201106920 六、發明說明： 【發明所屬之技術領域】 本發明係與自我健康檢測裝置有關，特別是關於—種 以非侵入式擷取生理資訊之電腦系統。 【先前技術】 有鑒於近年來醫療器材以及健康食品等的養生科技不 斷進步，使得國人平均壽命增加；但是，實際上死亡人口 卻是反增不減。針對衛生署所統計國人十大死因：惡性腫 瘤、腦血管疾病、心臟病、高血壓…等疾病，絕大部分都 無法從健保給付的項目中篩檢出來。深究其因，乃是國人 對於健康檢查並不積極，且全民健保的健檢給付項目僅限 於-般如抽血、驗尿㈣於侵人式雜查方式，至於以非 侵入式之檢魏本較高的項目，例如：超音波、χ光及心 電圖等，並不在給付項目之中；再者，由於超音波、X光 及心電圖之檢查項目㈣且需要特地排定時間，對於 來說並不方便。 冑面上有可供國人自行購得的健康檢查器材 ==一可攜式血氣濃度計10，，係以非侵入式檢 查方式快賴取生理資訊， 值及血脈波_，供使^ 晨度 足夠提供血氧鼓，進>4=檢測是否呼赠得的氧氣 發性肺纖維化等潛藏疾C:吸著迫症候群或特 的測試原理係依據比;7=4中/R血氧飽和濃度 伯特疋律（Beer Lambert’s 201106920201106920 VI. Description of the Invention: [Technical Field of the Invention] The present invention relates to a self-health detecting device, and more particularly to a computer system that non-invasively extracts physiological information. [Prior Art] In view of the continuous advancement of health care technology such as medical equipment and health foods in recent years, the average life expectancy of Chinese people has increased; however, in fact, the death population has increased. In response to the Department of Health's statistics on the top ten causes of death: malignant tumors, cerebrovascular diseases, heart disease, high blood pressure, etc., most of them cannot be screened out from health care payments. The reason for this is that the Chinese people are not active in health checkups, and the health check-ups for the whole people's health insurance are limited to - such as blood draw, urine test (4) intrusive investigation, as for non-invasive inspection of Weiben. Higher projects, such as: ultrasonic, twilight and electrocardiogram, are not in the payment project; in addition, due to the inspection items of ultrasound, X-ray and electrocardiogram (4) and need to be scheduled, it is not Convenience. There are health check-up devices available for purchase by the Chinese people on the face == A portable blood gas concentration meter 10, which is based on non-invasive inspection methods, and relies on physiological information, values and blood waves _, for the morning Sufficient to provide blood oxygen drum, enter > 4 = detect whether you are giving away oxygen-borne pulmonary fibrosis and other hidden diseases C: stimuli syndrome or special test principle based on ratio; 7 = 4 / R oximetry Concentration Burt's Law (Beer Lambert's 201106920
Law)’由於心臟的跳動會弓丨起主動脈的彈性舒張與收縮而 运出具有規律波狀血觀至顿脈，故崎測設備輸出 兩個不同波長的光訊號穿透人體内部組織，可因血墨波所 導致_舒張和收縮㈣響穿透光的強度；因此組織中血 流與=氧、不帶氧血紅素的改變，會對光訊號的吸收度不 同’量測兩種*同成分光線的歧收度即可推算血和 濃度。 縱然上述可攜式血氧濃度計10,藉由附掛於使用者手 腕上’可將脈搏的跳動轉換為心跳值及血脈波圖形輸出； =而，對於一般使用者而言，心跳數值僅得參考是否於正 常每分鐘之心跳數，亦無法單純由血脈波圖形，而分析出 與脈搏相關的人體健康資訊以進—步判斷是否有其他潛藏 疾病的了此。實則上，脈搏的振動強弱、快慢等是中醫在 為病人診病時重要的依據，所量測的脈動可如第五圖所示 取得週期性振動波’如同上述可攜式血氧濃度計1〇，所輪 出之血脈波圖形，圖中粗線為一週期性的振動波，内部包 含不同頻率與不同振幅的小波(如細線與虛線表示）；若從 此波動圖的外觀’只可看見它只是—種連續大的波動波' 如果不經過分析，其内部有多少不同頻率及其振幅大小都 無法從外觀得知。 脈搏振動波與自主神經活性的關係十分密切，以交感 神經為例，放電頻率為低頻波段(0〜10Hz)時，是維持血二 基本的功能運作，而高頻波段(10Hz以上)之高頻頻率平^ 活性較小，一旦生病或人體受到刺激時，神經活性會升高， 201106920 造成10Hz以上之高頻頻率放電增加。因此 病時其 =::波經㈣轉換 不门=的波動，u及這些不同頻率波的振幅高低。 、二人體心臟每分鐘約跳動72次，這稱之為平均 跳所間隔的時間與平均每次心跳週期 • V 4的標準偏騎為轉變異（Η 差約為40毫秒；上诚可媸斗丄片、曲由 丹知+褐 上述了攜式血軋濃度計10’僅得輸出心跳 數值’、〜、法作為偵測心率變異之用。目前，已知心率變 異與心跳有關’而且心臟除了本身的節律性放電引發的跳 動之外’也受到自律神經系統(Aut〇n〇mk nerv〇us挪⑽， ANS)所調控，這也就意味著心率變*、自律神經和心跳這 二者有密不可分的關係。心率變異代表自律神經總活性； 自律微調功&越好，越高。而心率卻會受到人體的自 律神經系統所影響，自律神經系統包括交感神經系統和副 父感神經系統，前者可使心率上升，後者則使心率下降， 心率就在二者交互作用下產生最佳的平衡狀態。在過去的 一十年中已有不少文獻顯示自律神經的調控與心血管疾病 相關的死亡率有顯著的關係，例如：心因性猝死、高血壓、 出企性休克等，而心率變異分析亦被發現可作為預測發生 心肌梗塞後的死亡率的指標。 201106920 2006年工程科技與中西醫學應用研討會中，孫德銓等 人即提出一種「新型腕式生理監視器_心律大師之簡介及其 中西醫學應用為以屬電感應器感應血壓波之特性，而輸 出結合▲塵、脈象及HRV分析之非侵入式生理監視器。然 而以該腕式生難視器之感應及處理功_言，當心率變 異的分析魏僅顯示於某項生理量測數值上，雖說也有可 觀察疋否有潛藏病徵存在的警訊魏，但是侧注單一項 數值時，往往會因為外在因素而使數值會暫時性的失準， 例如.