TW200845902A - Composition for controlling external parasites and method therefor - Google Patents

Abstract

This invention provides a composition for controlling external parasites having an excellent optical stability and being capable of suppressing a decomposition of effective ingredients caused by light, and a method therefor by using such a composition. The composition of this invention is characterized in containing an ethoxazole as an effective ingredient, an UV absorbent and a phenolic anti-oxidizing agent. By a combination of a UV absorbent and a phenolic anti-oxidizing agent, a significant synergistic effect is obtained. The ethoxazole, UV absorbent, and the phenolic anti-oxydizing agent are mixed in the mass ratio of the range of 1: 0. 05 to 5: 0. 005 to 5, in the order of ethoxazole, UV absorbent, and phenolic anti-oxidizing agent.

Description

200845902 / IX. DESCRIPTION OF THE INVENTION: TECHNICAL FIELD The present invention relates to an external parasite repellent composition and an external parasite repelling method. More specifically, the present invention relates to an external parasite repellent composition for enhancing light stability and an external parasite repelling method using the same. [Prior Art] Long-ethyloxazole ((RS)-5·t-butyl-2-[2-(2,6-difluorophenyl)_4,5_di-虱-1,3-喔Sal] 4_yl]phenethyl (10)) is known to be useful for insecticidal and smoldering agents (Table Illustrated. Japanese Patent No. 3, No. 5; Patent Document) and Japanese Patent No. Μ 747 唬, Patent Document 2), in addition, Use of an external parasite of an animal and a control agent for a single-feeding cockroach (refer to Japanese Patent Publication No. 2〇〇〇5〇丨695; Patent Document 3). However, the σ oxazoline compound is outdoors. In the case of use, the selection of the light stabilizer is important because of the lack of light stability. § In the patent publication No. 9_59115 (Patent Document 4), the optical stability of the compound is described. It is true that the ultraviolet acrylate vinegar, the benzoic acid sulfonate or the benzophenone ketone ultraviolet light absorber can be used alone or in combination, and the light stability is also fully obtained by thermal method. In addition, there are also 2, 2 in combination. ',4,4'-Tetrahydroxydiphenyl fluorenone and 2,6_di-second butyl-4_(4,6-bis(octyl sulphide*H,3,5-trioxan-2-ylamino) The method of smashing the light Japanese Patent Laid-Open Publication No. 2002-146/4; Patent Document 5), which relates to the inhibition of the decomposition of pyrethroid extract, is not related to the sputum-based compound. In addition, the system is used in combination. UV light absorption 319273 5 200845902 :d and anti-oxidant can not fully inhibit the photolysis of the active ingredients of pesticides. The half-only effect can be added. It is said that sometimes the anti-effect is also reduced to reduce the effect. 曰本专利第389011 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 Patent Document 3 Patent Document 4 Patent Document 5 [Problem to be Solved by the Invention] An object of the present invention is to provide a composition of an animal repellent excellent in light stability and use of the composition* (Solution of the problem) Method) M can be used for insect repellent method. The researcher of the present invention focused on the stability of the light of B-side wow, and found that the carbazole was absorbed by the ultraviolet light absorber. "(10) 糸 糸 糸 糸 组合 颂 颂 颂 颂 颂 颂 颂 颂 颂 颂 颂 颂 颂 颂 颂 颂 颂 颂 颂 颂 颂 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 Compared with the single use: the stability effect, the solution, and the discovery and non-destructive and the high residual effect of the external light knife to complete the invention. The effect of the spider, and it is shown that the present invention is The invention of the external parasite repelling method for repelling the composition by the following external parasites, and the use of the 319273 6 200845902 'b material:=: the parasite parasitic repellent group Qin 2 component, and containing ultraviolet light absorption fine system Antioxidant, 2. Lishen 1 is not only, machine emulsifier 0 ultraviolet light absorber is selected from the insect repellent composition, wherein, the above is characterized by "selected from the following compounds and used one or two The general formula (1) - 乂 ^ / the next ketone compound, R3

(I) (wherein R1 represents a hydrogen atom, a linear or branched alkyl group having a carbon number of 丨 to 12, a benzene group (1), and (CH2)4-Ο

(1) R2 represents a hydrogen primordium, a repeating acid group or a group represented by the formula (2), H3C0

(2) R3 is not a hydrogen atom or a hydroxyl group, R4 is a hydrogen atom, a hydroxyl group or a decyloxy group, and a cyanoacrylate compound represented by the general formula (II), 7 319273 200845902 σ', COORe (Π) I branch chain alkyl. (wherein R 1 2 represents a straight bond having a carbon number of 1 to 8; a benzotriazole compound represented by the general formula (ΙΠ), HO R3

(III) R9 (wherein R3 represents a hydrogen atom, a carbon number, a burnt group to a chain, an α,α,··^methylbenzyl group, or a formula (3)=having a straight chain or a branching group W -CN H2, C II shows the base shown by (3) or (4),

319273 8 1 2 R4 represents a hydrogen atom or a succinct test. R8 is a linear or branched chain alkyl, methoxy, α,α, dimethyl dimethyl decyl propylene oxy group, R9 Hydrogen atom or chlorine atom), soil 200845902: a salicylic acid compound represented by the general formula

(IV) C-0 II 0 Oxygen atom, or a linear or branched carbon number of 1 to 8 (wherein the alkyl group of the R10 chain). (3) The phenolic antioxidants contained in the above-mentioned items are ή + ή 、 、 、 、 、 、 、 、 、 , , , , y y y y y y y y y y y y y y y y y y y y y y y y y y y y y In the polyphenol-based compound, the compound from the top is used as a feature.

