TW201124085A - Antibacterial composition, antibacterial articles and antibacterial method - Google Patents

Abstract

Disclosed is an antibacterial composition comprising calcium hydroxide and an element of boron, in which the content of the element of boron is above about 0.05%, preferably above about 0.2%, in the total mass of the antibacterial composition. Also disclosed is an antibacterial product containing the antibacterial composition. The product of the present application has a high safety and can be prepared at a lower price.

Description

201124085 VI. Description of the invention: [Technical field to which the invention pertains] The original (four) material anti-surge (4) contains #抗8 to (4) antibacterial products, and the antibacterial composition contains calcium hydroxide and boron. [Prior Art] [_- Straight, people have adopted various methods and their minds (4) antibacterial properties. For example, antibacterial agents have been proposed which have been obtained from natural antibacterial agents such as silver ions or zinc ions, which are natural antibacterial agents such as citrus extracts or chitosan. . Among them, organic resistance _ has (four) sex (four) - face. However, in general, due to its fast dissolution rate in the product, the resulting product lacks sustained secrets. μ, the organic antibacterial agent selected under the premise of pure requirements of the shirt is difficult to achieve the desired antibacterial effect. _] In addition, when the solubility of the antibacterial agent in the synthetic resin is low, white turbidity may occur or the gloss may be lowered and the sweat may be converted to a product. The inorganic anti-seismic or zinc-based inorganic anti-(four), because of its relatively high safety, can exert antibacterial properties against a wide spectrum of bacteria and has been used in various forms in various synthetic resin products. However, in order to impart such an inorganic anti-bacterial property to the resin, in the process towel mixed with the resin, as the anti-g component (tetra) ion or the like, the transparency of the resin is lowered, the discoloration is caused, or the resin is easily deteriorated. . Further, when the silver ion-based antibacterial agent is mixed into the entire resin, the antibacterial property existing in the molded product of the molded article cannot exhibit antibacterial properties. The other side is because the inorganic antibacterial agent itself is not cheap, which causes the birth. 099101147 Form No. A0101 Page 3 of 27 09920023] 201124085 The problem of increased production costs. [0007] In order to solve these problems, it has been proposed to disperse a fine powder inorganic antibacterial agent in a solvent such as ethanol, and to impart antibacterial property to the product by spraying, coating, or plating a surface coating film containing the antibacterial agent onto the surface of the molded article. Sex. In addition, the method of the publication of the Japanese Patent Publication No. Hei. No. Hei. No. Hei. No. Hei. [0008] Although the above-mentioned inorganic antibacterial agent using silver ions or reciprocating ions has relatively high safety, it is not denied that there is still a possibility of endangering human health due to chronic ingestion, and the disposal problem after use should be treated with caution (due to Air pollution caused by incineration, soil pollution in landfills, possibility of reuse, etc.). Further, in the method of imparting antibacterial properties to a surface of a synthetic resin molded article by coating, if the product is scratched or a long period of time, the antibacterial property is inevitably lowered. Further, calcium hydroxide which has been mainly used as a filler and a stabilizer has been proposed to be mixed into a synthetic resin to form a resin composition containing calcium hydroxide because of its antibacterial property. However, in order to achieve the desired antibacterial effect, it is necessary to add a considerable amount of calcium hydroxide (it is usually necessary to add 16 parts by weight or more with respect to 100 parts by weight of the synthetic resin). However, this may impair the mechanical strength, surface appearance, and the like of the product (for example, Patent Publication No. 2001-1 23071). [00113] The present invention is based on the above-mentioned situation, and the problem to solve the above problem is 099101147. Form No. A0101, Page 4/27, 0992002311-0, 201124085 [0012] [0013] [0014] 99 [0015] 099101147, which provides An antibacterial resin