TW200718678A - Methods of preparing MEK inhibitor - Google Patents
Methods of preparing MEK inhibitorInfo
- Publication number
- TW200718678A TW200718678A TW095121036A TW95121036A TW200718678A TW 200718678 A TW200718678 A TW 200718678A TW 095121036 A TW095121036 A TW 095121036A TW 95121036 A TW95121036 A TW 95121036A TW 200718678 A TW200718678 A TW 200718678A
- Authority
- TW
- Taiwan
- Prior art keywords
- methods
- mek inhibitor
- preparing
- preparing mek
- phenylamino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
This invention relates to methods of preparing MEK inhibitor N-[(R)-2,3-dihydroxy-propoxy]-3,4- difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide that useful for treating diseases mediated by MEK activity in mammals. The present invention provides new synthetic routes that are safe, efficient and cost effective when carried out on a commercial scale.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69062005P | 2005-06-14 | 2005-06-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW200718678A true TW200718678A (en) | 2007-05-16 |
Family
ID=36952557
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW095121036A TW200718678A (en) | 2005-06-14 | 2006-06-13 | Methods of preparing MEK inhibitor |
Country Status (4)
Country | Link |
---|---|
JP (1) | JP2006348034A (en) |
AR (1) | AR057362A1 (en) |
TW (1) | TW200718678A (en) |
WO (1) | WO2006134469A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20130113430A (en) * | 2010-08-05 | 2013-10-15 | 케이스 웨스턴 리저브 유니버시티 | Inhibitors of erk for developmental disorders of neuronal connectivity |
CN103204822B (en) | 2012-01-17 | 2014-12-03 | 上海科州药物研发有限公司 | Benzoxazole compounds as protein kinase inhibitors, and preparation method and application thereof |
WO2022177557A1 (en) | 2021-02-17 | 2022-08-25 | Springworks Therapeutics, Inc. | Crystalline solids of mek inhibitor n-((r)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide and uses thereof |
US11084780B1 (en) | 2021-02-17 | 2021-08-10 | Springworks Therapeutics, Inc. | Crystalline solids of MEK inhibitor N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide and uses thereof |
US11066358B1 (en) | 2021-02-17 | 2021-07-20 | Warner-Lambert Company Llc | Compositions of essentially pure form IV of N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide and uses thereof |
IL304974A (en) | 2021-02-17 | 2023-10-01 | Warner Lambert Co | Compositions of essentially pure form iv of n-((r)-2,3- dihydroxypropoxy)-3,4-difluoro-2- (2-fluoro-4-iodophenylamino)- benzamide and uses thereof |
US11571402B2 (en) | 2021-02-17 | 2023-02-07 | Springworks Therapeutics, Inc. | Dispersible formulations of N-((R)-2,3-dihydroxypropoly)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide and uses thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4965270A (en) * | 1987-05-30 | 1990-10-23 | Beecham Group P.L.C. | Purine derivatives |
AU2001273498B2 (en) * | 2000-07-19 | 2006-08-24 | Warner-Lambert Company | Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids |
EP1682495A1 (en) * | 2003-10-21 | 2006-07-26 | Warner-Lambert Company LLC | Polymorphic form of n- (r)-2,3-dihydroxy-propoxy -3,4-d ifluoro-2-(2-fluoro-4-iodophenylamino)-benzamide |
-
2006
- 2006-06-01 WO PCT/IB2006/001584 patent/WO2006134469A1/en active Application Filing
- 2006-06-12 AR ARP060102448A patent/AR057362A1/en unknown
- 2006-06-13 TW TW095121036A patent/TW200718678A/en unknown
- 2006-06-13 JP JP2006163689A patent/JP2006348034A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
AR057362A1 (en) | 2007-11-28 |
WO2006134469A1 (en) | 2006-12-21 |
JP2006348034A (en) | 2006-12-28 |
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