TR2023018952A2 - CONSTRUCTION OF AN ALLERGEN-FREE FRAGRANCE COMPOSITION - Google Patents
CONSTRUCTION OF AN ALLERGEN-FREE FRAGRANCE COMPOSITIONInfo
- Publication number
- TR2023018952A2 TR2023018952A2 TR2023/018952 TR2023018952A2 TR 2023018952 A2 TR2023018952 A2 TR 2023018952A2 TR 2023/018952 TR2023/018952 TR 2023/018952 TR 2023018952 A2 TR2023018952 A2 TR 2023018952A2
- Authority
- TR
- Turkey
- Prior art keywords
- baby
- essence
- super
- iso
- odor
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract description 73
- 239000003205 fragrance Substances 0.000 title abstract description 11
- 238000010276 construction Methods 0.000 title description 2
- 239000013566 allergen Substances 0.000 abstract description 10
- 150000001875 compounds Chemical class 0.000 abstract description 10
- 239000002994 raw material Substances 0.000 abstract description 8
- FVUGZKDGWGKCFE-UHFFFAOYSA-N 1-(2,3,8,8-tetramethyl-1,3,4,5,6,7-hexahydronaphthalen-2-yl)ethanone Chemical compound CC1(C)CCCC2=C1CC(C(C)=O)(C)C(C)C2 FVUGZKDGWGKCFE-UHFFFAOYSA-N 0.000 abstract 1
- 239000000686 essence Substances 0.000 description 107
- 239000002453 shampoo Substances 0.000 description 51
- FVUGZKDGWGKCFE-BDJLRTHQSA-N iso e super Chemical compound CC1(C)CCCC2=C1C[C@](C(C)=O)(C)[C@H](C)C2 FVUGZKDGWGKCFE-BDJLRTHQSA-N 0.000 description 48
- 239000003599 detergent Substances 0.000 description 41
- 239000007788 liquid Substances 0.000 description 35
- 239000000047 product Substances 0.000 description 35
- 238000005406 washing Methods 0.000 description 32
- 230000002009 allergenic effect Effects 0.000 description 31
- 239000004744 fabric Substances 0.000 description 25
- 238000012360 testing method Methods 0.000 description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 19
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 14
- 229940022663 acetate Drugs 0.000 description 14
- 238000011156 evaluation Methods 0.000 description 12
- 238000000034 method Methods 0.000 description 10
- 238000004458 analytical method Methods 0.000 description 8
- 239000002537 cosmetic Substances 0.000 description 8
- 230000001953 sensory effect Effects 0.000 description 8
- YPZUZOLGGMJZJO-UHFFFAOYSA-N Ambronide Chemical compound C1CC2C(C)(C)CCCC2(C)C2C1(C)OCC2 YPZUZOLGGMJZJO-UHFFFAOYSA-N 0.000 description 7
- 238000009472 formulation Methods 0.000 description 7
- PRNCMAKCNVRZFX-UHFFFAOYSA-N 3,7-dimethyloctan-1-ol Chemical compound CC(C)CCCC(C)CCO PRNCMAKCNVRZFX-UHFFFAOYSA-N 0.000 description 6
- 239000007795 chemical reaction product Substances 0.000 description 6
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 6
- ZRSNZINYAWTAHE-UHFFFAOYSA-N p-methoxybenzaldehyde Chemical compound COC1=CC=C(C=O)C=C1 ZRSNZINYAWTAHE-UHFFFAOYSA-N 0.000 description 6
- 238000011056 performance test Methods 0.000 description 6
- 230000002688 persistence Effects 0.000 description 6
- TVDSBUOJIPERQY-UHFFFAOYSA-N prop-2-yn-1-ol Chemical compound OCC#C TVDSBUOJIPERQY-UHFFFAOYSA-N 0.000 description 6
