TW200824739A - Ophthalmic injection method - Google Patents

Abstract

A method of delivering a substance into an eye includes recognizing a connection between a tip segment and a limited reuse assembly; receiving dosage information from the tip segment; activating a temperature control device to alter a temperature of a substance to be delivered into an eye; receiving temperature information from a thermal sensor; using the temperature information to control the temperature control device; receiving an input indicating that the substance is to be delivered; and based on the dosage information, controlling an actuator to move a plunger to deliver the substance.

Description

200824739 IX. Description of the invention: [Purchase of the genus of the genus of the genus of the genus of the genus of the genus of the genus of the genus of the genus of the genus of the genus of the genus of the genus of the genus of the genus of the genus U.S. Patent Application Serial No. 60/921,498, filed on Oct. 16, 2006, and U.S. Patent Application Serial No. 60/921,499, issued on Part of the continuation of U.S. Patent Application Serial No. 11/435,906, which was filed on May 17th. BACKGROUND OF THE INVENTION The present invention relates to a single use medical device and more particularly to a two-part ophthalmic drug delivery device having a disposable tip comprising an improved plunger link and seal. Several diseases and conditions in the posterior segment of the eye can threaten vision. Age-related 15 spot degeneration (ARMD), choroidal neovascularization (CNV), retinopathy (eg, diabetic retinopathy, vitreoretinopathy), retinitis (such as giant cell disease (CMV) retinitis), grapes Membrane inflammation, macular edema, glaucoma, and neuropathy are several examples. Drugs can be injected into the eye to treat these and other diseases. These 20 injections are usually performed manually using a conventional syringe and needle. Figure 1 is a perspective view of a prior art syringe for injecting a drug into the eye. In the drawing, the syringe includes a needle 105, a luer hub n, a chamber 115, a column plug 0, a plunger shaft 125, and a thumb rest 13 〇. As is generally known, the injectable drug is located in chamber 115. The thumb is caused by the pushing system on the seat of the seat. 5 200824739 - 5 V w 120 The drug is driven out through the needle 105. When using this syringe, the surgeon needs to puncture the ocular tissue with a needle, securely hold the syringe, and actuate the syringe plunger (with or without the help of a nurse) to inject fluid into the eye. Because the vernier scale on the syringe is not precise for small injection volumes, the injected volume is usually not controlled in an accurate manner. The fluid flow rate is not controlled. The vernier scale reading is also subject to parallax error. Tissue damage may occur due to "unstable" injections. Drug reflux can also occur when the needle is removed from the eye. Efforts have been made to control the delivery of small amounts of liquid. One commercially available liquid dispenser 10 is the ULTRATM Actuated Displacement Dispenser from FED Inc. of Provence, Rhode Island. ULTRA dispensers are commonly used to dispense small quantities of industrial adhesives. It utilizes a conventional syringe and a custom dispensing tip. The tip of the injector is actuated using an electric stepper motor and a constant fluid. Parker Hannifin Corporation, Cleveland, Ohio 15 • The W Department distributes a small liquid dispenser for drug discovery applications manufactured by Aurora Instruments LLC of San Diego, California. The Parco/Eurora dispenser utilizes a piezoelectric-electrical dispensing mechanism. Swiss company Ypsomed (Inc.) produces injection pens and automated syringes for use in one of the patient's insulin or hormone self-injection lines. This 20 product line includes simple disposable pens and electrically controlled motorized syringes. U.S. Patent No. 6,290,690 discloses the application of a viscous fluid (such as a sulphuric acid) to the eye during a fluid/fluid exchange during surgery to simultaneously aspirate a second viscous fluid (such as a fluorinated carbon liquid) from the eye to repair the retina. An eye system that is detached or torn. The system includes a conventional injection 6 200824739 device containing a plunger. The syringe-end fluid type is combined to a pneumatic pressure source for providing a pneumatic pressure to actuate the plunger. The other end of the syringe is fluidly coupled via a tube to a perfusion cannula to deliver the viscous fluid to be injected. ‘#有有—Portable handpieces for injecting _drug into the eye, v 5纟 include—can be attached to and removed from the relatively easy-to-reuse assembly. The efficiency and cost-effectiveness of the drug delivery system is improved by placing the more expensive components, such as electronic components and "drive mechanisms," in the reusable assembly while maintaining the sterile components in the tip. = With - 10% of the reusable components and functions used for the injection procedure. It is also desirable to have a disposable disposable tip section that can be easily attached to I repeatedly using total red for injection and then easily removed and disposed of after injection. This system offers many benefits over prior art injectors. C. OBJECTIVE 3 SUMMARY OF THE INVENTION 15 The present invention is consistent with one embodiment. The present invention is a method for delivering a substance to an eye. The method includes identifying - the tip segment and the - connection between the finite overlap assembly; the self-tip segment receiving the dose information 'start-temperature control device to change the wheel to be sent to - in the eye - Substance-temperature; self-thermal sensor receiving temperature information. Use this temperature information to control the temperature control device; receiving - used to indicate that the substance j will be transported; and based on the dose information, control - The squirrel moves the plunger to transport the substance. In another embodiment, which is presented in accordance with the principles of the present invention, the present invention is a method for delivering a substance to an eye. The method includes identifying 20 200824739 a connection between a tip end section and a finite overlap use assembly; identifying a type of tip end section connected to the finite overlap use assembly; receiving from the tip end section Dose information; initiating a temperature control device to change a temperature to be delivered to a substance in one eye; receiving temperature information from a thermal sensor; causing 5 to use the temperature information to control the temperature control device; Moving to a home position; moving the actuator to bring a mechanical link interface into contact with a plunger interface prior to injection into the eye; receiving an input indicating that the substance is to be delivered; the substance has arrived appropriate After the temperature, the dose is used to control the actuator to move the plunger to deliver the substance to an eye; 10 receiving a paste from the displacement sensor for indicating that the actuator shaft has moved a distance, and This distance provides an indication of one of the delivered doses. The above general description and the following detailed description are merely exemplary and illustrative and are intended to provide a further description of the claimed invention. The additional features and objects of the present invention are set forth and suggested by the following description and the present disclosure. BRIEF DESCRIPTION OF THE DRAWINGS The accompanying drawings, which are incorporated in FIG. 1 is a perspective view of a prior art syringe; FIG. 2 is a diagram of an ophthalmic medical device including a disposable tip 20 end region and a limited repetitive use assembly according to an embodiment of the present invention; BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 is a further embodiment of a finite overlap assembly according to one of the principles of the present invention; - Figure 1 is a cross-sectional view of another embodiment of a finite overlap assembly in accordance with the principles of the present invention; 8 200824739 5 is a cross-sectional view of a disposable tip section and a finite overlap assembly in accordance with an embodiment of the present invention; FIG. 6 is a view of a consistent medical device for use in an ophthalmic medical device in accordance with the present invention; Cross-sectional view of the disposable tip section; 5 Figure 7 is a cross-sectional view of a disposable tip section for an ophthalmic medical device in accordance with one embodiment of the present invention; An embodiment of the invention - a cross-sectional view of the disposable tip section and a partial view of a finite overlap assembly; Figure 9A is an illustration of an embodiment of the invention for an ophthalmic treatment 10 Cross-sectional view of the disposable tip section of the device ; An end view of an embodiment of a first graph of FIG. 9A 9B; a second graph 10A-10D may be in the diagram according to embodiments of the present invention comprises four different circuits. Figure 11 is a view of an end 15 of a finite overlap assembly in accordance with the principles of the present invention, and Figure 12 is a cross-sectional view of a finite overlap assembly in accordance with an embodiment of the present invention; A cross-sectional view of a finite overlap assembly using one of the embodiments of the invention; 20 Figures 14 and 15 are cross-sectional views of two assemblies in accordance with the principles of the present invention; and Figure 16 is a finite overlap in accordance with the principles of the present invention. A cross-sectional view of the assembly, the tip section, and a charging substrate; FIGS. 17A and 17B are flow diagrams of a method for injecting a substance 9 200824739 into an eye in accordance with one of the principles of the present invention; A flow chart of a method of injecting a substance into an eye in accordance with one of the principles of the present invention; FIG. 19 is a flow chart showing a method of injecting a substance into a 5 eye in accordance with one of the principles of the present invention; One of the principles of the present invention relates to a flow chart of a method of injecting a substance into an eye. