TW201414520A - High energy charged particle treatment system - Google Patents

Abstract

The present invention relates to a charged particle treatment system, at least having a particle injection source, a synchrotron, a beam transmission line assembly, a plurality of treatment rooms and a plurality of particle beam scanning apparatuses.

Description

High energy charged particle therapy system

This invention relates to a therapeutic system and, more particularly, to a charged particle therapy system.

Among the different methods of cancer treatment, surgery and radiation therapy are the main methods for local control of tumors. In the past, radiotherapy was based on X-rays, which had strong penetrating power and could treat tumors in deep tissues. However, the disadvantage was that it was easy to damage the surrounding normal tissues at the same time, and the selectivity was poor. A better treatment than X-rays is the use of high-energy radiation particles to achieve higher selectivity for tumor cells and normal tissues during radiation therapy. The main reason for the high-energy radiation particles not being promoted is that the high-energy radiation particle device for medical use itself or the integration with other medical devices is incomplete, so that the treatment depth, location, accuracy and time setting time of each patient are affected. Extreme limitations, unable to meet high standards of medical requirements, can only be used in a small number of cases of cancer diseases. At the same time, the cost is very expensive and it is why it cannot be widely popularized.

The invention provides a charged particle therapy system comprising at least a particle injection source, a synchrotron, a beam transmission line set, a treatment room and a particle beam irradiation device. The particle implantation source provides charged particles, and the charged particles of the particle injection source have an energy specification of 7-19 electron volts (MeV). The synchrotron plus The charged particles provided by the particle injection source accelerate the charged particles to an energy range of 70-300 MeV and output as a particle beam. A plurality of particle beam irradiation devices are disposed in the treatment rooms, respectively. The beam transmission line group transmits the particle beam output by the synchrotron to the particle beam irradiation devices in the treatment rooms to perform irradiation treatment.

In an embodiment of the invention, the particle implantation source in the charged particle therapy system supplies charged particles to the synchrotron in a first direction, and the synchrotron outputs the particle beam in a second direction to cause the particle The beam advances linearly along an extension of the second direction, the angle between the first direction and the second direction being 180 degrees or 270 degrees.

In an embodiment of the invention, the treatment rooms include at least one first treatment chamber located at the end of the extension line along the second direction, and the particle beam linearly enters the first treatment chamber along the extension line.

In an embodiment of the invention, the treatment rooms further comprise a plurality of second treatment rooms located on the bilateral sides of the extension line along the second direction, the particle beams respectively turning to be left and right with respect to the second direction 30 Degrees, 45 degrees or 60 degrees are injected into the second treatment rooms.

In an embodiment of the invention, the treatment rooms further comprise a plurality of second treatment rooms located on a single side of the extension line along the second direction, the particle beams respectively turning to be opposite to the second direction 30 Degrees, 45 degrees or 60 degrees are injected into the second treatment rooms.

In an embodiment of the invention, the treatment rooms in the charged particle therapy system are on the same plane. In addition, the particle injection source and the synchrotron are in the same plane as the treatment rooms.

In an embodiment of the invention, the charged particles used in the charged particle therapy system are protons.

The above described features and advantages of the present invention will be more apparent from the following description.

The invention integrates and constructs a whole set of high-energy charged radiation particle treatment system, which not only reduces the cost and shortens the time required for treatment, but also can popularize the application of high-energy radiation particles in cancer treatment.

1 is a schematic view showing the configuration of a charged particle therapy system according to an embodiment of the present invention. The high-energy charged radiation particle treatment system 10 of the present invention has a structure as shown in FIG. 1, and includes at least a particle injection source 100, a synchrotron 200, a beam transmission line group 300, a treatment room 400, and a particle beam irradiation device 500.

(1) Particle Injection Source 100: The particle source supplies particles to the accelerator to be accelerated by the accelerator, and the particles used in this embodiment are, for example, protons. The particle energy specification required for the particle injection source is 7-19 electron volts (MeV). The particle injection source is, for example, a linear accelerator (Linac) as a particle injection source, and has an energy specification of 7 to 12 MeV; and if, for example, a small cyclotron (baby cyclotron) is used as an injection source, the energy specification is 13 to 19 MeV.

(2) Synchrotron 200: Accelerates the particles injected by the particle injection source 100, and the specification thereof is, for example, within 30 meters of the circumference, preferably within 20 meters of the circumference, and is arranged in a square shape, and accelerates the particles to the energy range. 70-300 MeV.

