Claims (1)
201006503 七、申請專利範圍： 1. 一種含有游離或鹽型鹼性胺基酸之組成物，該驗性胺 基酸係被嵌入生物可钱性聚合物。 2. 如申請專利範圍第1項之組成物，其中該生物可敍性 聚合物係選自聚(乳酸）、聚（乙醇酸)和共聚物；聚二噚 酮、聚(麩胺酸乙酯）、聚(羥基丁酸酯）、聚(羥基戊酸醋） 和共聚物；聚己内酯、聚酸酐、聚(原酸酯）、聚(亞胺基 碳酸酯）、聚酯醢胺類、聚酯胺類、聚氰丙烯酸醋類、 聚磷腈類’共聚物及其他脂族聚酯，或其適當共聚物包 括聚-L-乳酸和聚ε -己内酯的共聚物、血纖維蛋白、膠 原蛋白、葡萄胺聚醣（glyCOS〇amin〇glyCan)、募醣、多 膽、軟骨素、聚葡萄胺糖（chit〇san)、褐藻酸酯、纖維 蛋白（fibring)、纖維蛋白原、纖維素、澱粉、葡聚糖、 糊精、破尿酸、肝素、彈性蛋白；多嵌段共聚物例如建 構自乙交酯、丙交酯、己内酯的基礎單位；以及聚 乙—醇和聚（酯-醯胺）聚合物或類似物，其以白胺酸、苯 丙胺酸及/或精胺酸為基礎，選擇地具有一或多種二元醇 類和—或多種二甲酸類。 3· 一種組成物’其包括具有孔隙之支架及存在該孔隙間 之鹼性胺基酸。 4. 如申清專利範圍第3項之組成物，其中該支架係塑膠。 5. 如申清專利範圍第3或4項之組成物，其中該支架係 選自聚乙締、聚甲基丙烯酸曱酯、聚胺基曱酸酯、聚乙 21 201006503 烯對苯二曱酸酯、聚丙烯、聚苯乙烯、聚醯胺類、生物 塑膠、生物可降解塑膠，及其組合。 6. 如申請專利範圍第3〜5項中任一項之組成物，其中該 鹼性胺基酸可逆地存在於該孔隙間。 5 7. 如上述申請專利範圍中任一項之組成物，其中該鹼性 胺基酸係精胺酸、離胺酸、瓜胺酸、鳥胺酸、肌酸、 組胺酸、二胺基丁酸、二胺基丙酸，其鹽及/或其組 合。 8. 如上述申請專利範圍中任一項之組成物，其中該鹼性 ίο 胺基酸具有L-構型。 9. 如上述申請專利範圍中任一項之組成物，其中該鹼性 胺基酸係精胺酸。 10. 如上述申請專利範圍中任一項之組成物，其中該驗性 胺基酸係L-精胺酸。 15 11.如上述申請專利範圍中任一項之組成物，其包含鹽型 的驗性胺基酸。 12. 如上述申請專利範圍中任一項之組成物，其包含精胺 酸磷酸鹽。 13. 如上述申請專利範圍中任一項之組成物，其包含精胺 20 酸鹽酸鹽。 14. 如上述申請專利範圍中任一項之組成物，其包含一精 22 ❹ 10 參 15 201006503 胺酸鹽及一陰離子聚合物。 15.如上述申請專利範圍中任一項之組成物，其包含 酸碳酸氫鹽。 16· -種裝置’其包括使用如中請專利範圍第卜15項中 任一項之組成物塗佈之器具。 17. :::專利範圍第16項之裝置，其中該器具係包括 18. 第17項之裝置，其中該鬃毛被如申 π專利範圍第卜15項中任一項之組成物塗佈。 19. 利範圍第17或18項之裝置，其中該頭部被 申❺專利範圍第1〜15項中任—項之組成物塗佈。 Γ如申請專利範圍第16項之裝置，其中該器具係牙藏。 利範圍第16項之裝置，其中該器具係舌答 22. :=:圍表=裝置，其中該舌答清潔器包 項細如巾請專利範圍第 上5項中任一項之組成物塗佈。 币 23. 如申請專利範圍第16項之裝置 膠。 ，、T通器具係護口 4.如申請專利範圍第16項之裝 矯正裝置。 Μ其中該益具係牙齒 23 20 201006503201006503 VII. Scope of Application: 1. A composition containing a free or salt-type basic amino acid embedded in a bio-nicifiable polymer. 2. The composition of claim 1, wherein the biorepresentable polymer is selected from the group consisting of poly(lactic acid), poly(glycolic acid) and copolymer; polydioxanone, poly(ethyl glutamate) ), poly(hydroxybutyrate), poly(hydroxyvalerate) and copolymer; polycaprolactone, polyanhydride, poly(orthoester), poly(iminocarbonate), polyester decylamine , polyesteramines, polycyanoacrylates, polyphosphazenes' copolymers and other aliphatic polyesters, or suitable copolymers thereof, including copolymers of poly-L-lactic acid and poly-ε-caprolactone, blood fibers Protein, collagen, glycosaminoglycan (glycos〇amin〇glyCan), sugar-raising, polybiliary, chondroitin, chit〇san, alginate, fibring, fibrinogen, Cellulose, starch, dextran, dextrin, uric acid, heparin, elastin; multi-block copolymers such as base units constructed from glycolide, lactide, caprolactone; and polyethyl alcohol and poly( An ester-guanamine polymer or analog, optionally based on leucine, phenylalanine and/or arginine Or more diols and class - or more dicarboxylic Acid. 3. A composition comprising a scaffold having pores and a basic amino acid present between the pores. 4. If the composition of the third paragraph of the patent scope is claimed, the bracket is plastic. 5. The composition of claim 3 or 4, wherein the stent is selected from the group consisting of polyethyl amide, polymethyl methacrylate, polyamino phthalate, polyethyl 21 201006503 olefin terephthalic acid Ester, polypropylene, polystyrene, polyamines, bioplastics, biodegradable plastics, and combinations thereof. 6. The composition of any one of claims 3 to 5, wherein the basic amino acid is reversibly present between the pores. The composition according to any one of the preceding claims, wherein the basic amino acid is arginine, lysine, citrulline, ornithine, creatine, histidine, diamine Butyric acid, diaminopropionic acid, salts thereof and/or combinations thereof. 8. The composition of any of the preceding claims, wherein the basic ίο amino acid has an L-configuration. A composition according to any one of the preceding claims, wherein the basic amino acid is arginine. A composition according to any one of the preceding claims, wherein the testable amino acid is L-arginine. A composition according to any one of the preceding claims, which comprises a salt-type test amine acid. A composition according to any one of the preceding claims, which comprises arginine phosphate. A composition according to any one of the preceding claims, which comprises a spermine 20 acid salt. 14. The composition of any of the preceding claims, comprising a fine 22 ❹ 10 gin 15 201006503 aminate and an anionic polymer. A composition according to any one of the preceding claims, which comprises an acid hydrogencarbonate. A device comprising a device coated with a composition according to any one of the above-mentioned patents. 17. The device of claim 16, wherein the device comprises the device of item 17, wherein the bristles are coated with a composition according to any one of the claims of claim 516. 19. The device of item 17 or 18, wherein the head is coated with a composition of any one of items 1 to 15 of the patent application. For example, the device of claim 16 of the patent application, wherein the device is a dental device. The device of claim 16, wherein the device is a tongue and a tongue. 22. :=: a wall-mounted device, wherein the tongue-and-stick cleaner item is as thin as a towel, and the composition of any one of the fifth items of the patent scope is coated. cloth. Coin 23. For example, apply for the device glue in item 16 of the patent scope. , T Tong appliance system protection mouth 4. If the application of the scope of the scope of the article 16 correction device. ΜThe benefit of the teeth is 23 20 201006503
25. 5 10 一種方法，复·^ 橡姑+ ,丹了(1)減少或抑制蛀牙的形成；（ii)減少、 P制早期琺螂質病變，例如藉由定量光激發螢光 =)或電鶴齒測量法(ECM)的測定；⑽減少或抑制 的去礦化及促進再礦化；（iv)減少牙齒過敏性 K或抑制齒酿炎；（vi)促進口腔内潰瘍或傷口的癒 ~ ( ii)降低產酸菌的濃度·，（viii)增加精胺酸溶解菌 的相對濃度·’（IX)抑制口腔内微生物生物顏形成；⑻ 甜食之後上升及/或維持牙垢pH在至少5 5的程 度，。(XI)減少牙垢的積聚；（xii)治療、緩和或減少口腔 乾燥；（X111)清潔牙齒和口腔；（xiv)減少腐姓；㈣使 牙齒變白；（XVI)使牙齒對致齲菌免疫；及/或(xvii)促進 包括心血官的身體健康’例如藉由降低經由口腔組織全25. 5 10 A method, complex ^ ^ aunt +, Dan (1) reduce or inhibit the formation of caries; (ii) reduce, P system early enamel lesions, such as by quantitative light to stimulate fluorescence =) or Determination of electric crane measurement (ECM); (10) reduction or inhibition of demineralization and promotion of remineralization; (iv) reduction of tooth hypersensitivity K or inhibition of tooth brewing; (vi) promotion of oral ulcers or wound healing ~ ( ii) reduce the concentration of acid-producing bacteria ·, (viii) increase the relative concentration of arginine-dissolving bacteria · '(IX) inhibit the formation of microbial bio-forms in the mouth; (8) rise after the sweets and / or maintain the pH of the tartar at least 5 The extent of 5,. (XI) reduce the accumulation of tartar; (xii) treat, alleviate or reduce dry mouth; (X111) clean teeth and mouth; (xiv) reduce rot; (4) whiten teeth; (XVI) make teeth immune to sputum And/or (xvii) promote the physical health of the heart, including by reducing the entire organization through the mouth