(V) (wherein R11 represents a hydrogen atom, an isopropyl group, a chloromethyl group, a tert-butyl group, a benzyl group, a 4-mercaptophenyl fluorenyl group or a methacrylate group, and R12 represents a hydrogen atom or a Dibutyl, R13 represents a hydrogen atom, a mercapto group, an ethyl group, a methoxy group, an isooctylpropionate group or a stearyl propionate group, R14 represents a hydrogen atom or a fluorenyl group, and Rl5 represents a hydrogen atom or a carbon number. a linear or branched chain of 1 to 5, (1) 2,2'-arylene di(4-mercapto-6-tert-butylphenol), (2) 2,2 , anthracenyl bis(4_ethyl-6-tert-butylphenol), (3) 4,4'-thiobis(3-mercapto-6-tert-butylphenol), (4) 4 ,4,·Butylene bis(3-indolyl-6-t-butylphenol), 9 319273 200845902 " (5) 3,9-bis[1,1·dimethyl-(3-third 4--4-hydroxy-5-methylphenyl)propoxy]ethyl]_2,4,8, tetrasigmine snail [5,5] eleven, (6) 2,2-thiodivinyl Bis[3-(3,5-di-t-butyl-4-yl-hydroxyphenyl)propionate], (7) triethylene glycol bis[3-(3-t-butyl-4-hydroxy-5) -tolyl)propionate], (8) 1,6-hexanediol bis[3-(3,5-di-t-butyl-4-hydroxyphenyl)propionate], ♦ (9)1 ,1 3·3(2_fluorenylhydroxy_5_t-butylphenyl)butane, (10) 1,3,5-trimethyl-2,4,6-tris (3,5-di third Butyl-4(hydroxybenzyl)benzene, (U)tetrakis[-indenyl-3-(3,5-di-t-butyl-4-hydroxyphenyl)propionate] decane, (12) Bis(3,5-di-dibutyl-4-hydroxybenzyl)isocyanurate, or (13)bis[3,3^bis·(4'-hydroxy-3,_t-butyl) Phenyl) butyrate] ethylene glycol ester. 4. The composition of the external parasite repellent according to any one of the above 1 to 3, wherein the ratio of the ratio of the oxazole, the ultraviolet light absorber, and the phenolic antioxidant is expressed by mass ratio: 〇〇5 to 5: 〇.〇5: 5. An external parasite repelling method characterized by using the external parasite repellent composition according to any one of the above items. (Effect of the Invention) The composition of the external parasite repellent of the animal of the present invention can be inhibited by the effect of the synergistic light stabilization of 319273 10 200845902 by the ultraviolet light absorber (IV) of the component. The decomposition of acetylcarbazole. Further, the external light absorber and the phenolic antioxidant are used together, and the effect of external parasites is not affected. Therefore, the composition is used in an animal, and the effective parasitic repellency effect can be sustained for a long period of time, and the residual effect is also remarkably improved, and the effect is more remarkable when the shackle is used outdoors in sunlight or the like. Animal external parasite repellents are extremely useful. (Embodiment) (Best Mode for Carrying Out the Invention) The external parasite repellent composition m of the present invention is an active ingredient and contains an ultraviolet light absorber and an i-type antioxidant as a photostabilizer. Preferably, the ultraviolet light absorbing agent is selected from the following compounds: a benzophenone compound represented by the general formula (I);

a cyanoacrylate compound of the general formula (II);

a benzotrisal compound represented by the general formula (III); 319273 11 200845902 HO r6

(HI)

Or the general formula (IV) of the salicylic acid compound OH

(IV) r°O-Rl The antioxidant of the test system is preferably selected from the general formula (dry single compound and double test compound or multi-type compound 2: early age chemical compound. 1 or 2 Above 13 .

(V) In the present invention, it is preferred to use one or more kinds of the above-mentioned k-ketone compound (I), the stone π* ►π human/mercapto acrylate compound (II), benzobisazole Compound (III) and water-sucking seed or two or more kinds of white light (IV) ultraviolet light absorber, and 1 ^ cabin intervening 4 ^ the above monophenolic compound (V) and bisphenol-based ultraviolet light absorption In the agent, the hydrogen atom, the diphenyl group represented by the formula (1), and the homologous heart A, ^ ^ AA number of 1 to 12 have a straight or branched chain; Base or formula (υ 319 319273 12 200845902 (CH2) 4—Ο

R2 represents a hydrogen atom, a sulfonic acid group, or a group represented by the formula (2),

R3 represents a hydrogen atom or a hydroxyl group, and R4 represents a hydrogen atom, a hydroxyl group or a decyloxy group. In the above cyanoacrylate compound represented by the general formula (II), R5 represents a linear or branched chain alkyl group having an anisotropy of from 1 to 8. In the benzotriazole compound represented by the above formula (III), R6 represents a hydrogen atom, a linear or branched alkyl group having a ash number of 1 to 5, and an α,α,-dimercaptomethyl group. , the base shown in formula (3),

13 319273 (4) 200845902

OH

Ch3 R7 is not a hydrogen atom or an octyloxy group, R8 represents a hydrogen atom, a linear or branched chain material of a stove, a methoxy group, a methyl methoxy group of: - 8 to 8, a chlorine atom or a chlorine atom atom. ’

