TW201130524A - Compositions and methods for disinfecting contact lenses - Google Patents

Abstract

The present invention relates to a hydrogen peroxide solution for disinfecting contact lenses. The hydrogen peroxide solution contains an effective amount of a homopolymer or copolymer of vinylpyrrolidone to an increased residual hydrogen peroxide concentration when in the presence of a catalyst, thereby prolonging the effective life of the solution and providing greater comfort to the weather.

Description

201130524 VI. INSTRUCTIONS OF THE INVENTION: TECHNICAL FIELD OF THE INVENTION The present invention generally relates to sterilization for medical devices and, in a preferred embodiment, the present invention relates to compositions for simultaneously cleaning and disinfecting contact lenses, Methods and objects. [Prior Art] Disinfection solutions used in contact lenses are well known in the art and the use of such glasses includes daily disinfection treatment. Flexible or soft contact lenses are typically made from self-polymerizing 2 polymers, and the bases of such glasses attract and retain the water that is commercially available in the plastic, thereby causing difficulties during cleaning and sterilization. The two most common methods of disinfecting contact lenses are multi-functional solutions (where single-solutions are used to disinfect, clean, and store glasses) and peroxygen-based systems. The multi-functional solution contains preservatives but the system based on hydrogen peroxide contains no preservatives. Hydrogen peroxide is an effective microbial disinfectant that kills pathogens by oxidation. Hydrogen peroxide system, specifically 3; hydrogen peroxide solution, appears as the preferred disinfectant for all types of day-and long-wearing hydrogel lenses. The main reason for its universality is its ability to quickly kill microbial contaminants and their residue-free properties. After sterilizing the lens with hydrogen peroxide, it can be converted into harmless and ocular (four) by-products such as 〇2 and water that are compatible with ocular physiology. See Krezanoski et al., "of Plus American Opt〇metric Ass〇ciati〇n", Vol. 59, Vol. 3, pp. 6193-197 (1988). In general, the hydrogen peroxide system comprises a disinfecting solution containing hydrogen peroxide, which is placed between the contact lens to be sterilized and held for the period of time I51304.doc 201130524. The hydrogen peroxide can (1) oxidize the vapor in the bacteria to a hypoxanthate or (2) decompose into nascent oxygen and a meridional group, thereby providing a bactericidal action. Following the necessary time of the stage, the hydrogen peroxide is purposefully deactivated, for example, with a platinum catalyst. After deactivation, the contact lens can be re-applied to the eye. A large number of patents are available for the hydrogen peroxide contact lens disinfection system. Refer to the following:

U.S. Patent No. 5,523, filed on Jan. No. No. No. Nos. However, all of the disclosed surfactants are present in amounts greater than % 1% and are incompatible with platinum catalyst disks typically used to deactivate hydrogen peroxide in eyeglass disinfection systems due to excessive material formation. A composition and method for disinfecting and cleaning contact lenses is taught by U.S. Patent No. 5,746,972, which includes a liquid medium containing hydrogen peroxide and a solid epoxy epoxide/ring having at least 70% by weight of polyethylene oxide. Oxypropane block copolymer surfactant. The hydrogen peroxide is degraded by the release of catalase into the solution and causes "a decrease in the amount of beads". ^, when using a catalyst to decompose hydrogen peroxide, the compositions cause excessive foam formation. A long-standing need in the contact lens industry to provide a convenient, but effective, contact lens care solution. There are two types of hydrogen peroxide contact lens disinfecting solutions and their systems: the step system and the two-step system include: firstly, the contact lens is immersed in hydrogen peroxide having a concentration of 6%.6% to 3%. In solution - for a period of time, during which time 'the concentration of hydrogen peroxide is almost constant, and secondly, soak the contact lens 151304.doc 201130524 into the catalysis = to neutralize the peroxidation gas remaining in the contact lens + step system has The contact lens is immersed in about 3% of the chlorine peroxide solution in the box of the setting dial for about 6 hours. After dip =, the concentration of residual hydrogen peroxide is reduced ^, ", ppm, more preferably - the contact lens is worn on the eye. Typically, a two-step radiant has a higher material efficiency than a "step" system because the former has a higher concentration of chlorine peroxide during the sterilization process. However, the -step system is more convenient than the two-step system and is popular in contact lenses (4). Therefore, it is advantageous to provide a peroxide contact lens that overcomes - or a plurality of such problems. SUMMARY OF THE INVENTION In the present invention, the present invention provides a contact lens for disinfecting contact lenses, which comprises an effective disinfecting amount of hydrogen peroxide and a homopolymer or copolymer of ethylene ketone. Wherein the homopolymer or copolymer of the ethylene base (4) is sufficient to provide a control/liquid mixture having the same composition relative to the homopolymer or copolymer which does not contain the ethyl acetate phase in the presence of the phase (4) medium. An amount of at least 20% of the excess cerium peroxide concentration is present; in an amount sufficient to enhance one or more buffers of the composition of about 6. 〇 to 8. 