200403 A6 B6 經濟部中央標準局印製 五、發明説明（i ) 本發明係有關一種在膠囊中充瑱基本為粉狀藥物的設 備，該膠囊用於植入皮下，其中藥物透過囊壁擴散到血液 循璟中。預期使用目的可為諸如避孕激素以及安塔布司劑 等的投配。 在膠囊生産中，其起點是用以形成麟囊殼體的管料， 用以製造管料的適當材料為硅酮塑料。製造檄素膠囊的管 料•其直徑為1 * 5 mm。輸送到膠囊生産綫的管料以綿長 的管料方式從適當的設備中送出。在膠囊生産綫的起點， 將管料切成適當長度的膠囊坯料，其長度例如約為34m®。 然後將該膠囊坯料排成數個一行的行列。例如一行可 有12個坯料。將一個這種行列連在一起較為有利，以便形 成各後續工序的處理單元。為連接該處理犟元行列，可以 使用一個裝置，以保持該坯料在其預定位置上。借肋該裝 置可將該處理單元行列從一碱工序轉移到另一工序，也可 在每一工序中將其定位。所述裝置以具夾爪結構的夾盒較 為有利。該夾爪以共同彈簧加載作夾緊接觸，在夾爪的接 觸表面上形成共同互相配合的凹槽，以便形成容納膠囊坯 料的通孔。 在各後績的工序中，將材料的投配量從每一投配裝置 投放到在盤表面上製成的、起著振動運送器作用的相應的 輸送槽中〇投配的材料量在振動蓮送器中繼續前進，進入 裝料漏斗中，待充镇的膠囊坯料早已由夾爪夾盒載送而轉 移到該裝料漏斗之下方。為加速材料流入膠囊坯料中，採 用一種特別的螺旋進料器。所述進料器有一個直徑小於膠 {請先聞讀背面之注意事項再填"本页) 肀 4(210X297 公嬗) 200403 A6 B6 五、發明説明（2 ) 囊坯料的内徑的螺旋彈簧，其中有一條直的金鼷引導綫。 彈簧按其螺旋向前推進的方向旋轉。 就送料過程本身而言，在該工序進行過程中，螺旋彈 簧先插入膠囊坯料内，然後使之旋轉。在開始作旋轉動作 的同時，也開始從膠囊坯料中提高該螺旋彈簧。當旋轉方 向如上文所述時，該螺旋彈簧起著螺旋送料器的作用。在 進行膠囊坯料充填過程中，將螺旋彈簧邊旋轉邊從膠囊料 还中油出。在所述各操作階段中，繼纊保持裝料漏斗不停 振動。當螺旋彈簧頭升到所述要求的材料充填高度時，上 升動作停止，但彈簧的振動及旋轉動作繼續進行。於是螺 旋彈簧便決定充镇入綴囊的材料柱的高度。 充«階段之後，應將_囊坯料開口端的内表面清理， 清除拈附的充填材料，以保證还料端的封閉不出問題。可 用旋轉鏟刮心軸或相應的帚刷在膠囊料坯口的内部進行清 理工作。膠囊坯料端採用與上述關於膠囊坯料第一端封閉 相似的步驟進行封閉 <，密封過程中所用的膠劑硬化後，同 樣地可以將其密封部分的一部分切除以便精整膠囊的端部 Ο 經過這些工序階段後，將製成的穋囊輪送通過本身為 己知的工序，從而將膠囊清洗、乾燥、檢查、包裝及消毒 {請先聞碛背面之注意本項再填寫本頁) •^· •線. 經濟部中央標準局印裝 _τ, 其 > *» 0 述圖節 Μ影細 行投大 進向放 明三的 〇發的中 品本備域 製對設區 的圖填斗 用附充漏 備照及料 成參配進 製將投出 至中為示 直文一二 等下圖圖 甲 4(210Χ297公寿） 200403 A6 B6 經濟部中央標準局印敗 五、發明説明（） 3 將批量投配到槽盤2 1上的材料υ輪送到成橫行放置 在槽盤2 1後緣下方的裝料漏斗2 3中。在這些裝料漏斗 的下方，有一行由夾爪夾盒6載送的膠囊坯料7 ,該膠囊 坯的下端已封閉且以該下端已作精整為有利。 充镇器2 4包括進料器，其數目與裝料漏斗2 3的數 目相同。每一進料器有一個旋轉電機2 5、一根轉軸2 6 和安裝在該轉軸下端上的螺旋送料器。為使該螺旋送料器 能在待充填的膠囊那種小尺寸所決定的條件下工作，該裝 料螺旋由細螺旋彈簧製成。為便於控制螺旋彈簧的動作， 在彈簧内放置著另一條直的引導金屬綫，該金屬綫基本沿 螺旋彈簧的全部長度b伸展。 由螺旋彈簧製成的進料螺旋2 7被導引穿過裝料漏斗 2 3而達到其下面的膠囊坯料，并使之旋轉〇旋轉動作必 然選擇螺旋彈簧的送料方向。進料螺旋在膠囊坯料中旋轉 ,將供入裝料漏斗中的材料有效地送入醪囊坯料中。為防 止材料在膠囊料坯中發生不必要的壓賁，在進行充填的過 程中提高送料螺旋。在投配批量完全輸送後，進料螺旋也 已完全從_囊坯料中提出，然後轉移坯料，以將之封閉。 在封閉前可以將開口區的内部清理以便清除保留的任何充 请材料。用膠劑進行密封，·其方法與充慎前密封坯料S 一 端相同。 密封後，可通過剪切精整己充镇好的_囊端。精整後 ，將製成的膠囊從其柑應的夾爪夾盒中取出，然後按七而 簡單討論過的先有技術進行値別加工υ .................................................裝..............................打..........................線 (請先聞讀背面之注意事項再填寫本頁) 甲 4(210X297公沒） 200403 A6 B6 五、發明説明（，） 4 在圖一中有部份構件，因與本發明申請專利範圍無關 故未作進一步Μ述，其相關說明請參照第81 103143號專 利申請案。 {請先閲讀背面之注意事項再填寫本頁) •線· 經濟部中央標準局印裝 甲 4(210X 297公沒）200403 A6 B6 Printed by the Central Bureau of Standards of the Ministry of Economic Affairs 5. Description of the invention (i) The present invention relates to a device for filling a powdered medicine in a capsule, which is used for implantation under the skin, in which the medicine diffuses through the capsule wall to The blood is in circulation. The intended use can be for dosages such as contraceptive hormones and antabox. In the production of capsules, the starting point is the tube material used to form the capsule shell, and the suitable material for manufacturing the tube material is silicone plastic. Tubes for making prime capsules • The diameter is 1 * 5 mm. The tube material transported to the capsule production line is sent out from the appropriate equipment in the form of a long tube material. At the beginning of the capsule production line, the tube material is cut into capsule blanks of suitable length, for example with a length of approximately 34m®. The capsule blanks are then arranged in several rows. For example, there can be 