product and an antibacterial composition which are safe, inexpensive, and easy to manufacture. The resin product of the present invention does not reduce its own various characteristics (e.g., mechanical properties, etc.) after being mixed into the antibacterial composition. SUMMARY OF THE INVENTION The present inventors conducted intensive studies to solve the above problems. The inventors have unexpectedly found that an antibacterial composition containing more than 0.05% by weight of boron element and having calcium hydroxide as a main component has excellent antibacterial properties. At the same time, an appropriate amount of the antibacterial composition containing 0.05% by weight or more of boron element and containing calcium hydroxide as a main component is mixed with a thermoplastic resin or a thermosetting resin to obtain a resin product having an excellent antibacterial effect without lowering it. Physical properties such as mechanical strength. 0%, preferably about 0.2%, more than about 0. 25%, preferably about 0.2% the above. Another aspect of the present invention relates to an antibacterial composition which is obtained by calcining a shell; adding water to the calcined product to prepare a composition having calcium hydroxide as a main component; if necessary, preparing the shell 0以上以上。 Preferably, the amount of the composition is about 0. 05% or more, preferably about 0.2% or more. A further aspect of the invention relates to an antibacterial article comprising about 100 parts by weight of a thermoplastic resin and about 0. 02-2. 99 parts by weight of the antimicrobial composition or comprising about 100 parts by weight of a thermosetting resin and about 0. 0 5%以上以上优选优选0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2% or more, or the antibacterial combination form number Α0101 5th page/total 27 pages 0992002311-0 201124085 The object is obtained by the following method: simmering the shell; adding water to the simmered product to obtain calcium hydroxide 5%以上以上。 Preferably, the composition of the composition of the composition of the composition of the total weight of the composition of the composition of the total weight of the composition of about 0. 0 5% or more, preferably about 0.2% or more. 8%,优选优选为1-5%。 In the above-mentioned antibacterial composition, the amount of boron may be from about 0. 0 5-10%, preferably 0. 2-8%, more preferably 1-5%. Typically boron is present in the composition in the form of boron oxide. [0017] A further aspect of the invention relates to an antibacterial method comprising applying an effective amount of the above-described antimicrobial composition to an article in need of antibacterial composition, the antibacterial composition comprising calcium hydroxide and boron, and the content of the boron element is 0以上以上。 The total weight of the antibacterial composition of 0. 0 5 % or more. The micro-powder of m-lOvm. The micro-powder having an average particle size of 0.5 m-lOvm. Antibacterial products containing such powders are more satisfactory. 8%以下。 Preferably, the amount of the antibacterial composition is less than 0.8%, preferably 0.4% or less. In certain embodiments of the invention, the antibacterial composition produced does not contain iron. [0020] The antibacterial composition used in the antibacterial article of the present invention contains calcium hydroxide as a food additive as a main component, and is superior to an antibacterial agent containing silver ions or reciprocating ions for the main plastic addition in the conventional method. It has the characteristics of high stability and low cost. [0021] Even if the amount of the antibacterial composition added to the resin is small, the antibacterial product of the present invention 099101147 Form No. A0101 Page 6 / 27 pages 0992002311-0 201124085 can also fully exert the high antibacterial required for tableware. Sexuality, without destroying the mechanical properties of the resin and its appearance. [0022] In certain embodiments of the antimicrobial articles of the present invention, the antimicrobial compositions used, particularly the micronized antimicrobial compositions, are evenly distributed throughout the material to provide an antibacterial effect more southerly. In this case, even if the surface of the product is scratched, the antibacterial property is not lowered. Further, the antibacterial article of the present invention can be used for each of the articles including the diaper article because the above-mentioned highly safe and inexpensive antibacterial material is used.