阳 of the cation, wherein the sigma has about 2 〇〇 to The osmotic pressure of about 45 〇 m〇sm/kg and the viscosity at which it is lowered to 5.0 centipoise. In another aspect, the present invention provides a method of disinfecting a contact lens comprising the steps of: (a) contacting a contact lens with an aqueous solution containing the following components: an effective disinfecting amount of k-hydrogen peroxide and a vinyl ratio a homopolymer or copolymer of each ketone, in which the ethylene group D is more than 17 homo- or homopolymers in the presence of the same catalyst in the presence of the same catalyst in 151304.doc 201130524 A control solution of the homopolymer or copolymer of the rancidinone having the same composition is sufficient to provide an amount to increase the residual hydrogen peroxide concentration by at least 20%; and in an amount sufficient to provide a composition of about 6.0 to 8. (H〇 One or more buffers, wherein the group has an osmotic pressure of from about 200 to about mo m〇sm/kg and a viscosity of from 2 to about 5.0 centipoise at 25°; and (b) by The hydrogen peroxide catalyzes the neutralization of water and oxygen to neutralize the hydrogen peroxide. These and other aspects of the present invention will become apparent from the following description of the preferred embodiments. Limiting the scope of the present invention, the material of the present invention is covered by the scope of the patent application Many modifications and adaptations of the present invention can be made without departing from the spirit and scope of the present disclosure. All technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. In general, the names and laboratory steps used in the text are well known and used. Known methods are used in such (4), such as those provided in the art and in various references. When provided in the singular form, the inventors also cover the plural form of the term. NAME AND ITS: The laboratory procedures described are well known and commonly used in the art. As used herein, unless otherwise indicated, the following terms shall be understood to have the following meanings of 151304.doc 201130524. The present invention relates to a solution of a homopolymer or a copolymer of hydrogen peroxide and ethylene (4) (d) wherein the homopolymer or copolymer of the ethyl ketone is not present in the presence of the same catalyst a control solution having the same composition of a homopolymer or copolymer of ethylene base bite sufficient to provide an amount of at least 20% increase in residual hydrogen peroxide concentration; and a solution for disinfecting and/or A method of preserving contact lenses, especially soft invisible glasses. The disinfecting solution of the present invention is effective against a wide range of microorganisms including, but not limited to, Staphylococcus aureus (5) A. sphaeroides, Serratia serrata (Serratia) Marcescens, white chanting, Fusarium solani. Disinfecting solutions are generally defined as a contact lens care product comprising one or more active ingredients (eg, antibacterial agents and/or preservatives). The concentration of the ingredients is sufficient to kill harmful microorganisms on the surface of the contact lens during the recommended minimum soaking time. The recommended minimum soaking time is included in the package insert for the disinfection solution. The solution of the present invention is recognized as a novelty for the care of contact lenses. The term "soft spectacles" means a spectacles having a proportion of hydrophilic repeating single 7G ' such that the water content of the spectacles is at least 2 〇 〇 / 在 during use. The term "soft contact lens" as used herein generally refers to a contact lens that can be easily bent under very small forces. Typically, soft contact lenses are formulated from polymers 151304.doc 201130524 having a specific ratio of repeating units derived from hydroxyethyl methacrylate and/or other hydrophilic monomers which are typically crosslinked by a crosslinking agent. Relatively known as 'hard contact lenses' (which cover only one part of the cornea of the eye), they are usually composed of poly(methacrylate) or the like crosslinked with ethylene glycol dimethyl acrylate. And conventional rigid gas permeable contact lenses (RGP) are typically composed of a monomer containing a more oxygen permeable material. The term "ophthalmological safety" with respect to a contact lens solution means that the contact lens treated with the solution is safe for direct placement on the eye without rinsing, ie the solution is in contact with the eye daily through the contact lens. It is safe and quite comfortable. The ophthalmically safe solution has compatibility with the eye and pH and includes substances and amounts thereof that are cytotoxic according to international ISO standards and u, s. FDA regulations. Solution "being compatible with the eyes" means that the species can be in close contact with the eye for a length of time, but does not significantly damage the eyes and does not cause significant discomfort to the user: the term "disinfecting solution" means one or more a microbial compound/valley solution, which can effectively reduce or - the series of materials "...present on contact lenses", ", can be immersed in a stimulating solution by using a specific inoculum of such microorganisms The contact lens after the solution is tested. As used herein, the term "disappearing, quenching, cold, and π 1 乂Τ is used for the disinfection solution, and the night can be used for storing the solution or "~ night can be different from the hidden (4) The possibility of daily mirroring. /r / No and storage The term "cleaning the object to be cleaned will be loosely held" means that the solution contains - or a plurality of concentrations sufficient for them =: glasses deposits and other contaminants are loosened ... ... shell removed active ingredients . Although it is not necessary for the cultivar 151304.do, 201130524, the user may wish to manually treat the 一U 00 solution (for example, 'Use the touch aid 5 1 - stir the solution to connect it to the glasses Solution. A solution for aiding reading (e.g., '-mechanical cleaning aids) for use in cleaning, chemical disinfection, storage of mirrors of the present invention is referred to herein as "multiple/pieces (such as contact lenses L π. 