TW200938247A - System and apparatus for dermatological treatment - Google Patents

Abstract

Exemplary embodiments of system and apparatus can be provided for treating various dermatological and biological conditions using electromagnetic energy in the form of optical radiation. For example, energy can be provided by a chemical reaction, such as by combustion of a fine metallic filament, which can be used to generate a high-intensity pulse of energy without requiring external energy sources. Various parameters of the reactive materials and enclosures can be selected and/or applied to provide a radiation pulse having particular characteristics, including fluence, peak intensity, and radiation wavelength distribution. Various filters may be provided to further modify characteristics of the radiation. Such radiation pulses can be used to irradiate tissue such as skin to obtain various therapeutic or beneficial effects, including improvement in the appearance of pigmented or venous lesions.

Description

200938247 VI. INSTRUCTIONS OF THE INVENTION: TECHNICAL FIELD OF THE INVENTION The present invention relates to a method and apparatus for treating skin using electromagnetic radiation. More specifically, it relates to illuminating skin tissue with light radiation generated by, for example, a chemical reaction in a combustion lamp. Method, system and equipment for the target location. 〇 【Prior Art】 There is an increasing demand for repair or improvement of skin defects caused by aging, sun exposure, skin diseases, traumatic effects, and heredity. Certain treatments can illuminate the skin by electromagnetic energy to improve skin defects, which can result in a favorable response to improve the condition of the skin being treated. Specifically, the energy provided by optical radiation can be used in a variety of skin treatments. Optical radiation can include electromagnetic radiation, ultraviolet radiation, and/or infrared radiation having one or more wavelengths 〇 in the visible spectral range. The light radiation can be absorbed by the biological tissue, and the above absorption depends on the wavelength and intensity of the radiation, the characteristics of the tissue and/or the specific biological structure, or the chemical compounds therein. Absorption of light energy in biological tissue can generate heat and/or destroy physical structures and/or certain biological functions in the woven fabric, which in turn leads to prolonged benefit or therapeutic effects. Skin treatment with light light exposure may include, for example, removal of tattoos or hair, reduction of acne or venous or pigmented disease 1 arachnoid blood or wine stains, and removal of sensitive lines. : 4 200938247 In the demonstration application, radiation is usually transmitted from an external energy source and is supplied to the target area of the tissue. It is generally preferred to provide one or more of the energy pulses with a sharp peak and a short period of peak energy to provide the above-mentioned energy to counteract the desired biological reflections and electrons in the tissue. The energy source providing the above energy may include any one of a variety of lightning flashes and the like. Optical arrangements (such as oil 逡-, + ^ waveguides or optical fibers, and may include one or more lenses, prisms, reflectors, etc., to sneak) may be utilized to direct the amount of energy from the energy source to the skin organization. The optical cloth β splicer can focus or direct energy to the target area of interest. For example, the above radiation may preferably be absorbed by portions of the skin or hair, such as &apos;black, pigment or blood vessels, resulting in localized heating. Common devices used in the above treatments to provide energy (e.g., light light) to the skin or other tissues can include hand-held components and the like that can be easily changed in position relative to the patient. The above-mentioned hand-held parts can be made by Tian Zhong, who is used to guide the energy provided by the optical arrangement to one or more specific target areas to be treated.常见 There are many safety issues with the common methods and equipment for applying energy to skin tissue as described herein. For example, an 'energy source (such as a laser or an electronic flash) causes a significant risk of overexposure (eg, directing excess energy to the tissue), and without careful control and application of the above energy can cause undesired and potentially significant damage to the tissue. . Sound temples, 丄 _ ^ ° often provide safety precautions when applying extended demonstration energy sources. For example, 'a device that includes a laser or other external source of energy typically includes - or more control arrangements that can regulate, limit, and/or turn off the energy output under certain conditions to reduce the risk of skin tissue being overexposed to the applied radiation. . The above arrangement may include, for example, a pulse arrangement (configured with a pulsed energy source rather than providing continuous energy), which may also avoid overheating of the energy source 5 200938247. Alternatively or additionally, if the handpiece is transferred through the skin area to direct energy to the skin&apos;, a speed or position sensor coupled to the handpiece can be provided to avoid overexposure. A feedback arrangement can also be provided to control the energy source, and the anti-town arrangement can be configured to reduce or interrupt the energy output of the energy source by detecting a dangerous condition. The feedback arrangement described above is based on measured temperature, reflectivity or other image characteristics of the tissue to be treated, and the like. These safety devices add complexity and cost to a variety of energy application systems. Further safety measures are also required for common energy sources that can be used in the above treatments. For example, a laser energy source requires eye protection for the device operator and/or the patient to be treated, limited access to the area where the energy source is to be operated, a large amount of user training, and the like. It is also a common responsibility to provide optical energy to common equipment in biological tissues, and some doctors or other practitioners have difficulty using the above equipment due to economic factors. The treatment provided by the above devices is also blame for patients and/or health insurers. Furthermore, some devices are only available for specific treatments. Therefore, depending on factors such as economic factors, limited storage in medical facilities: doors, etc., it is impractical for practitioners to have multiple of these devices to provide extensive forest management: Moreover, maintaining the above equipment is also an ang #. &quot;Therefore, there is a need to provide an exemplary embodiment of a device and method for safe, effective, and economical therapeutic application of light to skin tissue to modify defects and other treatments. IMPROVED 皮皮 [Abstract] 6 200938247 The object of the present invention is to