201231103 六、發明說明： 【發明所屬之技術領域】 本發明係關於一種吸入器。 【先前技術】 本發明已特別設計用於具有一大致香煙形狀的主體的 杈擬香煙裝置。然而，本發明係關於對於此一裝置的出 口閥的一發展，其在吸入器的領域具有較廣的應用，舉 例而言，用於諸如氣喘吸入器的口服藥物遞送的醫療吸 入器。 在香煙替代品的領域，已有數種建立一模擬香煙的提 4。此一裝置具有超越傳統尼古丁替代品療法（諸如貼 布及口香糖）的數種優點，其重新建立吸煙的實體動作 (此對一吸煙者而言係為心裡上重要的），且亦能夠以更 接近地複製上瘾的吸煙者所欲的一香煙的藥物動力效 應，而以一劑量遞送尼古丁。因此，一吸煙者能夠獲得 類似來自一香煙的「癮頭」，而無須面對從一貼布或口香 糖緩慢的釋放，其無法產生此一瘾頭而導致無法預期的 服用及差的渴求成績及中斷比率。 一種模擬香煙具有可吸入混合物的一儲藏器及—出口 閥，該出口閥舉例而言，可藉由按壓一按鈕或咬住—香 煙的端而觸發。然而，用於開啟閥的較佳機制係為提供 一呼吸啟動閥，因為此確保香煙將僅當使用者以—正常 201231103 香煙的方式吸吮在裝置上時才配給。 wo 02/45783 揭露—接銥 α Λ 種樂配給器，其具有一閥的安 排適以配給一計量的南丨旦 的劑$。此採取彈性管的形式，其纏 繞在一閥物件的四周且具有-對扭結。在扭結之間的管 的部份能夠保留待配給的藥物的一經計量的劑量。當一 使用者吸η允在配认哭u oD , ^益上時，閥物件移動開啟下游扭結以201231103 VI. Description of the Invention: TECHNICAL FIELD OF THE INVENTION The present invention relates to an inhaler. [Prior Art] The present invention has been specifically designed for a virtual cigarette device having a body having a substantially cigarette shape. However, the present invention relates to a development of an outlet valve for such a device, which has a wide range of applications in the field of inhalers, for example, medical inhalers for oral drug delivery such as asthma inhalers. In the field of cigarette substitutes, there have been several attempts to establish a simulated cigarette. This device has several advantages over traditional nicotine replacement therapy (such as patches and chewing gum), which re-establishes the physical action of smoking (which is important for a smoker) and can also be more The drug kinetic effect of a cigarette desired by an addicted smoker is closely replicated, while nicotine is delivered in one dose. Therefore, a smoker can obtain an "addiction" similar to that from a cigarette without having to face a slow release from a patch or chewing gum, which can not produce this addiction and lead to unpredictable taking and poor cravings and interruptions. ratio. A reservoir and an outlet valve for simulating a cigarette having a respirable mixture, which can be triggered, for example, by pressing a button or biting the end of the cigarette. However, a preferred mechanism for opening the valve is to provide a breath-activated valve, as this ensures that the cigarette will only be dispensed when the user sucks on the device in the manner of a normal 201231103 cigarette. Wo 02/45783 Exposure—The 铱α Λ Λ 配 , , , , , , , , , , 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 This takes the form of an elastic tube that wraps around a valve member and has a - torsion knot. The portion of the tube between the kinks is capable of retaining a metered dose of the drug to be dispensed. When a user sucks and allows the crying u oD, the valve object moves to open the downstream kinks to
便配給經計量的备丨I A 劑里當呼氣時，閥以相反的方向移動 :閉下游扭結且開啟上游扭結，以允許介於担結之間的 S的伤重新填充藥品。此安排始終僅允許―使用者吸 入一次經計量的劑量，不論使用者在裝置上吸吮多久。 US 4’393’884揭露具有大的有彈力的「舌片」的此一 裝置’其具有-流動路徑通過其中。此舌片偏移至並非 與香煙的出口對齊的—第—位置，且可被吸。允至與香煙 的出口對齊的-第二位置，以提供從儲藏器至出口的一 流動路徑。此-裝置在第一位置難以密封。其亦將需要 相當的力量來吸口允舌片i開啟位置來抵抗_ $位的彈酱 的動作及舌片構件相對大的質量，其將難以返回關閉位 置，意味著在吸吮力已經被移除之後配給仍將繼續。 US 6,889’678揭露具有一呼吸啟動閥的—模擬香煙的 另一範例。此專利揭露數個範例。此等範例之一者具有 —對磁鐵，其中一個磁鐵藉由一彈性薄膜定位，當施加 吸吮力至裝置時，其允許磁鐵移動而分開。此步驟從儲 藏器開啟一流動路徑。然而，此機制相當地複雜，具有 迂迴的流動路徑而易於阻礙來自儲藏器的混合物的遞 201231103 送，且自濟係為「一 ^ ·’、’、二元的」，因為閥係為開啟或關閉任一 者。此並不提俾# i + 曰 y、更用者藉由改變吸吮的程度而調節流動 量的能力。