200808261 九、發明說明： L啦明所屬之技術領域】 本發明是有關於主要為靜脈學領域的光動力組成物， 特別是有關於光動力雷射處理以消除靜脈曲張、網狀靜脈 以及物蛛網靜脈等，而不需要沿著被處理的靜脈麻醉。 【先前技術】 靜脈曲張是-種在全世界常見的症狀，影響多達6〇% 、斤有年長者4寸別地’尤其是年長女性，她們可能比男 性更可能會有這個問題。 人們想矯正靜脈擴張的渴望有醫學及心理學二者的美 礎。靜脈曲張可引起疼痛及不舒服。有時症狀會導致更： 重：健康問題。靜脈曲張也可能顯示其他循環系統疾病的 更高風險。此外’在腿上的靜脈曲張是特別令人心煩的， 並且阻礙許多人公開暴露這些症狀。 靜脈曲張的徵兆及徵候可包括腿部的疼痛或壓迫感， 以及灼熱、心悸、肌肉痙攣及下肢腫脹。1時間的坐或站 會有使腿部感覺惡化的傾向。這可能導致在一條或多條靜 脈周圍的經常性發癢；接近腳踝處可能的皮膚潰爛，其代 表血管疾病的嚴重形式，並且需要立即的注意。靜脈曲張 的顏色為暗$色或藍色’並且可能呈現扭曲及凸起—像是 在繩索中的結。匕們通常出現在下肢的背側或腿部的内侧 上。但疋它們可在腿部，從鼠蹊到腳踝的任何地方形成。 蜘蛛網靜脈類似於靜脈曲張，但它們是較小的。蜘蛛 網#脈被發現杈靠近皮膚表面’並且顏色通常是紅色或藍 6 200808261 色。它們在腿部上出現，但也可在臉部及鼻子上被發現。 虫知蛛網靜脈的大小會改變，並且通常看起來像是㈣ 樹枝。 其他類型的靜脈曲張包括；為在靜脈中的血液池之靜 脈湖，通常是在臉部及頸部域發現。網狀靜脈是在皮膚 下方的平坦藍色靜脈，並且通常出現在膝蓋後方。毛細管 擴張是類似於蜘蛛網靜脈的血管細微叢集，顏色為淡紅 色，並且通常在臉部或上半身被發現。偶爾，在腿部内深 處的靜脈會變得擴大。在這樣的例子中，受影響的腿部可 能相當地腫脹，並且可能或可能不會伴隨疼痛及紅色。這 確定要有緊急醫療注意’因為它可能代表血塊――種醫學 上已知為血栓性靜脈的症狀。 歷史上，已開發不同的方法用以處理這個問題，以及 人們每年花費數十億元以除去靜脈曲張。除去靜脈曲張的 第-個處理是硬化治療，並且在二十世紀初期，手術是除 去靜脈曲張最好的方法。一種相當新的發展是内血管雷射 手術（ELVeSTM)，並且是取代手術的有效方法。在硬化 治射，程序涉及到將硬化難㈣使靜脈結㈣小型或 中型靜脈㈣内。這個方法關閉了靜脈，迫使血液改變路 線至較健康的靜脈。在六週或七週内，處理的靜脈曲張應 該會逐漸消失。雖然相同的靜脈可能需要注射超過一次， 但如果正確進行的話’硬化治療通常僅在小靜脈中有效。 此外’ 一種稱為微-硬化治療的雜从^ y 縻的新的改善類型的硬化治療係 使用改善的溶液及注射技術’其增加除去场蛛網靜脈的成 7 200808261 功率。硬化治療不需要一私 、隹…… &的麻醉’並且可在醫師診間中 進仃，僅要處理區域的局部麻醉。 ]r 用於處理靜脈曲張的一些程序如下·· (1) 導管協助程序··在土含^老 ^ 4 ^ 在绝個處理中，醫師將細管（導 、:）插入擴大的靜脈内，並將導管的尖端加熱。隨著導管 ^ ^ . . *封關閉處而破壞靜脈。 這個程序通常是對較大的靜脈曲張進行。其他導管協助方 法係使用刀片破壞靜脈曲張， 閉。 /使用無線電波將它們關 (2) 靜脈剝離：這個程序涉及到經由兩個小切口除 士-條長的靜脈。將靜脈結紮，並且藉由將其拔出而除去:、 攻個方法需要一般麻醉以及住 且會留下傷苑。 “長的恢復期’並 :3)走動式靜脈切除術：醫師經由—系列微小的皮 ;二而除去較小的靜脈曲張。在這個門診程序中使用局 4麻醉。傷疤一般是最小的。 晚期㈣靜脈手術：這個程序在涉及腿部潰瘍的 偷？疋必要的。這個手術使用薄型攝影機插入腿 以使猙脈成像並且關閉靜脈。僅需要小的切口。 (5)雷射手術是用於隔離較小的靜脈曲張及蜘蛛網 ^合特別是在上半身及臉部。過去，在腿部中的靜脈曲 S致地對雷射處理有反應’特別是較大的靜脈，以 ^分醫師質疑雷射手術是否確實有作用。然而，現在雷 '處理的新技術可利用内血管雷射靜脈系統ELVeS，而有 8 200808261 效地處理在腿部中的靜脈曲張。在這個程序中，係施加局 部麻醉，並且將光學纖維插入靜脈内。有效的雷射輻射， 通常是980 nm、930 nm或81〇 nm的輻射，隨著抽回光學 纖維而將熱能施加到靜脈，導致靜脈關閉，而靜脈最後經 由吸收而消失。 在皮膚表面下的雷射處理也已在Trelles等人的美國 專利第5,578,029 ?虎中說明。該專利說明一種方法，藉此 將光學探針插入與血管異常相鄰的皮膚。導入雷射脈衝將 提供靜脈萎縮及隔離。這個方法需要沿著所要的靜脈多次 插入裝置以處理異常，因為探針是垂直插入到靜脈軸所 致。這個程序有其限制。首先，所說明的方法是特別對於 靜脈的處理，主要是在腿部，因此是限制在該特定的處理。 其次，該程序需要低功率的光束以照明及引導探針到皮膚 下的處理部位。則處理限制在照明光束可穿透的深度之^ 膚下部位。第Z ’該方法說明將雷射功率傳遞至需要處理 的靜脈之鄰近處及外部。因此，對於使用者而言，要在手 邊擁有不同應額需的所有各種大小探針可能是困難的； 並且要得到額外的附加裳置對他們而言可能是昂貴的。其 次，用於處理的特殊探針太昂貴以致於不能丟棄；、因此了 它們在施用之後必需消毒以及削尖。這對於使用者而今是 既耗費時間又麻煩的。為了確保每個探針都適當地消主， 時間及努力是必要的；並且適#的削尖係取決於使用:的 謹慎及技巧而定。這樣的雷射處理是藉由使靜脈 隔離靜脈，是一種間接的解決方法。 、、、 9 200808261 這個方法也需要將裝置多次、插入患者的皮膚内。每次 的插入都必須進行，以使探針被放置在靠近要處理的靜脈 的附近。將所處理的靜脈片段隔離，將裝置移除，再次插 入靜脈的另一片段，並且重複此慢吞吞的程序。這個需求 使得裝置更難以使用。此外，藉由導入多次的皮膚穿孔， 感染的風險會增加，正如皮膚表面毁損的機會。 另一個處理靜脈曲張的例子是由Del Gigli〇的美國專 利第6,200,332號所說明。Del Giglio的裝置容許每個處理 的結構之簡單、單一的插入以及特定的雷射傳遞。將針插 入血管結構中，以及將從來源開始且持續到整個結構的任 何異常都根除。第三，當與1射線成像偶聯時，本發明可 用於處理各種身體内部的結構，例如，在手術期間。射 線成像容許使用者在身體結構内將裝置定位。雷射傳遞處 理可接著如上述說明而投予。 本發明的目標是提供一種可安全及有效處理皮膚下異 =的方法及裝置，而不會引起與先前技術有關的問題及有 口田丨作用。此外，本發明也致力於提供一種光敏化劑及成 刀的新組成物，其特別適合於例如處理皮膚下異常的醫療 應用。 【發明内容】 本Ιδ月的個目標是要滿足有效光處理的需求，其可 用於以更大的專一性及效率以及最小的侵入性而根除血管 異常。 本叙月的另一目標是提供一種靜脈曲張硬化症處理之 10 200808261 方法’其對於附屬於隱靜脈及網狀靜脈直徑約2 mm或更 小的基本上扭曲的靜脈曲張是更有效的。 本1明的另一目標是提供一種將可與靜脈中的光動力 硬化症組成物起作用之方法。 本lx明的另一目標是提供一種用於光動力治療處理的 光敏化劑泡沫調配物，特別是用於血管及其他皮膚下異常 的處理。 簡口之本叙明說明用於最小侵入的、多方面適用且 知確的活體内光處理之光動力組成物及方法。本發明提供 僅、最v插入，通常是單一插入處理區域的光處理。本發 明可與標準的插人組件—起使用，使系統變得便宜，且容 易t、面師使用。本發明可應用在許多的處理領域。美學皮 膚瑕疲如靜脈曲張的活體内處理可以最小的外部影響進 7。將狀量的光動力組成物以料形式注射到所關心的 Λ或、α構内組成物是一種包含光敏化劑的硬化症泡 沫：藉由外部的壓縮，如果適合的話，迫使光動力組成物 较只邊在评脈或結構内。在預定的時間之後，將得自光源 ㈣當波長的輻射直接傳遞至金管結構。本發明重要的好 處是消除起定的靜脈曲课r，& Τ + 1 靜脈曲張而不需要沿著靜脈長度麻醉； 沒有水腫；沒有皮膚反應；以及觸覺認可。 本么月上述及其他目標、特徵及優點，將從以下結合 附圖解釋的說明而變得明白， 欠付月曰附圖中，在不同圖式中的同 樣昝考標號代表同樣項目。 【實施方式】 200808261 特別地，許多女性在她們的一生中某些時候患有、已 患有或將患有靜脈曲張。它是—種美容病理學，並且具有 重要的病理學一般内涵。 一般而言，這是屬於大部分女性的問題，以及通常是 在至4〇歲之間的女性，特別是在生完小孩之後；從荷 爾豕的觀點，延是導源於雌激素及黃體酮的增加，其降低 血官順應@ ’特別是在不具有已完善定義的肌肉壁之靜脈 中。在這種狀況下，靜脈會更有與擴張的管壁入逑的傾向， 卫且¥致砰脈曲張。此外，擴大的子宮也會壓縮骨盆靜脈， j且減少好的血液回流，將額外的壓力置於下肢靜脈上。 14個擴張也會導致靜脈曲張。 :脈曲張會引起腿部美學的改變，以及這會改變人類 仃…特別是女性。有女性因為腿部靜脈曲張的原因， 因此而不去海灘或不穿短裙。 =沒有適當可靠的解決方法，僅有一般而言不會達到 70全滿意的醫療、機能及化妝處理。 一本發明有關於處理靜脈曲張的目標是要：⑴提供 種除去大塊靜脈曲張的醫 先前被硬)提供用於破壞 欠的内皮細胞及肌肉層之方法；以及 靜脈曲曰張口。吞。巫細胞及多形核白血球的到達，以最終除去 ^ (1? " t(T;moporfin} ^ ^ ^ ^ ^ 其可扮、、寅怀*nm ’舌化日”這會產生細胞内的氧化作用， 貝修改細胞膜性質、細胞質、核糖體、高基氏體及 12 200808261 細胞核的角色，最終啟動一系列結果是細胞凋亡的事件。 當暴露至替莫泊吩的作用時，細胞開始一系列的形態 變化。漿膜改變並且出現特有的起皰疹。細胞體積相當程 度地減少’且細胞質濃縮。細胞核變得較小，以及染色質 變得較緻密，最終崩解，分裂成許多的有形球體。 在細胞〉周亡的最後，細胞是藉由吞噬作用而被吞噬細 胞或鄰近細胞所攝入，避免在壞死中的發炎反應。即使細 胞消失’但膠原蛋白網仍有增加。這改善膠原蛋白的支撐、 膠原蛋白纖維及彈性蛋白的重新校準；減少基礎細胞間物 質的凝膠黏稠度；改善氧合作用及細胞營養；以及減少毒 性代謝物的停留及水腫。 替莫泊吩是一種非常有效的活化三重態氧之光化學產 生劑，其不需要大劑量的藥物以殺死細胞，也不需要長期 暴露於光。 在光動力的方法中，活化的替莫泊吩在氧的存在下產 生1)瞵間咼氧合作用並且增加靜脈内皮破壞。這會增 加靜脈萎縮以及主要的阻礙；2)由於快速形成的主要阻 礙而減少血液傳染及微凝塊停留；3)在7到丨〇天產生纖 、隹、、且織以製造更堅固的皮膚結構，因此最終的硬化症是在 、工本务明處理之後不超過2丨天結束；4 ) pMN在身體將靜 脈曲張偵測為外來物體之前到達，以及最終的纖維消除是 早成且完全的。 相外部特徵使得這個處理對於靜脈曲張的醫療根除是理 心的§患者拒絕手術時，這些典型地使得這個治療選項 13 200808261 對於大塊靜脈曲張方面是理想的。 這個方法在實際實施時是相當簡單易懂的。將蝴蝶針 用於靜脈曲張的渠道化，並且緩慢導入光動力組成物。在 瓖光動力組成物進入靜脈壁的大約1 5分鐘的短時間之後， 將能量密度約20-28焦耳/平方公分的雷射輻射施加到該區 域0 第1圖說明替莫泊吩在活化之後交互作用的過程，導 致為壁細胞膜表面及細胞核、粒腺體、高基氏體、内質網 及核糖體改變原因之細胞内氧化作用，其導致細胞的死亡 或細胞调亡。 曰莫泊吩在黑暗中是完全不活性的，並且是以低強度 的光使之活化，而將其轉變成強力的分離氧產生劑。 如第2A至2C圈所觀察到的，硬化治療是從注射藥物 開始（第2A H) ’該藥物可將靜脈曲張的壁轉形為纖維 索（第2B圖）。在大約45天之後纖維索消失（第2C圖）。 