'liquids". These solutions can be referred to as “岌 I 谷 谷 谷 ” or “multi-functional solution packaging” Ο functional solution, system or packaging steps are called “ ° :. Use of multi-functional solution does not exclude the following possibilities: I's a poisoning scheme. A disinfectant 戋its ', two wearers, such as a wearer who is particularly sensitive to wearing a == agent, may prefer to use another solution (such as sterile saline) ... contact lens. The term "multifunctional, 容# * (1) rinsing or wet not every ...... ..." does not exclude the following possibilities: (eg enzyme cleaner) is usually used weekly = white shell supplements such as "Molecular Weight Person" of the polymeric material used in the text Unless otherwise stated or unless the test conditions indicate otherwise, it refers to the number average molecular weight. For example, the residual hydrogen peroxide concentration J increased as used herein refers to the absence of an ethyl group in the presence of the same catalyst. Polymer or copolymer: an increased residual hydrogen peroxide concentration of a control solution having the same composition. The percentage of residual ammonium peroxide concentration of the homopolymer or copolymer of (4) ethylene sulfonium (iv) is defined. ... - contact with the heart for 30 minutes) / C control contact for 30 minutes jjxloo of the p ^ ~ flat, L sample contact 3 〇 entry system volume with a vinyl base. Homopolymer or copolymer of ketone The oral ammonia solution and the suitable medium are connected to the plastic container at room temperature for four minutes. 151304.doc 201130524 The residual hydrogen peroxide concentration measured. The I control is contacted with 30 minutes of the same hydrogen peroxide solution (except for the uniform or copolymer of U疋 volume 3 vinylpyrrolidinium) (referred to as the solution of 昭 彳 , | Night) The residual chlorine peroxide concentration 3 measured with the same suitable catalyst at room temperature in contact with the same plastic container for 3 G minutes. The fixed volume enables the catalyst to be fully immersed and tied to about 5 em 25 (10), preferably W to 18-3, more preferably 8' to 13 coffee 3, or even preferably 9 W to U (10) 3. The hydrogen peroxide solution includes hydrogen peroxide and may be used in other suitable components of the contact lens care solution, such as interfacial activity 4, buffers, penetrants. The term "catalyst" according to the invention means any substance which catalyzes the decomposition of hydrogen peroxide. The catalyst is preferably a solid, and more preferably a transition metal metal or metal oxide of the periodic period of the periodic table, or one of the lanthanides, preferably a oxidized nucleus. Different transition metals follow different reaction paths in decomposing peracetic acid. For example, the Applicant believes that peroxides use platinum ions as a catalyst system to decompose according to the following mechanism: H202+Ptn+ -► H20+〇2+ptn+ Shen. It has also been found that peroxides can be decomposed by FentGn reagents, for example, 1 The ion-loaded Fe is oxidized to an iron ion Fe3+, a hydroxyl group, and a hydroxide anion. Iron ion 3+ is then reduced back to ferrous ions, peroxide groups and protons (disproportionation) by the same hydrogen peroxide. H202+Fe2+ -► HO · +HO'+Fe3 + H2〇2+Fe3+·~~►Fe2++〇〇H . +H+ A degree reactive substance hydroxyl group can increase the efficacy of disinfection. The Fenton reagent can act as a catalytic catalyst for the incorporation of platinum or alone in decomposing hydrogen peroxide. I51304.doc 201130524

The source of the Fenton reagent can be, for example, Ti〇2, Fe(N〇3)2, Fe(cy,

Fe(NH4)(S04)2 either contains or is capable of producing other donor compounds of 2+ or Ti3 + iron. Ο

The present invention is generally directed to a hydrogen peroxide disinfecting solution. The present invention is based, in part, on the discovery that homopolymerization of a vinyl ketone is added to a control solution having the same composition in the presence of a homopolymer or copolymer of a vinyl ketone in the presence of the same catalyst. The article or copolymer can provide an increase in residual hydrogen peroxide concentration of at least 鸠, at least 35% or better by at least 5 (%). The present invention also contemplates that a homopolymer or copolymer based on H(10) plus vinyl ketone can provide substantially increased residual ruthenium peroxide upon treatment for 3 minutes. However, the residual hydrogen peroxide concentration remains after 6 hours of treatment. Contact lenses that are reduced to less than 1 GG ppm 'and treated with a hydrogen peroxide solution of a homopolymer or copolymer of ethylene (4) can still be worn comfortably. The invention is based in part on the discovery: B-bake. The presence of a homopolymer or copolymer of bilotone in a hydrogen peroxide disinfecting solution provides (four) properties to the contact lens, which provides (four) increased sexual properties, reduced friction, initial comfort and/or reduced deposit attachment to the lens. Unexpected benefits, thereby increasing the comfort of the contact lens in the eye. While the inventors do not teach any particular theoretical limitations, the Ethylene Base homopolymer or copolymer can act on initial comfort (in the case of wearing glasses). A homopolymer or copolymer having a sufficiently large molecular weight (4) provides slippage between the spectacles and the corneal epithelial tissue. The homopolymer or copolymer of vinyl ketone can increase the lubricity and wettability of the contact lens in the contact lens solution of the present invention 151304.doc -11 · 201130524 (characterized by a decrease in contact angle) / or reduce friction. In the sample, the present invention provides a solution for disinfecting contact lenses, including an effective disinfecting amount of peroxidizing gas and a polymer or copolymer, and the Γ^, 11 alkenylpyrrolidone The homopolymer or copolymer is sufficient to provide at least 20%, preferably at least 20%, relative to a control solution having the same composition in the presence of the homopolymer or copolymer of vinylpyrrolidone in the presence of the same contact medium. An amount of at least 35 〇 / 〇, 哎, and preferably at least 5 〇 ° / 〇 increase in residual hydrogen peroxide agro-amount; and