(3) Beam transmission line group 300: The particle beam P which accelerates the synchrotron 200 to a specific energy, and the beam transmission line group 300 formed by a combination of a beam tube and a turning magnet is transmitted to the treatment room 400 at a specific angle.

(4) Treatment Room 400: The treatment room 400 is defined as a space for treating a patient, and a particle beam irradiation device 500, a related robot arm, and a positioning system are disposed in the treatment room to facilitate positioning and moving the patient.

(5) Particle beam irradiation device 500: After the high-energy particle beam P is transmitted to the treatment room 400, the particle beam irradiation system 500 is used to aim the patient or the lesion to perform high-energy charged particle irradiation treatment. The treatment system is designed to meet the different needs of the patient, and the irradiation area can be up to 30x30x30cm ³ , and the dose position distribution accuracy can be up to 2 mm.

The particle injection source 100 and the synchrotron 200 illustrated in FIG. 1 can be located in the same room or in different rooms. The particle beam P of a specific energy is refracted at a 270 degree turn from the original injection direction. The treatment room 400 includes a treatment room 400A and a treatment room 400B. Basically, the treatment rooms 400 are arranged on the same plane, that is, on the same floor of the building. The particle injection source 100 and the synchrotron 200 can be located on the same plane (floor) as the treatment rooms 400. The synchrotron 200 should be in the same plane (floor) as the treatment rooms 400, but the particle injection source 100 may be located on the other floor (upper layer) because the particle beam P exit direction is 270 degrees away from the original particle injection direction. Or the next layer). The emission direction of the high-energy particle beam P is set to the horizontal axis (X-axis), and a treatment room 400A is disposed at the end of the horizontal axis extension line, and the high-energy particle beam P can enter the treatment room 400A along the horizontal axis. The treatment room 400B can be bilaterally arranged with respect to the horizontal axis extension line with respect to the horizontal axis (X axis) The beam transmission line group 300 can respectively turn the high-energy particle beam P into a treatment, and the particle beam P is injected into the treatment rooms 400B respectively by 45 degrees to the horizontal axis (which appears to be 45 degrees above and below the horizontal axis). . For the treatment chamber 400B disposed bilaterally, the particle beam P may be injected into the treatment rooms 400B at 45 degrees to the left or 45 degrees to the right with respect to the horizontal axis. Although the angle is 45 degrees in this embodiment, the angle is not limited to 45 degrees and may be selected from the range of 30-60 degrees.

Since the high-energy particle beam P emitted by the charged particle therapy system of the present invention is bilaterally transmitted to the treatment room 400, the entire system can be more elastic in planning, and the utilization of the particle beam is greatly improved. The space utilization rate of the medical site.

As for the particle beam irradiation device 500 located in the treatment room 400, relative to the conventional fixed bed or patient position, the lens head (Gantry) or the rotating function irradiation unit rotates the particle beam to emit the traveling direction to irradiate the different cancerous positions. In the treatment room 400 of the present invention, the mechanical arm can be used to carry the bed, and the bed and the patient position can be rotated or moved in a three-dimensional manner, and the irradiation mode of the fixed incident angle particle beam can be combined to eliminate the traditional machine head from being emitted at different rotation angles. The space requirements of the large deflection magnets required for the particle beam streamline the cost of the treatment room. Of course, reducing the use of expensive conventional handpieces can also significantly reduce overall system manufacturing costs. At the same time, it can also reduce the difficulty of maintaining a fixed position for a long time, thereby improving the accuracy of the overall positioning of the system.

The particle beam irradiation device 500 located in the treatment room simultaneously integrates other medical instruments, including computed tomography (in-room CT), and magnetic resonance imaging. Image (MRI), positron tomography (PET) or laser image localization navigation system to check, locate and treat patients. Integrating a variety of therapeutic aids in the treatment room not only avoids the waste of medical resources caused by the parallel inspection of multiple medical instruments, but also enhances the diversification of radiation particle treatment targets.

2 is a schematic view showing the configuration of a charged particle therapy system according to another embodiment of the present invention. With respect to the system configuration of FIG. 1, the particle injection source 100 illustrated in FIG. 2 and the synchrotron 200 are in the same room, and the particle beam P of a specific energy is refracted 180 degrees from the original injection direction. The treatment room 400 includes a treatment room 400A and a treatment room 400B. The particle injection source 100 and the synchrotron 200 can be located on the same plane (floor) as the treatment rooms 400. The emission direction of the high-energy particle beam P is set to the horizontal axis (X-axis), and a treatment room 400A is disposed at the end of the horizontal axis extension line, and the high-energy particle beam P can enter the treatment room 400A along the horizontal axis. With respect to the horizontal axis (X-axis), the treatment room 400B can be arranged unilaterally with respect to the horizontal axis extension line. In the treatment room 400B, which is unilaterally arranged in Fig. 2, the particle beam P can be selectively injected into the treatment rooms 400B only in a unilateral manner so as to be 45 degrees with respect to the horizontal axis. The treatment room 400B in the unilateral configuration of Figure 2 can be between 2 and 4.

