201018494 六、發明說明： 【發明所屬之技術領域】 本發明係關於一種濃縮洗髮精組合物。 【先前技術】 雖然先前技術如此，仍需要改良的濃縮洗髮精組合物。 【發明内容】 據此，本發明提供一種濃縮洗髮精組合物，其含有25至 70重量％之鹼金屬烷基醚硫酸鹽及具有〇.〇5至0.4胺基數之 ® 胺基聚矽氧。 【實施方式】 胺基聚矽氧會改善流變性及產品相，以致當稀釋產品 時，不會出現六角形液晶相。產品中六角形相使其在使用 時難以清洗及溶解於水中。 合適的胺基聚石夕氧包括彼等購自Wacker之HL29(其具有 0.3胺基數）或8[]^2901(其具有0.12胺基數）。胺基二甲矽酮 (amodimethicone)乳液亦合適，例如DC-8177 及 DC-939(來 自 Dow Corning)及 SME253(來自 GE Silicones)。必需有最 佳胺基數，以便在本發明所指定之高濃度下保持該產品之 -顏色安定。 . 較佳地，該胺基聚矽氧之平均粒度（D50)為1至100微 米，更佳為10至50,及最佳為15至25微米，其藉由衍射法 激光粒度儀（Malvern Mastersizer)測量。 較佳地，該胺基聚矽氧以占組合物之0.01%至2重量％存 在，更佳以0.1至1.8%，且最佳以占組合物之0.2至1.4重量 143422.doc 201018494 %存在。 較佳地，該濃縮洗髮精組合物包括多元醇。更佳為具有 n=3至n=l〇〇，及更佳n=4至n=20之聚合度的聚丙二醇。當 暴露於空氣中時或在其配送後但在使用者即將稀釋使用之 刖，丙二醇有助於控制產品黏性，亦可阻止濃縮洗髮精組 合物提早變乾。 較佳地，聚丙二醇以占組合物之〇」至3重量％存在更 佳0.2至2.0及最佳以占組合物之〇 4至15重量％存在。 較佳地，該濃縮洗髮精組合物包含以〇 2%至〇 4%(更佳 〇.5〇/。至2.5%)存在之電解質。電解質有助於建立該洗髮精 產品之黏性。因為高濃縮，所以稠度有助於控制產品以遠 低於所需量配送。較佳電解質包括卸及納之氣化物。最佳 電解質為氣化鈉。 本發明組合物包含一或多種陰離子清潔表面活性劑，^ 係美容上可接受且適合局部施用於頭髮。 較佳的烷基基團含有8至18 ’更佳1〇至16個碳原子及〒 係不飽和冑然該等為飽和時較佳。每分子之烧基崎硫画 鹽含有1至2G個環氧乙燒單元，較佳為⑴個，及最佳為 個環氧乙烷單元。 最佳陰離子清潔表面活性劑為月桂基喊硫酸納⑻EO’ (其中η為1至3)。 本發明組合物中，陰離子清潔表面活性劑之總量一般』 占該組合物總重量之2〇 5 m〇/ x,. 20至70/g，較佳27至60%，更佳為3 至56 %之陰離子清潔表面活性劑總重量。 143422.doc 201018494 視需要，本發明組合物進一步含有下文所述之成分，以 增強效能及/或消費者可接受度。 輔助表面活性劑 5亥組合物包括辅助表面活性劑，以有助於給予該組合物 美學上、物理上或清潔上的性質。 輔助表面活性劑之實例為非離子表面活性劑，其含量占 該組合物總重量之〇.5至2〇%，較佳〇7至6重量％之範圍 内。 φ 例如，可包含在本發明之洗髮精組合物中之代表性非離 子表面活性劑包括脂肪族（C8_Ci8) 一級或二級直鏈或分支 鏈酵或酚類與氧化烯烴（通常為環氧乙烷）之縮合物，且通 常具有6至30個環氧乙院基團。 其它代表性非離子表面活性劑包括單_或二烷基烷醇醯 胺。實例包括椰油基單·或二乙醇醯胺及椰油基單_異丙醇 醯胺。尤佳非離子表面活性劑為椰油基單乙醇醯胺。 〇 可包含在本發明洗髮精組合物中之其它非離子表面活性 劑為烷基聚糖苷（APG)。一般地，APG係包含接合（視需要 經由橋聯基團）至一或多個糖基嵌段之烷基之物質。較佳 的APG係如下通式之定義： R〇-(G)n 其中R為分支鏈或直鏈烷基，其可係飽和或不飽和及〇 為聽基。 R可表示約C5至約C20之平均烷基鏈長度。較佳的尺表示 約a至約Cu之平均烷基鏈長度。最佳R值位於約9 5與約 143422.doc 201018494 1〇.5間。G可選自Cs或C6單醣殘基’且較佳為糖苷。G可選 含有以下物質之群：葡萄糖、木糖、乳糖、果糖、甘露 糖及其衍生物。較佳G為葡萄糖。 聚合度，η，具有約1至約1〇或更高之值。較佳地，11值 位於約1.1至約2。最佳η值位於約1.3至約1.5。 用於本發明之合適燒基聚糖普係自商品取得且包括例 如’㈣如下之該等物質如：來自s即pic之〇ramix職〇、201018494 6. INSTRUCTIONS OF THE INVENTION: TECHNICAL FIELD OF THE INVENTION The present invention relates to a concentrated shampoo composition. [Prior Art] Although the prior art is such, there is still a need for an improved concentrated shampoo composition. SUMMARY OF THE INVENTION Accordingly, the present invention provides a concentrated shampoo composition containing 25 to 70% by weight of an alkali metal alkyl ether sulfate and having an amine group of 5 to 0.4 amine groups. . [Embodiment] Amine-based polyoxane improves rheology and product phase so that a hexagonal liquid crystal phase does not occur when the product is diluted. The hexagonal phase of the product makes it difficult to clean and dissolve in water during use. Suitable amine polyoxime oxygens include those available from Wacker as HL29 (which has a 0.3 amine number) or 8 []^2901 (which has a 0.12 amine number). Also suitable are amodimethicone emulsions such as DC-8177 and DC-939 (from Dow Corning) and SME253 (from GE Silicones). It is necessary to have the optimum number of amine groups in order to maintain the color stability of the product at the high concentrations specified in the present invention. Preferably, the amine polyfluorene oxide has an average particle size (D50) of from 1 to 100 μm, more preferably from 10 to 50, and most preferably from 15 to 25 μm, by a diffraction laser particle size analyzer (Malvern Mastersizer) )measuring. Preferably, the amine polyoxyl is present in an amount of from 0.01% to 2% by weight of the composition, more preferably from 0.1 to 1.8%, and most preferably from 0.2 to 1.4 by weight of the composition 143422.doc 201018494%. Preferably, the concentrated shampoo composition comprises a polyol. More preferably, it is a polypropylene glycol having a polymerization degree of n = 3 to n = 1 Å, and more preferably n = 4 to n = 20. When exposed to air or after delivery but after the user is about to dilute it, propylene glycol helps control the viscosity of the product and prevents the concentrated shampoo composition from drying out early. Preferably, the polypropylene glycol is present in an amount of