硬化泡沫（SF )是-種具有表面活性性質的氣體與液 體溶液之混合物；氣泡大小較佳應在丨〇〇 #以下。泡、未在 靜脈内形成黏著性丸塊，其阻止藥物與血液的任何混合。 由於增加靜脈曲張内膜的破壞以及背部結疤索所致， 光動力硬化症組成物/泡沫（PDSF)增加壁轉形成纖維索。 利用光動力硬化泡珠（PDSF)，在靜脈内可有藥物濃 度的完全控制，在硬化作用劑與内皮間的改善接觸時間痕 增加的内膜破壞，以及更快速地將靜脈曲張轉形成纖維索 及其之後藉由吞噬作用的消除。 β ” 14 200808261 广永久性加速消除，已 醫療用泡沫的開發是由一 ⑽⑽於1993年所門* 班牙血官外科醫師“ ^ 年所開始，他提出由聚十二醇（或十二烷 基聚乙二醇羥基聚乙氧一 土卞一烷）（POL· )所組成的 ^療用泡沫於靜脈曲張處理的用$。這是在表面靜脈不全 之處理方面的真正邁進。在1997年，施in MGnf猶報導 -種利用玻璃注射器及無菌栓塞以產生微弱泡珠的技術。 Patnck Benigni及Sym〇n Sad〇un以可抛棄式注射器及塞子 產^ POL泡珠。在1999年’ Ming〇_Garcia報導另一種利 用乳及特殊設計的施用泡沫裝置的技術。在2〇⑻年， Lorenz。Tessari呈現他的三向塞子技術其可以極低的成 本立即製備非常優異的泡床。為了製備Tessad氏的泡珠， 需要三向活栓，其與填《i毫升藥物的2 5毫升注射器及 真充4至5笔升大氣空氣的5毫升注射器連結。進行2〇 次快速的溶液通過。在前10次的通過之後，將塞子盡可 能地變窄。這將形成高品質及高黏稠性的泡沫。 使用光動力硬化症泡沫的本發明，將〇 5至】5體積 %的小量POL與50%的葡萄糖溶液及存在於微脂體溶液 中的50至1〇〇 ng/ml替莫泊吩（光敏化劑）摻合。葡萄糖 改善泡沫的黏稠性，並且大幅增強活化的光敏化劑纖維索 之形成。微脂體及純的替莫泊吩都已在泡沫組成物/調配物 中製備。先前技藝間接預期該等泡沫將難以穩定地形成， 200808261 因此用於光動力治療可能充其量是最低限度的。 硬化泡沫及光動力硬化泡床： 硬化治療是注射可將靜脈曲張壁轉形成纖維索的藥 物。硬化治療的端點應該是永久性的閉塞，但這不是一直 會發生在液體硬化劑。不足的硬化治療之主因是由$中藥 物將被稀釋之血液體積以及其產生效果的快速性所代表。 閾值水平時或如果有最低有幻農度達—段充分的時間，硬 化症才會被引發。 利用液體硬化劑，在靜脈部分内的注射將内部的藥物 濃度提升至最高點，然後是血液稀釋，以及内部硬化劑濃 度的相當快速下降。曲線的形狀是由注射速度、注射體積 與血管大小的比例及血流所支配。只有在出現藥物濃度的 在毛細管擴張中，我們可以預期筆直的上升以及相當 長的穩定期，只有在那個時候藥物才會出現在毛細管擴張 的内部。 在具有明顯倒流之大型大隱靜脈（Gsv)中，最高點 將比先前的例子慢達到，並且將與針的大小及注射物質的 流動性有關。在該靜脈部分中，硬化劑的最大濃度將與硬 化劑會被稀釋的血㈣積有關。這可解釋為什麼硬化治療 在對毛細管擴張的藥物效力方面從未有問冑，以及為什麼 隱靜脈硬化症一直以來總是難以達到。 當注射泡沐時，它會在靜脈内部形成黏著性丸塊。由 ;匕的I·生貝所致，這個丸塊具有受控制且一致的性質，因 此可在原位被控制—段時間。這將導致最適的硬化症，且 16 200808261 對於第一次而言，將導致受控制的硬化症。 泡珠是氣體氣泡在相當小體積液體（其包含界面活性 二：1丄t面活性劑））中的非平衡分散液。這些優先吸 ” a液體界面，並且是液體轉換成泡沫的 產”散液的穩定性之原因。硬化泡珠是一種具有表= 陳貝的乳體與液體溶液之混合物，以及氣泡大小較佳岸 在100//m以丁 水、 平乂狂應 — §注射時，硬化泡沫的運轉狀態與液體 溶液的作用是X η Μ 〃 疋不冋的。活性物質POL·及替莫泊吩具有更多 時間接觸内膜饍jgf主 、脈表面。不僅光動力作用更強烈，並且疏 水性的光敏化劑替莫泊吩也能在硬化作用之後穿透更深 :所由於4些因素，最後的清潔劑使内皮經由受細胞表面 ::的干擾而受損。清潔劑纟1秒的暴露内會引起内皮的 、…也間的膝結物質被瓦解，引起内皮細胞的脫皮。 ”光敏化劑替莫泊吩受益於這個作用，以在内皮中穿透 木層’並將其置於剛好接近靜脈的肌肉層。當替莫泊吩 U光t射而活化時’它在氧的存在下產生將導致細胞破 乂勺車乂回之问氧合作用，並且經由纖維母細胞而立即開始 、截、准母細胞可如纖維母細胞對於内化學因子般多 的内部分化及增殖而增加。 用泡/末取常見的錯誤是將它視為單一的實體。事實 上根據所選擇的方法，可能產生具有不同特性、併發症 j及/σ療適應症之非常不同的泡沫。我們可藉氣泡直徑 而將泡朱分類（"+、、办 Q大/包沬、泡沫、小泡沫及微泡沫），或藉 由液體的相剩· I f y ’ I形狀是表面張力與界面力之間競爭的結 17 200808261 果）而將泡沫分類為濕泡沫（幾乎球形的氣泡—潮濕，或 液體的體積分率超過5% )。濕泡沫顯示於第3A圈。乾泡200808261 IX. INSTRUCTIONS: TECHNICAL FIELD OF THE INVENTION The present invention relates to photodynamic compositions mainly in the field of venography, in particular to photodynamic laser treatment to eliminate varicose veins, reticulated veins and cobwebs. Intravenous, etc., without the need to be anesthetized along the treated vein. [Prior Art] Varicose veins are common symptoms in the world, affecting up to 6%, and older people are 4 inches apart, especially older women, who may be more likely than men to have this problem. The desire to correct venous dilatation has the beauty of both medicine and psychology. Varicose veins can cause pain and discomfort. Sometimes symptoms can cause more: Weight: Health problems. Varicose veins may also present a higher risk of other circulatory diseases. Furthermore, varicose veins on the legs are particularly annoying and prevent many people from publicly exposing these symptoms. Symptoms and signs of varicose veins may include pain or pressure in the legs, as well as burning, palpitations, muscle spasms, and swelling of the lower extremities. Sitting or standing for one time has a tendency to deteriorate the feeling of the legs. This may result in frequent itching around one or more veins; possible skin ulceration near the ankle, which represents a serious form of vascular disease and requires immediate attention. The color of the varicose veins is darker or blue and may appear to be distorted and raised—like a knot in a rope. They usually appear on the dorsal side of the lower limbs or on the inside of the legs. But they can be formed anywhere in the leg, from the groin to the ankle. Spider veins are similar to varicose veins, but they are smaller. The spider web # is found to be close to the skin surface' and the color is usually red or blue 6 200808261 colors. They appear on the legs but can also be found on the face and nose. The size of the spider's veins changes, and usually looks like (four) branches. Other types of varicose veins include; the quiescent lake of the blood pool in the vein, usually found in the face and neck regions. The reticular vein is a flat blue vein below the skin and usually appears behind the knee. Capillary expansion is a subtle cluster of blood vessels similar to a spider vein, colored reddish, and usually found on the face or upper body. Occasionally, veins deep in the legs become enlarged. In such an example, the affected leg may be quite swollen and may or may not be accompanied by pain and red. This is determined to have urgent medical attention 'because it may represent a blood clot - a medically known symptom of a thrombotic vein. Historically, different methods have been developed to deal with this problem, and people spend billions of dollars each year to remove varicose veins. The first treatment to remove varicose veins was sclerotherapy, and