200946123 九、發明說明： 【發明所屬之技術領域】 本發明係有關於一種中草藥組成物’特別是有關於 一種用以控制代謝症候群之中草藥組成物。 【先前技術】 ❹ ❹ 代謝症候群係指生理代謝層面的心血管危險因子的聚集現 象’這些危險因子主要包括高血壓（或血壓偏高但未達高血壓診斷 標準）、血脂異常（包含血中三酸甘油脂偏高、高密度脂蛋白膽固 醇偏低_質代謝異常）、糖尿病（或纽血糖偏高/g萄糖财受不 良）、肥胖(腹部肥胖）、以及高尿酸與凝金因子的不正常等。若未 能及時遏=代謝症候群，代謝症候群將很可能轉變為糖 尿病目月醫學界也已將糖尿病認定為代謝症候群持續 發展的必然結果。 代謝症候群的預防方法，除了多運動、注意飲食習 If、疋^健康檢查之外’罹病後的血糖監控也是相當重 ^的％目刖，已有許多控制血糖的方法被開發出， ，醫廣泛採用之方法：直接補充騰島素或是給 口服樂物來控制血糖，這些藥物包括雜尿素類、雙脈 类二：苦酶抑制劑等。它們的功能主要是藉由促進胰島 t 必、增加身體組織對於葡萄糖的敏感性，或是延 緩體内，水化合物的吸收來達到降血糖的目的亦或， 服用調節血糖之健康食品以控制人體血糖值。/ 200946123 但糖尿病的發生並非全是因為生活及飲食習慣不當 所造成，隨著人體老化，胰臟功能本來就會逐漸衰退， 最明顯的改變便是胰島素的分泌量開始降低，身體組織 利用葡萄糖的能力也愈來愈差（胰島素抗性增加），若未適 時調整自己的生活型態，便會罹患糖尿病。 正如上段所言，糖尿病的發生有可能是胰島素的 量」或「質」出現問題，但孰輕孰重則因人而異，這 •也說明為何不是每一種西藥或產品都能在病友身上產生 效應，因為有的病友需要增加胰島素分泌量，有的則應 從改善抗性著手，單一性質的產品並不能滿足所有病友 的需求，這是台灣目前現有產品所遭遇到的問題，也突 顯出開發多功能配方的重要性。 目刖’在台灣市場中’較具規模的調節企糖產品為 加特福GT&F奶粉或柄翰人蔘粉，雖然在安全性上明顯 ，於西藥’但根據其屬性(騰島素增敏顏）及健康食品的 ❹樂理實驗結果顯示，兩者除了作用緩慢外，效果也與西 樂有一段不小的差距。也因此造成病友陷人討厭西藥卻 不得不使用的窘境。 值得我們注意，目前市面上的降血糖產品，； ^或中藥’大多是以單—作㈣方式來控制血糖… 進胰島素分泌或是降低胰島素抗性 二 之一 ’功效上便會有缺憾，(例如：1 :島素分泌劑類產品雖然降血糖效果快，但僅是治標 也就是停藥後便立即無效；而增敏劑類產品，長期使） 200946123 下雖可以增加胰島素的品質，達到治本的效果，但短期 使用卻無明顯效果’可是，降低高血糖所帶來的危害對 病友而言卻是當務之急，所以，效果緩慢成了這類產品 致命的缺點。 有鑑於習知技藝之各項問題，為了能夠兼顧解決 之’本發明人基於多年研究開發與諸多實務經驗，提出 一種用以控制代謝症候群之中草藥組成物，其包含咸豐 草以及人蔘。咸豐草中的聚乙块類化合物具有促進騰島 素分泌的功效，人蔘中的皂苷則能夠改善胰島素抗性。 兩者經過適當比例結合後，將能發揮兩者的優點，達到 最佳的控制效果。 【發明内容】 有鑑於此，本發明之主要目的係提供一種中草藥組 成物，特別是有關於用以控制代謝症候群之中草藥組成 物。200946123 IX. DESCRIPTION OF THE INVENTION: TECHNICAL FIELD OF THE INVENTION The present invention relates to a Chinese herbal medicine composition, particularly to a herbal composition for controlling metabolic syndrome. [Prior Art] ❹ ❹ Metabolic syndrome refers to the aggregation of cardiovascular risk factors at the physiological metabolic level. These risk factors mainly include hypertension (or high blood pressure but not high blood pressure diagnostic criteria), dyslipidemia (including blood three) High acid glyceride, low-density lipoprotein cholesterol (abnormal metabolism), diabetes (or high blood sugar / poor glucose), obesity (abdominal obesity), and high uric acid and clotting factors Normal and so on. If the metabolic syndrome is not suppressed in time, metabolic syndrome will likely be converted to diabetes. The medical profession has also identified diabetes as the inevitable result of the continued development of metabolic syndrome. The prevention of metabolic syndrome, in addition to multi-exercise, pay attention to diet, If, 疋 ^ health check, 'glycemic monitoring after rickets is also a very heavy % of the eyes, there have been many methods to control blood sugar have been developed, widely The method used is: directly add temsanone or give oral music to control blood sugar, these drugs include miscellaneous urea, double veins 2: lipase inhibitors. Their function is mainly to promote the islet t, increase the sensitivity of body tissues to glucose, or delay the absorption of water compounds in the body to achieve the purpose of lowering blood sugar, or take healthy foods that regulate blood sugar to control human blood sugar. value. / 200946123 But the occurrence of diabetes is not caused by improper living and eating habits. As the body ages, the pancreas function will gradually decline. The most obvious change is that