from 0.2 to 2.0% by weight of the composition to 3% by weight and most preferably from 4 to 15% by weight of the composition. Preferably, the concentrated shampoo composition comprises an electrolyte in an amount of from 2% to 4% (more preferably 0.5% to 2.5%). The electrolyte helps to establish the viscosity of the shampoo product. Because of its high concentration, consistency helps control the product to be delivered far below the required amount. Preferred electrolytes include unloaded and vaporized gas. The best electrolyte is sodium vaporized. The compositions of the present invention comprise one or more anionic cleansing surfactants which are cosmetically acceptable and suitable for topical application to the hair. Preferred alkyl groups contain from 8 to 18' more preferably from 1 to 16 carbon atoms and are preferably unsaturated when saturated. The salt of the sulphonic salt of each molecule contains 1 to 2G epoxy bromide units, preferably (1), and most preferably an ethylene oxide unit. The most preferred anionic cleansing surfactant is sodium lauryl sulfate (8) EO' (where n is 1 to 3). In the composition of the present invention, the total amount of the anionic cleansing surfactant is generally from 2 to 5 m 〇 / x, from 20 to 70 / g, preferably from 27 to 60%, more preferably from 3 to the total weight of the composition. 56% of the total weight of the anionic cleansing surfactant. 143422.doc 201018494 Optionally, the compositions of the present invention further comprise the ingredients described below to enhance potency and/or consumer acceptability. Co-surfactant The 5H composition includes a co-surfactant to aid in imparting aesthetic, physical or cleansing properties to the composition. An example of a co-surfactant is a nonionic surfactant in an amount of from 55 to 2% by weight, preferably from 〇7 to 6% by weight, based on the total weight of the composition. φ For example, representative nonionic surfactants which may be included in the shampoo compositions of the present invention include aliphatic (C8_Ci8) primary or secondary linear or branched chain leaven or phenols and alkylene oxides (usually epoxy). A condensate of ethane) and usually has from 6 to 30 epoxy groups. Other representative nonionic surfactants include mono- or dialkyl alkanolamines. Examples include cocoyl mono- or diethanolamine and coco mono-isopropanol decylamine. A preferred nonionic surfactant is coco monoethanolamine. Further, other nonionic surfactants which may be included in the shampoo compositions of the present invention are alkyl polyglycosides (APGs). Generally, the APG comprises a material that joins (optionally via a bridging group) to an alkyl group of one or more glycosyl blocks. Preferred APGs are as defined by the formula: R〇-(G)n wherein R is a branched or straight chain alkyl group which may be saturated or unsaturated and oxime is an auditory group. R may represent an average alkyl chain length of from about C5 to about C20. Preferred scales represent the average alkyl chain length from about a to about Cu. The optimal R value is between about 9 5 and about 143422.doc 201018494 1〇.5. G may be selected from a Cs or C6 monosaccharide residue' and is preferably a glycoside. G can be selected from the group consisting of glucose, xylose, lactose, fructose, mannose and its derivatives. Preferably G is glucose. The degree of polymerization, η, has a value of from about 1 to about 1 Torr or higher. Preferably, the value of 11 is between about 1.1 and about 2. The optimum η value is between about 1.3 and about 1.5. Suitable sinter glycans for use in the present invention are obtained from commercial sources and include, for example, the following substances such as: 〇 ramix jobs from s, pic
