TW201504380A - Water-bone pressure sensitive adhesive composition and its application in hydrophilic drug delivery patch - Google Patents

Abstract

The present invention relates to a water-bone pressure sensitive adhesive composition, which comprises a polymer co-polymerized by (methyl) acrylic acid and its ester monomers, poly(ethylene oxide) or poly(propylene oxide) or their copolymers, and optionally a polyacrylic acid and polysaccharides (such as natto extract or chitosan). With the present invention, the drug sticker cloth (film) made of water-bone pressure sensitive adhesive composition has strong adhesion force, covering a long time of sticking to the skin without causing skin allergies, also can produce a long time and sustained effect of transdermal drug delivery on the surface of the skin.

Description

Water-based pressure-sensitive adhesive composition and application thereof to water-based adhesive tape

The present invention relates to a water-based pressure-sensitive adhesive composition. The invention and its application, a water-based pressure-sensitive adhesive patch (film) containing the water-based pressure-sensitive adhesive composition.

At present, the pressure sensitive adhesive tape (film) on the market, most of the pressure sensitive adhesive used is an oily pressure adhesive. Although many pressure-sensitive adhesives used in pressure-sensitive adhesive tapes (films) are water-soluble before coating, they are actually oily pressure-sensitive adhesives emulsified in water, once coated. After drying, it returns to oiliness, is no longer soluble in water, and does not absorb moisture.

If the pressure-sensitive adhesive patch (film) is adhered to the skin of the human body, it is easy because the oily adhesive does not absorb the moisture discharged from the skin, causing poor sweat perspiration and affecting the metabolism function of the sweat glands of the skin. The pores of the skin at the patch are blocked. Although it is not easy to fall off when it is pasted, it may cause rash, flushing, itching and other discomforts in the skin of the adhesive site. This is the uncomfortable feeling of allergies.

Water-based drug tape is the development trend of a new type of medical patch, it The main disadvantages that have overcome the traditional oily adhesive patch are as follows:

1. After a long time, the skin will be gas-impermeable and allergic, causing skin irritation and other skin allergies.

2. The use of organic solvents in the manufacturing of raw materials can cause excessive environmental pollution.

3. Waste of solvent and petroleum resources, contrary to the trend of world energy conservation and carbon reduction.

At present, there is indeed a market for the development of such water-sensitive adhesive tapes, especially water-based adhesive tapes. However, these water-based adhesive tapes are insufficient for the adhesion strength of the surface of the adherend skin. Can not be applied to the skin of the adherend for a long time. In particular, when the patch-adhered skin is a joint between the neck, the elbow, the knee, and the like, the patch is more likely to fall off quickly and cannot be used.

In order to solve the shortcomings of the insufficient adhesion strength of the skin surface, the water-based adhesive tape on the market currently needs to use an oil-based auxiliary adhesive. In this way, in manufacturing, the cost of an oil-based auxiliary adhesive is increased, and the solvent resources are wasted and not environmentally friendly. In addition to use, in addition to very inconvenient. Also, because there is still a part of the applied skin that must be applied with the oily adhesive, the use of the skin is still uncomfortable. The overall product still has the defect that the oily adhesive tape is uncomfortable to the body. In addition, although the aqueous adhesive tape can utilize the surrounding oil-based auxiliary adhesive to enhance the effect of fixing on the skin, whether the drug-containing aqueous adhesive patch portion is completely conformed to the skin, and still Doubt, if not completely fit, the drug cannot be transported into the skin at all, thus affecting the efficiency of transdermal drug delivery.

In order to improve the shortcomings of the adhesiveness of the general water-based adhesive tape, it is necessary to use an oil-based auxiliary adhesive which has a larger area than the aqueous adhesive tape. Although it can improve the lack of adhesion. But its shortcomings are:

1. Will still increase the waste of materials.

2. Contact with the skin of the oily patch area is still susceptible to sensitivity.

3. It is not convenient to use the sticker program.

Although several patented methods for improving their inconvenience have been proposed, they still have the above disadvantages of 1. and 2.