provide an exemplary embodiment of a system and apparatus for promoting safe and economical treatment to improve skin defects and other treatments including the application of light radiation to skin tissue. Another object of the present invention is to provide an exemplary embodiment of a system and apparatus that can be used in many of the above treatments such that a single practitioner can treat a variety of skin conditions without significant financial investment equipment (such as energy sources, handpieces, etc.) and / or obvious storage space to accommodate the above devices. A further object is to provide an exemplary embodiment of the above-described method of treating skin symptoms, which is sufficiently safe to be applied by a consumer at home. These and other objects can be achieved by an exemplary embodiment of the system and apparatus in accordance with the present invention, wherein a source of radiation configured to generate one or more pulses of optical radiation from a chemical reaction can be provided. The radiation source can include a sealed enclosure that includes a reactive material (eg, a combustible material). The enclosure may be formed from glass, plastic or another material or combination of materials, such as a plastic or polymer coated glass. For example, the radiation source can be a combustion lamp or the like. Any reactive material that is capable of producing a sufficiently strong radiation pulse as described herein when subjected to a chemical reaction can be applied. The combustible material may be a metal or a metal alloy such as aluminum, sea aluminum, aluminum alloy or another metal, or a combination of metal and another material. The combustible material can be provided in the form of a filament or foil to allow the material to undergo a rapid catch response (e.g., burning eight of the above rapid reactions can produce radiation pulses of high intensity and short period (e.g., enthalpy, tens of milliseconds or less). Specific air may be provided in the enclosure to enhance or enhance the reaction or combustion. The air may include, for example, between about 100% anhydrous oxygen, or about 80% and about (10)% 7 200938247. An exemplary ignition arrangement may also be provided in the enclosure to assist in initiating the chemical reaction. The exemplary triggering arrangement described above may include providing an initiating substance (iv) bile substa (10)) contacting two or more electrode contacts, the electrode contacts may pass through the enclosure The wall and therefore can be applied outside the self-sealing enclosure. In certain exemplary embodiments of the invention, a triggering arrangement including a drive energy source and a 开关 switch or flip flop may be provided. Drive energy can be provided to the point arrangement to initiate a chemical reaction in the enclosure. The source of drive energy can include, for example, a small battery or an energy battery or a piezoelectric element. In accordance with a further exemplary embodiment of the present invention, a cover configured to support and/or surround the burner lamp pure m at a predetermined distance from the tissue to be treated may be provided. Alternatively or additionally, a closure comprising a reactive or combustible material may also provide the outer cover. In an exemplary embodiment of the present invention, an optical arrangement can be provided to direct the optical radiation produced by the scholastic reaction to the tissue to be treated. The above-described anomalous optical arrangement may include a reflective surface or coating such as provided on at least a portion of the (iv) source outer cover or enclosure. The period of the optical radiation pulse provided by the radiation source is between about _milliseconds, or about 10 milliseconds and about 1 millisecond, or between: 〇 milliseconds and about 50 milliseconds. Longer pulse periods can also be provided, such as a level of about one second or longer. The pulse period described above can be provided by arranging the smuggling, s &amp; M^ 』 precision radiation source and combustible material and/or providing a plurality of radiation sources activated at different times. The light radiation provided by the light source provides a flux to the tissue to be treated 8 ❹ ❿ 200938247 — a) can be interspersed between J/cm and approximately 15 j/cm2 between approximately 1 &quot;1 and approximately 3〇W There is also a need to provide a higher throughput, a larger amount of combustible material, and an approach radiation pulse to a smaller area. In the embodiment of the present invention, one or more of the fading or blocking wavelengths of the radiation source may be provided by one or more of the fading or blocking radiation sources. For example, a filter can be provided to reduce the amount of tissue that is to be treated by ultraviolet light and/or infrared light. Other filter elements may also be provided to eliminate; see radiation at certain wavelengths of the spectrum t. The filter elements described above may be provided in different pieces/or (5) portions of the radiation source enclosure and/or outer cover may be formed from materials providing the above-described filtration and characteristics. In some embodiments, a water hammer can be provided to reduce the amount of infrared radiation generated by the light source. The water filter member described above may be formed as part of or may be attached to the enclosure or the cover. The water filter element can be cooled or cooled to remove some of the infrared radiation and provide cooling to the tissue to be treated. In an exemplary embodiment, a plate comprising one or more apertures may be provided that facilitates the passage of optical radiation therethrough and illuminates a particular area of tissue while avoiding exposure of other portions of the tissue to radiation. A plurality of such panels having apertures of different sizes and/or shapes may be provided which may utilize a single structured source of radiation to illuminate many differently sized lesions, skin defects, and the like. These and other objects, features and advantages of the present invention will become more fully apparent from the < 9 200938247 [Embodiment] A source of optical energy (such as a laser, an electronic flash, etc.) typically used in conventional therapeutic devices can be configured to provide continuous radiation and/or a plurality of radiation pulses over a longer period of time. The above radiation can be provided by converting energy directly or indirectly from an energy source (wall outlet or generator). For example, when connected to a battery or an electrical outlet, the conventional bulb will continue to illuminate and thus illuminate. The above-mentioned optical radiation is not stored in the bulb itself, but is derived from the electrical energy obtained from the outside of the bulb. Rather, exemplary embodiments of the present invention can provide an exemplary embodiment of an apparatus and method for generating and directing a particular amount of optical energy or other radiation onto