Plantaren 1200及來自 Henkel：^plantaren 2〇⑽。 可包括在本發明組合物中之其它糖衍生的非離子表面活 性劑包括Cl(rCl8 N-烷基（C〗-C6)多羥基脂肪酸醯胺，例如 c12-c18n-甲基葡醯胺，其描述於例如w〇 92 〇6154及us 5 194 639中，及N-烷氧基多羥基脂肪酸醯胺，例如c10_Cl8 N-(3-甲氧基丙基）葡醯胺。 輔助表面活性劑之較佳實例為兩性或兩性離子表面活性 劑其3量占*亥組合物總重量之〇 · 5至約1 〇重量％，較佳1 至6重量〇/〇。 兩性或兩性離子表面活性劑之實例包括烷基胺氧化物、 烷基甜菜鹼、烷基醯胺丙基甜菜鹼、烷基磺基甜菜鹼 (sultaine)、烷基甘胺酸鹽、烷基羧基甘胺酸鹽、烷基兩性 乙酸鹽、烷基兩性丙酸鹽、烷基兩性甘胺酸鹽、烷基醯胺 丙基羥基磺基甜菜鹼、醯基牛磺酸鹽及醯基麩胺酸鹽，其 中烷基及醯基基團具有8至19個碳原子。用於本發明洗髮 精中之典型兩性及兩性離子表面活性劑包括月桂基胺氧化 物、椰油二甲基磺基丙基甜菜鹼、月桂基甜菜鹼椰油醯 143422.doc 201018494 胺丙基甜菜鹼及椰油兩性乙酸鈉。 尤佳之兩性或兩性離子表面活性劑為椰油醯胺丙基甜菜 驗。 上述任何兩性或兩性離子表面活性劑之混合物亦合適。 ' 較佳混合物為彼等由椰油醢胺丙基甜菜鹼與上述其他兩性 - 或兩性離子表面活性劑形成之混合物。其它較佳的兩性或 兩性離子表面活性劑為椰油兩性乙酸鈉。 Φ 較佳地，本發明頭髮護理組合物係水性，亦即其中含有 水或水溶液或易溶液晶相（lyotropic liquid crystalHne)作為 其主要組份。 適當地，該組合物包含占該組合物總重量1〇至98%的 水’較佳為20至95重量％。 根據本發明組合物可包含其他聚矽氧。 特別佳之聚矽氧調理劑為聚矽氧乳液，如：彼等由聚矽 氧形成者，如：聚二有機矽氧烷，特定言之，CTFA名稱 • 為二甲矽酮（dimethicone)之聚二甲基矽氧烷、CTFA名稱為 二甲矽靈（dimethiconol)之具有羥基端基團之聚二甲基矽氧 烷，及尤佳為CTFA名稱為胺基二甲矽酮（am〇dimethic〇ne) 之具胺基官能基聚二甲基矽氧燒。 本發明組合物之乳液液滴典型地具有〇 〇丨至2〇微米（更佳 0.2至10微米）之索特爾（Sauter)平均液滴直徑（〇3 。 測量該索特爾平均液滴直徑（d3 2)之合適方法係使用 如：衍射法激光粒度儀（MalVern Mastersizer)的儀器進行 雷射掃描。 143422.doc 201018494 用於本發明組合物中之合適聚矽氧乳液係購自聚矽氧供 應商，如：Dow Corning及GE Silicones。最好使用該預形 成之聚矽氧乳液，以便容易加工及控制聚矽氧粒度。此等 預形成之聚矽氧乳液典型地另外地包括一種合適的乳化劑 (如：陰離子或非離子乳化劑，或其混合物），且可藉由化 學乳化方法（如：乳化聚合法），或藉由使用高剪切混合機 之機械式乳化法製備。具有小於0.15微米之索特爾平均液 滴直徑（D3.2)之預形成成聚矽氧乳液一般稱為微乳液。 合適的預形成聚矽氧乳液實例包括乳液DC2-1 766、DC-2-1784 、 DC-1785 、 DC-1786 、 DC-1788 及微乳液 DC2-1865 及DC2-1870(該等皆可自Dow Corning得到）及HL999或 UL981(自Wacker得到）。該等皆係二曱矽靈之乳液或/微乳 液。胺基二甲矽酮乳液亦合適，例如DC2-8177及DC939 (自 Dow Corning 構得）及 SME253(自 GE Silicones 購得）。 其中某些已混合有聚矽氧乳液液滴之高分子量表面活性 嵌段共聚物類型之聚矽氧乳液亦合適，其描述於例如WO 03/094874中。在該物質中，聚矽氧乳液液滴較佳由聚二 有機石夕氧烧（如：彼等如上所述之物質）形成。其中一種較 佳表面活性嵌段共聚物形式係如下通式： H0(CH2CH20)x(CH(CH3)CH20)y(CH2CH20)xH 其中X平均值為4或更大，及y平均值為25或更大。 另一較佳表面嵌段共聚物形式係如下通式： (H0(CH2CH20)a)(CH(CH3)CH20)b)2-N-CH2-CH2-N((OCH2CH(CH3))b(〇CH2CH2)aOH)2 143422.doc 201018494 其中a平均值為2或更大，及b平均值為6或更大。 亦可使用上述任何聚矽氧乳化劑之混合物。 上述聚矽氧乳液於本發明之組合物中之含量通常以占誃 組合物總重量之0.05至15%，較佳〇.5至12 %之聚矽氧總重 量存在* 該聚矽氧較佳以0.5至15重量％，更佳為1至12重量％存 在。 可用於該組合物中之其它組份為短鏈二元醇。 較佳地，該短鏈二元醇具有3至7個碳原子及更佳具有3 或4個碳原子》 更佳地，該短鏈二元醇係選自〗，2_丁二醇、丨，3-丁二 酵、1，4-丁二醇、ι，2·丙：醇、1}3_丙二醇及其混合物。尤 佳地，該短鏈二元醇係選自丨，3_丁二醇及丨，2_丙二醇。 在最佳實施例中，該短鏈二元醇係丨，3_丁二醇。 在較佳實施例中，本發明之組合物包括陽離子沉積聚合 物。 合適的陽離子沉龍助聚合物係均聚物，其係經陽離子 取代或由兩種或多種類型單體形成。該聚合物之重量平均 分子量（Mw)通常在100,000至2〇〇〇〇〇〇道爾頓之間。該聚 合物將具有含陽離子性氮的基團，如：四級銨或質子化胺 基，或其混合物。若該聚合物之分子量域，則調理效果 較差。右太咼，可能有高度拉伸黏度之問題，當倒出時， 導致該組合物產生絲黏性。 含陽離子性氮的基團通常呈取代基，料該陽離子聚合 143422.doc 201018494 物之總單體單元之一部份。因此當聚合物不是均聚物時， 其可含有分隔基非陽離子單體單元。該等聚合物係描述於 CTFA Cosmetic Infredient Directory，第三版中。選擇陽 離子與非陽離子單元之比例，以產生陽離子電荷密度在所 需範圍内之聚合物，其通常為〇.2至3·〇 meq/gm。該聚合物 之陽離子電荷密度宜利用述於美國藥典（us pharmac〇p〇eia) 中，有關用於氮測定之化學試驗法中Kjeldahl方法測定。 合適的陽離子聚合物包括，例如，具有陽離子胺或四級 銨官能基之乙烯基單體與水可溶性分隔基單體（如：（甲基） 丙烯醯胺、烷基及二烷基（甲基）丙浠醯胺、烷基（甲基）丙 烯酸酯、乙烯基己内酯及乙烯基吡咯啶）之共聚物。經烧 基及二燒基取代之單體較佳具有C1_C7烷基，更佳C1_3烷 基。其它合適的分隔基包括乙烯基酯、乙烯基醇、順丁烯 二酸酐、丙二醇及乙二醇。 陽離子胺可為一級、二級或三級胺，其取決於該組合物 之特定種類及pH。一般而言，以二級及三級胺，尤其三級 胺較佳。 經胺取代之乙烯基單體及胺類可依胺形式聚合，然後藉 由季銨化作用轉換為銨。 陽離子聚合物可包括衍生自經胺_及/或四級錢取代之單 體及/或可共存的分隔單體之單體單元的混合物。 合適的陽離子聚合物包括例如： -含陽離子性二烯丙基四級銨的聚合物，其包括例 如’二曱基二稀丙基氣化錄均聚物及丙蝉醯胺與二 143422.doc •10- 201018494 甲基二烯丙基氣化銨之共聚物，在業界（CTFA)中 分別稱為聚季錢鹽（P〇lyquaternium)6及聚季銨鹽 7 ； -具有3至5個碳原子的不飽和羧酸之均聚物及共聚物 之胺基-烧基酯之無機酸鹽（其描述於美國專利案 4,009,256 t )； -陽離子性聚丙烯醯胺（其描述於W095/22311中）。 籲 可使用之其它陽離子聚合物包括陽離子多醣聚合物，例 如陽離子纖維素衍生物、陽離子澱粉衍生物、及陽離子關 華豆膠衍生物。 適用於本發明組合物中之陽離子多醣聚合物包括以下通 式之單體： A-0-[R-N+(R1)(R2)(R3)x-] 其中：A為脫水葡萄糖殘基’如：殿粉或纖維素脫水葡萄 糖殘基。R為伸烷基、氧伸烷基、聚氡伸烷基、或經基伸 φ 烷基、或其組合。R1、R2及R3相互獨立地表示烧基、芳 基、烷芳基、芳烷基、烷氧烷基、或烷氧芳基，各基團含 有至高約1 8個碳原子。每個陽離子部分之碳原子總數 ’ （即，R1、R2及R3中之碳原子總數）較佳為約2〇個或更少， •且X為陰離子性抗衡離子。 另一類陽離子纖維素包括羥乙基纖維素與經月桂酸二甲 基銨取代之環氧化物反應形成的聚合四級錄鹽，在業界 (CFTA)中稱為聚季錄鹽24。該等物質自Amerch〇1 Corporation，例如以 Polymer LM-200商品名得到。 143422.doc 11 201018494 其它合適陽離子多醣聚合物包括含四級氮的纖維素醚 (例如，描述於美國專利案3,962,418中），及醚化纖維素與 澱粉之共聚物（例如，描述於美國專利案3,958,581中）。 特別適合使用之陽離子多醣聚合物類型係陽離子關華豆 膠衍生物，例如關華豆膠羥丙基三甲基氯化銨（以JAGUAR 商品名系列購自Rhodia)。該等物質之實例為JAGUAR C13S、JAGUAR C14、JAGRARC15及 JAGUAR C17。 可使用以上任何一種陽離子聚合物之混合物。 陽離子聚合物一般以占組合物總重量之0.01至5%，較佳 0.05至2%，更佳0.07至1.2%之陽離子聚合物總重量存在於 本發明之洗髮精組合物中。 較佳地，本發明之水性洗髮精組合物可進一步包括懸浮 劑。合適懸浮劑係選自聚丙烯酸、丙烯酸之交聯聚合物、 丙烯酸與疏水單體之共聚物、含羧酸的單體與丙烯酸酯之 共聚物、丙烯酸與丙烯酸酯之交聯共聚物、雜多醣膠質及 晶形長鏈醯基衍生物。長鏈醯基衍生物係期望選自乙二醇 硬脂酸酯、具有16至22個碳原子之脂肪酸烷醇醯胺及其混 合物。乙二醇二硬脂酸酯及聚乙二醇三-二硬脂酸酯係較 佳的長鏈醯基衍生物，因為該等給予組合物珍珠光澤。聚 丙稀酸可購得Carbopol 420、Carbopol 488 或Carbopol 493 之商品。亦可使用與多官能性劑交聯的丙烯酸聚合物，該 等係可購得 Carbopol 910、Carbopol 934、Carbopol 941 及 Carbopol 980之商品。