身性感染的可能性’其包含使用__口腔裝置，該裝置包 含驗性胺基酸，其係板據個人的需要。 15 26. 27. 28. 如申請專利範圍第25項之方法，其帽裝置係一種 如申請專利範圍弟16〜24項中任一項之裝置。 —種鹼性胺基酸於製造牙齒裝置之用途。 如申請專利範圍第27項之用途，其中該裝置係一種 如申請專利範圍第16〜24項中任一項之裝置。 24 201006503 四、指定代表圖： (一) 本案指定代表圖為：第（無）圖。 (二) 本代表圖之元件符號簡單說明： 無 五、本案若有化學式時，請揭示最能顯示發明特徵的化學式： 無 201006503 發明糞利說明書 98J9The possibility of a body infection' which involves the use of a __oral device containing an indicating amino acid, which is tied to the individual's needs. 15 26. 27. 28. The method of claim 25, wherein the cap device is a device as claimed in any one of claims 16 to 24. - The use of a basic amino acid for the manufacture of dental devices. The apparatus of claim 27, wherein the apparatus is a device as claimed in any one of claims 16 to 24. 24 201006503 IV. Designation of representative drawings: (1) The representative representative of the case is: (No). (2) A brief description of the symbol of the representative figure: None 5. If there is a chemical formula in this case, please disclose the chemical formula that best shows the characteristics of the invention: None 201006503 Inventive manure instruction 98J9
(本說明書格式、順序，請勿任意更動，※記號部分請勿填寫） ※申請案號： ※申請曰： 分類： 、發明名矛冉.（中文/英文） 組成物及裝置（二） COMPOSITIONS AND DEVICES 二、中文發明摘要： 本發明提供包含鹼性胺基酸的口腔器具及製造此類11 具的組成物，以及製造和使用此類器具的方法。 ©三、英文發明摘要： The present invention provides oral instruments comprising a basic amino acid, to compositions for making such instruments, and to methods of making and using such instruments. 1 201006503 六、發明說明： 此專利申請案主張擁有2008年2月8曰提出之美國專 利申請案序號61/027,428的權利，藉由引述將其内容併入 於此。 八 【發明所屬之技術領域】 本發明提供包含鹼性胺基酸的口腔器具及製造此類器 具的組成物，以及製造和使用此類器具的方法。 ° 【先前技術】 已建議使用精胺酸和其他鹼性胺基酸於口腔保健以及 涊為其在對抗齲齒形成和牙齒敏感具有顯著效益。已認為 口腔内鹼性胺基酸被某些非生齲齒類型細菌例如血鏈球菌 (S· sanguis)所代謝，其將與口腔内牙齒的生齲齒菌例如變異 鏈球菌（S. mutans)產生競爭作用❶精胺酸溶解菌能利用精胺 酸和其他鹼性胺基酸產生氨而提高環境pH，同時齲齒菌則 將糖代謝成乳酸而降低牙斑pH和使牙齒去礦化，最後造成 ^^齒。 使用精胺酸處理口腔’目前係以牙粉（dentifrice )組 成物例如DenClude®來完成。亦建議以精胺酸配製成食物和 飲料產品。雖然經處理例如刷牙、P且嚼口香糖或吃富含精 胺酸食物之後精胺酸的有益效應可在口腔内持續數分鐘或 數小時之久’但是較佳為發展可傳遞精胺酸至口腔的其他 組成物和裝置，例如協同含精胺酸的組成物，或單獨。 用於口腔的器具已為技術領域中所熟知及包括例如牙 3 201006503 刷、刮舌器、牙線、牙籤、護口膠（mouth guard )，以及牙 齒矯正裝置例如牙套和固位器。此類器具雖然可被鹼性胺〆 基酸所處理，但是該鹼性胺基酸可能產生滲漏或侵蝕該器 ’ 具表面而需要費時地重複處理並且對使用者而言極不方 便。此類器具的處理亦可能極為複雜，並且不完全或不正 確的處理可能導致過少或過多的鹼性胺基酸被併入該器具 的表面。因此亟需創造可克服這些困難的組成物、裝置和 方法。 ❹ 【發明内容】 本發明係關於能將鹼性胺基酸如精胺酸傳遞至口腔的 組成物及裝置其用於例如⑴減少或抑制姓牙的形成；（^) 減少、修補或抑制早期琺瑯質病變，例如藉由定量光激發 螢光(QLF)或電齲齒測量法(ECM)的測定；（iii)減少或抑制 牙齒的去礦化及促進再礦化；（iv)減少牙齒過敏性；（v)減 少或抑制齒齦炎；（vi)促進口腔内潰瘍或傷口的癒合；（vii) 降低產酸菌的濃度；（viii)增加精胺酸溶解菌的相對濃度；❹ (ix)抑制口腔内微生物生物膜的形成；（x)使牙垢pH上升 及/或維持在至少pH 5.5的程度；（xi)減少牙垢的積聚；（xii) 清潔牙齒和口腔；（xiii)治療口腔乾燥；（xiv)改善身體健 康；及/或(xv)使牙齒變白。可單獨使用此類的組成物和裝 置或協同3其他驗性胺基酸的組成物如牙粉組成物以傳遞 驗性胺基酸至口腔。 本發明因此包含組成物1.0的一種包括嵌入生物可蝕 性（bioerodable)聚合物内之鹼性胺基酸的組成物。 201006503 本發明亦包括下列的組成物： 1.1組成物1.0其中該鹼性胺基酸係精胺酸、離胺酸、瓜胺 酸、鳥胺酸、肌酸、組胺酸、二胺基丁酸、二胺基丙 酸，其鹽及/或其組合。 1,2組成物I·0或U其中該鹼性胺基酸具有L-構型。 1.3任何上述組成物其中該鹼性胺基酸係精胺酸。 1.4任何上述組成物其中該鹼性胺基酸係^精胺酸。 m(Please do not change the format and order of this manual, please do not fill in the ※ part) ※Application number: ※Application曰: Classification: Invented name spear. (Chinese/English) Composition and device (2) COMPOSITIONS AND DEVICES II. Abstract of the Invention: The present invention provides an oral appliance comprising a basic amino acid and a composition for the manufacture of such an article, and a method of making and using such an appliance. ©3, English Abstract: The present invention provides oral instruments comprising a basic amino acid, to compositions for making such instruments, and to methods of making and using such instruments. 1 201006503 VI. Description of the invention: This patent application claims to have 2008 The rights of U.S. Patent Application Serial No. 61/027,428, filed on Jan. VIII Technical Field to Which the Invention The present invention provides an oral appliance comprising a basic amino acid and a composition for manufacturing the same, and a method of manufacturing and using the same. ° [Prior Art] It has been suggested that arginine and other basic amino acids are used in oral care and that sputum has significant benefits in combating caries formation and tooth sensitivity. Oral basic amino acids have been thought to be metabolized by certain non-carious bacteria, such as S. sanguis, which will compete with the dental caries of the oral cavity, such as S. mutans. The action of arginine-dissolving bacteria can increase the environmental pH by using arginine and other basic amino acids to produce ammonia, while the caries bacteria metabolize the sugar to lactic acid to lower the plaque pH and demineralize the teeth, resulting in ^ ^ teeth. Treatment of the oral cavity with arginine is currently done with a dentifrice composition such as DenClude®. It is also recommended to formulate food and beverage products with arginine. Although the beneficial effects of arginine after treatment such as brushing, P and chewing gum or eating a diet rich in arginine may last for a few minutes or hours in the mouth 'but better development can deliver arginine to the oral cavity Other compositions and devices, such as synergistic compositions containing arginine, or alone. Appliances for the oral cavity are well known in the art and include, for example, teeth 3 201006503 brushes, tongue scrapers, dental floss, toothpicks, mouth guards, and dental correction devices such as braces and retainers. While such an appliance can be treated with a basic amine hydrazinoic acid, the basic amino acid may leak or erode the surface of the apparatus requiring time consuming repetitive treatment and is extremely inconvenient for the user. The handling of such devices can also be extremely complex, and incomplete or improper handling can result in too little or too much alkaline amino acid being incorporated into the surface of the device. There is therefore a need to create compositions, devices and methods that overcome these difficulties. SUMMARY OF THE INVENTION The present invention relates to a composition and apparatus capable of delivering a basic amino acid such as arginine to the oral cavity for use in, for example, (1) reducing or inhibiting the formation of a tooth; (^) reducing, repairing or inhibiting early珐琅 lesions, such as by quantitative photo-excited fluorescence (QLF) or electro-tooth measurement (ECM); (iii) reducing or inhibiting demineralization of teeth and promoting remineralization; (iv) reducing tooth hypersensitivity; (v) reduce or inhibit gingivitis; (vi) promote oral ulcer or wound healing; (vii) reduce the concentration of acidogenic bacteria; (viii) increase the relative concentration of arginine-dissolving bacteria; ❹ (ix) inhibit oral cavity (x) increasing the pH of the plaque and/or maintaining it to at least pH 5.5; (xi) reducing the accumulation of tartar; (xii) cleaning the teeth and mouth; (xiii) treating the dry mouth; (xiv Improve your health; and/or (xv) whiten your teeth. Such compositions and devices may be used alone or in combination with other compositions of a testeric acid such as a dentifrice composition to deliver an amino acid to the oral cavity. The invention thus comprises a composition of composition 1.0 comprising a basic amino acid embedded in a bioerodable polymer. 201006503 The present invention also includes the following compositions: 1.1 Composition 1.0 wherein the basic amino acid is arginine, lysine, citrulline, ornithine, creatine, histidine, diamine butyric acid , diaminopropionic acid, salts thereof and/or combinations thereof. 1, 2 Composition I·0 or U wherein the basic amino acid has an L-configuration. 1.3 Any of the above compositions wherein the basic amino acid is arginine. 1.4 Any of the above compositions wherein the basic amino acid is arginine. m