And an amount sufficient to provide one or more buffers of the composition at a pH of from about 6.0 to 8.0, wherein the composition has an osmotic pressure of from about 4 to about 45 〇 m〇sm/kg and a viscosity as high as ... at the machine. In accordance with the present invention, the contact lens can be a conventional hydrogel contact lens (i.e., non-occupant oxygenated eyeglasses) or preferably a poly 16 oxygen hydrogel contact lens. The solution of the present invention comprises nitrogen peroxide at a concentration suitable for disinfecting purposes, preferably from about 0.5% to about 6% by weight, more preferably from about 2% to about 6% by weight, most preferably about 3% by weight. Between 4% by weight or about 3% by weight. According to the present invention, any copolymer of vinylpyrrolidone and at least one hydrophilic monomer can be used in the present invention. One preferred class of copolymers is a copolymer of vinylpyrrolidone and at least one amine-containing vinyl monomer. Examples of the amino group-containing ethylenic group-containing monomer include, but are not limited to, an alkylaminoalkylmercaptoacrylate having 8 to 5 carbon atoms, and an alkylamine group having 7 to 15 carbon atoms. An acrylate, a dialkylaminoalkylmercapto acrylate having 8 to 20 carbon atoms, a dialkylaminoalkyl acrylate having 7 to 20 carbon atoms, having 3 to 1 carbon atoms N_vinylalkylguanamine. Examples of preferred N-vinylalkylguanamines include, but are not limited to, N-vinyl hydrazine 151304.doc -12- 201130524 decylamine, N-vinylacetamide, hydrazine vinyl isopropyl amide And n_vinyl·Ν·methylethylamine. Preferred copolymers include, but are not limited to, ethylene sulfonium (tetra) hydrazine and = methyl 15 fluorene ethyl decyl acrylate vinegar < copolymerization & Such preferred copolymers are commercially available, for example, Copolymer 845 from Isp and copolymer 937 ° Vinylpyrrolidone at a basis weight per unit volume (w/v). % to about 5% 'preferably 0 · ^ 3%, more preferably from about 5% to about 2%, most preferably from about 0 · 25 ° / 0 to about 1.5 %. The compositions of the present invention preferably comprise a buffer. Preferably, the buffer maintains the pH within the desired range, e.g., within a physiologically acceptable range of from about 4 or about 5 or from about 6 to about 8 or about 9 or about 丨0. In particular, the solution preferably has a pH of from about 5.5 to about 8 and the buffer is selected from inorganic or organic tests, preferably acetate, phosphate, borate, citrate, nitrate. Sulfates, tartrates, lactates, carbonates, bicarbonates, and mixtures thereof, more preferably basic phosphates, borates, citrates, tartrates, carbonates, bicarbonates, and mixtures thereof. Usually, it is present in an amount of from 0.001% to 2%, preferably from 0.01% to 1%, optimally from about 0.05% to about 0.30% by weight per unit volume. Preferably, the buffer component comprises one or more phosphate buffers such as a combination of a dihydrogen phosphate, a dibasic phosphate, and the like. Particularly useful canister buffers are those selected from the group consisting of alkali metal and/or alkaline earth metal silicates. Examples of suitable phosphate buffers include one or more of diammonium phosphate (Na2HP04), sodium dihydrogen phosphate (NaH2P04), and dihydrogen phosphate (ΚΗ2Ρ〇4) 151304.doc -13·201130524. Another buffer. A preferred buffer system comprises one or more boric acid. The solution according to the invention is preferably formulated so as to be in the form of a tear. It is generally understood that the solution which is isotonic with tears is a solution of the concentration of the solution in the concentration of 〇 9% of the sodium hydride solution (308 m 〇 sm / kg). Deviation from this concentration is also acceptable. The properties of the tears, or even the desired isotonicity, can be adjusted by the addition of an organic or inorganic substance f which affects isotonicity. Suitable eyes^ Acceptable osmotic agents include, but are not limited to, sodium gasification, potassium glycerin, glycerin, propylene glycol, polyethylene glycol, polyols, mannitol, sorbitol, xylitol, and mixtures thereof. Preferably, most of the solution is provided by a group or compounds selected from the group consisting of non-deuterated electrolytes (e.g., acid chloride) and non-electrolyte compounds. The permeability of the solution is typically adjusted to a range of from about 200 to about 450 units, m0sm, preferably from about 250 to 3 50 m〇sm. The compositions of the present invention may comprise a mixture of surfactants or surfactants. The surfactant can be virtually any ocular acceptable surfactant' which includes nonionic, anionic, and amphoteric surfactants. Suitable surfactants - generally described as hydrophilic with a - or a secondary base, and a copolymer of dredged materials. A first example of such surfactants is a polyoxyalkylene/polyoxypropyl propylene condensation polymer terminated with a grade. It can be synthesized by controlling the addition of propylene oxide to the two hydroxyl groups of propylene glycol, first producing a hydrophobe of a desired molecular weight. In the second step of the synthesis, ',', oxyethylene is fused to sandwich the hydrophobe between the hydrophilic groups. These 15I304.doc -14- 201130524 block copolymers are commercially available from BASF Corporation under the trade