Kind of products. In particular, it can provide safe & fungus products directly in direct contact with hands or skin, such as keyboards for computers, etc., buttons for various mechanical devices, remote control buttons, tableware, cutting boards or metal bowls, etc., toilets 'Bathroom/washroom floor materials or wall materials, as well as other wall materials such as rings or elevators. [Embodiment] The antibacterial article of the present invention comprises an antibacterial composition containing calcium hydroxide and a boride, and a thermoplastic resin or a thermosetting resin.

[0034] The invention is described in more detail below in terms of specific embodiments and/or examples. 099101147 [0026]

An "antibacterial composition," (also referred to herein as "antibacterial agent", unless otherwise stated, both of which have the same meaning) of calcium hydroxide, is a conventional calcium hydroxide in the art. In certain embodiments of the invention, the calcium hydroxide is prepared by methods known to those skilled in the art, such as calcined calcium carbonate to obtain calcium oxide, and then Form No. A0101, page 7 / total 27 pages 0992002311-0 [ 0028] 201124085 Hydration. [0029] In certain embodiments of the invention, an animal-derived mother may be employed as a source of carbon. Exemplary animal species that can be used in the present invention include i_ not limited to scallop shells, remnant shells, conch shells, surf shells, sea urchin shells, and the like, or shells of shellfish, or shells. As raw materials. In certain embodiments t of the invention, scallop shells are used as the source of the animal (iv) of the invention. Since the shell has the characteristics of uniform composition and sufficient supply, and the shells and the shells are simmered, no other treatment is required, and the obtained product can be directly hydrated to prepare a raw material of the anti-I composition. [0030]

In certain embodiments of the invention, the shell is corrected into a shell powder (or granule) at 8 ° C, 20 (TC, preferably 850. (: - 1,000 ° C) In the meantime, carbon dioxide can be introduced. The smoldering can be ordered in the air and can be carried out in an inert gas such as nitrogen. The appropriate smoldering time can be set according to the simmering temperature, but usually the air temperature reaches the predetermined sinter temperature. After 1 minute _12 〇 minutes, excellent mobilization 15 minutes _9 〇 minutes. Through such a treatment 'can be used to decompose unwanted organic matter by heat. [0032] [0032] After simmering, it can be hydrated Calcium hydroxide is the main powder. In some embodiments of the present invention, in the process of calcining and hydrating, the powder may be further pulverized as needed to prepare a fine powder, and the final average particle size of the fine powder may be 0*1. Vm~500 is from m, preferably from 0.5 gm to 100, more preferably from 0.5 yra to 4 Å, and most preferably from 0.5 /zm to 〇β m. The powder antibacterial combination is obtained by further micronizing the particle size of the particles. When mixed with thermoplastic resin or thermosetting resin, it can achieve uniformity 099101147 Form No. A0101 Page 8 of 27 0992002311-0 201124085 [0033] [0036] [0036]

[0037] 099101147 Dispersion, that is, sufficient to impart antibacterial ability to the product. In some embodiments of the present invention, if the concentration of boron element in the powder prepared from the animal calcium source is low, boron oxide or the like may be added to the prepared fine powder mainly composed of calcium hydroxide as needed. The fine powder containing boron element is thoroughly mixed and uniformly, and a powder antibacterial composition is obtained. 0重量重量的重量重量的重量的重量重量的质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量质量重量2重量百分比以上。 The above, preferably 0.2% by weight or more. 8%,优选优选为五重量。 In some embodiments, the amount of the boron compound in the antibacterial composition may be from about 0.05 to 10%, preferably from 0. 2-8%, more preferably 5%. The 8% or less, preferably 0.4% or less, of the total weight of the antibacterial composition. . In some embodiments of the invention, the resulting antimicrobial composition does not contain iron. In some embodiments of the present invention, illustrative examples of thermoplastic resins that can be mixed with the antimicrobial composition include, but are not limited to, polyethylene resins, polypropylene resins, polystyrene resins, polyvinyl chloride. Resin, polyamide resin, polycarbonate resin, polyacetal resin, PET (polyethylene terephthalate) resin, PBT (polybutylene terephthalate) resin, ABS (acrylonitrile-butadiene) An ene-styrene resin or the like. In some embodiments of the present invention, the thermoplastic resin for a cooking utensil such as a cutting board or a keyboard of a computer or the like is selected from the group consisting of polyethylene resin, polypropylene tree form No. A0101, page 9 / total 27 pages 0992002311-0 [0038 [0044] [0044] [0044] A grease, an ABS resin or a PBT resin. In some embodiments of the present invention, the antibacterial composition is blended in an amount of from 0.2 part by weight to 2.99 parts by weight 'preferably at least 0.1 part by weight, more preferably 100 parts by weight of the thermoplastic resin. More than the weight. 1.0 parts by weight to 1.9 parts by weight is particularly preferred 'usually 2.0 parts by weight to 2.5 parts by weight. In certain embodiments of the present invention, illustrative examples of thermosetting resins that can be mixed with the antimicrobial composition include, but are not limited to, unsaturated polyester dendritic epoxy resins, phenolic resin, melamine resins, and acrylic acid resins. , urea resin, polyimide resin, enamel resin, and the like. In some embodiments of the present month, the antibacterial composition is added in an amount of 重量 5 parts by weight to 5% by weight of the thermoplastic resin, more preferably 15 15 parts by weight to 3 parts by weight. Antibacterial In some embodiments of the present invention, it is practically necessary to add an additive conventionally used in a molded article made of a thermoplastic resin or a hot tree, such as a plastic, to the k-product of the present invention. Agents, stabilizers, fillers, UV absorbers, colorants (pigments, materials, etc.), .I μ i, nin brighteners, anti-inflammatory agents, viscosity modifiers, etc. In the anti-product of the present invention, the above-mentioned powder antibacterial composition and the thermoplastic can be obtained by a single-loading machine, a two-axis extruder, a kneader, a stirrer, and a double machine known to those skilled in the art. Resin kneading