the secretion of insulin begins to decrease, and the body tissues use glucose. The ability is getting worse (increased insulin resistance), and if you don't adjust your lifestyle at the right time, you will get diabetes. As mentioned in the previous paragraph, the occurrence of diabetes may be caused by the amount of insulin or "quality", but the severity of the disease varies from person to person. This also explains why not every western medicine or product can have an effect on the patient. Because some patients need to increase the amount of insulin secretion, and some should start from improving resistance. A single product cannot meet the needs of all patients. This is a problem encountered in Taiwan's current products, and it also highlights the development of multifunctional functions. The importance of the formula. Seeing 'the Taiwanese market' is a relatively large-scale regulation of sugar products, such as Gatford GT & F milk powder or handle Han people powder, although it is obvious in safety, in Western medicine 'but according to its attributes (Tengdao Su Zeng The results of the experimental results of Min Yan and healthy foods show that apart from the slow effect, the effect is also quite different from that of Xi Le. It also caused the dilemma that the sick people were tempted to hate western medicine but had to use it. It is worthy of our attention that the current hypoglycemic products on the market, ^ or Chinese medicine 'mostly use single-made (four) way to control blood sugar... Into insulin secretion or reduce insulin resistance one of the two 'effects will have shortcomings, ( For example: 1: Although the anti-hyperglycemic effect of the island secreting agent product is fast, it is only effective after the treatment is stopped, and the sensitizer product can be used for a long time. The effect, but short-term use has no obvious effect' However, reducing the harm caused by high blood sugar is a top priority for patients, so the slow effect has become a fatal shortcoming of such products. In view of the problems of the prior art, in order to be able to solve the problem, the present inventors have proposed a herbal composition for controlling metabolic syndrome based on years of research and development and many practical experiences, including Xianfeng grass and human mites. The poly-b-block compounds in the salty grass have the effect of promoting the secretion of tensin, and the saponins in the human sputum can improve insulin resistance. After a proper combination of the two, the two will be able to take advantage of both to achieve the best control. SUMMARY OF THE INVENTION In view of the above, it is a primary object of the present invention to provide a herbal composition, particularly for controlling herbal compositions in metabolic syndrome.