In the salicylic acid-based compound represented by the above formula (iv), the linear or branched chain H of the r1〇 or carbon (4) 1 to 8 is a compound of the above formula (v). The compound is not a hydrogen atom, an isopropyl group, a chloromethyl group, a tert-butyl group, a benzoinyl group, a 4-fluorenyl group, a methyl group, or a methyl acrylate group, and R12 represents a hydrogen atom or a tert-butyl group. R13 represents a hydrogen atom, a methyl group, an ethyl group, a decyloxy group, an isooctylpropionic acid aryl group or a stearyl propionate group, and Ri4 represents a hydrogen atom or a fluorenyl group, and r]5 represents a hydrogen atom or a carbon number of 1 A linear or branched alkyl group of up to 5. Specific examples of the above-mentioned double-test compound or poly-try compound are as follows: (1) 2,2'-methylenebis(4-fluorenyl-6_t-butylphenol), (2) 2,2'· Methylene bis(4-ethyl-6-tert-butylphenol), (3) 4,4'-thiobis(3-methyl-6-t-butylphenol), (4) 4, 4'-butylidene bis(3_mercapto-6-tert-butylphenol), (5)3,9-bis[1,1_-indenyl_2-[/5-(3-t-butyl) 4--4-yl-5-tolyl)propanooxy]ethyl]-2,4,8,10-tetraspiro[5,5]undecane, 14 319273 200845902 - (6)2, 2-thiodivinylbis[3_(3,5-di-t-butyl-4-hydroxyphenyl)propionate], (7) triethylene glycol bis[3-(3-t-butyl) -4-hydroxy-5-tolylpropionate], (8) 1,6-hexanediol bis[3_(3,5-di-t-butyl-4-ylhydroxyphenyl)propionate], (9) 1,1,3-bis(2-indolyl-4-ylyl-5-dibutylphenyl)butane-(10) 1,3,5-trimethyl-2,4, 6-tris(3,5-di-t-butyl-4-hydroxyphenylindenyl)benzene, (11) tetra-[indenyl-3-(3,5-di-t-butyl-4-hydroxyl) Phenyl)propionate]曱, (12) Tris(3,5-di-t-butyl-4-hydroxybenzyl)isocyanuric acid , or (13) bis [3,3'-bis-(4,-hydroxy-3'-t-butylphenyl)butanoic acid] ethylene glycol ester, etc. The specific compounds of the ultraviolet light absorber are as follows: Methyl ketone compound: Compound 1: 2,4-dihydroxybenzophenone, compound 2: 2-hydroxy-4-indolyldibenzophenone, compound 3: 2-hydroxy-4-octyloxydiphenyl Anthrone, Compound 4: 2-Hydroxygastrid 4-dodecyloxybenzophenone, Compound 5: 2,2, Dihydroxy-4-decyloxybenzophenone, Compound 6: 2,2,- Dihydroxy-4,4'-didecyloxybenzophenone, compound 7: 2-hydroxy-4-decyloxybenzophenone-5-sulfonic acid·3 hydrate, compound 8: 4-benzoic acid Oxy-2-hydroxybenzophenone, 15 319273 200845902 , compound 9 : 2,2'4,4, tetrahydroxydibenzophenone, · compound 10 : 1,4-bis(4-benzoinyl- 3-Hydroxyphenoxy)butane, compound 11: bis(2-methoxy-4-hydroxy-5-benzomercaptophenyl)decane. Cyanoacrylate compound: Compound 12: 2-ethylhexyl-2-cyano-3,3,-diphenylacrylate, compound 13 ·Ethyl-2-oxy-3,3'-diphenyl Acrylic acid vinegar, benzotriazine compound: compound 14 ·· 2_(2_hydroxy-5-fluorenylphenyl)-2H-benzotriazole, _compound 15 : 2-(2-amino-5 -T-butylphenyl)-2H-benzotrien. Sit, Compound 16: 2-(2-hydroxy-3,5-di-tert-butylphenyl pH-benzotriazole, Compound 17: 5-Chloro-2-(2•hydroxy-3-t-butyl) _5_tolyl)-2H-benzo sine, compound 18: 5-chloro-2-(2-hydroxy-3,5-di-t-butylphenyl)-2 fluorene-benzo-one, compound 19 : 2-(2-hydroxy-3,5-di-t-pentylphenyl)_2H-benzotriazole, •Compound 20 · 2-(2H-benzotrisin-2-yl)_4_fluorenyl winter (ίο tetrahydrofuranylidene iminomethyl), compound 21 · 2,2'-methylenebis-[4_(ΐ,ι,3,3·tetramethylbutyl)-6_(2U-ben And 嗤-2 -yl), Compound 22: 2-(2-hydroxy-4-octyloxyphenyl)_2H-benzotriazole, Compound 23: 2-(2-hydroxy-5-third Octylphenyl)-2Η-benzotriazole, compound 24 · 2-(2·hydroxy-5-mercaptopropenyloxyphenyl)-2-indole-3-benzotrizine 5 319273 16 200845902 : Compound 25.2- [2-Hydroxy-3,5-bis(indole, "-di-decylphenylmethyl)phenyl]_2H-benzotriazole. Salicylic acid-based compound · Compound 26: Phenyl salicylate, Compound 27: p-tert-butylphenyl salicylate, compound 28: p-octylphenyl Among them, 2-hydroxy-4-decyloxybenzophenone of the compound 2 is preferred. Examples of the phenolic antioxidant include the following compounds: _Compound A: 2-isopropyl-5-A Phenolic (also known as thymol), Compound B: 2,6-diisopropyl-4-nonylphenol, Compound C · 2-Benzyl-4,6-diindole, Compound D: 2 -Chloromethyl-4,6-diindenyl, Compound E: 2-(4-mercaptophenyl)-4,6-dinonylphenol, Compound F: methyl-3-(2-hydroxyl _5_decyloxyphenyl) acrylate, compound G · methyl 3-(2-transyl-3,5-dimercaptophenyl) acrylate, _ compound H: methyl · 3- (2-hydroxy-3-t-butyl-5-nonyloxyphenyl)propene, acid ester, compound I: 2,6-di-t-butyl-4-nonylphenol, compound J: 2,6 -Di-tert-butyl-4-ethylphenol, compound hydrazine: 2-tert-butyl-4-methoxyphenol and 3-tert-butyl-4-decyloxy compound, compound L: hard Fatty-3-(3,5-di-t-butyl-4-hydroxyphenyl)propionate, compound Μ·hin-octyl-3-(3,5-di-t-butyl-4-predyl) Phenyl) propionate, compound N: fluorenyl bis(4-methyl-6-third Phenol), 17 319273 200845902 Compound Ο · 2,2--indenyl bis(4-ethyl-6-t-butyl-p-),, compound Ρ : 4,4,-thio-bis(3-indenyl) -6-tert-butylphenol), compound Q: 4, 4, butylene bis(3-indolyl-6-tert-butylphenol), compound R: 3,9-bis[1,1_dioxin Base_2-[call-(3-tert-butyl-4-hydroxy-5-tolyl)propoxy]ethyl]-2,4,8,10-tetraoxiro[5,5] Monoalkane, compound S: 2,2-thiodivinylbis[3-(3,5-di-t-butylbutylphenyl)propionate], compound τ: 1,1,3-tri 2-methyl-4-hydroxy-5_t-butylphenyl)butane, _compound U: 1,3,5-trimethyl-2,4,6-tris (3,5-di third Butyl-4-hydroxyphenylhydrazino)benzene, compound V: tetra-[indolyl-3-(3,5-di-t-butyl-4-hydroxyphenyl)propionate]methane, compound W: three Ethylene glycol bis[3-(3_t-butylhydroxytolyl)propionate], compound X. bis(3,5-di-t-butyl-4-hydroxyphenyl)-isocyanurate , φ compound Y: 1,6-hexanediol bis[3_(3,5-di-t-butyl-t-butanylhydroxy)propionate], compound Ζ: double [^...仏King butyl phenyl decanoate. Among them, the 2,6-di-t-butyl-4-methyl group of the compound I is preferred. In the invention, (iv) wow, ultraviolet light absorber and antimony oxidation. The ratio of blending is usually 1: 〇〇5 to 5: 〇〇5 to 5, where 1: 0.1 to 1: (U) Preferably, i is from 1: 〇a to Β 0.1 to 0.5. When the ultraviolet light absorber or (iv) any of the antioxidants 319273 18 200845902: the blending ratio is too small, it is difficult to obtain light generated by the combination. When the synergistic effect of the stabilization is small, sufficient light stabilization effect cannot be obtained. Conversely, when the ultraviolet light absorber and/or the test system antioxidant are too much, there is no economy. Further, the ratio of the ultraviolet light absorber and the phenolic antioxidant is preferably from four (4) to (10) in terms of mass ratio, and preferably from 1:5 to 2, preferably from 1:0.1 to 10. Preferably, it is 1: 〇2 to 5. The composition of the external parasite repellent of the present invention contains etoxazole and more than one kind of the characters (1) to (28), and contains the compound (VIII) to ^ More preferably, the animal of the external parasite repellent composition is a body such as a cow, a sheep, a goat, a chicken. Livestock, small animals such as dogs and cats, etc. The method of administration of the composition of the external parasite repellent, for example, direct administration, or preparation into a suitable preparation form for transdermal administration to an animal, and administration of the type product, Or applied in the environment. Transdermal administration is by, for example, dipping, L-mist: washing!; perfusion (ρ·°η), coating, drip or dusting, and irrigation, main, drip is preferred By molding the f factory mouth; ^ I in the 'by fine pieces, plates, belts, ear tags --) etc. into the environment = by dusting, graining, spreading, spraying, soil steaming or coating: etc. Among them, it is preferred to spread and spray. * Appropriate formulation form, for molded articles, such as fine chips. In addition, add liquid carrier, solid carrier or auxiliary agent, oil agent, soft agent, gel, emulsion, suspension, oil emulsification in water 319273 19 200845902 factory 制 system = medium water emulsifier, hydration颗粒 granule hydrated Qi Bu powder sword or granule

