TW201138951A - Continuous reaction micro-reactor - Google Patents

Abstract

A continuous reaction micro-reactor of modular structure comprises, arranged along a back-to-front stacking axis thereof, a first frame means, a reaction unit, and a second frame means, wherein said reaction unit comprises a process fluid channel system for continuous reaction of a plurality of feeds or reactants flowing into said reaction unit to form at least one product flowing out of said reaction unit, and a heat exchange fluid channel system for adjusting the temperature environment of said process fluid channel system, said first and second frame means are each formed as a flange, and said first and second frame means are alpressed towards each other by a plurality of tensioning means arranged along and within an outer circumference of said first and second frame means and enclosing said reaction unit.

Description

201138951 VI. Description of the Invention: [Technical Field to Be Invented by the Invention] The present invention relates to a microreactor for a continuous reaction of a modular structure, in particular, a microreactor for a continuous reaction. - [Prior Art] In the continuous reaction technique, a plurality of feeds or reactants are continuously flowed into the reactor or the microreactor, where a chemical reaction is carried out to form a continuously flowing product. A process fluid channel system is provided within the reactor that collects, mixes, and vortexes a plurality of feeds that are placed in an optimized reaction environment (particularly characteristic temperature conditions) to effect a chemical reaction. The process fluid channel system can be divided into at least one turbulent mixing zone suitably arranged in series and at least one base laminar stagnation zone. For the case of more than one mixing zone and/or retention zone, they are joined in an appropriate manner. For the well-known temperature conditions, a heat exchange system, such as a heat exchange system in the form of a channel, is usually integrated. Microreactors of the above type are disclosed, for example, in European Patent EP 1 839 739 A1, which is a modular microreactor comprising a plurality of process modules and heat exchange modules configured to form a stack. The process module forms a large and long flow channel system by adding external connections of individual subsystems, and due to the heat exchange module, the chemical substances (reactants, products) flowing into the flow channel system can be realized step by step. Heating or cooling (this paragraph uses the terminology used in European Patent EP 1 839 739 A1, the meaning of which is not always equivalent to the term in this article). The development of such a reactor is a complicated task, and even if it cannot be solved today, it is still necessary to solve the problem by computer analogy, and additional experimental research is needed to advance the field. 201138951 [Invention] It is an object of the present invention to provide a continuous reaction. The microreaction benefit of its laboratory-scale microreactor for in-situ studies of continuous reaction techniques allows researchers to understand the fluid dynamics involved more deeply, which can then be scaled up to industrial scale. This goal can be achieved by applying the features of Patent Scope 1. The present invention (the scope of the patent application) relates to a microreactor for continuous reaction. The crucible reactor (4) has a module structure, and the stacking shaft from the back to the front includes a first frame device, a reaction unit, and a second frame. Apparatus, wherein (b) the reaction unit comprises a process fluid channel system for continuous reaction of a plurality of feeds or reactants flowing into the reaction unit to form at least one product of the reaction unit, and including a heat exchange fluid a channel system for regulating a temperature environment of the process fluid channel system, (C) the first and second frame devices each forming a flange, and the first and second frame devices are passed through the plurality of first and second The tensioning devices that are peripherally and in the outer periphery of the two frame devices are pressed against each other and encapsulate the reaction unit (see Fig. 1 for a schematic view of the subject matter defined in Patent Application No. 1). Notes to (a). The modularity of the microreactor of the present invention means that all structural components (each of the flange and the reaction unit) can be replaced, so that various technical problems can be examined and solved. In this regard, for example, the ruthenium unit can be replaced by another different type and/or complexity of the process fluid channel system and/or the hot parent fluid exchange channel system to operate different chemical reactions or to have different physical properties (viscosity The feed of the properties, temperature and/or pressure dynamics, Reynolds number, etc. flows into the reaction unit. The term "from the back to the front, defines the back and front surfaces of each element or body forming the microreactor. In addition, the term "flange," should be understood as the base 201138951. The connection or fastening means in the vertical plane of the front axis and centered on the axis, whereby the rear-to-front axis can be regarded as the axis of symmetry. Furthermore, the flange has a circular shape or a circle Circumferential shape (the inner and outer circumferences may be, for example, square or rectangular; in this case, the corners may be circular or non-circular). Notes to (b): For the process fluid channel system and the heat exchange The spatial relationship between the body passage systems or the first and second frame means is not limited in principle as long as the heat exchange between them is sufficient to provide a chemical reaction between the