篦-# y t 乐一觀例係為彈簧偏移的活塞，其軸向地移When the exhaled air is dispensed into the metered preparation, the valve moves in the opposite direction: the downstream kinks are closed and the upstream kinks are opened to allow the S between the stalks to refill the drug. This arrangement always allows only the user to inhale a metered dose, no matter how long the user sucks on the device. US 4'393' 884 discloses such a device' having a large resilient "tab" having a flow path therethrough. The tab is offset to a - position that is not aligned with the outlet of the cigarette and can be sucked. A second position aligned with the outlet of the cigarette is provided to provide a flow path from the reservoir to the outlet. This - the device is difficult to seal in the first position. It will also require considerable force to allow the mouthpiece i to open position to resist the action of the _$ position of the sauce and the relatively large mass of the tongue member, which will be difficult to return to the closed position, meaning that the suction force has been removed The rationing will continue afterwards. Another example of a simulated cigarette having a breath actuating valve is disclosed in US 6,889'678. This patent discloses several examples. One of these examples has a pair of magnets, one of which is positioned by an elastic film that allows the magnet to move apart when a suction force is applied to the device. This step opens a flow path from the reservoir. However, this mechanism is quite complicated, has a roundabout flow path and is easy to hinder the delivery of the mixture from the reservoir 201231103, and the self-reliance system is "one ^ · ', ', binary" because the valve system is open or Turn off either. This does not mention i# i + 曰 y, the ability of the user to adjust the flow by changing the degree of sucking.篦-# y t Le Yi Guan is a spring-biased piston that moves axially
動以在一中水J：曰rK BH 、于中開啟一通道。此軸向地可移動活塞實 際上並非所欲，因發 口赞現克服彈簧偏移力所需的吸吮力的 級別太高而盔法音防杜m …、古貫際使用。而且，在開啟位置中的流動 路徑係從桿外、至活塞中、且再回到桿中，使其再-次 地某種&度上係迁迴的。第三範例依賴—磁性介面，其 上之力置係藉由葉片的一系統克服，該等葉片圍繞著裝 置的軸旋轉’冑此沿著-凸輪表面移動以，拉動磁性閥 物件離開其封σ。再_次地，此遭遇複雜、缺乏控制、 及一迂迴流動路徑的問題。 本公司本身較早應用的WO 2009/001082揭露兩個不 同的呼吸啟動裝置。此等裝置之第一者具有一對葉片系 統可圍繞著垂直於裝置的主軸的一軸旋轉，以對齊來自 儲存器與出口孔洞的一孔洞而能夠配給。此等裝置之第 二者具有一對樞紐葉片，其被向下吸吮抵抗返回彈簧的 動作’以便開啟流動路徑。此同時解決某些問題，因其 提供一簡單的機制及一軸向流動路徑，吸允以觸發裝置 所需的力量比較大，且因此使用者可在系統上輸出較少 的控制來釋放可改變的劑量，根據吸入的進氣而可大可 小 〇 【發明内容】 201231103 本發明係針對一吸入器提供一改善的呼吸啟動閥，且 特定而言，係針對一模擬香煙。 根據本發明，提供一吸入器，其包含： 可吸入混合物的一儲存器； 於端的出口’可吸入混合物透過該出口而排出；及 在一端及儲存器之間的一非計量呼吸啟動閥，該呼吸 啟動閥包含一流動路徑從儲存器延伸至出口端，流動路 徑的至少一部份係為一可變形管，及一鉗夾元件，當無 吸入力量施加至裝置時，钳夾元件將可變形管夾緊而關 閉，且當施加吸入力於出口時，將該管釋放而開啟，以 提供從儲藏器至出口的不中斷流動。 藉由鉗夾一可變形管，本發明具有數種優點。鉗夾機 制係為單純的，因其總體所需僅為一可移動組件以夾緊 管而並非複雜。再者，因為流動路徑係沿著一開口的管， 所以無須迂迴的流動，否則其可能需要流動在諸如us 6,889,678中的該些未座落的閥組件。允許不十斷流動的 非計量閥允許-使用者調整其從吸人器接收的劑量，因 該閥將於使用者吸吮時持續配給。 夾緊的管的安排對一未計量的劑量功不可沒。而且， 在提供甜夹元件而有效率地「啪的一聲」開啟以提供開 啟或關閉任-者的-「二元」裝置與裝置—起的同時， 夾緊的可變形f係良好地適於—裝置，其中管的開啟程 度係正比於吸吮的力道。以呼吸可操作且根據吸入輪廓 的改變的抵抗的此一出口閥係藉由使用者以—連續的方 201231103 式自我滴定吸入的劑量而啟動。此具有以下岸用首先 用於戒终吸入裝置，其中使用者希望以符合其需求的方 式自我滴定其尼古τ的劑量，但亦應用於其他範圍，例 如—疼痛管理、糖尿病、氣喘、及COPD，其中透過口 服的途控來自我官制劑量係為較佳地。 如上所述及入器可為用於任何可吸入藥品混合物的 -藥物遞送吸入器。然而，吸入器較佳地為具有一大致 香煙形狀的主體的一模擬香煙裝置。在此情況中，可吸 入混合物較錢包括尸匕古丁或一尼古丁衍生物或其鹽 類。另一方面，該吸入器可為複製吸煙的實體動作而在 混合物中無須尼古丁的—模擬香煙。或者，混合物可包 括控制患者的止痛藥、消炎藥、支氣管擴張劑、抗痙攣 藥、抗病毒藥或鴉片。 鉗夾元件可以任何適合的裝置形成，當施加吸吮至出 口時，其可釋放可變形管。舉例而言，此鉗夾元件可為 一電子流動感測器及一螺線管的結合，以移動鉗夾元 件。然而較佳地，鉗夾元件係一機械元件，其藉由當施 加吸吮於出口時所造成的一壓力差而被移動。 該機械元件可採取WO 2009/001082中的第二實施例 的一對葉片的形式’其中機械元件在關閉位置中夾緊於 葉片之間且曰葉片朝向空氣穿流的方向移轉時被釋放。 然而較佳地，鉗夾元件係為一伸長的葉片，其樞紐地 固定於一端且縱向延伸於吸入器之中，葉片可旋轉 (pivotable )於管被關閉的—第一位置中，及其釋放管 201231103 以提：流動路徑的—第二位置中。可存在—單一葉片， 其抵罪吸入器的—固定部份而鉗夾可變形管戋可 一對此等葉片於管被鉗夹之處。 卓jC it地’ 一個葉片 入器具有横跨於葉片 克服偏移力量。 