099101147 Form No. A〇l〇i Page 10 of 27 Page 0992002311-0 [0045] 201124085, after mixing thoroughly to homogenize, using injection molding, extrusion molding, blow molding, etc., to achieve the desired shape. Or by a calendar process or a casting method, etc., it is made into a crepe/paper shape, or a foamed product is made according to the use. [0046] Further, in the case of using a thermosetting resin, a mixture is sufficiently mixed with a stirrer or the like to form a homogeneous mixture. 'Pour it into a mold that is desired to be formed, and then solidify it according to the curing conditions inherent to the selected resin. The antibacterial and antimicrobial compositions of the present invention are useful in a variety of applications. The antibacterial composition of the present invention is an inexpensive and highly safe material unlike conventional silver ion or zinc ion used as an antibacterial agent for plastics, and can be used for a wide range of products including daily necessities. [0049] Therefore, it can be suitably used for articles that are in direct contact with hands or skin. Specifically, it is a keyboard such as a computer, a main body such as a computer tool or a remote controller, a cooking utensil such as a button, a tableware, a cutting board or a metal bowl, a toilet bowl, a floor material or a wall for a bathroom/washroom. Materials, other four-wall materials such as rings or elevators. [0050] Particularly, in the antibacterial product of the present invention, since the antibacterial composition is uniformly distributed in the material and exerts its effect, in the case of being used for, for example, a cutting board, even if the surface of the cutting board is scratched by a kitchen knife, It can fully exert antibacterial properties and maintain antibacterial effects for a long time. [The present invention will now be described in more detail by way of examples, but the invention is not limited thereto. 099101147 Form No. A0101 Page U/Twenty-seventh page 0992002311-0 201124085 [Preparation Example 1 : Preparation of antibacterial composition _] After smashing the shell of scallop, it was simmered at 100 (rc for 1 hour). Water was added thereto, and after digesting, the obtained calcium hydroxide powder was further pulverized by a pulverizer to obtain a powder having an average particle diameter of 10. The boron oxide was mixed into the mixture to prepare an antibacterial composition. [0054] The composition analysis of the obtained antibacterial composition is shown. [0055] Table 1 - Composition of Antibacterial Composition [0056] Ingredient (Element) Content (% by Weight) ~~~~~~~ Ca(OH)2 ~~~ - —~ C 5.6 S〇3 ~~ ~~ 0.41 -- Na2〇0. 39 ~~ Α1Ω ~~ „-~~~~~~~__ 2 3 0.35 Fe2°3 ~〇?34~~ ~~~ ~~~~ SrO ——---- „,. —————______ 0.20 ....' ΡΛ ' ----------- f 0. 14 > MgO 0. 11 B2° 3 '-" I, ------- 0. 11 Example 1: Antibacterial test 1 "~~--- [0058] [0058] 099101147 [Preparation of test piece (antibacterial product) (1 The above antibacterial composition is in an amount relative to the total amount of polypropylene (K02% by weight, 0.5% by weight, 丨·〇 weight) 2. Q% by weight or 2% by weight of the mixture, and a test piece having a size of about 5 〇 with X 40 _ and a thickness of 2-3 mm. Form No. A0101 Page 12 of 27 0992002311-0 201124085 [0059] [0061] [Antibacterial Test and Results] According to JIS Ζ 2801:2000 "Antibacterial Processed Products - Antibacterial Test Method Antibacterial Effect" 5. 2 Test methods for plastic products, etc., manufactured according to the above The test piece (test piece 1 - test piece 5) to which the antibacterial composition was added was subjected to an antibacterial test. The surface of the prepared 5 test pieces and the unprocessed polyethylene film was wiped with ethanol and sufficiently dried, and 0.3 mL was inoculated. The bacterial solution of any of the three strains described below was covered with a polyethylene film, and cultured at 35 ° C for 24 hours (relative humidity of 90%), and the number of bacteria in the bacteria was measured. The summary of the coating film and the bacterial liquid is shown in Table 2, and the results of measuring the number of bacteria after 24 hours of cultivation are shown in Table 3. In addition, photographs of the results of the bacterial culture of the test piece 5) and the unprocessed test piece are shown in the first. Figure - the third picture

