 22a is a laminated film of the first outer layer film 221 and the second outer layer film 222, and the first outer layer film 221 is disposed on the inner bag 21 side and contains a temperature which is equal to or lower than the melting point of the fluorine-containing resin. The resin which is thermally fused, the second outer layer film 222 is disposed on the outer side of the bag body 2 and contains a resin having a melting point equal to or higher than the melting point of the fluorine resin. The packaging bag 1 has a heat-welding surface 23X in which the first inner layer film 211 and the second inner layer film 212 and the first outer layer film 221 in the multilayer structure are thermally welded to each other. The bag 21 and the outer bag 22 are integrated. Moreover, the packaging bag 1 has a configuration in which the inner layer film 21a and the outer layer film 22a are disposed at intervals other than the heat sealing portion 23. In addition, the symbols which are not illustrated in FIGS. 13 to 15 can be the same as those described in FIGS. 1 to 3 described above.

According to the second embodiment, the inner layer film is changed by the above laminated film. The first inner layer film containing a fluorine-containing resin having a low elution property of impurities in the chemical solution is disposed on the chemical liquid side of the inner bag. Further, since the inner layer film has the second inner layer film, and the outer layer film has the first outer layer film, the second inner layer film and the first outer layer film can be thermally welded to the heat fusion portion, so that the inner layer film can be formed into the heat fusion portion. The inner bag and the outer bag are integrated.

Further, according to the second embodiment, the inner layer film has the second inner layer film, and the thickness of the second inner layer film, the material, and the like can be selected to adjust the strength of the inner bag. Therefore, even when the thickness of the first inner layer film is made thinner, the strength of the inner bag can be ensured, and the amount of the fluorine resin which is relatively expensive can be reduced, and a low-cost packaging bag can be obtained.

As described in the section "I. First Embodiment", a fluorine-containing resin such as PTFE has a high melting point, and therefore there is a limitation of the material of the outer layer film, a concern of generation of a toxic gas during processing, and a large amount of energy consumed. And other issues. On the other hand, in the second embodiment, the fluororesin is contained in the first inner layer film, and a versatile resin film can be used for the outer layer film. Further, in the production of the packaging bag of the second embodiment, the generation of the highly decomposable pyrolysis gas can be suppressed, the load on the heat fusion device can be reduced, and the energy consumption can be reduced.

Hereinafter, the details of the packaging bag of the second embodiment will be described.

Bag body

The bag body in the second embodiment has an inner bag and an outer bag. Further, in the bag body in the second embodiment, the inner bag and the outer bag have heat fusion portions.

(1) inner bag

The inner bag in the second embodiment is composed of an inner layer film.

(a) inner film

In the second embodiment, the inner layer film is a laminated film of the first inner layer film and the second inner layer film. More specifically, in the inner layer film of the second embodiment, a layer is laminated on one surface of the first inner layer film to form a second inner layer film to constitute one film. Further, in the inner layer film, the second inner layer film may be formed by laminating directly on one surface of the first inner layer film, or may be layered on the surface of one of the first inner layer films via another layer. A second inner layer film is formed.

(i) first inner film

The first inner layer film in the second embodiment includes a film of a fluorine-containing resin having a melting point of 230 ° C or lower. Further, the first inner layer film is disposed on the chemical liquid side. Further, in the second embodiment, the first inner layer films are usually disposed to face each other and thermally welded. The first inner layer film in the second embodiment has a function of suppressing elution of impurities into the chemical solution in the inner bag.

The fluorine-containing resin film used for the first inner layer film can be the same as that described in the item "1. First embodiment" described above, and thus the description thereof will be omitted.

The thickness of the first inner layer film is not particularly limited as long as it can suppress the elution of the impurities in the inner bag into the chemical solution, and can be appropriately selected according to the use of the packaging bag of the second embodiment or the like. The thickness of the first inner layer film is, for example, in the range of 5 μm to 100 μm, preferably in the range of 10 μm to 80 μm, and more preferably in the range of 10 μm to 50 μm. The reason for this is that if the thickness of the first inner layer film is too small, it may become difficult to form a good film shape by laminating the second inner layer film. Further, the reason is that impurities from the second inner layer film may be dissolved in the chemical solution through the first inner layer film. Out. Moreover, the reason is that it may become difficult to sufficiently thermally weld the first inner layer films to each other in the heat fusion portion. Moreover, the reason is that it may become difficult to form the first inner layer film satisfactorily. Moreover, when the thickness of the first inner layer film is too thick, it may become difficult to sufficiently thermally weld the first inner layer films to each other, or there may be a large time required for heat fusion. Further, the reason is that the amount of the fluorine-containing resin used is increased, so that the cost of the packaging bag of the second embodiment is increased.