D 為達上述目的’依本發明之可控制代謝症候群之中 草藥組成物’其包含咸豐草（Bidens pi i〇sa);以及人蔘 (Panax ginseng)，其中，其成份為70_90重量百分比之咸 豐草（Bidens pi losa);以及10-30重量百分比之人蔘（panax ginseng)’其較佳比例為8〇重量百分比之咸豐草與2〇重量 百分比之人蔘。 本發明之控制代謝症候群之中草藥組成物，其組成 包含咸豐草及人蔘’其具有促進胰島素分泌的作用與降 200946123 低胰島素抗性的作用，可以調節人體内血糖值，適用於 糖尿病患者之治療。 茲為使貴審查委員對本發明之技術特徵及所達成 之功效有更進一步之暸解與認識，下文謹提供較佳之實 施例及相關圖式以為輔佐之用，並以詳細之說明文字配 合說明如後。 【實施方式】 Ο - 本發明係有關於一種用以控制代謝症候群之中草藥 組成物，主要係由下列成分組成：咸豐草及人蔘，其成 份為70-90重量百分比之咸豐草（Bidens pilosa)，以及 10-30重量百分比之人蔘（Panax ginseng)，其較佳比例為 80重量百分比之咸豐草與20重量百分比之人蔘。各成分之 特性簡要說明如下： 1.咸豐草（Bidens pilosa) 咸豐草屬菊科鬼針屬，常見的有大花咸豐草、小花 ° 咸豐草及鬼針草。文獻指出，咸豐草内有許多化學結構 不同的植物二級代謝物，包括黃酮類、苯基丙酸類、聚 乙炔類等，可用來做為消暑降火的青草茶，有清熱、解 毒、利尿、散#之功效，並能治療腸胃道疾病與細菌感 染發炎。根據眾多科學文獻及過去的研究發現，廣泛分 布在非洲、美洲及亞洲大陸之咸豐草經常被用來作為治 療發炎及糖尿病等疾病，使用整株大花咸豐草，可以控 制四氧哺咬（Alloxan)所誘導的糖尿病（Maries)。另外，大 200946123 花咸豐草正丁醇萃取物亦被證實能藉由調節免疫系統的 方式來預防第一型糖尿病（自體免疫型糖尿病）。 關於咸豐草的作用機制探討，目前普遍認為此植物 可能具有促胰島素分泌劑的特性，也就是其能促進胰島 細胞分泌胰島素。進一步對咸豐草萃取物進行分析後， 發現執行降血糖功能的物質為一種被稱為聚乙炔類的化 合物。值得注意的是，咸豐草的甲醇萃取物與聚乙炔類 - 在第二型糖尿病鼠模式中有降血糖活性的功效。 ❹ 2.人蔘（Panax ginseng) 人蔘中的CK(Compound K)能夠增加血漿中脂聯素 (adiponectin)的水平，啟動負責脂肪新生及葡萄糖運送蛋 白的基因，因而增加了胰島素的反應，除了 CK，RH2(人 蔘皂苷）也被證實可透過增加胰島素敏感性的方式來調節 血糖。 簡單地說，本發明之控制代謝症候群之中草藥組成 物，其為透過咸豐草内之聚乙炔類等化合物成分，促進 ❹胰島素分泌，並透過人蔘中的Ginoside，增加胰島素之 敏感性，達到控制代謝症候群之功效。 本發明之控制代謝症候群之中草藥組成物，其具有 調節血醣功能的作用，可用於控制糖尿病。 本發明之控制代謝症候群之中草藥組成物，具有促 進胰島素分泌的作用。 本發明之控制代謝症候群之中草藥組成物，具有降 低胰島素抗性的作用。 根據本發明之控制代謝症候群之中草藥組成物，其 200946123 可製成錠劑、顆粒、粉末、液劑、膠囊或蜜丸等不同型 態’此外’本發明之控制代謝症候群之中草藥組成物可 添加至飲料、代餐、或其他可食用之產品，供消費者方 便飲用。 另外，本發明之控制代謝症候群之中草藥組成物， 其中咸豐草與人蔘為萃取物之形式，較佳地為水萃取物形 式。 - 試驗例說明： ° 茲以下列實例予以詳細說明本發明，唯並不意味本 發明僅侷限於此等實例所揭示之内容。 【本發明之中草藥組合物之準備】 本發明戶/H吏用之咸豐草，為使用其全草植物，產地 不限；而人參無部位及產地等限制。 較佳地，咸豐草所使用部位為葉莖部位植株，植株 同度為60〜150公分，以未開花為宜。產地以亞熱帶區域 ❹為佳，採收季節以夏秋兩季為宜，且可使用新鮮植株， 或採收後予以曬乾，曝曬時間不宜過長，植株曬乾後需 切成2〜10cm小段，以增加萃取效果。 較佳地，人參採用韓國產四年生以上等級紅參，曬 乾後切成直徑2〜5cm片狀。 首先，將上述兩種中藥材分別乾燥磨粉，混合後以 熱水進行萃取。萃取程序可分三次，第一次萃取方法為 主原料30〜50kg，加入過濾後的乾淨清水5〇〇〜1〇〇此，清 水體積為原料的20〜40倍，以8〇〜1〇〇度熱水加熱3〇〜5〇 200946123 分鐘，液體過濾後，進行濃縮；同樣的主原料進行第二 次萃取，加入過濾後的乾淨清水500〜1 〇〇〇l，清水體積為 原料的20〜40倍，以80〜100度熱水加熱40〜70分鐘，液 體過濾後，進行濃縮；同樣的主原料進行第三次萃取， 加入過濾後的乾淨清水500〜1000L，清水體積為原料的 20〜40倍，以80〜100度熱水加熱40〜70分鐘，液體過濾 後，進行濃縮。 濃縮液收集並濃縮至液體濃度20〜50%，進行熱風喷 ® 霧或冷凍乾燥成為粉末；乾燥粉末’以一前述之重量百 分比比例進行混合，並添加賦形劑，最後製成本發明之 中草藥組合物（MetaJust)。 【本發明之中草藥組合物（MetaJust)與咸豐草（bp)之比 較】 為了暸解本發明之中草藥組合物（MetaJust)與習知之 單方咸豐草（BP)對糖尿病患者之血醣控制效果之差異 性。本實驗分成兩部份進行，其一為長期空腹血糖試驗， 其二為短期餐後血糖試驗。實驗對象為針對經認證過之 第二型糖尿病小鼠（db/db mice)試驗，並將其分成三組， 一為對照組，為服用同量溶媒（vehicle)之糖尿病小鼠、一 為服用單方大花咸豐草之糖尿病小鼠之實驗組、與一服 用本發明之中草藥組合物之糖尿病小鼠之實驗組。 請參照圖一，係顯示糖尿病小鼠在長期空腹血糖試 驗（Fasting blood glucose test: long-term administration) 200946123 之影響結果’其試驗結果顯示在第七天時，糖尿病小鼠 無論服用咸豐草或是本發明之中草藥組合物，空腹血糖 皆與對照組有顯著差異，然而第十四天結果顯示，僅有 服用本發明之中草藥組合物組保有控制效果，這代表在 長期控制的效果上，本發明之中草藥組合物優於大花咸 豐草。 請參照圖二，係顯示糖尿病小鼠在短期餐後血糖試 驗（Postprandial blood glucose test : short-term ® administration )之結果，其試驗結果顯示在短期餐後血 糖試驗中，MetaJust組的血糖下降趨勢與BP組相似，代 表在短期治標的效果上，兩者不分軒輊。 【本發明之中草藥組成物（MetaJust)之動物實驗數據】 以下，係透過不同的血糖觀測方法，觀察第二型糖 尿病小鼠（db/db mice )服用本發明之中草藥組成物 (MetaJust)之血糖變化，其試驗内容包含：短期口服葡萄 糖耐受試驗（Oral glucose tolerance test : short-term administration )、短期空腹血糖試驗（Fasting blood glucose test : short-term administration )、短期餐後血糖 試驗（Postprandial blood glucose test : short-term administration )、長期口服葡萄糖对受試驗結果（Oral glucose tolerance testt · long-term administration)與長 期空腹血糖試驗（Fasting blood glucose test : long-term administration)，另外，亦會針對患有糖尿病之小鼠觀察 12 200946123 其騰島素值之變化（Blood insulin test : short-term administration)。 在鲁察糖尿病小鼠之血糖變化試驗中，實驗對象同 樣為針對經認證過之第二型糖尿病小鼠（db/db mice )， 並將其分成二組，一為服用同量溶媒（vehicle)之糖尿病小 鼠為對照組、與一服用本發明之中草藥組成物之糖尿病 小鼠之實驗組。 首先，針對糖尿病小鼠進行短期口服葡萄糖耐量實 〇驗，將患有糖尿病小之小鼠空腹隔夜，後餵食每公斤含 一公克之葡萄糖，其30分鐘後分別再餵食溶媒與本發明 之中草藥組合物，請參考第3圖，係顯示糖尿病小鼠進 行短期口服葡萄糖耐受實驗之血糖變化結果，其實驗結 果顯示服用本發明之中草藥組成物之糖尿病小鼠，其血 糖值變化範圍較服用溶媒之糖尿病小鼠低，其血糖亦較 快恢復到正常值範圍。 