201041610 四、指定代表圖： (一) 本案指定代表圖為：無201041610 IV. Designated representative map: (1) The representative representative of the case is: No
(二) 本代表圖之元件符號簡單說明：I 五案若有化學式時，請揭示最能顯示發鴨徵的化學式 六、發明說明： 【發明所屬之技術領域】(2) A brief description of the symbol of the representative figure: If there is a chemical formula in the case of I, please disclose the chemical formula that best shows the sign of the duck. VI. Description of the invention: [Technical field of invention]
本發明屬於醫療器具之洗淨、賴、除臭處理方法 術領域，制是-種制二氧化氣在#療器具之 用相關技 菌、除臭處理方法之應用 【先前技術】 二氧化氯(C1G2)是-種帶有辛魏味的黃、綠色氣體，具有高效的 消毒力’而且符合使關安全性，為世界衛生域和世界糧農纽織向 全世界所推薦’是目前國際上公認的新-代廣效強力殺菌劑、高效氧 化劑和優良漂白劑’獲世界各國所廣泛採用。The invention belongs to the field of washing, smear and deodorizing treatment methods for medical instruments, and is applicable to the application of related technologies and deodorizing treatment methods for the production of oxidizing gas in the therapeutic apparatus. [Prior Art] Chlorine dioxide ( C1G2) is a kind of yellow and green gas with Xin Weiwei, which has high disinfection force 'and is in line with the safety of customs, and is recommended to the world for the world health sector and the world's food and agriculture knuckles' is internationally recognized. New-generation broad-spectrum powerful fungicides, high-efficiency oxidants and excellent bleaches have been widely adopted in countries all over the world.
二氧化氣(C102)在常溫下水中的溶解度為2. 9g/l，氧化力為漂白 水的2. 6倍，且有很寬PH值範圍殺菌效果【丨】，可在低濃度、適當 的接觸時間下對細菌及病毒進行消毒【2】，且與次氯酸納具有相同可 去除管道中生物膜’不產生抗藥性’避免細菌滋生的特性及具有過醋 酸的氧化能力。 在空氣中，二氧化氣(Cl〇2)會分散於空氣中氧化懸浮於空氣中之 有害物質；而在水體中則可以氣體方式溶於水中，直接氧化與溶液操 觸之物質’對感染區之物體表面及空氣同時消毒，可有效嚴堵如 SARS、豬流感等經由空氣飛沬及接觸傳染的病毒擴散。 二氧化氣(Cl〇2)對細胞壁有較強的穿透能力，可有效氧化細胞中含 硫基的醇，可快速地抑制微生物蛋白質的合成來破壞原菌、真菌和病 毒等，因此二氧化氯除對一般細菌外，還對芽胞、病毒、藻類、異菌， 2 201041610 在氡化的同時，不會伴 鐵細菌、及硫酸鹽等均具有很好的殺滅作用 隨氯化作用而產生氯仿等有機致癌物。 二氧化氣(C1G2)目前廣泛用於食品加卫、醫療衛生、飲用水、環 境、工程搞等之料、殺菌及除缝理，騎 消毒劑’而且美國環境保護署⑽）亦批_於醫療衛生業儀器設 備的消毒。The solubility of the oxidizing gas (C102) in the water at room temperature is 2. 9g / l, the oxidizing power is 2.6 times the bleaching water, and has a wide range of PH value sterilization effect [丨], can be in low concentration, appropriate Bacterial and virus disinfection under contact time [2], and with the same sodium hypochlorite can remove the biofilm in the pipeline 'does not produce resistance' to avoid bacterial growth and has the ability to oxidize peracetic acid. In the air, the dioxide gas (Cl〇2) will be dispersed in the air to oxidize the harmful substances suspended in the air; in the water body, it can be dissolved in the water by gas, directly oxidizing the substance in contact with the solution' Simultaneous disinfection of the surface of the object and the air can effectively block the spread of viruses such as SARS and swine flu via airborne sputum and contact infection. Dioxin (Cl〇2) has strong penetrating ability to the cell wall, can effectively oxidize the sulfur-containing alcohol in cells, and can quickly inhibit the synthesis of microbial proteins to destroy the original bacteria, fungi and viruses, etc. In addition to the general bacteria, chlorine also has spores, viruses, algae, and other bacteria. 2 201041610 At the same time, it does not have a good killing effect with iron bacteria and sulfates. Organic carcinogens such as chloroform. Dioxide gas (C1G2) is currently widely used in food hygiene, medical and health, drinking water, environment, engineering, etc., sterilization and de-stitching, riding disinfectant 'and the US Environmental Protection Agency (10)) also approved _ in medical Disinfection of sanitary equipment.