4 The form of the preparation can be used. J field liquid carrier such as water; aliphatic or alicyclic smoke, such as liquid stone, *alkane, cyclohexane, naphthalene, or smoke lamp oil; aromatic hydrocarbons such as diterpene, methylnaphthalene, two Methylnaphthalene, diisopropyl extract, silk f, ethyl hexyl benzoate, aliphatic alcohol, such as methanol, ethanol, isopropanol, 2-ethylhexanol, n-octanol, isotridecyl alcohol , alcohol, or oil aromatic alcohols, such as benzyl alcohol, phenethyl alcohol, η, 乂 虱 虱 1 ethanol; esters, two: ethyl acetate, butyl acetate, methyl laurate, tannic acid Methyl ester, Iethylhexanyl methyl ester, methyl oleate, oleic acid disperse _ field, etc.; Lai, such as methyl ethyl ketone, and hexyl butyl vinegar, such as vegetable oil, soybean oil, Saffron vegetable oil, 笠·人,斗,丄 搪/由, 撖油油 or palm oil, 50% glycerin, such as octanoic acid triglyceride, octanoic acid monosaccharide or octanoic acid/capric acid triglyceride ; B - * θ test, diethylene glycol monobutyl _, propylene glycol ^ ^ class 'such as ethylene glycol monobutyl calendar; dimethyl ethyl amine; _ 〇; team methyl · Temple, solid carrier such as natural mineral Classes, such as bentonite, talc, 'soil, attapulgite, sepiolite, acid white clay, kaolin or carbolic acid (four); or synthetic minerals, such as oxidized Ming, white stone charcoal, sulphuric acid, charcoal, sulphur Or chlorination, (cork), urea or wheat flour can be used. , 319273 20 200845902 if.. auxiliary 4 such as interface activation 胄, dispersant or wetting agent, fixation gas (flXmga state, tackifier, Lingjie stabilizer, combined sword, collapse stabilizer, etc. W Peng% agent. , surfactants, dispersants or wetting agents such as nonionic enthalpy = for example, polyoxyalkylenes, "polyoxyalkylenes", oxime, oxidized ethylene, castor oil, polyoxygenated polyoxyl , polyoxyethylene single 1. trisorbide fatty acid vinegar, bismuth tetraacetate sorbitol, mono-fatty acid glyceride, mono-half sugar alcohol two fat _, bribe vinegar, or silk sugar (four) Anionic surfactants such as sodium sulphate, sodium benzoate, "dicalcium sulphate, sulphate, naphthalene, lignin, olefins" _ salt or sulfate vinegar, polyoxyalkylene polystyrene ether phosphate or sulfate vinegar, α oleyl sulfonate, alkane bismuth citrate and other two amphoteric interfacial activators such as Ν _ _ laurel H imine Dipropionate, or lecithin, etc. = such as casein, gelatin, gum arabic, alginic acid money salt Or a mixture of Na 2 shishi anti-sweet, bentonite, or polyethylene glycol, etc. Adhesives such as xanthan gum, rhamsan gum and other heteropolysaccharides, carboxymethyl cellulose, base Cellulose or powder-killing derivatives of cellulose, hydroxyethyl starch, etc., vinyl alcohol, polyethylene mer, or mercapto vinyl ether. maleic anhydride copolymer, montmorillonite clay mineral, bentonite station Soil cations modified montmorillonite clay minerals or bentonite clay minerals, oxidized dioxide dioxide 7, or burnt-based modified smog-like sulphur dioxide, etc. 319273 21 200845902 Bonding such as B, alcohol, · Propylene glycol, or glycerin, etc. Cellulose or diterpenoids such as powder, vitamins, methylcellulose, hydroxyethyl sulphate, scorpion scorpion, or polyvinyl alcohol, etc. , stone or a different type of maleic acid copolymer, etc., ... month -, female scorpion sword such as phosphorus - field or tall oil fatty acid, etc., 夂 兴 ΜΡΑΡ ΜΡΑΡ, epoxidized soybean oil, the present invention An example of a pest in which 4 insects are effective in animals, such as a spine repellent composition. Hymenoptera pests: human cockroaches, cat mites, sturgeon pests: powder epidermis, burned epidermis. edulis, wheat flour 螨箄 >, epidermis end; long ~ civil war 媒 media; dusty meat, home meat End, straight meat, f, meat, scorpion, scorpion, fat, home, two thorns, two worms, etc. (four) spiders; (4) The composition of the external parasite repellent is percutaneously cast, and when the disc is administered by the molded product, it is suitable for the animal to weigh the weight of the animal ik. It is suitable to apply the ethazole at 250 mg/m2. Example) The external parasite repellent composition of the town (4) is exemplified by the preparation example, and the functional test and the biological test example 'Ilf _ and the ratio (4) for preventing the decomposition of B (4) are described in more detail. = clearly does not fork any of its limitations. X, "Parts" in the present preparation examples means parts by mass. 319273 22 200845902 , Formulation Example r: an oil agent dissolves 1 part by mass of oxazole, 0.25 parts by mass of the compound (2), 0.25 parts by mass of the compound I in 10 parts by mass of propylene glycol monobutyl ether, and is dissolved in 35 An oil agent is prepared in an amount of octyl triglyceride and 53.5 parts by mass of liquid paraffin. Formulation Example 2: Oily Suspending Agent: 4 parts by mass of sorbitan monooleate, 1 part by mass of polyoxyethylene sorbitan trioleate, and 91 parts by mass of liquid paraffin are uniformly dissolved, and 1 mass is obtained. Ethyl oxazole, 0.25 parts by mass of the compound (1), 0.25 parts by mass of the compound L, and 2.5 parts by mass of the cationically modified smectite-based clay mineral are stirred and dispersed, and then subjected to wet pulverization using a ball mill to prepare an oily suspension. Agent. Formulation Example 3: 5 parts by mass of ethiazole, 1 part by mass of the compound (26), 1 part by mass of the compound C, 10 parts by mass of polyoxyethylene tristyrylphenyl ether, 5 parts by mass of the emulsion The calcium dodecylbenzenesulfonate and 78 parts by mass of dinonylbenzene were mixed and dissolved to prepare an emulsion. Formulation Example 4: aqueous suspension agent 5 parts by mass of polyoxyethylene tristyrylphenyl ether phosphate, 20 parts by mass of 1% aqueous solution of xanthan gum, 1 part by mass of montmorillonite clay mineral and 67 mass The water is dispersed and dissolved, and 5 parts by mass of the acetylene bite, 1 part by mass of the compound (3), and 1 part by mass of the compound Ε are stirred and dispersed, and then subjected to wet pulverization by a ball mill to prepare an aqueous suspension. 23 319273 200845902 The effect of the decomposition of the active ingredient of the present invention and the biological effect are specifically described by the test example: GENERAL: Test Example 1: Prevention of the test of the fruit B. Various oil agents were prepared in accordance with the formulation example r as an example. Further, the preparation example 1 only removes the oil agent of the ultraviolet light absorber, and only the oil agent which is an antioxidant is removed, and the oil agent which removes the ultraviolet light absorber and the antioxidant is used as a comparative example. The prepared oil Qi Ij 200 mg was applied to a glass culture dish having a diameter of 9 cm, and placed under direct sunlight for 2 weeks and 1 month. Then, 2 ml of n-hexane was placed in a glass petri dish to dissolve the sample, and the site was injected into Sep-pak (trade name) plus siliea eanriges, and then rinsed with w-hexane to remove the effluent. Next, 15 ml of ethyl acetate was rinsed, and the effluent was collected in a Lin-shaped flask. The acetic acid was removed by steaming with a rotary steamer: = medium _ 2 ml of acetonitrile was added to dissolve. Then borrow the UV = photodetector to measure the amount of B. And the decomposition rate of the second ray is obtained by the following formula. The results are shown in Tables and Table 2. In addition, the photos (4) and the accumulation of * after the η day and after the month were found to have an increase in the multiplicative property of the ultraviolet light absorber and the oxygen stability of the oxygen. Knife solution ten (%) gas exposure Sunshine acetazol amount _ exposure to sunlight after the ethoxy oxime amount) χ 1007 exposure to the sun before the snail volume 319273 24 200845902: Table 1