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Now, an exemplary embodiment of the present invention is shown in the drawings. Where possible, the same reference numbers will be used in the drawings to represent the same or similar parts. 2 is a diagram of an ophthalmic medical device including a retractable tip section and a limited repetitive use assembly in accordance with an embodiment of the present invention. In Fig. 2, the medical device includes a tip end section 205 and a finite overlap use assembly 250. The tip section 205 includes a needle 210, a housing 215, and an optional light 275. The finite overlap assembly 250 includes a housing 255, a switch 270, a lock mechanism 265, and a threaded portion 260. The tip section 205 can be connected to and removed from the finite overlap using a total of 250. In this embodiment, the tip section 205 has a threaded portion on an interior surface of the housing 215 that is threaded onto the threaded portion 260 of the finite overlap assembly 250. In addition, the lock mechanism 265 secures the tip end section 215 to the limited repeat use assembly 250. The lock mechanism 265 can be in the form of a button, a slide switch, or a cantilevered mechanism. Other mechanisms for attaching the tip section 205 to the 200824739 to the P-repetitive use assembly 250, such as those comprising mating features that are butted to each other, are generally known in the art and are within the scope of the present invention. . The needle 210 is adapted to deliver a substance such as a drug to one eye. Needle 5 210 can be any common known configuration. The taro 210 is preferably designed such that its thermal characteristics contribute to a particular drug delivery application. For example, when a heated drug is to be delivered, the needle 210 may be of relatively short (several mm) length (for thermal use) to facilitate proper delivery of the drug. Switch 270 is adapted to provide an input to the system. For example, switch 10 270 can be used to activate the system or to turn on a temperature control device. Other switches, buttons, or user-guided control inputs are typically known and may be used in conjunction with the limited use assembly 250 and/or tip section 205. The optional light 275 illuminates when the tip section 205 is ready for use. The optional light 275 can be raised from the housing 215 or it can be enclosed within the 15 housing 215, in which case the optional light 275 can be seen through a colorless portion of the housing 215. In other embodiments, the optional light 275 can be replaced by an indicator such as a liquid crystal display, a segmented display, or other means for indicating the status or condition of the disposable tip section 205. For example, the optional light 275 can illuminate the pulse to indicate other conditions such as, but not limited to, a 20 system error, a fully charged battery, an undercharged battery or tip section 205, and a finite overlap between the assembly 250 errors. connection. While the display is on the tip section 205, an optional light 275 or an additional indicator can be placed on the limited repeat use assembly 250. Figure 3 is a further embodiment of a finitely repetitive use assembly according to the principles of the present invention. The limited repeat use assembly 250 includes a button 308, a display 320, and a housing 330. The disposable tip section 205 is attached to the end 340 of the finite reuse assembly 250. Button 308 is actuated to provide an input to the system. Like switch 270, button 308 can activate a temperature control device or initiate actuation of a plunger. Display 320 is a liquid crystal display, a segment display, or other means for indicating the status or condition of disposable disposable tip section 205 or limited repeat use assembly 250. 4 is a cross-sectional view of another embodiment of a finite overlap assembly in accordance with the principles of the present invention. In Fig. 4, power source 505, interface 517, actuator 515, and actuator shaft 510 are disposed in housing 255. The top portion of the housing 255 has a threaded portion 260. The lock mechanism 265, the switch 270, the button 308, and the indicators 306, 307 are all disposed on the housing 255. The power source 505 is typically a rechargeable battery such as a lithium ion battery, but other types of batteries may be employed. In addition, any other type of power cell is suitable for power source 505. Power source 505 provides power to the system, and more particularly to actuator 515. Power source 505 also provides power to a tip section that is coupled to a limited reuse assembly 250. In this example, power source 505 can provide power to a temperature control device (not shown) disposed in the tip end. Alternatively, power source 505 can be removed from housing 255 via a door or other similar feature 20 structure (not shown). Interface 517 is typically an electrical conductor that allows power to flow from power source 5〇5 to actuator 515. Other interfaces, such as interface 517, may also be present to provide power to other portions of the system. The actuator shaft 510 is coupled to and driven by the actuator 515. Actuator 515 12 200824739 ' 5 W is typically a stepper motor or other type of motor capable of moving the actuator shaft 51 确切 the exact distance. In one embodiment, the actuator shaft 510 is coupled to a tip end section via a mechanical linkage to deliver a medicament to an eye. In this example, actuator 515 is a stepper motor that can accurately move shaft 51 to deliver an exact amount of drug to the eye. Actuator 515 is secured to an interior surface of housing 255, for example, by a tab for engaging the outer surface of actuator 515. In other embodiments, the actuator 515 is a linear actuator or a linear actuator. In this example, the actuator 515 can be a spring or spring-driven mechanism, a geared DC 10 motor having a rotary sensor coupled to a linear actuator, or a coupled to a linear sensor. A linear actuator DC motor, or a linear stepper motor. Other types of motors, such as rotating permanent magnet motors, may also be used with actuator 515. Lock mechanism 265, switch 270, and button 308 are all disposed on housing 255 such that they can be manipulated by hand. Similarly, the indicators 306, 307 are disposed on the housing 255 15 to make them viewable. Lock mechanism 265, switch 270, button 308, and indicators 306, 307 are also coupled to a controller (not shown) via an interface (not shown) disposed in housing 255. Figure 5 is a cross-sectional view of a disposable tip segment and a finite overlap assembly in accordance with an embodiment of the present invention. Figure 5 shows how the tip section 20 205 forms an interface with the finite overlap assembly 250. In the embodiment of Figure 5, the tip section 205 includes an assembly 555, a plunger interface 420, a plunger 415, a dispensing chamber housing 425, a tip section housing 215, a temperature control device 450, a thermal sensor. 460, needle 210, delivery chamber 405, interface 530, and tip interface connector 453. The finite overlap assembly 250 includes a mechanical linkage interface 545, 13 200824739 actuator shaft 510, actuator 515, power source 505, controller 305, limited repetitive use assembly housing 255, interface 535, and limited The assembly interface connector 553 is reused. In the tip section 205, the plunger interface 420 is disposed on one end 5 of the plunger 415. The other end of the plunger 415 forms one end of the delivery chamber 405. The plunger 415 is adapted to slide within the dispensing chamber 405. The outer surface of the plunger 415 is fluidly sealed to the inner surface of the dispensing chamber housing 425. The dispensing chamber housing 425 surrounds the dispensing chamber 405. In general, the dispensing chamber housing 425 has a cylindrical shape. Therefore, the delivery chamber 405 also has a cylindrical shape. In the tip section 205, the assembly 555 includes any number of components, as described below. The needle 210 is fluidly coupled to the dispensing chamber 405. In this case, a substance enclosed in the dispensing chamber 405 can pass through the needle 21 and into one eye. The temperature control device 450 at least partially surrounds the dispensing chamber housing 425. In this example, the temperature control device 450 is adapted to heat and/or cool any of the contents of the dispensing chamber housings 425 and 15 that are enclosed in the dispensing chamber 405. Interface 530 connects temperature control device 450 to tip interface connector 453. The components of the tip section 205, including the dispensing chamber housing 425, the temperature control device 450, and the plunger 415 are at least partially surrounded by the tip section housing 215. In one embodiment consistent with the principles of the present invention, the plunger 415 is sealed 2 to the interior surface of the dispensing chamber housing 425. This seal prevents contamination of any material trapped in the dispensing chamber 405. For medical use, this seal is desirable. This seal can be placed at any point on the plunger 415 or the delivery chamber housing 425. The finite overlap uses the assembly 25 ,, and the power source 5 〇 5 provides power to the actuation 515. The interface between power source 505 and actuator 515 (not shown in Figure 14 200824739) serves as a conduit for providing electrical power to actuator 515. Actuator 515 is coupled to actuator shaft 510. When the actuator 515 is a stepping motor, the actuator shaft 510 is integral with the actuator 515. Mechanical linkage interface 545 is coupled to actuating shaft 510. In this configuration, as the actuator 515 moves the actuator shaft 51 up to the needle 210, the mechanical linkage interface 545 also moves up the needle 210. In other embodiments of the invention, the mechanical linkage interface 545 and the actuator shaft 51 are a single component. In other words, a shaft coupled to the actuator 515 includes an actuator shaft 510 and a mechanical linkage interface 545 that are a single assembly. Controller 305 is coupled via interface 535 to a finite overlap use assembly interface 10 connector 553. The finite overlap assembly 553 is disposed on a top surface of the finite overlap assembly assembly housing 255 adjacent the mechanical linkage interface 545. In this manner, both the finite overlap assembly interface connector M3 and the mechanical linkage interface 545 are suitably coupled to the tip interface connector 453 and the plunger