(ii) second inner film

The second inner layer film in the second embodiment includes a film of a resin which can be thermally welded at a temperature equal to or lower than the melting point of the fluorine-containing resin. Further, the second inner layer film is disposed on the outer bag side. Further, in the second embodiment, the second inner layer film and the first outer layer film are usually disposed to face each other and thermally welded. The second inner layer film of the second embodiment has a function of imparting a predetermined strength to the inner bag in the inner bag, and has a function of thermally welding the first outer layer film of the outer bag to have a double structure of the bag body. Moreover, in the case of having an intermediate pocket, the bag body can be constructed in multiple configurations.

The resin to be contained in the second inner layer film is not particularly limited as long as it can be thermally welded at a temperature equal to or lower than the melting point of the fluorine-containing resin, and the fluorine contained in the first inner layer film can be contained. The type of the resin or the like is appropriately selected. Here, the "temperature equal to or lower than the melting point of the fluorine-containing resin" means the above-mentioned "temperature equivalent to the melting point of the fluorine-containing resin" or lower than the temperature. The heat fusion temperature of the resin contained in the second inner layer film is, for example, preferably 230 ° C or lower, preferably 80 ° C to 230 ° C, and particularly preferably 80 ° C to 220 ° C. When the heat fusion temperature of the resin contained in the second inner layer film exceeds the above value, since the load for heating the outer layer film becomes large, it may become difficult to manufacture the package itself, or it is possible The resin that can be used for the outer film is greatly limited.

The resin to be contained in the second inner layer film is not particularly limited as long as it can be thermally welded at a temperature equal to or lower than the melting point of the fluorine-containing resin. Examples of such a resin include polyolefin resins such as polyethylene (PE) such as LDPE and polypropylene (PP). Also, a modified polyolefin can be used. In addition, as the resin contained in the second inner layer film, for example, EVOH or the like can be used. Further, in the second embodiment, it is preferred to use polyethylene, and it is preferred to use ultra-low-eluent polyethylene. This is because it is possible to preferably suppress impurities from the second inner layer film from passing through the first inner layer film and being mixed into the chemical liquid. For example, NOVATEC (registered trademark) LD (Japan Polyethylene Co., Ltd.), which is not added, may be used.

The thickness of the second inner layer film is not particularly limited as long as it is a layer which can be formed by laminating the first inner layer film to form an inner layer film, and the package according to the second embodiment can be used. Appropriate choice for use. The thickness of the second inner layer film is, for example, in the range of 10 μm to 100 μm, preferably in the range of 15 μm to 90 μm, and particularly preferably in the range of 20 μm to 80 μm. The reason for this is that if the thickness of the second inner layer film is too small, it may become difficult to form a favorable film shape by laminating the first inner layer film. Moreover, the reason is that it may become difficult to impart sufficient strength to the inner bag. Moreover, when the thickness of the second inner layer film is too thick, it may become difficult to thermally weld the second inner layer film, the first outer layer film, and the first inner layer film to each other. Moreover, the reason is that there is a possibility that the time required for heat fusion is large.

(iii) functional layer for inner film

In the inner layer film in the second embodiment, a functional layer for the inner layer film may be formed between the first inner layer film and the second inner layer film as needed. The functional layer for the inner layer film can be set to The contents described in the section of the functional layer for the outer layer film in the "I. First Embodiment" are the same, and therefore the description herein will be omitted.

(iv) inner film

The inner layer film in the second embodiment is a laminated film of the first inner layer film and the second inner layer film. The thickness of the inner layer film is not particularly limited as long as it can impart a predetermined strength to the inner bag, and can be appropriately selected according to the use of the packaging bag of the second embodiment or the like. The thickness of the inner layer film is, for example, in the range of 15 μm to 120 μm, preferably in the range of 20 μm to 110 μm, and more preferably in the range of 30 μm to 100 μm. The reason for this is that when the thickness of the inner layer film is too thin, or when the thickness of the inner layer film is too thick, the problems described in the item "I. First Embodiment" may occur.

The method for forming the inner layer film can be the same as the method for forming a normal laminated film. For example, the same method as the method for forming the outer layer film can be used.