Formulation Example 1 Oil Decomposition Rate (%) UV Absorber Antioxidant Addition Amount (Parts) 1 month after 1 month after Example 1 Compound (2) Compound I 0.25+0, 25 2 10 Example 2 Compound (2) Compound I 0.25+0.50 1 5 Example 3 Compounding (2) Compound I 0.10+1.00 3 6 Example 4 Compound (2) Compound I 1,00+0.10 8 15 Example 5 Compound (3) Compound K 0.25+ 0.25 8 9 Example 6 Compound (3) Compound K 0.25+0.50 3 5 Example 7 Compound (3) Compound K 0.10+1.00 4 6 Example 8 Compound (3) Compound K 1 1.00+0.10 10 18 Example 9 Compound (4) Compound A 0.25 + 0.25 8 '15 Example 1 0 Compound (8) Compound B 0.25 + 0.25 1 4 Example 1 1 Compound (1 0 > Compound D 0.25 + 0.25 2 6 Example 1 2 Compound (6) Compound G 0.25 + 0.25 1 3 Comparative Example 1 Compound (2) - 0.25 70 89 Comparative Example 2 Compound (2) - 1.0 60 80 Comparative Example 3 Compound (3) - 0.25 55 84 Comparative Example 4 Compound (3) - 1.0 53⁄4 79 Comparative Example 5 Compound (4) - 1.0 65 • 90 Comparative Example 6 Compound (8) A 1.0 53 79 Comparative Example 7 Compound (10) - 1.0 70 91 Comparative Example 8 Compound (6) - 1.0 62 84 Comparative Example 9 - Compound A 1.0 15 50 Comparative Example 1 0 - Compound B 1.0 29 55 Comparative Example 1 1 A compound D 1.0 21 48 Comparative Example 1 2 - Compound G 1.0 12 34 Comparative Example 1 3 A compound I 0.25 79 84 Comparative Example 1 4 - Compound I 1.0 7 39 Comparative Example 1 5 - Compound K 0.25 77 89 Comparative Example 1 6 A compound K 1.0 18 47 Comparative Example 1 7 One - 88 99 Accumulation of radiation: 6050kLx · hr up to 14th, 14,120kLx · hr 25 319273 200845902 / Table