in the early twentieth century, surgery was the best way to remove varicose veins. A fairly new development is the Internal Vessel Laser Surgery (ELVeSTM) and is an effective alternative to surgery. In the sclerotherapy, the procedure involves hardening the hardened (four) venous knots (four) within the small or medium veins (four). This method closes the vein and forces the blood to change the route to a healthier vein. The treated varicose veins should gradually disappear within six or seven weeks. Although the same vein may require more than one injection, 'sclerotherapy is usually only effective in the venules if done correctly. In addition, a new and improved type of sclerotherapy treatment called micro-sclerotherapy treatment uses an improved solution and injection technique to increase the power of the removal of the field spider vein into 7 200808261. Sclerotherapy does not require a private, sputum & anesthesia and can be administered at the physician's office, with only local anesthesia in the area being treated. ]r Some procedures for treating varicose veins are as follows: (1) Catheter assisted procedure ·· In the soil containing ^^^^^ In the absolute treatment, the physician inserts the thin tube (guide, :) into the enlarged vein, and Heat the tip of the catheter. The vein is broken as the catheter ^ ^ . . * closes the closure. This procedure is usually performed on larger varicose veins. Other catheter assist methods use a blade to break varicose veins and close. / Use radio waves to turn them off (2) Venous dissection: This procedure involves removing the strip-length vein through two small incisions. The vein is ligated and removed by pulling it out: The method of attack requires general anesthesia and living and will leave a wounded garden. "Long recovery period" and: 3) Walk-on venous resection: The physician removes the smaller varicose veins via a series of tiny skins; in this outpatient procedure, the local anesthesia is used. The scars are generally the smallest. (iv) Venous surgery: This procedure is necessary for theft of leg ulcers. This procedure uses a thin camera to insert the leg to image the vein and close the vein. Only a small incision is required. (5) Laser surgery is used for isolation Smaller varicose veins and spider webs are especially in the upper body and face. In the past, the varicose veins in the legs responded to the laser treatment, especially the larger veins. Whether the surgery really works. However, the new technology of Ray's treatment can use the internal vascular laser system ELVeS, while there are 8 200808261 to effectively treat the varicose veins in the legs. In this procedure, local anesthesia is applied. And inserting optical fibers into the vein. Effective laser radiation, usually 980 nm, 930 nm, or 81 〇nm radiation, applies thermal energy to the vein as the optical fiber is withdrawn, resulting in The vein is closed, and the vein eventually disappears through absorption. Laser treatment under the surface of the skin has also been described in U.S. Patent No. 5,578,029, to Trelles et al., which describes a method whereby an optical probe is inserted into a blood vessel. Abnormally adjacent skin. Introducing a laser pulse will provide venous atrophy and isolation. This method requires multiple insertions along the desired vein to handle the anomaly because the probe is inserted vertically into the venous axis. This procedure has its limitations. First, the method described is particularly for vein treatment, mainly in the leg, and is therefore limited to this particular treatment. Second, the procedure requires a low power beam to illuminate and direct the probe to the treatment site under the skin. The treatment is limited to the area under the depth at which the illumination beam can penetrate. The third '' method indicates that the laser power is transmitted to the vicinity of the vein to be treated and externally. Therefore, for the user, It may be difficult to have all the various sizes of probes on hand to have different requirements; and to get extra additional skirts for them It can be expensive. Secondly, the special probes used for processing are too expensive to be discarded; therefore, they must be sterilized and sharpened after application. This is both time consuming and cumbersome for the user. To ensure that each The probes are properly dissipated, time and effort are necessary; and the sharpening of the # depends on the care and skill of the use: such laser treatment is by indirect vein separation, is an indirect The solution. , , , 9 200808261 This method also requires the device to be inserted into the patient's skin multiple times. Each insertion must be performed so that the probe is placed close to the vein to be treated. The vein segment is isolated, the device is removed, another segment of the vein is reinserted, and the sluggish procedure is repeated. This requirement makes the device more difficult