various materials or reactants (ie, various chemistries) The material is produced in the micro-machine within the 3 Hz process fluid. The channel system interacts with the desired temperature environment. However, one of the channel systems is preferably in plane A, and the other channel system extends in plane B, among them The face A and the plane B are parallel to each other. More preferably, the channel system is at least partially formed uniformly to optimize heat transfer. The channel system can be produced, for example, by producing a reaction unit in a suitable casting technique. Advantageously, on the side of the reaction unit Providing respective inlet and outlet ends as shown in Figure 1. Note to (c): According to the invention, the space in which the reaction unit is arranged is defined (by the flange-like first and second frame means and by joining the The plane defined by the axes of two adjacent ones of the plurality of fastening devices of the second frame device and the second frame device are defined.) Advantageously, as shown in the figure, the compacting device is equidistantly arranged and incomplete Encapsulating or encasing the reaction unit to allow access to the side surface of the reaction unit from outside the microreactor, thereby establishing the necessary connection between the reaction unit and the external unit (fluid supply unit, pump, measuring device, etc.) Preferably, the inlet and outlet ends form an interface between the flexible outer conduit system (eg, the outer unit) and the process fluid channel system and/or heat Exchange fluid channel system arranged in the space, from

Second S 5 201138951 provides optimum mechanical protection for the reaction unit. According to the invention, the fastening means can be arranged along the outer circumference of the first and second frame means and in the outer circumference. That is, the first and second frame means, which are primarily mechanically protected from all other components, form the largest extension of the microreactor of the present invention in a plane perpendicular to the stacking axis. In summary, the microreactor of the present invention has three main advantages: (1) it is a modular design, (2) its reaction unit is mechanically protected by the first and second frame devices and the fastening device, and (3) The process fluid and heat exchange fluid passage system can be easily accessed from the outside. According to a preferred embodiment of the invention (patent 2), the reaction unit comprises a process and heat exchange module, and a cover plate is sandwiched between the process and the heat exchange module and the second frame device. First, as described above, the modularization of the present invention means that each of the process and heat exchange modules and the cover plate can be replaced individually. In addition, the cover acts as a seal to seal the process fluid channel system that forms the process and the front surface of the heat exchange module. That is, without the cover, the channels forming the process fluid channel system are open grooves of different thicknesses and/or depths that can be easily formed by some micro-processing techniques such as milling. Then, the opening groove can be liquid-tightly covered and sealed by a cover plate, leaving various inlets and outlets of the feed and the product on the side surface of the reaction unit. According to a preferred embodiment of the present invention (patent scope 3), the process and heat exchange module comprises a plate-like sub-module, a process sub-module and a heat exchange sub-module, and the patent application scope is defined in the factory and the second The modular concept of the present invention. For the manufacture and sealing of the corresponding channel system, the combination of the cover plate and the process sub-module corresponds to a combination of the process sub-module and the heat exchange sub-module; both the process fluid channel system and the heat exchange fluid channel system Facing the 201138951 second frame device, it is covered by the sealing of the rear surface of the adjacent module/board directly in front of it. - According to a preferred embodiment of the invention (patent claim 4), the heat exchange module and the first frame means are made of one part. This feature at first glances out of this modular concept because the functions of the two structural components are integrated into a single component. However, as long as the channels of the heat exchange fluid channel system are properly designed, it is possible for the same heat exchange fluid channel system to have multiple different process fluid channels. The system achieves sufficient heating and/or cooling effects. That is, the single "heat exchange sub-module - first frame device - integrated component" as defined in the application patent range 4 can be compatible with more than one process fluid channel system and the chemical reactions occurring therein. Therefore, at first glance, it is to reduce the modularity, and actually emphasizes the independent replacement of the sub-module/board. Further, manufacturing the heat exchange sub-module as a part and the first frame device reduces the manufacturing cost. According to a preferred embodiment of the present invention (patent 5), the process and heat exchange module includes a plate-like process and a heat exchange sub-module and a second cover plate, thereby continuing the application as defined in claims 1 and 2. The modular concept of the invention. The structure defined in claim 3 (wherein the process and heat exchange module includes substantially equivalent sub-modules when provided) differs from the channel system on the front surface thereof in that the process and heat exchange module include (1) first A sub-module comprising both a process fluid channel system (forming its front surface) and a heat exchange fluid channel system (forming its rear surface), and (ii) a second cover. The advantage is that any process and heat exchange sub-module can be designed to be the two most suitable