skin tissue. The above apparatus and method may include a source of optical energy provided by the device itself through a chemical reaction, such as a combustion lamp or a flash bulb. It is configured to produce - or more sufficient pulses of optical radiation when subjected to a spontaneous reaction: any other chemical system, including but not limited to combustion or oxidation reactions, can also be used in the exemplary embodiments of the present invention. The burner lamps provided herein can be referred to as sealed bulbs or other enclosures that include an energy storage form that can utilize lower energy external stimuli or signal release. An example of such a burner lamp may be a conventional photographic flash bulb that can be used to illuminate an object to be photographed. The burner lamp described above can release the energy stored internally, and a single energy bulb can be provided at a time to provide a single energy pulse. This article can alternately apply vocabulary burning lights and flash bulbs. - Figure 1 shows an exemplary diagram of a combustion lamp 100, which may be applied in accordance with an exemplary embodiment of the present invention. For example, the burner 00 may include a closure member 200938247 U 〇 ' which is approximately spherical or may be provided in another shape. The closure member 110 can be formed from a glass plastic or some other material that preferably allows at least some of the wavelength of the radiation to pass through. It can be used to apply a layer of plastic or lacquered glass to the 'two, two cycles' of the material to maintain the sealing material in a long period of time - any of the gases provided by the brother. It contains a piece of glass that breaks up when the burner lamp 100 is activated and emits light energy. - Ο = = =, such as 110 may comprise combustible filaments 120, which may include or be made of a combustible metal such as aluminum, aluminum, or another aluminum alloy, another metal, or the like. Very fine metal wires and / or = for... can be used. . The filament 12&quot;small size helps to promote: = speed response (e.g., oxidation) and can thereby provide a pulse of light energy for the period or pulse "peak intensity". In general, the size of the filament U0 (e.g., 'thin metal wire or box') can result in longer reaction times and longer pulse periods and lower peak output intensity. The second error is formed by the cover 130 or other sealing arrangement to form or seal the filament 12 〇 in the closure member 1 1 。. · The egg twisted selectively forms a sealed arrangement 1:30 for the portion of the two cows 7. Prior to sealing the enclosure 110, air may be removed and: a specified amount and/or pressure level of anhydrous oxygen is provided therein. The enclosure 1 may be provided with anhydrous oxygen such as between about (iv) and about 100%, or anhydrous oxygen of 80% and about 100%. As described herein, the material of the (4) enclosure 11G can be selected to maintain the gas or gas mixture (including the degree of moisture therein) fairly constant over a long period of time. The above-mentioned internal environment of the enclosed #m can improve the reliability and predictability of the performance of the combustion lamp 1〇〇200938247. Can provide a plurality of parts in the seal #110 and cover 13 〇 outside the joint

14〇. The contacts 140 can be electrically contacted with one or more seals in the enclosure 11 nitmer l5G£&gt; The initiator 15G can be similar to those used in conventional flashlight bulbs. A low energy signal can be applied to contact U0 to activate! The hair piece 15G, for example, causes its burning. The above signals can be used for functions such as batteries, battery components, and the like. The active action of the initiator 150 can cause a rapid chemical reaction (e.g., oxidation) of the filaments 12 in the weir 110, which can release a significant amount of energy from the enclosure 11 in a relatively short period of time. For example, the pulse width of the optical radiation pulse provided by the activation of the exemplary combustion lamp is, for example, on the order of tens of milliseconds. The above pulse width or period may be between, for example, about 1 〇 milliseconds and/or about (10) milliseconds or more, or preferably about 10 to 50 milliseconds. Furthermore, the peak intensity of the radiation pulse also occurs at about 2 〇 5 〇 milliseconds after activation of the burner lamp 100. The pulse delays described above for a particular burner 10&quot; are dependent on a number of factors including, for example, the size of the bulb, the average diameter, width and/or number of filaments 120 used, the structure of the filament 120 in the enclosure #13, #13&quot; The amount of oxygen supplied, etc. For example, the thicker filaments 120 can provide longer pulse delays because the oxidation of the thicker filaments is slower relative to the finer filaments. An illustration of an exemplary device 2A in accordance with some embodiments of the present invention is shown in FIG. An exemplary combustion lamp 1 〇〇 can be provided in the housing 22 。. An activation cloth can be attached to the material 220 to provide an activation cloth, and it is more electrically connected 12 200938247 to the combustion lamp 100. The activation arrangement 230 further includes a switch and/or a button 24 that facilitates the supply of electrical signals to the combustion lamp 1 when the button 240 is depressed (^the burner 100 can then release the energy stored therein, such as "flash" or short cycle A strong optical radiation pulse. The exemplary outer cover 220' can be provided in a shape such as a bell, hemisphere, etc. and configured to be placed over or over the area surface 270 of the skin tissue 280 to be treated. The outer cover 220 can also include a reflective surface or Coating or ❹ Other optical arrangement configured to direct a greater amount of light released by the combustion lamp 1 辐射 to the skin 280 to be treated. The exemplary optical arrangement described above can thereby efflux the efficiency of the particular combustion lamp 100. Promoting the exemplary combustion lamp 100 provides higher intensity and/or flux of radiation to the skin tissue 280. Alternatively or additionally, an increase in efficiency may facilitate a smaller bulb (eg, 'bulb 00 containing a smaller amount of combustible material) Specific strength and/or flux is provided to the skin tissue 280. The activation arrangement 230 can include, for example, a small battery, a dust electrical element, or any other energy source thereof that can be configured to The combustion apparatus may be provided as a disposable device. Alternatively or additionally, the combustion lamp 1 may be replaced so that the outer cover 220 and/or the activation arrangement 230 may be reused. Certain exemplary embodiments of the invention The device 200 can provide one or more selective filter elements 250. The filter element 250 can be located between the combustion lamp 1A and the skin surface 270. For example, a filter member 250 can be provided in the