to use. In addition, by introducing multiple skin perforations, the risk of infection increases, just as the skin surface is damaged. Another example of the treatment of varicose veins is illustrated by Del Gigli, U.S. Patent No. 6,200,332. Del Giglio's devices allow for simple, single insertion and specific laser delivery of each processed structure. The needle is inserted into the vascular structure and any abnormalities that begin from the source and continue throughout the structure are eradicated. Third, when coupled with 1-ray imaging, the present invention can be used to treat various internal structures of the body, for example, during surgery. Radiographic imaging allows the user to position the device within the body structure. The laser delivery process can then be administered as described above. SUMMARY OF THE INVENTION It is an object of the present invention to provide a method and apparatus for safely and efficiently treating subcutaneous hypothyroidism without causing problems associated with prior art and having an effect on the sputum. Furthermore, the present invention is also directed to providing a photosensitizer and a new composition for forming a knife which is particularly suitable for, for example, medical applications for treating abnormalities under the skin. SUMMARY OF THE INVENTION The goal of the present invention is to meet the needs of effective light processing, which can be used to eradicate vascular abnormalities with greater specificity and efficiency and minimal invasiveness. Another goal of this semester is to provide a venous variceal treatment 10 200808261 method which is more effective for substantially distorted varices adjacent to the saphenous vein and reticulum veins having a diameter of about 2 mm or less. Another object of the present invention is to provide a method of acting with a photodynamic sclerosis composition in a vein. Another object of the present invention is to provide a photosensitizer foam formulation for photodynamic therapy treatment, particularly for treatment of blood vessels and other subcutaneous abnormalities. This is a description of the photodynamic compositions and methods for minimally invasive, versatile and identifiable in vivo light processing. The present invention provides light processing that is only the most v-inserted, typically a single insertion processing region. The present invention can be used with standard plug-in components to make the system cheaper and easier to use. The invention is applicable to many fields of processing. In vivo treatment of dermatophytes such as varicose veins can have minimal external influences. Injecting a quantity of photodynamic composition into the Λ or α composition within the composition of interest is a sclerosis foam containing a photosensitizer: by external compression, if appropriate, forcing the photodynamic composition to be more Only in the evaluation of the pulse or structure. After a predetermined time, the radiation from the source (4) is transmitted directly to the gold tube structure. An important benefit of the present invention is the elimination of a defined venous course r, & Τ + 1 varicose veins without anesthesia along the length of the vein; no edema; no skin reaction; and tactile recognition. The above and other objects, features and advantages of the present invention will become apparent from the following description taken in conjunction with the accompanying drawings. In the drawings, the same reference numerals in the different drawings represent the same items. [Embodiment] 200808261 In particular, many women have, have or will have varicose veins at some point in their lives. It is a kind of cosmetic pathology and has an important general connotation of pathology. In general, this is a problem for most women, and is usually between women up to 4 years of age, especially after the birth of a child; from the perspective of Horqin, the extension is derived from estrogen and progesterone The increase in blood lowering compliance @ 'especially in veins that do not have well defined muscle walls. Under this condition, the vein will have a tendency to enter the sputum with the dilated wall, and the sputum will cause varicose veins. In addition, the enlarged uterus compresses the pelvic veins, reducing the return of good blood and placing additional pressure on the veins of the lower extremities. 