另外，針對糖尿病小鼠進行短期空腹血糖試驗，請 〇 參考第4圖，係顯示糖尿病小鼠進行短期空腹血糖試驗 之結果，其實驗結果顯示糖尿病小鼠食用本發明之中草 藥組成物後，其空腹血糖值會降低。 另外，針對糖尿病小鼠進行短期餐後血糖試驗，將 患有糖尿病小之小鼠空腹隔夜後餵食，1小時後分別再餵 食溶媒與服用本發明之中草藥組成物，請參考第5圖， 係顯示糖尿病小鼠進行短期餐後血糖試驗之結果，其實 驗結果顯示糖尿病小鼠食用本發明之中草藥組成物後， 其餐後血糖值下降程度較對照組快。 13 200946123 另外，針對糖尿病小鼠進行長期口服葡萄糖耐受試 驗結果，請參考第6圖，係顯示糖尿病小鼠進行長期口 服葡萄糖耐量試驗結果，其試驗結果顯示於32天後，長 期服用本發明之中草藥組成物之糖尿病小鼠，其血糖值 曲線均較對照組低。 另外，針對糖尿病小鼠進行長期空腹血糖試驗，請 參考第7圖，係顯示糖尿病小鼠進行長期空腹血糖試驗 結果，其實驗結果顯示14天後，服用本發明之中草藥組 〇成物之糖尿病小鼠，其血糖值較對照組為低。 最後，針對糖尿病小鼠進行其胰島素值之觀察，請 參考第8圖，係顯示糖尿病小鼠之胰島素值變化，將患 有糖尿病小之小鼠空腹隔夜，後餵食每公斤含一公克之 葡萄糖，其30分鐘後分別再餵食溶媒與本發明之中草藥 組成物，其中pre-dose組為服用藥物之前之胰島素值， 服用溶媒之糖尿病小鼠為對照組，服用本發明之中草藥 組成物為實驗組，其結果可發現，服用本發明之中草藥 ❿組成物之胰島素值含量較服用藥物之前之胰島素值組與 對照組均為高。 上述實施例僅為說明本發明之原理及其功效，而非 限制本發明。因此，習於此技術之人士對上述實施例所 做之修改及變化仍不違背本發明之精神。本發明之權利 範圍應如後述之申請專利範圍所列。 【圖式簡單說明】 第1圖係為糖尿病小鼠在長期空腹血糖試驗（Fasting 14 200946123 blood glucose test : long-term administration) 之試驗結果； 第2圖係為糖尿病小鼠在糖尿病小鼠在短期餐後血糖 试驗（Postprandial blood glucose test · short-term administration)之試驗結果； 第3圖係為糖尿病小鼠在糖尿病小鼠在短期口服葡萄 糖耐量試驗（Oral glucose tolerance test : short-term administration)之試驗結果 第4圖係為糖尿病小鼠在短期空腹血糖試驗（Fasting blood glucose test * short-term administration) 之試驗結果； 第5圖係為糖尿病小鼠在短期餐後血糖試驗 (Postprandial blood glucose test '· short-term administration)之試驗結果； 第6圖係為糖尿病小鼠在長期口服葡萄糖耐量試驗 (Oral glucose tolerance testt : long-term O administration)之試驗結果； 第7圖係為糖尿病小鼠在長期空腹血糖試驗（Fasting blood glucose test · long-term administration) 之試驗結果 第8圖係為糖尿病小鼠騰島素值之變化（Blood insulin test: short-term administration )之試驗結果。 【主要元件符號說明】 無 15D is a herbicidal composition of the controllable metabolic syndrome according to the present invention, which comprises Bidens pi i〇sa; and Panax ginseng, wherein the composition is 70-90% by weight of the salty grass. (Bidens pi losa); and 10-30% by weight of panax ginseng 'the preferred ratio is 8 〇 weight percent of yam grass and 2 〇 weight percent of human 蔘. The herbal composition of the control metabolic syndrome of the present invention comprises a salty grass and a human cockroach which has the function of promoting insulin secretion and lowering the insulin resistance of 200946123, and can regulate the blood sugar level in the human body, and is suitable for the treatment of diabetic patients. . In order to provide a better understanding and understanding of the technical features and the efficacies of the present invention, the preferred embodiments and related drawings are provided for the purpose of assistance, and the detailed descriptions are followed by a description. . [Embodiment] Ο - The present invention relates to a herbal composition for controlling metabolic syndrome, which is mainly composed of the following components: salty grass and human cockroach, and its composition is 70-90% by weight of Bidens pilosa. And 10-30% by weight of Panax ginseng, preferably in a ratio of 80% by weight of yam grass and 20% by weight of cockroach. The characteristics of each component are briefly described as follows: 1. Bidens pilosa The genus Bidens pilosa is a genus of the genus Asteraceae. Commonly, there are large flowers, salty grasses, small flowers, salty grasses and snails. The literature pointed out that there are many plant secondary metabolites with different chemical structures in Xianfeng Grass, including