interface 420 〇 15 controller 305 and actuator 515, respectively. Connected by an interface (not shown). This interface (not shown) may allow the controller 3〇5 to control the operation of the actuator 515. In addition, an interface (not shown) between power source 505 and controller 305 can allow controller 305 to control the operation of power source 505. In this example, the controller can control the charging and discharging of the power source milk when the power source 505 is a rechargeable battery. The controller 305 is typically an integrated circuit capable of performing power, input, and wheel locks in one of the logic functions. In various embodiments, controller 3〇5 is a target device controller. In this example, the controller 3〇5 performs a function such as a temperature control device or a power supply, a specific device or component. For example, a temperature control device controller has basic functions for controlling/drain control devices. In other embodiments, the controller milk is a Μ processor. In this case, the controller 3〇5 can be programmed to operate • not only the components of the health control. In other cases, the controller is not: 5 (four) microprocessor, but as a specific configuration control that can be controlled to perform different - different components of the work I. Although depicted in Figure 5 as a component, controller 305 can be fabricated from a number of different components or integrated circuits. • The tip section 205 is adapted to be docked or attached to a limited repetitive use assembly 250. In the embodiment of FIG. 5, the post 10 is disposed on a bottom surface of the plunger 415, and the kneading surface 420 is adapted to abut the mechanical link of a top surface of the assembly housing 255. Interface 545. In addition, the tip interface connector can be attached to a limited repeat assembly interface connector 553. When the tip section 205 is coupled to the finite overlap assembly 25 利用 in this manner, the actuator 515 and the actuator shaft 510 are adapted to drive the plunger 415 upwardly toward the needle 21 〇. Further, a 15-interface is formed between the controller 3〇5 and the temperature control device 45A. A signal Φ can be passed from the controller 3〇5 to the temperature control device 450 via the interface 535, the finite overlap assembly interface connector 553, the tip-interface connector 453, and the interface 530, when the tip region The controller 305 controls the operation of the actuator 515 when the segment 205 is connected to the finite overlap use assembly 25〇20. When the actuator 515 is actuated, the actuator shaft 510 is moved up to the needle 21A. In other words, the mechanical linkage interface 545 that is docked to the post interface 420 moves the plunger 415 upwardly toward the needle 210. A substance not placed in the dispensing chamber 405 is then ejected via the needle 21 0 0 16 200824739 In addition, the controller 305 controls the operation of the temperature control device 45A. The temperature control device is adapted to heat and/or cool the delivery chamber housing 425 and its contents. Because the dispensing chamber housing 425 is at least partially thermally conductive, heating or cooling to the housing 425 will heat or cool a product located in the dispensing chamber 4〇5. The temperature information can be transferred from the thermal shoulder paste back to the controller 305 via the interface 530, the tip interface connector, the finite overlap primary age connector 553, and the interface 535. This temperature information can be utilized to control the operation of temperature control device 450. When the temperature control unit 45 is a heater, the controller 3〇5 controls the amount of current sent to the temperature control unit 450. The greater the current delivered to the temperature control device 10 450, the hotter it becomes. In this manner, the controller can utilize the feedback from the thermal sensor 460 to control the operation of the temperature control device 450. Any suitable type of control algorithm, such as a proportional integral derivative (piD) controller, can be used to control the operation of temperature control device 450. Figure 6 is a cross-sectional view of a disposable tip section of an ophthalmic medical device in accordance with an embodiment of the present invention. In Fig. 6, the disposable tip section 205 includes a housing 215, a needle 210, a plunger 415, a plunger interface 420, a dispensing chamber 405, a dispensing chamber housing 425, an assembly 555, a temperature control device 450, and heat. Sensor 460, optional luer 430, tip interface connectors 451, 452 20 and 453, and interfaces 461, 462 and 463. The disposable tip section 205 functions as a disposable injection device. In the embodiment of Fig. 6, the plunger 415 is disposed in the delivery chamber housing 425. The delivery chamber 405 is surrounded by the delivery chamber housing 425 and the plunger 415. The plunger 415 is formed in fluid tight contact with one of the interior surfaces of the dispensing chamber housing 425. Needle 210 fluid type 17 200824739 Lightly coupled to delivery chamber 405. In this manner, a bag located in the dispensing chamber 405 can be contacted by the plunger 415 and pushed out of the needle 21 . The needle 21 can be secured to the disposable tip section 205 by a selective luer 430 and can be permanently attached. The temperature control device 450 is disposed on the dispensing chamber housing 425 and surrounds the dispensing chamber 405 at least in part. The housing 215 forms a skin on the disposable tip section 205. In various embodiments of the invention, the temperature control device 45 is a heating and/or a cooling device. The temperature control device 450 is in thermal contact with the dispensing chamber housing 425. Thus, the temperature control device 45 can change the temperature of the material in the dispensing chamber. In Fig. 6, the plunger 415 includes a loop. The annulus seal seals against an interior surface of the dispensing chamber housing 425. This side is used to maintain a sterile seal thus preventing contamination of the material dispensed into 405. The plunger 415 can be made of any suitable material such as glass 'stainless steel, or polymer. The G ring is usually made of rubber or polymerized: it can be sealed with other types. For example, the plunger 415 can include a _. The annular ring provided at the periphery of the post 415 causes the annular ring to contact the interior surface of the dispensing chamber 425. This annular ring holds the plunger (4) against the inner surface of the dispensing chamber. In this case, the residual ring can be made into a plunger and the plunger can be made of rubber or -polymer. The plunger interface 42A can be any suitable shape 20 . For example, the plunger interface can be substantially bowl-shaped as shown, or can be substantially flat w 13 cones, or faces. It may also include a lip or other type of structure. The tip interface connectors 451, 452, and 453 are used to provide a _ connection between the tip end sections 2 〇 5 fish and a limited repeat use assembly. Interface 461 connects thermal sensor 18 200824739 460 to tip interface connector 451. Interface 462 connects temperature control device 450 to k-tip interface connector 452. Interface 463 connects assembly 555 to tip interface connector 453. Assembly 555 can include any of a number of different components. In one embodiment, the 5 assembly 555 contains a fuse that is burned when the heated button is activated or the disposable tip section - 205 is used. In this manner, the fuse prevents the disposable tip section 205 from being used repeatedly. In another embodiment, the assembly 555 includes information relating to the type of disposable tip section 205, 'dose information, temperature information, plunger motion information, or for identifying the disposable tip section 2 A memory device of any other type of information for the operation of the 〇5 or the disposable tip section 205. In other embodiments, the assembly 2〇5 includes a hard-wired memory device such as a NAND flash 1C, an RFID tag, a hard-wired circuit that can store data representations, such as a series of dissolved wires in parallel. And resistors or other types of devices. A material that is normally delivered to the eye, which is a musical item, is placed in the dispensing Φ chamber 405. In this manner, the drug is contacted by the inner surface of the delivery chamber housing 425 and one side of the column-base 415. Temperature control device 450 is in thermal contact with dispensing chamber housing 425. In this manner, the temperature control device 45 is adapted to control the temperature of the contents of the dispensing chamber 405. In various embodiments of the invention, temperature control device 450 heats a phase change compound located in distribution chamber 40 5 . This phase change compound carries a drug that will be injected into the eye. A phase change compound is in a solid or semi-solid state at a lower temperature and a liquid state at a higher temperature. This material can be heated by a temperature control device 450 to a relatively liquid state and injected into the eye to form a 1928. For the same reason, an anti-gel compound can be used. - The reverse gelatinized mouth is in a solid or semi-solid state at a relatively local temperature and a ruthenium liquid state at a lower temperature. The compound can be cooled to a relatively liquid state by the temperature control device 450 and injected into the eye to form a large 5 pellet which erodes over time. The temperature control device 450 can be used to heat the distribution chamber 4〇5. A device of matter or a device (or a combination of both) for cooling a substance in the delivery chamber 405. After being delivered to the eye, a phase change compound or anti-gelling e-system provides a number of cockroaches during an extended period of time over time. A phase change compound or an anti-gel compound is used to provide a better drug dose with less injection. Thermal sensor 460 provides temperature information to assist in controlling the operation of temperature control device 450. The thermal sensor 46A can be placed proximate to the temperature of one of the dispensing chamber housing 425 and the metering proximity to the dispensing chamber housing 425. The thermal sensor 460 can also be configured to be in thermal contact with the dispensing chamber housing 