或各葉片被偏移至關閉位置令且吸 上建立一壓力差的一流動路徑，其 一個葉片4各葉片可暴露於空氣的一通過流，使得當 者在出口上吸吮時，空氣的通過流衝擊在葉片的 外表面上’將其向内移動。然而較佳i也，-個葉片戌 各葉片藉&彈性薄膜支撐。此彈性薄膜建立其中、裝二 葉片的-腔室’且對開口開啟否則密封，以在葉片的相 對側上的薄膜的面對大氣壓力開啟。當-使用者在出口 上吸吮時，其在腔室中建立-負的壓力，以移動葉片， 且薄膜收縮以允許此動作。此提供非常有效率的機制用 於傳遞吸吮力量至葉片。 較佳地，可變形管係一喷嘴，其亦整體地與—出口孔 洞一起提供，該出口孔洞係為流動路徑最窄的部份。 在此情況中，較佳地，噴嘴在其上游端具有一向外凸 出的垓狀凸緣，其符合在流動路徑的一鄰接部份的一下 由端之中。 【實施方式】 口閥的一改 本發明係關於用於一呼吸啟動香煙的出 201231103 善，且此處將僅具體地說明本發明的此態樣。對於香煙 裝置及其再裝滿機制的其餘結構的細節，請參考 2009/001078 ° 根據本發明的吸入器的第一範例係顯示於第丨至3圖 中。 裝置具有一殼體1，其由第1圖中所顯示的一主要底 座2及一包體物件3所組成。此係藉由標籤4而握於適 當位置。在殼體中，存在含有可吸入混合物的一儲藏器 5。此較佳地被加壓，但亦可以一未加壓的儲藏器與文托 利喷嘴（Venturi nozzle)結合而運作，以在錯藏器上產 生一增強的吸吮力量，或含有易於在室溫下揮發的物質 的一未加壓的儲藏器。其可透過填充閥6而如w〇 2009/001082中所述而可重新裝滿，或該裝置可為一次性 使用裝置，或可經安排使得儲藏器5係一可替換組件。 呼吸啟動閥7係位於一出口端8及儲藏器5之間。呼 吸啟動閥經安排，使得當一使用者在出口端8吸n允時， 呼吸啟動閥7開啟，以允許來自儲藏器5的可吸入混人 物被吸食。 在出口端的殼體具有兩個孔洞。此等孔洞之第一者係 吸吮孔洞9，其與一腔室1〇連通，而將於以下更詳細的 說明，且第二者係一出口孔洞Π，可吸入混合物從此孔 洞配給，而亦於以下更詳細說明。從第3圖明顯可見， 出口孔洞11係提供於一分開的組件丨2上。 一出口路徑13係界定於儲藏器5及出口孔洞i i之間。 10 201231103 出口路徑的-部份係由可變形管狀元件μ提供。 此管狀元件藉由現在將說明的—機制，在第丨圖所顯干 的關閉位置及第2圖所顯示的開啟位置之間移動。 此機制包含-樞紐固定的葉片15及一薄膜Μ。樞紐 ，定的葉片於最靠近出口端8的端具有一樞紐i7，及沿 者其長度且離出口端越遠漸小的一中央加強肋。在中 點的四周，對葉片15提供一凹槽19，用於容納一彈簧 20該彈簧偏移葉片至第i圖所顯示的關閉位置中。一 顆片係在凹槽19的下方，其具有一三角的剖面而配 置成將從葉片15提供的力量透過—窄的面積施加至可 ，形管14。葉片15由隔膜16支擇，隔膜於其端m 密封至殼體。此密封腔室1〇而非密封吸吮孔洞9。 薄膜16的下方側24係對A氣壓力開啟，料透過殼 體1存在的一滲漏路徑，其未顯示於圖式中因其延伸 於出口路徑1的四周且因此未顯示於第圖 中。 虽一使用者在第1圖所顯示的配置中的一裝置的出口 端8上吸吮時’吸吮力藉由吸吮孔洞9透過孔洞連通 至腔至ίο，從而降低此腔室中的壓力。此造成葉片 相對於彈簧20的動作而被抬昇至第2圖中所顯示的位 置’將隔膜變形成第2圖中所顯示的配置，且抬昇顆片 21以允許可變形管開啟，從而允許來自儲藏器5的可吸 入混合物沿著出口路徑13透過可變形管14且透過出口 孔洞11而排出。由使用者施加的吸吮的程度將決定葉片 201231103 1 5移動的限度’且因此決定使用者接收的混合物的量。 在使用者停止吸吮之際，大氣壓力將透過吸吮孔洞9返 回至腔室10,且彈簧20將葉片返回第1圖的位置，從 而夾緊管14為關閉。 一吸入器的一第二範例係顯示於第4至6圖中。此範 例亦提供一可變形管14、一儲藏器5及出口端8，但該 機制具有些微差異。在第4圖的關閉位置中，可變形管 鉗夾於一彈簧夾31的一對顎片30之間。此夾31在第4 圖中顯示偏移至第一位置中。吸入器具有一出口孔洞 32，其從儲藏器5經由可變形管14透過出口孔洞32及 多個吸允孔洞3 3而完成一流動路徑，該多個吸吩孔洞提 供對一内部腔室34的吸吮。在此範例中，存在一對樞紐 地固定的葉片3 5沿著裝置的相對側縱向延伸。葉片之各 者連接至一 L形的托架36,該L形的托架之一者係顯示 於第6圖中。此L形的托架延伸至分別的顎片30中，且 因以下說明的原因’而有效率地四周觸及至可變形管Μ 的相對側。 長·供對出口孔洞37於殼體1，每一者孔洞用於各葉 片。畲一使用者在出口端8吸吮時，吸吮力量經由吸吮 孔洞34而將空氣汲取透過入口孔洞37至腔室34中，從 而對葉片35施加向内壓力。由於向内壓力，f片向内旋 轉至第5圖所顯示的位置。L形托架36意味著上部葉片 35的向下動作將下部顎片30向下移動，且下部葉片35 的向上動作將上部顎片30向下移動，從而如第5圖中所 12 201231103 顯示的開啟可變形管14，以配給可吸入混合物。當移除 吸吩力量時，橫跨葉4 35的壓力差被移除且彈簧夾31 的恢復力將顎片30返回第4圖中所顯示的位置。’ 現將參考第7圖說明一可變形管狀物件的一替代安 排0 葉片15、薄膜16及其他組件係廣泛地參照先前範例 所說明的該等而相同。在此範例中的主要差異係可變形 管狀物件14,的配置，且此等差異係將於以下完全說明。 本質上，先前在分開的組件中的孔洞u現被整合至管 狀物件1 4 ’而為孔洞11 ’。此且古甘+ 此具有某些額外的益處。首先， 藉由一單一組件替換兩個組件， • 丁 ία 口路徑所需的整體空 間被減少。此允許諸如葉片15及薄膜16的其他物件的 尺寸增大。此依次增加裝置的敏感性，因其更有效率地 將^的呼吸力量轉換成開啟流動路徑的動作。此對具有 受損的肺部功能能力的使用去仫故 文用考係為重要的。次要地，藉 由消除管狀物件14及具有巩、.η "以μ 负孔洞11的盤之間的一封口的 需求’裝置的製造可被簡化。并冰 此外’此消除於此介面的 可能滲漏。而且，孔洞盤14，於苴 方 八上游鳊被密封至出口路 控13的方式亦被修改。在复 你/、上游端’管狀物件14,提供 一向外凸出的環狀凸緣40。舲3人+人， 此将合於出口路徑13的上 游端之中。此比結合管狀物件 件14在適當位置提供更可靠 的密封安排。結果’新的嘴嘴讯 貝哭认什可含有一加壓的組成 物而在更長的時段無滲漏，卫山以 丘因此增加裝置中的組成物 的穩定度以及在更長的時段仅 又保持較尚的容量。 13 201231103 管狀物件14,於特定部份可為不同厚 緊接於凸绫4Λ ^ 叩。在 緣4〇下游的喷嘴壁上的環箍應力（h stresses ) a# % , p 苴_ 為最大。然而，對於管狀物件14,的中段， '、1片21密封管狀元件，可用減少厚度的材料，以允 許更容易的鉗夹動作。 兄 &佳地’ #狀物件14’具有介於2〇A及8〇a之間的蕭 又（shore hardness )，最佳地為30A至40A。於其 的P伤，壁可為〇 5 mm厚，且於其最薄的部份可為 0.18 rn m Ji / -Λ* 、 〜了在吸入器上遞送最佳性能用於將噴霧 送達肺部的系統，出σ孔洞u較佳地係介於G l _及 5 1111X1寬，但較佳地為0.2至0_3 mm且最佳為〇·2 mm 寬。在管狀物件14’中遠離出口孔洞u的内部通道係較 佳地"於0.2 mm及0.6 mm寬，較佳地介於〇·3 mm及 〇·5 mm之間且最佳地為0.4 mm。 【圖式簡單說明】 根據本發明的吸入器的範例現將參考隨附圖式而說 明’其中： 第1圖係在一關閉位置中的一第一吸入器經由一透視 圖的分區； 第2圖係在開啟位置中的一類似視圖； 第3圖係第1及2圖的吸入器的一展開的透視圖； 第4圖係在關閉位置中的一第二吸入器經由一透視圖 14 201231103 的一剖面； 第5圖係在開啟位置中的一類似視圖；及 第6圖係從第二範例的出口端的一透視圖，顯示咦除 了外部殼體，以顯示夾緊機制；及 第7圖係可變形管狀元件的一替代安排的一剖面。 