The inner layer film may be a laminated film of the first inner layer film and the second inner layer film, or may be a laminated film of the first inner layer film, the inner layer film functional layer, and the second inner layer film, thereby reducing the manufacturing cost. From the point of view, it is better for the former.

The combination of the resin contained in the first inner layer film and the second inner layer film (resin of the first inner layer film/resin of the second inner layer film) is not particularly limited, and for example, EFEP/EVOH or LM is preferable. -ETFE/EVOH. In addition, the combination of the first inner layer film, the inner layer film functional layer, and the second inner layer film (resin of the first inner layer film / resin layer of the inner layer film functional layer / second inner layer film) Resin), for example, EFEP/PA6/modified polyolefin, EFEP/modified polyolefin/LDPE, EFEP/modified polyolefin/LDPE/EVOH/LDPE, LM-ETFE/PA6/modified polyolefin , LM-ETFE / modified polyolefin / LDPE, LM-ETFE / modified polyolefin / LDPE / EVOH / LDPE. Such The buildup film can be formed, for example, by a co-extrusion laminate molding method.

(b) inner bag

In the inner bag of the second embodiment, the first inner layer film is disposed on the chemical liquid side in the inner bag, and the second inner layer film is disposed on the outer bag side. That is, the first inner layer film is disposed inside the inner bag, and the second inner layer film is disposed outside the inner bag. The form of the inner bag is appropriately determined depending on the form of the packaging bag of the second embodiment.

(2) outer bag

In the second embodiment, the outer bag is composed of an outer layer film. Moreover, the outer bag is disposed on the outer side of the inner bag.

(a) outer film

In the second embodiment, the outer layer film is a laminated film of the first outer layer film and the second outer layer film. More specifically, in the outer layer film of the second embodiment, a layer is laminated on one surface of the first outer layer film to form a second outer layer film to constitute one film.

(i) first outer membrane

The first outer layer film in the second embodiment includes a film of a resin which can be thermally welded at a temperature equal to or lower than the melting point of the fluorine-containing resin. Further, the first outer layer film is disposed on the inner bag side. Further, in the second embodiment, the first outer layer film and the second inner layer film are usually disposed to face each other and thermally welded. The first outer layer film in the second embodiment has a function of thermally welding the second inner film of the inner bag to the inner bag so that the bag body has a double structure.

The resin to be contained in the first outer layer film is not particularly limited as long as it can be thermally welded at a temperature equal to or lower than the melting point of the fluorine-containing resin, and the fluorine-containing resin contained in the first inner layer film can be used. It is appropriately selected depending on the type and the like. The specific heat fusion temperature of the resin contained in the first outer layer film may be the same as that described in the item "(1) inner bag (a) inner layer film (ii) second inner layer film", Therefore, the description herein is omitted.

The resin contained in the first outer layer film is usually one that can be thermally welded to the resin contained in the second inner layer film. As the resin, a resin similar to the resin contained in the second inner layer film or a resin different from the resin contained in the second inner layer film may be used. In the second embodiment, the resin contained in the first outer layer film is preferably the same resin as the resin contained in the second inner layer film. This is because the first outer layer film and the second inner layer film can be thermally welded well. Moreover, the resin film which can be used as the first outer layer film may be the same as the resin film used for the first inner layer film, or may be different from the resin film used for the first inner layer film. The specific resin used for the first outer layer film can be the same as that described in the item "(1) inner bag (a) inner layer film (ii) second inner layer film", and therefore is omitted here. Description.

The thickness of the first outer layer film is not particularly limited as long as it can be thermally welded to the second inner layer film, and can be appropriately selected according to the use of the packaging bag of the second embodiment or the like. The thickness of the first outer layer film is, for example, in the range of 10 μm to 100 μm, preferably in the range of 10 μm to 90 μm, and particularly preferably in the range of 15 μm to 80 μm. This is because if the thickness of the first outer layer film is too small, it may become difficult to sufficiently thermally weld the second inner layer film. Moreover, the reason is that it may become difficult to form a good film shape by laminating the second outer layer film. Moreover, when the thickness of the first outer layer film is too thick, it becomes difficult to heat the multilayer structure in the production of the packaging bag of the second embodiment. Since it is transmitted in the thickness direction, it may become difficult to thermally weld the first outer layer film and the second inner layer film, or it may become difficult to thermally weld the first inner layer films to each other. Moreover, the reason is that there is a possibility that the time required for heat fusion is large.