含羧酸單體與丙烯酸酯之合適共聚 物之實例為Carbopol 1342。所有Carbopol(商標名稱）物質 143422.doc -12- 201018494 係購自Goodrich 〇 丙烯酸及丙烯酸酯之合適交聯聚合物係pemulen 丁^或Plantaren 1200 and from Henkel: ^plantaren 2〇 (10). Other sugar-derived nonionic surfactants which may be included in the compositions of the present invention include Cl (rCl8 N-alkyl (C-C6) polyhydroxy fatty acid guanamines, such as c12-c18n-methyl glucosamine, which It is described, for example, in w〇92 〇6154 and us 5 194 639, and N-alkoxy polyhydroxy fatty acid decylamines, such as c10_Cl8 N-(3-methoxypropyl) glucosamine. Preferred examples are amphoteric or zwitterionic surfactants, the amount of which is from 3 to about 1% by weight, preferably from 1 to 6 parts by weight, based on the total weight of the composition of the composition. Examples of amphoteric or zwitterionic surfactants Including alkylamine oxides, alkylbetaines, alkylhamidopropyl betaines, alkyl sultaines, alkyl glycinates, alkylcarboxyglycinates, alkyl amphoacetates a salt, an alkyl amphoteric propionate, an alkyl amphoteric glycinate, an alkyl amidinopropyl hydroxy sulfobetaine, a decyl tauryl salt, and a decyl glutamate, wherein the alkyl group and the fluorenyl group The group has 8 to 19 carbon atoms. Typical amphoteric and zwitterionic surfactants used in the shampoos of the present invention include laurylamine. Oxide, coconut oil dimethyl sulfopropyl betaine, lauryl betaine coconut oil 醯 143422.doc 201018494 Aminopropyl betaine and sodium cocoamphoacetate. Particularly preferred amphoteric or zwitterionic surfactants are coconut It is also suitable for the mixture of any of the above amphoteric or zwitterionic surfactants. The preferred mixture is formed by cocoamidopropyl betaine with the other amphoteric or zwitterionic surfactants described above. A mixture of other preferred amphoteric or zwitterionic surfactants is sodium cocoamphoacetate. Φ Preferably, the hair care composition of the present invention is aqueous, that is, it contains water or an aqueous solution or a lyotropic liquid. The crystalHne) as its main component. Suitably, the composition comprises from 1% to 98% by weight, based on the total weight of the composition, of water 'preferably from 20 to 95% by weight. The composition according to the invention may comprise other polyfluorene oxide. Particularly preferred polyoxymethylene conditioning agents are polyoxo-oxygen emulsions, such as those formed by polyoxo-oxygen, such as polydiorganotoxime, in particular, CTFA name • dimethyl ketone (di Methoneone polydimethyl methoxy oxane, CTFA name dimethiconol polyhydroxy methoxy oxane having a hydroxyl end group, and particularly preferably CTFA name amino dimethyl ketone ( Amyl dimethicone having an amine functional group polydimethyl oxime. The emulsion droplets of the composition of the invention typically have a size of from 2 to 10 microns (more preferably from 0.2 to 10 microns). (Sauter) Average droplet diameter (〇3. A suitable method for measuring the Sauter's average droplet diameter (d3 2) is laser scanning using an instrument such as a Diffraction Laser Spectrometer (MalVern Mastersizer). 143422.doc 201018494 Suitable polyoxyl emulsions for use in the compositions of the present invention are available from polyoxyxylene suppliers such as Dow Corning and GE Silicones. Preferably, the pre-formed polyoxyn emulsion is used to facilitate processing and control of the particle size of the polyoxymethylene. Such preformed polyoxynoxy emulsions typically additionally comprise a suitable emulsifier (eg, an anionic or nonionic emulsifier, or mixtures thereof) and may be by chemical emulsification methods (eg, emulsion polymerization), or It was prepared by a mechanical emulsification method using a high shear mixer. Pre-formed polyoxo-oxygen emulsions having a Sauter average droplet diameter (D3.2) of less than 0.15 microns are generally referred to as microemulsions. Examples of suitable pre-formed polyoxo-emulsions include emulsions DC2-1766, DC-2-1784, DC-1785, DC-1786, DC-1788, and microemulsions