清緒的激動與否、是否有受到外在的刺激影響 等，無法由其它方面同時間一起做比較。 由於上述罹病好發族群之中，以電腦使用者佔多數； 故本發明人構思藉由提供多種健康檢測功能，將非侵入式 檢測裝置整合於-般大幕需要長時間接觸的電腦週邊設 備，並以精確的電路處理將多項生理資訊輸出，以希望在 使用者操作電腦關時，也能夠即時自我監測身體狀態， 進而及早發現身體警訊，以免延誤就醫時機。 【發明内容】 本發明之主要目的在於提供一種擷取生理資訊之電腦 系統，其能夠於使用者操作電腦期間，進一步反映使用者 的身體狀態，具有提供使用者自我檢測身體狀態之特色。 為達成上述目的，本發明所提供一種擷取生理資訊之 電腦系統，其能夠於使用者操作電腦裝置期間，於握持滑 鼠時進一步反映使用者的身體狀態。該電腦系統之一滑鼠 201106920 主體裝設有二發光體可對使用者手指動脈投射不同波長之 光束’滑鼠主體中另設有一光感測器可接收由動脈反射之 不同波長之光束而取得不同之一第一及一第二信號；與該 光感測器電性連接有一放大電路，可先後將該第一及第二 信號濾除直流偏壓、可見光雜訊及電源雜訊，並取出第一 及第二信號中的變化量。 因此電腦裝置可透過一類比/數位轉換器（A/D 鲁 converter)接收分別對應於該第一及第二信號並處理為數 位訊號，進而分類成三部分；第一部分是推算血氧濃度， 需要該第一及第二光束穿透人體内部組織時因血壓波所導 致組織舒張和收縮而造成的光吸收度，以進行血氧飽和濃 度運算；第二部分是以快速傅立葉轉換進行脈搏頻譜分 析，將動脈反射波的時域轉成頻域，且運算後再做譜能量 比(Spectral Energy Ratio, SER)的方法來分析自主神經活 性；第三部分則是產生心跳頻率以及運算心率變異加⑽ • rate variability; HRV)。這三部分分類、運算完後即可顯示 出多項生理資訊。當使用者身體出現問題且不自覺的情形 下，該電腦系統能夠根據該生理資訊提出預警，用以罄示 使用者就醫甚至做更進一步的檢查；本發明相較於習知 者，具有提供使用者自我檢測身體狀態之特色。 【實施方式】 為了詳細說明本發明之結構、特徵及功效所在’茲舉 以下較佳實施例並配合圖式說明如後，其中： 201106920 第:圖為本發明第—較佳實施例之架構示意圖。 第=圖為本發明第一較佳實施例之電路方塊圖。 第三圖為本發明第-較佳實施例之動作流程圖，主要 揭不電腦裝置的運作情形。 吻參閱第-圖至第三圖，本發明第一較佳實施例所提 供擷取生理資訊之電腦系統⑽，包含有—滑鼠主體(2〇)、 第發光體(30)、-第二發光體(4〇)、_光感測器(5〇)、 二放大電路(6G)、-類比/數位賴離如㈣伽調、 一傳輸介面(80)以及一電腦裝置(90)，其中： 该滑鼠主體(20)係藉由該傳輪介面㈣裝設於電腦農 置(90)之周邊，供使用者握持以操作電腦裝置㈣之營幕游 標(91) 〇 該第一及第二發光體(3〇、4〇)設於該滑鼠主體(2〇)，分 別產生不同波長之—第—及—第二光束(則、樹)以對人 體手指動脈投射。該第一光束的波長範圍4 _趣至 OOnm’ j帛—光束的波長較佳者為_伽，·本實施例中， 該第一光束的波長以660nm為例，在此僅為舉例說明，並 非做為限制要件。該第二絲的波長範圍為請⑽至 〇〇〇nm，5亥第二光束的波長較佳者為940nm ;本實施例 中’該第二光束的波長以94〇nm為例，在此僅為舉例說明， 並非做為限制要件。 t該光感測器（50)設於該滑鼠主體(20)，接收經由人體手 指動脈將該第-及第二光束反射之—第—及—第二反射光 201106920 束(302、402)，因而分別產生一第一及一第二信號。 該放大電路(60)係電性連接該光感測器，可同樣設於 該滑鼠主體(20)内部或如本實施例所例舉之額外裝設於該 滑鼠主體(20)上’以放大濾波處理該第一信號以及該第二 信號；該放大電路(60)具有一二階高通濾波器(61)、一增益 放大器(63)、二相互串接之二階低通濾波器（65)、一微分器 (67)以及一反相放大器(69)。其中，高通濾波器(61)之輸入 端電性連接該光感測器（50)，輸出端電性連接該增益放大 器（63);低通濾波器（65)之輸入端電性連接該增益放大器 (63)，輸出端電性連接該微分器(67);反相放大器（69)之輸 入端電性連接該微分器（67) ’輸出端電性連接該類比/數位 轉換器(70)。 配合第二圖參照，該第一及一第二信號先經過該二階 南通濾波器(61)，目的是為了去除手指晃動所形成的漂移 電壓以及光耗合器的直流偏壓，以確保下一級電路不至於 進入飽和區而無法正常運作；通過高通濾波器（61)後，訊 號輸入至增益放大器（63)放大訊號，以利於下一級電路的 檢測；然後訊號進入二相互串接之二階低通濾波器（65)， 其目的是為了分別去除日光燈所產生的可見光雜訊和來自 電源之高頻雜訊；之後訊號進入微分器（67)凸顯前級訊號 的變化量，以便觀察訊號内部的變化，因前級二階高通濾 波器(61)得以去除直流偏移電壓，可有效避免直流效應造 成微分器（67)之運算放大器進入飽和區使得微分器（67)不 月匕正吊工作；接著再把訊號輸入至反相放大器（69)，因為 201106920 微分器（67)會造成訊號iso。的改變，因此須經過反相放大器 (69)將訊號恢復為原來的相位。 該類比/數位轉換器（70)之輸入端電性連接反相放大器 (69)，輸出端電性連接該傳輸介面(80)，該類比/數位轉換 器（70)用以將類比訊號轉換為與該傳輸介面(8〇)的訊號傳 輸規格相符之數位訊號，可同樣設於該滑鼠主體(2〇)内部 或如本實施例所例舉之額外裝設於該滑鼠主體(2〇)上；本 實施例中，該傳輸介面(80)係為USB介面，在此僅為舉例 δ兒明，並非做為限制要件。因此該第一及一第二信號經過 以上放大電路(60)後，再由該類比/數位轉換器（7〇)轉換為 數位形式之一第一及一第二數位訊號以傳輸至該傳輸介面 (80)。 配合第三圖參照，該第一及第二數位訊號傳送至電腦 裝置(90)後，即由電腦裝置(90)中安裝的軟體處理分類成三 部分；第一部分是血氧濃度，需要推算該第一及第二光束 (301、401)穿透人體内部組織，因血壓波所導致組織舒張 和收縮而造成的光吸收度，以推算血氧飽和濃度運算；第 二部分則是快速傅立葉轉換，將脈動的時域轉成頻域且其 運鼻後的結果’需再做谱能量比（Spectrai Energy Ratio, SER)的方法來为析，第二部分則是產生心跳頻率以及運算 心率變異(heart rate variability ; HRV)。這三部分分類、運 鼻元後’再由軟體之顯不介面顯示出多項生理資訊(92， 94 ’ 96 ’ 98);該等生理資訊(92，94，96，98)的類型分別 為心跳頻率、血氧飽和濃度、自主神經活性以及心率變異 201106920 分析；本實施例中’該生理資訊_型，在此僅為舉例說 明’並非做為限制要件。其中，該生理資觸推演原理如 下： 一 ·該生理資訊(9 2 )為心跳頻率者，其係經由監測 該第一信號與該第二信號於時域上的表現，即可得知。 二.該生理資訊(94)為血氧飽和濃度者，由於血液 中帶氧血紅素以及不帶氧血紅素的比例會使人體組織 層對於光線產生不同的吸收度，進而影響該第—光束 以及該第二光束的反射強度的特性。由於該第一光束 以及該第二光束使用不同的波長，該第一信號以及該 第二信號則能夠分別在十對帶氧血紅素以及不帶氧血紅 素的比例特徵加以顯現；經由處理該第一及第二信號 而對應之第-及-第二數位訊號分別推演計算人體組 織層對於該第-光束以及該第二光束的吸收度，用以 達到偵測血氧飽和濃度之目的。 二.該生理資訊(96)為關於自主神經活性之脈搏 頻"曰刀析者，其係將该第一信號或該第二信號經由快 速傅立葉運算(fast foudef tfansfer ; FFT)，以將脈搏由 時域轉換為頻域轉辨譜(p。而Spe⑽，分解成直 原來組成的分立頻譜；再經由譜能量比(啊耐 ratio，SER(/))運算推演，其公式為娜⑺=尽⑺&⑺， ，中/為特定的頻率’ A⑺為/Hz以下综合譜的能 為/ Hz以上綜合譜的能量。因此，低頻(〇〜ι 〇Hz) 能量與高頻（10Hz以上)能量比卿〇) = ι〇〇可以做為區 201106920 別正常人與病人的指標，正常人证Λ(ι〇)值大於1⑻以 上，而病人证ζψο)則小於100。