, S channel system. That is, in practice, the particular chemical reaction to be studied by the microreactor of the present invention requires a specific type of process fluid channel system to achieve optimal results, which in turn requires a specific type of heat transfer for achieving optimal results 7 201138951 Fluid exchange channel system. With the structure of the present invention, the selection of the process fluid channel system automatically provides an optimal heat exchange fluid channel system. According to a preferred embodiment of the present invention (patent scope 6), the process and heat exchange sub-module are further divided into a plate-like body, including a first sub-module body of the process fluid channel system, including the heat Exchange the second sub-module body of the fluid channel system. Therefore, subdividing into smaller "main" entities (ie, regardless of the components such as the entrance and exit) are: reaction unit - module - sub-module - sub-. - . . . According to the invention, the reaction unit is divided into four main entities, or the microreactor is divided into six main entities. It should be noted that the entity can also be grouped in different ways. That is, after the heat exchange fluid channel system is prepared, for example, the heat exchange sub-module body can be connected to the second cover plate to form a second heat exchange module (corresponding to the heat exchange module defined in claim 3, but Has a closed channel system that does not require additional surfaces to be sealed). According to a preferred embodiment of the invention (patent claim 7), the second cover and the first frame means are made of one part. Please refer to the above description of Patent Application No. 4 here. In accordance with a preferred embodiment of the invention (patent claim 8), the second frame device is configured such that the process fluid channel system can be viewed through a transparent cover. Such a review allows in situ observation of the flow characteristics of the feed, which continuously flows into the reactor to chemically react therein to form a mixture comprising products that continuously flow out of the reactor, and may also be in the microreactor at predetermined times The sediment is evaluated after the segment is "closed". The charge can be liquid or gas independently of each other, depending only on the reaction being faced. The flow of the feed (especially through the mixing zone of the process fluid channel system) is a mixed flow and depends on various parameters such as its viscosity (depending on the temperature experienced), flow rate (for the process) The specific geometry of the fluid passage (shape 201138951, size), depending on the inlet pressure), the geometry, the reaction kinetics of the feed, etc., is usually preferably observed in a computer analogy, or the computer analogy is first input Experimental data obtained by this method. Therefore, the choice of the flow of the chemical (feed/reactant and product) can be observed in the design of the process fluid channel system as an invaluable advantage. The cover of this aspect of the invention may be completely transparent, made of, for example, glass or plastic, or have portions of such materials that are suitably aligned. Advantageously, the colorless charge can be dyed to enable observation of the mixing process. Preferably, a chemical species that does not react with the feed, which exhibits a color change indicative of its temperature, can be added. For example, the pH indicator and neutralization reaction can indicate a mixing process along the length of the channel. In addition to visual inspection, information on the processes occurring in the process module (UV, IR, Raman) can be obtained by suitable instruments such as spectrometers or/and various filters. According to a preferred embodiment of the invention (patent claim 9), the second frame means has a window allowing said viewing. The window can have any suitable shape, primarily circular or rectangular, and ideally centered on the stacking axis. According to a preferred embodiment of the invention (patent claim 10), the cover is not transparent, but may be configured to allow external fluid connection through the second frame means to the read cover to act as the process fluid passage System fluid inlet device. This has the advantage that it is possible to incorporate additional feed into the process fluid channel system through the front surface of the cover plate such that the portion of the combined charge is not limited by the side surface of the reaction unit. In addition, the passage connecting the process fluid passage system to the outer portion can be shorter. According to a preferred embodiment of the invention (patent 11), the surface of the cover plate directly covering the process fluid channel system is provided with a catalytic coating. The catalytic coating can be applied only to the area of the cover that is in contact with the fluid in the process fluid channel system. As a modification of the catalytic coating prepared from a single catalytic material, the catalytic coating may be made of different catalytic materials depending on the catalytic coating of the cover plate and the reaction unit in relation to the process fluid channel system s position. Alternatively or additionally, the catalytic material may be inserted directly into the reaction channel in the form of a microsphere or a Raschig ring. According to a preferred embodiment of the present invention (patent claim 12, the process fluid channel system has a plurality of primary inlet ports for a plurality of primary charge flows into the process module, and the plurality