DC2-1865 and DC2-1870 (all of which are available from Dow). Corning got) and HL999 or UL981 (available from Wacker). These are all emulsions of bismuth or microemulsion. Amino dimethyl ketone emulsions are also suitable, such as DC2-8177 and DC939 (from Dow Corning) and SME253 (available from GE Silicones). Some of the high molecular weight surface active block copolymer types of polyoxyn oxide emulsions which have been mixed with droplets of polyoxynized emulsion are also suitable, as described, for example, in WO 03/094874. Among the materials, the polyoxymethylene emulsion droplets are preferably formed by polydiorganotite (e.g., those as described above). One of the preferred surface active block copolymer forms is of the formula: H0(CH2CH20)x(CH(CH3)CH20)y(CH2CH20)xH wherein the average value of X is 4 or greater, and the average value of y is 25 or Bigger. Another preferred surface block copolymer form is as follows: (H0(CH2CH20)a)(CH(CH3)CH20)b)2-N-CH2-CH2-N((OCH2CH(CH3))b(〇 CH2CH2)aOH)2 143422.doc 201018494 wherein a has an average value of 2 or more, and b has an average value of 6 or more. Mixtures of any of the above polyoxygen emulsifiers can also be used. The polyoxyxide emulsion is usually present in the composition of the present invention in an amount of from 0.05 to 15% by weight based on the total weight of the hydrazine composition, preferably from 5% to 12% by weight of the total weight of the polyfluorene oxide. It is present in an amount of from 0.5 to 15% by weight, more preferably from 1 to 12% by weight. Other components that can be used in the composition are short chain glycols. Preferably, the short-chain diol has 3 to 7 carbon atoms and more preferably has 3 or 4 carbon atoms. More preferably, the short-chain diol is selected from the group consisting of 2-butanediol and hydrazine. 3-butyryl, 1,4-butanediol, iota, 2:propanol: alcohol, 1}3-propylene glycol, and mixtures thereof. More preferably, the short chain diol is selected from the group consisting of hydrazine, 3-butanediol and hydrazine, 2-propylene glycol. In a preferred embodiment, the short chain glycol is hydrazine, 3-butanediol. In a preferred embodiment, the compositions of the present invention comprise a cationic deposition polymer. Suitable cationic Hydrazine-assisted polymer homopolymers are either cationically substituted or formed from two or more types of monomers. The weight average molecular weight (Mw) of the polymer is usually between 100,000 and 2 Daltons. The polymer will have a cationic nitrogen-containing group such as a quaternary ammonium or protonated amine group, or a mixture thereof. If the molecular weight of the polymer is in the range, the conditioning effect is poor. Right too, may have a problem of high tensile viscosity, which, when poured out, causes the composition to become silky. The cationic nitrogen-containing group is usually a substituent which is a part of the total monomer unit of the cationic polymerization 143422.doc 201018494. Thus when the polymer is not a homopolymer it may contain a spacer non-cationic monomer unit. These polymers are described in the CTFA Cosmetic Infredient Directory, third edition. The ratio of cationic to non-cationic units is selected to produce a polymer having a cationic charge density within the desired range, which is typically from 0.2 to 3 〇 meq/gm. The cationic charge density of the polymer is preferably determined by the Kjeldahl method in the chemical test for nitrogen determination as described in the US Pharmac〇p〇eia. Suitable cationic polymers include, for example, vinyl monomers having a cationic amine or a quaternary ammonium functional group with a water soluble spacer monomer (eg, (meth) acrylamide, alkyl and dialkyl (methyl) a copolymer of acrylamide, alkyl (meth) acrylate, vinyl caprolactone and vinyl pyrrolidine). The monomer substituted with a mercapto group and a dialkyl group preferably has a C1_C7 alkyl group, more preferably a C1_3 alkyl group. Other suitable separators include