099101147 Form No. A0101 Page 13 of 27 0992002311-0 201124085 C〇〇63] Table 2 - Summary of test piece, coated film, and bacterial solution

Classification Antibacterial processing Aseptic processing test piece type test piece 1)-5)*1 Polyethylene film size about 50 mm X 40 Coffee approx. 50 mm X 40 ram Shape Rectangular rectangular thickness about 2-3 mm About 0. 09 ram Covered film type The raw polyethylene film is about 40 mm X 30 mm in shape and has a rectangular shape thickness of about 0. 09 ram bacteria liquid ί2 intake Escherichia coli 0. 3 mL Staphylococcus aureus 0. 3 mL Escherichia coli (0157: Η7) 0. 3 The number of bacteria in the mL solution was 8. ExlOVmL Staphylococcus aureus 6. 6xl〇VmL Escherichia coli (0157: Η7) 7. OxlOVmL * 1 : Test piece 1) - Test piece 5) [0064] 1) Adding an antibacterial combination 02%% of the polypropylene resin sheet containing the antibacterial composition 0. 02%

[0068] 2) a polypropylene resin sheet to which an antibacterial composition is added 3) a polypropylene resin sheet to which an antibacterial composition is added 4) a polypropylene resin sheet to which an antibacterial composition is added 5) an antibacterial combination is added Polypropylene resin sheet 2. 99% Containing antibacterial composition 0. 5% Antibacterial composition 1. 0% Antibacterial composition 2. 0% Antibacterial composition 099101147 Form No. A0101 Page 14 of 27 0992002311 -0 201124085 [0069] *2: bacteria contained in bacterial liquid [0070] Escherichia col i [0071] Staphylococcus aureus: Staphy 1 aureussub-sp. AureusNBRC 12732 [0072] Escherichia coli (serotype 0157) : H7, a non-Shiga toxin strain) • Escherichia coliATCC 43888 [0073]

Table 3 - Measurement results of the number of test pieces of bacteria. Test sample of the test piece. The number of bacteria per test piece was not processed shortly after inoculation 2. 7x105 Unprocessed 1.6xl07 Escherichia coli 35 2C, culture 24 test piece 3) Test piece 4 after 30 hours <10 test piece 5) <10 Not processed shortly after inoculation 1.5χ106 Unprocessed 6. 2x106 Staphylococcus aureus 35 SC, culture 24 test piece 1) Test piece after 50 hours 3) <10 test piece 4) <10 Test piece 5) <10 Not processed shortly after inoculation 2. 5x105 Unprocessed 6. 8x106 Escherichia coli 0Γ, +立矣9/1 Test piece 1) <10 (0157 : H7) /In δϋέ - Test Sheet 3) <10 'J, machi test piece 4) <10 test piece 5) <10 [0074] As shown in Table 3, the unprocessed test piece (polyethylene film) was cultured at 35 ° C 24 After the hour, all showed the result of bacterial proliferation, but the test piece containing the antibacterial composition of the invention 099101147 Form No. A0101, page 15 / 27 pages 0992002311-0 201124085 1) - test piece 5) - All have excellent antibacterial properties. In particular, it can be clarified by displaying the first to third pictures of the culture results, compared with the unprocessed test pieces (first figure (A), second figure (A), second figure (A)) Sheet 5) (Fig. (B), Fig. 1 (B), and Fig. 2 (B)) exhibited good antibacterial properties against any of the three types of bacteria. Example 2: Antibacterial property test 2 [〇〇76] [Preparation of test piece (antibacterial preparation) (2)] [0077] Antibacterial combination prepared in "Preparation Example 1: Preparation of antibacterial composition" The mixture was mixed with 〇. 2% by weight based on the total weight of melamine to prepare a square test piece having a size of about 45 mm X 45 mm and a thickness of 2. [〇〇78] [Antibacterial Test and Results] As described above, the test piece was subjected to an antimicrobial test in accordance with the JIS Z 2801:2000 test method. [0080] Immediately after the surface of the test piece 6) and the unprocessed polyimprint film produced by the test, the substrate was inoculated with ethanol and inoculated with 0.4 ml of the bacterial solution containing any of the two strains described below. Cover the polyethylene film at 35. (3 times, after culturing for 24 hours (relative humidity: 90%), the number of bacteria in the bacteria was measured. [0081] The test pieces, the coated film, and the bacterial liquid used are summarized in Table 4, and the bacteria after 24 hours of cultivation were used. The number measurement results are shown in Table 5. 099101147 Form No. A0101 Page 16 of 27 201124085 [0082] [0084] [0085] [0086] [0088]