These patents include, Taiwan Patent Publication No. 376847 discloses the addition of a waterproof film in the central area of the hydrophobic adhesive bandage, so that when it is manufactured, it begins to adhere to the aqueous drug tape for a long time, and the remaining oily adhesive which is not adhered to the drug tape. The glue area is applied directly to the skin around the affected area when in use. The design is that the water-based medicinal adhesive tape and the oil-based auxiliary adhesive are first bonded together, and the two-piece adhesive tape of the product is integrally packaged. In this way, it is possible to dispense with the troublesome combination procedure of applying the aqueous medicinal tape and the oil-based auxiliary adhesive at the same time.

However, the product design concept of this patented method is to reduce the inconvenience in use by first attaching two pieces of oil-based auxiliary adhesive and water-based adhesive tape to a two-layer product. It is also possible to strengthen the water-based adhesive patch which can be fixed to the skin or the joints of the body for a long time, and the like, so that it can be fixedly attached for a long time without falling off. However, some parts of the applied skin must still be covered with the oily adhesive, and the use of the process may cause the skin allergy discomfort. The overall product still has the defect that the oily adhesive tape causes discomfort to the body. In addition, although the water-based adhesive patch can utilize the surrounding oil-assisted back The glue improves the effect of fixing on the skin. However, whether the part of the drug-containing aqueous gel patch is completely conformed to the skin, there are still doubts, and if it is not completely adhered, the drug cannot be transported at all.

Taiwan Patent Publication No. 516438 (Dongfa), the patent design is also an integrated product, which simplifies the packaging of the product, and also eliminates the need for the user to adhere the aqueous drug tape to the combination of the hydraulic adhesive bandage. However, the focus is on the addition of oil-based adhesive areas of different geometries on both sides of the water-based adhesive tape. This design can also increase the firmness of the patch to the skin. The design can also reduce the skin contact with the oily adhesive area, and hope to reduce the metabolism function of the skin sweat gland and reduce the discomfort caused by the skin, such as rash, flushing and itching. However, the whole group of products still need to use the oil-based auxiliary adhesive to fix the water-based adhesive tape for a long time to the skin, or to make the joints of the body joints and other places that are not easy to be attached for a long time to be fixed and not peeled off.

Although these patents overcome the main disadvantages of the above-mentioned inconvenience in the use of the oily rubber patch and the water-based patch, it is convenient to use. However, it still exists because the water-based adhesive patch is not strong enough for the skin to be applied, and the oil-based auxiliary adhesive must be used to strengthen the adhesiveness of the water-based patch to the skin and prevent the patch from falling off.

In order to solve the problems of the prior art as described above, it is an object of the present invention to provide an improved water-elastic pressure-sensitive adhesive composition which has strong adhesion to human skin and provides skin comfort.

The present invention provides a water-based pressure-sensitive adhesive composition comprising: a) a (meth)acrylic copolymer; and b) poly(ethylene oxide), poly(propylene oxide) or a copolymer thereof .

The water-based pressure-sensitive adhesive composition of the present invention may further comprise c) a polysaccharide such as natto extract or chitosan, or polyacrylic acid for adjusting viscosity.

The water-small pressure-sensitive adhesive composition of the present invention may further comprise a pH adjusting agent, and suitable pH adjusting agents include, but are not limited to, alcohol amine compounds such as ethanolamine, diethanolamine, triethanolamine and the like.

For example, the water-based pressure-sensitive adhesive composition of the present invention can be applied to an aqueous gelatin patch, which can improve the adhesiveness of the existing water-based adhesive patch to the skin, and when it is applied to the skin, the following Features:

1. Applying the pressure-sensitive adhesive patch (sheet, film) or the underwear of the female underwear prepared by using the water-pressure adhesive composition of the present invention, when applied to the surface of the skin, it can be produced for a long time and continuous Strong adhesion effect. Moreover, it does not cause skin rash, flushing, itching and the like.

