TW200602070A - Composition comprising xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof - Google Patents

Composition comprising xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof

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Publication number
TW200602070A
TW200602070A TW093140030A TW93140030A TW200602070A TW 200602070 A TW200602070 A TW 200602070A TW 093140030 A TW093140030 A TW 093140030A TW 93140030 A TW93140030 A TW 93140030A TW 200602070 A TW200602070 A TW 200602070A
Authority
TW
Taiwan
Prior art keywords
same
disease
methods
cerebral
xanthoceras sorbifolia
Prior art date
Application number
TW093140030A
Other languages
Chinese (zh)
Other versions
TWI454269B (en
Inventor
Pui-Kwong Chan
May-Sung Mak
Yun Wang
Original Assignee
Pacific Arrow Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2004/033359 external-priority patent/WO2005037200A2/en
Application filed by Pacific Arrow Ltd filed Critical Pacific Arrow Ltd
Publication of TW200602070A publication Critical patent/TW200602070A/en
Application granted granted Critical
Publication of TWI454269B publication Critical patent/TWI454269B/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7012—Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)

Abstract

This invention provides novel compositions, methods and processes for producing extracts from Xanthoceras sorbifolia. The extract comprises alkaloids, coumarins, saccharides, proteins, polysaccharides, glycosides, saponins, tannins, acid, flavonoids and others. Uses of the compositions of the present invention include but is not limited to anti-cancer therapy; preventing cerebral aging; improving memory, cerebral functions; curing enuresis, frequent micturition, urinary incontinence, dementia, weak intelligence, Aizheimer's disease, autism, brain trauma, Parkinson's disease or other diseases caused by cerebral dysfunctions; treating arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, dizziness, kidney disorder, impotence or premature ejaculation. This invention provides compounds comprising at least one sugar, triterpene, such as Sapogenin, and at least one side chain at Carbon 21 and/or 22, such as Angeloyl groups. The compounds of the present have various pharmaceutical and therapeutic applications.
TW093140030A 2003-12-23 2004-12-22 Compounds isolated from xanthoceras sorbifolia, methods for preparing same and uses thereof TWI454269B (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US53210103P 2003-12-23 2003-12-23
US60785804P 2004-09-07 2004-09-07
US61381104P 2004-09-27 2004-09-27
US61737904P 2004-10-08 2004-10-08
PCT/US2004/033359 WO2005037200A2 (en) 2003-10-09 2004-10-08 Composition comprising xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof

Publications (2)

Publication Number Publication Date
TW200602070A true TW200602070A (en) 2006-01-16
TWI454269B TWI454269B (en) 2014-10-01

Family

ID=38498686

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093140030A TWI454269B (en) 2003-12-23 2004-12-22 Compounds isolated from xanthoceras sorbifolia, methods for preparing same and uses thereof

Country Status (5)

Country Link
EP (1) EP1708724A4 (en)
JP (1) JP4880479B2 (en)
CN (1) CN1972702B (en)
TW (1) TWI454269B (en)
WO (1) WO2005063273A1 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7727561B2 (en) 2001-08-31 2010-06-01 Pacific Arrow Limited Composition comprising Xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof
US8586719B2 (en) 2005-04-27 2013-11-19 Pacific Arrow Limited Triterpenes for modulating gene expression and cell membrane, and as antiprotozoal agents
US8614197B2 (en) 2003-10-09 2013-12-24 Pacific Arrow Limited Anti-tumor compounds with angeloyl groups
US8735558B2 (en) 2005-02-14 2014-05-27 Pacific Arrow Limited Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof
US8785405B2 (en) 2010-07-16 2014-07-22 Pacific Arrow Limited Compounds for treating cancer and other diseases
CN116555328A (en) * 2023-05-12 2023-08-08 东北林业大学 Application of xanthoceras sorbifolia XsMYB113-1 gene in establishment of plant genetic transformation system