Formulation Example 1 Oil Decomposition Rate (%) UV Receptor Antioxidant Addition Amount (Parts) 1 month after 1 month Example 1 3 Compound (14) Compound N 0.25+0.25 2 7 Example 1 4 Compound ( 1 5) Compound U 0.25 + 0.25 7 15 Example 1 5 Compound (1 6) Compound Y 0.25 + 0.25 10 18 Example 1 6 Compound (1 9) Compound I 0.25 + 0.25 3 5 Example 1 7 Compound (2 3 Compound R 0.25+0.25 8 9 Example 1 8 Compound (2 5) Compound Η 0,25+0.25 5 10 Example 1 9 Compound (1 2) Compound I 0.25+0.25 4 6 Example 2 0 Compound (2 7 ) Compound 0.25 0.25 + 0.25 3 8 Comparative Example 1 8 Compound (1 4) - 1.0 58 78 Comparative Example 1 9 Compound (1 5) - 1.0 61 81 Comparative Example 2 0 Compound (16) - 1.0 65 82 Comparative Example 2 1 Compound (1 9) - 1.0 66 87 Comparative Example 2 2 Compound (2 3) - 1.0 65 90 Comparative Example 2 3 Compound (2 5) - 1.0 60 85 Comparative Example 2 4 Compound (1 2) - 1.0 55 75 Comparative Example 2 5 Compound (2 7) - 1.0 62 84 Comparative Example 2 6 - Compound Ν 1.0 15 50 Comparative Example 2 7 - Compound U 1.0 21 55 ratio Comparative Example 2 8 A compound Υ 1.0 21 48 Comparative Example 2 9 - Compound I 1.0 18 43 Comparative Example 3 0 - Compound R 1.0 25 61 Comparative Example 3 1 - Compound Η 1,0 18 50 Comparative Example 3 2 - Compound Κ 1.0 15 45 Comparative Example 3 3 One-84 99 Accumulation of radiation: 7100 kLx · hr at 14 days, 13,540 kLx · hr for one month Test Example 2 Effect of preventing decomposition of suspending agent in etoxazole oil Test according to Formulation Example 2 Suspending agents in various oils are used as examples. Further, a suspension agent for removing only the ultraviolet light absorber from the preparation example 2, a suspension agent for removing only the oil of the various antioxidants, and a suspension agent for removing the ultraviolet light absorber and the various antioxidants are used as a comparative example. . The suspended oil in the prepared oil was applied to a glass culture jul having a diameter of 9 cm and placed under a sun irradiation for 2 weeks and 1 month. Then, 20 ml of n-hexane was placed in a glass 26 319273 200845902 " Petri dish to dissolve the sample. Take 2ml into Sep-pak (trade name) plus

Silicacartriges, rinsed with 5 ml of n-hexane to remove the effluent. Subsequently, it was washed with 5 ml of ethyl acetate, and the effluent was collected in an eggplant-shaped flask, and ethyl acetate was distilled off by a rotary distiller, and 2 ml of acetonitrile was accurately added to the residue to dissolve. The HPLC was used to quantify the woven fabric by an ultraviolet spectrophotometer. The same method as in Test Example 1 was used to obtain the "decomposition", and the results are shown in Table 3. Further, μ day; The results are shown in the following paragraphs and after 1 month, the exposure is the same, only in combination with the ΐ ί table. The results show that compared with the above Table 1 and Table 2, the light stability is known as /, phenolphthalein anti-deuteration agent The female sex of acetazole is enhanced by the multiplicative effect.

319273 27 200845902 •' Table 3 Disintegration rate of the suspension in oil of Formulation Example 2 (%) UV absorber added amount of antioxidant (parts) 1 month after 1 month Example 2 1 Compound (1) Compound L 0.25+0.25 8 16 Example 2 2 Compound (7) Compound Μ 0.25 + 0.25 7 12 Example 2 3 Compound (9) Compound Ρ 0.25 + 0.25 5 10 Example 2 4 Compound (1 1) Compound X 0.25 + 0.25 8 14 Example 2 5 Compound (2 0) Compound Ζ 0.25 + 0.25 8 18 Example 2 6 Compound (2 8 ) Compound I 0·25+0·25 3 8 Example 2 7 Compound (1 8) Compound S 0.25+0.25 6 11 Example 2 8 Compound (20) Compound W 0.25 + 0.25 9 17 Comparative Example 3 4 Compound (1) - 1.0 58 .78 Comparative Example 3 5 Compound (7) - 1.0 61 81 Comparative Example 3 6 Compound (9) 1.0 65 82 Comparative Example 3 7 Compound (1 1) - 1.0 66 87 Comparative Example 3 8 Compound (2 0) - L0 65 90 Comparative Example 3 9 Compound (2 S) - 1, 0 60 85 Comparative Example 4 0 Compound ( 1 8) — 1.0 55 75 Comparative Example 4 1 Compound (2 0) — 1.0 62 84 Comparative Example 4 2 A compound L 1.0 35 ^ 70 Comparative Example 4 3 A compound Μ 1.0 28 64 Comparative Example 4 4 A compound Ρ 1.0 20 48 Comparative Example 4 5 A compound X 1.0 22 55 Comparative Example 4 6 A compound Ζ 1.0 28 60 Comparative Example 4 7 A compound I 1.0 20 45 Comparative Example 4 8 A compound S 1.0 18 50 Comparative Example 4 9 - Compound W 1.0 21 61 Comparative Example 5 0 - - 87 100 Irradiation cumulative: 6220 kLx · hr on the 14th, 12,740 kLx · hr from 1 month

Test Example 3 Effect Test for Preventing Decomposition of Acetazole Emulsion Various emulsions were prepared in accordance with Formulation Example 3 as an example. Further, from the preparation of Example 3, only the emulsion of the ultraviolet light absorber was removed, only the emulsion of the phenolic antioxidant was removed, and the emulsion of the ultraviolet light absorber and the phenolic antioxidant was removed as a comparative example. The prepared emulsion was diluted with lg of water to a total amount of 100 ml. 4 ml of the diluted solution was placed in a glass petri dish having a diameter of 9 cm, and the water was evaporated to dryness, and then left to stand for 2 weeks and 1 month under sunlight. Glass culture 28 319273 200845902 , 20 ml of acetonitrile was placed in a dish and the sample was dissolved. The solution was collected in an eggplant-shaped flask, and the acetonitrile was distilled off by a rotary irrigator, and 2 ml of acetonitrile was accurately added to the residue and dissolved. Ethyl oxazole was quantified by HPLC with an ultraviolet spectrophotometer. Further, the decomposition rate by exposure to sunlight was determined in the same manner as in Test Example 1. The results are shown in Table 4. Further, the cumulative accumulation of radiation after 14 days and one month later is shown in the table of test results. As a result, in the same manner as in Tables 1, 2 and 3, when the ultraviolet light absorber and the phenolic antioxidant were used in combination, the light stability of the carbazole was enhanced to obtain a synergistic effect. • Table 4 Formulation Example 3 Emulsion Decomposition Rate (%) UV Absorber Antioxidant Addition C Part) 1 month after 1 month after Example 2 9 Compound (2 6 ) Compound C L0+1.0 4 7 Example 3 0 Compound (2) Compound I 1.0+1.0 3 6 Example 3 1 Compound (5) Compound 〇 1.0+1.0 5 9 Example 3 3 Compound (1 7 ) Compound Q 1.0+1.0 6 13 Example 3 4 Compound (1 6 Compound J 1.0+1.0 6 9 Comparative Example 5 1 Compound (2 6 ) - 5.0 50 75 Comparative Example 5 2 Compound (2 > - 5.0 48 70 Comparative Example 5 3 Compound (5) - 5.0 53 82 Comparative Example 5 4 Compound (17) - 5.0 65 86 Comparative Example 5 5 Compound (1 6 ) - 5.0 65 81 Comparative Example 5 6 - Compound C 5.0 17 40 Comparative Example 5 7 - Compound I 5.0 10 38 Comparative Example 5 8 A compound 〇 5.0 15 45 Comparative Example 5 9 - Compound Q 5.0 20 50 Comparative Example 6 0 A compound J 5.0 15 42 Comparative Example 6 1 One-to-one 87 99 Irradiation cumulative: 7530 kLx · hr at 14 days, 14 months, ISOkLx Hr

