AR057362A1 - PROCEDURES TO PREPARE A MEK INHIBITOR - Google Patents

PROCEDURES TO PREPARE A MEK INHIBITOR

Info

Publication number
AR057362A1
AR057362A1 ARP060102448A ARP060102448A AR057362A1 AR 057362 A1 AR057362 A1 AR 057362A1 AR P060102448 A ARP060102448 A AR P060102448A AR P060102448 A ARP060102448 A AR P060102448A AR 057362 A1 AR057362 A1 AR 057362A1
Authority
AR
Argentina
Prior art keywords
procedures
mek inhibitor
prepare
mek
effective
Prior art date
Application number
ARP060102448A
Other languages
Spanish (es)
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of AR057362A1 publication Critical patent/AR057362A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La presente se refiere a procedimientos para preparar el inhibidor de MEK N-[( R)-2,3-dihidroxi-propoxi]-3,4-difluoro-2-(2fluoro-4-yodo-fenilamino)-benzamida que es util para tratar enfermedades mediadas por actividad MEK en mamíferos. La presente proporciona nuevas rutas sintéticas que son seguras, eficaces y rentables cuando se llevan a cabo a escala industrial.This refers to procedures for preparing the MEK inhibitor N - [(R) -2,3-dihydroxy-propoxy] -3,4-difluoro-2- (2fluoro-4-iodo-phenylamino) -benzamide which is useful to treat diseases mediated by MEK activity in mammals. This provides new synthetic routes that are safe, effective and cost effective when carried out on an industrial scale.

ARP060102448A 2005-06-14 2006-06-12 PROCEDURES TO PREPARE A MEK INHIBITOR AR057362A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69062005P 2005-06-14 2005-06-14

Publications (1)

Publication Number Publication Date
AR057362A1 true AR057362A1 (en) 2007-11-28

Family

ID=36952557

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060102448A AR057362A1 (en) 2005-06-14 2006-06-12 PROCEDURES TO PREPARE A MEK INHIBITOR

Country Status (4)

Country Link
JP (1) JP2006348034A (en)
AR (1) AR057362A1 (en)
TW (1) TW200718678A (en)
WO (1) WO2006134469A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130113430A (en) * 2010-08-05 2013-10-15 케이스 웨스턴 리저브 유니버시티 Inhibitors of erk for developmental disorders of neuronal connectivity
CN103204822B (en) 2012-01-17 2014-12-03 上海科州药物研发有限公司 Benzoxazole compounds as protein kinase inhibitors, and preparation method and application thereof
WO2022177557A1 (en) 2021-02-17 2022-08-25 Springworks Therapeutics, Inc. Crystalline solids of mek inhibitor n-((r)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide and uses thereof
US11084780B1 (en) 2021-02-17 2021-08-10 Springworks Therapeutics, Inc. Crystalline solids of MEK inhibitor N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide and uses thereof
US11066358B1 (en) 2021-02-17 2021-07-20 Warner-Lambert Company Llc Compositions of essentially pure form IV of N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide and uses thereof
IL304974A (en) 2021-02-17 2023-10-01 Warner Lambert Co Compositions of essentially pure form iv of n-((r)-2,3- dihydroxypropoxy)-3,4-difluoro-2- (2-fluoro-4-iodophenylamino)- benzamide and uses thereof
US11571402B2 (en) 2021-02-17 2023-02-07 Springworks Therapeutics, Inc. Dispersible formulations of N-((R)-2,3-dihydroxypropoly)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965270A (en) * 1987-05-30 1990-10-23 Beecham Group P.L.C. Purine derivatives
AU2001273498B2 (en) * 2000-07-19 2006-08-24 Warner-Lambert Company Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids
EP1682495A1 (en) * 2003-10-21 2006-07-26 Warner-Lambert Company LLC Polymorphic form of n- (r)-2,3-dihydroxy-propoxy -3,4-d ifluoro-2-(2-fluoro-4-iodophenylamino)-benzamide

Also Published As

Publication number Publication date
WO2006134469A1 (en) 2006-12-21
TW200718678A (en) 2007-05-16
JP2006348034A (en) 2006-12-28

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