vinyl esters, vinyl alcohol, maleic anhydride, propylene glycol, and ethylene glycol. The cationic amine can be a primary, secondary or tertiary amine, depending on the particular species and pH of the composition. In general, secondary and tertiary amines, especially tertiary amines, are preferred. The amine-substituted vinyl monomer and amine can be polymerized as an amine and then converted to ammonium by quaternization. The cationic polymer may comprise a mixture of monomer units derived from a monomer substituted with an amine and/or a quaternary acid and/or a monomer which may coexist. Suitable cationic polymers include, for example: - polymers containing cationic diallyl quaternary ammonium, including, for example, 'dimercaptodipropyl propylene gasification homopolymer and propylamine and two 143,422.doc • 10-201018494 Copolymer of methyl diallyl ammonium hydride, known in the industry (CTFA) as P〇lyquaternium 6 and polyquaternium 7 respectively; - 3 to 5 carbons a mineral acid salt of an atomic unsaturated carboxylic acid and an amine-alkyl ester of a copolymer (described in U.S. Patent No. 4,009,256 t); - a cationic polypropylene decylamine (described in W095/22311) ). Other cationic polymers that may be used include cationic polysaccharide polymers such as cationic cellulose derivatives, cationic starch derivatives, and cationic Guanzhi gum derivatives. Cationic polysaccharide polymers suitable for use in the compositions of the present invention include monomers of the formula: A-0-[R-N+(R1)(R2)(R3)x-] wherein: A is an anhydroglucose residue' : Temple powder or cellulose dehydrated glucose residue. R is an alkylene group, an oxyalkylene group, a polyalkylene group, or a cis alkyl group, or a combination thereof. R1, R2 and R3 independently of one another represent an alkyl, aryl, alkaryl, aralkyl, alkoxyalkyl or alkoxyaryl group, each group containing up to about 18 carbon atoms. The total number of carbon atoms of each cationic moiety ' (i.e., the total number of carbon atoms in R1, R2, and R3) is preferably about 2 Å or less, and X is an anionic counter ion. Another class of cationic celluloses includes polymeric quaternary salts formed by the reaction of hydroxyethyl cellulose with an epoxide substituted with dimethyl ammonium laurate, referred to in the industry (CFTA) as the polyquaternary salt 24. Such materials are available from Amerch(R) 1 Corporation, for example under the trade name Polymer LM-200. 143422.doc 11 201018494 Other suitable cationic polysaccharide polymers include cellulose ethers containing a quaternary nitrogen (for example, as described in U.S. Patent No. 3,962,418), and copolymers of etherified cellulose and starch (for example, as described in U.S. Patent. 3,958,581). A cationic polysaccharide polymer type which is particularly suitable for use is a cationic Guanhua bean gum derivative such as Guanhua bean gum hydroxypropyltrimonium chloride (purchased from Rhodia in the JAGUAR trade name series). Examples of such materials are JAGUAR C13S, JAGUAR C14, JAGRARC15 and JAGUAR C17. A mixture of any of the above cationic polymers can be used. The cationic polymer is typically present in the shampoo compositions of the present invention at a total weight of from 0.01 to 5%, preferably from 0.05 to 2%, more preferably from 0.07 to 1.2%, by weight based on the total weight of the composition. Preferably, the aqueous shampoo compositions of the present invention may further comprise a suspending agent. Suitable suspending agents are selected from the group consisting of polyacrylic acid, crosslinked polymers of acrylic acid, copolymers of acrylic acid and hydrophobic monomers, copolymers of carboxylic acid containing monomers and acrylates, crosslinked copolymers of acrylic acid and acrylate, and heteropolysaccharides. Colloidal and crystalline long chain mercapto derivatives. The long chain mercapto derivative is desirably selected from the group consisting of ethylene glycol stearate, a fatty acid alkanolamine having 16 to 