12 blanks in a row. It is advantageous to connect one such row and column together to form a processing unit for each subsequent process. To connect the rows of processing elements, a device can be used to keep the blank in its predetermined position. The device can be used to transfer the processing unit ranks from one alkali process to another process, or it can be positioned in each process. The device is more advantageous with a clamping box with a clamping jaw structure. The clamping jaws are clamped in contact with a common spring, forming mutually cooperating grooves on the contact surfaces of the clamping jaws, so as to form a through hole for accommodating the capsule blank. In each subsequent process, the amount of material dispensed is dispensed from each dosing device into the corresponding conveying trough made on the surface of the disc and acting as a vibrating conveyor. The amount of material dispensed is vibrating The lotus feeder continues to advance into the charging hopper, and the capsule blank to be filled has already been carried by the clamping jaws and transferred to the bottom of the charging hopper. To accelerate the flow of material into the capsule blank, a special screw feeder is used. The feeder has a diameter less than the glue (please read the precautions on the back side and fill in this page first) 肀 4 (210X297 public transliteration) 200403 A6 B6 Fifth, the invention description (2) The inner diameter of the bladder blank spiral Spring, which has a straight guide wire. The spring rotates in the direction in which its spiral advances. As far as the feeding process itself is concerned, during this process, the spiral spring is inserted into the capsule blank and then rotated. Simultaneously with the start of the rotating action, the coil spring is also raised from the capsule blank. When the direction of rotation is as described above, the coil spring acts as a screw feeder. In the process of filling the capsule blank, the coil spring is rotated to release oil from the capsule. In each of the aforementioned operation phases, the charging funnel keeps vibrating continuously. When the coil spring head is raised to the required material filling height, the lifting action is stopped, but the vibration and rotation of the spring continue. The spiral spring then determines the height of the column of material that fills the bladder. After the filling stage, the inner surface of the open end of the bladder blank should be cleaned, and the enclosed filling material should be removed to ensure that the closing of the feeding end does not cause problems. You can use a rotary shovel to scrape the mandrel or the corresponding broom brush to clean the inside of the opening of the capsule blank. The end of the capsule blank is closed in a similar procedure as described above with respect to the closure of the first end of the capsule blank. After the adhesive used in the sealing process is hardened, a part of its sealing portion can be similarly cut off to finish the end of the capsule After these process stages, the finished rucksacks are transported through a known process to clean, dry, inspect, pack and sterilize the capsules (please pay attention to this item on the back