1.5任何上述組成物包含鹽型的鹼性胺基酸。 1.6任何上述組成物包含精胺酸磷酸鹽。 1.7任何上述組成物包含精胺酸鹽酸鹽。 1.8任何上述組成物包含精胺酸硫酸鹽。 1.9任何上述組成物包含精胺酸碳酸氫鹽。 1.10任何上述組成物其中該生物可蝕性聚合物係選自聚 (乳酸）、聚（乙醇酸)和共聚物；聚二畤酮、聚(麵胺酸乙 酯）、聚(羥基丁酸酯）、聚(羥基戊酸酯)和共聚物；聚己 内酯、聚酸酐、聚(原酸酯）、聚（亞胺基碳酸酯）、聚酯 醯胺類、聚酯胺類、聚氰丙烯酸酯類、聚磷腈類，共 聚物及其他脂族聚酯，或其適當共聚物包括聚-L-乳酸 和聚ε-己内醋（e-caprolactone)的共聚物、血纖維蛋 白（fibrin )、膠原蛋白、葡萄胺聚醣 (glycosoaminoglycan )、募醣、多醣、軟骨素、聚葡 萄胺糖（chitosan)、褐藻酸酯、纖維蛋白（faring)、纖 維蛋白原、纖維素、澱粉、葡聚糖、糊精、玻尿酸、 肝素、彈性蛋白；多嵌段共聚物例如建構自乙交酯、 5 201006503 丙交S曰、ε _己内酯的基礎單位；以及聚乙二醇和聚（酯 或類似物’以白胺酸、苯丙胺酸及/或精 月女酸為基礎’選擇地具有—或多種二元醇類和一或多 種二甲酸類。 1’11任何下文中組成物進—步包含存在於孔隙内的的氣化 孤例如選自氟化亞錫、氟化納、氟化卸、單氟磷酸 納敗石夕酸納、氟梦酸銨、氟化胺、氟化錢，及其組 合。 1.12任=下文中組成物進一步包含抗菌劑選自三氣沙；草 本萃取物和精油(例如迷迭香萃取物、茶樹萃取物、木 蘭萃取物、瑞香酚、薄荷醇、桉葉醇、香葉醇、香芹 酚、檸檬醛、檜木醇、兒茶酚、甲基水揚酸、表沒食 子兒茶素沒食子酸酯（epigall〇catechin gaiiate)、表沒 食子兒茶素、沒食子酸、碧桃茉莉萃取物、沙棘 (sea-buckthorn)萃取物、蜂膠）；雙胍抗菌劑(例如沙威 隆（chlorhexidine)、阿立西定（alexidine)或奥替尼啶 (octenidine));季銨化合物（例如氣化錄躐基吡咬 (CPC)、氯化苄烧敍、氯化十四烧基吡咬(TpC)、氣化 N-十四烷基-4-乙基吡。定(TDEPC));苯酚殺菌劑；海克 西定(hexetidine);奥替尼咬；血根驗；優蛾；地莫匹 醇(delmopinol) ; salifluor ;金屬離子(例如鋅鹽如擰樣 酸鋅、亞錫鹽、銅鹽、鐵鹽）；血根鹼(sanguinarine); 蜂膠和氧化劑(oxygenating agent)(例如過氧化氫、、緩 衝過氧硼酸鈉或過氧碳酸鈉）；酞酸及其鹽類；單過駄 201006503 =及其_和_ ;抗壞錢硬崎自旨；祕基肌胺 酸，烷基硫酸鹽；二辛基硫琥珀酸二 才=(domiphen b腿ide);地莫匹醇(仏_〇1); 辛底醇及其他㈣基触物； 以及任何上述的齡物。 ㈣I， 1.13任何上述組成物進一步包含一美白劑。1.5 Any of the above compositions comprises a basic amino acid of a salt type. 1.6 Any of the above compositions comprises arginine phosphate. 1.7 Any of the above compositions comprises a arginine hydrochloride. 1.8 Any of the above compositions comprises arginine sulfate. 1.9 Any of the above compositions comprises arginine hydrogencarbonate. 1.10 Any of the above compositions wherein the bioerodible polymer is selected from the group consisting of poly(lactic acid), poly(glycolic acid) and copolymers; polydioxanone, poly(ethyl oleate), poly(hydroxybutyrate) ), poly(hydroxyvalerate) and copolymer; polycaprolactone, polyanhydride, poly(orthoester), poly(iminocarbonate), polyester decylamine, polyesteramine, polycyanide Acrylates, polyphosphazenes, copolymers and other aliphatic polyesters, or suitable copolymers thereof, include copolymers of poly-L-lactic acid and poly-ε-caprolactone, fibrin (fibrin) ), collagen, glycosaminoglycan, sugar, polysaccharide, chondroitin, chitosan, alginate, faring, fibrinogen, cellulose, starch, glucoside Sugar, dextrin, hyaluronic acid, heparin, elastin; multi-block copolymers such as basal units constructed from glycolide, 5 201006503, S, ε-caprolactone; and polyethylene glycol and poly(ester or similar) ''based on leucine, phenylalanine and/or quercetin' - or a plurality of diols and one or more dicarboxylic acids. 1 '11 Any of the following compositions further comprising a gasification orphan present in the pores, for example selected from the group consisting of stannous fluoride, sodium fluoride, fluorination Unloading, sodium sulphate monosodium sulphate, ammonium fluoromonate, fluorinated amine, fluorinated money, and combinations thereof. 1.12 任 = hereinafter, the composition further comprises an antibacterial agent selected from the group consisting of trigassal; herbal extracts and Essential oils (eg rosemary extract, tea tree extract, magnolia extract, eugenol, menthol, eucalyptol, geraniol, carvacrol, citral, camphorol, catechol, methyl salicylic acid Epigall〇catechin gaiiate, epigallocatechin, gallic acid, jasmine extract, sea-buckthorn extract, propolis; A bismuth antibacterial agent (such as chlorhexidine, alexidine or octenidine); a quaternary ammonium compound (such as gasification, thiopurine (CPC), benzyl chloride , tetradecyl pyridyl chloride (TpC), gasified N-tetradecyl-4-ethylpyridine (TDEPC)); phenol Bacterial agent; hexetidine; otetidine bite; blood root test; excellent moth; delmopinol; salifluor; metal ions (such as zinc salts such as zinc sulphate, stannous salt, copper Salt, iron salt); sanguinarine; propolis and oxidizing agent (such as hydrogen peroxide, buffered sodium peroxyborate or sodium percarbonate); tannic acid and its salts; single pass 201006503 = and its _ and _; anti-bad money hard Qi Zizhi; secret base sarcosine, alkyl sulfate; dioctyl succinic acid two only = (domiphen b leg ide); delmopinol (仏 _ 〇 1); octyl alcohol and other (four) based contacts; and any of the above-mentioned ages. (d) I, 1.13 Any of the above compositions further comprises a whitening agent.
U4任何上述組成物進一步包含選自由過氧化物、金屬亞 氯酸鹽、過硼酸鹽、過碳酸鹽、過氧酸、次氣酸鹽及 其組合所構成群組之具有美白活性的美白劑。| .15任何上述組成物進一步包含過氧化氫或過氧化氣源例 如過氧化尿素或過氧化物鹽或複合物（舉例如過氧化 磷酸鹽、過氧化碳酸鹽、過硼酸鹽、過氧化矽酸醆戈 過硫酸鹽；例如過氧化填酸約、過硼酸納、過氧化妒 酸鈉、過氧化磷酸鈉和過硫酸鉀），或過氧化氫高分子 複合物例如過氧化氫_聚乙烯*7比洛咬_高分子複合物U4 Any of the above compositions further comprises a whitening active whitening agent selected from the group consisting of peroxides, metal chlorites, perborates, percarbonates, peroxyacids, hypoxides, and combinations thereof. Any of the above compositions further comprises hydrogen peroxide or a source of peroxygen gas such as urea peroxide or a peroxide salt or a complex (for example, peroxyphosphate, peroxycarbonate, perborate, peroxydecanoic acid)醆 过 persulfate; for example, peroxyacid acid, sodium perborate, sodium perrhenate, sodium persulfate and potassium persulfate), or hydrogen peroxide polymer complex such as hydrogen peroxide _ polyethylene * 7 Bilo bite_polymer complex
在另一具體實施例中’本發明包括組成物2.0，一種包 含多孔支架和存在於該孔内之鹼性胺基酸的組成物。 本發明亦包括下列的組成物： 2.1組成物2.0其中該鹼性胺基酸係精胺酸、離胺酸、瓜胺 酸、鳥胺酸、肌酸、組胺酸、二胺基丁酸、二胺基内 酸，其鹽類及/或其組合。 2.2組成物2.0或2.1其中該鹼性胺基酸具有L-構型。 2.3任一組成物2.0-2.2其中該鹼性胺基酸係精胺酸。 7 201006503 2.4任一組成物2.3 2.5任一組成物2.〇< 4 2.6任一組成物2.〇、2$ 2.7任一組成物2.〇、2 6 2.8任一組成物2.^ 2.9任一組成物2.8 2.10任一組成物2.〇、2 & 孔内。 其中該驗性胺基酸係L-精胺酸。 包含鹽型的鹼性胺基酸。 包含精胺酸磷酸鹽。 包含精胺酸鹽酸鹽。 包含精胺酸硫酸鹽。 包含精胺酸碳酸氫鹽。 其中該鹼性胺基酸可逆地存在於該 組成物2.〇、^9 乙烯、聚甲基中該支架係一塑膠’其係選自聚 酸醋、聚丙、广甲赌、聚胺基曱酸醋、聚乙稀對 Θ 2.11 任 苯二甲酸酯 膠和生物可降解塑髁、聚苯乙烯、聚醯胺類、生物塑 2.12任一組成物2.μ 物。 其中該支架係一生物可蝕性聚合 2.13任一組成物2.〇、2^ 50%重量比的峰性 其中该組成物包含從約1%至約 2.14任-組成物1.〇、2 =酸。 化鹽，例如選自氣化進一步包含存在於孔隙内的的氟 酸鈉、氟矽酸鈉、&亞錫、氟化鈉、氟化鉀、單氟磷 組合。 ^夕酸錢、氣化胺、氟化敍，及其 2.15任一組成物l.〇、2 W 氣沙；草本萃取物和步包含抗菌劑，其係選自三 取物、木蘭萃取物、瑞如香萃取物、茶樹萃 醇、香芹酚、檸檬醛、檜未醇^ ^膏案 知、兒茶酚、甲基水楊酸、 201006503 表沒食子兒茶素沒食子酸酯、表沒食子兒茶素、沒食 子酸、碧桃茉莉萃取物、沙棘萃取物、蜂膠）；雙脈抗 菌劑(例如沙威隆、阿立西定或奥替尼啶）；季錢化合物 (例如氯化鯨蠟基吡啶(CPC)、氯化苄烷銨、氯化十四 烷基吡啶（TPC)、氯化N-十四烷基-4-乙基吼咬 (TDEPC));苯酚殺菌劑；海克西定；奥替尼咬；血根 鹼；優碘；地莫匹醇；salifluor;金屬離子(例如鋅鹽如 〇 檸檬酸鋅、亞錫鹽、銅鹽、鐵鹽）；血根鹼；蜂膠和氧 化劑(例如過氧化氫、緩衝過氧硼酸鈉或過氧碳酸鈉）； 駄酸及其鹽類；單過酞酸及其鹽類和酯類；抗壞血酸 硬脂酸酯；油醯基肌胺酸；烷基硫酸鹽；二辛基硫破 ί白酸鹽；柳酸苯胺；漠化杜每芬；地莫匹醇；‘:醇° 及其他哌啶基衍生物；菸鹼酸製劑；亞氣酸鹽；以及 任何上述的混合物。 2.16任何上述組成物包含一美白劑。 ❹ 2.17任何上述組成物包含選自由過氧化物、金屬亞氯酸 鹽、過硼酸鹽、過碳酸鹽、過氧酸、次氣酸鹽及其組 合所構成群組之具有美白活性的美白劑。 ' 2.18任何上述組成物進一步包含過氧化氫或過氧化氫源例 如過氧化尿素或過氧化物鹽或複合物（舉例如過氧化 磷酸鹽、過氧化碳酸鹽、過硼酸鹽、過氧化矽酸鹽或 過硫酸鹽；例如過氧化磷酸鈣、過硼酸鈉、過氧化碳 酸鈉、過氧化磷酸鈉和過硫酸鉀），或過氧化氫高分子 複合物例如過氧化氫_聚乙烯σ比咯啶酮高分子複合物。 