Test Example 4·Effect Test for Preventing Decomposition of Suspending Agent in Ethylhydrazine Water Various aqueous suspending agents were prepared in accordance with Formulation Example 4 as an example. In addition, it was prepared from the preparation of Example 4 to remove only the aqueous suspension of the ultraviolet light absorber, to remove only the phenolic antioxidant in the aqueous suspension, and to remove the ultraviolet light absorption 29 319273 200845902, the agent and the phenolic antioxidant in the water suspension agent as Comparative example. In the prepared water, the suspension was diluted with lg to 100 ml of the whole amount, and 4 ml of the diluted solution was placed in a glass petri dish having a diameter of 9 cm, and the water was evaporated, and then placed under sunlight for 2 weeks and 1 month. The sample was dissolved in 20 ml of acetonitrile in a glass petri dish, and the solution was collected in an eggplant-shaped flask. The acetonitrile was removed by distillation using a rotary emulsifier, and 2 ml of acetonitrile was accurately added to the residue to dissolve. Ethyl oxazole was quantified by HPLC with an ultraviolet photometric detector. The decomposition rate caused by exposure to sunlight was determined in the same manner as in Test Example 1. The results are shown in Table 5. Further, the cumulative accumulation of radiation after 14 days and one month later is shown in the table of test results. From the results, it can be seen that, similarly to Tables 1, 2, 3 and 4, when the ultraviolet light absorbing agent and the ruthenium antioxidant are used in combination, the light stability of the acetaminophen is enhanced. table 5

Formulation Example 4 Aqueous Suspension Decomposition Rate (%) UV Absorber Antioxidant Addition Amount (Parts) 1 month after 1 month after Example 3 5 Compound (3) Compound E 1.0+1.0 5 10 Example 3 6 Compound ( 2 1) Compound F 1.0+1.0 7 15 Example 3 7 Compound (2 2 ) Compound T 1.0+1.0 10 18 Example 3 8 Compound (2 4 ) Compound V 1.0+1.0 3 5 Example 3 9 Compound (1 3 Compound Z 1.0+1.0 8 9 Comparative Example 6 2 Compound (3) - 5.0 55 80 Comparative Example 6 3 Compound (2 1) - 5.0 61 83 Comparative Example 6 4 Compound (2 2) - 5.0 65 85 Comparative Example S 5 Compound (2 4 ) - 5.0 60 .87 Comparative Example 6 6 Compound (1 3 ) - 5.0 51 77 Comparative Example 6 7 - Compound E 5.0 17 48 Comparative Example 6 8 A compound F 5.0 13 37 Comparative Example 6 9 A compound 5.0 15 40 Comparative Example 7 0 - Compound V 5.0 11 42 Comparative Example 7 1 - Compound Z 5.0 19 55 Comparative Example 7 2 - One-to-one 80 97 Irradiation cumulative: 7530 kLx · hr at 14 days, 14,180 kLx at 1 month Hr 30 319273 200845902 In the second thorn. The blood of the true cockroach is going to test the path of known carbazole It has excellent killing and killing effects, but it has no insecticidal effect on adult worms. In this test, the initial effect and its line effect were evaluated by the killing effect. According to the preparation example, the oil agent prepared in accordance with the preparation example and the suspending agent in the oil prepared according to the preparation example 2 were perfused with 1 ml in a bovine body by 1 〇kg. Treatment] In the future, the female adult is released. Into the mistletoe and blood-sucking, collecting, the blood-sucking female cockroaches produced by the insects, preserved in 25 it, after 3 weeks to observe the hatching of the eggs, to obtain the hatching rate. In addition, the release rate of the female worms is also obtained after the feeding of the cockroach. From the results, it has been shown that the use of an ultraviolet light absorber or a phenolic antioxidant in combination with an ultraviolet light absorber or a phenol antioxidant alone contributes to the prolongation of the residual effect. Egg hatching rate (%) = (alcoholized eggs / number of eggs laid) ^ (10) Table β i by the agent and preparation example 2 ^ ^ suspending agent egg hatching rate 'UV light absorber antioxidant amount (parts) 1曰After 1 month, the application of the oil compound (2) Compound I 0.25 + 0.25 0 0 - Example 5 Oil compound (3) Compound K 0.25 + 0.25 0 0 ~ Example 10 Oil compound (8 Compound B 0.25 + 0.25 0 0 Comparative Example 2 Oil Compound (2) - 1.0 0 87 Comparative Example 14 Oil Agent - Compound I 1.0 0 52 Comparative Example 17 Oil Agent - ——. - 0 100 ' Example 21 Suspension Compound in Oil (1) Compound L 0.25+0.25 0 0 Example 22 Suspension Compound in Oil (7) Compound Μ 0.25 + 0.25 0 0 Example 26 Suspension Compound in Oil (28) Compound I 0.25+0.25 0 0 Comparative Example 34 Suspension Compound in Oil (1) - 1.0 0 81 Comparative Example 42 Suspension in Oil - Compound L 1.0 0 68 ^ Comparative Example 50 Suspension in Oil—————— 0 100 ' Test • Test Case _. .6 1^Number of the biological effects test of the chinchillas 31 319273 200845902 •-...the emulsion prepared according to the preparation example 3 and according to the preparation example Weekly water suspending agent 'in cat body|calling, in the cat's back neck using ι〇〇 times water dilution 4m b with acetonitrile azole 2mg, by microinjection needle perfusion. After 4 days of release, the printed product was recovered and transferred to a Petri dish. The collected eggs were stored at 25 ,, and after 3 weeks, they were observed and resolved. The situation was 'resolved.' After that, the female adult is also released, and the hatching rate is also obtained for the eggs. The results show that the ultraviolet light absorber and the phenol antioxidant are used together with the ultraviolet light absorber or the phenol antioxidant alone. The azole contributes to the prolongation of the residual effect. Table 7 i 1 agent of the season 5 agent and preparation of the water suspension of the suspension of the sample of Example 4 rri-T* » , wide \ ultraviolet light absorber antioxidant amount (parts) 1 month later 1 month Decoction Example 0 Emulsion Compound (2) Compound I 1.0+1.0 0 /4 1 Again 0 Example 31 Oxide Emulsion Compound (5) Compound 0 1.0+1.0 0 0 Example 34 _Emulsion Compound (16) Compound J 1.0+1.0 0 〇tb Comparative Example 55 _ Emulsion Compound (16) One 5.0 0 82 than the car father Example 60 Emulsion Compound J 5.0 0 70 Comparative Example 61 __ Emulsion - 0 99 Example 36 Suspension g Compound C21) Compound rl 1.0+1.0 0 〇 Example 37 Suspending Agent Compound (22) 1 Compound Τ 1·0+ 1·0 0 〇 Example 39 Μ Suspending Agent Compound (13) Compound Ζ 1.0+1.0 0 〇Comparative Example 64 Suspending Agent Compound (22) — 5.0 0 80 Comparative Example 69 ΜSuspending Agent-Compound Τ 5.0 0 65 Comparative Example 72 it suspending agent — — 0 100 319273 32