2. In particular, the water-based adhesive tape or the underwear of the female underwear prepared by using the water-pressure adhesive composition of the present invention has a strong covering force to the skin when applied to the skin surface, and It is applied to the skin for a long time and is not easy to fall off.

3. Applying the water-based adhesive tape made of the water-based pressure-adhesive composition of the present invention, when applied to the skin surface, the oil-based auxiliary adhesive can be dispensed with, and the area covered with the skin is all the aqueous glue area. , completely oil-free sexy Pressure adhesive area. Therefore, it is applied to the skin for a long time without causing allergies such as itching.

The aqueous gelatin patch made by using the water-pressure adhesive composition of the present invention can be applied to the skin for a long time, so that the drug can be released through the skin for a long time and continuously through the skin. Delivery), allowing the skin surface to effectively absorb the drug. Unlike the existing commercially available water-based adhesive tapes, when the oil-based auxiliary adhesive is used, the middle aqueous adhesive patch area will temporarily be detached from the skin, thus making the drug unsustainable for a long time and slow release through the skin. To make the skin surface absorb drugs with limited effect.

11‧‧‧Kebu layer

12‧‧‧Water-based syrup

13‧‧‧Skin adhesion zone

14‧‧‧away paper

Fig. 1 shows the results of transdermal delivery of a drug of product F (Kefina sodium salt) of Example 1 of the present invention at 1-8 hours, wherein the horizontal axis is wavelength (nm) and the x-axis is absorption.

Fig. 2 is a graph showing the comparison of peeling strength data between the product F and the commercially available products A, B, and G in the first embodiment of the present invention.

Fig. 3 is a comparison chart of the retention test data of the product F of Example 1 of the present invention and 500 g of the commercially available product G.

Figure 4 is a graph showing the retention test data for 250g of commercially available products A and B.

Figure 5 is a schematic perspective view showing the product F of the first embodiment of the present invention being made into an aqueous drug-containing patch.

Figure 6 is a schematic cross-sectional view of the aqueous drug-containing patch of Figure 5.

The invention utilizes a hydrophilic monomer to copolymerize in water. In addition to adding a soft segment having a soft segment, a polysaccharide such as natto extract or chitosan or polyacrylic acid may be added to the copolymerization reaction. Further, a pH adjusting agent may be further added after completion to prepare the water-based pressure-sensitive adhesive of the present invention. The water-based pressure-sensitive adhesive prepared by the invention, wherein the copolymer and the added polyether, or the natto extract or chitosan, or polyacrylic acid, can generate a large amount of intramolecular and intermolecular hydrogen bonds, Or a secondary bonding force such as Van Valli to produce a water-based pressure-sensitive adhesive having enhanced external adhesion and internal cohesion, and also imparts the water-based pressure-sensitive adhesive of the present invention to the adhesive. Skin comfort after skin.

The term "(meth)" before "acrylic acid" in the present specification means that the methyl group may be present and absent, for example, poly(meth)acrylic acid represents polyacrylic acid and polymethacrylic acid.

Preferred aspects of the invention include, but are not limited to:

A water-squeezing pressure-sensitive adhesive composition comprising a copolymer of a) a (meth)acrylic monomer, and b) an oxygen-extended ethyl or an oxygen-extended propyl or a re-unit of 2 to 150 An ether oligomer of a poly(ethylene oxide), poly(propylene oxide) or (ethylene oxide)/(propylene oxide) copolymer, wherein the weight ratio of the component a) to b) is 99 : 1 to 50:50.

2. The composition of claim 1, which further comprises a polysaccharide body, wherein the polysaccharide is present in an amount of from 0.01 to 15% based on the weight of the components a) and b).

3. The composition of claim 2, wherein the polysaccharide is natto Extract or chitosan.

4. The composition of claim 1, which further comprises polyacrylic acid, wherein the polyacrylic acid is present in an amount of from 0.01 to 15% based on the weight of the components a) and b).