name PLURONIC®. A second example of such surfactants is a secondary hydroxyl terminated polyoxyethylene/polyoxypropyl condensed polymer. It can be synthesized by controlling the addition of ethylene oxide to ethylene glycol to first produce a hydrophilic substance (polyoxyethylene) of a desired molecular weight. In the second step of the synthesis, propylene oxide is added to produce a hydrophobic block outside the molecule. Such block copolymers are commercially available from BASF Corporation under the tradename PLURONIC® R. Specific examples of satisfactory PLURONIC® R surfactants include: PLURONIC® 〇 31R1, PLURONIC® 31R2 'PLURONIC® 25R1, PLURONIC® 17R1, PLURONIC® 17R2, PLURONIC® 12R3. Particularly good results were obtained with PLURONIC® 17R4 surfactant. The PLURONIC® alpha-numeric combination is used to identify different products in the series. The alphabetic symbol explains the physical form of the product: "L" is a liquid, "P" is a paste, and "F" is a solid form (all at 20 °C). In the number sign ◎ The first number (two of the three digits) multiplied by 300 indicates the approximate molecular weight of the hydrophobe (polypropylene oxide). The last digit is multiplied by 10 to indicate an approximate percentage of the poly Ethylene Ethylene content of the molecule. - The letter "R" in the middle of the symbol of the PLURONIC® R series indicates that this product has the opposite structure as the PLURONIC® product, ie the hydrophilic (ethylene oxide) is sandwiched between the propylene oxide blocks. When the number sign before "R" is multiplied by 100, the approximate molecular weight of the propylene oxide block is indicated. When the number after "R" is multiplied by 10, it indicates the approximate weight percentage of ethylene oxide in the product. Examples of preferred surfactants include, but are not limited to, poloxamer 151304.doc -15- 201130524 (poloxamer) (eg, Pluronic® L35, L43, L44, L62, L62D, L62LF, L64, L92, F108, F123, F88, F98, F68, F68LF, F127, F87, F77, P84, P85, P75, P103, P1 04, P1 05 and 1 7R4), poloxamine (eg Tetronic® 707, 11 07) And 13 07), poly(ethylene ester) of fatty acid (for example, Tween® 20, Tween® 80), polyoxyethylene or polyoxyl propyl ether of Ci2 to C! ® 35), polyoxyethylidene stearate (Myrj® 52), polyoxyethylene ethyl propylene glycol stearate (Atlas® G 2612) and amphoteric surfactants under the trade names Mirataine® and Miranol®. The amount of surfactant component can vary widely depending upon, for example, one or more of the particular surfactants employed, other components of the composition, and the like. For example, for the PLURONIC® series of surfactants, typically the amount of surfactant is in the range of from about 0.0001% or from about 0.0002% to about 0.03% or from about 0.05% or about 0.08% (w/v). Preferably, the surfactant is present in an amount of less than 0.02%; and optimally less than 0.04%. In another example, non-PLURONIC® R series surfactants, such as PLURONIC® R, typically have a surfactant amount of from about 0.005% or from about 0.01% to about 0.1% or from about 0.5% to about 0.8% per ton ( Within the scope of \¥~). Preferably, the surfactant is less than 0.2°/. ; and the best amount is less than 0.1%. The contact lens solution of the present invention may comprise a viscosity enhancing polymer' which may be a water soluble cellulose derived polymer, a water soluble polyvinyl alcohol (PVA) or a combination thereof. Examples of useful cellulose-derived polymers include, but are not limited to, cellulosic ethers. Exemplary preferred cellulose ether methyl cellulose (MC), ethyl fiber 151304.doc • 16· 201130524 vitamin (EC), hydroxymethyl cellulose (HMC), hydroxyethyl cellulose (HEC) , perpropyl cellulose (HPC), hydroxypropyl methylcellulose (HpMc) or a mixture thereof. More preferably, the cellulose ether is hydroxyethyl cellulose (HEC), hydroxypropyl decyl cellulose (HPMC), and mixtures thereof. The cellulose ether is preferably present in the composition in an amount of from about 1% by weight to about 5% by weight based on the total amount of the lens care solution. The desired viscosity of the lens care solution is at 25 ° C up to about 5.0 centipoise.

According to the present invention, the solution may further comprise a mucin-like substance, a substance beneficial to the eye phthalocyanine, hyaluronic acid and/or a surfactant. Exemplary mucin-like substances including, but not limited to, polyglycolic acid and polylactide class I mucin substances can be used as guest materials which can be continuously and slowly released to the eye surface of the eye for a long time for the treatment of dry eye syndrome. . Preferably, the axon material is present in an effective amount. Exemplary eye-friendly materials include, but are not limited to, 24 singular ketones - 5-acids (PCA), amino acids (eg, bovine acid, glycine, etc.), & basic acids (eg, ethanol) Acid, lactic acid, anaphyl, tartar, mandelic acid, citric acid and its salts, linoleic acid and gamma linoleic acid, and vitamins (eg Μ, A, Β6, etc.). The spectacles can be prepared from a hydrogel lens forming formulation according to any method known to those skilled in the art. "Hydrogel glasses forming a formulation" or ": agglomerating eye forming material" means a polymeric material which can be cured by heat or photochemistry (i.e., by poly: or parent) to obtain a crosslinked/polymerized polymeric material. Glasses forming materials are well known to those skilled in the art. In general, = chemically formed materials include polymerizable/crosslinkable fractions, such as, for example, familiar with this item: 151304.doc 】 7 201130524 The monomer known to the surgeon, p 八 y — giant knife, pre-t or Its combination. The lens forming material can be improved to include other components such as non-crosslinkable hydrophilic polymers (ie, filter out of polymeric lubricants), initiators (eg, photoinitiators or thermal initiators), visibility colorants' uv Blockers, sensitizers, antibacterial agents and the like. In another aspect, the present invention provides a method of disinfecting a contact lens comprising the steps of: (4) contacting the contact lens with an aqueous solution containing the following components: an effective disinfecting amount of hydrogen peroxide and a vinyl bite a polymer or copolymer in which the homopolymer or copolymer of vinylpyrrolidone has the same color as the homopolymer or copolymer which does not contain vinyl anthracene in the presence of the same catalyst. a control solution sufficient to provide at least 20% increase in residual hydrogen peroxide moisture, in an amount sufficient to provide one or more buffers of the composition from about 6.8 to about 8. 