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7514412B2 (en) 2003-10-09 2009-04-07 Pacific Arrow Limited Anticancer biangeloyl saponins
US7488753B2 (en) 2003-10-09 2009-02-10 Pacific Arrow Limited Composition comprising triterpene saponins and compounds with angeloyl functional group, methods for preparing same and uses thereof
US7262285B2 (en) 2003-10-09 2007-08-28 Pacific Arrow Limited Anticancer biangeloyl saponins
US9382285B2 (en) 2004-09-07 2016-07-05 Pacific Arrow Limited Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells
US10213451B2 (en) * 2004-09-07 2019-02-26 Pacific Arrow Limited Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells
CN100482254C (en) * 2006-01-12 2009-04-29 哈尔滨三乐生物工程有限公司 Method for extracting effective site of Xanthoceras sorbifolia hulled seed
CN101553497B (en) * 2006-09-01 2013-03-27 太平洋艾瑞有限公司 Anti-tumor compounds for inhibiting cancer growth
AU2008244648A1 (en) * 2007-02-16 2008-11-06 Pacific Arrow Limited Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof
CN101575619B (en) * 2009-06-18 2011-09-14 大连理工大学 Method for coproducing multiple products by taking shinyleaf yellowhorn as raw material
US9499577B2 (en) 2009-07-16 2016-11-22 Pacific Arrow Limited Natural and synthetic compounds for treating cancer and other diseases
CN101891792B (en) * 2010-06-29 2014-04-16 河南科技大学 Triterpene compounds in salvia miltiorrhiza flower and extraction method and application thereof
CN115197293A (en) * 2010-07-16 2022-10-18 太平洋艾瑞有限公司 Novel compounds useful for the treatment of cancer and other diseases
CN102362916B (en) * 2011-09-30 2013-02-20 张宁 Traditional Chinese medicinal compound extract product for protecting liver and preparation method thereof
CN103509077B (en) * 2012-06-15 2015-08-05 沈阳药科大学 Triterpene saponin componds and its production and use
CN104188979B (en) * 2014-08-11 2017-01-11 泰州祥泰康华医药科技有限公司 Application of Cleistanone O-(morpholinyl)ethyl derivative in preparation of drugs for treating ischemic brain injury
CN104432388B (en) * 2014-12-29 2017-07-04 陕西天宝大豆食品技术研究所 Shiny-leaved yellowhorn peptide nutrient food and preparation method thereof
CN106668275A (en) * 2015-11-05 2017-05-17 甘肃长瑞文冠果产业发展有限公司 Face beautification and bath therapy bag containing shinyleaf yellowhorn as active component
CN105418723B (en) * 2015-12-03 2018-10-12 苏州大学 A kind of tea saponin extract and preparation method thereof
RU2654709C1 (en) * 2017-04-26 2018-05-22 Федеральное государственное бюджетное образовательное учреждение высшего образования "Смоленский государственный медицинский университет" министерства здравоохранения Российской Федерации Anti-inflammatory agent
CN107875162A (en) * 2017-11-10 2018-04-06 沈阳药科大学 The preparation and application of oleanane-type triterpene saponin
CN109142610B (en) * 2018-11-13 2021-02-23 吕梁学院 Method for extracting, detecting and measuring content of triterpenoids in shiny-leaved yellowhorn
CN113072608B (en) * 2020-01-03 2022-06-07 沈阳药科大学 Triterpenoid saponin compound and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6616943B2 (en) * 2001-08-31 2003-09-09 Fountain Silver Limited Composition comprising Wenguanguo extracts and methods for preparing same
CN1350001A (en) * 2001-10-31 2002-05-22 杨柏珍 Can be used for extracting xanthoceras sorbifolia Bunge total saponin, crude fat, crude protein, and sugar
CN101242850B (en) * 2003-10-09 2013-03-20 太平洋艾瑞有限公司 Composition, function and use of xanthoceras sorbifolia extract and compound isolated from same, method for preparing same

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7727561B2 (en) 2001-08-31 2010-06-01 Pacific Arrow Limited Composition comprising Xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof
US8614197B2 (en) 2003-10-09 2013-12-24 Pacific Arrow Limited Anti-tumor compounds with angeloyl groups
US8735558B2 (en) 2005-02-14 2014-05-27 Pacific Arrow Limited Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof
US8586719B2 (en) 2005-04-27 2013-11-19 Pacific Arrow Limited Triterpenes for modulating gene expression and cell membrane, and as antiprotozoal agents
US8785405B2 (en) 2010-07-16 2014-07-22 Pacific Arrow Limited Compounds for treating cancer and other diseases
CN116555328A (en) * 2023-05-12 2023-08-08 东北林业大学 Application of xanthoceras sorbifolia XsMYB113-1 gene in establishment of plant genetic transformation system

Also Published As

Publication number Publication date
TWI454269B (en) 2014-10-01
JP4880479B2 (en) 2012-02-22
CN1972702B (en) 2013-01-23
CN1972702A (en) 2007-05-30
EP1708724A4 (en) 2009-11-11
EP1708724A1 (en) 2006-10-11
JP2007523058A (en) 2007-08-16
WO2005063273A1 (en) 2005-07-14

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