(ii) second outer membrane

In the second embodiment, the second outer layer film is disposed on the outer side of the bag body and includes a film of a resin having a melting point equal to or higher than the melting point of the fluorine-containing resin. Further, the second outer layer film is disposed on the outer side of the bag body. The second outer layer film in the second embodiment has a function of imparting a predetermined strength to the outer bag. The second outer layer film may be the same as that described in the item "I. First Embodiment" described above, and thus the description herein will be omitted.

(iii) Functional layer for outer film

In the second embodiment, the outer layer film may be formed between the first outer layer film and the second outer layer film as needed. The functional layer for the outer layer film can be the same as that described in the section of the functional layer for the outer layer film in the above-mentioned "I. First Embodiment", and thus the description thereof will be omitted.

(iv) outer film

In the second embodiment, the outer layer film is a laminated film of the first outer layer film and the second outer layer film. The thickness of the outer layer film is not particularly limited as long as it can impart a predetermined strength to the outer bag, and can be appropriately selected according to the use of the packaging bag of the second embodiment or the like. The thickness of the outer layer film is, for example, in the range of 20 μm to 120 μm, preferably in the range of 20 μm to 100 μm, and more preferably in the range of 30 μm to 80 μm. The reason is: In the case where the thickness of the outer layer film is too thin, or when it is too thick, the problems described in the item "I. First embodiment" described above may occur.

The method for forming the outer layer film is not particularly limited as long as the first outer layer film and the second outer layer film are laminated to form an outer layer film. The method for forming the specific outer layer film can be the same as that described in the section "(1) inner bag (a) inner layer film (iii) inner layer film".

(b) outer bag

In the second embodiment, the outer bag is disposed on the outer side of the inner bag, and protects the inner bag from impact, friction, and the like from the outside of the package of the second embodiment. In the outer bag, a first outer layer film is disposed on the inner bag side, and a second outer layer film is disposed on the outer side of the bag body.

The form of the outer bag is appropriately determined depending on the form of the packaging bag of the second embodiment. In the second embodiment, it is preferable to arrange the outer bag so as to cover the inner bag. The reason for this is that the inner bag can be preferably protected.

(3) Intermediate bag

Preferably, the packaging bag according to the second embodiment has the bag body further comprising an intermediate bag which is disposed between the inner bag and the outer bag and is formed of an intermediate film, and the multilayer structure of the heat sealing portion has the inner layer overlapping A structure obtained by forming a film, the intermediate film, and the outer layer film, wherein the intermediate film contains a resin which can be thermally welded at a temperature equal to or lower than a melting point of the fluorine-containing resin. In the second embodiment, the strength of the package can be made higher by having an intermediate bag.

The resin used for the interlayer film is not particularly limited as long as it is a resin which can be thermally welded at a temperature equal to or lower than the melting point of the fluorine-containing resin. The resin described in the item "(1) inner bag (a) inner layer film (ii) second inner layer film" is selected and used, and thus the description thereof is omitted. In addition, the thickness of the interlayer film can be set to be the same as the thickness of the inner layer film described in the section "(1) Inner bag (a) inner layer film (iii) inner layer film", and therefore the description is omitted here. Description.

The intermediate film may also have a functional layer for the intermediate film, for example. The innermost layer on the inner bag side of the intermediate film is made of a resin which can be thermally welded to the second inner layer, and the outermost side of the outer bag side is made of a resin which can be thermally welded to the first outer layer. The number of the functional layers of the intermediate film, the layer structure of the intermediate film, and the number of the intermediate pockets may be the same as those described in the above-mentioned "I. First Embodiment", and thus the description thereof will be omitted.

(3) Thermal fusion joint and bag body

The heat-sealed portion and the bag body can be the same as those described in the above-mentioned "I. First embodiment", and thus the description thereof will be omitted.

2. Injection of components and other components

The ejection member in the second embodiment is joined to the bag body described above. The injection member and other configurations can be the same as those described in the item "I. First embodiment" described above, and thus the description thereof will be omitted.

3. Bag

The method for producing the packaging bag according to the second embodiment is not particularly limited, and can be the same as the method for producing a normal packaging bag. Specifically, it can be the same as the manufacturing method of the packaging bag described in the above "I. First embodiment". In the second embodiment, it is preferable to wash the first inner layer side of the inner layer film before the formation of the heat fusion portion. its The reason is that the particles and the like adhering to the liquid medicine side of the inner bag in the second embodiment can be reduced, and the first inner layer film after washing can be easily dried.