一般醫療器材治療結束後，赫是必須執行的重要步驟4统上 多使用漂白水(次氣_)或過醋酸為消毒液，雖然消毒效果良好，但 漂白水為強鹼性的溶液，在PH值大於9的環境下，所能產生具有殺 菌力的「次氣酸」不到5%’因此需使用較高濃度才能達到殺菌的效果， 導致消毒後所需沖洗的_增長·’糾高濃度的鮮水在水體易與腐 植酸作用產生致癌的三氣甲烷，造成環境的危害；而過醋酸具有很強 剌鼻味及對皮膚的腐蝕性，長期暴露下易造成人體健康方面的危害。 如何解決先前技術中所列在漂白水PH值大於9的環境下殺菌力 低，與過醋酸的強剌鼻味及腐蝕性和對人體健康的危害性之問題，一 直是市場上的需求。二氧化氯易溶於水，功效十分穩定，殺菌效果不 受水體的pH度(pH= 6 ~ 10範圍内）與氨氮的影響。【3】，但是市場上 的實際使用操作尚未十分明確。 參考文獻 【1】梁增輝’揚宗芬，王福玉等：PH值對穩定性二氧化氣消毒劑活化 影響的研究，中國消毒學雜誌1990 ; 7(1) : 1-5 【2】劉明哲’賴國政··環境消毒劑-二氧化氯藥效試驗探討，環境檢 驗 2003. 8 ; 48 : 16~23 【3】Protech Environmental Control Co. LTD , 2005 【發明内容】 3 201041610 本發明的目的在於提供一種新型醫療儀器之消毒方法。 . 本發麵使肖之新鶴賴胃之消毒綠包括使帛二氧化氯水溶 液或使用二氧化氯氣體’步驟更包括將醫療器具經清水預先洗淨、浸 潰於二氧減水溶液如二氧化氯水溶騎通上述管路巾空部以及 後處理以清水洗淨並施加乾燥處理。且其中二氧化氯水溶液濃度介於 1000ppm~5000ppm間。其中二氧化氣水溶液之較佳濃度範圍介於 4000ppm〜5000ppm間，其中接觸二氧化氣氣體之時間範圍介於3_5分 鐘。 〇 因本發明所使用之二氧化氣相較於過醋酸及漂白水的優點包括 高效率、快速的殺菌效果，二氧化氣藥效持久，約為氣的10倍。且 二氧化氣不會和水體中的有機物反應生成致癌有毒的氣代副物，如三 氣甲烧和ii乙酸。對水中的色素、臭味 '異味和鐵 '猛具有較好的去 除效果。在水中的溶解度是氯氣的5倍，適於水體消毒並能維持更長 的抑菌時間，可防止管線中的細菌再度繁殖。安全、無味、無毒、 穩定性強、對人畜無害；可安全地使用。能有效地破壞酚、氣酚、 硫醇等有機毒物反應；能快速徹底殺滅和抑制藻類， 〇 因本發明之較佳實施例，證明使用本發明之方法與現有技術相比， 由於改變了使用傳統漂白水與過醋酸做為消毒液，而提供一種殺菌能 力高，並可以較短時間、較少用量、操作方便、且安全可靠的方式除 去附箸於上述醫療儀器插入體内外部管線以及上述管線中空部之血 液、黏液，微小組織碎片等有形附著物之二氧化氣在醫療儀器管線之 消毒應用》 【實施方式】 本發明之實施例’分別以5000ppm、4000ppm、2500ppm二氧化 氯作消毒劑，並以鹽酸作為活化劑，以不同消毒液比較操作時間、浸 泡時間、沖洗時間、過醋酸與二氧化氯用量比較、漂白水與二氧化氯 4 201041610 用量比較。 實施例一：不同消毒劑的比較 以下就二氧化氣水溶液，洗淨、滅菌受污染之醫療儀器’測試其 殺菌、消毒能力效果，並將實驗結果列於下。 二氧化氣消毒劑5000ppm、4000ppm、2500ppm (購買自川漱生化科 技）、次氣酸納漂白水60000ppm、過醋酸40000ppm。 (1)分別以不同之消毒液，不同之消毒時間進行消毒，實驗結果列於 〇 第一表^ 第一表.不同消毒液殺菌能力比較 消毒液種類 前水洗時間 (min) 吸消毒液 時間 (min) 浸泡時間 (min) 沖洗時 間 (min) 總生菌數 (CFU/mL) RO水 3 10 0 30 >200 4% Peracetic Acid 3 12 10 30 5 6% Sodium Hypoclorite 3 15 5 30 6 5000ppm(C102) 3 10 0 30 Non-Growth 4000ppm(C102) 3 5 0 30 Non-Growth 2500ppm(C102) 3 12 5 30 18 利用5000ppm二氧化氣水溶液吸取10分鐘沖洗30分鐘及4000ppm二 氧化氣水溶液吸取5分鐘沖洗30分鐘可穩定的達到殺菌之效果。全部 使用時間約為43分鐘，相較於漂白水消毒需費時53分鐘，過醋酸需 費時55分鐘，平均可節省10-12分鐘，可達成節省時間之效益。 實施例二：較佳濃度的選擇資驗 以下就二氧化氯水溶液，洗淨、滅菌受污染之醫療儀器，測試其殺 菌、消毒之有效殺菌濃度，並將實驗結果列於下。 (1)分別以不同濃度之二氧化氣消毒液，在不同之消毒時間進行測試， 結果如第二表。 5 201041610 第二表.不同濃度Cl〇2殺菌效果比較 消毒液種類 前水洗 時間 (min) 吸消毒液 時間 (min) 浸泡時間 (min) 沖洗時間 (min) 總生菌數 (CFU/ml) 5000ppm(Cl〇2) 3 10 0 30 Non-growth 4000ppm(Cl〇2) 3 5 0 30 Non-growth 2500ppm(CI〇2) 3 12 5 30 18 2500ppm(Cl〇2) 3 12 5 30 109 2500ppm(Cl〇2) 3 12 5 30 11 2500ppm(Cl〇2) 3 12 5 30 5 2500ppm(Cl〇2) 3 10 0 30 >200 2500ppm(C10〇 3 5 12 30 5 2500ppm(Cl〇2) 3 5 12 30 1 可以發現以二氧化氣消毒液吸取時間12分鐘靜置5分鐘與吸取5分鐘 靜置12分鐘，兩者都具有相近的消毒效果。 實施例三：殘留率的實驗 以下就二氧化氣水溶液，洗淨、滅菌受污染之醫療儀器，測試其殺 菌、消毒之消毒液殘留濃度，並將實驗結果列於下。 (1)以5000ppm二氧化氣水溶液吸取10分鐘隨後沖洗30分鐘，其間測試 管路沖洗過程中消毒液氧化物、總氣、二氧化氯殘餘濃度測試，結果於 第三表。 __第三表.5Q00ppm C102沖洗殘餘物檢測 沖洗時間(min) Residual Peroxide (ppm) Total Chlorine(ppm) C102(ppm) 0 >10 >10 100-250 <10 10 <5 <1 ' 15 <3 <0.5 <1 20 <1 <0.1 1 <0.5 25 <1 <0.1 __ <0.25 <0.25 30 <1 <0.1 — 證實二氧化氣水溶液在持續的沖洗下，可由初約2〇〇ppm漢度在 沖洗30分鐘後迅速的降低到接近〇. 25ppm以下，而過氧化物及總氣 201041610 皆無法測出的情形，在總生菌數方面可以達到完全不長菌的效果。 