14 expansions can also lead to varicose veins. : The varicose veins will cause changes in the aesthetics of the legs, and this will change the human cockroaches... especially women. There are women who have varicose veins in their legs, so they don't go to the beach or wear short skirts. = There is no adequate and reliable solution, and generally only 70, fully satisfactory medical, functional and cosmetic treatments will not be achieved. One object of the invention relating to the treatment of varicose veins is to: (1) provide a method for removing large varicose veins that has previously been hardened to provide for destruction of underlying endothelial cells and muscle layers; and varicose veins. swallow. The arrival of witch cells and polymorphonuclear white blood cells, in order to finally remove ^ (1? "t(T; moporfin} ^ ^ ^ ^ ^ which can be played, 寅怀*nm 'lingual day" will produce intracellular oxidation Role, Bay modified cell membrane properties, cytoplasmic, ribosomal, high-kilth and 12 200808261 cell nucleus role, and finally initiated a series of events that are apoptotic events. When exposed to temoport, the cells begin a series of Morphological changes. The serosa is altered and a characteristic herpes is present. The cell volume is considerably reduced' and the cytoplasm is concentrated. The nucleus becomes smaller, and the chromatin becomes denser, eventually disintegrating and splitting into many tangible spheres. At the end of the death, the cells are ingested by phagocytic cells or adjacent cells by phagocytosis, avoiding the inflammatory reaction in necrosis. Even if the cells disappear, the collagen network is still increased. This improves the support of collagen. Recalibration of collagen fibers and elastin; reduction of gel consistency of basic intercellular substances; improvement of oxygenation and cellular nutrition; and reduction of toxicity Staying and edema of metabolites. Temoporte is a very effective photochemical generator that activates triplet oxygen, which does not require large doses of drugs to kill cells and does not require long-term exposure to light. In the method, activated temopophene produces 1) dioxane oxime oxygenation and increases venous endothelial destruction in the presence of oxygen. This increases venous atrophy and major obstruction; 2) reduces blood due to major obstacles to rapid formation Infection and microclay retention; 3) Fiber, sputum, and weaving are produced in 7 to 丨〇 days to produce a stronger skin structure, so the final sclerosis is not more than 2 days after the treatment ;4) pMN arrives before the body detects varicose veins as foreign objects, and the final fiber elimination is early and complete. The external features make this treatment a rational treatment for the venous varicose veins § patients refused surgery These typically make this treatment option 13 200808261 ideal for large varicose veins. This method is fairly straightforward to implement in practice. The butterfly needle is used for the channelization of varicose veins and slowly introduces the photodynamic composition. After a short time of about 15 minutes into the vein wall, the energy density is about 20-28 joules per square centimeter. Radiation is applied to this region. 0 Figure 1 illustrates the interaction of temotope after activation, resulting in intracellular cell membrane surface and intracellular, granulocyte, high-kilth, endoplasmic reticulum and ribosome changes in the cell. Oxidation, which leads to cell death or apoptosis. 曰Mobote is completely inactive in the dark and is activated by low-intensity light, which is converted into a powerful separation oxygen generator. As seen in the 2A to 2C circle, the sclerotherapy is initiated from the injection of the drug (2A H) 'The drug can transform the wall of the varicose vein into a fiber cord (Fig. 2B). The fiber rope disappeared after about 45 days (Fig. 2C). The hardened foam (SF) is a mixture of a gas having a surface-active property and a liquid solution; the bubble size should preferably be below 丨〇〇 #. The foam does not form an adhesive mass in the vein, which prevents any mixing of the drug with the blood. The photodynamic sclerosis composition/foam (PDSF) increases wall-forming to form a fiber cord due to increased destruction of the varicose inner membrane and back chordae. Using photodynamically sclerosing beads (PDSF), there is complete control of drug concentration in the vein, improved intimal destruction between the hardening agent and the endothelium, and more rapid conversion of varicose veins into fiberoptic cords. And then by the elimination of phagocytosis. β ” 14 200808261 Wide permanent acceleration elimination, the development of medical foam has been started by a (10) (10) in 1993, according to the Department of Blood, the official of the Department of Health, he proposed by polydodecanol (or dodecane The therapeutic foam consisting of poly(ethylene glycol hydroxypolyethoxy oxonate) (POL·) is used for the treatment of varicose veins. This is a real step forward in the treatment of superficial venous insufficiency. In 1997, Shi MGnf reported on the use of glass syringes and sterile embolization to produce weak beads. Patnck Benigni and Sym〇n Sad〇un produce POL beads with disposable syringes and stoppers. In 1999, Ming〇_Garcia reported another technique for the use of milk and specially designed foaming devices. In 2 (8) years, Lorenz. Tessari presents his three-way plug technology, which immediately produces