housing 220. Alternatively or additionally The filter element 250 can be located at a lower position on the surface of the outer cover 220 such that it can contact the surface 270 of the skin 280. The filter element 250 can be configured to, for example, avoid or partially inhibit certain wavelengths or wavelengths emitted by the combustion lamp 1 〇〇13 200938247 The range of light radiation reaches the portion of the skin tissue to be treated 280. The above wavelength or range of wavelengths may be selected depending on the particular defect or symptom to be treated. If the filter member 250 is provided, the filter member 25 is movable to accommodate many One of the filter elements 250 described above (each of which may be configured to inhibit transmission of optical radiation of different wavelengths and/or wavelength ranges) may be used with a single type of exemplary combustion lamp 100, for example, for a single The outer cover 22 is or in a plurality of outer covers 10. In this manner, the energy output of a single type of combustion lamp 100 is characterized, modified or modified to improve the efficiency and/or safety of a particular application. For example, the filter 250 can be An ultraviolet (uv) filter element that can be provided to avoid, for example, most of the optical radiation having a wavelength shorter than about 6 〇〇 nm or shorter than about 55 〇 nm is irradiated onto the tissue to be treated. The above uv filter is usually used and applied. A conventional phototherapy device for a broadband optical radiation source, such as a strong pulsed light source and/or an electronic flash. The filter member 250 can also be configured or constructed to attenuate or block at least a portion of the light generated by the combustion lamp in the infrared range. . For example, a water filter can be used to reduce the amount of light radiation having a wavelength between about 9 〇〇 nm and about u 〇〇 _13 照射 illuminating the tissue to be treated. The water filter element can include a shallow enclosure or container (at least partially filled with water) provided between the source of optical radiation 100 and the tissue to be treated 28〇. For example, the water filter, member may be attached to the lower portion of the outer cover 220. The water filter described above can also be used in some conventional phototherapy devices that utilize broadband optical radiation sources. An exemplary apparatus structure for use in the exemplary embodiment of the present invention is shown in Figure 3. For example, the above exemplary apparatus may include a combustion lamp 100 for use in the outer cover 220 and an activation arrangement 230 provided in conjunction with the outer cover 220. The activation arrangement 23 may further include a switch/button 240' when it is triggered. Causes an electronic signal to be supplied to the burner. The exemplary device 3〇0 can be provided in the general shape shown in Fig. 3 so that it is easily grasped by hand and pressed against the surface 270 of the skin 28 to be treated. In this exemplary configuration, when the outer cover 22 and the activation arrangement 23 are grasped in the hand, it is easy to press the switch/button 240 by, for example, the thumb of the user, similar to the exemplary device 200 shown in FIG. 2, the cover A portion of 220 may be provided with a reflective surface or coating to direct light radiation from the combustion lamp 100 toward the skin to be treated. In a further exemplary embodiment of the present invention, an apparatus 400 including a plurality of burners 1 in a single housing 220 as shown in FIG. 4 may be provided. For example, the 'combustion lamp 100 can be selectively coupled to a single activation arrangement 23A such that each burner 1 can be simultaneously activated by a single button 240. This non-standard structure can be achieved by a single burner lamp 1 in the device 2 shown in Fig. 2, which promotes a higher flux reaching the skin tissue. The exemplary device 400 can also include a large outer cover 22 that can provide a particular flux value to a larger area of the skin 280 (relative to the single light bulb device 200 shown in Figure 2). Alternatively or additionally, the activation arrangement 23A can be coupled to a single burner 100' such that only one of the above bulbs 1 is directly activated when the button 24 is depressed. For example, the energy released by the activated combustion lamp can further activate adjacent combustion lamps. Thus, the single burner lamp 100 activated by the activation arrangement 23A can then activate the other burner lamps 1 after a predetermined delay. 15 200938247 The above delay can be on the order of tens of milliseconds, and the amount of delay is further dependent on the characteristics of each burner. In this manner, the radiation provided by the burner can be achieved by providing more than one of the above-described bulbs 100 in the single-outlet cover 220 and directly activating only one of the burners 100. This approach allows for the provisional extended release of optical radiation in the form of a plurality of continuous or non-simultaneous pulses facilitated by a plurality of burner lamps.

The illustration of the further exemplary device 50G in accordance with the further embodiments of the present invention is shown in Figure 5A. As described herein, the exemplary apparatus 5A can include a side wall 510 and a bottom surface 520 that together form an enclosure that includes combustible filaments 120 and an initiator 15〇. The activation arrangement 23A and the switch 240 can be replaced or permanently mounted on or in the enclosure. The exemplary device 5 can be used to provide an optical radiation pulse to the area of the skin tissue 280 located beneath the device 5〇〇. The exemplary device 500 can be provided with a bell-like or hemispherical shape as shown in Figure 5A, which preferably has an approximately circular shape (viewed from above). Other exemplary shapes can also be used for certain applications. For example, device 5〇〇 There may be an elliptical shape or a generally rectangular shape (viewed from above), for example if the upper shape preferably conforms to the area of the skin tissue 280 to be treated. The device 5〇〇 may be configured to be placed in direct contact with the surface 270 of the skin tissue 280. Thus, the bottom surface 520 of the device 500 is substantially flat and/or it can be contoured along the skin surface 27A in the region of the skin tissue 280 that can receive optical radiation. The bottom surface 52 of the exemplary device 500 can be relatively thick (eg, after Side wall 510) such that it exhibits a thermonal mass. Thick bottom surface 520 has 200938247 to help protect skin surface 27. Protect from unwanted heat damage (when filament i2 is oxidized or otherwise reacted to produce light radiation) The heat emitted by the filament 12 is otherwise induced. For example, the entire device can be cooled (for example, by placing it in a refrigerator) before being applied to the skin surface 27 〇〇 (including the equal surface 520) to further help