TW200831130A - Pharmaceutical compositions comprising a bisphosphonate compound - Google Patents
Pharmaceutical compositions comprising a bisphosphonate compound Download PDFInfo
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- TW200831130A TW200831130A TW096143764A TW96143764A TW200831130A TW 200831130 A TW200831130 A TW 200831130A TW 096143764 A TW096143764 A TW 096143764A TW 96143764 A TW96143764 A TW 96143764A TW 200831130 A TW200831130 A TW 200831130A
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- 229940122361 Bisphosphonate Drugs 0.000 title claims abstract description 42
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 31
- -1 bisphosphonate compound Chemical class 0.000 title abstract description 26
- 238000011200 topical administration Methods 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims description 176
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 99
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 76
- 210000000988 bone and bone Anatomy 0.000 claims description 48
- 230000002500 effect on skin Effects 0.000 claims description 40
- 150000004663 bisphosphonates Chemical class 0.000 claims description 39
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 39
- 235000011187 glycerol Nutrition 0.000 claims description 38
- 238000000034 method Methods 0.000 claims description 30
- 239000002253 acid Substances 0.000 claims description 29
- 210000002700 urine Anatomy 0.000 claims description 29
- 239000004094 surface-active agent Substances 0.000 claims description 28
- 239000003349 gelling agent Substances 0.000 claims description 27
- 239000003795 chemical substances by application Substances 0.000 claims description 25
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 23
- 238000011282 treatment Methods 0.000 claims description 22
- 238000011084 recovery Methods 0.000 claims description 21
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 19
- 238000001990 intravenous administration Methods 0.000 claims description 18
- 230000003020 moisturizing effect Effects 0.000 claims description 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 17
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 16
- 239000003814 drug Substances 0.000 claims description 16
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims description 16
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- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims description 14
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- 244000118350 Andrographis paniculata Species 0.000 claims description 7
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims description 6
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- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 1
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- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- IIDJRNMFWXDHID-UHFFFAOYSA-N Risedronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CC1=CC=CN=C1 IIDJRNMFWXDHID-UHFFFAOYSA-N 0.000 claims 1
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- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
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- 229940062527 alendronate Drugs 0.000 description 46
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- 210000004207 dermis Anatomy 0.000 description 44
- 229910019142 PO4 Inorganic materials 0.000 description 41
- 239000010452 phosphate Substances 0.000 description 41
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 38
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- XAHQYEAIJGTPET-JEDNCBNOSA-N [(1s)-5-amino-1-carboxypentyl]azanium;dihydrogen phosphate Chemical compound OP(O)([O-])=O.NCCCC[C@H]([NH3+])C(O)=O XAHQYEAIJGTPET-JEDNCBNOSA-N 0.000 description 12
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- 239000005642 Oleic acid Substances 0.000 description 11
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 11
- 150000002148 esters Chemical class 0.000 description 11
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 11
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- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 11
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- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 9
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- PAYGMRRPBHYIMA-UHFFFAOYSA-N sodium;trihydrate Chemical class O.O.O.[Na] PAYGMRRPBHYIMA-UHFFFAOYSA-N 0.000 description 5
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- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 1