very good blister beds at very low cost. In order to prepare Tessad's beads, a three-way stopcock is required, which is linked to a 25 ml syringe filled with i ml of drug and a 5 ml syringe filled with 4 to 5 strokes of atmospheric air. Perform 2 快速 rapid solution passes. After the first 10 passes, the plug is narrowed as much as possible. This will result in a high quality and highly viscous foam. In the present invention using a photodynamic sclerosis foam, 〇5 to 5% by volume of a small amount of POL and a 50% glucose solution and 50 to 1 ng/ml of temobot (presented in a lipophilic solution) The photosensitizer) is blended. Glucose improves the viscosity of the foam and greatly enhances the formation of activated photosensitizer fibers. Both liposomes and pure temopophen have been prepared in foam compositions/formulations. Previous art indirectly expects that such foams will be difficult to form stably, 200808261 so that photodynamic therapy may be minimal at best. Hardened foam and photodynamically sclerosing blister: Sclerotherapy is the injection of a drug that converts the varicose wall into a fiber cord. The endpoint of the sclerotherapy should be permanent occlusion, but this does not always occur with liquid sclerosing agents. The main cause of inadequate sclerotherapy is represented by the volume of blood that the Chinese medicine will be diluted and the rapidity of its effects. Hardening can only be triggered at the threshold level or if there is a minimum period of time. With a liquid hardener, injections in the venous portion raise the internal drug concentration to the highest point, followed by blood dilution, and a fairly rapid decrease in internal hardener concentration. The shape of the curve is governed by the rate of injection, the ratio of injection volume to vessel size, and blood flow. Only in the presence of drug concentration in telangiectasia, we can expect a straight rise and a fairly long stabilization period, only when the drug appears inside the telangiecton. In large saphenous veins (Gsv) with significant backflow, the highest point will be slower than in the previous example and will be related to the size of the needle and the fluidity of the injected substance. In this vein portion, the maximum concentration of the hardener will be related to the blood (four) product in which the hardener will be diluted. This may explain why sclerotherapy has never been questioned about the efficacy of drugs for telangiectasia, and why saphenous vein sclerosis has always been difficult to achieve. When injected, it forms an adhesive mass inside the vein. This pellet is controlled by a sputum, which has a controlled and consistent nature and can therefore be controlled in situ for a period of time. This will result in optimal sclerosis, and 16 200808261 for the first time will result in controlled sclerosis. The beads are non-equilibrium dispersions of gas bubbles in a relatively small volume of liquid containing interfacial two: 1 丄t surfactant. These preferentially absorb the "a liquid interface and are the result of the stability of the liquid which is converted into a foam". The hardened bead is a mixture of a milk and a liquid solution with a table = Chen Bei, and the bubble size is preferably at 100//m in water, and the sputum is mad- § when injected, the working state of the hardened foam and the liquid The effect of the solution is X η Μ 〃 疋 疋. The active substance POL· and temopophen have more time to contact the endometrial diet jgf main, pulse surface. Not only is the photodynamic effect more intense, but the hydrophobic photosensitizer temopophen can also penetrate deeper after hardening: due to four factors, the final detergent causes the endothelium to be affected by cell surface:: damage. In the exposure of the detergent for 1 second, the endothelium, ... also the knee joint material is disintegrated, causing the skin cells to peel off. "The photosensitizer temopophene benefits from this effect, penetrating the wood layer in the endothelium and placing it in the muscle layer just in close proximity to the vein. When temoport is activated by t-light, it is in oxygen In the presence of the cell, the cell will be broken and the oxygen will be used, and the fibroblast will start immediately, and the truncated and quasi-mother cells can be as internal and differentiated as the inner chemical factor of the fibroblast. The common mistake with blister/end is to treat it as a single entity. In fact, depending on the method chosen, very different foams with different characteristics, complications, and/or sputum indications may be produced. Sorting the bubble by the diameter of the bubble ("+, Q big/package, foam, small foam and micro-foam), or by the liquid phase · I fy 'I shape is the surface tension and interface force The competition is classified as a wet foam (almost spherical bubbles - damp, or liquid volume fraction of more than 5%). The wet foam is shown on circle 3A.