5. The composition of claim 2, further comprising polyacrylic acid, wherein the polyacrylic acid is present in an amount of from 0.01 to 15% based on the weight of the components a) and b).

6. The composition of claim 3, further comprising polyacrylic acid, wherein the polyacrylic acid is present in an amount of from 0.01 to 15% based on the weight of the components a) and b).

7. The composition according to any one of aspects 1 to 6, wherein the component a) is a monomer comprising 1-20% of (meth)acrylic acid or (meth)acrylic acid alkyl (meth)acrylate and 80%-99 a copolymer of a mixture of hydroxyl group-containing (meth)acrylic acid alkyl (meth) acrylates, based on the weights of components a) and b), wherein the ether group of b) has from 2 to 150 units a poly(ethylene oxide), poly(propylene oxide) or (ethylene oxide)/(propylene oxide) copolymer of a repeating unit of an oxygen-extended ethyl or oxygen-extended propyl group or a mixture of the two. Formed by ether oligomer diols.

8. The composition of claim 7, wherein the hydroxyl group-containing (meth)acrylic acid alkyl (meth) acrylate is hydroxyalkyl acrylate, hydroxyalkyl (meth) acrylate, ω-hydroxy polyether acrylate Or ω-hydroxy polyether ester of (meth)acrylic acid.

9. The composition of claim 8, wherein the above-mentioned hydroxyl group-containing (meth)acrylic acid alkyl (ether) ester is 2-hydroxyethyl acrylate, 2-hydroxyethyl (meth)acrylate, glyceryl acrylate, (A) Glyceryl acrylate, Pentaeryth ret yl acrylate, Pentaeryth ret yl (meth) acrylate, ω-hydroxydiethylene glycol ether acrylate ( ω-Hydroxyl diethyleneglycolyl acrylate, ω-Hydroxyl diethyleneglycolyl (meth)acrylate, ω-Hydroxyl polyethyleneglycolyl acrylate, Or omega-hydroxyl poly(ethylene glycol acrylate) (ω-Hydroxyl polyethyleneglycolyl (meth)acrylate).

10. The composition of claim 7, wherein the alkyl (meth)acrylate monomer in the (meth)acrylic acid or alkylene (meth)acrylate monomer is butyl acrylate, Butyl (meth) acrylate, 2-ethylhexyl acrylate, 2-ethylhexyl (meth) acrylate.

11. The composition of claim 7, wherein the (meth)acrylic acid ether ester monomer in the (meth)acrylic acid or (meth)acrylic acid alkylene ether (meth)acrylate monomer is an ether acrylate, (meth)acrylic acid Ether ester, di- acrylate ether, bis-(meth) acrylate ether, wherein the ether group is a repeating unit having 2 to 150 units of an oxygen-extended ethyl group or an oxygen-extended propyl group or a mixture of the two An ether oligomer diol formed of a poly(ethylene oxide), poly(propylene oxide) or (ethylene oxide) / (propylene oxide) copolymer.

12. The composition of claim 11, wherein the (meth) acrylate ether ester monomer is ω-Methyl diethyleneglycolyl acrylate, (meth)acrylic acid ω-methyl acrylate ω-Methyl diethyleneglycolyl (meth)acrylate, ω-Methyl polyethyleneglycolyl acrylate Acrylate), ω-Methyl polyethyleneglycolyl (meth)acrylate, Ethyleneglycolyl diacrylate, di-(meth)acrylic acid Ethyleneglycolyl di(meth)acrylate, Diethyleneglycolyl diacrylate, Diethyleneglycolyl di(meth)acrylate, Di-acrylic acid Poylethyleneglycolyl diacrylate, or Poylethyleneglycolyl di(meth)acrylate.

13. The composition of any of aspects 1 to 6, further comprising 1-10% of a pH adjusting agent based on the weights of components a) and b).