同時，由正常人证大 於100推算出正常人脈波頻譜的能量超過99 1%集中在 10Hz之前，而生病時由证Λ(1())與頻譜圖可知ι〇Ηζ以 上的頻譜能量會增加，造成10Ηζ以上頻譜的變動。 四.該生理資訊(98)為心率變異分析者，其係經由 監測每次心跳之間的間隔時間，再與正常心跳值進行 比對而得知’亦即為該第—錄或該第二信號之時域 間隔與其時域週期之差值。 — 病灶 經由上述結構，本發明所提供擷取生理資訊之電腦系 統(10)，其能夠於使用者操作滑鼠期間，以非侵入式自我 健康檢測，進-步反映使用者的身體狀態，顯示/人體的 心跳頻率、血氧飽和濃度、自主神經活性以及心率變異分 析四項數值’提供使用者交m _自讀康狀況1 否正常，相較其他產品較能提供多樣的資訊。換古之，本 發明把中醫的脈診科學化，將關得的脈搏，由·性的 振動波_傅立葉轉換後㈣轉物域，靖頻譜做分 析’告訴使用者其身體是否微恙，做為就醫的重要依據。 當身體出關題且於使騎不自覺的情形下，該電腦系統 (10)能夠根據該生理資訊並經由該電腦裝置(90)連社其他 周邊設備或裝設其聽錄體岐用麵出糾，:以盤 示使用者可能㈣問題；藉以達到讓使用者能夠及時ς 醫’或者做更進-步的檢查’用以進—步瞭解身體狀況或 201106920 綜上所陳，本發明於前述實施例中所揭露的構成元 件，僅為舉例說明，並非用來限制本案之範圍，其他等效 元件的替代或變化，亦應為本案之申請專利範圍所涵蓋。Law) 'Because the beating of the heart will bow the elastic relaxation and contraction of the aorta and send out the regular wavy blood to the vein, the barometric device outputs two different wavelengths of light to penetrate the internal tissues of the human body. The intensity of the transmitted light caused by the blood wave wave _ diastolic and contraction (four); therefore, the blood flow in the tissue and the change of oxygen and non-oxygen hemoglobin will have different absorbance of the optical signal. The blood and concentration can be estimated by the difference in the composition of the light. Even if the portable oximeter 10 is attached to the wrist of the user, the pulse beat can be converted into a heartbeat value and a blood wave graphic output; = for the average user, the heartbeat value is only obtained. Refer to whether the number of heartbeats per minute is normal, and it is not possible to analyze the pulse-related human health information simply by the blood wave pattern to further determine whether there are other hidden diseases. In fact, the pulse vibration intensity, speed, etc. are important basis for Chinese medicine in the diagnosis of patients. The measured pulsation can obtain periodic vibration waves as shown in the fifth figure. Like the above portable oximeter 1 〇, the blood wave pattern that is rotated, the thick line in the figure is a periodic vibration wave, and the inside contains wavelets with different frequencies and different amplitudes (such as thin lines and dashed lines); if the appearance of the wave pattern is only seen from it It's just a continuous wave of fluctuations'. If not analyzed, how many different frequencies and their amplitudes are not known from the appearance. The relationship between pulse vibration wave and autonomic nerve activity is very close. Taking sympathetic nerve as an example, when the discharge frequency is low frequency band (0~10Hz), it is the basic function of maintaining blood, and the high frequency band (above 10Hz) The frequency is flat ^ activity is small, once the disease or the human body is stimulated, the nerve activity will increase, and 201106920 causes the high frequency frequency discharge above 10Hz to increase. Therefore, when it is sick, its =:: wave (4) conversion, the fluctuation of the door, and the amplitude of the waves of these different frequencies. The human heart beats about 72 times per minute. This is called the average hop interval and the average heartbeat cycle. The standard eccentricity of V 4 is different (the difference is about 40 milliseconds; Bracts, songs by Dan Zhi + brown The above-mentioned portable blood concentration meter 10' only has to output heartbeat values ', ~, method for detecting heart rate variability. Currently, heart rate variability is known to be related to heartbeat and heart The beating of the rhythmic discharge itself