未（多面體氣泡-液體的體積分率低於5% )顯示於第3B 圖。 濕泡沫具有最大的穩定性，因為當氣泡是多面體時， 如壬乾泡沫者，在表面張力與界面力之間有較大的競爭。 均勻的直徑也代表較大的穩定性，因為較小的氣泡會根據 拉普拉斯（Laplace)定律而流空至較大的氣泡内，因為對 於車又小的直徑，將會有較高的内部壓力。立即的硬化泡沫， 像是孟弗樂克斯氏（M〇nfreux)泡沫，通常具有兩階段的 運：狀態，在產生之後的非常早期扮演具有多面體氣泡的 c心沫，然後，當氣泡溶解產生較濕的環境時，泡沫具有 求开V的軋泡。更標準化的硬化泡;末（例如，特沙力氏 二eSSan)泡沫）即使在一開始的階段也似乎是濕的。這 二考的穩定性及均勾性。另-種將泡泳分類的方法 :、衣造的標準：對於立即的泡沫，它可 乎是非常穩J “準的泡珠’它是最大的。即使當它似 石 〜疋日守，泡沫總是在不同的泡沫之間發展。 :化泡沫顯示出獨特的性質：絲以 性、 (或可以小針注射的能力，而不合# 4 # & 性）、對於相 卜㈢長失其特 ,^ 问數置的旋邀作居敖之較大的體籍^ + 長靜脈部分的 叼體積（處理較 作用）4 犯）、燾##身嚴（長到足夠用於、二虎 、增強的痙攣產生、Μ的靜脈心 I每 队杲血液之 18 200808261 較少的風險）、回聲可見度、具有烕少藥物鋼量及濃复 的硬允鹿力之增逄及對於内皮作用的選擇性（如果發生夕^ 滲的較低風險）。這些泡沫的作用經發現結合敏化劑（替 莫泊吩）是優異的，泡沫對於内皮的作用具有長持續期間 的選擇性及黏著性，以及這個作用可幫助替莫泊吩穿透到 靜脈壁内，並且使其有更深層的作用。替莫泊吩的作用也 可幫助硬化泡沫。在活化之後，細胞的破壞使硬化泡沫在 短時間内完成痙攣產生，並且明確地關閉靜脈。替莫泊吩 溶液在硬化泡沫中的穩定性被預測是有限的，並且因此所 觀察到的優異活性對於熟悉於此技藝者而言是意想不到 的。 實施例1 : 這位64歲男性患者在過去每隻腿都以手術介入兩次， 並且被診斷為附屬於功能不全性穿孔靜脈的靜脈曲張。 第4_E/ ( 1A至1B )圈說明在處理之前，可觀察到在 膝蓋下方腿部外表的靜脈曲張形成。它們提供以最小的努 =就可看見的重要執跡。用於這個實施例的特定硬化泡洙 疋以聚十二醇1% (清潔劑溶液）加Ji 3G%葡萄糖溶液及 ^0 ng/ml的替莫泊吩所製備。 第4-E/ ( 1C至1D)圖說明光動力硬化泡沫的施用。 蝴蝶針用於導人光動力硬化泡珠。此外，要時，超音 波導引是用於植入灌輸導管定位。 第4_E/ ( 1E及1F)圖顯示雷射輻射（652 nm)的施 用，以供活化替莫泊吩：藥物的光間隔是15分鐘，以及 19 200808261 最終的光能量是約16焦耳/平方公分。這個劑量已被完全 而才受而沒有副作用，並且對於以這個PDF的良好處理是充 足的。 為了判斷替莫泊吩的活化是追縱在如照片所示的處理 區域中之溫度上升。在這些照片中，第4-E/ ( 1G及1H ) 圈’我們可觀察到在活化開始時的溫度34·5^，以及在活 化之後的溫度37°C。這個溫度隨著光動力硬化症活化上升 2 · 5 C是替莫泊吩活化的外部表現。 在接下來的照片中，第4-E/ ( II至1J)圖，在雷射 活化1 5分鐘之後，有持續的1°C溫度上升。 第心E/ (1K至1L)國顯示在PDS 7天之後處理區域 的進展：靜脈曲張已經消失，並且沒有纖維索。也沒有瘀 血、血腫以及色素沈著。 實施例2 : 在第5_E/ (1A及1B)圈中，一位7〇歲的老年婦女在 15天之前進行雷射内血管處理，但現在將pDs (光動力硬 化症）施加到膝蓋後方：所使用的光動力硬化症泡沫是聚 十一醇 1.25% 加上 Foslip 50 ng/ml。 第S-E/ ( 2C及2D)圈顯示雷射活化：在2〇焦耳/平 方公分的能量密度之。將靜脈移除以用於組織學研究。 雖然上述實施例與泡沫一起使用光敏化劑以形成丸 塊，以避免光動力硬化症組成物流經所關心的靜脈，但也 可不使用泡沫，但將阻斷工具施加到一個或多個靜脈，以 避免敏化劑本身流經靜脈，直到在提供處理之後為止。阻 20 200808261 藉由導管施加的氣球或先前萎 斷工具可以是外部的壓縮 縮的靜脈部分。 不僅在腿部會有靜脈曲張，而且在食道黏膜中也奋有 靜脈曲張，在食道黏膜中處理是困難的，並且在處理；間 會有出血的危險。過去已有藉由硬化症治療的處理，但pDs 應更為有效且更快速，兩個不可或缺的條件以得到優異的 雖然已參考附圖說明本發明的較佳具體實例，但應理 解的是’本發明並不限於刻板的具體實例，而且各種：改 變及修改都可由熟悉於此技藝者在此達成，而不脫離本發 明由附屬申請專利範圍所定義的範疇或精神。 【圖式簡單說明】 第1圖說明替莫泊吩與靜脈壁細胞交互作用的過程。 第2A至2C圖說明如何進行硬化症處理：以針將硬化 產物導入靜脈曲張中（A);之後產生纖維索（B);以及 在45天内纖維索消失（c)。 第3 A及3B圖說明不同的泡沫及氣泡形成。 士第4圖E/ ( 1A至1L)說明在下肢處理靜脈曲張的連 、續片，照片1A及1B說明靜脈的外觀；照片i c說明施 用光動力硬化症組成物以及之後的腿部；照片1E及lF古兒 明將雷射輻射施用至腿部；照片1G、1H、II及u說明在 施用雷射輻射之後處理區域的溫度上升；以及照片1k&il 說明在處理7天之後的相同區域，顯示在腿上靜脈的消失 以及沒有其他併發的藥物治療症狀。 21 200808261 第5圖E/ (2A i 2D)說明處理膝蓋後方靜脈曲張的 連績如、片，照片2A疋後膝盒區域的處理前照片；照片a 是顯示插入光動力硬化症組成物的照片；照片2C顯示施 用雷射輻射；以及照片2D說明處理之後的相同區域。 第6A至6B圖說明移除處理的靜脈以及靜脈本身，以 用於組織學研究。 【主要元件符號說明】 無 22No (polyhedral bubble-liquid volume fraction below 5%) is shown in Figure 3B. Wet foam has the greatest stability because when the bubble is a polyhedron, such as a dry foam, there is a greater competition between surface tension and interfacial force. Uniform diameter also represents greater stability, as smaller bubbles will flow out into larger bubbles according to Laplace's law, because for cars with smaller diameters, there will be higher Internal pressure. An immediate hardening foam, such as a M〇nfreux foam, usually has a two-stage operation: a state in which it plays a c-foam with polyhedral bubbles very early after production, and then, when the bubbles are dissolved In a relatively wet environment, the foam has a crater that opens to V. More standardized hardened vesicles; at the end (eg, Tessa II eSSan) foams appear to be wet even at the beginning. The stability and consistency of these two tests. Another way to classify the bubble: the standard of clothing: for the immediate foam, it can be very stable J "quasi-beads" it is the biggest. Even when it is like stone ~ 疋 守, foam Always develop between different bubbles. : Foam shows a unique nature: silky sex, (or the ability to inject a small needle, not #4 # & sex), for the relationship (three) long lost, ^ Ask the number of spins to invite the larger body of the residence ^ + the volume of the long vein part of the sputum volume (handling effect) 4 guilty), 焘 ## body strict (long enough for, two tigers, enhanced痉挛 痉挛 痉挛 静脉 静脉 静脉 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 The lower risk of osmotic osmosis. The effects of these foams have been found to be excellent in combination with sensitizers (tenpropophene), which have a long-lasting selectivity and adhesion to the action of the endothelium, and this effect can be Helps temotope penetrate into the vein wall and make it A deeper effect. The action of temopophene also helps to harden the foam. After activation, the destruction of the cells causes the hardened foam to complete the sputum production in a short time and clears the vein clearly. The temopophene solution is in the hardened foam. The stability is predicted to be limited, and thus the excellent activity observed is unexpected for those skilled in the art. Example 1: This 64-year-old male patient has surgically involved two in each leg in the past. Times, and was diagnosed as a varicose vein attached to a perforated perforated vein. The 4_E/(1A to 1B) circle indicates that varicose