14. The composition of claim 13, wherein the pH adjusting agent is an alcohol amine compound.

15. The composition of claim 14, wherein the alcohol amine compound is ethanolamine, diethanolamine or triethanolamine.

An aqueous medicated tape comprising a base fabric layer and a water squeezing adhesive composition according to any one of aspects 1 to 15 coated on a surface of the base fabric layer.

The water-based pressure-sensitive adhesive composition of the present invention may further comprise a plasticizer, an antioxidant, a UV stabilizer, a filler, an antifoaming agent, a neutralizing agent, a rocking agent, a tackifier, and an interfacial activity according to the purpose. It is made up of a drug and a drug release accelerator.

Example Preparation Example 1.

40 parts by weight of 2-hydroxyethyl methacrylate (2-HEMA), 30 parts by weight of ω-Hydroxyl triethyleneglycolyl (ω-Hydroxyl triethyleneglycolyl) Meth)acrylate, TEMA), 10 parts by weight of an acrylic monomer of 2,3-Dihydroxypropyl (meth)acrylate (DHPA), and 10 parts by weight of a polyethylene glycol ether (PEG) , MW = 5000), 1.7 parts by weight of acrylic acid (AA), 1.3 parts by weight of natto extract mixture (NDE) (this extract mixture, the natto fermented product is diluted 3 times with water, and the natto particles are filtered off. The obtained aqueous solution is further concentrated back to the original concentration), 7 parts by weight of polyacrylic acid (PAA) is placed in a 1 liter reaction tank system with nitrogen reflux and temperature adjustment, and 120% by weight of deionized water is added thereto. As a solvent. In order to remove the oxygen in the reaction tank, nitrogen gas is continuously supplied into the reaction tank. During this period, the temperature is maintained at 65-95 ° C. After the mixed monomer is uniformly mixed, 0.05 weight percent of potassium persulfate (KPS, potassium) is added. Persulfate) is used as a starting agent for the reaction. The mixture solution is reacted for 2 hours, and then 3 parts by weight of Triethanol amine (TEA) is added to obtain a product having a solid content of 46 parts by weight, that is, the (meth)acrylic aqueous copolymerization of the pressure sensitive adhesive. Things.

Preparation Examples 2 to 4:

As shown in Table 1, the amount of the component used in the above Preparation Example 1 was changed by partial addition or partial reduction to prepare a medium-high molecular weight acrylic copolymer.

Preparation Examples 5 to 7:

As shown in Table 1, the amount of the component used in the above Preparation Example 1 was changed by partial addition or partial reduction to prepare a high molecular weight acrylic copolymer.

Preparation Example 8.

40 parts by weight of 2-hydroxyethyl acrylate (2-HEA), 42 parts by weight of ω-Methyl polyethylene glycol acrylate (PEGA), 5 parts by weight Acrylic monomer of ω-Hydroxyl triethyleneglycolyl acrylate (TEGA), with 10 parts by weight of PEG (MW=4000), 1.8 parts by weight of methacrylic acid (MAA), 0.7 part by weight of Polycarbohydrate (PCH) was placed in a 1 liter reaction tank system with nitrogen reflux and temperature, and 120% by weight of deionized water was added thereto as a solvent. In order to remove the oxygen in the reaction tank, nitrogen gas is continuously supplied into the reaction tank. During this period, the temperature is maintained at 65-95 ° C. After the mixed monomer is uniformly mixed, 0.05 weight percent of potassium persulfate (KPS, potassium) is added. Persulfate) is used as a starting agent for the reaction. The mixture solution was reacted for 2 hours, and 3 parts by weight of ethanolamine (Ethanol amine, EA) was further added to obtain a product having a solid content of 46 parts by weight, that is, the (meth)acrylic aqueous copolymer of the pressure sensitive adhesive. .

Preparation Examples 9 to 11:

As shown in Table 2, the amount of the component used in the above Preparation Example 8 was changed by partial addition or partial reduction to prepare a medium-high molecular weight acrylic copolymer.

Preparation Examples 12 to 14:

As shown in Table 2, the amount of the component used in the above Preparation Example 8 was changed by partial addition or partial reduction to prepare a high molecular weight acrylic copolymer.