實施例四••本發明舆舆過醋酸以不同使用量舆使用時間比較 以下就二氧化氯水溶液’洗淨、滅菌受污染之醫療儀器，測試其殺 菌、消毒之消毒液殘留濃度，並將實驗結果列於下。 第四表。 (1)以2500ppm二氧化氯水溶液測試過醋酸與二氧化氣用量比較，結果於 比較項目 過醏酸 二氧化氯 每天使用1次 (無肝炎使用） 每天使用3次 (有肝炎使用） 每天使用1次 (無肝炎使用） 每天使用3次 (有肝炎使用） 吸取時間/吸取量 12 分鐘 / 300cc — 5 分饞 / 120cc 產品規格/可使用 次數 3· 78公升/ 13次 2公升/ 15次 每週使用次數 3次 9次 3次 9次 每瓶可使用時間 約4遇 4個工作日 5遘 5個工作日 每月（5遇)使用量 1.15 瓶 3.75 瓶 1瓶 3瓶 每月（5通）總使用量 預枯 75 台 xl. 15 瓶+25 台 x3. 75 瓶=180 瓶 75台xl瓶+25台x3瓶=150瓶 以二氧化氣取代過醋酸’每月（以5週計算）需使用15〇瓶二氧化氣(2公 升2500ppm) ’而目前過醋酸每月（以4週計算)使用量約為180瓶。相較 之下，二氡化氣在每次吸取量、每日用量推算到每月用量都比過醋酸來 得划算，在消毒效果上經測試後也完全符合消求。 實施例五：本發明舆舆漂白水以不同使用董舆使用時間比較 以下就二氧化氣水溶液，洗淨、滅菌受污染之醫療儀器’測試其殺 菌、消毒之消毒液殘留濃度，並將實驗結果列於下。 (1)以2500ppm二氧化氣水溶液測試漂白水與二氧化氣用量比較，結果於 第五表。 """ ----- —_ " ~ ~ 比較項目 漂白水 二氧化氣 7 201041610 吸取時間/吸取量— 產品規格/ 次數 每天使用1次 <(無肝炎使用） 一 15分鐘」 每天使用3次 (有肝炎使用） f 360cc 莓天使用1次 (無肝炎使用） 5分鐘/ 1 每天使用3次 (有肝炎使用） 20cc 4公升/ 11次 2公升/ 15次 每週使用次數 3次 9次 3次 9次 每瓶可使用時間 每月（5週)使用量 _不到4遇 4個工作日 5遇 5個工作曰 1.36 瓶 4.1瓶 1瓶 3概 每月（5遇）總使用量 預枯 75 台 xl. 36 瓶+25 台 χ4.1 瓶=205 瓶 75台xl瓶+25台χ3 瓶=150 以二氧化氯取代漂白水’每月（以5週計算）需使150瓶二氧化氣(2公升 2500ppm)，而目前漂白水每月（以4週計算)使用量約為205瓶。相較之下， 二氧化氯在每次吸取量、每日用量推算到每月用量都比漂白水來得少， 在消毒效果上經測試後也完全符合需求。 雖然本發明已以較佳實施例揭露如上，然其並非用以限定本發 明’任何熟習此技藝者，在不脫離本發明之精神和範圍内，當可作 些許之更動與潤飾，因此本發明之保護範圍當視後附之申請專利範 圍所界定者為準。 【圖式簡單說明】 無 【主要元件符號說明】 無 8After the treatment of general medical equipment, He is an important step that must be carried out. 4 Use bleach (sub-gas _) or peracetic acid as disinfectant. Although the disinfection effect is good, the bleach is a strongly alkaline solution at PH. In an environment with a value greater than 9, the "sub-gas acid" with bactericidal power can be produced less than 5%. Therefore, it is necessary to use a higher concentration to achieve the sterilization effect, resulting in the _growth of the rinse required after disinfection. The fresh water is easy to react with humic acid in the water to produce carcinogenic tri-methane, which causes environmental hazards. Peracetic acid has a strong nasal odor and corrosive to the skin, which may cause harm to human health under long-term exposure. How to solve the problems listed in the prior art that the bactericidal power is low in the environment where the pH value of the bleaching water is greater than 9, and the strong nasal odor and corrosiveness of the peracetic acid and the health hazard to human health have been the market demand. Chlorine dioxide is easily soluble in water and its effect is very stable. The bactericidal effect is not affected by the pH of the water (pH = 6 ~ 10) and ammonia nitrogen. [3], but the actual operation in the market is not yet clear. References [1] Liang Zenghui' Yang Zongfen, Wang Fuyu et al: Study on the effect of pH on the activation of stable dioxide gas disinfectant, Chinese Journal of Disinfection 1990; 7(1): 1-5 [2] Liu Mingzhe' Lai Guozheng·Environmental disinfectant-chlorine dioxide efficacy test, environmental inspection 2003. 