III. Third embodiment

According to a third aspect of the invention, the inner layer film includes a first inner layer film disposed on the chemical liquid side, a second inner layer film disposed on the outer bag side, and the inner layer film. In the laminated film of the functional layer for the inner layer film between the first inner layer film and the second inner layer film, the first inner layer film and the second inner layer film contain fluorine having a melting point of 230 ° C or lower. In the film of the resin, the film for thermal fusion in the outer layer film is a film containing a fluorine-containing resin having a melting point of 230 ° C or lower.

According to the third embodiment, the first inner layer film is a fluorine-containing resin film, and elution of impurities into the chemical liquid can be suppressed. Further, the second inner layer film and the first outer layer film are fluororesin films having a predetermined melting point or lower, and the inner layer film and the outer layer film can be thermally welded at a relatively low temperature.

The thickness of the first inner layer film, the inner layer film functional layer, and the second inner layer film can be appropriately selected depending on the use of the packaging bag. The combination of the first inner layer film, the inner layer film functional layer, and the second inner layer film used in the third embodiment (resin of the first inner layer film/functional layer of the inner layer film) Examples of the resin of the second inner layer film include EFEP/polyimine (PI)/EFEP, LM-ETFE/PI/LM-ETFE, and the like. The functional layer for the inner layer film can be set to be the same as that described in the item "II. Second embodiment" described above. In addition, the aspect other than the above may be the same as the packaging bag of the above-mentioned "I. First embodiment".

B. Container for liquid medicine storage

The container for medicinal liquid storage of the present invention includes the outer container and the packaging bag for medicinal liquid disposed in the outer container, wherein the medicinal liquid storage bag is the above-mentioned "A. medicinal liquid storage bag. The packaging bag for liquid medicine storage described in the item.

In other words, the chemical storage container according to the present invention includes an outer container and a chemical liquid storage package disposed in the outer container, wherein the medical liquid storage package has a bag body having a inside. An inner bag which is formed of a layer film and houses the chemical liquid, and a bag which is formed of an outer layer film and disposed outside the inner bag; and the injection member is joined to the bag body, and the inner bag and the outer bag have overlapping The multilayer film and the outer layer film have a multilayer structure in which a heat-welded portion is welded in a state in which the inner layer films are opposed to each other, and the inner layer film has a melting point of 230 on the outermost surface of the chemical liquid side. a film of a fluorine-containing resin having a temperature of ° C or less, wherein the outer layer film has a first outer layer film disposed on the inner bag side and a laminated film disposed on a second outer layer film disposed on an outer side of the bag body, wherein the first outer layer film A film for heat fusion which is thermally fused to the inner layer film, and the second outer layer film includes a film having a resin having a melting point equal to or higher than a melting point of the fluorine-containing resin of the inner layer film.

16 and 17 are schematic cross-sectional views showing an example of another container for storing a chemical liquid according to the present invention and another example. As shown in FIG. 16 and FIG. 17, the chemical liquid storage container 4 includes an outer container 5 and a chemical liquid storage packaging bag 1 disposed in the outer container 5. Fig. 15 shows an example of a packaging bag for storing a chemical liquid according to the first embodiment, and Fig. 16 shows an example of a packaging bag for a chemical liquid according to the second embodiment. The packaging bag 1 for the chemical liquid storage can be the same as that described with reference to FIGS. 1 to 3 and FIGS. 13 to 15 , and thus the description thereof will be omitted. In addition, FIG. 16 and FIG. 17 show an example in which the outer container 5 is a metal can, and the gas supply unit 52 including the container main body 51, the supply of nitrogen gas to the container main body 51, and the injection of the chemical liquid storage packaging bag 1 are shown. Out An example in which the member 3 is fixed to the fixing portion 53 of the container body 51.

According to the present invention, it is possible to provide a drug solution storage container which can prevent the impurities in the inner bag in the drug solution storage bag from being eluted into the chemical solution and can accommodate the drug solution. Hereinafter, the details of the drug storage container of the present invention will be described.

1. Medicine liquid storage bag

The pharmaceutical liquid packaging bag according to the present invention is disposed in the outer container. The details of the packaging bag for medicinal liquid storage according to the present invention can be the same as those described in the section "A. Packaging bag for medicinal liquid storage", and therefore the description thereof will be omitted.