Preparation Example 15.

50 parts by weight of 2-HEA, 10 parts by weight of 2-Ethylhexyl acrylate (2-EHA), 30 parts by weight of ω-hydroxypentaethylene glycol (meth)acrylate ( ω-Hydroxyl pentaethyleneglycolyl (meth)acrylate, PEMA) acrylic monomer, with 10 parts by weight of PEG (MW = 4000), 1.8 parts by weight of MAA, placed in a 1 liter reaction tank system with nitrogen reflux and temperature adjustment 120% by weight of deionized water was added thereto as a solvent. In order to remove the oxygen in the reaction tank, nitrogen gas is continuously supplied into the reaction tank. During this period, the temperature is maintained at 65-95 ° C. After the mixed monomer is uniformly mixed, 0.05 weight percent of potassium persulfate (KPS, potassium) is added. Persulfate) is used as a starting agent for the reaction. The mixture solution was reacted for 2 hours to obtain a (meth)acrylic aqueous copolymer having a solid content of 46 parts by weight, that is, the pressure-sensitive adhesive.

Preparations 16 to 18:

As shown in Table 3, the amount of the component used in the above Preparation Example 15 was changed by partial addition or partial reduction to prepare a medium-high molecular weight acrylic copolymer.

Preparations 19 to 21:

As shown in Table 3, the amount of the component used in the above Preparation Example 15 was changed by partial addition or partial reduction to prepare a high molecular weight acrylic copolymer.

Example 1.

75 parts by weight of the above prepared acrylate copolymer (H-1) colloid, 25 parts by weight of deionized water, and 0.05 parts by weight of the drug Diclofenac sodium (to be ketone sodium salt, DFS), etc. . After the finished glue is coated by the machine, it is then partially dried to make it free of charge. The water-based adhesive tape of the oil-based adhesive single-layer water-based adhesive patch (product F, P-2, P-3) is shown in Table 4.

Examples 2 to 3:

The amount of each component used in Example 1 was changed by partial addition or partial reduction to prepare a single-layer aqueous adhesive patch of the oil-free adhesive which was code-named P-2 and P-3. .

The drug release test, the peel strength test, and the hanging ball test were carried out using the single-layer aqueous adhesive tape patch prepared in accordance with Example 1 which was free of oily backing.

A. (drug release analysis)

The drug release test was carried out on the single-layer aqueous adhesive tape (product F) of the oil-free adhesive prepared in Example 1 using the apparatus and conditions listed in Table 5, wherein the drug release amount was measured by ultraviolet light and visible light spectrometry. the amount. The results are shown in Figure 1.

B. Peel strength test

Water-based adhesive glue prepared by using the water-based pressure-sensitive adhesive of the present invention Patch--one-layer water-based adhesive tape (product F), which is free of oily adhesive, and A-B, water-based adhesive tape, commercially available product G, and pressure sensitive adhesive according to ASTM D3330 The peel strength test method (Peel adhesion of pressure-sensitive-adhesive tape at 180° Angle) was subjected to a 180° peel strength test analysis. Attaching to a specific substrate at a fixed pressure, and then peeling the patch from the surface of the substrate at a fixed rate, the patch can be peeled off from the surface of the substrate, and the required peeling force per unit length of the patch (peel force/mm) The larger the value, the tighter the adhesion of the patch to the surface of the substrate. When the patch needs a large peeling force to peel off from the surface of the substrate, the better the adhesion effect is, that is, the Peel strength test. The test analysis data is shown in Figure 2 and Table 7 below.

C. Hanging power test (Holding power test)

The holding power test is the agglutination strength of the medicinal rubber structure, the internal cohesive force of the medicinal rubber is strong, and the residual glue is not easily generated during use, and the water-based medicinal adhesive tape of the present invention is used to produce the water-based medicinal adhesive tape- - A single-layer water-based adhesive patch product (product F) that is free of oily adhesive, and a commercially available water-based adhesive tape A, B, and a commercially available oil-based adhesive tape G according to ASTM D3654 standard test method for shear adhesion of Pressure-sensitive-adhesive tape for retention test analysis, used The instrument and test conditions are listed in Table 8. The data obtained from the analysis are listed in Table IX and Figure 3 and Figure 4.