- 238000006467 substitution reaction Methods 0.000 description 5
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 4
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 4
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 4
- CBOQJANXLMLOSS-UHFFFAOYSA-N ethyl vanillin Chemical compound CCOC1=CC(C=O)=CC=C1O CBOQJANXLMLOSS-UHFFFAOYSA-N 0.000 description 4
- 229930002839 ionone Natural products 0.000 description 4
- 150000002499 ionone derivatives Chemical class 0.000 description 4
- UWKAYLJWKGQEPM-LBPRGKRZSA-N linalyl acetate Chemical compound CC(C)=CCC[C@](C)(C=C)OC(C)=O UWKAYLJWKGQEPM-LBPRGKRZSA-N 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 239000000344 soap Substances 0.000 description 4
- 229940116752 vetiveria zizanioides root extract Drugs 0.000 description 4
- KUZMAEUMYSXKOU-UHFFFAOYSA-N 1-(2,6,6-trimethylcyclohex-2-en-1-yl)pentan-3-one Chemical compound CCC(=O)CCC1C(C)=CCCC1(C)C KUZMAEUMYSXKOU-UHFFFAOYSA-N 0.000 description 3
- -1 Dipropylene 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3 - pentanone Chemical compound 0.000 description 3
- 230000033228 biological regulation Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- FINOAUDUYKVGDS-UHFFFAOYSA-N (2-tert-butylcyclohexyl) acetate Chemical compound CC(=O)OC1CCCCC1C(C)(C)C FINOAUDUYKVGDS-UHFFFAOYSA-N 0.000 description 2
- YJRODKCOICMRBO-BQYQJAHWSA-N (e)-4-(2,2,6-trimethylcyclohexyl)but-3-en-2-one Chemical compound CC1CCCC(C)(C)C1\C=C\C(C)=O YJRODKCOICMRBO-BQYQJAHWSA-N 0.000 description 2
- GQBVHGLNSHPKPG-UHFFFAOYSA-N 1-(2-tert-butylcyclohexyl)oxybutan-2-ol Chemical compound CCC(O)COC1CCCCC1C(C)(C)C GQBVHGLNSHPKPG-UHFFFAOYSA-N 0.000 description 2
- GSSXLFACIJSBOM-UHFFFAOYSA-N 2h-pyran-2-ol Chemical compound OC1OC=CC=C1 GSSXLFACIJSBOM-UHFFFAOYSA-N 0.000 description 2
- DLHQZZUEERVIGQ-UHFFFAOYSA-N 3,7-dimethyl-3-octanol Chemical compound CCC(C)(O)CCCC(C)C DLHQZZUEERVIGQ-UHFFFAOYSA-N 0.000 description 2
- MBZRJSQZCBXRGK-UHFFFAOYSA-N 4-tert-Butylcyclohexyl acetate Chemical compound CC(=O)OC1CCC(C(C)(C)C)CC1 MBZRJSQZCBXRGK-UHFFFAOYSA-N 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Chemical compound CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- JOZKFWLRHCDGJA-UHFFFAOYSA-N citronellol acetate Chemical compound CC(=O)OCCC(C)CCC=C(C)C JOZKFWLRHCDGJA-UHFFFAOYSA-N 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 229940019836 cyclamen aldehyde Drugs 0.000 description 2
- BLBJUGKATXCWET-UHFFFAOYSA-N cyclaprop Chemical compound C12CC=CC2C2CC(OC(=O)CC)C1C2 BLBJUGKATXCWET-UHFFFAOYSA-N 0.000 description 2
- 229930008394 dihydromyrcenol Natural products 0.000 description 2
- XSNQECSCDATQEL-UHFFFAOYSA-N dihydromyrcenol Chemical compound C=CC(C)CCCC(C)(C)O XSNQECSCDATQEL-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- MTZQAGJQAFMTAQ-UHFFFAOYSA-N ethyl benzoate Chemical compound CCOC(=O)C1=CC=CC=C1 MTZQAGJQAFMTAQ-UHFFFAOYSA-N 0.000 description 2