Claims (1)

200845902 * X. Patent application scope: The composition of the external parasite repellent of the animal, which is composed of > 〇 , 1 and B terminal, and contains ultraviolet light absorber and phenolic antioxidant. 2. If you apply for a patent scope! The external parasitic cockroach repellent composition, wherein the ultraviolet absorbing agent is selected from the following group of compounds! Two or more kinds of compounds: " The benzophenone compound represented by the general formula (I) (wherein R1 represents a hydrogen atom, a burnt group having a straight or branched chain having a carbon number of from 12 to 12, a benzyl group or a group represented by the formula (1), R2 represents a halogen atom, a sulfonic acid group, or a group represented by the formula (2), (2) R3 represents a hydrogen atom or a thiol group, R4 represents a hydrogen atom, a hydroxy group or a methoxy group), and a cyanopropionate compound represented by the general formula (II), 33 319273, '(II)200845902 CN^COOR5 (in the formula: R is not a reverse number of 1 to 8 with a direct bond or a branching key. The general formula (III) shows a stupid triazole compound, HO R6 R9 (III) (wherein R6 represents a hydrogen atom, an alkyl group having a linear or branched chain having a carbon number of i to 5, an α,α,-dimercaptobenzyl group, and a group represented by the formula (3) , 〇\\ C, (3) 〇 or the base of formula (4), OH R Straight gold $ 士八u ' annihilator number 1 to 8, 罝 chain or branched chain alkyl, methoxy, , α _ dimethyl benzophenone 319273 34 200845902 — or methacryloxy group 9 a tfm, a helium atom or a chlorine atom), and a compound (V) which is not a salicylic acid compound, Γ0^Ο^1 (IV) (wherein, the alkyl group of the Rio branch). A non-hydrogen atom or a linear one with a carbon number of 1 to 8 or a composition of the external parasite repellent as described in the patent application scope s s φ _ , the cat-based anti-emulsifier is used in the following compound group One or two or more compounds are selected: a monophenolic compound represented by the general formula (V); R13 OH (V) ^ (wherein RU represents a hydrogen atom, an isopropyl group, a chlorohydrazine group, a tert-butyl group, a benzyl group, a methylphenyl fluorenyl group, or a methacrylate group, and R12 represents a hydrogen atom or a Dibutyl, Rl3 represents a hydrogen atom, a mercapto group, an ethyl group, a methoxy group, an isooctyl group, an acid vine or a stearyl vine group, R14 represents a hydrogen atom or a fluorenyl group, and R 5 is not a hydrogen atom or carbon. The number is a linear or branched alkyl group of 丨 to $), and the following double compound or multi-aged compound represented by (1) to (13). (1) 2, 2, methylene double (4-mercapto-6-t-butylphenol), 35 319273 200845902 ^ (2) 2,2'·methylenebis(4-ethyl-6-tertiary butyl), ... one (3) 4,4,-thiobis(3-methyl-6.t-butylphenol), (4) 4,4'-butylenebis(3-methyl-6-tert-butylphenol), (5) 3,9-bis[1,1-didecyl-2_[β-(3-tert-butyl-4-ylhydroxy-5-phenylphenyl)propenyloxy]ethyl]-2,4 ,8,10-tetraoxaspiro[5,5]undecane, (6) 2,2-thiodivinylbis[3-(3,5-di-t-butyl-4-hydroxyphenyl) Propionate], (7) Diethylenol bis [3_(3·2,2-butyl-4-yl-5-tolyl) Propionate, (8) 1,6-hexanediol bis[3·(3,5_di-t-butyl-4-hydroxyphenyl)propionate]' (9) 1,1,3 -Tris(2_fluorenyl-4-hydroxy-5_t-butylphenyl)butane, (1〇) 1,3,5-trimethyl-254,6-tris (3,5-di Tributyl-4-hydroxybenzyl)benzene, (11) tetrakis[-indenyl-3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate]decane, ( 12) Tris(3,5-di-t-butyl-4-hydroxyphenylhydrazyl)isocyanuric acid S, or (13) bis[3,3'-bis-(4'-hydroxy·3,- Tributylphenyl)butyric acid]ethylene glycol. The composition of the external parasite repellent according to any one of the first to third aspects of the invention, wherein the ratio of the oxazole, the ultraviolet light absorber and the phenolic antioxidant is in a mass ratio, i : 〇·〇5 to 5 : 〇·〇5 to 5 range. 319273 36 200845902 # 5 · A method for repelling external parasites, characterized by the use of an external parasite repellent as set forth in any one of claims 1 to 4. 37 319273 200845902 , VII. Designated representative map: There is no schema in this case. (1) The representative representative figure of this case is: (). (2) A brief description of the symbol of the representative figure: 8. If there is a chemical formula in this case, please disclose the chemical formula that best shows the characteristics of the invention: (I) 4 319273