TW200609229A - The polymorphic form of sodium mycophenolate and its producing method - Google Patents

The polymorphic form of sodium mycophenolate and its producing method

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Publication number
TW200609229A
TW200609229A TW093127745A TW93127745A TW200609229A TW 200609229 A TW200609229 A TW 200609229A TW 093127745 A TW093127745 A TW 093127745A TW 93127745 A TW93127745 A TW 93127745A TW 200609229 A TW200609229 A TW 200609229A
Authority
TW
Taiwan
Prior art keywords
polymorphic form
type
sodium mycophenolate
producing method
mixture
Prior art date
Application number
TW093127745A
Other languages
Chinese (zh)
Inventor
guang-zong Li
Bing-Shu Chen
Original Assignee
Chunghwa Chemical Synthesis & Biotech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chunghwa Chemical Synthesis & Biotech Co Ltd filed Critical Chunghwa Chemical Synthesis & Biotech Co Ltd
Priority to TW093127745A priority Critical patent/TW200609229A/en
Publication of TW200609229A publication Critical patent/TW200609229A/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

This invention relates to an I type and an II type polymorphic form of sodium mycophenolate and their producing method. In this invention, sodium mycophenolate is reacted with alkali to obtain the mixture of the I type and the II type polymorphic form of sodium mycophenolate. The mixture is heated and circulated in organic solution like alcohol, ester, or ketone for 0.5 to10 hours to obtain the I type polymorphic form. The I type polymorphic form or the mixture of the I type and the II type polymorphic form of sodium mycophenolate is put in an airtight container with a relative humidity of 75 to 96% for about 3 to 28 days to obtain the II type polymorphic form.
TW093127745A 2004-09-14 2004-09-14 The polymorphic form of sodium mycophenolate and its producing method TW200609229A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
TW093127745A TW200609229A (en) 2004-09-14 2004-09-14 The polymorphic form of sodium mycophenolate and its producing method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TW093127745A TW200609229A (en) 2004-09-14 2004-09-14 The polymorphic form of sodium mycophenolate and its producing method

Publications (1)

Publication Number Publication Date
TW200609229A true TW200609229A (en) 2006-03-16

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ID=57807484

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093127745A TW200609229A (en) 2004-09-14 2004-09-14 The polymorphic form of sodium mycophenolate and its producing method

Country Status (1)

Country Link
TW (1) TW200609229A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110922371A (en) * 2019-12-27 2020-03-27 广东蓝宝制药有限公司 Preparation method of M2 crystal form meclofenol sodium

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110922371A (en) * 2019-12-27 2020-03-27 广东蓝宝制药有限公司 Preparation method of M2 crystal form meclofenol sodium

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