425, which in this example measures a temperature of the dispensing chamber housing 15 425. In other embodiments, the temperature measured by thermal sensor 460 can be correlated to the temperature of the substance in delivery chamber 405. In other words, a temperature measurement of the dispensing chamber housing 425 can be used to calculate the temperature of the material in the dispensing chamber 405. Because the thermal characteristics of the dispensing chamber housing 425 and other materials are known, and the temperature of the temperature control device 450 can be controlled, applying 20 temperature control devices during a specified time period will result in a changeable calculation of one of the material temperatures in the dispensing chamber 405. . Thermal sensor 460 can be any of a number of different devices that can provide one of the temperature information. For example, thermal sensor 460 can be a thermocouple or a resistive device having a temperature varying resistance. In one embodiment of the invention, the substance located in the dispensing chamber 405 is a drug that is preloaded into the dispensing chamber by a 2008. In this case, the disposable tip zone slave 205 is suitable as a single use consumable product. This disposable product can be assembled in a factory with a dose of drug installed. When a drug is preloaded into the delivery chamber 405, a predetermined amount of the drug can be preloaded. For example, a 10 liter microliter of a drug can be loaded into the delivery chamber 405 and can be dispensed in any amount up to 1 microliter. Information about the amount of drug dispensed to 205 and other dose information can be stored in assembly 555. In this example, the plunger 415 can be moved a precise distance to deliver a precise dose of medication from the dispensing chamber 405 through the needle 21 and into one eye. This 10 provides dose flexibility and ease of assembly. Figure 7 is a cross-sectional view of a disposable tip section for an ophthalmic medical device in accordance with one embodiment of the present invention. In Fig. 7, the disposable tip section 205 includes a housing 215, a needle 210, a plunger 415, a plunger interface 420, a dispensing chamber 405, a dispensing chamber housing 425, an assembly 555, temperature control devices 450, 15 Thermal sensor 460, optional luer 430, tip interface connectors 452 and 453, interfaces 462 and 463, and lock mechanism 471. The embodiment of Figure 7 has the operation of the embodiment of Figure 6. The different components of the tip section 20 5 of Figure 7 have the same features and substantially the same operational style as the components of Figure 6. A lock mechanism 471 can be used to attach the tip section 205 to a limited reuse assembly. A docking mechanism, such as lock mechanism 265, on a reusable assembly is attached to lock mechanism 471 and secures tip section 205 to a limited reuse assembly. Figure 8 is a partial cross-sectional view of a finite overlap assembly and a cross-sectional view of a disposable tip section in accordance with an embodiment of the present invention. In Fig. 7, 21 200824739 disposable tip section 205 includes housing 215, needle 210, plunger 415, plunger interface 420, delivery chamber 405, delivery chamber housing 425, RFID target 1110, temperature control device 450, a tip interface connector 452, and an interface 462. A portion of the limited reuse assembly utilizes a mechanical linkage interface 545, an actuator 5 shaft 510, an interface 535, a finite overlap assembly interface connector 552, an RFID reader 1120, and an RFID interface 1130.

The embodiment of Figure 8 has the operation of the embodiment of Figures 6 and 7. The different components of the tip section 205 of Figure 8 have the same features and substantially the same mode of operation as the similar components of Figures 6 and 7. However, the embodiment of Figure 8 uses 10 an RFID system rather than a wiring assembly 555 to store and transfer information. The RFID reader 1120 is disposed proximate to the mechanical linkage interface 545, one of which finitely overlaps the use of the assembly top. The RFID tag is placed at the bottom of the tip section 205. The RFID reader 1120 is designed to read information from the RFID tag 1110. The RFID interface 1130 is coupled to a controller 305 (not shown). The RFID tag 1110 is configured to accommodate the same type of information that can be accommodated by the assembly 555 of the fifth to seventh embodiments. In this manner, the RFID tag 1110 is another type of memory. However, as is conventionally known, the RFID sample 1110 does not require a wire-type connection to one of the RFIDf purchasers 1120. In this manner, a wireless connection can be established between the tip section 205 (RFID tag 1110) and a limited reuse assembly 2 (RHD reader 1120). In one type of RFID system, i.e., a passive RHD system, the RFID tag 1110 does not have a power supply. Instead, the passive RFID tag relies on the electromagnetic field generated by the RFH) reader 1120 for its power. The electromagnetic field generated by the RFiD reader 1120 and the RFID reader antenna (not shown) induces a small current in the 22 200824739 RFID tag 1110. This small current can be tolerated ^^〗!) Tag 1110 operation. In this passive system, the RFID tag is designed to collect power from the electromagnetic field emitted by the RFID reader 1120 and to transmit an outgoing signal received by the rfID reader 1120. In a 5 operation, an RFID reader antenna (not shown) transmits a signal generated by the RFID reader 1120. An RFID tag antenna (not shown) receives this signal and induces a small current in the RFID tag 111 〇. This small current is still labeled φ 111 (H should be co-powered. The RFID tag 1110 can then send a signal via its rfid tag antenna to the RFID reader antenna and the rfid reader 1120 itself. In this way, the RFID tag The 1110 and RHD readers 1120 can be electrically coupled to each other on a radio frequency connection. The RF1D 1110 transmits information such as dose information or tip segment information to the RFID reader 1120 via the tag antenna. This information is received by the RFID reader 1120. In this manner, information can be transferred from the tip section to the limited repeat usage assembly. The RFID reader 120 can transmit information to the RFID tag 1110 in a similar manner 15. For example, the RFED reader 1120 can be in the RFID item. The RF signal transmitted by the 1120 sends a message such as dose information. The RFID tag 1120 receives the RF signal containing the information. & 1) The tag 1110 can then store the information. Although the embodiment of Figure 8 is described as having a system, any other type of wireless system can be used to transfer information between a limited reuse assembly 250 and the tip section 205. For example, a Bluetooth protocol can be used to establish a conduction connection between a limited reuse assembly 250 and a tip segment 2〇5, which can then be transferred to a limited reuse assembly on the conductive connection. 250 is between the tip end section 205. Other embodiments for transferring information 23 200824739 include an infrared protocol, 802.11, fire wire, or other wireless protocol. In one embodiment, the RFID tag 1110 (or assembly 555) contains dose information. Information about the appropriate medication dosage for the medication contained in delivery chamber 405 can be included on RFID tag 1110 (or assembly 555). In this example, controller 305 can read the dose information from RFID tag 111 〇 (or assembly 555) and operate actuator 515 in a manner suitable for delivering the appropriate dose. For example, 100 μl can be included in the distribution room 4〇5. Information may be stored on the RFID tag 1110 (or assembly 555) stating that 20 microliters of the dose is delivered to the eye. In this example, the controller 10 reads the dose information from the RFro tag 1110 (or assembly 555) (20 microliters should be delivered to the eye). Controller 305 can then operate actuator 515 to deliver a 20 microliter dose. Controller 305 can cause actuator 515 to move actuator shaft 510 and mechanical linkage interface 545 a set distance associated with a 20 microliter dose. In this example, the plunger 415 is moved by this set distance so that only 20 microliters of the drug is ejected from the needle 15 210 and enters one eye. In another embodiment consistent with the principles of the present invention, controller 305 can calculate the distance a plunger 415 must move to deliver the desired dose. For example, if the dose information corresponding to 20 microliters of the drug dose is read from the RFID tag 111 (or assembly 555) by the controller 305, the controller 305 can use the resource 20 to calculate that the plunger 415 must be moved. An appropriate distance. Because the volume of the dispensing chamber 4〇5 and the volume of one of the medications loaded in the dispensing chamber 405 are known, the controller 305 can calculate the distance that the plunger 415 must be moved to deliver the desired dose. When the dispensing chamber 405 has a cylindrical shape, the cross-sectional area of the cylinder (and a circular area) can be multiplied by the height of the dispensing chamber to calculate the volume of the dispensing chamber. This simple mathematical formula can be used to calculate the total volume of the delivery chamber 405. Because the cross-sectional area of the dispensing chamber 405 is constant for any given application, the height corresponding to the travel distance of the plunger 415 can be calculated for any dose amount. For example, it is assumed that 100 microliters of drug is loaded into the delivery chamber 405 and the cross-sectional area of the dispensing chamber 5〇5 is ten. When the dispensing chamber 405 has a cylindrical shape, the height of the cylinder is also 10. In order to deliver a 20 microliter dose corresponding to 20% of the total volume of the dispensing chamber 405, the plunger 415 is moved up to the needle 210 to a distance of two. In other words, a 20 microliter dose corresponds to 20% of the total volume of the dispensing chamber 405. In this example, the plunger 415 should be moved upwardly toward the needle 210-segment by a distance equal to 20% of the total height of the dispensing chamber 405. The controller 305 can then control the actuator 515 such that the actuator shaft 510 moves the plunger 415 upward by a distance of 20% of the total