9 201006503 2.19可有效應用於口腔例如利用任何裝置3騎8之口腔 裝置的任何上述組成物，其可(i)減少❹卩舳牙的形 成；⑼減少、修補或抑制早期琺瑯質病變，例 由定量光激發螢光(QLF)或電齲齒測量法(ecm)的測 定，（111)減少或抑制牙齒的去礦化及促進再礦化 減少牙齒過敏性；（V)減少或抑制齒齦炎；（vi)促進L 腔内潰癌或傷口騎合；（vii)降低產_的濃 增加精胺酸溶解菌的相對濃度；⑽抑制口腔又’， 物生物膜的形成；（X)吃糖食之後上升及/ ΡΗ在至少ρΗ5.5的程度：⑽減少牙垢的積聚 治療、緩和或減少口腔乾燥；_)清潔牙齒和口腔. ㈣減少腐使牙齒變白；㈣牙齒對致鶴菌 免疫；及/或(xvii)促進包括心血管的身_康，例如 藉由降低經由口腔組織全身性感染的可能性。 2.2〇 -種藉她合說日胳任何上敝成物巾的成 或得到的組成物。 又传 本發明進-步提供-難置(裝置3 Q)，其係 -材料的口腔器具’該第-材料係以任_組成物弟 塗佈例如任一下列裝置： · δ 3.1裝置3.G其中該器具係-種頭部具有附著 3.2裝置3Λ其中組成物叫.19中之一種塗佈於 3.3裝置U或3.2其中紙成物aw中之一種^=該 頭部。 Λ 201006503 3.4裝置3.0其中該器具係一種牙籤。 3.5裝置3.0其中該器具係一種舌苔清潔器（tongue cleaner) ° 3.6裝置3.5其中該舌苔清潔器包含清潔舌頭的表面，該表 面以組成物1.0-2.19中之一種塗佈。 3.7裝置3.5其中該器具係一種護口膠。 3.8裝置3·0或3.7其中該器具係一種牙齒矯正裝置例如固 ❹ 位器。 3.9任一裝置3.0-3.7其係藉由說明於下文中的方法4或方 法5所製成。 本發明亦涵蓋方法4,其係一種製造用於口腔内器具的 方法包括： 1. 將生物可#性聚合物或其單體溶解於溶劑内以形成一 溶液； 2. 將鹼性胺基酸混合入該溶液内； ❿ 3.從該溶液取出該器具而使該溶液塗佈於器具上；以及 4.蒸發掉該溶劑。 該器具較佳為不可溶或實質上不溶解於該溶劑。 本發明亦涵蓋方法5,其係一種製造用於口腔内器具的 方法包括： 1. 將鹼性胺基酸與一單體掺合，該單體為可聚合以形成生 物可姓性聚合物； 2. 將器具浸泡入該混合物内； 201006503 3. 從混合物内取出該器具；以及 4. 在可誘發單體聚合反應的條件下處理該清潔器具以形 成生物可蝕性聚合物。 本發明進一步提供一種方法(方法6)，該方法包括使有 需要的人湘含有㈣胺基酸之口腔裝❹】如任一裝置 3.0-3.9而可達到(i)減少或抑制姓牙的形成；⑼減少、修 補或抑制早期_質病變，例如藉由定量光激發螢光(QLF) 或電麵齒測量法(ECM)的測定；⑽減少或抑制牙齒的去❹ 礦化及促進再礦化；（iv)減少牙齒過敏性；（v)減少或抑制 齒齦炎；（vi)促進口腔内潰瘍或傷口的癒合；（vU)降低產 酸菌的濃度；（Viii)增加精胺酸溶解菌的相對濃度；⑽抑 制口腔内微生物生物膜的形成：⑻吃糖食之後上升及/或 維持牙垢pH在至少pH 5.5的程度；⑽減少牙垢的積聚； (xii)治療、緩和或減少口腔乾燥；（xm)清潔牙齒和口腔； (xiv)減少腐蝕；（xv)使牙齒變白；（xvi)牙齒對致齲菌免 疫；及/或(xvii)促進包括心血管的身體健康，例如藉由降❹ 低經由口腔組織全身性感染的可能性。 本發明進一步包括鹼性胺基酸於製造牙齒裝置例如上 文中所述任一裝置3.0-3.9、例如於上文中所述製造方法例 如方法4或5 ’或於上文中所述方法例如方法6的用途。 本發明的其他具體實施例對於本技術領域中具有通常 知識者將是明顯的。 12 201006503 【實施方式】 如此處所述 一生物可蝕性聚合物係一種藉由暴 口腔之後可被降解的聚合物。當該材料與口腔内的= 如淫液接觸時可導致降解。聚合物與σ腔之間的磨 激亦可導致降解。視聚合物的厚度，僅與口腔 物表面被降解。 J取口In another embodiment, the invention comprises a composition 2.0, a composition comprising a porous scaffold and a basic amino acid present in the pore. The present invention also includes the following compositions: 2.1 Composition 2.0 wherein the basic amino acid is arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutyric acid, Diaminolacetic acid, salts thereof and/or combinations thereof. 2.2 Composition 2.0 or 2.1 wherein the basic amino acid has the L-configuration. 2.3 Any of the compositions 2.0-2.2 wherein the basic amino acid is arginine. 7 201006503 2.4 Any composition 2.3 2.5 Any composition 2. 〇 < 4 2.6 Any composition 2. 〇, 2$ 2.7 Any composition 2. 〇, 2 6 2.8 Any composition 2. 2.9 Any composition 2.8 2.10 any composition 2. 〇, 2 & Wherein the test amine acid is L-arginine. A basic amino acid containing a salt form. Contains arginine phosphate. Contains arginine hydrochloride. Contains arginine sulfate. Contains arginine bicarbonate. Wherein the basic amino acid is reversibly present in the composition 2. 〇, ^9 ethylene, polymethyl, the scaffold is a plastic selected from the group consisting of polyacid vinegar, polypropylene, gambling, polyamine hydrazine Sour vinegar, polyethylene bismuth 2.11 phthalate gel and biodegradable plastic enamel, polystyrene, polyamide, bioplastic 2.12 any composition 2.μ. Wherein the scaffold is a bioerodible polymerization 2.13 of any composition 2. 〇, 2 ^ 50% by weight of the peak property wherein the composition comprises from about 1% to about 2.14 of any composition 1. 〇, 2 = acid. The salt, for example selected from the group consisting of sodium fluorofluoride, sodium fluorophthalate, & stannous, sodium fluoride, potassium fluoride, monofluorophosphate, is present in the pores.夕酸钱, aerochemical amine, fluorinated, and any composition of 2.15, 〇, 2 W air sand; herbal extracts and steps comprising an antibacterial agent selected from the group consisting of three extracts, magnolia extract, Rui Ruxiang extract, tea tree extract alcohol, carvacrol, citral, decyl alcohol ^ ^ paste case, catechol, methyl salicylic acid, 201006503 epigallocatechin gallate, Epigallocatechin, gallic acid, jasmine extract, sea buckthorn extract, propolis); double-pulse antibacterial agents (eg, saviron, alistidine or octenidine); For example, cetylpyridinium chloride (CPC), benzalkonium chloride, tetradecylpyridinium chloride (TPC), N-tetradecyl-4-ethylphthalate (TDEPC), phenol sterilization Agent; hexetidine; otinib bite; blood base; iodine; delmopinol; salifluor; metal ions (such as zinc salts such as zinc citrate, stannous, copper, iron); Root base; propolis and oxidant (such as hydrogen peroxide, buffered sodium peroxyborate or sodium percarbonate); citric acid and its salts; monoperic acid and its salts and esters; ascorbic acid Acid ester; oil sulfhydryl creatinine; alkyl sulphate; dioctyl sulphate; sulphate arsenic; desertified dufenol; delmopinol; ': alcohol ° and other piperidinyl derivatives a nicotinic acid preparation; a sulfite acid salt; and a mixture of any of the foregoing. 2.16 Any of the above compositions comprises a whitening agent. ❹ 2.17 Any of the above compositions comprises a whitening active whitening agent selected from the group consisting of peroxides, metal chlorites, perborates, percarbonates, peroxyacids, hypoxides, and combinations thereof. ' 2.18 Any of the above compositions further comprises hydrogen peroxide or a source of hydrogen peroxide such as urea peroxide or a peroxide salt or complex (for example, peroxyphosphate, peroxycarbonate, perborate, peroxydecanoate) Or persulfate; for example, calcium phosphate peroxide, sodium perborate, sodium percarbonate, sodium peroxyphosphate and potassium persulfate), or a hydrogen peroxide polymer complex such as hydrogen peroxide _polyethylene σ pyrrolidone Polymer complex. 9 201006503 2.19 can be effectively applied to any of the above-mentioned compositions of the oral cavity, such as the oral device of any device 3, which can (i) reduce the formation of cavities; (9) reduce, repair or inhibit early enamel lesions, Determination of photoexcited fluorescence (QLF) or electrocautery measurement (ecm), (111) reducing or inhibiting demineralization of teeth and promoting remineralization to reduce tooth hypersensitivity; (V) reducing or inhibiting gingivitis; Promote L-cavity ulceration or wound riding; (vii) reduce the relative concentration of arginine-dissolving bacteria; (10) inhibit oral cavity, and biofilm formation; (X) rise after eating confectionery And / ΡΗ at a level of at least ρ Η 5.5: (10) reduce the accumulation of tartar treatment, ease or reduce dry mouth; _) clean teeth and mouth. (d) reduce rot to whiten teeth; (d) teeth immune to the bacterium; and / or (xvii) Promote the inclusion of cardiovascular disease, for example by reducing the likelihood of systemic infection through the oral tissue. 2.2〇 - The species that is obtained or obtained by any of the above-mentioned objects. Further, the present invention further provides that it is difficult to provide (device 3 Q), the system-material oral device 'the first material is coated with any of the following devices: · δ 3.1 device 3. Wherein the device is a head having an attachment 3.2 device 3, wherein one of the compositions is a coating of 13. device U or 3.2 of the paper product aw. Λ 201006503 3.4 Device 3.0 wherein the device is a toothpick. 