Table 4 - Test sheet, coated ^ ^ film, bacterial liquid volume _ classification antibacterial processing aseptic plus test piece type test piece 6) -9)" polyethylene thin _ dust _ size about 45 coffee X 45 mm about 45 coffee X 45 tom shape roughly square roughly square seat a thickness about 2_ wake up about 0. 01 shirt coated film type unprocessed polyethylene film size about 35 ram X 3_5 mm shape roughly rectangular _____ thickness about 0.1 mm bacteria liquid β intake large intestine Bacillus 0. 4 mL Staphylococcus aureus 0. 4 mL Bacterial bacteria in the bacterial cell E. coli 3.5xl 〇 VmL Staphylococcus aureus 5. 8xl05 / mL *1: test piece 6)

The melamine resin sheet of the antibacterial composition contains the antibacterial composition 0.2% *2: the strain contained in the bacterial liquid Escherichia coli:

Escherichia coliATCC 8739 Golden Yellow _ : Staphy1ococcus aureusATCC 6538 Table 5 - Measurement Results of Test Bacteria

大胜棹_ Test strips Staphylococcus aureus 35SC shortly after inoculation, cultured for 24 hours, 35eC shortly after inoculation, unprocessed untested test pieces after 24 hours of culture 6) Unprocessed unprocessed test pieces 6) Number of bacteria per test piece 1.6 X10s 1.3xlQ7 <10 2.0xl05 3. 2x105 <10 099101147 Forms of the public A〇l〇1 Page 17 of 27 0992002311-0 201124085 (1)089] As shown in Table 5, the unprocessed test piece (poly B Women's film) at 3 5 . (3) After the culture was carried out for 24 hours, all of the bacteria were proliferated. However, the sigmoid sheet 6 containing the antibacterial composition of the present invention exhibited excellent antibacterial properties against either of the two bacteria. [0〇9〇] Example 3: pH test and test result of water extract [0091] Test piece prepared from Example 1 [Preparation of test piece (antibacterial product) (1)] (will be added relative to A test piece of 抗菌2% by weight of the total weight of the polypropylene as a sample) was cut to a size of 10 mm X 10 _ to make a test piece 7). The pH of the water extract of the test piece 7) was measured in accordance with JIS K 7371:2000 "Measuring method for measuring the p Η value of the plastic condensed polyethylene homopolymer and the copolymer-water extract". [0093] The pH of the water extract was determined to be 8.1, and the value was in the range of 5.8 to 8.6 of the pH value of the tap water, thereby determining that even if the antibacterial article of the present invention is used for the case of utensils or tableware, It is safe. Example 4: Mechanical physical property test and scale measurement result [〇〇95] As in Example 1 [Preparation of test piece (antibacterial product) (1)], "Preparation Example 1: Preparation of antibacterial composition" 5重量%, 2. 0重量%, 2. 5重量百分比或2. 99重量。 The weight of the total weight of the polypropylene relative to the total weight of the polypropylene is 0.5% by weight, 1.0% by weight, 1. 5重量%, 2. 0% by weight, 2. 5重量% or 2.99 weight % mixing, making a rectangular test piece 8)-test piece 13) having a size of approximately 50 mm X 40 mm and a thickness of 2-3 mm. A test piece without the added antimicrobial composition was prepared as a control. [0096] The prepared test piece was subjected to a softening point temperature test, an impact test, and a flow. 099101147 Form No. A0101 Page 18/27 pages 0992002311-0 201124085 Sexual test 'This is used to evaluate the mechanical physical properties of the test piece [0097] The measuring devices used in the evaluation of physical properties are shown in Table 6, and the results obtained are shown in Table 7. Table 6 - Measurement Devices [0099] Measurement Items Measuring Instruments * _ VI CAT Softening Point Temperature Test