8; 48: 16~23 [3] Protech Environmental Control Co. LTD, 2005 [Summary] 3 201041610 The object of the present invention is to provide A new method of disinfecting medical instruments. The method of making the disinfection green of Xiaoxinhe Laiwei including the aqueous solution of chlorine dioxide or using chlorine dioxide gas further includes pre-washing and immersing the medical device in a dioxic aqueous solution such as chlorine dioxide. The water-soluble ride is passed through the above-mentioned pipe towel empty portion and post-treatment, washed with water and subjected to drying treatment. And wherein the concentration of the chlorine dioxide aqueous solution is between 1000 ppm and 5000 ppm. The preferred concentration range of the aqueous solution of the dilute gas is between 4000 ppm and 5000 ppm, and the time range for contacting the gas of the dioxide gas is between 3 and 5 minutes. 〇 The advantages of the oxidizing gas phase used in the present invention over peracetic acid and bleaching water include high efficiency and rapid bactericidal effect, and the oxidizing gas has a long lasting effect, which is about 10 times that of the gas. And the dioxide gas does not react with the organic matter in the water to form carcinogenic and toxic gas by-products, such as trimethyl and ii acetic acid. It has a good removal effect on the pigments and odors of the water, odor and iron. The solubility in water is 5 times that of chlorine, which is suitable for water disinfection and can maintain a longer antibacterial time, preventing bacteria in the pipeline from re-breeding. Safe, odorless, non-toxic, stable, harmless to humans and animals; safe to use. It can effectively destroy the reaction of organic poisons such as phenol, phenol, thiol, etc.; it can quickly and completely kill and inhibit algae. As a result of the preferred embodiment of the present invention, it proves that the method of the present invention is changed compared with the prior art. Using traditional bleaching water and peracetic acid as a disinfectant, it provides a high sterilizing ability, and can be removed in a short time, in a small amount, in a convenient operation, and in a safe and reliable manner. The disinfection application of the oxidized gas of the visible deposits such as blood, mucus, and microscopic tissue fragments in the hollow portion of the pipeline in the medical instrument pipeline" Embodiments of the present invention are sterilized by using 5000 ppm, 4000 ppm, and 2500 ppm of chlorine dioxide, respectively. And use hydrochloric acid as activator, compare the operation time, soaking time, rinsing time, the ratio of peracetic acid to chlorine dioxide, and the amount of bleach and chlorine dioxide 4 201041610. Example 1: Comparison of different disinfectants The following is a description of the sterilization and disinfection ability of a medical device that cleans and sterilizes contaminated medical equipment, and the experimental results are listed below. Dioxide gas disinfectant 5000ppm, 4000ppm, 2500ppm (purchased from Chuanxiong Biochemical Technology), sub-gas soda bleach 60000ppm, peracetic acid 40,000ppm. (1) Disinfect with different disinfectant and different disinfection time respectively. The experimental results are listed in the first table of the first table. The first table. The disinfection ability of different disinfectants is compared with the type of disinfectant before the washing time (min). Min) Soaking time (min) Washing time (min) Total bacterial count (CFU/mL) RO water 3 10 0 30 > 200 4% Peracetic