令, such combination The osmotic pressure of 200 to about 450 mOsm/kg and the viscosity of up to about 5.0 cps at 25:7; and (b) neutralizing the hydrogen peroxide by catalytic decomposition. The previous disclosure will enable one of ordinary skill in the art to practice the invention. In order to provide readers with a better understanding of the specific embodiments and advantages thereof, it is suggested to refer to the following non-limiting examples. However, the following examples should not be construed as limiting the scope of the invention. The following non-limiting examples illustrate certain aspects of the invention. Example 1 (cutting technique) - Scavenging treatment solution (4) Purchased from Ciba visi〇n Some of the following liquid compositions (in units of weight percent (w/v)) were prepared by blending individual ingredients. 151304.doc 201130524 Hydrogen peroxide 3.5% Dihydrogen sulphate, monohydrate 0.072% Disodium hydrogen phosphate, anhydrate 0.1555% DEQUEST® 2060S 0.012% Gasification nano 0.79% PLURONIC 17R4 0.05% Purified water to volume The solution contains 3.5% hydrogen peroxide; 0.072% sodium dihydrogen phosphate, one Ο

Hydrate; 0.1555% disodium hydrogen phosphate, anhydrate; 0.012% DEQUEST® 2060S; and 0.79% sodium chloride and 0.05% aqueous solution of PLURONIC 17R4. Example 2 A solution was prepared in the same manner as in Example 1, except that 1% of the copolymer 845 was added to the solution. Copolymer 845 was obtained from ISP. Example 3 A solution was prepared in the same manner as in Example 1, except that 1% copolymer 845 and 0.02 °/ were added. HPMC Ε4Μ to the outside of the solution. Copolymer 845 was obtained from ISP, and HPMC® was obtained from DOW. Example 4 A solution was prepared in the same manner as in Example 1, except that 1.0% of the copolymer 845 was added to the solution. PLURONIC P103 (0.001%; ^RPLURONIC 17R4. PLURONIC P103 was obtained from BASF. Example 5 A solution was prepared in the same manner as in Example 1, except that 0.5% copolymer 845 151304.doc -19-201130524 was added to the solution. 0.001% PLURONIC P103 instead of PLURONIC 17R4 ° Example 6 A solution was prepared in the same manner as in Example 1, except that 0.64% borate buffer was used instead of phosphate buffer, and 1.0% copolymer 845 and 0.02% HPMC E4M were added to the solution. Peroxide concentration after peroxide neutralization at 30 minutes and 360 minutes (Platinum coated disk system using AOCUP and AOSDis) Table 1A - For the above example in the AOCup system with AODisc after disinfection Peroxide content in a contact lens solution at a specific time point (30 minutes or 360 minutes) and 30 minutes in a neutral period of 360 minutes Example I (n = 5) 1080.64 ppm Ten / - 99.52 ppm 2.75 ppm + A 0.07 ppm Example II (n =4) 1678.33 ppm +/- 124.92 ppm 8.05 ppm +A 0.21 ppm Example ΙΙΙ (η=15) 2397.11 ppm +/- 297.26 ppm 12.60 ppm +/- 0.28 ppm Example IV (n=6) P26 2055.56 ppm +/- 186.94 ppm 9.15 ppm +/- 0.56 ppm Example V ( n=6)P35 2385.00 ppm +/- 606.21 ppm 14.78 ppm +/-1.18 ppm Example VI (n=6) N35 2063.33 ppm +/- 185.53 ppm 12.85 ppm +/- 0.54 ppm Table 1B - For Example I above, 卩And 111 in a AODisciA® Cup system at a specific time point (60 minutes) after disinfection in a peroxide content contact lens solution and 60 minutes Example I (n=4) 499.5 ppm +/- 29.86 ppm Example II (n =2) 826 ppm +Λ 16.97 ppm Example ΙΙΙ(η=4) 824.0 ppm +/- 22.33 ppm Characterization of contact lens solution Determination of Example 1 using a Southern Micro-osmometer Model 3300 The osmotic pressure of the contact lens solution to 6. 151304.doc •20- 201130524 The final results were obtained as the average of at least three test results for each contact lens solution. The viscosity of the contact lens solutions of Examples 1 to 6 was obtained by taking the average of three measurements at a specific predetermined speed using a Brookfield viscometer (in this case the best results were obtained at 60 rpm) . The pH values of the contact lens solutions of Examples 1 to 6 contact lens solutions were determined using a Fisher Accumet 25 pH meter (average of two independent test results for each package solution). Table 2 - Ι1, osmotic pressure and viscosity contact lens solution example number PH osmotic pressure viscosity after sterilizing a specific time point (360 minutes) in the AOCup system with AODisc Example I (n=5) 6.69 + /- 0.01 294+/-1.00 mOsm 0.92 +A 0.02 cps Example II (n=30) 6.64+/-0.01 294 +/- 1.00 mOsm 1.45 +/- 0.02 cps Example III (n=30) 6.63 +/- 0.01 297 +/- 2.1 mOsm 1.62 +Λ 0.01 cps Example IV (n=3) 7.05 +/- 0.01 308 +Λ 1.5 mOsm 1.33 +/- 0.02 cps Example V (n=l〇) 6.72 +/- 0.01 296 +Λ 2.1 mOsm 1.10 +/- 0.02 cps Example VI (n=3) 7.11 +/-0.01 296 +/- 1.5 mOsm 1.61 +/_ 0.02 cps 〇All neutralization examples are in the best eye pH comfort range of 6.6 - 7.2 The physiological pH was 6.8. All neutralized examples ranged from 280 mOsm to 320 mOsm in optimum permeability, with a physiological permeability of 29 〇 m〇srn. Analysis of the characteristics of the glasses The coefficient of friction of the contact lenses can be measured by a sled_on_block friction tester on a block as follows. The contact lens is slid back and forth relative to the biologically relevant substrate at a specified speed (e.g., about 4 grams) and the normal force tangential force is measured. The friction system of contact lenses 151304.doc •21- 201130524 The number system is based on the equation μ=Ι?