【主要元件符號說明】 1 殼體 17 樞紐 2 主要底座 18 中央加強肋 3 包體物件 19 凹槽 4 標籤 20 彈簧 5 儲藏器 21 顎片 6 填充閥 22 端 7 呼吸啟動閥 23 端 8 出口端 24 下方側 9 吸B允孔洞 25 孔洞 10 腔室 30 顎片 11 出口孔洞 31 彈簧夾 12 分開的組件 32 出口孔洞 13 流動路徑 33 吸吮孔洞 14 可變形管 34 内部腔室 15 葉片 35 葉片 16 薄膜 36 L形托架 15 201231103 37 出口孔洞 40環狀凸緣 16Move in a medium water J: 曰rK BH, open a channel in the middle. This axially movable piston is actually not desirable, because the level of sucking force required to overcome the spring biasing force is too high, and the helmet sound is prevented from being used. Moreover, the flow path in the open position is from the outside of the rod, into the piston, and back to the rod, causing it to relocate a certain degree of & The third example relies on a magnetic interface on which the force is overcome by a system of blades that rotate around the axis of the device to move along the surface of the cam to pull the magnetic valve object away from its seal σ . Again, this encounter is complicated, lacks control, and has a problem with the flow path. WO 2009/001082, which was previously applied by the company itself, discloses two different breathing starters. The first of these devices has a pair of vane systems that are rotatable about an axis perpendicular to the main axis of the device to align a hole from the reservoir and the exit aperture for dispensing. The first of these devices has a pair of hinge vanes that are sucked downwardly against the action of the return spring to open the flow path. At the same time, some problems are solved because it provides a simple mechanism and an axial flow path, and the force required to trigger the device is relatively large, and thus the user can output less control on the system to release the changeable. The dose may be large or small depending on the inhaled intake air. [Invention] The present invention provides an improved breathing start valve for an inhaler, and in particular, for a simulated cigarette. According to the present invention, there is provided an inhaler comprising: a reservoir of a breathable mixture; an outlet at the end of the breathable mixture being discharged through the outlet; and a non-metering breath actuating valve between the end and the reservoir, the The breathing actuating valve includes a flow path extending from the reservoir to the outlet end, at least a portion of the flow path being a deformable tube, and a jaw member, the jaw member being deformable when no suction force is applied to the device The tube is clamped closed, and when a suction force is applied to the outlet, the tube is released to open to provide uninterrupted flow from the reservoir to the outlet. The present invention has several advantages by clamping a deformable tube. The jaw system is simple, as the overall requirement is only a movable component to clamp the tube and is not complicated. Moreover, because the flow path is along an open tube, there is no need for a meandering flow that would otherwise require flow of such unsituated valve assemblies such as us 6,889,678. A non-metering valve that allows for a non-stop flow allows the user to adjust the dose it receives from the inhaler as the valve will continue to dispense when the user sucks. The arrangement of the clamped tubes contributes to an unmetered dose. Moreover, while providing a sweet clip element and efficiently "squeaking" to open or close any of the "binary" devices and devices, the clamped deformable f system is well adapted. In the