3.5 Apparatus 3.0 wherein the apparatus is a tongue cleaner ° 3.6 apparatus 3.5 wherein the tongue cleaner comprises a surface for cleaning the tongue, the surface being coated with one of the compositions 1.0-2.19. 3.7 Device 3.5 wherein the device is a mouthguard. 3.8 Apparatus 3·0 or 3.7 wherein the apparatus is an orthodontic device such as a solid positioner. 3.9 Any of the devices 3.0-3.7 is made by the method 4 or method 5 described below. The invention also encompasses the method 4, which is a method for manufacturing an oral device comprising: 1. dissolving a bio-polymer or a monomer thereof in a solvent to form a solution; 2. using a basic amino acid Mixing into the solution; ❿ 3. removing the device from the solution to apply the solution to the device; and 4. evaporating the solvent. The device is preferably insoluble or substantially insoluble in the solvent. The invention also encompasses method 5, which is a method of making an oral device comprising: 1. blending a basic amino acid with a monomer that is polymerizable to form a biodegradable polymer; 2. Soak the device into the mixture; 201006503 3. Remove the device from the mixture; and 4. Treat the cleaning device under conditions that induce monomer polymerization to form a bioerodible polymer. The present invention further provides a method (method 6) which comprises causing a person in need thereof to contain an oral composition of (tetra) amino acid, such as any device 3.0-3.9, which can achieve (i) reduce or inhibit the formation of a tooth (9) reducing, repairing, or inhibiting early stromal lesions, such as by quantitative photoexcited fluorescence (QLF) or electrical surfacetooth measurement (ECM); (10) reducing or inhibiting demineralization of teeth and promoting remineralization (iv) reduce tooth hypersensitivity; (v) reduce or inhibit gingivitis; (vi) promote oral ulcer or wound healing; (vU) reduce acid-producing bacteria concentration; (Viii) increase arginine-dissolving bacteria Relative concentration; (10) inhibiting the formation of microbial biofilm in the oral cavity: (8) increasing and/or maintaining the tartar pH at a pH of at least 5.5 after eating the confection; (10) reducing the accumulation of tartar; (xii) treating, alleviating or reducing the dryness of the mouth; Xm) cleans teeth and mouth; (xiv) reduces corrosion; (xv) whitens teeth; (xvi) teeth are immune to cariogenic bacteria; and/or (xvii) promotes cardiovascular health, for example by hail Low likelihood of systemic infection through the oral tissue. The invention further comprises a basic amino acid for the manufacture of a dental device such as any of the devices 3.0-3.9 described above, such as the manufacturing method described above, such as method 4 or 5' or the method described above, such as method 6. use. Other embodiments of the invention will be apparent to those of ordinary skill in the art. 12 201006503 [Embodiment] A bioerodible polymer as described herein is a polymer which can be degraded by violent mouth. Degradation can occur when the material comes into contact with the oral cavity = for example. The friction between the polymer and the σ cavity can also cause degradation. Depending on the thickness of the polymer, it is only degraded with the surface of the oral cavity. J take the mouth
、-”有效量，，係足以在口腔内產生所欲治療或預防效應 而不造成例如刺激或過敏反應之不良副作用的數量。… 除非另有明示’否則此處所述驗性胺基酸包 離驗或鹽類之驗性胺基酸。 / 用於口腔的器具已為本技術領域中所習知，以及包括 例如牙刷、到舌器、牙線、牙籤、護口膠，以及牙齒^正 裝置例如牙套和is位ϋ。用於口助的器具並不僅偈限於 清潔和牙賴正裝置。其他器具包括可被用於口腔内之設 計的物件，例如奶嘴（亦稱為安慰器或纾緩器），以及幼兒和 嬰兒的㈣玩具例如咬牙環。其他器具包括非設計用於口 腔但人類可能將該物件含於口中的物件，例如筆和鉛筆。 此類器具雖然可用鹼性胺基酸處理例如表面塗;，但 較佳為直接將鹼性胺基酸併入該器具内以避免需重複地處 理。此可藉由以包含鹼性胺基酸的生物可蝕性聚合物塗佈 該器具而完成，或以相同方法製造該器具。由於聚合物的 表面係暴露細㈣，可將聚合物表面祕性胺基酸 釋放至口腔内。由於聚合物表面在例如正常用於口腔内時 被腐蝕，因此需供應釋入口腔内的額外鹼性胺基酸。 13 201006503 亦可使用多孔材料而直接將鹼性胺基酸併入該器具 内。該器具可自多孔材料製造，或可被其塗佈。通常，^ 材料含存在鹼性胺基酸於其中的孔隙。胺基酸可在使用該 器具例如置於口腔内時被釋出。若孔隙釋出其所含之胺基 酸，則該多孔材料可藉由暴露該鹼性胺基酸來處理以再充 填該孔隙。因此，該鹼性胺基酸可從該孔隙被釋出或駐留 其内。 用於製造使用於口腔内之器具的方法以及製造其之組 成物亦為本技術領域中所熟知的。本發明亦預期以包含生◎ 物可蝕性聚合物及鹼性胺基酸的組成物製造此類器具，或 具有鹼性胺基酸的多孔支架。 生物可蚀性聚合物已為本技術領域中具有通常知識者 所熟知，以及包括聚(乳酸）、聚（乙醇酸)和共聚物；聚二〇号 酮、聚（麵胺酸乙酯）、聚（經基丁酸酯）、聚（經基戊酸酯）和 共聚物；聚己内酯、聚酸酐、聚(原酸酯）、聚（亞胺基碳酸 酯）、聚酯醯胺類、聚酯胺類、聚氰丙烯酸酯類、聚磷腈類， 共聚物及其他脂族聚酯，或其適當共聚物包括聚-L-乳酸和 聚ε -己内酯的共聚物；混合物、共聚物，及其組合。其他 有用聚合物亦包括聚丙烯酸酯類、聚丙歸酸曱酯類、聚胺 基曱酸酯類、聚烯烴類、聚齒化乙烯類、聚齒化亞乙烯類、 聚乙烯醚類、芳香聚乙烯類、聚丙烯腈類、樹脂、聚矽氧 烷類、環氧樹脂和聚四氟乙烯。其他有用聚合物包括或基 於血纖維蛋白、膠原蛋白、葡萄胺聚醣 (glycosoaminoglycan)、寡酷和多醣、敕骨素、填酯質、石粦 14 201006503 酸膽鹼、聚葡萄胺糖、褐藻酸酯、纖維蛋白(fibring)、纖維 蛋白原、纖維素、殿粉、葡聚糖、糊精、玻尿酸、肝素和 彈性蛋白。該聚合物亦可為一多嵌段共聚物例如建構自乙 交酯、丙交酯、6 -己内酯和聚乙二醇的基礎單位。有用的 聚合物亦包括聚（酯-醯胺）聚合物或類似物，其以白胺酸、 苯丙胺酸及/或精胺酸為基礎’選擇地具有一或多種二元醇 類和一或多種二曱酸類。 ❻ 例如從單體形成此類聚合物的方法已為本技術領域中 所熟知。誘發聚合的方法已為本技術領域中所習知，例如 溶解於溶劑内、暴露於包括可見和UV輻射之輻射，以及 熱處理。 多孔支架為本技術領域中所習知，以及包括塑膠、陶 究和其他材料。塑膠及其形成為本技術領域中所熟知，以 及包括聚乙烯、聚曱基丙烯酸甲酯、聚胺基曱酸酯、聚乙 烯對苯二甲酸酯、聚丙烯、聚苯乙烯、聚醯胺、生物塑膠 Ο 和生物可降解塑膠。孔隙的大小極為重要其原因為小孔隙 度無法吸收和釋出該鹼性胺基酸，以及大孔隙將需持續的 負载。在本發明的一個具體實施例中，該孔隙的直徑平均 為從約10微米至約500微米例如約1〇微米、20微米、3〇 微米、40微米、50微米、60微米、70微米、80微米、9〇 微米、100微米、2〇〇微米、300微米或400微米直徑。 可被用於本發明組成物内的鹼性胺基酸不僅包括天然 驗性胺基酸例如精胺酸、離胺酸和組胺酸亦包括分子内具 有翹基和胺基的任何鹼性胺基酸。因此’鹼性胺基酸包括 15 201006503 但不侷限於精胺酸、離胺酸、瓜胺酸、鳥胺酸、肌酸、組 胺酸、二胺基丁酸、二胺基丙酸，其鹽類或其組合。在一 特定具體實施例中，該鹼性胺基酸係選自精胺酸、瓜胺酸 和鳥胺酸，較佳為精胺酸例如L-精胺酸。- "effective amount," is an amount sufficient to produce the desired therapeutic or prophylactic effect in the oral cavity without causing adverse side effects such as irritation or allergic reactions.... Unless otherwise stated, otherwise the aristomic acid pack described herein Tests or salts of test amines. / Appliances for the oral cavity are well known in the art and include, for example, toothbrushes, tongues, floss, toothpicks, mouthguards, and teeth. Devices such as braces and iss. Devices for mouth assistance are not limited to cleaning and squeezing devices. Other devices include items that can be used in the design of the mouth, such as pacifiers (also known as placebos or relief). (4), as well as toys for infants and babies such as teething. Other appliances include items that are not designed for the mouth but that humans may include in the mouth, such as pens and pencils. These devices can be treated with basic amino acids. For example, surface coating; however, it is preferred to incorporate the basic amino acid directly into the device to avoid repeated treatment. This can be by coating the device with a bioerodible polymer comprising a basic amino acid. Finishing, or manufacturing the device in the same way. Since the surface of the polymer is exposed to fine (d), the polymer surface amino acid can be released into the oral cavity. Since the polymer surface is corroded, for example, when used normally in the oral cavity, It is therefore necessary to supply an additional basic amino acid in the release chamber. 