Charpy Impact Test HDT VICAT Tester Measurement Conditions -------- —___ Measurement Load 5kg Impact Tester ❹ [0100] [0101] Hammer 15 J (With Melt Flow Rate Test Melt Indexer F-F01 51 (1) All products manufactured by Toyo Seiki Machinery Co., Ltd. Table 7 - Evaluation results of mechanical and physical properties

Measuring load 2. 16 kg 'Measurement temperature 230 °C 〇 Test piece w Control (no addition) VICAT softening point temperature (°C) 103.1 Charpy impact test (KJ/m2) 7——————--- 3. 1 Melt flow rate (g/ΙΟ minutes 10.9 test piece 8) ------ 105. 3 3. 2 10. 7 Test piece 9) ----- 103. 1 3. 2 10. 2 Test piece 10) "106. 4 3. 2 10. 2 Test piece 11) 105. 5 3. 2 9. 9 Test piece 12) 105. 7 3. 2 9. 7 Test piece 13) -----__ : buckle, ...u 〇, 105. 7 3. 2 9.5 *单·编号 A0101 Page 19 of 27 099101147 0992002311-0 201124085 [0102] 8) Polypropylene resin sheet containing antibacterial composition contains antibacterial composition0 5% [0105] 5% [0105] The polypropylene resin sheet containing the antibacterial composition contains the antibacterial composition 1. 5% [0105] 5% [0107] 1 3) Adding an antibacterial combination. The polypropylene resin sheet to which the antibacterial composition is added contains the antibacterial composition 2. 0% [0106] 12) The polypropylene resin sheet to which the antibacterial composition is added contains the antibacterial composition 2. 5% [0107] 1 3) The polypropylene resin sheet containing the antimicrobial composition 2. 99% [0108] As shown in Fig. 7, the results show that the softening point temperature test and the impact test value of the test containing the above-mentioned antibacterial composition are substantially the same as those of the unadded test piece, and the values of the two are The difference can be considered to be within the error range. [0109] In addition, the fluidity decreases with an increase in the amount of the antimicrobial composition added, but the amount of reduction is small compared to the case of no addition, and the fluidity is substantially maintained.

It can be seen that the antibacterial article according to the present invention substantially maintains the same mechanical and physical properties as compared with the test piece without added II. 5 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 The % by weight was mixed to make a cutting board having a size of about 40 cm X 24 cm and a thickness of about 13 mm. [0113] According to the food hygiene law - food / additive and other specifications (Showa 34th, Ministry of Health and Welfare Notice No. 370), polyethylene and polypropylene as the main component of the synthesis 099101147 Form No. A0101 Page 20 / 27 pages 0992002311- 0 201124085 Resin-made appliance, or container packaging (Heisei 18 Ministry of Health, Labour and Welfare Notice No. 201) for material testing (lead 'cadmium) and extraction test (heavy metal (lead), peracid potassium consumption, evaporation residue ( Water, 4% acetic acid '2〇% ethanol, heptane)) According to this, the results show that any of the test results are in line with the food hygiene law, a food m / additive and other specifications, the Showa 34 years of the Ministry of Health and Welfare Notice No. 37) Therefore, it was confirmed that the antibacterial product of the present invention is safe even when used for a cutting board or the like. [Simple Description of the Drawings] 〇 [0114] [0115] [0117] The first figure shows a test piece 5) containing a solution containing Escherichia coli (a polypropylene resin sheet containing 2.99% of the antimicrobial composition) (Photograph of the first figure (8)) and the (unprocessed) test piece (the first figure (1)) containing no antibacterial composition (4), after the time. The second circle is shown in a test piece 5) containing a solution containing Staphylococcus aureus (a polypropylene resin sheet containing 2.99% of the antimicrobial composition) (second figure (8)) and an antibacterial composition (raw) A photograph of the results of the test piece (Fig. 2 (a)) after 24 hours of cultivation. Figure 3A shows a test piece 5) containing a solution containing Escherichia coli (0157:H7) (a polypropylene resin sheet containing 2. "% antibacterial composition) (second figure (10) and without antimicrobial composition ( Unprocessed test piece (photograph of the result after 24 hours of incubation on the third figure (9). [Explanation of main component symbols] None 099101147 Form No. A0101 Page 21 of 27 0992002311-0