- 229940073505 ethyl vanillin Drugs 0.000 description 2
- IFYYFLINQYPWGJ-UHFFFAOYSA-N gamma-decalactone Chemical compound CCCCCCC1CCC(=O)O1 IFYYFLINQYPWGJ-UHFFFAOYSA-N 0.000 description 2
- 230000000774 hypoallergenic effect Effects 0.000 description 2
- UWKAYLJWKGQEPM-UHFFFAOYSA-N linalool acetate Natural products CC(C)=CCCC(C)(C=C)OC(C)=O UWKAYLJWKGQEPM-UHFFFAOYSA-N 0.000 description 2
- VAMXMNNIEUEQDV-UHFFFAOYSA-N methyl anthranilate Chemical compound COC(=O)C1=CC=CC=C1N VAMXMNNIEUEQDV-UHFFFAOYSA-N 0.000 description 2
- KVWWIYGFBYDJQC-UHFFFAOYSA-N methyl dihydrojasmonate Chemical compound CCCCCC1C(CC(=O)OC)CCC1=O KVWWIYGFBYDJQC-UHFFFAOYSA-N 0.000 description 2
- BOPPSUHPZARXTH-UHFFFAOYSA-N ocean propanal Chemical compound O=CC(C)CC1=CC=C2OCOC2=C1 BOPPSUHPZARXTH-UHFFFAOYSA-N 0.000 description 2
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 2
- FDPIMTJIUBPUKL-UHFFFAOYSA-N pentan-3-one Chemical compound CCC(=O)CC FDPIMTJIUBPUKL-UHFFFAOYSA-N 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 229940067107 phenylethyl alcohol Drugs 0.000 description 2
- 230000037307 sensitive skin Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- ZFNVDHOSLNRHNN-UHFFFAOYSA-N xi-3-(4-Isopropylphenyl)-2-methylpropanal Chemical compound O=CC(C)CC1=CC=C(C(C)C)C=C1 ZFNVDHOSLNRHNN-UHFFFAOYSA-N 0.000 description 2
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 1
- KHWTYGFHPHRQMP-UHFFFAOYSA-N (4-propan-2-ylcyclohexyl)methanol Chemical compound CC(C)C1CCC(CO)CC1 KHWTYGFHPHRQMP-UHFFFAOYSA-N 0.000 description 1
- KRLBLPBPZSSIGH-CSKARUKUSA-N (6e)-3,7-dimethylnona-1,6-dien-3-ol Chemical compound CC\C(C)=C\CCC(C)(O)C=C KRLBLPBPZSSIGH-CSKARUKUSA-N 0.000 description 1
- UFLHIIWVXFIJGU-ARJAWSKDSA-N (Z)-hex-3-en-1-ol Chemical compound CC\C=C/CCO UFLHIIWVXFIJGU-ARJAWSKDSA-N 0.000 description 1
- KHQDWCKZXLWDNM-KPKJPENVSA-N (e)-2-ethyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)but-2-en-1-ol Chemical compound CC\C(CO)=C/CC1CC=C(C)C1(C)C KHQDWCKZXLWDNM-KPKJPENVSA-N 0.000 description 1
- RNLHVODSMDJCBR-VURMDHGXSA-N (z)-3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pent-4-en-2-ol Chemical compound CC(O)C(C)\C=C/C1CC=C(C)C1(C)C RNLHVODSMDJCBR-VURMDHGXSA-N 0.000 description 1
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 1
- MTNZPWYMBRSDTL-UHFFFAOYSA-N 1-(3-methyl-1-benzofuran-2-yl)ethanone Chemical compound C1=CC=C2C(C)=C(C(=O)C)OC2=C1 MTNZPWYMBRSDTL-UHFFFAOYSA-N 0.000 description 1
- AROCNZZBLCAOPH-UHFFFAOYSA-N 1-methyl-4-prop-2-enoxybenzene Chemical compound CC1=CC=C(OCC=C)C=C1 AROCNZZBLCAOPH-UHFFFAOYSA-N 0.000 description 1
- YMNMXSGJWUJWNW-UHFFFAOYSA-N 2-(2-hydroxypropoxy)propan-1-ol;3-(3-hydroxypropoxy)propan-1-ol Chemical compound CC(O)COC(C)CO.OCCCOCCCO YMNMXSGJWUJWNW-UHFFFAOYSA-N 0.000 description 1
- DNRJTBAOUJJKDY-UHFFFAOYSA-N 2-Acetyl-3,5,5,6,8,8-hexamethyl-5,6,7,8- tetrahydronaphthalene Chemical compound CC(=O)C1=C(C)C=C2C(C)(C)C(C)CC(C)(C)C2=C1 DNRJTBAOUJJKDY-UHFFFAOYSA-N 0.000 description 1