avoid the above-mentioned unwanted thermal damage. When in contact with the Table® 270, the cooling bottom &amp; 52〇 also promotes cooling of the skin tissue 280, which also promotes reduction and / or to exclude pain associated with exposure of skin tissue 280 to light radiation. Portions of sidewall 510 (eg, its outer surface) may be provided with a reflective coating or layer 515. As described herein, reflective coating 515 described above may be The energy released by the combustion or reaction of more filaments 120 is directed toward the skin tissue 280 to be treated, so it is possible to utilize more of the available energy to illuminate the skin tissue 280. In certain exemplary embodiments of the invention, certain The material or additive forms and/or coats the bottom surface 520, and certain materials or additives may act as tears to partially or completely block light at certain wavelengths or wavelength ranges produced by the filament 120' thereby reducing and/or avoiding At least a portion of the radiation having a specific wavelength passes through the bottom surface 520 and enters the skin tissue 280. Similarly, the sealing member 11 of the burning lamp 1A shown in FIG. 1 can also utilize the light having the above-mentioned light. The properties of the material are formed. The advantages of the filtering described above are described herein. Yet another exemplary device 54 in accordance with further embodiments of the present invention is shown in Figure 5B. The exemplary device 540 is substantially similar to that shown in Figure 5a. Apparatus 500. The exemplary apparatus 540 can further provide a slit or aperture 17 200938247 550 in the bottom surface 52. A thin element can be provided in the slit 55. The thin filter 560 can be used to inhibit as described herein. Or avoiding the irradiation of light having certain wavelengths onto the tissue to be treated. The filter element may be formed from any suitable material (such as plastic, glass, colloid, etc.) having the desired light filtering characteristics. For example, by varying the type of element 56, the light characteristic (i) characteristic produced by device 54(R) on the tissue to be treated can be altered to treat different types of symptoms or features. The filter member 56 can also be a minus (four) member&apos; which primarily reduces the peak intensity and/or flux of light radiation passing therethrough and then interacting with the skin tissue 280. In a second exemplary embodiment, a plurality of slits or apertures 5 5 may be provided in device 540. This exemplary structure facilitates the use of a plurality of filter elements 56 for further modifying the spectrum of optical radiation wavelengths passing therethrough and illuminating the tissue to be treated. Alternatively or additionally, the slits 55 are wide enough to receive a plurality of filter members 560 to provide spectral modifications of the optical radiation described above. The non-standard device 5 40 can also be provided with a plate 570 on the bottom surface 5 2 , and the plate 5 70 can include one or more apertures or openings 575 therethrough. Plate 570 can be used to shield tissue under a portion of device 504 such that, for example, only tissue beneath aperture 575 is exposed to optical radiation generated by the device. Thus, a single type of device 540 can be used to provide optical radiation to a treatment location below one or more of the apertures 575 while avoiding or reducing other adjacent areas of the tissue from being illuminated. Plate 5 70 can be attached or affixed to bottom surface 520 of device 540. Alternatively or additionally, the plate 570 can be located on the surface of the tissue such that the apertures 575 are directly on a particular area of tissue that is about to be exposed to optical radiation. Device 540 is placed on a positioning plate 570 and activated as described herein to provide a pulse of light radiation through aperture 575 and onto the tissue region to be treated. A plurality of the above-described multi-purpose panels 570 having apertures 575 of different sizes may be provided to treat specific regions of tissue of different sizes and/or shapes. The above exemplary board 570 can also be applied with any of the exemplary embodiments of the invention described herein. Another exemplary apparatus 58 in accordance with still further embodiments of the present invention is not shown in Figure 5C. The exemplary device 580 is also substantially similar to the device 500 shown in Figure 5A. The bottom surface 52 of the device 58 can include a cavity 59. The chamber 590 can be filled with water to form a water filter that can reduce and/or eliminate the amount of infrared radiation passing therethrough as described herein. For example, an exemplary device 58() including a water filled cavity 590 can be stored in the refrigerator. When the device is placed completely on the tissue to be treated and the optical radiation pulse is generated by activating the combustible material 120, the east water layer provides both infrared and tissue cooling. Other materials or mixtures having specific radiant properties may also be provided in chamber 590. The above materials or mixtures may be in the form of a solid, a liquid or a gas. _ The exemplary device 500, 540, 580 (which may not include a separate cover) shown in Figures 5A-5C is particularly simple and/or comparable to some of the other features provided in accordance with the further exemplary embodiments of the present invention. Made cheap. According to an exemplary embodiment of the invention, combustion lamps having different characteristics may be applied - the characteristics associated with the particular burner lamp to be applied include, as described herein, which may be based on the particular treatment to be provided and/or to be treated Choose from specific defects or symptoms. For example, many photography 19 200938247 Characteristics of flash bulbs (including such as pulse period, total output (lumens-seconds) and peak intensity (lumen)) are described in W.D. M〇rgan, Synen) fiash

Photography, Morgan &amp; Lester, New York, NY (1939) 39-54. Based on the structure of the conventional flash bulb described above, the burner lamp can be easily retrofitted, constructed or modified to have certain exemplary features suitable for a particular phototherapy application. For example, an exemplary pulse period for some applications may be between about 5 milliseconds and about 2 milliseconds or, for example, about 100 milliseconds or longer (if desired). Other pulse periods can also be provided, such as pulse widths of up to about 1 second. The pulse period provided by a particular burner is based on the width or thickness of the filament W (such as a wire or swash) provided by the burner. In general, for example, a thicker filament can result in a larger pulse width because it can maintain a longer reaction time in the combustion lamp 100. The pulse width is also affected by the amount of oxygen provided in the particular material and/or enclosure 11 诸如 used to form the filament uo.

