TW200612915A - Five-membered heterocycles useful as serine protease inhibitors - Google Patents
Five-membered heterocycles useful as serine protease inhibitorsInfo
- Publication number
- TW200612915A TW200612915A TW094119563A TW94119563A TW200612915A TW 200612915 A TW200612915 A TW 200612915A TW 094119563 A TW094119563 A TW 094119563A TW 94119563 A TW94119563 A TW 94119563A TW 200612915 A TW200612915 A TW 200612915A
- Authority
- TW
- Taiwan
- Prior art keywords
- formula
- compounds
- factor
- serine protease
- protease inhibitors
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The present invention provides a method for treating a thrombotic or an inflammatory disorder administering to a patient in need thereof a therapeutically effective amount of at least one compound of Formula (I) or Formula (V): or a stereoisomer or pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z,R3, R4, R6, R11, X1, X2, and X3 are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also provides compounds within the scope of Formula I and relates to pharmaceutical compositions comprising these compounds.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57963804P | 2004-06-15 | 2004-06-15 | |
| US68412705P | 2005-05-24 | 2005-05-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200612915A true TW200612915A (en) | 2006-05-01 |
Family
ID=36940556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094119563A TW200612915A (en) | 2004-06-15 | 2005-06-14 | Five-membered heterocycles useful as serine protease inhibitors |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR049645A1 (en) |
| PE (1) | PE20060300A1 (en) |
| TW (1) | TW200612915A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021535093A (en) * | 2018-08-13 | 2021-12-16 | ウェスタン ユニバーシティ オブ ヘルス サイエンシズ | Calpain-2 Selective Inhibitor Compounds for the Treatment of Glaucoma |
-
2005
- 2005-06-14 PE PE2005000681A patent/PE20060300A1/en not_active Application Discontinuation
- 2005-06-14 TW TW094119563A patent/TW200612915A/en unknown
- 2005-06-14 AR ARP050102438A patent/AR049645A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR049645A1 (en) | 2006-08-23 |
| PE20060300A1 (en) | 2006-04-20 |
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