Acid 3 12 10 30 5 6% Sodium Hypoclorite 3 15 5 30 6 5000 ppm ( C102) 3 10 0 30 Non-Growth 4000ppm (C102) 3 5 0 30 Non-Growth 2500ppm (C102) 3 12 5 30 18 Flush for 10 minutes with 5000ppm aqueous solution of dioxane for 30 minutes and 4000ppm aqueous solution of dioxane for 5 minutes. Rinse for 30 minutes to achieve a stable sterilization effect. The total use time is about 43 minutes, which takes 53 minutes compared to bleach disinfection, and 55 minutes for peracetic acid, which saves an average of 10-12 minutes, saving time. Example 2: Selection of Preferred Concentrations The following measures are used to clean and sterilize contaminated medical instruments with chlorine dioxide aqueous solution, and to test the effective bactericidal concentration of bactericidal and disinfecting, and the experimental results are listed below. (1) Test with different concentrations of dioxide gas disinfectant at different disinfection times, the results are shown in the second table. 5 201041610 The second table. Different concentrations of Cl〇2 sterilization effect comparison disinfectant type before washing time (min) suction disinfection time (min) soaking time (min) washing time (min) total bacteria number (CFU / ml) 5000ppm (Cl〇2) 3 10 0 30 Non-growth 4000 ppm (Cl〇2) 3 5 0 30 Non-growth 2500 ppm (CI〇2) 3 12 5 30 18 2500 ppm (Cl〇2) 3 12 5 30 109 2500 ppm (Cl 〇 2) 3 12 5 30 11 2500 ppm (Cl 〇 2) 3 12 5 30 5 2500 ppm (Cl 〇 2) 3 10 0 30 > 200 2500 ppm (C10 〇 3 5 12 30 5 2500 ppm (Cl 〇 2) 3 5 12 30 1 It can be found that the absorption time of the sulfur dioxide disinfectant is allowed to stand for 5 minutes for 12 minutes and the suction for 5 minutes for 12 minutes, both of which have similar disinfection effects. Example 3: Experiment of residual rate The following is an aqueous solution of sulfur dioxide Wash and sterilize the contaminated medical equipment, test the residual concentration of the disinfectant and disinfection solution, and list the experimental results. (1) Absorb with 5000ppm dioxane aqueous solution for 10 minutes and then rinse for 30 minutes, during which the test tube The residual concentration of disinfectant oxide, total gas and chlorine dioxide during the road washing process is tested in the third table. __ Three Tables. 5Q00ppm C102 Flush Residue Detection Flush Time (min) Residual Peroxide (ppm) Total Chlorine (ppm) C102 (ppm) 0 >10 >10 100-250 <10 10 <5 <1 ' 15 <3 <0.5 <1 20 <1 <0.1 1 <0.5 25 <1 <0.1 __ <0.25 <0.25 30 <1 < 0.1 - Confirmation that the aqueous solution of hydrogen dioxide is continuous Under the rinsing, it can be quickly reduced to about 〇.25ppm after rinsing for 30 minutes, and the peroxide and total gas 201041610 can not be measured, and the total number of bacteria can be reached. The effect of the bacteria is not at all. Example 4•• The present invention is used for the treatment of sterilizing and disinfecting the medical equipment of the chlorine dioxide aqueous solution by washing and sterilizing the contaminated medical equipment. The residual concentration of the liquid, and the experimental results are listed below. The fourth table. (1) The comparison of the amount of acetic acid and dioxide dioxide in a 2,500 ppm chlorine dioxide aqueous solution was carried out. The results were compared with the perchloric acid chlorine dioxide used once per day (no hepatitis). 