height of the dispensing chamber 405. Additionally, controller 305 can read information about the rate at which plunger 415 should be moved to properly deliver a dose of medication. In this example, controller 3〇5 I5 reads information about the drug delivery rate from RFID tag 1110 (or assembly 555) and uses this information to operate actuator 515 to drive plunger 415 at that rate. The rate at which the plunger 415 moves can be fixed or variable. In some applications, it may be desirable to move the plunger 415 faster than in other applications. For example, when the drug contained in the delivery chamber 405 is a drug that should be heated prior to injection into the eye, it may be desirable to drive the plunger 415 at a rate such that the heated drug does not cool and clog the needle 210. In other applications, it may be desirable to slowly move the plunger 415 to improve delivery of a drug in the dispensing chamber 405. RFID 1110 (or assembly 555) may also include any other type of information regarding a drug delivery. For example, the RFID tag 111 (or assembly 555) may include 25 200824739 information about the type of drug contained in the delivery chamber 405, the different characteristics of the drug, or an appropriate dose or other characteristics of the (four)-transfer . In addition, the RFID tag m〇 (or the assembly sister) may contain security information, information about the appropriate operation of the tip area & 205, and any other information about the tip section or the limited repeating assembly. In another embodiment, which is presented in the principles of the present invention, a dose can be selected by a medical professional who administers the drug. In this example, an input device (not shown) disposed on the limited reuse assembly 250 or tip section 2〇5 allows the physician to select the desired dosage of the drug. In this example, the controller 3〇5 ίο receives the desired drug dose and operates the actuator 515 to move the plunger 415 a desired distance to deliver the desired dose. This user-selectable dosing regimen can be implemented simply by adding an additional input device. Month b hopes to include a sword amount on the RFID target 111〇 (or assembly 555) so that the dose error is less likely to occur. In this example, several different medications 15 delivery tip sections 205 may be manufactured and loaded with a drug at the factory. Dosage information can also be loaded on the RFID tag 1110 (or assembly 555) at the factory. In this example, a plurality of different tip segments each containing the same amount of drug in the dispensing chamber 405 but having different dose information stored on the RFID tag 1110 (or assembly 555) can be manufactured and shipped. The physician can then order the tip section 205 with the desired dose information on the RFID tag 111 (or assembly 20 555). The package can be clearly labeled to identify dose information such that the appropriate dose is administered to a patient. Figure 9A is a cross-sectional view of a disposable tip section for an ophthalmic medical device in accordance with one embodiment of the present invention. In Fig. 9, the disposable end section 205 includes a housing 215, a needle 210, a plunger 415, a plunger shaft 417, a 26200824739 column base interface 420, a delivery chamber 405, a delivery chamber housing 425, and an assembly 555. The temperature control device 450, the thermal sensor 460, the optional luer 430, the tip interface connection states 452 and 453, the interfaces 462 and 463, and the Tibetan sheets 472 and 473. The non-word component of the tip section 2〇5 of Fig. 9 has the same features and the same operation mode as the class 5 components of Figs. The embodiment of Figure 9 includes two signatures 472 and 473 for engaging a slot in a finite overlap assembly. After the two tabs 472 and 473 are inserted into the slot, the tip assembly 205 is rotated by φ to lock it in a position on a limited re-use assembly. The two signatures 472 and 473 may be of different shapes or sizes to provide a suitable interface between the tip end section 2〇5 and the limited repeat 10 use assembly. When the two tabs 472 and 473 have different shapes or sizes, the tip section 405 is only mated to a limited repeating assembly. In other embodiments of the invention, different shapes or sizes of tabs can be used with different shapes or sizes of slots on different limited repetitive use assemblies. In this manner, a number of different finite overlaps can be used to accommodate a plurality of slots of different shapes or sizes to accommodate tip segments 205 having complementary shapes or dimensions φ. Further, the embodiment of Fig. 9 includes a plunger shaft 417 coupled to the plunger 415. In this embodiment, the plunger 415 can be molded over the plunger shaft 417. The plunger shaft 417 has a cylindrical shape and has 20 diameters smaller than its distal and proximal ends. The plunger interface 42 is embodied as one of the surfaces on the proximal end of the plunger shaft 417. The plunger shaft 417 is typically fabricated from a rigid material such as stainless steel. The plunger 415 is made of a rubber or polymer material. In another embodiment of the invention, the distal end of the plunger shaft 417 has a lip to which the plunger 415 can be applied. The plunger 415 can be press fit into the plunger shaft 417 and held in position by a lip 27 200824739 on the distal end of the plunger shaft 417. This allows for easier assembly. If the plunger 415 is not molded on a shaft, the plunger 415 can be formed as a separate portion and pushed onto the distal end of the plunger shaft 417. The plunger interface 420 can have any suitable shape. Figure 9B is an end view of the tip section of Figure 9A. 9B is the farthest from the tip of the needle. This end forms an interface with a finite overlap assembly. Housing 215, plunger interface 420, tip interface connector 45, 452, 453, 454, 455 and 456, tabs 472 and 473, and alignment slot 481 are depicted. In the embodiment of Fig. 9B, one end of the plunger interface 420 is not completely rounded. It has a flat portion that is designed to align with a mechanical linkage interface having a similar cross-sectional shape. This optional feature is designed to allow a tip end section and a finite overlap assembly to be properly aligned. In other embodiments of the invention, the cross-sectional view of the 420 end of the plunger interface is circular. The embodiment of Figure 9B also includes an optional alignment slot 481 to assist in properly aligning a 15 tip section with a limited repeat use assembly. The alignment slot 481 forms an interface with an alignment pin (shown as 581 in Fig. 11) on a finite overlap assembly. In an embodiment of the invention, the signatures 472 and 473 have different sizes. Or the 'tags 472 and 473 can have different shapes. The two tabs 472 and 473 also assist in aligning the tip end section 2〇 with a limited repetitive use assembly by forming an interface with the slots 572 and 573 of Fig. 11. In one embodiment consistent with the principles of the present invention, a tip end section is placed over a limited reuse assembly to allow the tabs 472 and 473 to be inserted into slots 572 and 573. The tip section is then rotated relative to the finite overlap using assembly such that the tabs 472 and 473 are held in slots 572 and 573. Alignment pin 581 and alignment slot 200824739 481 are then properly aligned. Connectors 451, 452, 453, 454, 455 and 456 electrically connect a tip end section to a limited repetitive use assembly. Connectors 451, 452, 453, 454, 455, and 456 form interfaces with similar connectors 5 551, 552, 553, 554, 557, and 556, respectively, on a finite overlap assembly (as shown in Figure η). These connectors provide a path for signals to pass between a tip end section and a finite overlap assembly. The brothers 10A-10D are diagrams of four different circuits that can be included in an embodiment of the present invention. Figure 10A shows one of the more than 10 different configurations for temperature control device 450. In Fig. 10A, temperature control device 450 is coupled to connectors 452 and 455. Power and/or control signals are provided to temperature control device 450 via connectors 452 and 455. FIG. 10B shows one of many configurations for thermal sensor 460. In Fig. 10B, thermal sensor 460 is coupled to connectors 451 and 454. Signals are received from thermal sensor 460 via connections 451 and 454. Figure 10C shows one of many different configurations for a fuse 1011. Fuse 1011 can be included in assembly 555 or can be implemented as shown in Figure lc. In Fig. 10C, the fuse 1011 is connected between the connectors 453 and 456. In this embodiment, the fuse 1011 is used to ensure that the tip end body is a single use device. The fuse 1011 is burned out when the heating button is activated or after the disposable tip section 205 is used. As described above, a control 1 in a finite overlap assembly detects when the connected tip section has been used and directs an increased current through the fuse 1011 to thereby burn the fuse. When the fuse 1011 is burned, the tip section is no longer operational and must be disposed of. 29 200824739 The i〇d diagram shows the many configurations for the assembly 555. In the figure, assembly 555 is coupled to connectors 453 and 456. Power and/or control signals are provided to assembly 555 via connectors 453 and 456. Many other configurations of connectors 451, 452, 453, 454, 455, and 456 are possible. For example, although six connectors are shown, any number of connectors can be implemented. Also, any combination of different circuits may be included in a tip section. Figure 11 is an end view of the finitely repetitive use assembly of the panel in accordance with one or more principles of the present invention. The end of the finite overlap assembly shown in Fig. 11 forms an interface with the end of the tip assembly shown in Fig. 9B. The end view of the finite overlap use assembly depicted in FIG. 11 shows the housing 255, the mechanical linkage interface 545, the finite overlap assembly interface connector 55, 552, 553, 554, 557, and 556, slots 572, and 573. And alignment pin 581. In the embodiment of Fig. 11, one end of the mechanical linkage interface 545 is not completely 15 _. It has a flat portion designed to be aligned with a plunger interface having a similar cross-sectional shape. This optional feature is designed to allow proper alignment