device, wherein the degree of opening of the tube is proportional to the force of the suction. The outlet valve, which is breathable and resistant to changes in the suction profile, is activated by the user by self-titrating the inhaled dose in a continuous manner 201231103. This has the following shore use first for use in a terminal inhalation device where the user wishes to self-titrate the dose of NicoT in a manner that meets his or her needs, but also applies to other ranges, such as - pain management, diabetes, asthma, and COPD. Among them, the amount of oral administration is preferably from the official preparation. As mentioned above, the introducer can be a drug delivery inhaler for any inhalable drug mixture. However, the inhaler is preferably a simulated cigarette device having a body in the shape of a substantially cigarette. In this case, the inhalable mixture includes corpse gudin or a nicotine derivative or a salt thereof. On the other hand, the inhaler can be used to replicate the physical action of smoking without the need for nicotine-simulated cigarettes in the mixture. Alternatively, the mixture may include an analgesic, an anti-inflammatory, a bronchodilator, an anti-spasm, an antiviral or an opium that controls the patient. The jaw member can be formed by any suitable means that releases the deformable tube when suction is applied to the outlet. For example, the jaw member can be a combination of an electronic flow sensor and a solenoid to move the jaw member. Preferably, however, the jaw member is a mechanical member that is moved by a pressure differential caused by the application of suction to the outlet. The mechanical element may take the form of a pair of vanes of the second embodiment of WO 2009/001082 'where the mechanical element is clamped between the vanes in the closed position and the vane is released in the direction of air flow. Preferably, however, the jaw member is an elongated blade that is pivotally secured to one end and extends longitudinally into the inhaler, the blade being pivotable in the first position in which the tube is closed and released Tube 201231103 to mention: in the flow path - in the second position. There may be a single blade that defies the fixed portion of the inhaler and the jaw deformable tube can be such that the blade is clamped where the tube is clamped. Zhuo jC it's a blade with a cross-over blade that overcomes the offset force. Or each blade is offset to a closed position and sucks a flow path establishing a pressure difference, and each of the blades 4 can be exposed to a passing flow of air such that when the person sucks on the outlet, the passage of air The impact moves 'inward on the outer surface of the blade'. However, it is preferable that a blade 戌 each blade is supported by an elastic film. The elastic film establishes a chamber - in which the two vanes are mounted and opens or otherwise seals the opening to face the atmospheric pressure of the film on the opposite side of the vane. When the user sucks on the outlet, it establishes a negative pressure in the chamber to move the blade and the film contracts to allow this action. This provides a very efficient mechanism for transmitting suction force to the blade. Preferably, the deformable tube is a nozzle which is also integrally provided with an outlet orifice which is the narrowest portion of the flow path. In this case, preferably, the nozzle has an