is also regulated by the autonomic nervous system (Aut〇n〇mk nerv〇us (10), ANS), which means that heart rate changes, autonomic nerves and heartbeats have Inseparable relationship. Heart rate variability represents the total activity of autonomic nerves; self-regulation and fine tuning & better and higher. The heart rate is affected by the autonomic nervous system of the human body, including the sympathetic nervous system and the parasitic nervous system. The former can increase the heart rate, the latter will lower the heart rate, and the heart rate will produce the best balance under the interaction of the two. In the past decade, many literatures have shown that the regulation of autonomic nerves There is a significant relationship between mortality associated with cardiovascular disease, such as sudden cardiac death, high blood pressure, and shock, and heart rate variability analysis has also been found to be an indicator of mortality after myocardial infarction. In the 2006 Engineering Technology and Chinese and Western Medicine Application Seminar, Sun Dejun and others proposed a new type of wrist physiological monitor _ heart rhythm master and its Chinese and Western medical applications to induce blood pressure waves by electric sensors, and the output combination ▲ dust, pulse and HRV analysis of non-invasive physiological monitors. However, the induction and processing of the wrist-type refractory device, when the analysis of heart rate variability is only shown on a physiological measurement value, although There are also police officers who can observe whether there are hidden symptoms. However, when a single value is used, the value will be temporarily misaligned due to external factors, such as whether the Qingxu is excited or not. External stimuli, etc., cannot be compared at the same time by other parties. Because of the above-mentioned rickets, computer users account for the majority; The inventor conceived that by providing a variety of health detection functions, the non-invasive detection device is integrated into a computer peripheral device that requires long-time contact, and a plurality of physiological information is outputted by precise circuit processing, so as to be operated by the user. When the computer is turned off, it is also possible to self-monitor the body state immediately, and then discover the body alarm early, so as not to delay the medical treatment opportunity. [Invention] The main object of the present invention is to provide a computer system for extracting physiological information, which can be operated by a user. During the computer, the user's physical state is further reflected, and the user is provided with the self-detecting physical state. To achieve the above object, the present invention provides a computer system for extracting physiological information, which can be used by the user during operation of the computer device. It further reflects the user's physical condition when holding the mouse. One of the computer systems, the mouse 201106920, is equipped with two illuminators to project different wavelengths of light to the user's finger artery. 