Claims (1)

5%以上以上优选优选0. 0. More than 0. 05%, preferably about 0. The total weight of the antibacterial composition is about 0. 05% or more, preferably about 0. 2% or more. The antibacterial composition according to claim 1, wherein the butterfly element in the antibacterial composition is present in the form of boron oxide. 3. The antibacterial composition of claim 2, wherein the composition is in the form of a powder. I. The antibacterial composition of claim 3, wherein the antibacterial composition has an average particle size of from about 0.1 / zm to about 500 / zm, preferably from about 0.5 / zm to about 100 / im, more preferably about 0. 5 # M-40 is m, most preferably about 0.5 / zm - 10 / zm. The 5% or less, preferably about 0. 4 ° /. The following antibacterial composition is prepared by calcining a shell; adding water to the calcined product to prepare a composition having calcium hydroxide as a main component; adding to the obtained powder The boron element has a boron content of about 0.05%/» or more, preferably about 0.2% or more, based on the total weight of the composition. The antibacterial composition according to claim 6, wherein the hydroxide mother is derived from an animal origin, such as a shell of a scallop, an abalone shell, a conch shell, a surf shell, a sea urchin shell, or the like. Or a coral shell, preferably a scallop shell. The antimicrobial composition according to claim 7, wherein the sole element in the antimicrobial composition is present in the form of boron oxide. 099101147 Form No. A0101 Page 22 of 27 0992002311-0 201124085 The antibacterial grade entry as described in claim 8 exists. / 其中 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 The antibacterial composition as described in claim 8 is more preferably about 0.5 mil, 4 〇 '' ° '5 ^ m ^ l 〇〇 4 〇 最 最 最 最 最 最 最 最 最 最 最 最 最 最 最 最, occupies about 8% of the total weight of the antibacterial composition, δ, ', weaving content. The lower 'preferred about., the following one antibacterial method, including the antibacterial; the application item W1 in the request - Anti-": An antibacterial preparation comprising: about 1〇n n90 weight of thermoplastic 槲 2.99 parts by weight of the desired bismuth and about composition or comprising about 100 weights of the item, the anti-Panwu (four) thermosetting resin and about 0] Any one of the claims 1 of the claim 1 is called the unantibacterial composition. The antibacterial product described above, wherein the antibacterial composition is dispersed in the thermoplastic resin or thermosetting resin in a powder two:: knife. The antibacterial article according to the item 13, wherein the thermoplastic resin is a polyethylene resin, a polypropylene resin, a polystyrene resin, a polystyrene tree, a polyamine resin, a polycarbonate resin, Polycondensation, bismuth (poly(ethylene terephthalate)) resin, bismuth (polybutylene terephthalate) resin and ABS (acrylonitrile-butadiene-styrene) resin. The antibacterial article according to the above item 15, wherein the thermosetting resin is selected from the group consisting of unsaturated polyester resins, epoxy resins, phenol resins, melamine resins, acrylic resins, urea resins, polyimide resins, and oxime resins. The antibacterial article of claim 13 or 14, wherein the thermosetting resin form is edited ίοι Page 23 of 27 0992002311-0 17 . 201124085 is selected from the group consisting of unsaturated polyester resins, Epoxy resin, phenolic resin, melamine resin, acrylic resin, urea resin, polyimidate resin and crushed resin. 099101147 Form No. A0101 Page 24 of 27 0992002311-0