2. Outside container

In the present invention, the outer container is disposed on the inner side of the package for storing the chemical liquid. The outer container usually has a container body for arranging the drug solution storage bag and holding the drug solution, and a fixing portion for fixing the injection member in the drug solution storage bag. Moreover, as the outer container, as shown in FIG. 16, a gas supply unit 52 that supplies nitrogen gas or the like to the inside of the container body 51 may be provided.

The outer container may be the same as the user of the usual chemical liquid storage container, and examples thereof include an outer container such as a metal, a synthetic resin, or a paper. More specifically, examples of the outer container include a metal can, a polyethylene bottle, and a case of corrugated cardboard.

3. Container for liquid medicine storage

The container for storing a chemical solution according to the present invention includes the outer container and the chemical liquid. The packaging bag is not particularly limited, and other configurations may be appropriately selected and added as needed.

Further, in the drug storage container of the present invention, when the drug solution filled in the drug solution bag is taken out, the drug solution can be taken out by applying pressure from the outside of the drug solution bag. FIG. 18 is an explanatory view for explaining a method (an injection method) for taking out a chemical solution in the container for storing a chemical solution according to the present invention. In the method of dispensing the chemical liquid L in the chemical storage container 4 of the present invention, the nozzle 61 is used to supply the nitrogen gas G from the gas supply unit 52 to the inside of the container body 51. Pressure is applied to the outside of the chemical storage bag 1 by the nitrogen gas G supplied to the inside of the container body 51. By the pressure, the chemical liquid L filled in the chemical storage bag 1 is pushed out to the outside of the chemical storage bag 1 through the nozzle 62, and the chemical liquid L is taken out. Incidentally, the symbols that are not described in FIG. 18 may be the same as those described in FIG. 16 and the like, and thus the description thereof will be omitted.

Furthermore, the present invention is not limited to the above embodiment. The above-described embodiments are exemplified, and those having substantially the same configuration as the technical concept described in the patent application of the present invention and having the same effects are included in the technical scope of the present invention.

[Examples]

Hereinafter, the details of the packaging bag of the present invention will be described by way of examples and comparative examples.

[Example 1] <Thermal fusion test of fluorine-containing resin film>

A laminate film composed of LM-ETFE, PE, and PBT, each of which is a functional layer of the first outer layer film and the outer layer film, and a second outer layer film, is used as an outer layer film. Also, use LM-ETFE As an inner layer film. The multiple structures of the outer layer film and the inner layer film are superimposed so that the inner layer film side faces each other, and the sheet is placed at 230 ° C for 10 seconds, the welding pressure is 0.1 MPa, and the number of welding times is twice. Thermal fusion, whereby a double bag can be formed. Further, the adhesion strength of the heat-sealed portion of the double bag was measured under the above conditions using a tensile tester, and as a result, it was confirmed that there was a bonding strength of 25 N/15 mm or more.

[Embodiment 2]

A laminate film composed of PE and PBT, respectively, of the first outer layer film and the second outer layer film was used as the outer layer film. Further, an interlayer film composed of LM-ETFE and PE, respectively, of the first inner layer film and the second inner layer film was used as the inner layer film. The multilayer structure in which the above-mentioned outer layer film and the inner layer film are superposed is disposed such that the inner layer film side faces each other, and is carried out at 230 ° C under conditions of a welding time of 10 seconds, a welding pressure of 0.1 MPa, and a number of welding times of two times. Thermal fusion, whereby a double bag can be formed. Further, the adhesion strength of the heat-sealed portion of the double bag was measured under the above conditions using a tensile tester, and as a result, it was confirmed that there was a bonding strength of 25 N/15 mm or more.

[Comparative example]

PTFE, PFA, FEP, and ETFE cannot form a laminate film with other resins, and are difficult to use as an inner layer film.

[Reference Example 1] <Dissolution test of impurities of fluorine-containing resin film>

Various fluororesin films cut out from PTFE (thickness 100 μm), PFA (thickness 50 μm), FEP (thickness 50 μm), ETFE (thickness 50 μm), LM-ETFE (thickness 25 μm) 25 9 sheets of a film having a size of mm × 100 mm were immersed in 13 mL of dimethyl carbonate (DMC) as a solvent for an electrolyte solution for a lithium ion battery, and allowed to stand at 60 ° C for one week. Then, it was confirmed whether the component derived from the fluororesin film was eluted from the film to the solvent by using a gas chromatography mass spectrometer (manufactured by Shimadzu Corporation, product name: GCMS-QP2010). The conditions are the same as Reference Example 3 described below. In any of the fluororesin films, the peak of the component derived from the fluororesin was not detected based on the chromatogram obtained by gas chromatography mass spectrometry.