of primary inlets in a chemical flow direction) After the end, at least one secondary inlet end of at least one secondary feed stream flowing into the process module. Thus, a complex chemical reaction can be observed along the process fluid channel system, wherein, for example, by mixing two primary The substance initiates a first reaction to form a first (intermediate) product, then a second feed stream is added and mixed with the first (intermediate) product to form a second intermediate product, etc. Each time a second charge is added, advantageously Mixing with the corresponding product formed previously. Alternatively, as disclosed in European Patent No. EP 1 839 739 A1, the second charge added each time reacts with a certain amount of the first charge by the multiple injection module. According to a preferred embodiment of the invention (Application No. 13), the primary and/or secondary inlet ends are arranged on the side surface and/or the front and rear surfaces of the reaction unit. The arrangement of the mouth ends on the side surfaces enables a compact and space-saving design that is insufficient to supply the feed at each location in the process fluid channel system, particularly in constructing the structural elements of the process fluid channel system ( When there is less space between the windings, this condition can be changed by arranging the inlet ends on the front and/or rear surfaces of the reaction unit. Ideally, through a lower density process fluid channel system (where the supply or feed) 10 201138951 The channel can be established to have either of the advantages of being connected to the process fluid channel system. In accordance with a preferred embodiment of the invention (patent scope i6), the 帛- and second frame skirts of the ruthenium reaction microreactor are respectively There are second and second positioning means defining the position of the heat exchange module and the process module relative to the (four) stacking axis. Since these positions are set, according to the invention: the embodiments (patent scope 17) are respectively formed as The recesses on the surface of the first and second frame devices, the module for constructing the microreactor can be accurately and clearly also =:= will be replaced in the modification The elements each have the same external dimensions as the recessed inner dimensions formed in the respective framed wood device, and are assembled and brightened relative to each other. < As part of the patent application scope f 1 BS 1 , the main call is as noted above The structure of the main aspect of the invention is shown in Fig. 18. My [Embodiment] will be described in detail with reference to the specific embodiment of the invention. The assembly continuous reaction of the microinvention first embodiment According to the first perspective, according to the 1st, the microreactor: two: stacking axis s · (where the direction from the back to the front two R:: the arrow of the page part) - the first frame device 100, anti-li... U and the second frame device. The first, (10), and the sub-clear are flanges, and the bolts 206 are extended by the four bolts to extend through the through holes in the second frame assembly i_ The side grain hole 2G5, which is divided into the outer circumference of the fan and the outer circumference of the fan, is in the outer circumference, and the axis diagram of each two adjacent bolts 206 is not the same, thereby obtaining a total a 201138951 four planes with the first and second frame devices 100, 200 Set or define the spatial arrangement of the reaction unit RU. Specifically, by clarifying the pressing force, the first frame device 100 presses the reaction unit RU from below by the bolt 206, and the second frame device 200 presses the reaction unit RU from above by the bolt 206. The reaction unit RU comprises a process fluid channel system for continuous reaction of various feeds or reactants flowing into the reaction unit RU to form at least one product flowing out of the reaction unit RU, and comprising a heat exchange fluid channel system, Used to adjust the temperature of the process fluid channel system. Although neither of the channel systems is shown in Figure 1, the inlet and outlet openings forming the respective ends of the feed and product channel systems are visible on the surface side of the reaction unit RU. The inlet and outlet openings may have inlet and outlet ends which in turn are connected to the appropriate (flexible or non-flexible) connection of the reaction unit RU to the external unit (feeding supply unit, pump, measuring device, etc.) between the respective two bolts 206 )catheter. Fig. 2A shows a schematic exploded perspective view of the continuous reaction 'microreactor 10 according to the second embodiment of the present invention. In the micro-reactor 10 of the second embodiment, the reaction unit RU of the first embodiment is divided into a heat exchange sub-module 400, a process sub-module 300, and a cover plate 500 along the rear-to-front stacking axis S. Both the sub-modules 300, 400 and the cover plate 500 are fluid-tightly sandwiched between the first and second frame devices 1 and 200. The first and second frame devices 100, 200 are formed as rectangular flanges and respectively include four threaded holes 104 and through holes 204 that surround the stacking axis S and are equidistantly spaced therefrom and receive the bolts 206 (see Fig. 1), 'The thread is used to press the sub-modules 300 and 400 and the cover plate 5_00 to form a liquid-tight entity referred to above as the reaction unit RU. The second frame device 200 has a rectangular opening 203 centered on the stacking axis S and allows the process fluid channel system 304 and the external unit formed in the front surface of the process sub-module 300 to be connected through the holes 502 12 201138951. The first frame device 100 