3 is a schematic diagram showing the configuration of a charged particle therapy system according to still another embodiment of the present invention. Disposed on the same plane, the treatment rooms 400 include the treatment room 400A located at the end of the extension line of the high energy particle beam P (set to the horizontal axis / X axis), and the high energy particle beam P can enter the treatment room 400A along the horizontal axis. . With respect to the horizontal axis (X-axis), the treatment rooms 400B and 400B' are bilaterally arranged symmetrically with respect to the horizontal axis extension line, and the beam transmission line group 300 can turn the high-energy particle beam P separately, so that the particle beam P is opposed to The horizontal axes are respectively injected into the treatment rooms 400B and 400B' by 45 degrees left and right and 30 degrees left and right, respectively.

4 is a partial schematic view showing a configuration of a charged particle therapy system in accordance with an embodiment of the present invention. 4 illustrates the particle injection source 100 injecting particles into the synchrotron 200 (as indicated by the dashed arrow). When the synchrotron 200 accelerates the charged particles to the desired energy range, the particle beam P of the specific energy is 270 from the original injection direction. The degree of refraction is shown (indicated by the arrow) and transmitted to the treatment room 400 through the transmission line 300 (see Fig. 1).

Since the invention integrates a small cyclotron (or a linear accelerator) as a particle source, and accelerates with a synchrotron to reach a range of energy of the extracted particles of 70-300 MeV, and then is extracted by one side corresponding to the injection direction of 270 degrees, this non- Straight line configuration saves configuration space and achieves the goal of reducing overall system size. The use of small cyclotrons as particle sources, due to their small diameter (generally less than 1.5 m), also helps to reduce system size. Of course, when the space is sufficient, the particle source 100 and the synchrotron 200 can also be arranged in a straight line (Fig. 2), and are drawn by one side corresponding to the injection direction by 180 degrees.

FIG. 4 also depicts the structural configuration of the synchrotron 200. In the accelerator, the particles move in a closed vacuum pipeline, and it is necessary to effectively control the turning, focusing, introducing, and extracting motion trajectories of high-speed moving particles, and must rely on the control formed by the high-precision design of the magnet component on the particle motion trajectory. magnetic field. The synchrotron 200 is a square configuration that uses four 90-degree dipole magnets (Dipole) 202 to control the turning of the particle beam, with four quad-quadrupoles 204 for beam focusing and a six-pole magnet. (Sextupole) 206 for beam energy correction and compensation. The synchrotron 200 is a synchrotron that can be accelerated to an energy range of 70-300 million electron volts (MeV).

In general, the synchrotron is a combination of different types and quantities of magnets into a closed loop to achieve continuous acceleration. The invention aims to reduce the overall size of the system and the cost of construction by designing and calculating the minimum number of magnets and the simplest magnet construction position, and at the same time, the lower the required magnet cost, the lower the required cost. The number of magnets is reduced and the stability is thus increased, so that the subsequent maintenance is also simpler.

The main advantages of the complete set of high-energy charged radiation particle therapy systems integrated for the present invention include:

1. Simple area, the system of the present invention can provide more therapeutic charged particle radiation energy under the same footprint.

2. The charged particle beam is simultaneously transmitted to multiple treatment rooms on both sides, shortening the maintenance interval of the treatment system and increasing the turnover rate of the treatment system.

3. Improve the positioning accuracy of patients receiving charged particle radiation therapy.

4. Integrate the clinically needed auxiliary equipment in the same treatment room to shorten and simplify the pre-processing time and process required for radiotherapy.

Although the present invention has been disclosed in the above embodiments, it is not intended to limit the invention, and any one of ordinary skill in the art can make some modifications and refinements without departing from the spirit and scope of the invention. The scope of the invention is defined by the scope of the appended claims.