flavonoids, phenylpropionic acid, polyacetylene, etc. It can be used as a herbal tea for heatstroke and heat reduction, with heat, detoxification and diuresis. The effect of San, and can treat gastrointestinal diseases and bacterial infections. According to numerous scientific literatures and past studies, salty grasses widely distributed in Africa, the Americas, and the Asian continent are often used to treat diseases such as inflammation and diabetes. The whole plant can be used to control tetraoxine (Alloxan). ) induced diabetes (Maries). In addition, the large 200946123 sylvestre extract of n-butanol has also been shown to prevent type 1 diabetes (autoimmune diabetes) by regulating the immune system. Regarding the mechanism of action of Xianfengcao, it is generally believed that this plant may have the characteristics of an insulin secretagogue, that is, it can promote insulin secretion from islet cells. Further analysis of the extract of Xianfeng grass revealed that the substance performing the hypoglycemic function was a compound called polyacetylene. It is worth noting that the methanol extract and the polyacetylene of Xianfengcao have the effect of lowering blood glucose activity in the second type diabetic rat model. ❹ 2.Panax ginseng CK (Compound K) in human sputum can increase the level of adiponectin in plasma and activate the genes responsible for fat nascent and glucose transport proteins, thus increasing insulin response, CK, RH2 (human saponin) has also been shown to regulate blood sugar by increasing insulin sensitivity. Briefly, the herbal composition for controlling metabolic syndrome of the present invention is a compound component such as polyacetylene in the salty grass, which promotes insulin secretion and increases the sensitivity of insulin through the Ginoside in the human sputum to achieve control. The efficacy of metabolic syndrome. The herbal composition for controlling metabolic syndrome of the present invention has an action of regulating blood sugar function and can be used for controlling diabetes. The herbal composition of the present invention for controlling metabolic syndrome has an effect of promoting insulin secretion. The herbal composition of the present invention for controlling metabolic syndrome has an effect of lowering insulin resistance. According to the present invention, the composition of the herbal medicine for controlling metabolic syndrome can be made into various types such as tablets, granules, powders, liquids, capsules or honey pills. In addition, the herbal composition of the metabolic syndrome of the present invention can be added. To beverages, meal replacements, or other edible products for the convenience of consumers. Further, the herbal composition for controlling metabolic syndrome of the present invention, wherein the salty grass and the human cockroach are in the form of an extract, preferably in the form of an aqueous extract. - EXPERIMENTAL EXAMPLES: The following examples are given to illustrate the invention in detail, and are not intended to limit the invention to the disclosure. [Preparation of the Herbal Medicine Composition of the Present Invention] The salty grass of the present invention is not limited to the use