TW200745044A - Pyrazole derivatives, compositions containing such compounds and methods of use - Google Patents
Pyrazole derivatives, compositions containing such compounds and methods of useInfo
- Publication number
- TW200745044A TW200745044A TW095137554A TW95137554A TW200745044A TW 200745044 A TW200745044 A TW 200745044A TW 095137554 A TW095137554 A TW 095137554A TW 95137554 A TW95137554 A TW 95137554A TW 200745044 A TW200745044 A TW 200745044A
- Authority
- TW
- Taiwan
- Prior art keywords
- compounds
- methods
- compositions containing
- pyrazole derivatives
- pyrazoles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72817705P | 2005-10-19 | 2005-10-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW200745044A true TW200745044A (en) | 2007-12-16 |
Family
ID=37603075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW095137554A TW200745044A (en) | 2005-10-19 | 2006-10-12 | Pyrazole derivatives, compositions containing such compounds and methods of use |
Country Status (14)
Country | Link |
---|---|
US (1) | US20070088070A1 (zh) |
EP (1) | EP1940799A1 (zh) |
KR (1) | KR20080058416A (zh) |
CN (1) | CN101291912A (zh) |
AR (1) | AR056574A1 (zh) |
AU (1) | AU2006304485A1 (zh) |
CA (1) | CA2624532A1 (zh) |
DO (1) | DOP2006000231A (zh) |
IL (1) | IL190477A0 (zh) |
NO (1) | NO20082256L (zh) |
PE (1) | PE20070503A1 (zh) |
RU (1) | RU2008119496A (zh) |
TW (1) | TW200745044A (zh) |
WO (1) | WO2007047676A1 (zh) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE490244T1 (de) * | 2003-01-27 | 2010-12-15 | Merck Sharp & Dohme | Substituierte pyrazole, zusammensetzungen,die solche verbindungen enthalten, und anwendungsverfahren |
DE602005006806D1 (de) * | 2004-06-04 | 2008-06-26 | Merck & Co Inc | Pyrazolderivate, zusammensetzungen, die solche verbindungen enthalten, und anwendungsverfahren |
EP1773330B1 (en) | 2004-07-22 | 2010-05-26 | Merck Sharp & Dohme Corp. | Substituted pyrazoles, compositions containing such compounds and methods of use |
US7709658B2 (en) * | 2005-07-26 | 2010-05-04 | Merck Sharp & Dohme Corp. | Process for synthesizing a substituted pyrazole |
US8143284B2 (en) | 2006-10-05 | 2012-03-27 | Abbott Laboratories | Poly(ADP-ribose)polymerase inhibitors |
JP2011520897A (ja) | 2008-05-16 | 2011-07-21 | シェーリング コーポレイション | グルカゴン受容体アンタゴニスト、組成物およびそれらの使用方法 |
EP2440553B1 (en) * | 2009-06-12 | 2017-08-23 | Merck Sharp & Dohme Corp. | Thiophenes as glucagon receptor antagonists, compositions, and methods for their use |
SG191040A1 (en) | 2010-12-23 | 2013-08-30 | Pfizer | Glucagon receptor modulators |
PE20140253A1 (es) | 2011-02-08 | 2014-03-09 | Pfizer | Moduladores del receptor de glucagon |
EP2734503B1 (en) | 2011-07-22 | 2015-09-16 | Pfizer Inc. | Quinolinyl glucagon receptor modulators |
TW201427658A (zh) * | 2012-12-10 | 2014-07-16 | Merck Sharp & Dohme | 藉由投予升糖素受體拮抗劑及膽固醇吸收抑制劑治療糖尿病之方法 |
US9493439B1 (en) * | 2014-04-07 | 2016-11-15 | University Of Kentucky Research Foundation | Proteasome inhibitors |
EP3506940A1 (en) | 2016-08-30 | 2019-07-10 | Regeneron Pharmaceuticals, Inc. | Methods of treating severe insulin resistance by interfering with glucagon receptor signaling |
WO2018075792A1 (en) | 2016-10-20 | 2018-04-26 | Regeneron Pharmaceuticals, Inc. | Methods of lowering blood glucose levels |
CA3071387A1 (en) | 2017-08-22 | 2019-02-28 | Regeneron Pharmaceuticals, Inc. | Methods of treating urea cycle disorders by interfering with glucagon receptor signaling |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE490244T1 (de) * | 2003-01-27 | 2010-12-15 | Merck Sharp & Dohme | Substituierte pyrazole, zusammensetzungen,die solche verbindungen enthalten, und anwendungsverfahren |
DE602005006806D1 (de) * | 2004-06-04 | 2008-06-26 | Merck & Co Inc | Pyrazolderivate, zusammensetzungen, die solche verbindungen enthalten, und anwendungsverfahren |
-
2006
- 2006-10-09 AR ARP060104439A patent/AR056574A1/es not_active Application Discontinuation
- 2006-10-12 TW TW095137554A patent/TW200745044A/zh unknown
- 2006-10-16 AU AU2006304485A patent/AU2006304485A1/en not_active Abandoned
- 2006-10-16 CN CNA2006800389530A patent/CN101291912A/zh active Pending
- 2006-10-16 EP EP06817064A patent/EP1940799A1/en not_active Withdrawn
- 2006-10-16 WO PCT/US2006/040558 patent/WO2007047676A1/en active Application Filing
- 2006-10-16 PE PE2006001250A patent/PE20070503A1/es not_active Application Discontinuation
- 2006-10-16 RU RU2008119496/04A patent/RU2008119496A/ru unknown
- 2006-10-16 CA CA002624532A patent/CA2624532A1/en not_active Abandoned
- 2006-10-16 KR KR1020087009336A patent/KR20080058416A/ko not_active Application Discontinuation
- 2006-10-18 DO DO2006000231A patent/DOP2006000231A/es unknown
- 2006-10-19 US US11/583,253 patent/US20070088070A1/en not_active Abandoned
-
2008
- 2008-03-27 IL IL190477A patent/IL190477A0/en unknown
- 2008-05-16 NO NO20082256A patent/NO20082256L/no unknown
Also Published As
Publication number | Publication date |
---|---|
US20070088070A1 (en) | 2007-04-19 |
PE20070503A1 (es) | 2007-06-14 |
IL190477A0 (en) | 2008-11-03 |
CN101291912A (zh) | 2008-10-22 |
CA2624532A1 (en) | 2007-04-26 |
NO20082256L (no) | 2008-07-15 |
EP1940799A1 (en) | 2008-07-09 |
RU2008119496A (ru) | 2009-12-10 |
KR20080058416A (ko) | 2008-06-25 |
AR056574A1 (es) | 2007-10-10 |
WO2007047676A1 (en) | 2007-04-26 |
DOP2006000231A (es) | 2007-05-31 |
AU2006304485A1 (en) | 2007-04-26 |
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