of a tip end section and a finite overlap assembly. In other embodiments of the invention, a cross-sectional view of one end of the mechanical linkage interface 545 is circular. The embodiment of Fig. 11 also includes an optional alignment slot 581 to assist in properly aligning a 20 tip section with a finite overlap assembly. The alignment pin 581 forms an interface with the alignment groove on the tip end section (481 shown in the ninth off). In other embodiments of the invention, slots 572 and 573 have different sizes. Alternatively, slots 572 and 573 can have different shapes. The two slots 572 and 573 also assist in the alignment of the tip end region 30 200824739, 5 segments with a limited repetitive use assembly by forming interfaces with the tabs 472 and 473 of the tip segment shown in the figures. Connectors 551, 552, 553, 554, 557 and 556 electrically connect a tip section to a finite overlap assembly. Connectors 551, 552, 553, 554, 557 and 556 form an interface with connectors 451, 452, 453, 454, 455 and 456 on a tip end section (as shown in Figure 9B). These connectors provide a path for signals to pass between a tip end section and a finite overlap assembly. Figure 12 is a cross-sectional view of a finite overlap use assembly in accordance with one embodiment of the present invention. In Fig. 12, the finite overlap assembly 250 includes a mechanical 10 link interface 545, an actuator shaft 510, an actuator 515, a power source 505, a controller 305, a finite overlap assembly housing 255, an interface 535. The finite overlap uses the assembly interface connector 55, the displacement sensor 1215, the power source controller 444, and the inductive component 1225. 15 • Displacement sensor 1215 measures the motion of actuator shaft 510. The displacement sensor may be an optical rotary encoder, a linear encoder, a current sensing circuit (Hall sensor), a rotary potentiometer, or a linear potentiometer, and others. In other embodiments, the displacement sensor can detect if the actuator 515 is malfunctioning. For example, a Hall sensor can detect an increase in current draw by one of the actuators 515, which indicates a fault condition. The displacement sensor 1215 can also measure the back electromotive force from the 20 actuator 515. Displacement sensor 1215 can comprise a single component or multiple components. In one embodiment consistent with the principles of the present invention, the displacement sensor 1215 includes a means for measuring the travel distance of the actuator shaft 510 and a means for detecting if the actuator 515 is malfunctioning. Displacement sensor 1215 measures the position of actuator shaft 510. Because the mechanical linkage 31 200824739 rod interface 545 is coupled to the actuator shaft 510, the displacement sensor 1215 also measures its position. This displacement sensor 1215 can be used to determine whether or not to deliver a complete dose. If the displacement sensor 1215 detects that the actuator shaft 510 has moved a particular distance corresponding to the movement of the mechanical linkage interface 545 and the plunger 415, it is known that a particular dose has been expelled from the 5-needle 210. In the case of delivering a drug to the eye, the 'displacement sensor 1215 provides information about the movement of the actuator shaft 510, which can be used to determine if a full dose has been delivered. In some cases, the actuator 515 may be malfunctioning, so the actuator shaft 5!, the mechanical linkage interface 545, and the plunger 415 cannot be driven at an appropriate distance to deliver a full dose of the drug to one eye. In this example, displacement sensor 1215 measures the distance that actuator shaft 510, mechanical linkage interface 545, and plunger 415 have moved. The amount of drug delivered can be calculated from this distance information. For example, when the distribution to 405 is cylindrical, the cross-sectional area is known. The distance measured by the displacement sensor 1215 then becomes a cylinder height, and the capacitance of the displacement can be easily calculated (e.g., by controller 305). This amount of conveyance can be turned on via an indication such as display 320 connected to the same item (Fig. 3). Displacement sensor 1215 may also provide additional information useful in the drug delivery process. For example, when the tip end section is coupled to a finite overlap use assembly, the actuator shaft 510 can be withdrawn or brought to a home position for attachment to a 20 tip section. Displacement sensor 1215 can measure the motion of actuator shaft 51 〇 to this home position. The actuator shaft 510 can be placed in a home position to allow a tip section to be attached to a limited reuse assembly or prior to delivery of a medicament. In one embodiment, prior to actuation of the actuator 515 to deliver a drug to the eye, information read from the displacement sensor 1215 can be utilized to confirm that the actuator 32 200824739 shaft 510 is in a home position. The embodiment of Fig. 12 also includes a power source controller 444 and an inductive component 1225. When the power source 505 is, for example, a rechargeable battery, the two components control the charging of the power source 5Ό5. The power source controller 444 includes circuitry that can perform any of a number of different functions related to charging, monitoring, and maintaining the power source 5〇15. In other implementations, power source 444 can be implemented or integrated into controller 305. Φ In one embodiment of the invention, power source controller 444 (or controller 305', as the case may be) counts the number of times that the finite reuse assembly 25 has been used. After the count reaches a predetermined number of safe uses, the limited repeat use assembly 250 is released. Alternatively, power source controller 444 (or controller 3〇5, as the case may be) counts the number of times power source 505 has been charged (the number of charging cycles that power source 5〇5 has withstood). When the count reaches a predetermined low limit, the limited repeat use assembly 250 is released. In other embodiments of the invention, power source controller 15 444 (or controller 305, as the case may be) detects a failure condition # or other unsafe condition of power source 505 and prevents further use of limited reuse assembly 250. To charge the power source 505, a stream of electricity 20 is induced in the inductive element 1225 when placed in proximity to another inductive component in a charging substrate (not shown). This induced current charges the power source 505. Figure 13 is a cross-sectional view of a finite overlap use assembly in accordance with one embodiment of the present invention. In FIG. 12, the finite overlap assembly 250 includes a mechanical linkage interface 545, an actuator shaft 510, an actuator 515, a power source 505, a controller 305, a finite overlap assembly housing 255, and an interface 535. Finite repeat 33 200824739 The assembly interface connector 55 is used to displace the sensor, the power source controller 444, and the charging contact 1235. In the embodiment of Figure 13, the contact portion forms a interface with a contact on a charging substrate (not shown) to provide power to the power source 5〇5. In an embodiment 5, the contact portion I235 is a USB type connection used by a portable electronic device such as a docking station. In one embodiment, a M〇lex®CmdleConTM connector is employed. Other types of connectors are also available. 14 and 15® are cross-sectional views of two assemblies in accordance with the principles of the present invention. These secondary assemblies each trace the path from actuator 515 to needle 21〇. Figure 10 14 depicts a mechanical linkage interface 545 rigidly coupled to the actuator shaft 510, while Figure 15 depicts a mechanical linkage interface 545 having a ball joint 8〇5. The ball joint 805 can be used to assist the mechanical linkage interface 545 in alignment with the plunger interface 420. In Fig. 14, the actuation 515 has an actuator shaft 51 that is rigidly coupled to the mechanical linkage interface 545. The mechanical linkage faces the plunger interface 420. The column base 415 is disposed in the delivery body 425 and seals against an inner side surface of the delivery chamber housing 425. The dispensing chamber 405 is bordered by an interior surface of the dispensing chamber housing 425 and a distal surface of the plunger 415. The temperature control device 45 is at least partially surrounding the dispensing chamber housing 425. The needle 210 is fluidly coupled to the dispensing chamber 4〇5. In the Figure 15, the actuator 515 has an actuator shaft 510 that is coupled to the shaft 810 by a ball joint. Mechanical linkage interface 545 is rotatably coupled to shaft 810 via ball joint 805. The mechanical link faces the plunger interface 42〇. The plunger 415 is disposed within the dispensing chamber housing 425 and seals against an inner side surface of the dispensing chamber housing 425. The dispensing chamber 405 is bordered by an interior surface 34 200824739 of the dispensing chamber housing 425 and the distal face of the plunger 415. The temperature control device 45 is at least partially surrounding the dispensing chamber housing 425. The needle 210 is fluidly coupled to the dispensing chamber 4〇5. In Figs. 14 and 15, the actuator 515 drives the actuator shaft 51 upward (in a direction toward the needle 210). In other words, the mechanical linkage interface 545 is also driven upward by 5. When the mechanical linkage interface 545 is docked to the plunger interface 420, the plunger 420 is also moved upward. A substance enclosed in the dispensing chamber 4〇5 is driven out through the needle 210. In this manner, motion and force are transferred from the actuator shaft 51 to the mechanical linkage interface 545 to the plunger 415. When the dispensing chamber 405 contains a drug to be delivered to one eye, the configuration of Figures 14 through 15 eliminates backflow when the needle is removed from the eye. The action of the plunger 415 is in a single direction (the direction in which the drug in the delivery chamber 405 is driven out). When the mechanical linkage interface 545 is moved in a direction away from the needle 210, such as after the drug has been injected into the eye, the plunger 415 remains in position. Because the plunger 415 is not rigidly coupled to the mechanical linkage interface 545, the plunger 415 is not retracted when the mechanical linkage interface 15 545 is retracted. Figure 16 is a cross-sectional view of the finite overlap assembly and a charging substrate of Figure 13. In Fig. 16, a bottom surface of the finite overlap assembly 250 forms an interface with the charging substrate 1615. When the limited reuse assembly 250 rests in the charging substrate 1615, the power source 505 can be charged. After being charged, the limited 20-reuse assembly 25 can be removed from the self-charging substrate 1615. In one embodiment of the invention, a limited reuse assembly 250 having an attached tip end section 205 is placed in the charging base 1615 and the substance in one of the dispensing chambers 405 is heated or cooled by the temperature control device 450. . In this manner, the charging substrate 1615 provides power for the temperature control device 450. When the substance in the dispensing room 405 35 200824739 * 5 has reached an appropriate temperature (as determined by information from the thermal sensor 460), the limited reuse assembly 250 having the attached tip end section 205 can be used. The self-charging substrate is removed. This saves power source 505 for the injection process when the limited repetitive use assembly 250 and the attached tip end section 205 are removed from the charging substrate 1615. 