'There is another light sensation in the mouse body. The detector can receive beams of different wavelengths reflected by the artery Obtaining one of the first and second signals; electrically connecting the optical sensor with an amplifying circuit, and filtering the first and second signals to remove DC bias, visible light noise, and power noise, respectively, and The amount of change in the first and second signals is taken out. Therefore, the computer device can receive the digital signals corresponding to the first and second signals and process them into three parts through a type of analog/digital converter (A/D Lu converter), and then classify into three parts; the first part is to calculate the blood oxygen concentration, and the need The light absorption caused by the relaxation and contraction of the tissue caused by the blood pressure wave when the first and second light beams penetrate the internal tissue of the human body to perform the blood oxygen saturation concentration calculation; the second part is the pulse spectrum analysis by the fast Fourier transform, The time domain of the arterial reflected wave is converted into the frequency domain, and the Spectral Energy Ratio (SER) method is used to analyze the autonomic nerve activity; the third part is to generate the heartbeat frequency and calculate the heart rate variability plus (10). Rate variability; HRV). After the three parts are classified and calculated, a number of physiological information can be displayed. When the user's body is in a problem and is unconscious, the computer system can provide an early warning based on the physiological information to indicate that the user seeks medical treatment or even further checks; the present invention has a use as compared with the prior art. Self-testing the characteristics of the body state. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS In order to explain the structure, features and functions of the present invention in detail, the following preferred embodiments are described with reference to the accompanying drawings, wherein: . Figure 1 is a block diagram of a circuit in accordance with a first preferred embodiment of the present invention. The third figure is a flow chart of the action of the first preferred embodiment of the present invention, which mainly reveals the operation of the computer device. Kiss, referring to the first to third figures, a computer system (10) for extracting physiological information according to a first preferred embodiment of the present invention includes a mouse body (2〇), a first illuminant (30), and a second Illuminant (4〇), _photo sensor (5〇), two amplifier circuit (6G), analog/digital, such as (four) gamma, a transmission interface (80), and a computer device (90), wherein : The mouse body (20) is installed around the computer farm (90) by the wheel interface (4) for the user to hold the operating device (4) the operating cursor (91). The second illuminator (3〇, 4〇) is disposed on the main body of the mouse (2〇), and generates a second-wavelength (thus, a tree) of different wavelengths to project a finger artery of the human body. The wavelength range of the first beam is 4 _ interesting to OOnm' j 帛 - the wavelength of the beam is preferably _ gamma, in this embodiment, the wavelength of the first beam is 660 nm, for example, Not as a limiting element. The wavelength of the second wire is from (10) to 〇〇〇nm, and the wavelength of the second beam is preferably 940 nm. In the present embodiment, the wavelength of the second beam is 94 〇 nm, and only For the sake of illustration, it is not intended as a limitation. The photo sensor (50) is disposed on the mouse body (20), and receives the first and second light beams reflected by the human finger artery - the second and second reflected light 201106920 (302, 402) Thus, a first and a second signal are generated, respectively. The amplifying