vein formation can be observed on the surface of the leg below the knee before treatment. They are provided with minimal Nuo = an important manifestation that can be seen. The specific sclerosing foam used in this example is polydodecanol 1% (detergent solution) plus Ji 3G% glucose solution and ^0 ng/ml of temopol The 4-E/(1C to 1D) diagram illustrates the application of a photodynamically sclerosing foam. The butterfly needle is used to introduce photodynamically sclerosing vesicles. In addition, when needed, ultrasonic guidance is used to implant the infusion catheter. Positioning Figure 4_E/(1E and 1F) shows the application of laser radiation (652 nm) for activation of temopophene: the light interval of the drug is 15 minutes, and 19 200808261 The final light energy is about 16 joules/square This dose has been completely accepted without side effects and is sufficient for good handling with this PDF. To determine the activation of temoprebe is to trace the temperature rise in the treated area as shown in the photograph. In these photographs, the 4-E/(1G and 1H) circle 'we can observe the temperature at the start of activation 34·5^, and the temperature after activation at 37 ° C. This temperature follows photodynamic sclerosis The increase in activation 2 · 5 C is an external manifestation of the activation of temopost. In the next photograph, the 4-E/(II to 1J) graph shows a continuous temperature rise of 1 °C after 15 minutes of laser activation. The first heart E/(1K to 1L) country showed progress in the treated area after 7 days of PDS: the varicose veins had disappeared and there was no fiber cord. There is also no blood stasis, hematoma, and pigmentation. Example 2: In the 5_E/(1A and 1B) circle, a 7-year-old elderly woman performed laser internal vascular treatment 15 days ago, but now pDs (photodynamic sclerosis) is applied to the back of the knee: The photodynamic sclerosis foam used was 1.25% polyundecyl alcohol plus Foslip 50 ng/ml. The S-E/ (2C and 2D) circle shows laser activation: energy density at 2 〇 joules per square centimeter. The vein was removed for histological studies. While the above examples use a photosensitizer with the foam to form a pellet to avoid the photodynamic sclerosis composition stream passing through the vein of interest, it is also possible to dispense the foam, but apply a blocking tool to one or more veins to The sensitizer itself is prevented from flowing through the vein until after the treatment is provided. Resistance 20 200808261 A balloon or a previously aborted tool applied by a catheter can be an external compressed constricted vein portion. Not only varicose veins in the legs, but also varicose veins in the esophageal mucosa, it is difficult to treat in the esophageal mucosa, and there is a risk of bleeding between them. There have been treatments for the treatment of sclerosis in the past, but pDs should be more effective and faster, and two indispensable conditions are preferred. Although preferred embodiments of the invention have been described with reference to the drawings, it should be understood It is to be understood that the invention is not limited to the specific embodiments of the invention, and various changes and modifications may be made by those skilled in the art without departing from the scope or spirit of the invention as defined by the appended claims. [Simple description of the diagram] Figure 1 illustrates the process of interaction between temopophen and venous wall cells. Figs. 2A to 2C illustrate how the sclerosis treatment is performed: the hardened product is introduced into the varicose vein by the needle (A); then the fiber cord (B) is produced; and the fiber cord disappears within 45 days (c). Figures 3A and 3B illustrate different foam and bubble formation. Figure 4 E/(1A to 1L) describes the treatment of venous varices in the lower extremities, photographs 1A and 1B illustrating the appearance of the vein; photograph ic indicating the application of the photodynamic sclerosis composition and subsequent legs; Photo 1E And lF Guering applied laser radiation to the legs; photographs 1G, 1H, II and u indicate the temperature rise of the treated area after application of the laser radiation; and the photograph 1k&il indicates the same area after 7 days of treatment, Shows the disappearance of veins on the legs and no other concurrent medication symptoms. 21 200808261 Fig. 5 E/(2A i 2D) illustrates the pre-treatment photographs of the knee hamper area in the posterior varicose veins of the knee, and the photo of the posterior knee box area in photograph 2A; photograph a is a photograph showing the composition of the photodynamic sclerosis Photo 2C shows the application of laser radiation; and Photo 2D illustrates the same area after processing. Figures 6A through 6B illustrate the removal of the treated vein as well as the vein itself for histological studies. [Main component symbol description] None 22