17A and 17B are flow diagrams of a method for injecting a substance into an eye in accordance with one of the principles of the present invention. In 1705, a tip segment is identified and a connection between the finitely repeated assemblies is used. In the 1710th, the type of tip segment connected to the finite overlap use assembly is identified. For example, a 10 drug delivery tip segment or drug delivery tip segment type can be identified. This identification can occur by reading information from the tip section, such as by reading information from the memory 4RFn) tag. In 1715, dose information is received from the tip end section. As with the information on the type of tip segment, the dose information can be read from a memory device in the tip end section 15 by a controller, RFID reader, or similar device in the finite overlap assembly. In Φ - 20 2020, a temperature control device is activated to change the temperature of the substance in the delivery chamber. The substance can be heated or cooled as previously described. In addition, heating or cooling may occur only when the tip end section and the limited repeat use assembly are on a filling substrate. In 1725, temperature information is received from a thermal sensor that is close to the dispensing chamber in which the substance is placed. In 173, this temperature information is used to control the temperature control device to regulate the temperature of the substance. In 1735 the 'actuator shaft is moved to a home position. For example, the shaft has been reinstated to establish a home position. The home position can establish a reference point for one of the displacement sensors. In other words, the displacement sensor can start 36 200824739 Measure the movement of the actuator shaft from the home position. 174〇 Ancient Actuator shaft movement 5

It is heated or cooled as it is on the charging substrate. When the tip section and the limited re-use assembly are removed from the charging substrate, the physician may have a limited period of time to perform the injection before the material temperature falls outside the temperature range. The mechanical link interface (which is integral with or connected to the actuator shaft) is brought into contact with the plunger interface. In this position, any advancement of the actuator shaft: causes the object f to be driven from the dispensing chamber. When the mechanical link interface contacts the sister-side device, the substance can be injected into the eye. This step occurs when the substance is administered to the eye at a suitable temperature for injection prior to injection into the eye. For example, the substance can be injected in a short period of time in the tip section and the money reuse assembly = mechanical link interface to the plunger interface.

In 1745, an input is received to indicate that the item will be delivered to the eye. For example, the physician can press a button to send a signal to the controller 15 to indicate that the actuator will be actuated to deliver the substance. In 1750, dose-corruption is used to control the operation of relay H to deliver the appropriate dose at an appropriate rate. The shell is delivered to the eye only after it is in the proper temperature range. In 1755, the self-displacement sensor receives information. This message indicates that the actuator shaft has been in action for you. The distance the actuator shaft has moved is associated with a dose. As the shaft has moved 2, the larger the plunger has been displaced, and the greater the dose delivery. In 1760, & indicates the indication of the delivered dose. For example, it can be indicated by a green light or a quantity (in microliters representing the amount of material delivered) - wherein a successful injection of a full dose has been successfully delivered. In an unsuccessful injection, the actual delivered material is shown. In 1765, for example, by burning a fuse in the tip section, 37 200824739 is used to re-use the tip section. Figure 18 is a flow chart showing a method of injecting a substance into the eye in accordance with one of the principles of the present invention. Figure 18 depicts a method of initiating a temperature control device to reduce and cool the material located in the dispensing chamber while the tip section and the finite overlap are used to locate the assembly in the charging station. Delete, identify the tip end segment "limited connection using one of the assemblies. In the 181〇, identify the type of the tip segment. In 1815, the dose information is received from the tip segment. In 1820, the tip is determined. Whether the end segment and the finite overlap assembly are on the charging substrate. If it is not on the charging substrate, the system waits and returns to W plus in 1825. 10 Right tip segment and limited reuse On the charging substrate, in 183, the temperature control device is activated to change the temperature of the substance contained in the distribution chamber. In 1835, the temperature information is received from a thermal sensor. In the 184, the temperature is utilized. Information to control the temperature control device. Figure 19 is a flow chart of a method for injecting a substance into a 15 eye in accordance with one of the principles of the present invention. Figure D depicts a method for determining whether a suitable animal agent has been delivered. The actuation is controlled based on a dose rate information. The actuator moves the plunger to rotate the substance. In 1920, the self-displacement sensor receives information indicating that the actuator shaft has moved. 193 Use 'this distance information to decide No. An appropriate dose has been delivered. If the 2 actuator shaft has moved the distance required to deliver the appropriate dose, then in 1940, an indication is given that one of the appropriate doses has been delivered. If the actuator shaft has not moved to deliver the appropriate dose, Distance, then in 1950, the delivered dose is calculated based on the distance the actuator shaft has moved. In 1960, an indication of one of the delivered doses is provided. 38 200824739 Figure 20 is directed to injecting a substance to one of the principles of the present invention. Flowchart of the method in Figure 20. Figure 20 shows the situation in which the actuator shaft has failed: In 2010, the actuator is controlled based on the 'dose and dose rate information. The actuator moves the plunger to deliver the substance. In 2020, the data is received from π 5 from a fault. In 2030, the data is used to determine that the actuator shaft is not faulty. If the shaft has failed, in 2040, one of the fault conditions is provided. A private sensing person receives information indicating the movement distance of the actuator shaft 2060, and provides one of the delivered doses based on the distance information indicating that if the shaft has not been faulty, then in 2070, a proper delivery has been provided. Indicative of Quantity 10 From the above, it will be appreciated that the present invention provides an improved system and method for delivering a precise volume of a substance to an eye. The present invention provides a single-use, disposable type capable of delivering a precise dose. The tip end section of the delivery device. The tip section forms an interface with a finite overlap assembly. The invention is exemplified herein and can be modified differently by those skilled in the art. 15 Although it is a single use of the music conveying device The present invention is described in the context of any single embodiment of the present invention. The specification and the implementation of the invention disclosed herein will be apparent to those skilled in the art. The example is intended to be only as follows: The true scope and spirit of the present invention is defined by the scope of the patent application. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a perspective view of a prior art syringe; FIG. 2 is an eye including a disposable tip section and a finite overlap assembly according to an embodiment of the invention Fig. 3 is a diagram of a finite overlap using assembly according to the principles of the present invention. 