outwardly projecting flange-like flange at its upstream end which conforms to the lower end of an adjacent portion of the flow path. [Embodiment] A modification of the mouth valve The present invention relates to the use of a breath-initiating cigarette, and only this aspect of the invention will be specifically described herein. For details of the structure of the cigarette device and its refilling mechanism, please refer to 2009/001078. The first example of the inhaler according to the present invention is shown in Figures 3 through 3. The device has a housing 1 which is comprised of a main base 2 and an inclusive article 3 as shown in Figure 1. This is held in place by the label 4. In the housing, there is a reservoir 5 containing a respirable mixture. This is preferably pressurized, but it can also be operated in conjunction with a non-pressurized reservoir in conjunction with a Venturi nozzle to create an enhanced suction force on the trap or to contain an easy temperature at room temperature. An unpressurized reservoir of volatile material. It can be refilled through the fill valve 6 as described in w〇 2009/001082, or the device can be a disposable device, or can be arranged such that the reservoir 5 is a replaceable component. The breath actuating valve 7 is located between an outlet end 8 and the reservoir 5. The breathing activation valve is arranged such that when a user is inhaling at the outlet end 8, the breathing activation valve 7 is opened to allow the inhalable mixture from the reservoir 5 to be ingested. The housing at the outlet end has two holes. The first of these holes is a suction hole 9 which communicates with a chamber 1 and will be described in more detail below, and the second is an exit hole, from which the inhalable mixture is dispensed, and also The following is a more detailed description. As is apparent from Fig. 3, the exit holes 11 are provided on a separate component 丨2. An exit path 13 is defined between the reservoir 5 and the exit aperture i i . 10 201231103 The part of the exit path is provided by the deformable tubular element μ. The tubular member is moved between the closed position shown in Fig. 2 and the open position shown in Fig. 2 by the mechanism which will now be described. This mechanism includes a hinged blade 15 and a membrane crucible. The hub, the fixed vane has a hub i7 at the end closest to the outlet end 8, and a central reinforcing rib which is gradually smaller along the length of the outlet end. Around the midpoint, the vane 15 is provided with a recess 19 for receiving a spring 20 which biases the vane into the closed position shown in Fig. i. A sheet is attached below the recess 19 and has a triangular cross-section that is configured to impart a force from the blade 15 through a narrow area to the tube 14. The blade 15 is selected by a diaphragm 16 which is sealed to the housing at its end m. This seals the chamber 1 instead of sealing the suction holes 9. The lower side 24 of the membrane 16 is opened to the A gas pressure, and the material passes through a leak path present in the casing 1 which is not shown in the drawings as it extends around the outlet path 1 and is therefore not shown in the drawings. While a user sucks on the outlet end 8 of a device in the configuration shown in Fig. 1, the suction force is transmitted through the hole to the cavity through the suction hole 9, thereby reducing the pressure in the