has a rectangular recess 106 in which the heat exchange sub-module 400 is attached. The recess 106 can be used as a positioning device of the present invention and, alternatively, can be formed or specifically formed in the second frame device 200. In addition, the first and second frame devices 100, 200 may be formed of any suitable material (for example, Ming, Wuzheng, etc.), which can break the necessity of the microreactor 10. Dimensional stability. As shown in FIG. 2A, the process sub-module 300 and the heat exchange sub-module 400 are each plate-shaped and include annular grooves 302 and 402, respectively, for accommodating corresponding 〇-shaped seals (not shown), Thus, in the microreactor 1 〇 assembly state, the process sub-module 300 compresses the seal contained in the groove 402 of the heat exchange sub-module 400 to form the heat provided in the heat exchange sub-module 400. The sealed compartment of the fluid channel system 404 is exchanged. Similarly, in the assembled state of the microreactor 10, the cover plate 500 compresses the seal contained in the slot 302 of the process sub-module 300 to form a process fluid channel system provided in the process sub-module 300. 304 sealed compartment. It should be noted that the Ο-ring seal is only a safety measure for protecting the process sub-cylinder 300 and the heat exchange sub-module 400 from leakage, and the cover plate 500 (rear surface) ^ and the process sub-module The contact surface of the group 300 (front surface) and the contact surface of the process sub-module 300 (rear surface) and the heat exchange sub-module 400 (front surface) each have a roughness depth equal to or less than 1 μm. Thus, the cover plate 500 and the process sub-module 300 prevent fluids flowing into the respective channel systems they cover from leaving the channel system ("spill") only by pressure contact; no further sealing is required. It should be further noted that for the heat exchange sub-module 400 in which the chemical reaction 13 201138951 has not occurred, the corresponding contact surface need not have the above-described high quality, since whether part of the heat exchange fluid "overflows" from one part of the heat exchange liquid passage to the other part actually It doesn't matter. In the first embodiment shown in FIG. 2A, in the assembled state of the microreactor 10, the process sub-module 300 and the heat exchange sub-module 400 are in direct thermal contact. Specifically, to achieve optimal heat transfer, the loop line of the process fluid channel system 304 of the process sub-module 300 is aligned with the heat exchange fluid channel system 404 of the heat exchange sub-module 400. As can be seen from FIG. 2A, both the heat exchange fluid channel system 404 provided in the heat exchange sub-module 400 and the process fluid channel system 304 provided in the process sub-module 300 form a meandering groove. Thereby extending within the respective grooves 302, 402. In addition, the heat exchange sub-module 400 and the process sub-module 300 each have a bore 3 16 , 416 that is matched to each other in the stacking direction S to accommodate a bolt (not shown) that displaces the heat in a detachable and compact manner. The exchange sub-module 400 and the process sub-module 300 are connected to each other. Therefore, the connected heat exchange sub-module 400 and the process sub-module 300 can be regarded as forming units sandwiched between the first frame device 100 and the cover plate 500 attached to the second frame device 200. In the first embodiment shown in FIG. 2A, the heat exchange sub-module 400 is arranged such that the heat exchange fluid channel system 404 incorporated therein faces and is sealed by the process sub-module 300, and The process sub-modules 3 00 are arranged such that the process fluid channel system 304 incorporated therein faces and is sealed by the cover plate 500. _ Figure 2B shows an alternative structure consistent with the structure of Figure 2A except for the cover plate 500 and the second frame device 200. In the structure shown in Fig. 2B, the cover is formed of a transparent material (e.g., glass), and the opening 203 14 201138951

The shape of the cover plate 500 (rectangular in Fig. 2A and fitting with each other) is circular in the 2B drawing and is fitted to each other. This allows the process (flow, mixing, reaction) occurring in the process fluid channel system 304 of the process sub-module 300 to be observed. It should be noted that the circular shape of the transparent cover plate 500 advantageously reduces the mechanical stress experienced by the transparent cover plate 500 since an extremely high working pressure is applied to the charge flowing into the process fluid passage system. For the rectangular cover 500 of Fig. 2A, both the thickness and the material thereof can be more freely selected in accordance with • · · . . . . As described above, the shape of the opening 203 in the second frame device is not limited by the high pressure. 3A and 3B are schematic exploded perspective views showing two variants of the continuous reaction microreactor according to the third embodiment of the present invention. The difference between the 3A and 3B is also that the former cover 500 is rectangular and opaque, while the latter cover 500 is circular and transparent. The remaining details are the same as those shown in Figures 2A and 2B, respectively. As shown in Figures 3A and 3B, the process sub-module 300 of the 2A and 2B and the heat exchange sub-module 4000 are combined to form the process and heat exchange sub-module 700. In other words (again with reference to the second embodiment), (a) the heat exchange fluid channel system 404 is moved from the front surface of the heat exchange sub-module 400 to the rear surface of the process sub-module 300, and the heat exchanger The module 400 is converted into a second cover 800 as shown in Figure 3A. That is, the total number of submodules and boards does not change. 