10‧‧‧High-energy charged radiation particle therapy system

100‧‧‧Particle injection source

200‧‧‧Sync Accelerator

202‧‧‧ two-pole magnet

204‧‧‧ four-pole magnet

206‧‧‧Six-pole magnet

300‧‧‧beam transmission line set

400, 400A, 400B, 400B’‧‧‧ treatment rooms

500‧‧‧Particle beam irradiation device

1 is a schematic view showing the configuration of a charged particle therapy system according to an embodiment of the present invention.

2 is a schematic view showing the configuration of a charged particle therapy system according to another embodiment of the present invention.

3 is a schematic diagram showing the configuration of a charged particle therapy system according to still another embodiment of the present invention.

4 is a partial schematic view showing a configuration of a charged particle therapy system in accordance with an embodiment of the present invention.

10‧‧‧High-energy charged radiation particle therapy system

100‧‧‧Particle injection source

200‧‧‧Sync Accelerator

300‧‧‧beam transmission line set

400, 400A, 400B‧‧ ‧ treatment room

500‧‧‧Particle beam irradiation device

Claims (15)

A charged particle therapy system comprising at least: a particle injection source that provides charged particles, and a charged particle energy specification of the particle injection source is 7-19 electron volts (MeV); a synchrotron that accelerates the supply of the particle injection source Charged particles, accelerate charged particles to an energy range of 70-300 MeV and output as a particle beam; a plurality of treatment chambers; a plurality of particle beam irradiation devices disposed in the treatment rooms; and a beam transmission line group to output the synchrotron The particle beams are respectively delivered to the particle beam irradiation devices in the treatment rooms for irradiation treatment. The charged particle therapy system of claim 1, wherein the particle injection source supplies charged particles to the synchrotron in a first direction, and the synchrotron outputs the particle beam in a second direction to cause the particle beam Advancing along an extension line in the second direction, the angle between the first direction and the second direction is 180 degrees. The charged particle therapy system of claim 1, wherein the particle injection source supplies charged particles to the synchrotron in a first direction, and the synchrotron outputs the particle beam in a second direction to cause the particle beam Advancing along an extension line in the second direction, the angle between the first direction and the second direction is 270 degrees. The charged particle therapy system of claim 1, wherein the treatment rooms comprise at least one first treatment room, located along the second side The end of the extension line is directed, and the particle beam enters the first treatment room along the extension line. The charged particle therapy system of claim 4, wherein the treatment rooms further comprise a plurality of second treatment rooms located on a single side of the extension line along the second direction, the particle beams respectively turning The second treatment rooms are respectively injected into the 45-degree manner with respect to the second direction. The charged particle therapy system of claim 4, wherein the treatment rooms further comprise a plurality of second treatment rooms located on a bilateral side of the extension line along the second direction, the particle beams respectively turning to be opposite The second treatment chambers are respectively injected into the second direction and the left and right 45 degrees. The charged particle therapy system of claim 4, wherein the treatment rooms further comprise a plurality of second treatment rooms located on a single side of the extension line along the second direction, the particle beams respectively turning The second treatment rooms are respectively injected into the 30-degree manner with respect to the second direction. The charged particle therapy system of claim 4, wherein the treatment rooms further comprise a plurality of second treatment rooms located on a bilateral side of the extension line along the second direction, the particle beams respectively turning to be opposite The second treatment chambers are respectively injected into the second direction by 30 degrees. The charged particle therapy system of claim 4, wherein the treatment rooms further comprise a plurality of second treatment rooms located on a single side of the extension line along the second direction, the particle beams respectively turning The second treatment rooms are respectively injected 60 degrees with respect to the second direction. The charged particle therapy system of claim 4, wherein the treatment rooms further comprise a plurality of second treatment rooms located along the second side On the bilateral sides of the extension line, the particle beams are respectively turned and injected into the second treatment chambers in a manner of 60 degrees left and right with respect to the second direction. The charged particle therapy system of claim 4, wherein the treatment rooms further comprise a plurality of second treatment rooms located on a single side of the extension line along the second direction, the particle beams respectively turning At least two or more angles are respectively incident on the second treatment chambers relative to the second direction, the two or more angles being between 30-60 degrees. The charged particle therapy system of claim 4, wherein the treatment rooms further comprise a plurality of second treatment rooms located on a bilateral side of the extension line along the second direction, the particle beams respectively turning to be opposite At least two or more angles are respectively injected into the second treatment chambers in the second direction, and the two or more angles are between 30-60 degrees. The charged particle therapy system of claim 1, wherein the treatment rooms are on the same plane. The charged particle therapy system of claim 13, wherein the particle injection source and the synchrotron are in the same plane as the treatment rooms. The charged particle therapy system of claim 1, wherein the charged particles are protons.