τ/Ν. The preferred friction tester for the glass comprises: a fixed eyeglass holder substrate, a horizontal movable platform and a plurality of force measuring members. Preferably, the spectacles disarmer assembly includes a "Α" shaped disarmer bracket and a spectacles holder having a spectacles support surface. The lens support surface of the lens holder has a convex curvature that can accommodate the back (concave) face of the contact lens. Preferably, the eyeglass holder is held by a member positioned in the center of the "Α" shaped holder bracket. The head end of the "A-shaped" fixed sample moxibustion holder is attached to the first load cell (e.g., a force gauge from Transducer Techniques) by, for example, Kevlar® fibers. The two ends of the "A-shaped" gripper bracket are attached to a nylon thread that utilizes two 1/2, steel stretched elastomers. The first load cell and the steel tension spring are mounted to the frame of the tester. The horizontally movable platform can be, for example, a mesa platform & mesa, and is uniaxially moved at different speeds and accelerations. The χ_ countertop is preferably and has a (6) face length and a width of 19.1 mm and can provide a test area having a length of about 14 mm and a width of about M. 7 mm. - One example of a table is by zeta Drive C〇mpumotor (Parker Η_Πη.叩(10)u〇n) A push-type μ linear positioner that operates in one direction at a maximum speed of 18 mm/min and an acceleration of 卯(9) mm/s2. In the case of the formula, the glass substrate should be cleaned by rinsing with hot water followed by rinsing with isopropyl alcohol. The glass substrate attached to the x_ table is lubricated with a 5 〇 μΐ period (4) slip #_如 'phosphate buffered saline solution or a lens encapsulation solution). The desired lubricant should be applied to the glass substrate. Preferably, there are three force measuring members, the first, second and third force measuring structures 151304.doc -22- 201130524 pieces. Any suitable known force measuring member can be used. An example is a 100-gram force estimator from Transducer Techniques. The first load cell is attached to the sample holder to measure the tangential force (friction, FT) in two opposite directions. The second and third force measuring members are located below the x_ table to measure the normal force (N) in the downward direction. The other dynamometer values output by the normal dynamometer are converted to grams by means of a multi-purpose amplifier/regulator (Transducer Techniques).

The coefficient of friction measurement is performed on a preferred friction tester in the following steps. The contact lens is placed on the eyeglass holder such that the back of the contact lens rests against the eyeglass support surface of the eyepiece holder. The eyeglass holder with the contact lens is combined with the A-shaped "clamp holder" and subsequently brought into contact with the lubricated glass substrate. The substrate is mounted to a horizontal movable mesa platform that can be uniaxially moved at different speeds and accelerations. Approximately 4 grams of weight was loaded onto the lens holder. This load can represent the force exerted by the eye exam on the contact lens. The two force measuring members (3 from the Transducer Techniques) measure the normal direction (9) and self-contact lens and the desired lubricant lubrication. The friction (FT) force generated by the interaction between the substrates. In the measurement of the contact lens friction coefficient (four) take multiple data points. At each data point, the friction system (4) τ/Ν is calculated as follows, where Ft represents the glass substrate (4) in the invisible eye ^ bone movement ^ in the correction by the elastic 篑 (the tangential force please provide the preload r ' force component obtained The actual data reading at each point, the second gram unit; _Νι and N2; Νι represents the correction in the substrate relative to the 艮 mirror sliding during the calibration by the test assembly (normal measurement W before the preload] by the second The 151304.doc •23- 201130524 actual data readings obtained by the force-measuring members, and their preferred positive readings during contact with the contact lens at η, at the substrate weight are being tested by the test assembly (normal dynamometer = The actual data reading at each point obtained by the third load cell after any preload, and preferably in grams units. All π averages (μΑνε) at the data points are used to represent the invisible friction coefficient. Preferably, the friction tester further includes a computer system that controls the tester, collects the readings of the normal and tangential forces while calculating the interaction between the biologically relevant substrate and the contact lens, calculates the friction coefficient, and recordsThe force (Ft&n) and the coefficient of friction (8) at each data point during the formation are plotted. The static friction is the frictional force on the object when it is placed on the substrate. Calculate the static friction coefficient (8) and calculate the actuation. The most required of the object: force (F) and divide it by the normal force (N) on the object. Dynamic friction is the frictional force on the object as it moves on the substrate. Invisible with examples 1 to 6. The contact angle, dynamic friction coefficient and static friction coefficient measured by the sessile drop method of the spectacles treated by the glasses solution are recorded in Table 3. Table 3_Peroxide Neutralization in the AOCup System with AO Disc ( Contact angle measurement after 6 o'clock) (by seat drop method) and friction coefficient test contact lens solution example number --------- seat drop contact angle (degrees) (〇asys