of the whole grass plant, and the ginseng has no limitation on the place and the place of production. Preferably, the planting part of the salty grass is a plant of the leaf stem, and the plant is 60 to 150 cm in the same degree, and the flowering is not suitable. The production area is preferably in the subtropical region. The harvest season is suitable for summer and autumn. Fresh plants can be used, or dried after harvesting. The exposure time should not be too long. After drying, the plants should be cut into 2~10cm sections. To increase the extraction effect. Preferably, the ginseng is made of Korean red ginseng of four or more years, dried and cut into 2~5 cm pieces. First, the above two kinds of Chinese herbal medicines are separately dried and ground, and then mixed and extracted with hot water. The extraction procedure can be divided into three times. The first extraction method is 30~50kg as the main raw material, and the cleaned water after filtration is added 5〇〇~1〇〇, the volume of the clean water is 20~40 times of the raw material, and 8〇~1〇〇 Degree of hot water heating 3〇~5〇200946123 minutes, liquid filtration, concentration; the same main raw material for the second extraction, adding clean water after filtration 500~1 〇〇〇l, the volume of water is 20~ 40 times, heated with 80~100 degrees of hot water for 40~70 minutes, liquid filtration, concentration; the same main raw material for the third extraction, adding clean clean water 500~1000L, the volume of water is 20~ 40 times, heated with 80 to 100 degrees of hot water for 40 to 70 minutes, filtered with liquid, and concentrated. The concentrate is collected and concentrated to a liquid concentration of 20 to 50%, subjected to hot air spray® mist or freeze-dried to a powder; the dry powder is mixed at a ratio by weight of the foregoing, and an excipient is added, and finally the herbal composition of the present invention is prepared. Matt (JetaJust). [Comparison of MetaJust and Xianfeng Grass (bp) of the present invention] In order to understand the difference in the blood sugar control effect of the Chinese herbal medicine composition (MetaJust) and the conventional single salty grass (BP) on diabetic patients. The experiment was divided into two parts, one for long-term fasting blood glucose test and the other for short-term postprandial blood glucose test. The subjects were tested against certified type 2 diabetic mice (db/db mice) and divided into three groups, one for the control group, the diabetic mice taking the same amount of vehicle, and the other for taking An experimental group of a diabetic mouse of unilateral safflower and a diabetic mouse of a Chinese herbal composition of the present invention. Please refer to Figure 1 for the results of the effect of the fasting blood glucose test (long-term administration) 200946123 on the diabetic mice. The results of the test showed that on the seventh day, the diabetic mice took either salty grass or In the herbal composition of the present invention, fasting blood glucose is significantly different from the control group, however, the results on the fourteenth day show that only the group of the herbal composition of the present invention is administered