Example 4

Using the product prepared in the above Example 1, a water-based medicinal tape--a single-layer aqueous medicinal tape which is free of oily sizing, and its appearance and cross-section are shown in Figure 5 and Figure 6. The single-layer aqueous drug tape of the oil-free adhesive comprises a base fabric layer 11, a completely aqueous syrup-containing rubber layer (Product P) 12, and a release paper 14. The water-soluble medicated water-containing rubber layer 12 is coated on one side of the base fabric layer 11 to form a medicated water-containing rubber layer skin-adhesive zone 13. The release paper 14 is peeled off during use, and the skin-adhesive zone 13 of the medicated gel layer is adhered to the skin of the patient. The water-based medicine adhesive tape of the present embodiment adopts the water-based pressure-sensitive adhesive of the invention, has no organic solvent component, and has low skin irritation, and the skin of the affected part is not easy to cause drug rash and allergy, and the water sexy pressure adhesive can be Effectively softens the stratum corneum, which accelerates the rate of absorption of the agent by the skin.

The water-based medicine adhesive tape prepared by the water-based pressure-adhesive agent of the invention can improve the adhesion force of the general water-based adhesive patch and the skin, and the general water-based patch is easy to fall off from the skin, which is different from the general one. Commercially available water-based adhesive tapes are not easy to adhere to the characteristics of the skin. The water-based medicinal adhesive tape prepared by the water-based pressure-adhesive agent of the invention has no oily adhesive in the adhesive region of the patch, so the user's skin is not in contact with the oily adhesive, and the drug rash and allergy are not easy to occur.

The aqueous medicated adhesive tape prepared by the water-based pressure-sensitive adhesive of the present invention may further contain a sodium Bean Kinase extract, a polysaccharide-related compound, or a pH adjuster or the like in the water-soluble medicated water-containing gel layer 12. The nattokinase extract is a protein and a strong thrombolytic enzyme. Polysaccharide-related compounds have been recognized in recent years as compounds that are beneficial to health.

Industrial applicability

As described above, the water-sensitive adhesive composition of the present invention can be made into various pressure-sensitive adhesive tapes, tapes or films. Among them, especially the tape that is in contact with the body is the most industrial use case. When the water-sensitive adhesive composition of the present invention is applied, the pressure-sensitive adhesive tape, tape or film produced by the present invention can be applied to the surface of the skin to produce a long-lasting and strong adhesive effect. Moreover, it does not cause skin rash, flushing, itching and the like.

The present invention has been described with reference to the specific embodiments thereof. It is to be understood that those skilled in the art can make various changes and modifications without departing from the spirit and scope of the invention. Therefore, the scope of the following patent application naturally covers those changes and modifications.

Claims (16)