22 carbon atoms, and a mixture thereof. Ethylene glycol distearate and polyethylene glycol tristearate are preferred long chain mercapto derivatives because of the pearl luster imparted to the compositions. Polyacrylic acid is commercially available as Carbopol 420, Carbopol 488 or Carbopol 493. It is also possible to use an acrylic polymer crosslinked with a polyfunctional agent which is commercially available as Carbopol 910, Carbopol 934, Carbopol 941 and Carbopol 980. An example of a suitable copolymer of a carboxylic acid containing monomer and an acrylate is Carbopol 1342. All Carbopol (trade name) substances 143422.doc -12- 201018494 are purchased from Goodrich 〇 Acrylic acid and acrylate suitable cross-linked polymer system pemulen Ding ^ or
Pemulen TR2。合適的雜多醣膠質係三仙膠，例如可購得 之Kelzan mu商品。 可使用以上任何-種懸浮劑之混合物。較佳為丙烤酸之 交聯聚合物與晶形長鏈醯基衍生物的混合物。 懸浮劑一般將以占組合物總重量之〇丨至1〇%，較佳〇5 至6%，更佳0.9至之懸浮劑總量存在於本發明洗髮精組 合物中。 可用於本發明組合物之另一組份為碳氫化合物油或酯 油。如同聚碎氧油，該等物質亦可増強本發明組合物中所 發現之調理效果。 合適碳氩化合物油具有至少12個碳原子，且包括石蠟 油、聚稀㈣、礦物質；由、飽和及不飽和十二碳烧、飽和 及不飽和十二碳烧、飽和及不飽和十四碳垸、飽和及不飽 ❿ 和十五碳烷、飽和及不飽和十六碳烷、及其混合物，亦可 使用該等化合物與較高鍵長度的碳氯化合物之分支鍵異構 物。Gw烯基單體之聚合碳氫化合物亦合適，例如聚異丁 烯。 合適醋油具有至少10個碳原子，且包括具有衍生自脂肪 酸或醇的烴基鏈之醋類。典型醋油通式為r，c〇〇r，其中 R，及R獨立地表示烧基或稀基，及r，ar中之碳原子總數為 至少1〇,較佳為至少20。亦可使用叛酸之二及三烧基及 稀基S旨。 143422.doc 13- 201018494 較佳脂肪油為單-、二-及三酸甘油酯，更明確言之為具 有長鏈羧酸（如：Cl·22羧酸）之甘油之單-、二-及三-酯。該 等物質之實例包括可可奶油、硬棕櫚油、葵花油、大豆油 及挪子油。 亦可使用上述住何一種碳氫化合物/酯油之混合物。 本發明組合物中碳氫化合物油及酯油之總組合量宜占組 合物重量之0.05至1〇%，特別為0.2至5% ’且尤佳為〇 5至 3%。 本發明組合物可包含其它用於增強效能及/或消費者可 接受度之成份。該等成份包括芳香劑、染料及顏料、pH調 節劑、珍珠光澤劑或不透明劑、黏度改質劑、及防腐劑或 抗微生物劑。各該等成份將以完成達到其目的之有效量存 在。通常各該等可選成份含量係分別至高占總組合物重量 之5 %。 較佳地，黏調濃縮洗髮精係在真空下製備。較佳地，該 方法在〇.5至1〇巴真空下進行，更佳為0.8M巴之真空。 本發明進一步藉由以下非 非限制實例說明，其中所有引用 的百分比係基於總重量之重吾0/ 夂篁量/。计，除非另有其他說明。 實例1 以下調配物係如本發明。Pemulen TR2. A suitable heteropolysaccharide gum system is Sanxian gum, such as the commercially available Kelzan mu product. Mixtures of any of the above suspending agents can be used. Preferably, a mixture of a cross-linked polymer of a propene acid and a long-chain mercapto derivative of a crystalline form is used. The suspending agent will generally be present in the shampoo compositions of the present invention in an amount of from 〇丨 to 1% by weight, preferably from 〇5 to 6%, more preferably from 0.9 to the total amount of the suspending agent. Another component which can be used in the compositions of the present invention is a hydrocarbon oil or an ester oil. Like polyoxygenated oils, such materials may also predispose the conditioning benefits found in the compositions of the present invention. Suitable carbon argon compound oils have at least 12 carbon atoms and include paraffin oil, poly (tetra), minerals; from, saturated and unsaturated 12 carbon burned, saturated and unsaturated 12 carbon burned, saturated and unsaturated 14 Carbonium, saturated and unsaturated, and pentadecane, saturated and unsaturated hexadecane, and mixtures thereof, may also be used as a branched bond isomer of a higher bond length chlorocarbon. Polymeric hydrocarbons of Gw alkenyl monomers are also suitable, such as polyisobutylene. Suitable vinegar oils have at least 10 carbon atoms and include vinegars having a hydrocarbyl chain derived from a fatty acid or an alcohol. Typical vinegar oils are of the formula r, c〇〇r, wherein R, and R independently represent an alkyl or a dilute group, and the total number of carbon atoms in r, ar is at least 1 Torr, preferably at least 20. It is also possible to use the second and third bases of the tartrate and the base. 143422.doc 13- 201018494 Preferred fatty oils are mono-, di- and triglycerides, more specifically single-, di- and glycerols with long-chain carboxylic acids (eg Cl.22 carboxylic acid) Tri-ester. Examples of such materials include cocoa butter, hard palm oil, sunflower oil, soybean oil, and raspberry oil. It is also possible to use a mixture of any of the hydrocarbon/ester oils mentioned above. The total combined amount of the hydrocarbon oil and the ester oil in the composition of the present invention is preferably from 0.05 to 1% by