3 times a day (with hepatitis) 1 used per day Times (without hepatitis) 3 times a day (with hepatitis) Absorption time / Absorption amount 12 minutes / 300cc - 5 minutes / 120cc Product specifications / Available times 3 · 78 liters / 13 times 2 liters / 15 times per week Use 3 times 9 times 3 times 9 times Each bottle can be used for about 4 working days 5 5 working days per month (5 cases) Usage 1.15 Bottles 3.75 Bottles 1 bottle 3 bottles per month (5 passes) Total usage pre-dry 75 sets xl. 15 bottles +25 sets x3. 75 bottles = 180 bottles 75 sets xl bottles +25 sets x3 bottles = 150 bottles replaced with acetic acid by peroxy acetic acid 'monthly (calculated in 5 weeks) Use 15 bottles of dioxide gas (2 liters 2500 ppm)' and currently peracetic acid (about 4 weeks) is about 180 bottles. In contrast, the amount of dioxiqi in each intake and daily dosage is calculated to be more cost-effective than peracetic acid. After the test, the disinfection effect is completely consistent with the elimination. Embodiment 5: In the present invention, the use time of the bleaching water is different. The following is the use of the aqueous solution of the dioxin, washing and sterilizing the contaminated medical instrument to test the residual concentration of the disinfecting solution for sterilization and disinfection, and the experimental result Listed below. (1) The amount of bleach water and the amount of dioxide gas was measured by using a 2,500 ppm aqueous solution of hydrogen dioxide, and the results are shown in the fifth table. """ -----__ " ~ ~ Comparison Project Bleach Water Dioxide 7 201041610 Absorption Time / Absorption - Product Specifications / Times 1 time per day <(No hepatitis use) 15 minutes Use 3 times a day (with hepatitis) f 360cc Raspberry Day 1 time (no hepatitis) 5 minutes / 1 3 times a day (with hepatitis) 20cc 4 liters / 11 times 2 liters / 15 times per week 3 times 9 times 3 times 9 times each bottle can be used monthly (5 weeks) usage _ less than 4 cases 4 working days 5 encounters 5 work 曰 1.36 bottles 4.1 bottles 1 bottle 3 monthly (5 cases) Total usage pre-dry 75 sets xl. 36 bottles +25 sets χ 4.1 bottles = 205 bottles 75 x l bottles + 25 sets χ 3 bottles = 150 replace bleach with chlorine dioxide 'monthly (in 5 weeks) need to make 150 bottles of dioxide (2 liters 2500 ppm), while current bleach (about 4 weeks) is about 205 bottles. In contrast, chlorine dioxide is estimated to be less than the amount of bleach per use per aspiration and daily dosage, and it is fully in compliance with the requirements after the disinfection effect has been tested. While the present invention has been described in its preferred embodiments, the present invention is not intended to limit the invention, and the invention may be modified and modified without departing from the spirit and scope of the invention. The scope of protection is subject to the definition of the scope of the patent application. [Simple description of the diagram] None [Key component symbol description] None 8