chamber. This causes the blade to be lifted to the position shown in Fig. 2 with respect to the action of the spring 20' to deform the diaphragm into the configuration shown in Fig. 2, and lift the blade 21 to allow the deformable tube to open, thereby The inhalable mixture from the reservoir 5 is allowed to pass along the outlet path 13 through the deformable tube 14 and out through the outlet opening 11. The degree of sucking applied by the user will determine the limit of the movement of the blade 201231103 15 and thus determine the amount of mixture received by the user. When the user stops sucking, atmospheric pressure will return to the chamber 10 through the suction hole 9, and the spring 20 returns the blade to the position of Fig. 1, so that the clamp tube 14 is closed. A second example of an inhaler is shown in Figures 4 through 6. This example also provides a deformable tube 14, a reservoir 5 and an outlet end 8, but the mechanism is slightly different. In the closed position of Fig. 4, the deformable tube is clamped between a pair of cymbals 30 of a spring clip 31. This clip 31 is shown shifted to the first position in Figure 4. The inhaler has an outlet opening 32 through which the flow path is completed from the reservoir 5 through the deformable tube 14 through the outlet aperture 32 and the plurality of suction apertures 3 3, the plurality of suction apertures providing suction to an internal chamber 34. . In this example, there is a pair of hingedly fixed vanes 35 extending longitudinally along opposite sides of the device. Each of the blades is coupled to an L-shaped bracket 36, one of which is shown in Figure 6. The L-shaped bracket extends into the respective crotch panel 30 and is effectively inwardly accessible to the opposite side of the deformable tube 因 for reasons explained below. The length-supply outlet holes 37 are in the casing 1, and each of the holes is used for each blade. When a user sucks at the outlet end 8, the suction force draws air through the inlet aperture 37 into the chamber 34 via the suction aperture 34, thereby applying an inward pressure to the blade 35. Due to the inward pressure, the f-plate is rotated inward to the position shown in Fig. 5. The L-shaped bracket 36 means that the downward movement of the upper blade 35 moves the lower jaw 30 downward, and the upward movement of the lower blade 35 moves the upper jaw 30 downward, as shown by 12 201231103 in Fig. 5 The deformable tube 14 is opened to dispense the inhalable mixture. When the absorbing force is removed, the pressure difference across the blade 4 35 is removed and the restoring force of the spring clip 31 returns the cymbal 30 to the position shown in Figure 4. An alternative arrangement of a deformable tubular member, blade 18, film 16 and other components will now be described with reference to Figure 7 broadly with reference to the same as illustrated in the previous examples. The main difference in this example is the configuration of the deformable tubular member 14, and such differences are fully explained below. Essentially, the hole u previously in the separate assembly is now integrated into the tubular member 14' as the hole 11'. This and Gugan + this has some additional benefits. First, by replacing two components with a single component, the overall space required for the path is reduced. This allows for an increase in the size of other items such as the blade 15 and