- FNEWGEWRECZWQM-UHFFFAOYSA-N 2-Ethoxy-4-(methoxymethyl)phenol Chemical compound CCOC1=CC(COC)=CC=C1O FNEWGEWRECZWQM-UHFFFAOYSA-N 0.000 description 1
- LUZDYPLAQQGJEA-UHFFFAOYSA-N 2-Methoxynaphthalene Chemical compound C1=CC=CC2=CC(OC)=CC=C21 LUZDYPLAQQGJEA-UHFFFAOYSA-N 0.000 description 1
- FLUWAIIVLCVEKF-UHFFFAOYSA-N 2-Methyl-1-phenyl-2-propanyl acetate Chemical compound CC(=O)OC(C)(C)CC1=CC=CC=C1 FLUWAIIVLCVEKF-UHFFFAOYSA-N 0.000 description 1
- CFAKWWQIUFSQFU-UHFFFAOYSA-N 2-hydroxy-3-methylcyclopent-2-en-1-one Chemical compound CC1=C(O)C(=O)CC1 CFAKWWQIUFSQFU-UHFFFAOYSA-N 0.000 description 1
- ZHDQGHCZWWDMRS-UHFFFAOYSA-N 3,5-dimethylcyclohex-3-ene-1-carbaldehyde Chemical compound CC1CC(C=O)CC(C)=C1 ZHDQGHCZWWDMRS-UHFFFAOYSA-N 0.000 description 1
- DHJVLXVXNFUSMU-UHFFFAOYSA-N 3,7-dimethylnona-2,6-dienenitrile Chemical compound CCC(C)=CCCC(C)=CC#N DHJVLXVXNFUSMU-UHFFFAOYSA-N 0.000 description 1
- MTDAKBBUYMYKAR-UHFFFAOYSA-N 3,7-dimethyloct-6-enenitrile Chemical compound N#CCC(C)CCC=C(C)C MTDAKBBUYMYKAR-UHFFFAOYSA-N 0.000 description 1
- JFTSYAALCNQOKO-UHFFFAOYSA-N 3-(4-ethylphenyl)-2,2-dimethylpropanal Chemical compound CCC1=CC=C(CC(C)(C)C=O)C=C1 JFTSYAALCNQOKO-UHFFFAOYSA-N 0.000 description 1
- GTNCESCYZPMXCJ-UHFFFAOYSA-N 3-Phenylpropyl propanoate Chemical compound CCC(=O)OCCCC1=CC=CC=C1 GTNCESCYZPMXCJ-UHFFFAOYSA-N 0.000 description 1
- NGYMOTOXXHCHOC-UHFFFAOYSA-N 3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol Chemical compound CC(O)C(C)CCC1CC=C(C)C1(C)C NGYMOTOXXHCHOC-UHFFFAOYSA-N 0.000 description 1
- BGTBFNDXYDYBEY-FNORWQNLSA-N 4-(2,6,6-Trimethylcyclohex-1-enyl)but-2-en-4-one Chemical compound C\C=C\C(=O)C1=C(C)CCCC1(C)C BGTBFNDXYDYBEY-FNORWQNLSA-N 0.000 description 1
- TZJLGGWGVLADDN-UHFFFAOYSA-N 4-(3,4-Methylenedioxyphenyl)-2-butanone Chemical compound CC(=O)CCC1=CC=C2OCOC2=C1 TZJLGGWGVLADDN-UHFFFAOYSA-N 0.000 description 1
- HFNGYHHRRMSKEU-UHFFFAOYSA-N 4-Methoxybenzyl acetate Chemical compound COC1=CC=C(COC(C)=O)C=C1 HFNGYHHRRMSKEU-UHFFFAOYSA-N 0.000 description 1
- GHBSPIPJMLAMEP-UHFFFAOYSA-N 6-pentyloxan-2-one Chemical compound CCCCCC1CCCC(=O)O1 GHBSPIPJMLAMEP-UHFFFAOYSA-N 0.000 description 1
- AZUVBPVDRHGGEP-UHFFFAOYSA-N 6a,9a-dimethyl-4,5,7,8,9,9a-hexahydro-6aH-dipyrrolo(2,3-b;3',2',1'-hi)indole Natural products CC(=C)C1CCC(C)=CCCC(C)=CCCC(C)=CC1O AZUVBPVDRHGGEP-UHFFFAOYSA-N 0.000 description 1
- NVEQFIOZRFFVFW-UHFFFAOYSA-N 9-epi-beta-caryophyllene oxide Natural products C=C1CCC2OC2(C)CCC2C(C)(C)CC21 NVEQFIOZRFFVFW-UHFFFAOYSA-N 0.000 description 1
- JOZKFWLRHCDGJA-LLVKDONJSA-N Citronellyl acetate Natural products CC(=O)OCC[C@H](C)CCC=C(C)C JOZKFWLRHCDGJA-LLVKDONJSA-N 0.000 description 1
- 244000304337 Cuminum cyminum Species 0.000 description 1
- 235000007129 Cuminum cyminum Nutrition 0.000 description 1
- HZPKNSYIDSNZKW-UHFFFAOYSA-N Ethyl 2-methylpentanoate Chemical compound CCCC(C)C(=O)OCC HZPKNSYIDSNZKW-UHFFFAOYSA-N 0.000 description 1