circuit (60) is electrically connected to the photo sensor, and may be disposed inside the mouse body (20) or additionally mounted on the mouse body (20) as exemplified in the embodiment. The first signal and the second signal are processed by amplification filtering; the amplifying circuit (60) has a second-order high-pass filter (61), a gain amplifier (63), and a second-order low-pass filter (65) connected in series with each other. ), a differentiator (67) and an inverting amplifier (69). The input end of the high-pass filter (61) is electrically connected to the photo sensor (50), and the output end is electrically connected to the gain amplifier (63); the input end of the low-pass filter (65) is electrically connected to the gain An amplifier (63), the output end is electrically connected to the differentiator (67); the input end of the inverting amplifier (69) is electrically connected to the differentiator (67) 'The output end is electrically connected to the analog/digital converter (70) . Referring to the second figure, the first and second signals first pass through the second-order south pass filter (61), in order to remove the drift voltage formed by the finger shake and the DC bias of the light consumable to ensure the next level. The circuit does not enter the saturation region and cannot operate normally. After passing through the high-pass filter (61), the signal is input to the gain amplifier (63) to amplify the signal to facilitate the detection of the next-stage circuit; then the signal enters the second-order low-pass connected to each other. The filter (65) is designed to remove the visible light noise generated by the fluorescent lamp and the high frequency noise from the power supply respectively; then the signal enters the differentiator (67) to highlight the change of the previous signal to observe the change inside the signal. Because the pre-stage second-order high-pass filter (61) can remove the DC offset voltage, the DC effect can be effectively avoided, and the op amp of the differentiator (67) enters the saturation region so that the differentiator (67) does not hang the crane; The signal is input to the inverting amplifier (69) because the 201106920 differentiator (67) causes the signal iso. The change is made, so the signal must be restored to its original phase via the inverting amplifier (69). The input terminal of the analog/digital converter (70) is electrically connected to the inverting amplifier (69), and the output terminal is electrically connected to the transmission interface (80), and the analog/digital converter (70) is used to convert the analog signal into The digital signal corresponding to the signal transmission specification of the transmission interface (8〇) can be similarly disposed inside the mouse body (2〇) or additionally installed in the mouse body as exemplified in the embodiment (2〇) In the embodiment, the transmission interface (80) is a USB interface, which is merely an example of the definition, and is not intended to be a limitation. Therefore, after the first and second signals pass through the above amplifying circuit (60), the analog/digital converter (7〇) converts the first and second digital signals into a digital form for transmission to the transmission interface. (80). Referring to the third figure, after the first and second digital signals are transmitted to the computer device (90), the software processing installed in the computer device (90) is classified into three parts; the first part is the blood