with a control effect, which means that the present invention has the effect of long-term control. The herbal composition is superior to the large flower salty grass. Referring to Figure 2, the results of the Postprandial blood glucose test (short-term ® administration) of diabetic mice are shown. The results of the test show that the blood glucose decline trend of the MetaJust group in the short-term postprandial blood glucose test The BP group is similar, representing the effect of short-term treatment, and the two are not different. [Animal data of the herbal composition of the present invention (MetaJust)] Hereinafter, blood glucose of the Chinese herbal medicine composition (MetaJust) of the present invention is observed by using a different blood glucose observation method to observe a type 2 diabetic mouse (db/db mice). Changes include: Oral glucose tolerance test: short-term administration, short-term fast glucose test (short-term administration), short-term postprandial blood glucose test (Postprandial blood glucose) Test : short-term administration ), long-term oral glucose test (Oral glucose tolerance testt · long-term administration) and long-term fasting blood glucose test (long-term administration), in addition, Diabetes mice observed 12 200946123 its blood insulin test (short-term administration). In the blood glucose change test of Ruza diabetic mice, the subjects were also directed against certified type 2 diabetic mice (db/db mice), and divided into two groups, one taking the same amount of vehicle (vehicle). The diabetic mice were a control group and an experimental group of diabetic mice to which the herbal composition of the present invention was administered. First, a short-term oral glucose tolerance test was performed on diabetic mice. The mice with diabetes mellitus were fasted overnight, and then fed with one gram of glucose per kilogram. After 30 minutes, they were fed with a medium and a combination of the Chinese herbal medicines of the present invention. For the substance, please refer to Fig. 3, which shows the results of blood glucose changes in short-term oral glucose tolerance test in diabetic mice. The experimental results show that the diabetic mice taking the Chinese herbal composition of the present invention have a blood sugar value ranging from the solvent to the solvent. Diabetic mice are low, and their blood sugar is also quickly restored to normal values. In addition, for short-term fasting blood glucose test in diabetic mice, please refer to Figure 4, which shows the results of short-term fasting blood glucose test in diabetic mice. The experimental results show that diabetic mice eat the Chinese herbal medicine composition of the present invention and have an empty stomach. The blood sugar level will decrease. In addition, a short-term postprandial blood glucose test was performed on diabetic mice, and mice with diabetes mellitus were fed overnight after fasting, and after 1 hour, the vehicle was further fed with the medium and the herbal composition of the present invention, please refer to Fig. 5, The results of short-term postprandial blood glucose test in diabetic mice showed that the diabetic mice consumed the Chinese herbal medicine composition of the present invention, and the postprandial blood glucose level decreased more rapidly than the control group. 