4A and 4B are schematic exploded perspective views showing two variants of the continuous reaction microreactor according to the fourth embodiment of the present invention. The fourth embodiment is different from the third embodiment in that (the third embodiment is referred to), the process and the heat exchange sub-module are divided into a first plate-shaped sub-module body including the process fluid channel system 304, And a second plate-like sub-module body including the heat exchange fluid passage 15 201138951 channel system 304. In other words (again with reference to the second embodiment) '(a) the heat exchange fluid passage system 4〇4 is moved from the front surface of the heat exchange group 400 to the rear surface of the second plate-like sub-module body, = second The plate-shaped sub-module body is inserted between the heat exchange sub-module 4 and the process sub-module 300. More specifically shown in Figure 5, the process fluid channel system is divided into a parent-coupled turbulent mixing zone 3〇6 and a base laminar retention zone. A plurality of primary inlet ends 31 1 形成 are formed on the inlet side of the joint, and an outlet end 314 is formed on the outlet side of the joint. Between the inlet and outlet sides of the joint, particularly at the junction of the mixing zone and the retentate zone, a secondary inlet end M2 is provided, from which secondary feed (chemicals) can thereby be introduced into the process fluid channel system. As shown in Fig. 14, the inlet ends 31, 312 and the outlet end 314 are formed as openings in the side surface of the reaction unit RU, and according to an alternative configuration (process sub-module 3001), the inlet end and the outlet end 3 14 is arranged in the annular groove 3 〇2. Figures 6-15 illustrate a variation of the process fluid channel system of the process sub-module of the present invention shown in Figure 5, wherein the inlet and outlet ends are arranged in the recess 302 and open to each of the changes. Front or rear surface-side (the upper or lower surface in Figure # and the convex plane in Figures 6 and 15), the groove 302 divides the front surface of the process module into an inner region and an outer region The process fluid channel system 304 is arranged in the inner region, and the outer 4 region is arranged to fix the process die, and the bore 316 of the heat exchange sub-module 400. The process fluid channel system 3 shown in FIGS. 6-8 and U_15 each includes a plurality of primary inlet ends 3K) located at the process fluid channel system 3Q4W (eg, "left side in the figure"), Process fluid channel system 16 201138951 304 is an outlet end 3 14 (eg, right side in FIG. 6), and one or more secondary inlet ends 312 between the primary inlet end 310 and the outlet end 314. Thus, in terms of overall flow direction, such as from left to right, the β-process fluid channel system 304 can be considered to be divided into mixing sections, (1 = 4 in Figure 6,) each including at least one turbulent mixing zone. 3〇6 and/or at least one laminar retention zone 308, wherein each outlet of the segment Ai and the segment, the entrance of the +1 form a secondary inlet end 312. Thus, between segments A and Ai At the junction, the reactor & can be further added to the intermediate product formed by the chemical reaction in the segment Ai. For example, the process module 300 of Figure 6 includes two primary inlet ends 3 1 0 ' It is used for the reaction of the reagent core and R2, Rl and R2 are reacted in the segmentation 得到ι to obtain the first - intermediate Product P]. The first-second inlet end 312' connected to the segment A! and A2 may further add a reactant & to generate a second intermediate product P2, and so on until the (final) product & The outlet end 314 flows out of the process module 300*. The process module 300 shown in Figures 9 and 10 differs from the sixth and eighth figures in that three independent process fluid channel systems 304_i to 3 04-3 are integrated. There are two inlet ends 31〇 and one outlet end respectively. This allows for a comparative study of different reactions or mixing effects. It should be noted that the second (7)l body channel system 304-1 has two mixing zones 306, and the process fluid Channel systems 304-2 and 304-3 each have only one mixing zone 3〇6 ^ Figure 17 exemplarily shows various typical mixer component structures f to f) 'respectively referred to as 1 contactor according to their appearance , γ_contactor, tangent, edging, sz_mixer, and B. Mixer. These structures can be identified by the variants shown in Figures 6-16. 17 201138951 In the following, various descriptions will be described in accordance with some of the figures. Specific details of the fluid channel system. Figure 8 shows Three different types of mixing zones 306 (from left to right): (1) longer followed by shorter tangent zones, straight LZ zones, and normal U-shaped SZ zones. In addition, some locations outside the flow channels are shown in Figure 8 as small. The bevel "3" indicates that the process fluid channel system is removed from the pure two-dimensional structure, i.e., has a slope in the corresponding channel, wherein the oblique direction corresponds to the orientation of the slope 320. Another detail is shown in Figure 10, Figure 304- Part 1. The left side of the mixing zone 306 includes a projection 322 that is located substantially in the middle of each of the four tangential mixers that make up the mixing zone. Similar protrusions are for example also shown in Figure 10. This protrusion 322 can enhance the vortex effect. The process module also displays the above bevel. It should be noted that the 3D structure of the above described process fluid channel system 304 can also be seen by the limitation and narrowing of the tangential mixer inlet channel, which is shown, for example, in Figure 13 and is missing from Figure 10. The combination is shown in the right side mixer in Fig. 15, wherein the mixer is combined into 2D-3D-2D-3D in the flow direction (from top to bottom inside the mixer). Figure 13 shows the use of a catalytic material in a so-called catalytic flow channel 318, i.e., the process fluid channel system 304, including, for example, a coating form on which a flowing reactant/product flows. The flow channel of the catalytic material. This means that the catalytic material is part of the process module body. Barrier 324 prevents the catalytic material from partially entering the process fluid channel system. It should also be noted that the inlet and outlet directions for entering and leaving the mixer, respectively, may be the same or different, resulting in different degrees of mixing. 