13 201006503 A basic amino acid can also be directly incorporated into the device using a porous material. The device can be manufactured from or can be coated with a porous material. Typically, the material contains pores in which the basic amino acid is present. The amino acid can be released when the device is placed, for example, in the oral cavity. If the pores release the amino acid contained therein, the porous The material may be treated by exposing the basic amino acid to refill the pores. Thus, the basic amino acid may be released or resident from the pores. Method for making an appliance for use in the oral cavity And the compositions from which they are made are also well known in the art. The present invention also contemplates the manufacture of such devices with a composition comprising a bioerodible polymer and a basic amino acid, or a basic amine group. Acid porous Bioerodible polymers are well known to those of ordinary skill in the art, and include poly(lactic acid), poly(glycolic acid) and copolymers; polydimethyl ketones, poly(ethyl face) ), poly(pyridinate), poly(pivalate) and copolymer; polycaprolactone, polyanhydride, poly(orthoester), poly(iminocarbonate), polyester oxime Amines, polyesteramines, polycyanoacrylates, polyphosphazenes, copolymers and other aliphatic polyesters, or suitable copolymers thereof, include copolymers of poly-L-lactic acid and poly-ε-caprolactone; Mixtures, copolymers, and combinations thereof. Other useful polymers also include polyacrylates, polyacrylic acid esters, polyamine phthalates, polyolefins, polydentate vinyls, polydentate vinylenes. Classes, polyvinyl ethers, aromatic polyethylenes, polyacrylonitriles, resins, polyoxyalkylenes, epoxies and polytetrafluoroethylene. Other useful polymers include or based on fibrin, collagen, glucosamine Glycos (glycosoaminoglycan), oligosaccharides and polysaccharides, scutellaria, sulphate, sarcophagus 1 4 201006503 Acid choline, polyglucosamine, alginate, fibring, fibrinogen, cellulose, house powder, dextran, dextrin, hyaluronic acid, heparin and elastin. The polymer may also be a multi-block copolymer such as a base unit constructed from glycolide, lactide, 6-caprolactone, and polyethylene glycol. Useful polymers also include poly(ester-guanamine) polymers or analogs which, based on leucine, phenylalanine and/or arginine, selectively have one or more glycols and one or more Diterpenic acid.方法 Methods for forming such polymers from monomers, for example, are well known in the art. Methods of inducing polymerization are well known in the art, such as dissolution in a solvent, exposure to radiation including visible and UV radiation, and heat treatment. Porous scaffolds are well known in the art and include plastics, ceramics, and other materials. Plastics and their formation are well known in the art and include polyethylene, polymethyl methacrylate, polyamino phthalate, polyethylene terephthalate, polypropylene, polystyrene, polydecylamine. , bioplastics and biodegradable plastics. The size of the pores is extremely important because small pores cannot absorb and release the basic amino acids, and large pores will require a constant load. In a particular embodiment of the invention, the pores have an average diameter of from about 10 microns to about 500 microns, such as about 1 inch, 20 microns, 3 microns, 40 microns, 50 microns, 60 microns, 70 microns, 80. Micron, 9 〇 micron, 100 micron, 2 〇〇 micron, 300 micron or 400 micron diameter. The basic amino acid which can be used in the composition of the present invention includes not only natural organic amines such as arginine, lysine and histamine but also any basic amine having a warp group and an amine group in the molecule. Base acid. Thus 'alkaline amino acid includes 15 201006503 but is not limited to arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutyric acid, diaminopropionic acid, Salt or a combination thereof. In a particular embodiment, the basic amino acid is selected from the group consisting of arginine, citrulline and ornithine, preferably arginine such as L-arginine.
鹼性胺基酸在其游離鹼或鹽型聚合之前或期間可被加 入該生物可蝕性聚合物。如此處所述，提及一鹼性胺基酸 時亦包括其鹽類。由於本發明的組成物和裝置擬被用於口 腔内，因此用於本發明之鹽類在提供的數量和濃度之下必 需對於該用途為安全。適當鹽類包括在提供的數量和濃度 之下通常被視為生理上可接受之醫藥上可接受鹽的技術中 習知鹽類。生理上可接受鹽包括衍自醫藥上可接受無機或 有機酸類或鹼類者，例如可形成生理上可接受陰離子之酸 的酸加成鹽類例如鹽酸鹽或溴化鹽，以及可形成生理上可 接受陽離子之鹼的鹼加成鹽，例如衍自鹼金屬如鉀和鈉或 鹼土金屬如鈣和鎂者。可利用本技術領域中已知的標準程 序獲侍生理上可接受鹽，例如藉由一足量鹼性化合物如胺 與可產生一生理上可接受陰離子的適當酸之反應。 、本發明組成物包含—有效量驗性胺基酸。因此，該 組成物可包含從約1%至約5G%重量比雜性胺基酸，例如 約 1、2、3、4、5、10、15、20、25、30、35、40 或 45%。 在-個具體實施例中，該驗性胺基酸可溶解於聚合物 内。在-較佳㈣實施例巾，紐性胺基酸不溶於該聚合 物内。若胺基酸為不可溶時，該胺基酸較佳為具有足夠小 的粒度而使其用於口㈣時不造成口腔的刺激。該胺基酸 201006503 較佳為均勻分佈於該聚合物内。 在一個具體實施例中該聚合物係一陰離子聚合物，例 如聚羧酸鹽聚合物如丙烯酸鹽聚合物或共聚物，其中兮驗 性胺基酸與聚合物内的羧酸基團形成鹽。 、^ 在本發明的一個具體實施例中’該生物可蝕性聚合物 或多孔支架選擇性地包含-有效量的氟化物或氟離子源。 本組成物内可使用廣泛不同的氟離子產生材料作為可溶性The basic amino acid can be added to the bioerodible polymer before or during its free base or salt type polymerization. As mentioned herein, reference to a basic amino acid also includes salts thereof. Since the compositions and devices of the present invention are intended to be used in the oral cavity, the salts used in the present invention must be safe for this use in the amounts and concentrations provided. Suitable salts include the well-known salts of the art which are generally considered to be physiologically acceptable pharmaceutically acceptable salts under the amounts and concentrations provided. Physiologically acceptable salts include those derived from pharmaceutically acceptable inorganic or organic acids or bases, such as acid addition salts such as hydrochlorides or bromides which form a physiologically acceptable anionic acid, and which form physiological Base addition salts of bases which accept cations, such as those derived from alkali metals such as potassium and sodium or alkaline earth metals such as calcium and magnesium. Physiologically acceptable salts can be obtained by standard procedures known in the art, for example by reaction of a sufficient amount of a basic compound such as an amine with a suitable acid which produces a physiologically acceptable anion. The composition of the invention comprises an effective amount of an amino acid. Thus, the composition may comprise from about 1% to about 5G% by weight of the fatty amino acid, for example about 1, 2, 3, 4, 5, 10, 15, 20, 25, 30, 35, 40 or 45 %. In a particular embodiment, the in situ amino acid is soluble in the polymer. In the preferred embodiment of the invention, the neotide acid is insoluble in the polymer. If the amino acid is insoluble, the amino acid preferably has a particle size small enough that it does not cause irritation to the mouth when it is applied to the mouth (iv). The amino acid 201006503 is preferably uniformly distributed within the polymer. In one embodiment the polymer is an anionic polymer, such as a polycarboxylate polymer such as an acrylate polymer or copolymer wherein the test amine acid forms a salt with a carboxylic acid group within the polymer. In a particular embodiment of the invention, the bioerodible polymer or porous scaffold selectively comprises an effective amount of a fluoride or fluoride ion source. A wide variety of fluoride ion-generating materials can be used as soluble in the composition.