Some of the conventional combustion crucibles described herein may have defects. The color of the above-mentioned lamp in the form of light provided by the light can thus include a range of wavelengths in the visible spectrum. As described herein, different exemplary filter arrangements can be selectively utilized to facilitate the luminescence of only certain burner lamps: the skin length illuminates the skin. The above wavelengths can be selected based on a number of factors, such as the tissue or defect to be treated, the usual pigment level of the patient's skin tissue, and the like. The specific flux of the applied radiation can be determined based on a number of parameters. For example, a target area of 28 皮肤 of the skin tissue can be modified by changing the amount of filament 120 supplied by the burner lamp 20 200938247 to comminute the combustion 帛 1 〇〇 and/or other exemplary device configurations described herein. Total amount of radiation. For example, a larger enclosure 110 can facilitate the supply of a relatively large amount of filaments 12() in the single-fire (10) (10). A plurality of burner lamps 100 can be provided in the single-outer cover 220, which can also provide a larger flux from the fine-grained magnetic oorv "υ I' knife ^ 赝 structure 280 under the outer cover 220.

Different combustion lamps or enclosure geometry including flammable filaments 120 or other reactive materials can also be used for a particular application. For example, a wider enclosure shown in the 5a_5 diagram can be applied instead of the sphere shape as shown in the combustion lamp ι of the i-th diagram. The height of the above exemplary enclosure can be selected to provide a desired amount of filament 12 to cover the various unit areas of the tissue beneath the device to achieve a particular flux. It is also possible to change the size and shape of the above device from the top. ❹ 'Combustion lamp 1 〇〇 or enclosure ιι〇 can be configured to have a small width and a fairly wide base (for example, a thin disk-like shape) that provides a relatively small amount of filament (and correspondingly smaller radiant flux) Amount) covers a large area of tissue. Alternatively or additionally, a higher enclosure having a smaller base can be used to provide a higher flux to apply a stronger pulse of optical radiation to a particular tissue region. For example, a closure or a device with a higher closure (eg, a height greater than about 2 cm) can provide more filaments 12〇 covering the various unit areas of the tissue, which can produce greater light radiation when activated. Flux. Conversely, an enclosure having a low profile (e.g., having a height of about 1 cm or less) can only provide a small amount of flammable or reactive filaments 120 covering the various unit areas of the tissue. The low profile lamp or enclosure described above produces less light radiant flux to illuminate the underlying tissue. Some of the factors that can affect the radiant flux of light that illuminate the skin. 200938247 Factors include the enclosed strain, &amp; the geometry of the firmware bulb and/or equipment, the flammable/reactive material 枓 and the imminent travel + A, the distance between the treated tissues The amount of reactivity provided therein: the amount of radiation that can be directed to the tissue toward the tissue: any transition between the burner and the tissue. The above indications can be considered to produce an appropriate flux level for a particular phototherapy application. ❹

The exemplary flux values for the same/alpha therapy or skin treatment are typically selected from, for example, between about 200 W, or preferably between about 10 J^ and about 30 J/em2, or more preferably about 1 J/em2. Between approximately 15 J/cm2. The above exemplary flux ranges can produce different amounts of heating and/or thermal damage in the skin surface 27 and/or skin tissue 280. Certain exemplary embodiments of the invention may include a strap, an adhesive, or another fastener that can be used to secure the outer surface of the skin tissue 280 to be treated. The button 240 and the activation arrangement 23A are selectively provided separately from the outer cover 22 and the combustion lamp (10). For example, the activation arrangement 23〇 and the switch 24〇 may be provided at a distance from the outer cover 22〇 and may be provided by, for example, a wire or the like connected to the combustion lamp 1 (eg, electrically connected to the initiator 150). . Alternatively or additionally, the activation arrangement 23A may be fixed to the outer cover 220, and the switch 240 may be provided at a distance from the activation arrangement 23A and connected by, for example, a metal wire or the like. Exemplary embodiments of the present invention can be used, for example, to treat a number of deficiencies and provide a number of treatments for skin tissue, which can include illuminating tissue with optical energy or other electromagnetic radiation. As described herein, the burner light can be selected or designed to provide the desired amount and type of radiation to be treated. The above parameters (such as the size of the burner (e.g., the number of filaments 120 included in 22 200938247), the size and shape of the outer cover 220, and the selective application of the filter arrangement 250 can be readily determined using calculations or a few measurements. The changes in the t Α 扣 扣 以 以 以 以 以 以 以 以 。 。 。 。 。 。 。 。 。 。 。 The invention described herein can be utilized; in the treatment of different pigmented and/or venous lesions and other by the u, the sacred month, and other symptoms and defects by the imaginary genus &amp; Examples of such skin conditions and deficiencies include, but are not limited to, sputum, acne, wine stains, hemangioma, spider reticular vessels, unwanted hair removal, φ photodynamic therapy, Wrinkle removal and collagen contraction. The optical radiation provided by the exemplary embodiments of the invention described herein may also be combined with different materials to provide a more effective treatment for certain symptoms. For example, a chromophore can be applied to certain portions of the tissue to be treated to enhance absorption of optical radiation. The above luminophores include carbon particles such as those provided in solution or markers or any other common luminophore used in phototherapy applications. The photosensitizer can also be used in conjunction with embodiments of the invention to enhance the effect of light radiation on the tissue. The above photosensitizers can be used, for example, in photodynamic therapy treatments. Lidocaine gum or solution can also be applied to the tissue to help reduce y pain perception and act as a photosensitizer. In certain exemplary embodiments, lidocaine gum may be provided on the lower surface of the outer cover or closure so that the glue contacts the tissue surface when the treatment device is placed on the tissue. Other common