18 201138951 Comparing Figures 6-1 5, it is apparent that the length, width, routing, alignment, etc. of the process fluid channel system 304 can be varied independently such that the process fluid channel system 304 can be adjusted optimally. Figures 16A and 16B are schematic perspective views of a fabricated microreactor according to the present invention, wherein Figure 16B shows an enlarged view of the process fluid channel system seen in Figure 6A via the second frame device. Specifically, Fig. 16B shows the structure shown in Fig. 5. It can be clearly seen that the flow channel system 304 includes a mixing zone 306, a stagnation zone 308, and a secondary inlet port 312. The primary inlet and outlet ends 3 10, 3 16 extend from the lower portion of Figure 16A, which connects the microreactor to a pump and a suitable product vessel, respectively. For the materials used in the first and second embodiments, it should be noted that the process module typically employs a rigid material for dimensional stability, and the material used for the heat exchange module may be rigid or malleable, preferably stainless steel. Examples of rigid materials used in process modules are: stainless steel, Hastelloy and other nickel alloys, cranes, groups, Chin, pottery, graphite, sintered quartz m (fuzzy, translucent or colored), heat exchange modules Examples of ductile materials used in the group are polymers, Ming alloys, copper, copper alloys, silver and silver alloys, preferably aluminum or tantalum alloys. Examples of rigid materials used in heat exchange transverse groups are stainless steel, Hastelloy, and other nickel alloys or ceramics. The material used for the transparent cover is preferably selected from the group consisting of polymers, vermiculite glass, quartz glass or fused silica. It should be noted that all surfaces, even the glass surface, should be ground to a thickness of 1 μιη on the surface of the surface. The schematic drawing of Fig. 18 shows the first to fourth embodiments and the corresponding drawings. In addition, in order to deepen the understanding of the basic request structure, some of the features defined in the claims are shown in the dashed box. Specifically: 19 201138951 ((it:: to the fourth shed represent the first to fourth embodiments respectively. In the art and heat application mode, the reaction unit includes a cover plate and a workway system, and c is a heat exchange fluid Channel system. 2 defined in 3, editing technology, E is the scope of patent application

For the application-patent; for the feature defined in the scope of patent application 5, G is the feature defined in the patent: Patent _ 6. As described in the above, although the embodiment of the present invention is used to limit the invention, the preferred embodiment of the invention is as disclosed above, and the present invention does not deviate from the present invention. The Hi and the money inside of the present invention can be used for various changes and refinements. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a schematic perspective view of a microreactor equipped with a continuous reaction according to a first embodiment of the present invention; FIG. 2A And FIG. 2B is a schematic exploded perspective view of two variants of the continuous reaction microreactor according to the second embodiment of the present invention; ^ FIG. 3 and FIG. 3 are microseries of the continuous reaction according to the third embodiment of the present invention. A schematic exploded perspective view of two variants of the reactor; Fig. 4 and Fig. 4 are schematic exploded perspective views of two variants of the microreactor of the continuous reaction according to the fourth embodiment of the present invention; A schematic perspective view of a module showing details of a particular type of process fluid channel system in accordance with the present invention; FIGS. 6-15 are variants of a process fluid channel system in accordance with the present invention; 20 201138951 弟16A and 16B are based Assembly microreactor of the invention

A perspective view of the core of FIG. 16B shows an enlarged view of the process fluid channel system as seen in the second frame device in FIG. 7; FIG. 17 is a schematic view of a typical mixer type; and a drawing of FIG. The main aspects of the invention as defined in the scope of the patent application are shown. [Description of main component symbols] 10 Microreaction of continuous reaction 100 First frame device 104 Threaded hole 106 Rectangular recess 200 Second frame device 203 Circular opening 204 Through hole 205 Threaded Holes 206 Bolts 300, 300, Process Sub-Module 302 Jade-Shaped Groove 304. Process Fluid Channel System 306 Mixing Zone 308 Retention Zone 310 Primary Inlet End 312 Secondary Undercut End 314 Outlet End 316 Drill Hole 21 201138951 318 Catalysis Flow channel 320 bevel 322 protrusion 324 barrier 400 heat exchange sub-module 402 annular groove 404 heat exchange fluid channel system 416 drilling 500 cover 502 600 cover 700 process and heat exchange sub-module 800 second cover. A , orientation of B 300 P product R reactant RU reaction unit S stacking axis 22

