TW200505829A - Protease inhibitors for coronaviruses and sars-cov and the use thereof - Google Patents
Protease inhibitors for coronaviruses and sars-cov and the use thereofInfo
- Publication number
- TW200505829A TW200505829A TW093113953A TW93113953A TW200505829A TW 200505829 A TW200505829 A TW 200505829A TW 093113953 A TW093113953 A TW 093113953A TW 93113953 A TW93113953 A TW 93113953A TW 200505829 A TW200505829 A TW 200505829A
- Authority
- TW
- Taiwan
- Prior art keywords
- coronaviruses
- cov
- sars
- protease inhibitors
- picornaviruses
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C07K5/06095—Arg-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46809803P | 2003-05-06 | 2003-05-06 | |
| US47088103P | 2003-05-16 | 2003-05-16 | |
| US51284503P | 2003-10-21 | 2003-10-21 | |
| US53670104P | 2004-01-16 | 2004-01-16 | |
| US55136204P | 2004-03-10 | 2004-03-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200505829A true TW200505829A (en) | 2005-02-16 |
Family
ID=33459320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW093113953A TW200505829A (en) | 2003-05-06 | 2004-05-17 | Protease inhibitors for coronaviruses and sars-cov and the use thereof |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7504382B2 (zh) |
| EP (1) | EP1628674A2 (zh) |
| CA (1) | CA2524882A1 (zh) |
| TW (1) | TW200505829A (zh) |
| WO (1) | WO2004101742A2 (zh) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005011649A2 (en) * | 2003-05-19 | 2005-02-10 | Vanderbilt University | Methods of treating severe acute respiratory syndrome virus infections |
| WO2006061714A2 (en) * | 2004-12-09 | 2006-06-15 | Pfizer Inc. | Anticoronaviral compounds and compositions, their pharmaceutical uses and materials for their synthesis |
| US20100143890A1 (en) * | 2008-12-08 | 2010-06-10 | Electronics And Telecommunications Research Institute | Peptide compounds for capturing or inhibiting avian influenza virus and application thereof |
| JP5775519B2 (ja) | 2009-09-25 | 2015-09-09 | ニヴァリス・セラピューティクス・インコーポレーテッド | Ｓ−ニトロソグルタチオンレダクターゼ阻害薬としての新規ジヒドロピリミジン−２（１ｈ）−オン化合物 |
| ES2550939T3 (es) | 2010-07-16 | 2015-11-13 | Nivalis Therapeutics, Inc. | Nuevos compuestos de dihidropiridin-2-(1H)-ona como inhibidores de la S-nitrosoglutatión reductasa y antagonistas del receptor de la neurocinina-3 |
| WO2012039718A1 (en) | 2010-09-24 | 2012-03-29 | N30 Pharmaceuticals, Llc | Novel dihydropyrimidin-2(1h)-one compounds as neurokinin-3 receptor antagonists |
| CN115645393A (zh) * | 2020-02-26 | 2023-01-31 | 上海科技大学 | 二氢杨梅素在抗冠状病毒中的应用 |
| US11124497B1 (en) | 2020-04-17 | 2021-09-21 | Pardes Biosciences, Inc. | Inhibitors of cysteine proteases and methods of use thereof |
| WO2022072504A1 (en) * | 2020-09-29 | 2022-04-07 | Healion Bio, Inc. | Methods and compositions for the treatment of viral diseases |
| US11174231B1 (en) | 2020-06-09 | 2021-11-16 | Pardes Biosciences, Inc. | Inhibitors of cysteine proteases and methods of use thereof |
| US20220033383A1 (en) | 2020-07-20 | 2022-02-03 | Enanta Pharmaceuticals, Inc. | Functionalized peptides as antiviral agents |
| US20230340018A1 (en) * | 2020-08-18 | 2023-10-26 | Anixa Biosciences, Inc. | Mpro cysteine protease inhibitors |
| MX2023005983A (es) | 2020-11-23 | 2023-08-15 | Enanta Pharm Inc | Nuevos agentes antivirales derivados de la espiropirrolidina. |
| US11384090B2 (en) | 2020-11-23 | 2022-07-12 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| CN114524821A (zh) | 2020-11-23 | 2022-05-24 | 英安塔制药有限公司 | 新型螺旋吡咯烷衍生的抗病毒药物 |
| US11352363B1 (en) | 2020-11-23 | 2022-06-07 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| WO2022235605A1 (en) | 2021-05-04 | 2022-11-10 | Enanta Pharmaceuticals, Inc. | Novel macrocyclic antiviral agents |