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- 239000002953 phosphate buffered saline Substances 0.000 description 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-O phosphonium Chemical compound [PH4+] XYFCBTPGUUZFHI-UHFFFAOYSA-O 0.000 description 1
- 150000003017 phosphorus Chemical class 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- MQHNKCZKNAJROC-UHFFFAOYSA-N phthalic acid dipropyl ester Natural products CCCOC(=O)C1=CC=CC=C1C(=O)OCCC MQHNKCZKNAJROC-UHFFFAOYSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229940081066 picolinic acid Drugs 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
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- 239000001259 polydextrose Substances 0.000 description 1
- 235000013856 polydextrose Nutrition 0.000 description 1
- 229940035035 polydextrose Drugs 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
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- 150000003077 polyols Chemical class 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- NGXSWUFDCSEIOO-UHFFFAOYSA-N pyrrolidin-3-amine Chemical compound NC1CCNC1 NGXSWUFDCSEIOO-UHFFFAOYSA-N 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
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- 230000000717 retained effect Effects 0.000 description 1
- 235000019685 rice crackers Nutrition 0.000 description 1
- AOXSEDODBLDTLD-UHFFFAOYSA-K ruthenium(3+);phosphate Chemical compound [Ru+3].[O-]P([O-])([O-])=O AOXSEDODBLDTLD-UHFFFAOYSA-K 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
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- 239000011780 sodium chloride Substances 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- BXENOJAVIDVHOV-UHFFFAOYSA-M sodium;dihydrogen phosphate;trihydrate Chemical class O.O.O.[Na+].OP(O)([O-])=O BXENOJAVIDVHOV-UHFFFAOYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
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- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- PWEBUXCTKOWPCW-UHFFFAOYSA-N squaric acid Chemical class OC1=C(O)C(=O)C1=O PWEBUXCTKOWPCW-UHFFFAOYSA-N 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000010902 straw Substances 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- 159000000008 strontium salts Chemical class 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
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- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229940037128 systemic glucocorticoids Drugs 0.000 description 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 229910052715 tantalum Inorganic materials 0.000 description 1
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 238000003856 thermoforming Methods 0.000 description 1
- 229940019375 tiludronate Drugs 0.000 description 1
- RRHXZLALVWBDKH-UHFFFAOYSA-M trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium;chloride Chemical compound [Cl-].CC(=C)C(=O)OCC[N+](C)(C)C RRHXZLALVWBDKH-UHFFFAOYSA-M 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 230000036325 urinary excretion Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86629406P | 2006-11-17 | 2006-11-17 | |
| US86630606P | 2006-11-17 | 2006-11-17 | |
| EP06291785A EP1923049A1 (en) | 2006-11-17 | 2006-11-17 | Pharmaceutical compositions comprising a bisphosphonate compound |
| EP06291786A EP1923050A1 (en) | 2006-11-17 | 2006-11-17 | Liquid pharmaceutical compositions comprising a bisphosphonate compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200831130A true TW200831130A (en) | 2008-08-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| TW096143764A TW200831130A (en) | 2006-11-17 | 2007-11-19 | Pharmaceutical compositions comprising a bisphosphonate compound |
| TW096143765A TW200829282A (en) | 2006-11-17 | 2007-11-19 | Liquid pharmaceutical compositions comprising a bisphosphonate compound |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW096143765A TW200829282A (en) | 2006-11-17 | 2007-11-19 | Liquid pharmaceutical compositions comprising a bisphosphonate compound |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20080167271A1 (enExample) |
| EP (2) | EP2088996A1 (enExample) |
| JP (2) | JP2010510194A (enExample) |
| AR (2) | AR064263A1 (enExample) |
| AU (2) | AU2007321108A1 (enExample) |
| CA (2) | CA2669489A1 (enExample) |
| IL (2) | IL198678A0 (enExample) |
| TW (2) | TW200831130A (enExample) |
| WO (2) | WO2008059060A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2007321108A1 (en) * | 2006-11-17 | 2008-05-22 | Besins Healthcare | Pharmaceutical compositions comprising a bisphosphonate compound |
| EP2147674A1 (en) * | 2008-07-24 | 2010-01-27 | Besins Healthcare | Transdermal pharmaceutical compositions comprising danazol |
