MXPA06014799A - Six-membered heterocycles useful as serine protease inhibitors. - Google Patents

Six-membered heterocycles useful as serine protease inhibitors.

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Publication number
MXPA06014799A
MXPA06014799A MXPA06014799A MXPA06014799A MXPA06014799A MX PA06014799 A MXPA06014799 A MX PA06014799A MX PA06014799 A MXPA06014799 A MX PA06014799A MX PA06014799 A MXPA06014799 A MX PA06014799A MX PA06014799 A MXPA06014799 A MX PA06014799A
Authority
MX
Mexico
Prior art keywords
factor
compounds
serine protease
protease inhibitors
membered heterocycles
Prior art date
Application number
MXPA06014799A
Other languages
Spanish (es)
Inventor
Mimi Quan
Joanne M Smallheer
James Corte
Jon Hangeland
Tianan Fang
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35276485&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MXPA06014799(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MXPA06014799A publication Critical patent/MXPA06014799A/en

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/63—One oxygen atom
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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Abstract

The present invention provides compounds of Formula (I) or a stereoisomer or pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, X1, X2, X3, X4, and X5 are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
MXPA06014799A 2004-06-15 2005-06-14 Six-membered heterocycles useful as serine protease inhibitors. MXPA06014799A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US57963704P 2004-06-15 2004-06-15
US68383805P 2005-05-24 2005-05-24
US11/151,627 US7429604B2 (en) 2004-06-15 2005-06-13 Six-membered heterocycles useful as serine protease inhibitors
PCT/US2005/020971 WO2005123680A1 (en) 2004-06-15 2005-06-14 Six-membered heterocycles useful as serine protease inhibitors

Publications (1)

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MXPA06014799A true MXPA06014799A (en) 2007-02-16

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Country Link
US (1) US7429604B2 (en)
EP (1) EP1773775B1 (en)
JP (1) JP4834663B2 (en)
CN (1) CN101010299B (en)
AT (1) ATE520662T1 (en)
AU (1) AU2005255029A1 (en)
MX (1) MXPA06014799A (en)
NO (1) NO20070201L (en)
WO (1) WO2005123680A1 (en)

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