weight, particularly from 0.2 to 5%', and particularly preferably from 5% to 3% by weight based on the weight of the composition. The compositions of the present invention may contain other ingredients for enhancing efficacy and/or consumer acceptability. Such ingredients include fragrances, dyes and pigments, pH adjusters, pearlescent or opacifying agents, viscosity modifiers, and preservatives or antimicrobials. Each of these components will be present in an amount effective to achieve its purpose. Typically, each of these optional ingredients is present at a level up to 5% by weight of the total composition. Preferably, the viscous concentrated shampoo is prepared under vacuum. Preferably, the method is carried out under a vacuum of 〇5 to 1 Torr, more preferably a vacuum of 0.8 mbar. The invention is further illustrated by the following non-limiting examples in which all percentages quoted are based on the weight of the total weight. Unless otherwise stated. Example 1 The following formulations are as in the present invention.
143422.doc 14· 201018494 胺基聚矽氧* 1.2 二曱石夕酮* * * 2.5 聚丙二醇** 2.0 香料 2.5 顏料 視需要 pH調節劑 視需要 氣化納 2.0 水 q.s. *胺基聚矽氧係經胺基官能化PDMS曱氧基封端，SLM2901，來 自 Wacker ** PPG425 ’ 來自 Dow Corning *** HL 999，來自 wacker 實例2 以下方法係用於製備如實例1之組合物。 1·於副容器的熱水（70至75。(：）中製備EDTA2Na、L-離胺睃 及氯化鈉之混合物，其中水與氣化鈉最小比值為3:1， 以充分溶解氣化鈉。 2·保持溫度在70至75°C以熔化CMEA。然後饋入CMEA至 副混合器中。全部於70至75°C混合且在熱條件下轉移 至主容器中。 3.依兩個步驟分開SLES1EO。第一階段僅使用1重量％， 以形成含CMEA之乳脂狀底質。高量SLES1EO會造成 CMEA固化。剩餘之SLES1EO將透過高速均質器饋入。 自此步驟開始打開真空。均質化後，停止再循環。僅 需要攪拌器及刮板。 4·饋入PPG 425、CAPB、染料溶液至主混合器中。其均 143422.doc 15 201018494 ’以確保產物均 此步驟產物仍然 分開饋入’且需要高速攪拌器及刮板 句混合。然後打開真空以消除氣泡。 為乳脂狀，且沒有明顯的黏性。 饋入聚矽氧HL29 座初轉變為黏性，且升 成結構體。在此階段中需要高速授拌器及刮板。需； 請至K0巴之真空，卩消除㈣之氣泡，且 氣產物。 μ 6.饋入一甲梦嗣。在此步帮中 件0 維持如步驟5之同樣條143422.doc 14· 201018494 Aminopolyoxyl* 1.2 Diterpenoids* * * 2.5 Polypropylene glycol** 2.0 Perfume 2.5 Pigment pH adjustment agent as needed Gasification nano 2.0 water qs * Amine polyoxyl system Amino-functionalized PDMS oxime-terminated, SLM2901 from Wacker ** PPG 425 'from Dow Corning *** HL 999 from wacker Example 2 The following procedure was used to prepare a composition as in Example 1. 1. Prepare a mixture of EDTA2Na, L-aminide and sodium chloride in the hot water of the sub-tank (70 to 75. (:), wherein the minimum ratio of water to vaporized sodium is 3:1 to fully dissolve the gasification Sodium 2. Keep the temperature at 70 to 75 ° C to melt the CMEA. Then feed the CMEA into the secondary mixer. Mix all at 70 to 75 ° C and transfer to the main vessel under hot conditions. The procedure separates SLES1EO. The first stage uses only 1% by weight to form a creamy substrate containing CMEA. A high amount of SLES1EO will cause the CMEA to solidify. The remaining SLES1EO will be fed through a high speed homogenizer. The vacuum is opened from this step. After the reaction, the recirculation is stopped. Only the agitator and the scraper are needed. 4. Feed the PPG 425, CAPB, and dye solution into the main mixer. All of them are 143422.doc 15 201018494 'to ensure that the products are still fed separately. Into the 'high-speed stirrer and scraper sentence mixing. Then open the vacuum to eliminate air bubbles. It is creamy, and there is no obvious viscosity. Feeding the poly-n-oxide HL29 seat is initially transformed into viscous and raised into a structure. High speed agitator and scraper are required at this stage Required; go to the vacuum bar K0, (iv) the Jie eliminate air bubbles, and the gas fed into a product μ 6. A dream Si in this step to help maintain the member 0 as in step 5 of the same article.
7.將經混合的關華豆膠分散 队仕蚋谷1§中的香料中。然後 慢慢饋入至主混合器中。 產物相當的黏稍。因此堂· & 词囚此需要高速攪拌器及刮板。需要 0 ·8 0至1 · 〇巴之真空，以消哈名、& 以肩除軋泡，並且形成無空氣產物。7. Disperse the mixed Guanhua bean gum in the spices of the team Shigu 1 §. Then slowly feed it into the main mixer. The product is quite sticky. Therefore, the Hall & word requires a high speed agitator and scraper. A vacuum of 0 · 80 0 to 1 · 〇巴 is required to remove the foam and to form an airless product.
143422.doc 16.143422.doc 16.