| US9169279B2 (en) | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| AU2010278860B2 (en) * | 2009-07-31 | 2016-05-26 | Thar Pharma, Llc | Crystallization method and bioavailability |
| US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| US9340565B2 (en) | 2010-11-24 | 2016-05-17 | Thar Pharmaceuticals, Inc. | Crystalline forms |
| WO2017208070A1 (en) | 2016-05-31 | 2017-12-07 | Grünenthal GmbH | Bisphosphonic acid and coformers with lysin, glycin, nicotinamide for treating psoriatic arthritis |
| US12377149B2 (en) | 2018-06-01 | 2025-08-05 | The University Of North Carolina At Chapel Hill | Injectable thermoresponsive hydrogels as a combinatory modality for controlled drug delivery, biomaterial implant and 3D printing bioink |
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| MX21452A (es) * | 1989-07-07 | 1994-01-31 | Ciba Geigy Ag | Preparaciones farmaceuticas que se administran en forma topica. |
| MX21453A (es) * | 1989-07-07 | 1994-01-31 | Ciba Geigy Ag | Preparaciones farmaceuticas que se administran en forma topica. |
| GB9408775D0 (en) * | 1994-05-04 | 1994-06-22 | Ciba Geigy Ag | Use of certain methanebisphosphonic acid derivatives to prevent prothesis loosening and prothesis migration |
| JP3411690B2 (ja) * | 1994-09-21 | 2003-06-03 | 帝人株式会社 | 局所投与用アレンドロン酸ナトリウム製剤 |
| US6905701B2 (en) * | 1997-06-11 | 2005-06-14 | Umd, Inc. | Formulations for transmucosal vaginal delivery of bisphosphonates |
| WO2000028982A2 (en) * | 1998-11-19 | 2000-05-25 | The Board Of Trustees For The University Of Arkansas | Increasing bone strength with selected bisphosphonates |
| US20050074487A1 (en) * | 1999-12-16 | 2005-04-07 | Tsung-Min Hsu | Transdermal and topical administration of drugs using basic permeation enhancers |
| JP2001253827A (ja) * | 2000-02-15 | 2001-09-18 | Pfizer Prod Inc | 骨粗鬆症を治療するための組成物および方法 |
| CN1180846C (zh) * | 2000-05-05 | 2004-12-22 | 霍夫曼-拉罗奇有限公司 | 含有双膦酸或其盐的,用于皮下给药的凝胶体状药物组合物 |
| CN1633300A (zh) * | 2002-02-14 | 2005-06-29 | 山之内制药株式会社 | 透皮制剂 |
| JP4394888B2 (ja) * | 2002-02-14 | 2010-01-06 | 救急薬品工業株式会社 | 経皮投与製剤 |
| AU2004257674A1 (en) * | 2003-07-11 | 2005-01-27 | Macrochem Corporation | Pharmaceutical compositions for topical application |
| MY141763A (en) * | 2003-09-18 | 2010-06-30 | Novartis Ag | Pharmaceutical products comprising bisphosphonates |
| US20050119230A1 (en) * | 2003-09-18 | 2005-06-02 | Alexandra Glausch | Pharmaceutical products comprising bisphosphonated |
| WO2005037157A1 (en) * | 2003-10-14 | 2005-04-28 | Dermatrends, Inc. | Enhancing transdermal administration of hydrophilic drugs |
| AU2007321108A1 (en) * | 2006-11-17 | 2008-05-22 | Besins Healthcare | Pharmaceutical compositions comprising a bisphosphonate compound |
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2007
- 2007-11-16 AU AU2007321108A patent/AU2007321108A1/en not_active Abandoned
- 2007-11-16 US US11/941,417 patent/US20080167271A1/en not_active Abandoned
- 2007-11-16 JP JP2009536745A patent/JP2010510194A/ja active Pending
- 2007-11-16 CA CA002669489A patent/CA2669489A1/en not_active Abandoned
- 2007-11-16 CA CA002669488A patent/CA2669488A1/en not_active Abandoned
- 2007-11-16 WO PCT/EP2007/062473 patent/WO2008059060A1/en not_active Ceased
- 2007-11-16 WO PCT/EP2007/062472 patent/WO2008059059A1/en not_active Ceased
- 2007-11-16 JP JP2009536746A patent/JP2010510195A/ja active Pending
- 2007-11-16 EP EP07847196A patent/EP2088996A1/en not_active Withdrawn
- 2007-11-16 AU AU2007321109A patent/AU2007321109A1/en not_active Abandoned
- 2007-11-16 AR ARP070105121A patent/AR064263A1/es unknown
- 2007-11-16 US US11/941,393 patent/US20080182822A1/en not_active Abandoned
- 2007-11-16 AR ARP070105120A patent/AR064262A1/es unknown
- 2007-11-16 EP EP07847195A patent/EP2114368A1/en not_active Withdrawn
- 2007-11-19 TW TW096143764A patent/TW200831130A/zh unknown
- 2007-11-19 TW TW096143765A patent/TW200829282A/zh unknown
-
2009
- 2009-05-11 IL IL198678A patent/IL198678A0/en unknown
- 2009-05-12 IL IL198698A patent/IL198698A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20080167271A1 (en) | 2008-07-10 |
| IL198678A0 (en) | 2010-02-17 |
| US20080182822A1 (en) | 2008-07-31 |
| CA2669489A1 (en) | 2008-05-22 |
| AR064262A1 (es) | 2009-03-25 |
| WO2008059059A1 (en) | 2008-05-22 |
| AR064263A1 (es) | 2009-03-25 |
| CA2669488A1 (en) | 2008-05-22 |
| AU2007321108A1 (en) | 2008-05-22 |
| JP2010510194A (ja) | 2010-04-02 |
| EP2114368A1 (en) | 2009-11-11 |
| AU2007321109A2 (en) | 2009-06-11 |
| JP2010510195A (ja) | 2010-04-02 |
| TW200829282A (en) | 2008-07-16 |
| WO2008059060A1 (en) | 2008-05-22 |
| AU2007321109A1 (en) | 2008-05-22 |
| EP2088996A1 (en) | 2009-08-19 |
| IL198698A0 (en) | 2010-02-17 |
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