Claims (1)

201138951 VII. Patent application scope: 1. A continuous reaction microreactor comprising a first frame device, a reaction unit and a second frame device along its rear-to-front stacking axis, wherein: The reaction unit includes a process fluid channel system for continuous reaction of a plurality of feeds or reactants flowing into the reaction unit to form at least one product flowing out of the reaction unit, and including a heat exchange fluid passage. a system for adjusting the temperature environment of the process fluid channel system, - the first and second frame means are each formed as a flange, and - the first and second frames The apparatus is opposed to each other, presses and encloses the reaction unit by a plurality of tensioning devices arranged along the outer circumference of the first and second frame devices and in the outer periphery. 2. The continuous reactor microreactor of claim 1, wherein: - the reaction unit comprises a process and heat exchange module, and sandwiching between the process and heat exchange module and the second frame a cover plate between the devices, and - the process fluid channel system includes a microstructure forming the reaction surface of the process and heat exchange module, the process and heat exchange module being sealed by the cover plate to process the process fluid The way the channel system is directly covered. 3. The microreactor according to claim 2, wherein: the process and heat exchange module comprises a plate-shaped process sub-module, the front surface of which is the reaction table δΓ, and includes a plate-shaped heat exchange sub-module sandwiched between the process sub-module and the first frame device, and λ. 23 &lt;33; 201138951 - the heat exchange fluid channel system includes forming the heat exchanger a front surface of the module and a microstructure covered by the rear surface of the process sub-module in a manner to seal the heat exchange fluid channel system. 4. The continuous reaction microreactor of claim 3, wherein the heat exchange sub-module and the first frame device are made of one portion. 5. The continuous reaction of the invention as claimed in claim 2, wherein: - the process and heat exchange module comprises a plate-like process and a heat exchange sub-module, the front surface of which is the reaction surface a second cover plate sandwiched between the process and the heat exchange sub-module and the first frame device, and - the heat exchange fluid channel system includes a rear surface forming the heat exchange sub-module, And a microstructure covered by the second cover in a manner to seal the heat exchange fluid channel system. 6. The continuous reaction microreactor of claim 5, wherein the process and heat exchange sub-module are divided into a first portion including the process fluid channel system by a plane perpendicular to the stacking axis a plate-shaped sub-module body and a second plate-shaped sub-module body including the heat exchange channel system. 7. The continuous reaction microreactor of claim 5 or 6, wherein the second cover and the first frame means are made of one portion. 8. The continuous reaction microreactor of any one of claims 2-6, wherein the 'second frame device is configured such that the process stream can be viewed through the transparent cover艟Channel system. 9. The continuous reaction microreactor of claim 8, wherein the second frame device has an observation window that allows the viewing. </ RTI> </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; External fluid connection as a fluid inlet device for the process fluid channel system &quot; 11. The microreaction of the continuous reaction as described in one of claims 2-10, wherein the process fluid channel is directly covered The surface of the cover of the system carries a catalytic coating. 12. The microreaction benefit of the continuous reaction of any one of claims 2-11, wherein the reaction unit has a plurality of primary inlet ends for a plurality of primary feeds flowing into the process fluid channel system. And at least one secondary inlet end of the at least one secondary feed stream flowing into the process fluid channel system after the plurality of primary inlet ends in the flow direction. 13. The continuous reaction microreactor of claim 12, wherein the primary and/or secondary inlet ends are arranged on the reaction unit side surface and/or the front and back surfaces. A continuous reaction microreactor according to the above-mentioned item of the invention, wherein the process fluid channel system and/or the heat exchange fluid channel system are formed in a meandering manner. 15' The microreactor of the continuous reaction as described in the item [H4] of the patent application, wherein the process fluid channel system comprises at least one contiguously arranged along the flow direction of the primary charge flowing therethrough. Flow mixing zone and 'at least one base layer flow retention zone. The microreactor of the continuous reaction described in the above-mentioned claim, wherein the first and second frame devices respectively have first and second positioning means defining the reaction unit and the Stack the phase of the phase 25 201138951 to the position. U. The continuous reactor microreactor according to claim 16, wherein the first and second positioning devices 1 are formed on the surfaces of the first and second frame devices to face each other. Further, wherein the inner shape of the recess is the same as the outer peripheral shape of the corresponding side of the reaction unit. The recesses in which the first and second positioning means are formed in the microreaction of the continuous reaction described in the πth item of the patent application range are rectangular. 7 26