13 200946123 In addition, the results of long-term oral glucose tolerance test for diabetic mice, please refer to Figure 6, which shows the results of long-term oral glucose tolerance test in diabetic mice. The test results show that after 32 days, the invention is taken for a long time. The blood glucose curve of diabetic mice with Chinese herbal medicine composition was lower than that of the control group. In addition, for long-term fasting blood glucose test in diabetic mice, please refer to Figure 7, which shows the results of long-term fasting blood glucose test in diabetic mice. The results of the experiment show that after 14 days, the diabetes of the Chinese herbal medicine group of the present invention is small. The blood glucose level of the rats was lower than that of the control group. Finally, for the observation of the insulin value of diabetic mice, please refer to Figure 8, which shows the change of insulin value in diabetic mice. The mice with diabetes mellitus were fasted overnight, and then fed one kilogram of glucose per kilogram. After 30 minutes, the solvent and the Chinese herbal medicine composition of the present invention were respectively fed, wherein the pre-dose group was the insulin value before taking the medicine, the diabetic mice taking the solvent was used as the control group, and the Chinese herbal medicine composition of the present invention was used as the experimental group. As a result, it was found that the insulin value of the herbal sputum composition of the present invention was higher than that of the insulin group before the administration of the drug. The above-described embodiments are merely illustrative of the principles of the invention and its effects, and are not intended to limit the invention. Therefore, modifications and variations of the embodiments described above will be made without departing from the spirit of the invention. The scope of the invention should be as set forth in the appended claims. [Simplified illustration] Figure 1 shows the results of a long-term fasting blood glucose test (Fasting 14 200946123 blood glucose test: long-term administration); Figure 2 shows a diabetic mouse in a short-term diabetes mouse. Postprandial blood glucose test (short-term administration) test results; Figure 3 is a diabetic mouse in the diabetic mouse in the short-term oral glucose tolerance test (Oral glucose tolerance test: short-term administration) The results of the test are shown in Figure 4 for the results of the short-term fast-term administration of diabetic mice. The fifth picture shows the postprandial blood glucose test in diabetic mice. · Short-term administration test results; Figure 6 shows the results of long-term oral administration test (Oral glucose tolerance testt: long-term O administration) in diabetic mice; Figure 7 shows the long-term oral administration of diabetic mice. Fasting blood glucose test (long-term adm) Test results of inistration Fig. 8 is a test result of a blood insulin test (short-term administration). [Main component symbol description] None 15