[Reference Example 2] <Thermal fusion test of fluorine-containing resin film>

Two sheets of each of the fluororesin films (PTFE, PFA, FEP, ETFE, PCTFE, and LM-ETFE) were heat-sealed at 230 ° C in a state of being overlapped to confirm the presence or absence of heat fusion. PTFE, PFA, FEP, and ETFE were not thermally welded under the conditions of 10 seconds of welding time, 0.1 MPa welding pressure, and 2 times of welding, but PCTFE and LM-ETFE were heat-sealed. The adhesion strength of the film of PCTFE and LM-ETFE under the above conditions was measured by a tensile tester, and it was 25 N/15 mm or more.

[Reference Example 3] <Resin Dissolution Test of Resin Film>

The dissolution test of the impurities was carried out for the samples described below. A PTFE film (thickness: 100 μm) was used as the sample 1, and an LM-ETFE film (thickness: 50 μm) was used as the sample 2. As a sample 3, a laminate in which a two-layer laminated film of LM-ETFE and ultra-low-dissolved PE (thickness: 100 μm) was thermally welded to each other at an ultra-low elution PE surface was used. As the sample 4, an ultra-low-dissolved PE film (thickness: 80 μm) was used, and a usual PE film (thickness: 50 μm) was used as the sample 5. again As an ultra-low-dissolving PE film, a non-added NOVATEC LD (Japan Polyethylene Co., Ltd.) is used to inflate a film into a film. As a normal PE film, Umerit125FN (UBE-MARUZEN POLYETHYLENE Co., Ltd.) which is not added is used. ) Inflated into a film.

For the samples 1, 2, 4, and 5 described above, a plurality of strips were sampled so as to have a total volume of 600 mm ³ , and immersed in 4 mL of dimethyl carbonate (DMC) and allowed to stand at 60 ° C for 1 week. Further, in the sample 3, a plurality of strips were sampled so as to have a total volume of 400 mm ³ , and immersed in 4 mL of dimethyl carbonate (DMC) and allowed to stand at 60 ° C for one week. Further, similarly, for the samples 1, 2, 4, and 5, a plurality of strips were sampled so as to have a total volume of 600 mm ³ , and for the sample 3, a plurality of strips were sampled so as to have a total volume of 400 mm ³ . The mixture was immersed in 4 mL of propylene glycol-1-monomethyl ether acetate (PGMEA) and allowed to stand at 60 ° C for 1 week to prepare an eluate from each sample.

Thereafter, each solution was analyzed using a gas chromatography mass spectrometer (manufactured by Shimadzu Corporation, product name: GCMS-QP2010). In the measurement by gas chromatography, 1 μL of the eluate was introduced into a gasification chamber. The heating conditions of the gasification chamber were set to 300 °C. The column used was a column with a length of 30 m, an inner diameter of 0.25 mm, and a stationary phase (corresponding to dimethyl methoxyoxane 95% phenyl 5%) of 0.25. The temperature rise condition of the column oven was maintained at 50 ° C for 5 minutes, and then the temperature was raised to 320 ° C at 10 ° C / min, and held at 320 ° C for 8 minutes to carry out measurement. The results are shown in Table 1, Figure 19, and Figure 20. Table 1 is a table showing the peak intensities of alkanes (olefins) detected near the dissolution time of 15.88 min. 19 and 20 show the results of gas chromatography mass spectrometry. In Table 1, FIG. 19, and FIG. 20, the sample 3 is represented by a converted value converted into a total volume of 600 mm ³ and represents a value in the case where the total volume of each sample is the same.