oxygen concentration, which needs to be calculated. The first and second light beams (301, 401) penetrate the internal tissue of the human body, the light absorbance caused by the relaxation and contraction of the tissue caused by the blood pressure wave, to calculate the blood oxygen saturation concentration; the second part is the fast Fourier transform, The pulsating time domain is converted into the frequency domain and the result after the nose is 'required by the Spectrai Energy Ratio (SER) method. The second part is to generate the heartbeat frequency and calculate the heart rate variability (heart). Rate variability ; HRV). The three parts of the classification, after the nose of the nose, and then the software interface shows a variety of physiological information (92, 94 '96 '98); the types of physiological information (92,94,96,98) are heartbeat Frequency, blood oxygen saturation concentration, autonomic nerve activity, and heart rate variability 201106920 analysis; in this embodiment, 'the physiological information _ type, which is merely an example here' is not a limiting element. The physiological resource tacting principle is as follows: 1. The physiological information (9 2 ) is a heartbeat frequency, which is known by monitoring the performance of the first signal and the second signal in the time domain. 2. The physiological information (94) is a blood oxygen saturation concentration, because the proportion of oxygenated hemoglobin and non-oxygen hemoglobin in the blood causes the human tissue layer to have different absorption for light, thereby affecting the first beam and The characteristic of the intensity of the reflection of the second beam. Since the first light beam and the second light beam use different wavelengths, the first signal and the second signal can be respectively displayed in a proportional characteristic of ten pairs of oxygenated heme and no hemoglobin; The first and second signals corresponding to the first and second signals respectively calculate the absorption of the first light beam and the second light beam by the human tissue layer for the purpose of detecting the blood oxygen saturation concentration. 2. The physiological information (96) is a pulse frequency for autonomic nerve activity, which is to pass the first signal or the second signal via a fast foudef tfansfer (FFT) to pulse From the time domain to the frequency domain to the spectrum (p. and Spe (10), decomposed into the original discrete spectrum; and then through the spectral energy ratio (ah resistance ratio, SER (/)) operation, the formula is Na (7) = do (7) & (7), , Medium / is the specific frequency 'A (7) is / Hz The spectrum of the integrated spectrum can be the energy of the integrated spectrum above / Hz. Therefore, the low frequency (〇 ~ι 〇Hz) energy and high frequency (above 10Hz) energy ratio Qing 〇) = ι〇〇 can be used as an indicator of the normal person and patient in the district 201106920, the normal person's card (ι〇) value is greater than 1 (8), and the patient's card ζψ )) is less than 100. At the same time, the energy of the normal human pulse wave spectrum is more than 99 1% from the normal person's card to be concentrated before 10 Hz. When the disease is sick, the spectrum energy above ι〇Ηζ is increased by the syndrome (1()) and the spectrogram. Causes changes in the spectrum above 10Ηζ. 4. The physiological information (98) is a heart rate variability analyzer, which monitors the interval between each heartbeat and compares it with the normal heartbeat