photosensitizers can also be used in conjunction with the optical radiation produced by the exemplary systems and devices described herein. Some specific embodiments of the treatment are detailed in detail. For example, the embodiment of the present invention can be used in a number of applications that typically employ relatively few pulses of radiation 23 200938247. Example 1 Figure 6A shows a photograph of a raised cherry hemangioma (measured about 5 mm wide) for treating a hemangiomas according to certain exemplary embodiments of the present invention, by exposing the blood tumor to a single unit such as an M3 photographic flash bulb The optical radiation pulse provides a reflective arrangement at the burning lamp circumference gj and does not apply a light light emitter. Rad Provides radiation through pores located on cherry hemangiomas. The amount of radiation applied is '9-10 j/cm2' and the total energy provided by a single pulse is about 4 J. The pulse period is about 10-15 milliseconds. Several initial blackening and hardening treatments of hemangiomas were found in the first week. The appearance of the aneurysm after about six weeks was shown in the photograph of Figure 6b, taken at the same magnification as the photograph shown in Figure 6A. It appears that the appearance of this defect is significantly improved, and the hemangioma is generally lighter and smaller in size. If desired, the second pulse should be used to further improve the appearance. In the photograph of Figure 6B, there are some residual injuries to the healthy tissue surrounding the tumor. The above undesirable effects can be reduced, for example, by providing an ultraviolet light-emitting member as described herein, reducing the flux of the applied light radiation pulse, or a combination of these changes. Figure 7A shows a normal (flat) hemangiomas (straight uim) m slices. The hemangioma is exposed to, for example, sputum according to an exemplary method of the invention; a single-pulse balance of unfiltered light radiation provided by a photographic flash bulb. A reflective arrangement can be provided around the burner lamp and radiated through the pores located on the hemangioma. The flux of the applied radiation is about 9_1 (W/em2, while the total energy provided in a single pulse is about 4-15 pulse periods of about 10-15 milliseconds. During the first week, several direct processes of hemangiomas and blackening and blood vessels are found. Some of the tumors became hard. The appearance of the aneurysm after treatment for about six weeks is shown in the photograph of Figure 7B. The hemangioma appears to be significantly lighter and smaller. In the photograph of Figure 7B, there is a small amount of damage to the skin around the hemangioma. This can be reduced, for example, by providing a UV filter to pulse the radiation and/or to slightly reduce the applied flux. t Example 3 According to an exemplary embodiment of the invention, the brown color shown in the photograph of Figure 8A is shown. Old age spots (freckles) (measured approximately 3 mm wide) are treated with, for example, a single pulse of light radiation. Unfiltered radiation is provided by an M3 flash bulb placed in a reflective enclosure. The aperture is placed on the freckles. The overall flux is about 9-10 J/cm2, and the applied energy is about 4 j. The pulse period is about 1 〇 15 milliseconds. Some initial changes in freckles are found, and the freckles appear black on the first day. Fading in a week. Treatment about six The appearance of the freckles is shown in the photograph of Figure 8B. Although the grayscale image of Figure 8A is not obvious, the brown appearance of the freckles shown in the photograph of Figure 8A is significantly reduced, while the deeper area is in Figure 8B. The appearance in the photograph is light red. Therefore, the pigmentation enhancement of freckles can be reduced by this treatment. The dark area shown in Fig. 8A indicates some skin tissue damage associated with the illumination of the pigmented lesion itself. Reducing the above-mentioned accessory damage, for example, by providing an infrared filter to pulse the optical radiation and/or reducing the flux applied to the pulse of the above-mentioned age spots by 25 200938247. It is therefore understood that those skilled in the art can design various embodiments of the invention. The system, the arrangement and the method are not intended to be shown or described herein, but are intended to be within the spirit and scope of the present invention. In addition, all publications, patents, and patent applications mentioned herein are hereby incorporated by reference in their entirety. [Simplified Explanation of the 囷] In order to more fully understand the present invention and its advantages, reference is now made to the above and accompanying drawings, in which: 1 is an illustration of an exemplary combustion lamp applied in accordance with an exemplary embodiment of the present invention; FIG. 2 is an illustration of an exemplary apparatus for providing optical energy to a tissue in accordance with an exemplary embodiment of the present invention; Exemplary embodiments provide an illustration of further exemplary apparatus for optical energy to tissue; FIG. 4 is an illustration of yet another exemplary apparatus for providing optical energy to tissue in accordance with certain exemplary embodiments of the present invention; FIG. 5A is in accordance with the present invention A particular exemplary embodiment provides an illustration of an exemplary apparatus for optical radiation to tissue; FIG. 5B is an illustration of another exemplary apparatus for providing optical quantities to skin tissue in accordance with further exemplary embodiments of the present invention; 26 200938247 The further exemplary embodiment provides an illustration of another exemplary apparatus for optically imparting to skin I and weaving; Figure 6A is a protuberance of cherry-colored blood sputum; Figure 2 is a single-optical radiation according to an exemplary embodiment of the invention. The pulse A picture shows that the cherry color is also an image of the tumor, for example, after 6 weeks; the 7A picture is a demonstration image of the flat hemangioma;

Fig. 7B is an image of a hemangiomas displayed by a single light pulse pulse '&lt;,, Fig. 7A, for example, after 6 weeks, according to an exemplary embodiment of the present invention; Fig. 8A is an exemplary image of a color senile plaque (freckles) And, 8B® illuminates the image of the age spots shown in FIG. 8A, for example, after 6 weeks, in a single optical energy pulse according to an exemplary embodiment of the present invention. The same element numbers and symbols are used to represent similar features, elements, components or parts of the described embodiments, unless otherwise indicated. Further, although the present invention will now be described in detail with reference to the accompanying drawings, FIG.