A water-squeezing pressure-sensitive adhesive composition comprising a copolymer of a) a (meth)acrylic monomer, and b) a mixture of 2 to 150 repeating units of an oxygen-extended ethyl group or an oxygen-extended propyl group or both An ether oligomer of (ethylene oxide), poly(propylene oxide) or (ethylene oxide) / (propylene oxide) copolymer, wherein the weight ratio of the component a) to b) is 99:1 Until 50:50. The composition of claim 1, further comprising a polysaccharide, wherein the polysaccharide is present in an amount of from 0.01 to 15% based on the weight of the components a) and b). The composition of claim 2, wherein the polysaccharide is natto extract or chitosan. The composition of claim 1, further comprising polyacrylic acid, wherein the polyacrylic acid is present in an amount of from 0.01 to 15% based on the weight of the components a) and b). The composition of claim 2, further comprising polyacrylic acid, wherein the polyacrylic acid is present in an amount of from 0.01 to 15% based on the weight of the components a) and b). The composition of claim 3, further comprising polyacrylic acid, wherein the polyacrylic acid is present in an amount of 0.01 to 15%, with components a) and b) Weight and benchmark. The composition according to any one of claims 1 to 6, wherein the component a) is a monomer comprising 1-20% of (meth)acrylic acid or alkyl (meth)acrylate (80%) and 80%. a copolymer of -99% of a hydroxyl group-containing (meth)acrylic acid alkyl (meth) acrylate copolymerized on the basis of the weights of components a) and b), wherein the ether group of b) has from 2 to 150 Poly(ethylene oxide), poly(propylene oxide) or (ethylene oxide)/(propylene oxide) copolymerization of repeating units of oxygen or ethyl oxypropyl or a mixture of the two units The ether oligodiol formed by the ether. The composition of claim 7, wherein the hydroxyl group-containing (meth)acrylic acid alkyl (meth) acrylate is hydroxyalkyl acrylate, hydroxyalkyl (meth) acrylate, ω-hydroxy polyether acrylate A base ester or an ω-hydroxy polyether ester of (meth)acrylic acid. The composition of claim 8, wherein the hydroxyl group-containing (meth)acrylic acid alkyl (meth) acrylate is 2-hydroxyethyl acrylate, 2-hydroxyethyl (meth) acrylate, glyceryl acrylate, (meth) acrylate, Pentaeryth ret yl acrylate, Pentaeryth ret yl (meth) acrylate, ω-hydroxydiethylene glycol acrylate Omega-Hydroxyl diethyleneglycolyl acrylate, ω-Hydroxyl diethyleneglycolyl (meth)acrylate, ω-Hydroxyl polyethyleneglycolyl acrylate Or, ω-Hydroxyl polyethyleneglycolyl (meth)acrylate. The composition of claim 7, wherein the alkyl (meth)acrylate monomer in the (meth)acrylic acid or alkylene (meth)acrylate monomer is butyl acrylate. , Butyl (meth) acrylate, 2-ethylhexyl acrylate, 2-ethylhexyl (meth)acrylate . The composition of claim 7, wherein the (meth)acrylic acid (meth)acrylic acid or (meth)acrylic acid alkyl ether (meth)acrylic acid ether ester monomer is an ether acrylate, (methyl Ethyl acrylate, bis- acrylate, bis-(meth) acrylate, wherein the ether group is an oxygen-extended ethyl group having 2 to 150 units or an oxygen-extended propyl group or a mixture of the two Formed by the unit of poly(ethylene oxide), poly(propylene oxide) or (ethylene oxide) / (propylene oxide) copolymer ether oligomer diol. The composition of claim 11, wherein the (meth) acrylate ether ester monomer is ω-Methyl diethyleneglycolyl acrylate, (meth) acrylate ω-甲ω-Methyl diethyleneglycolyl (meth)acrylate, ω-Methyl polyethyleneglycolyl acrylate, ω-methylpolyethylene glycol (meth)acrylate Omega-Methyl polyethyleneglycolyl (meth)acrylate, Ethyleneglycolyl diacrylate, ethylene glycol di-(meth)acrylate (Ethyleneglycolyl di(meth)acrylate), Diethyleneglycolyl diacrylate, Diethyleneglycolyl di(meth)acrylate, Di-acrylic acid poly(B) Poylethyleneglycolyl diacrylate, or Poylethyleneglycolyl di(meth)acrylate. The composition of any one of claims 1 to 6 further comprising 1-10% of a pH adjusting agent based on the weights of components a) and b). The composition of claim 13, wherein the pH adjusting agent is an alcohol amine compound. The composition of claim 14, wherein the alcohol amine compound is ethanolamine, diethanolamine or triethanolamine. An aqueous medicated adhesive tape comprising a base fabric layer and a water-small pressure-sensitive adhesive composition according to any one of claims 1 to 15 which is applied to a surface of the base fabric layer.