200824739 " 5 • An embodiment; FIG. 4 is a finite repetitive use according to one of the principles of the present invention. A cross-sectional view of another embodiment of the present invention; FIG. 5 is a cross-sectional view of a disposable tip section and a finite overlap assembly according to an embodiment of the present invention; FIG. 6 is a cross-sectional view of a finite overlap assembly according to the present invention; One embodiment of a disposable cross-sectional view of a disposable tip section for an ophthalmic medical device; FIG. 7 is a disposable tip section for an ophthalmic medical device in accordance with an embodiment of the present invention; Cross-sectional view; 10 Figure 8 is a cross-sectional view of a disposable tip section and a partial view of a finite overlap assembly in accordance with an embodiment of the present invention; Figure 9A is a diagram in accordance with the present invention. One of the embodiments is for an ophthalmic medical device A cross-sectional view of the disposable tip section; Figure 9B is an end view of the embodiment of Figure 9A; 15 • Figures 10A-10D are four different circuits that can be included in an embodiment in accordance with the invention schematic diagram. Figure 11 is an end view of a finite overlap assembly in accordance with the principles of the present invention, and Figure 12 is a cross-sectional view of a finite overlap using a total of 20% according to an embodiment of the present invention; A cross-sectional view of a finite overlap assembly using one of the embodiments of the invention; Figures 14 and 15 are cross-sectional views of two assemblies in accordance with the principles of the present invention; 40 200824739 Figure 16 is a finite weight in accordance with the principles of the present invention A cross-sectional view of a cover assembly, a tip section, and a charging substrate; FIGS. 17A and 17B are flow diagrams of a method for injecting a substance into an eye in accordance with one of the principles of the present invention; A flow chart of a method of injecting a substance into an eye in accordance with one of the principles of the present invention, and FIG. 19 is a flow chart showing a method of injecting a substance into an eye in accordance with one of the principles of the present invention; One of the principles of the invention relates to a flow chart of a method of injecting a substance into a 10 eye. [Main component symbol description] 105,210···Needle 275...Selective lighting 110···Lou hub 305...Controller 115···室306,307···Indicator 120,415···Plunger 308...button 125,417...column The plug shaft 320...the display 130...the thumb rest 330...the housing 205···the tip end section 340...the limited use of the end of the assembly 215···the tip section housing 405...the distribution chamber 250...limited Repeated use of assembly 420...Plunger interface 255···Limited reuse assembly housing 425...Distribution chamber housing 260...Threaded portion 430...Selective Luer 265, 47l···Lock mechanism 444...Power Source controller 270...switch 450...temperature control device 41 200824739 451,452,453,454,455,456 ...tip 1110...RFID tag end interface connector 1120...RFID reader 460···thermal sensor 1130...RFID interface 461,462,463,517,530,535...interface 1215 Displacement sensor 472, 473... signature 1225... inductive element 481... alignment slot 1235... charging contact 505... power source 1615... charging base 510... actuator shaft 1705, 1710, 1715, 1720, 1725, 515... actuator 1730...Step 545...Mechanical linkage interface 1735, 1740, 1745, 1750, 1755, 551, 552, 553, 554, 556, 557 ... with 1760, 1765... steps limited to use assembly interface connectors 1805, 1810, 1815, 1825, 1830, 555... Assembly 1835, 1840...Steps 572, 573 ... slots 1910, 1920, 1930, 1940, 1950, 581... Alignment pins 1960... Step 805... Ball joints 2010, 2020, 2030, 2040, 2050, 810 · · · Shaft 1011... Fused Wire 2060, 2070...Step 42

Claims (1)

200824739 X. Patent Application Range: 1. A method for delivering a substance to an eye, comprising: identifying a connection between a tip end section and a finite overlap assembly; from the tip section Receiving dose information; initiating a temperature control device to change a temperature to be delivered to a substance in one eye; receiving temperature information from a thermal sensor; using the temperature information to control the temperature control device; receiving an indication The substance is to be delivered for input; and based on the dose information, the actuator is controlled to move a plunger to deliver the substance. 2. The method of claim 1, wherein the method further comprises: providing an indication that the substance has been successfully delivered. 3. The method of claim 1, wherein the receiving the dose information from the tip end segment further comprises: reading the dose information from an RFID tag. 4. The method of claim 1, further comprising identifying a type of the tip segment connected to the limited reuse. 5. The method of claim 1, further comprising: receiving dose rate information from the tip section. 6. The method of claim 5, further comprising: controlling the actuator to move a 43 200824739 plunger to deliver the substance based on the dose rate information. 7. The method of claim 1, wherein controlling the actuator to move a plunger to deliver the substance further comprises: calculating the actuator must move the actuator shaft to deliver a distance of an appropriate dose. 8. The method of claim 1, wherein controlling the actuator to move a plunger to deliver the substance further comprises calculating a rate at which the actuator must move the actuator shaft to deliver a The appropriate dose. 9. The method of claim 1, wherein a temperature control device is activated to modify a temperature system to be delivered to a substance in one eye when the limited reuse assembly and the tip segment are disposed in Upon charging the substrate, and further comprising the charging substrate providing power to the limited reuse assembly, the provided power is used to activate the temperature control device. 10. The method of claim 1, further comprising: identifying that the tip section and the finite overlap assembly have been placed on a charging substrate; and wherein a temperature control device is activated to cause the change to be delivered to A temperature of one of the substances in a glance occurs when the tip end section and the limited repeat use assembly are disposed on the charging substrate. 11. The method of claim 1, wherein controlling the actuator to move a plunger to deliver the substance further comprises: moving the actuator shaft to a home position; and moving the actuator shaft to A mechanical link interface is brought into contact with a plunger 44 200824739 interface. 12. The method of claim </ RTI> wherein the controlling the actuator to actuate a plunger to deliver the substance further comprises: (2) moving the actuator shaft to a home position; Prior to the eye, the actuator shaft is moved to bring a mechanical linkage interface into contact with a plunger interface; and after the substance has reached the appropriate temperature, the actuator is activated to move the plunger to deliver the substance to In the eye. The method of claim 1, further comprising: receiving, from a displacement sensor, information indicating a distance that the actuator axis has moved. 14. The method of claim 13, further comprising: providing an indication of the delivered dose based on the distance. The method of claim 1, further comprising: • receiving, from a fault sensor, information indicating that the actuator has failed. The method of claim 15, wherein the method of claim 15 further comprises: “providing an indication of a fault condition. 17. The method of claim 1, further comprising: providing the substance that has been successfully delivered An indication of the quantity. 18. The method of claim 1, further comprising: preventing the repeated use of the tip section. 19. A method for delivering a substance to an eye, comprising: a connection between the tip section and a finite overlap assembly; 45 200824739 identifying a type of tip section connected to the finite overlap assembly; receiving dose information from the tip section; a temperature control device for modifying a temperature to be delivered to a substance in one eye; receiving temperature information from a thermal sensing; using the temperature information to control the temperature control device; moving the actuator axis to a return a starting position; before the substance is injected into one eye, the actuator shaft is moved to bring a mechanical link interface into contact with a plunger interface; receiving a means for indicating that the substance is to be Input; after the substance reaches an appropriate temperature, the dose information is used to control the actuator to move the plunger to deliver the substance to an eye; received from a displacement sensor for indicating that the actuator shaft has Moving a distance data; and providing an indication of the delivered dose based on the distance. 20. The method of claim 19, further comprising: providing an indication that the substance has been successfully delivered. The method of claim 19, wherein receiving the dose information from the tip end section further comprises: reading the dose information from an RFID tag. 22. The method of claim 19, further comprising: The end segment receives the dose rate information. 23. The method of claim 22, further comprising: 46 200824739 based on the dose rate information 'control the actuator to move a plunger to deliver the substance. Patent Application Serial No. 19, wherein controlling an actuator to move a plunger to deliver the substance further comprises: calculating an actuation The actuator must be displaced by the actuator shaft to deliver a distance of a suitable dose. The method of claim 19, wherein the controlling the actuator to move a plunger to deliver the substance further comprises: calculating a rate The actuator must move the actuator shaft at this rate to rotate a suitable dose. 26. The method of claim 19, wherein a temperature control device is activated to modify a substance to be delivered to one of the eyes. A temperature system occurs when the limited repetitive use assembly and the tip section are disposed in a charging substrate. 27. The method of claim 19, further comprising: identifying the tip section and limited The repetitive use assembly has been placed on the charging substrate; and a temperature system in which a temperature control device is activated to modify a substance to be delivered to one of the eyes occurs when the tip end section and the limited repetitive use total When disposed on the charging substrate, and the progress includes providing the charging substrate to provide power to the limited reuse assembly, the provided power is used to activate the temperature control device. 28. The method of claim 19, further comprising: receiving information from a fault sensor indicating that the actuator has failed. 29. The method of claim 28, further comprising: 47 200824739 providing an indication of a fault condition. 30. The method of claim 19, further comprising: providing an indication of the amount of the substance that has been successfully delivered. 31. The method of claim 19, further comprising: preventing repeated use of the tip section. 48