glasses) - dynamic friction coefficient ( n=l〇; AirOptix __ glasses) 0.026+/-0.001 -___^Example I 99 +/- 8 (η-10) — 60 +/- 20 (η=5) 0.018 +/- 〇005 -- 60 +/-14 (n=30) L__^〇08 +/- 0.002 151304.doc 24· 201130524 ------ -- 30+/-12 (n=10) 0.008 +/- 0.002 ___ -foil V _ 47 +/- 2 2 rn=23) 0.009 +/- 0.002 49 +A 11 (n=5) 0.010+/-0.003 Although specific examples, devices and methods have been used to illustrate different embodiments of the invention, the description is for illustrative purposes only. purpose. The words used are non-limiting. It is to be understood that those skilled in the art can make changes and variations without departing from the spirit or scope of the invention as set forth in the following claims. In addition, it should be understood that aspects of the various embodiments may be interchanged in whole or in part. Therefore, the spirit and scope of the appended claims should not be limited to the description of the preferred embodiments. 151 151304.doc 25-

Claims (1)

201130524 VII. Patent Application Range: A solution for a 4-toxic contact lens comprising an effective disinfecting amount of a hydrogen peroxide and a homopolymer or copolymer of vinylpyrrolidone, wherein the ethyl thiopyrrolidone The homopolymer or copolymer is sufficient to provide at least a 20% increase in residual peroxidation relative to a control solution having the same composition as a homopolymer or copolymer of vinylpyrrolidone in the presence of the same catalyst. An amount of hydrogen concentration is present; and an amount sufficient to provide one or more buffers of the composition at a pH of from about 6 Torr to about 8.0, wherein the composition has an osmotic pressure of from about 2 Torr to about 450 mOsm/kg and at 25 . The squat is as high as about 5 〇 centipoise. 2. The solution according to claim 1, wherein the solution comprises a copolymer of vinylpyrrolidone and at least one amino group-containing vinyl monomer, wherein the amino group-containing vinyl system is selected from the group consisting of 8 to 15 Alkylaminoalkyl methacrylate of a carbon atom, alkylaminoalkyl acrylate having 7 to 15 carbon atoms, dialkylaminoalkyl group having 8 to 2 carbon atoms A group consisting of a propylene group of 8 Å, a dialkylamino acrylate acrylate having 7 to 20 carbon atoms, and a fluorenyl vinyl decylamine having 3 to 1 carbon atoms. 3. The solution of claim 1, wherein the contact lens is a polyoxygenated hydrogel contact lens. 4. The solution of claim 2, wherein the amino-containing vinyl system is monomethyl montethyl ethyl methacrylate or dimethylaminoethyl acrylate. 5. The solution of claim 1 wherein the solution is at 25. (: having a viscosity of up to about 2.0 centipoise. 151304.doc v 201130524 6. The solution of claim 1, further comprising a solution selected from the group consisting of methyl cellulose (MC), ethyl cellulose, Hydroxymethyl cellulose, hydroxyethyl cellulose (HEC), hydroxypropylcellulose (HPC), hydroxypr〇pyimethyl cellulose (HPMC) and mixtures thereof 7. A tackifier. The solution of claim 1 wherein the concentration of the tackifier is from about 0.001% to about 0.5% by weight based on the total weight of the solution. 8. The solution of claim 1 further A buffer selected from the group consisting of a phosphate buffer and a borate buffer. 9. The solution of claim 1, further comprising a group selected from the group consisting of: 17r4 and 丨 rainbow 〇 114 〇 1 〇 3 Surfactant 10. If the machine solution is requested, the concentration of the peroxide is about 3% based on the total weight of the solution. 11. (4) The solution of the solution, wherein the vinyl pyrrolidine _ homopolymer The concentration of the copolymer is based on the weight of 3M About 0.1% to 5% (_). 12. If the solution of IM11 is requested, the concentration of the homopolymer of the material of the material (4) is in the unit volume and the weight is about 0.25% 1.50/〇 (w/ v) 0 13_ as the solution of the claim ' 'where the increased residual peroxidation 5 is at least 35%. Milk ' 14. The solution of claim 1 wherein the increased residue is at least 50%. - A method of disinfecting a contact lens, comprising the steps of: (a) contacting the contact lens 151304.doc 201130524 with an aqueous solution containing the following components: an effective disinfecting amount of hydrogen peroxide and a homopolymer of vinylpyrrolidone Or a copolymer wherein the vinyl group. The homopolymer or copolymer of the pyridinium is the same as the homopolymer or copolymer of the pyrrolidone in the absence of a vinyl group in the presence of the same catalyst. a control solution sufficient to provide at least a 20% increase in residual hydrogen peroxide concentration; and an amount sufficient to provide one or more buffers of the composition at a pH of from about 6 to 8 Torr, wherein the composition has about An osmotic pressure of from 200 to about 450 mOsm/kg and a viscosity of up to about 5.0 centipoise at 25 ° C; (b) neutralizing the hydrogen peroxide by catalytic decomposition. 16. The method of disinfecting a contact lens of claim 15, wherein the neutralizing step comprises contacting the s-hai solution with a metal catalyst. The method of 15, wherein the increased residual hydrogen peroxide concentration is at least 35 %. 18. The method of claim 5, wherein the increased residual hydrogen peroxide concentration is at least 5 Å. . 19. The method of disinfecting a contact lens of claim 16, wherein the metal catalyst is initiated. 20. The method of disinfecting a contact lens of claim 16, wherein the metal catalyst is a Fenton reagent or a combination of platinum and Fent〇n reagent. 151304.doc 201130524 IV. Designated representative map: (1) The representative representative of the case is: (none) (2) The symbol of the symbol of the representative figure is simple: 5. If there is a chemical formula in this case, please reveal the best indication of the characteristics of the invention. Chemical formula: (none) 151304.doc