value to know that 'the first record or the second The difference between the time interval of the signal and its time domain period. - The above-mentioned structure, the computer system (10) for extracting physiological information is provided by the present invention, which can reflect the physical state of the user in a step-by-step manner during non-invasive self-health detection during the operation of the mouse. / The human body's heart rate, blood oxygen saturation concentration, autonomic nerve activity and heart rate variability analysis four values 'provide users to pay m _ self-reading health condition 1 is normal, compared with other products can provide a variety of information. In the past, the invention scientifically diagnosed the pulse diagnosis of Chinese medicine, and cut the pulse from the vibration wave _ Fourier transform (four) to the object domain, and analyze the spectrum to tell the user whether the body is slightly sloppy or not. An important basis for medical treatment. When the body issues a problem and the ride is unconscious, the computer system (10) can connect to other peripheral devices or install the listening body through the computer device (90) according to the physiological information. Correction: to indicate the user's possible (4) problem; so as to enable the user to promptly seek medical treatment or to perform a further step-by-step inspection to further understand the physical condition or 201106920, the present invention is The constituent elements disclosed in the embodiments are merely illustrative and are not intended to limit the scope of the present invention. The alternative or variations of other equivalent elements are also covered by the scope of the patent application.
13 201106920 【圖式簡單說明】 第-圖為本發明第一較佳實施例之架構示意圖； 第二圖為本發明第一較佳實施例之電路方塊圖；’ 第三圖為本發明第一較佳實施例之動作流程圖 揭示處理裝置的運作情形； 主要 第四圖為習用可攜式血氧濃度計之裝置示意圖； _第五圖為量測人體脈動所取得之血脈波圖形，主 示週期性振動波之時域分佈； 要揭 第六圖為上述週期性振動波經傅立葉轉換後之頻域八 【主要元件符號說明】 電腦系統(10) 第一發光體(30；) 第一反射光束(302) 第二光束(401) 光感測器(50) 二階高通濾波器(61) 二階低通濾波器(65) 反相放大器(69) 傳輸介面(80) 螢幕游標(91) 生理資訊(94) 生理資訊(98) 滑鼠主體(20) 第一光束(301) 第二發光體(40) 第二反射光束(402) 放大電路(60) 增益放大器(63) 微分器(67) 類比/數位轉換器(70) 處理裝置(90) 生理資訊(92) 生理資訊(96)13 201106920 [Simplified description of the drawings] FIG. 1 is a schematic structural diagram of a first preferred embodiment of the present invention; FIG. 2 is a circuit block diagram of a first preferred embodiment of the present invention; The action flow chart of the preferred embodiment reveals the operation of the processing device; the main fourth picture is a schematic diagram of the device of the conventional portable blood oxygen concentration meter; _the fifth figure shows the blood wave pattern obtained by measuring the pulse of the human body, The time-domain distribution of periodic vibration waves; The sixth figure is the frequency domain of the above-mentioned periodic vibration wave after Fourier transform. [Main component symbol description] Computer system (10) First illuminant (30;) First reflection Beam (302) Second Beam (401) Photosensor (50) Second-Order High-Pass Filter (61) Second-Order Low-Pass Filter (65) Inverting Amplifier (69) Transmission Interface (80) Screen Cursor (91) Physiological Information (94) Physiological Information (98) Mouse Body (20) First Light Beam (301) Second Light Emitter (40) Second Reflected Light Beam (402) Amplifying Circuit (60) Gain Amplifier (63) Differentiator (67) Analogy /digital converter (70) processing device (90) physiological information (92) physiological information (96)