the film 16. This in turn increases the sensitivity of the device as it more efficiently converts the respiratory force of ^ into the action of opening the flow path. This is important for the use of damaged lung function. Secondly, the manufacture of the device by eliminating the need for the tubular article 14 and the opening between the discs having the φ, η "μ negative holes 11 can be simplified. And ice in addition to this may eliminate possible leakage of this interface. Moreover, the manner in which the orifice disk 14 is sealed to the outlet path 13 in the upstream of the square is also modified. At the end of the tubular member 14, an outwardly projecting annular flange 40 is provided.舲 3 people + person, this will be in the upper end of the exit path 13. This provides a more reliable sealing arrangement than the tubular member 14 in place. As a result, 'the new mouth mouth is crying, it can contain a pressurized composition and there is no leakage for a longer period of time. Weishan Yiqiu thus increases the stability of the composition in the device and only for a longer period of time. Also maintain a relatively large capacity. 13 201231103 The tubular member 14, which may be of different thickness in a particular portion, is immediately adjacent to the tenon 4Λ ^ 叩. The h stresses a# % , p 苴_ at the nozzle wall downstream of the edge 4〇 are the largest. However, for the middle section of the tubular article 14, ', 1 piece 21 sealed tubular element, a material of reduced thickness can be used to allow for easier clamping action. The brother & good article '#piece 14' has a shore hardness between 2〇A and 8〇a, optimally 30A to 40A. For its P injury, the wall can be 〇5 mm thick and can be 0.18 rn m Ji / -Λ* in its thinnest part, ~ delivers the best performance on the inhaler for delivering the spray to the lungs The system, the σ hole u is preferably between G l _ and 5 1111 X1 wide, but preferably 0.2 to 0 3 mm and most preferably 〇 2 mm wide. The internal passageway in the tubular article 14' remote from the exit aperture u is preferably " 0.2 mm and 0.6 mm wide, preferably between 〇·3 mm and 〇·5 mm and optimally 0.4 mm. . BRIEF DESCRIPTION OF THE DRAWINGS An example of an inhaler according to the present invention will now be described with reference to the accompanying drawings, wherein: FIG. 1 is a partition of a first inhaler in a closed position via a perspective view; Figure 1 is a similar view in the open position; Figure 3 is an unfolded perspective view of the inhaler of Figures 1 and 2; Figure 4 is a second inhaler in the closed position via a perspective view 14 201231103 a cross-section; Figure 5 is a similar view in the open position; and Figure 6 is a perspective view from the outlet end of the second example showing the removal of the outer casing to show the clamping mechanism; and Figure 7 A section of an alternative arrangement of deformable tubular elements. [Main component symbol description] 1 Housing 17 Hub 2 Main base 18 Central reinforcing rib 3 Inclusion object 19 Groove 4 Label 20 Spring 5 Reservoir 21 Bractle 6 Filling valve 22 End 7 Breathing start valve 23 End 8 Outlet end 24 Lower side 9 suction B hole 25 hole 10 chamber 30 11 11 outlet hole 31 spring clamp 12 separate assembly 32 outlet hole 13 flow path 33 suction hole 14 deformable tube 34 internal chamber 15 blade 35 blade 16 film 36 L Bracket 15 201231103 37 Outlet hole 40 annular flange 16