氟化物源。適當氟離子產生材料的實例請參考授予Briner 等人的美國專利案號3，535，42丨；授予Parran，Jr.等人的美國 專利案號4,885,155錢授予Widder f人的美國專利案號 3,678，154，藉由引述將其併入於此。代表性氟離子源包括 但不侷限於氟化亞錫、氟化鈉、氟化鉀、單氟磷酸鈉、氟 矽酸鈉、氟矽酸銨、氟化胺、氟化銨，及其組合。在某些 具體實例中，該氟離子源包括氟化亞錫、氟化鈉、單氣^ 酸鈉，及其混合物。 在本發明的另一具體實施例中，該生物可触性聚合物 或多孔支架可選擇性地包含—防腐劑或抗微生物劑以進一 步增=性絲酸的有益效應，該防制或抗微生物係選 自二氯沙：草本萃取物和精油(例如迷迭香轉物、瑞香紛、 薄荷醇二桉葉醇、甲基水揚酸）；雙胍抗菌劑(例如沙威隆、 阿立西疋(alexidine)或奥替尼咬(〇cten^^ne));季錄化合物 (例如亂化録峨基处啶）；苯酚殺菌劑；海克西定 (heXetidine);優碘；地莫匹醇(dehnopinol) ; saliflU〇r :金屬 離子(例如辞鹽如檸檬酸鋅）；血根鹼(sanguinarine) ;蜂膠； 17 201006503 及其組合。 當塗佈於一器具上時，該生物聚合物或多孔支架較佳 為具有不妨礙該器具使用的足夠薄度，但具有使其後正常 使用之器具上例如使用3、4、5、1〇、ι5、2〇、25、3〇、6〇 或90次之後保留足夠量聚合物的厚度。該器具的正常使用 將視特定器具而定。該生物聚合物的厚度可從約〇丨微米至 約3000微米’約1微米、5微来' 1〇微米、％微米、％ 微米、100微米、250微米、500微米、1000微米、2〇〇〇微 米或約3000微米的厚度。塗佈層的厚度將視特定器具而定。© 本發明組成物亦可含有香料。可被用於本發明實務的 調味劑包括，但不侷限於精油和各種的調味醛類、酯類、 醇類，以及類似材料。精油的實例包括留蘭香油、薄荷油、 冬清油、黃樟油、丁香油、鼠尾草油、桉葉油、馬鬱蘭油、 肉桂油、檸檬油、萊姆精油、葡萄柚油和橙油。此類化學 物質亦可使用甲醇、香芹酮（carvone)和大茴香腦 (anethole)。本發明組成物亦含有著色劑。香料和著色劑的 用途為幫助測定該支架是否含該胺基酸，或生物可蝕性聚❹ 合物的被降解程度。 本發明組成物亦可被用作為口腔内的黏著劑，例如與 牙齒矯正牙套使用之牙套用黏著劑。本發明組成物亦可用 作為製造器具的勒著劑，例如黏著牙刷頭至其刷柄。本發 明亦可被用作為牙科用密封劑，例如保護塗料。 實例1 以包含40%重量比L_精胺酸和香料如薄荷的生物可蝕 201006503 性聚合物㈣適用於_性運㈣ ==:降解而“精胺酸釋八口腔:二= 修補或抑制早期鞋螂質病變；減 少或抑制^的去礦化及促進再魏；減少或抑制齒銀 炎；降低產酸_丨農度；增加精㈣溶解菌的相對濃度； 以及使牙垢PH上升及/或維持在至少pH $ 5的程度。重複 使用該護口料進-步降_聚合物，當動膠不再具有 薄荷味道時使用者可確認聚合物已被完全降解。 實例2 以具有50微米平均孔徑的多孔塑膠支架製造奶嘴。將 該奶嘴浸潰於包含精胺酸碳酸氫鹽的清潔溶液内，並且該 精胺酸碳酸氫鹽被吸收入孔内。 實例3Fluoride source. For an example of a suitable fluoride ion-generating material, reference is made to U.S. Patent No. 3,535,42, issued to the name of the entire disclosure of U.S. Pat. 154, which is incorporated herein by reference. Representative fluoride ion sources include, but are not limited to, stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluoroantimonate, ammonium fluoroantimonate, amine fluoride, ammonium fluoride, and combinations thereof. In some embodiments, the fluoride ion source comprises stannous fluoride, sodium fluoride, sodium monosodium sulfate, and mixtures thereof. In another embodiment of the invention, the biotactable polymer or porous scaffold may optionally comprise a preservative or antimicrobial agent to further enhance the beneficial effects of the sex silk, the control or antimicrobial It is selected from the group consisting of dichlorin: herbal extracts and essential oils (such as rosemary, scented menthol, menthol, and methyl salicylate); biguanide antibacterials (such as Shaweilong, Alixidin) (alexidine) or octenidine bite (〇cten^^ne)); seasonally recorded compounds (eg, pyridine); phenol bactericide; hexetidine; iodine; delmopinol (dehnopinol); saliflU〇r: metal ion (for example, salt such as zinc citrate); sanguinarine; propolis; 17 201006503 and combinations thereof. When applied to an implement, the biopolymer or porous scaffold preferably has a sufficient thickness that does not interfere with the use of the device, but has an apparatus for normal use thereafter, for example, 3, 4, 5, 1 . A sufficient amount of polymer is retained after ι 5, 2 〇, 25, 3 〇, 6 〇 or 90 times. The normal use of the appliance will depend on the particular appliance. The biopolymer may have a thickness of from about 〇丨 micron to about 3000 micron 'about 1 micron, 5 micro', 1 micron, % micron, % micron, 100 micron, 250 micron, 500 micron, 1000 micron, 2 〇〇. 〇 microns or a thickness of about 3000 microns. The thickness of the coating layer will depend on the particular appliance. © The composition of the present invention may also contain a fragrance. Flavoring agents that can be used in the practice of the present invention include, but are not limited to, essential oils and various flavoring aldehydes, esters, alcohols, and the like. Examples of essential oils include spearmint oil, peppermint oil, winter oil, sassafras oil, clove oil, sage oil, eucalyptus oil, marjoram oil, cinnamon oil, lemon oil, lime oil, grapefruit oil and orange oil. Methanol, carvone and anethole can also be used for such chemicals. The compositions of the present invention also contain a colorant. The use of perfumes and colorants is to aid in determining whether the scaffold contains the amino acid, or the degree of degradation of the bioerodible polyconjugate. The composition of the present invention can also be used as an adhesive in the oral cavity, for example, an adhesive for dental mouthpieces for use with orthodontic braces. The composition of the present invention can also be used as a tamper for the manufacture of articles, for example, by adhering the brush head to its handle. The invention can also be used as a dental sealant, such as a protective coating. Example 1 Biodegradable 201006503 polymer containing 40% by weight of L_arginine and perfume such as peppermint (4) is suitable for _sexual transport (4) ==: degradation and "arginine acid release eight oral: two = repair or inhibition Early shoe enamel lesions; reduce or inhibit demineralization and promote re-Wei; reduce or inhibit dental calculus; reduce acid production _ 丨 度 ;; increase the relative concentration of fine (4) lysing bacteria; and increase tartar PH and / Or maintain it to a level of at least pH 5. Repeat the use of the mouth-feeding-step-polymer, the user can confirm that the polymer has been completely degraded when the gelatin no longer has a mint taste. Example 2 has 50 microns A porous plastic stent having an average pore diameter produces a teat. The teat is immersed in a cleaning solution containing arginine hydrogencarbonate, and the arginine hydrogencarbonate is absorbed into the pores.
將實例2的奶嘴給予嬰兒正常使用，即吸和吮。當嬰 兒吸和吮該奶嘴時’精胺酸碳酸氳鹽被釋入口腔内而抑制 口腔内微生物生物膜的形成。 實例4 將實例3的經使用奶嘴浸潰入包含精胺酸碳酸氫鹽的 清潔溶液内。 實例5 以包含精胺酸及顏色如紅色的生物可姓性聚合物塗佈 透明牙刷頭。將鬃毛貼附至頭部，及使該頭部連接一把柄。 201006503 口腔内使用該牙刷時該聚合物可被降解而釋出精胺酸。當 該頭部不再呈紅色時使用者則得知需更換該頭部或牙刷。 【圖式簡單說明】 無 【主要元件符號說明】 無The nipple of Example 2 was given to the baby for normal use, i.e., sucking and rubbing. When the baby sucks and licks the nipple, the arginine strontium carbonate is released into the cavity to inhibit the formation of microbial biofilm in the oral cavity. Example 4 The used nipple of Example 3 was dipped into a cleaning solution containing arginine hydrogencarbonate. Example 5 A transparent toothbrush head was coated with a biodegradable polymer comprising arginine and a color such as red. Attach the bristles to the head and attach the head to a handle. 201006503 The polymer can be degraded to release arginine when the toothbrush is used in the mouth. When the head is no longer red, the user knows that the head or toothbrush needs to be replaced. [Simple diagram description] None [Main component symbol description] None
20 201006503 發明糞利說明書 98J920 201006503 Invention Manure Guide 98J9
(本說明書格式、順序，請勿任意更動，※記號部分請勿填寫） ※申請案號： ※申請曰： 分類： 、發明名矛冉.（中文/英文） 組成物及裝置（二） COMPOSITIONS AND DEVICES 二、中文發明摘要： 本發明提供包含鹼性胺基酸的口腔器具及製造此類11 具的組成物，以及製造和使用此類器具的方法。 ©三、英文發明摘要： The present invention provides oral instruments comprising a basic amino acid, to compositions for making such instruments, and to methods of making and using such instruments. 1 2〇1〇〇65〇3 七、申請專利範圍： • 一種含有游離或鹽型鹼性胺基酸之組成物，該鹼性胺 基酸係被後入生物可餘性聚合物。(Please do not change the format and order of this manual, please do not fill in the ※ part) ※Application number: ※Application曰: Classification: Invented name spear. (Chinese/English) Composition and device (2) COMPOSITIONS AND DEVICES II. Abstract of the Invention: The present invention provides an oral appliance comprising a basic amino acid and a composition for the manufacture of such an article, and a method of making and using such an appliance. ©3, English Abstract: The present invention provides oral instruments comprising a basic amino acid, to compositions for making such instruments, and to methods of making and using such instruments. 1 2〇1〇〇65〇3 VII. : A composition containing a free or salt-type basic amino acid which is incorporated into a biorenewable polymer.