[Main component symbol description] 100 Burning lamp 110 Enclosure 120 Filament 130 Cover 140 Contact 150 Initiator 200, 300, 400, 500, 540, 580 Equipment 220 Cover 230 Activation arrangement 240 Button 250 ' 560 澹10 27 200938247 270 Surface 280 Skin Tissue 510 Sidewall 515 Reflective Coating 520 Bottom 550 Slit 570 Plate 575 Pore 590 Cavity 〇 28

Claims (1)

200938247 VII. Scope of application: 1. A device for illuminating radiation to at least one biological tissue, comprising at least: • a Koda ray arrangement arranged to generate the radiation according to a chemical reaction; and wherein the optical radiation is at least At least a portion of a biological tissue produces a biological effect. Φ 2. The apparatus of claim i, wherein the radiation arrangement comprises a combustion lamp. 3. The apparatus of claim 2, wherein the radiation arrangement comprises a sealed enclosure and a combustible material provided in the seal of the seal. 〇: As for Jinshen, please refer to the equipment mentioned in item 3 of the patent scope 'where the combustible material package is 5. If the application mentioned in item 4 of the patent application scope is ambiguous, the metal includes aluminum. At least one of a sea-based aluminum (hydronalium) or an aluminum alloy. 6. The apparatus of any of claims 3-5, wherein the combustible material is provided in the form of one of a metal wire. S 29 200938247 7 • Any of the items 3-5 of the patent application – combustible materials are supplied in one form of a foil. The apparatus described in the above, wherein the apparatus of claim 3, wherein the radiant arrangement of the apparatus further comprises a gas provided in the seal of the seal comprising about 8〇% About i 〇〇% of anhydrous oxygen, which is the gas 9. A trigger for the initiation of the chemical reaction, as set forth in claim _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ The apparatus of the present invention further includes the apparatus of claim 9, wherein the apparatus of claim 9 includes at least one of a battery or a piezoelectric crystal. Wherein the driving energy source ❹ 11· the apparatus of any one of the claims of claim 9 and/or the lance 1 wherein the light illuminating arrangement further comprises - igniting in the sealed enclosure Arranged, and wherein the triggering arrangement is configured to provide the drive energy to the ignition arrangement to initiate the chemical reaction in the sealed enclosure. 12. Apparatus according to any of the preceding claims, further comprising - an optical arrangement for directing at least a portion of the light transition toward the at least one biological tissue. 30 200938247 13. The apparatus of claim 12, comprising a reflective surface. The apparatus of claim 13, wherein the apparatus of claim 13 includes a reflective layer provided on at least one of the at least one of the radiation arrangements. Where the reflective surface portion is above or in the middle portion 15. A cover is provided as in the patent application, and is disposed in a radiating arrangement. The apparatus of any of the preceding claims, further comprising a predetermined distance away from the tissue or placed. 16. A portion of the apparatus of claim 15 includes a reflective surface. 'The outer cover of the cover 17. The scope of the invention is set forth in any one of the preceding claims, wherein the radiation source is provided in the form of a pulse. 18. As claimed in claim 17 of the invention, wherein the period of the at least one pulse is between about 5 milliseconds and about 2 milliseconds. 19. The object of claim 17 is further provided, wherein the period of the at least one pulse is between about 10 milliseconds and about 1 millisecond. 20. The device of claim 3, wherein the at least one pulse 31 200938247 comprises a cycle of about 10 milliseconds and about s. Between milliseconds. ‘=If you apply for a patent range... The rib of any of the items is for at least one of the optical radiation on the tissue, between 1 J/crn 2 and about 3 〇 J/cm 2 . V, - flux is about = = = _17, any item mentioned in the item... © k is used in the organization for at least one 〆, 1 J/cm 2 and about 15 J/cm 2 of the light . </ RTI> </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> The package is less - a filter arrangement between the biological tissues to avoid the light radiation having a specific wave less on a biological tissue. The apparatus of claim 23 includes an ultraviolet filter. Wherein the filter arrangement is as described in claim 4, wherein the ultraviolet filter element is arranged to prevent at least a portion of the optical radiation having a wavelength of less than about 55 〇 (10) from being irradiated to the at least one biological tissue. on. 26. The apparatus of claim 23, wherein the filter arrangement comprises an infrared filter. The apparatus of claim 1, wherein the infrared filter system is configured to prevent at least a portion of the wavelength of the phosphorescent light from being greater than about 1100 nm from illuminating the at least one of the 4^^ biological tissues on. 28. The apparatus of any of the preceding claims, wherein the infrared filter comprises a water filter. 29) As described in claim 28, wherein the water filter comprises -. A seal of water 3 is provided between the radiation arrangement and the at least one biological tissue. The device of claim 29, wherein the water is disposed to be cold bundled and placed in thermal contact with at least a portion of a biological tissue when the axial arrangement produces the optical radiation. The apparatus of claim 23, wherein the filter element is configured to prevent at least μ of the wavelength of the radiation of the material from being irradiated onto the at least one biological tissue in the visible spectrum. The apparatus of claim 1 wherein the filter arrangement and the radiation arrangement are provided as a single ', early component, as claimed in any one of the claims. 33. The apparatus of any of the claims of claim 23, wherein the apparatus comprises a plurality of filter arrangements. The apparatus of any of claims 33, further comprising a mask comprising at least one aperture extending therethrough, wherein the mask is configured to prevent the light radiation from illuminating the at least one At least part of the biological tissue. The apparatus of any one of claims 1 to 34, wherein a portion of the light ray is configured to be absorbed by at least one pigmented lesion of the at least biological tissue . The device of any one of claims 1 to 3, wherein a portion of the optical radiation is configured to be absorbed by at least one venous lesion of the at least biological tissue. The device of any of claims 1 to 34, wherein a portion of the optical radiation is configured to be absorbed by at least one hair follicle located in the at least one biological tissue. The device of any of claims 1 to 34, wherein a portion of the optical radiation is configured to be absorbed by at least one chromophore applied to at least a portion of the tissue. 39. The device of any of claims 1 to 34, wherein 34 200938247 a portion of the optical radiation is configured to be absorbed by at least one photosensitizer applied to at least a portion of the tissue. 35