[Table 1]

As shown in Table 1, FIG. 19, and FIG. 20, in any of DMC and PGMEA, no peak of impurities was observed in both Sample 1 and Sample 2. On the other hand, regarding the samples 3 and 4, the peak of the alkane (olefin) was confirmed at the elution time of 15.88 min. Therefore, the amount of elution as an impurity is considered to be a relationship of PTFE ≒ LM-ETFE < LM-ETFE / ultra-low-dissolved PE < ultra-low-dissolved PE < (normally PE). Further, regarding the sample 3, although some dissolution was observed, the detection intensity was lower than that of the sample 4. The reason is presumed to be that the LM-ETFE of the sample 3 on the surface side inhibits the elution of the sample 3 from the PE of the host. From this result, it was confirmed that the elution of impurities from the low-melting PE film located inside the laminated film at the inside was suppressed. In other words, when the laminated film was used for the inner bag, it was confirmed that elution of impurities can be suppressed as compared with the case where the ultra-low elution film is used for the inner bag. Moreover, when only the LM-ETFE film was used for the inner bag, it was confirmed that the elution of impurities can be more effectively suppressed.

1‧‧‧Packing bag for medicine liquid storage (packaging bag)

2‧‧‧ bag body

3‧‧‧Note components

21‧‧‧ inner pocket

21a‧‧‧ Inner film

22‧‧‧ outer bag

22a‧‧‧ outer film

23‧‧‧Hot welding joint

221‧‧‧1st outer membrane

222‧‧‧2nd outer membrane

Claims (6)

A pharmaceutical liquid packaging bag comprising: an inner bag including an inner layer film and containing a chemical liquid; and a bag body including an outer layer film and disposed outside the outer bag, and the bag a body-joining injection member; wherein the inner bag and the outer bag have a heat-welding portion, and the plurality of layers formed by overlapping the inner layer film and the outer layer film are configured such that the inner layer films overlap each other And the inner layer film has a film containing a fluorine-containing resin having a melting point of 230 ° C or less on the outermost surface of the chemical liquid side, and the outer layer film has a first outer layer film disposed on the inner bag side, And a laminated film of the second outer layer film disposed on the outer side of the bag body, wherein the first outer layer film is a film for thermal fusion bonding that is thermally fused to the inner layer film, and the second outer layer film includes the inner layer A film of a resin having a melting point equal to or higher than a melting point of the above-mentioned fluorine-containing resin of the film. The packaging medium for a chemical solution according to claim 1, wherein the inner layer film contains only the film containing the fluorine-containing resin, and the film for thermal fusion in the first outer layer film contains fluorine having a melting point of 230 ° C or lower. A film of resin. The packaging bag for a chemical solution according to claim 2, wherein the bag body further includes an intermediate bag which is disposed between the inner bag and the outer bag and is formed of an intermediate film, and the multilayer structure of the heat-sealed portion has a structure in which the inner layer film, the intermediate film, and the outer layer film are overlapped, The intermediate film has a film containing a fluorine-containing resin having a melting point of 230 ° C or less. The package for storing a chemical solution according to claim 1, wherein the inner layer film is a first inner layer film having a fluorine-containing resin having a melting point of 230 ° C or less disposed on the chemical liquid side, and is disposed in the outer bag. a laminated film comprising a second inner layer film of a resin thermally splicable at a temperature equal to or lower than a melting point of the fluorine-containing resin, wherein the heat-fusible film in the outer layer film is included A film of a resin which is thermally welded at a temperature equal to or lower than the melting point of the fluorine-containing resin. The packaging bag for a chemical solution according to claim 4, wherein the bag body further includes an intermediate bag which is disposed between the inner bag and the outer bag and is formed of an intermediate film, and the multilayer structure of the heat-sealed portion has The inner layer film, the intermediate film, and the outer layer film are laminated, and the intermediate film is a film containing a resin which can be thermally welded at a temperature equal to or lower than a melting point of the fluorine-containing resin. A container for storing a chemical liquid, comprising: an outer container; and a packaging bag for storing a chemical liquid disposed in the outer container; wherein the drug storage bag has a bag body having an inner layer An inner bag of the chemical liquid and a bag formed of the outer layer film and disposed outside the inner bag; and a dispensing member joined to the bag body; the inner bag and the outer bag having a heat fusion portion The multilayer structure in which the inner layer film and the outer layer film are superposed is welded in a state in which the inner layer films are opposed to each other, and the inner layer film has a melting point on the outermost surface of the chemical liquid side. In the film of the fluorine-containing resin of 230 ° C or lower, the outer layer film is a laminated film having a first outer layer film disposed on the inner bag side and a second outer layer film disposed on the outer side of the bag body. The first outer layer film is a film for heat fusion which is thermally fused to the inner layer film, and the second outer layer film is a resin containing a melting point equal to or higher than a melting point of the fluorine-containing resin of the inner layer film. membrane.