| US11319325B1 (en) | 2021-05-11 | 2022-05-03 | Enanta Pharmaceuticals, Inc. | Macrocyclic spiropyrrolidine derived antiviral agents |
| US11339170B1 (en) | 2021-07-23 | 2022-05-24 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| US11325916B1 (en) | 2021-07-29 | 2022-05-10 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| WO2023086352A1 (en) | 2021-11-12 | 2023-05-19 | Enanta Pharmaceuticals, Inc. | Novel spiropyrrolidine derived antiviral agents |
| WO2023086400A1 (en) | 2021-11-12 | 2023-05-19 | Enanta Pharmaceuticals, Inc. | Novel spiropyrrolidine derived antiviral agents |
| WO2023086350A1 (en) | 2021-11-12 | 2023-05-19 | Enanta Pharmaceuticals, Inc. | Alkyne-containing antiviral agents |
| US11993600B2 (en) | 2021-12-08 | 2024-05-28 | Enanta Pharmaceuticals, Inc. | Saturated spirocyclics as antiviral agents |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4665070A (en) * | 1985-06-25 | 1987-05-12 | Syntex (U.S.A.) Inc. | 2-oxy-4H-3,1-benzoxazin-4-ones and pharmaceutical use |
| JPH05117169A (ja) * | 1991-10-29 | 1993-05-14 | Mitsubishi Kasei Corp | クロロメチルケトンの製法 |
| US6315995B1 (en) * | 1996-09-27 | 2001-11-13 | The Trustees Of Columbia University In The City Of New York | Methods for treating an ischemic disorder and improving stroke outcome |
| US6184210B1 (en) * | 1997-10-10 | 2001-02-06 | Cytovia, Inc. | Dipeptide apoptosis inhibitors and the use thereof |
| CA2323439A1 (en) * | 1998-03-16 | 1999-09-23 | Cytovia, Inc. | Dipeptide caspase inhibitors and the use thereof |
| US6248904B1 (en) * | 1998-07-21 | 2001-06-19 | Cytovia, Inc. | Fluorescence dyes and their applications for whole-cell fluorescence screening assays for caspases, peptidases, proteases and other enzymes and the use thereof |
| CN1346344A (zh) * | 1999-03-16 | 2002-04-24 | 西托维亚公司 | 取代的2－氨基苯甲酰胺天冬氨酸特异性半胱氨酸蛋白酶抑制剂及其应用 |
| JP2002541237A (ja) * | 1999-04-09 | 2002-12-03 | サイトビア インコーポレイテッド | カスパーゼインヒビターおよびその使用 |
| BR0012970A (pt) * | 1999-08-04 | 2002-04-30 | Agouron Pharma | Compostos e composições antipicornavirais, seus usos farmacêuticos e materiais para a sua sìntese |
| AU6894800A (en) * | 1999-08-06 | 2001-03-05 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| US6495522B1 (en) * | 1999-08-27 | 2002-12-17 | Cytovia, Inc. | Substituted alpha-hydroxy acid caspase inhibitors and the use thereof |
| US6566338B1 (en) * | 1999-10-12 | 2003-05-20 | Cytovia, Inc. | Caspase inhibitors for the treatment and prevention of chemotherapy and radiation therapy induced cell death |
| WO2002089745A2 (en) * | 2001-05-10 | 2002-11-14 | Cytovia, Inc. | Substituted n'-(arylcarbonyl)-benzhydrazides, n'-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| EP1399159A4 (en) * | 2001-06-01 | 2007-02-14 | Cytovia Inc | 4-SUBSTITUTE-1- (ARYLMETHYLIDENE) THIOSEMICARBAZIDE, 4-SUBSTITUTE-1- (ARYLCARBONYL) THIOSEMICARBAZIDE AND ANALOGUES AS ACTIVATORS OF APOPTOSIS CAPSASES AND TRIGS, AND USE THEREOF |
-
2004
- 2004-05-06 US US10/839,753 patent/US7504382B2/en not_active Expired - Fee Related
- 2004-05-06 CA CA002524882A patent/CA2524882A1/en not_active Abandoned
- 2004-05-06 EP EP04760886A patent/EP1628674A2/en not_active Withdrawn
- 2004-05-06 WO PCT/US2004/014068 patent/WO2004101742A2/en active Application Filing
- 2004-05-17 TW TW093113953A patent/TW200505829A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US7504382B2 (en) | 2009-03-17 |
| CA2524882A1 (en) | 2004-11-25 |
| US20080300191A1 (en) | 2008-12-04 |
| EP1628674A2 (en) | 2006-03-01 |
| WO2004101742A2 (en) | 2004-11-25 |
| WO2004101742A3 (en) | 2005-06-16 |
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