of the moraine and fill out this page) • ^ · Line. Printed by the Central Bureau of Standards of the Ministry of Economic Affairs _τ, its> * »0 The description of the picture section Μ shadow fine investment and large progress towards the release of the Chinese product of this product. The bucket will be filled out with spare photos and materials, and it will be sent to the center to show the first and second grades of the following text. Figure A 4 (210Χ297 Gongshou) 200403 A6 B6 Printed by the Central Bureau of Standards of the Ministry of Economy V. Invention description () 3 The materials v batched on the trough tray 2 1 are wheeled into the loading hopper 2 3 placed in a horizontal row under the rear edge of the trough tray 2 1. Below these charging funnels, there is a row of capsule blanks 7 carried by the jaws 6 and the lower end of the capsule blank is closed and it is advantageous that the lower end has been finished. The ballast 24 includes feeders in the same number as the charging funnel 23. Each feeder has a rotating motor 25, a rotating shaft 26, and a screw feeder mounted on the lower end of the rotating shaft. In order to make the screw feeder work under the conditions determined by the small size of the capsule to be filled, the charging screw is made of a thin coil spring. In order to facilitate the control of the movement of the coil spring, another straight guide wire is placed in the spring, which extends substantially along the entire length b of the coil spring. The feed spiral 27 made of the spiral spring is guided through the charging funnel 23 to reach the capsule blank below it, and is rotated. The rotation action must select the feeding direction of the spiral spring. The feed screw rotates in the capsule blank to effectively feed the material fed into the charging funnel into the mash blank. In order to prevent unnecessary compression of the material in the capsule blank, the feeding screw is increased during the filling process. After the batch is completely transported, the feed screw has been completely lifted out of the bladder blank, and then the blank is transferred to close it. Before closing, the inside of the opening area can be cleaned to remove any remaining filling material. Seal with adhesive. The method is the same as sealing the blank S end before filling. After sealing, it can be finished by shearing and refining the sac-filled end. After finishing, the finished capsules are taken out of their jaws and jaws, and then processed according to the prior art briefly discussed in seven. ............ .............................. Pretend .................. ................. hit ......................... line (please read first Note on the back and then fill out this page) A4 (210X297 public) 200403 A6 B6 V. Description of the invention (,) 4 There are some components in Figure 1, because it has nothing to do with the scope of the patent application of the present invention, so it is not further described. Please refer to Patent Application No. 81 103143 for relevant description. {Please read the precautions on the back before filling in this page) • Line · Printed by the Central Bureau of Standards of the Ministry of Economics Armor 4 (210X 297 public)