2.如申請專利範圍第1項之組成物，其中該生物可蝕性 聚合物係選自聚(乳酸）、聚（乙醇酸)和共聚物；聚二啐 _、聚(麩胺酸乙酯）、聚(羥基丁酸酯）、聚(羥基戊酸酯) 和共聚物；聚己内酯、聚酸酐、聚(原酸酯）、聚(亞胺基 碳酸酯）、聚酯醯胺類、聚酯胺類、聚氰丙烯酸酯類、 聚磷腈類，共聚物及其他脂族聚酯，或其適當共聚物包 括聚-L-乳酸和聚ε-己内酯的共聚物、血纖維蛋白、膠 原蛋白、葡萄胺聚畴（glycosoaminoglycan)、寡醋、多 聽、軟骨素、聚葡萄胺糖（chitosan)、褐藻酸酯、纖維 蛋白（fibring)、纖維蛋白原、纖維素、澱粉、葡聚糖、 糊精、玻尿酸、肝素、彈性蛋白；多嵌段共聚物例如建 構自乙交酯、丙交酯、ε _己内酯的基礎單位；以及聚 乙一醇和聚（酯_醯胺)聚合物或類似物，其以白胺酸、笨 丙胺酸及/或精胺酸為基礎，選擇地具有一或多種二元醇 類和一或多種二甲酸類。 3 _ ’ 種組成物，其包括具有孔隙之支架及存在該孔隙間 之鹼性胺基酸。 4.如申請專利範圍第3項之組成物，其中該支架係塑膠。 申請專利範圍第3或4項之組成物，其中該支架係 選自聚乙烯、聚甲基丙烯酸曱酯、聚胺基甲酸酯、聚乙 21 201006503 烯對苯二甲酸酯、聚丙烯、聚苯乙烯、聚醯胺類、生物 塑膠、生物可降解塑膠，及其組合。 6. 如申請專利範圍第3〜5項中任一項之組成物，其中該 鹼性胺基酸可逆地存在於該孔隙間。 7. 如上述申請專利範圍中任一項之組成物，其中該鹼性 胺基酸係精胺酸、離胺酸、瓜胺酸、鳥胺酸、肌酸、 組胺酸、二胺基丁酸、二胺基丙酸，其鹽及/或其組 合。 8. 如上述申請專利範圍中任一項之組成物，其中該鹼性 胺基酸具有L-構型。 9. 如上述申請專利範圍中任一項之組成物，其中該鹼性 胺基酸係精胺酸。 10. 如上述申請專利範圍中任一項之組成物，其中該驗性 胺基酸係L-精胺酸。 11. 如上述申請專利範圍中任一項之組成物，其包含鹽型 的鹼性胺基酸。 12. 如上述申請專利範圍中任一項之組成物，其包含精胺 酸磷酸鹽。 13. 如上述申請專利範圍_任一項之組成物，其包含精胺 酸鹽酸鹽。 14. 如上述申請專利範圍中任一項之組成物，其包含一精 22 201006503 胺酸鹽及一陰離子聚合物。 15. 如上述申請專利範圍令任一項之組成物，其包含精胺 酸碳酸氫鹽。 16. 種裝置，其包括使用如申請專利範圍第1〜15項中 任一項之組成物塗佈之器具。 魯 ❿ 17. ^請專利範圍第16項之裝置，其中該器具係包括 具有鬃毛貼附其頭部的牙刷。 A ;=專2圍第17項之裝置，其中該鬃毛被如申 身專利範圍心七項中任―項之組成物塗佈。 19.如申請專利範圍帛17或18項 2〇如申請專利範圍第W項中任-項之組成物=破 h如中請專利範圍第16項之裝置，其_該器具係牙藏。 • ^申請專利範圍第16項之裝置 清潔器。 Τ Μ器具係舌苔 22. $申請專利範圍第21項之裝置，其中該 f 一清潔舌頭的表面，該表面係以如申二主專口二^包 1〜15項中任一項之組成物塗佈。申巧專利範圍第 3’如申請專利範圍第16項之 膠。 置其中該器具係護口 ‘如申請專利範圍第16項之裝置 。 場正裝置。 、中該器具係牙齒 23 201006503 > 、 25. —種方法，复可 修補或抑制早期二7或抑制姓牙的形成；⑼減少、 灿啦歧發勞光 牙齒的去魏及促進二J::，咸少抑制 f少(或=炎，促進-内潰牙:：:的:) ； (viii) —目對/辰度，⑻抑制口腔内微生物生物膜的形成 乙甜食之後上升及/或維持牙垢pH在至少pH 5 5的程 度；〇d)減少牙垢的積聚；（xii)治療、緩和或減少口腔 乾燥；（xiii)清潔牙齒和口腔；（xiv)減少腐蝕；（xv)使 牙齒變白；（xvi)使牙齒對致麵菌免疫；及/或(χνϋ)促進 包括心血管的身體健康，例如藉由降低經由口腔組織全 身性感染的可能性’其包含使用一 口腔裝置’該裝置包 含鹼性胺基酸，其係根據個人的需要。 26. 如申請專利範圍第 _/、，_ ,、 種鹼性胺基酸於製造牙齒裝置之用 如申請專利範圍第25項之方法，其中該裝置係一種 如申請專利範圍第16〜24項中任一項之裝置。 27. 途 T至慨*丨王妝麥Η又/八衣巧•菌衷置之用述'^ 28.如申請專利範圍第27項之用途，其中該裝置係 如申請專利範圍第16〜24項中任一項之裝置。 24 201006503 四、指定代表圖·· (一) 本案指定代表圖為：第（無）圖。 (二) 本代表圖之元件符號簡單說明： 無 五、本案若有化學式時，請揭示最能顯示發明特徵的化學式： 無2. The composition of claim 1, wherein the bioerodable polymer is selected from the group consisting of poly(lactic acid), poly(glycolic acid), and copolymer; polydioxane, poly(ethyl glutamate) ), poly(hydroxybutyrate), poly(hydroxyvalerate) and copolymer; polycaprolactone, polyanhydride, poly(orthoester), poly(iminocarbonate), polyester decylamine , polyesteramines, polycyanoacrylates, polyphosphazenes, copolymers and other aliphatic polyesters, or suitable copolymers thereof, including copolymers of poly-L-lactic acid and poly-ε-caprolactone, blood fibers Protein, collagen, glycosaminoglycan, vinegar, polysynthesis, chondroitin, chitosan, alginate, fibring, fibrinogen, cellulose, starch, Portuguese Glycan, dextrin, hyaluronic acid, heparin, elastin; multi-block copolymers such as basal units constructed from glycolide, lactide, ε-caprolactone; and polymerization of poly(ethylene glycol) and poly(ester amide) Or an analog based on leucine, albinoic acid and/or arginine, optionally having one or more Class and a diol or more dicarboxylic Acid. 3 _ ' Compositions comprising a scaffold having pores and a basic amino acid present between the pores. 4. The composition of claim 3, wherein the stent is a plastic. The composition of claim 3 or 4, wherein the support is selected from the group consisting of polyethylene, polymethyl methacrylate, polyurethane, polyethylene 21 201006503 olefin terephthalate, polypropylene, Polystyrene, polyamines, bioplastics, biodegradable plastics, and combinations thereof. 6. The composition of any one of claims 3 to 5, wherein the basic amino acid is reversibly present between the pores. 7. The composition according to any one of the preceding claims, wherein the basic amino acid is arginine, lysine, citrulline, ornithine, creatine, histidine, diamine Acid, diaminopropionic acid, salts thereof and/or combinations thereof. 8. The composition of any of the preceding claims, wherein the basic amino acid has an L-configuration. A composition according to any one of the preceding claims, wherein the basic amino acid is arginine. A composition according to any one of the preceding claims, wherein the testable amino acid is L-arginine. A composition according to any one of the preceding claims, which comprises a basic amino acid of a salt type. A composition according to any one of the preceding claims, which comprises arginine phosphate. 13. The composition of any one of the preceding claims, which comprises a arginine hydrochloride. 14. The composition of any of the preceding claims, comprising a fine 22 201006503 aminate and an anionic polymer. 15. A composition according to any of the preceding claims, which comprises arginine hydrogencarbonate. A device comprising an article coated with a composition according to any one of claims 1 to 15.鲁❿ 17. The device of claim 16 wherein the device comprises a toothbrush having a bristles attached to the head. A;=Special 2, the device of item 17, wherein the mane is coated with a composition of any of the seven items in the scope of the patent application. 19. If the scope of the patent application is 帛 17 or 18 2 〇 组成 组成 申请 申请 申请 = = = = = = 组成 组成 组成 组成 组成 组成 组成 组成 组成 组成 组成 组成 组成 如 如 如 如 如 如 如 如 如 如 如 如 如 如 如• ^Applicable to the device of the scope of the scope of the device cleaner. Τ Μ 系 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 Coating. Shen Qiao's patent scope is 3' as the glue of the 16th article of the patent application. Place the device as a protective device ‘as in the device of claim 16th. Field positive device. The device is a tooth 23 201006503 > , 25. A method that can repair or inhibit the formation of the early 2 or 7 or the formation of the last tooth; (9) reduce, the difference between the hair and the promotion of the tooth :, less salty inhibition f (or = inflammation, promotion - internal cavities::::); (viii) - eye / length, (8) inhibition of oral microbial biofilm formation after the rise of the sweets and / or Maintain tartar pH at least pH 5 5; 〇 d) reduce tartar accumulation; (xii) treat, alleviate or reduce dry mouth; (xiii) clean teeth and mouth; (xiv) reduce corrosion; (xv) change teeth (xvi) immunizing teeth against facets; and/or (χνϋ) promoting physical health including cardiovascular, for example by reducing the likelihood of systemic infection through the oral tissue 'which includes the use of an oral device' Contains a basic amino acid, depending on the individual's needs. 26. The method of claim _/, _, , a basic amino acid for use in the manufacture of a dental device, such as the method of claim 25, wherein the device is a patent application range 16 to 24 Any of the devices. 27. The way T to the generous * 丨 妆 妆 Η / / 八 八 八 八 八 菌 菌 菌 菌 ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ 28. 28. 28. 28. 28. 28. 28. 28. 28. 28. 28. 28. 28. 28. 28. 28. 28. 28. A device of any of the items. 24 201006503 IV. Designation of Representative Representatives (1) The representative representative of the case is: (No). (2) A brief description of the symbol of the representative figure: None 5. If there is a chemical formula in this case, please disclose the chemical formula that best shows the characteristics of the invention: None