- YIKYNHJUKRTCJL-UHFFFAOYSA-N Ethyl maltol Chemical compound CCC=1OC=CC(=O)C=1O YIKYNHJUKRTCJL-UHFFFAOYSA-N 0.000 description 1
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 description 1
- 235000015511 Liquidambar orientalis Nutrition 0.000 description 1
- WSTYNZDAOAEEKG-UHFFFAOYSA-N Mayol Natural products CC1=C(O)C(=O)C=C2C(CCC3(C4CC(C(CC4(CCC33C)C)=O)C)C)(C)C3=CC=C21 WSTYNZDAOAEEKG-UHFFFAOYSA-N 0.000 description 1
- MSFLYJIWLHSQLG-UHFFFAOYSA-N Octahydro-2H-1-benzopyran-2-one Chemical compound C1CCCC2OC(=O)CCC21 MSFLYJIWLHSQLG-UHFFFAOYSA-N 0.000 description 1
- 239000004870 Styrax Substances 0.000 description 1
- 244000028419 Styrax benzoin Species 0.000 description 1
- 235000000126 Styrax benzoin Nutrition 0.000 description 1
- 239000005844 Thymol Substances 0.000 description 1
- 244000284012 Vetiveria zizanioides Species 0.000 description 1
- 235000007769 Vetiveria zizanioides Nutrition 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- FAMPSKZZVDUYOS-UHFFFAOYSA-N alpha-Caryophyllene Natural products CC1=CCC(C)(C)C=CCC(C)=CCC1 FAMPSKZZVDUYOS-UHFFFAOYSA-N 0.000 description 1
- YPZUZOLGGMJZJO-LQKXBSAESA-N ambroxan Chemical compound CC([C@@H]1CC2)(C)CCC[C@]1(C)[C@@H]1[C@]2(C)OCC1 YPZUZOLGGMJZJO-LQKXBSAESA-N 0.000 description 1
- 229940062909 amyl salicylate Drugs 0.000 description 1
- RFRXIWQYSOIBDI-UHFFFAOYSA-N benzarone Chemical compound CCC=1OC2=CC=CC=C2C=1C(=O)C1=CC=C(O)C=C1 RFRXIWQYSOIBDI-UHFFFAOYSA-N 0.000 description 1
- 125000005605 benzo group Chemical group 0.000 description 1
- NPNUFJAVOOONJE-UHFFFAOYSA-N beta-cariophyllene Natural products C1CC(C)=CCCC(=C)C2CC(C)(C)C21 NPNUFJAVOOONJE-UHFFFAOYSA-N 0.000 description 1
- 229940116229 borneol Drugs 0.000 description 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 1
- 229940117948 caryophyllene Drugs 0.000 description 1
- NPNUFJAVOOONJE-UONOGXRCSA-N caryophyllene Natural products C1CC(C)=CCCC(=C)[C@@H]2CC(C)(C)[C@@H]21 NPNUFJAVOOONJE-UONOGXRCSA-N 0.000 description 1
- 229960005233 cineole Drugs 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 229940095104 dimethyl benzyl carbinyl acetate Drugs 0.000 description 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 1
- VQNUNMBDOKEZHS-UHFFFAOYSA-N ethoxymethoxycyclododecane Chemical compound CCOCOC1CCCCCCCCCCC1 VQNUNMBDOKEZHS-UHFFFAOYSA-N 0.000 description 1
- 239000001449 ethyl (2R)-2-methylpentanoate Substances 0.000 description 1
- NYNCZOLNVTXTTP-UHFFFAOYSA-N ethyl 2-(1,3-dioxoisoindol-2-yl)acetate Chemical compound C1=CC=C2C(=O)N(CC(=O)OCC)C(=O)C2=C1 NYNCZOLNVTXTTP-UHFFFAOYSA-N 0.000 description 1
- 229940093503 ethyl maltol Drugs 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- IFYYFLINQYPWGJ-VIFPVBQESA-N gamma-Decalactone Natural products CCCCCC[C@H]1CCC(=O)O1 IFYYFLINQYPWGJ-VIFPVBQESA-N 0.000 description 1
- HIGQPQRQIQDZMP-UHFFFAOYSA-N geranil acetate Natural products CC(C)=CCCC(C)=CCOC(C)=O HIGQPQRQIQDZMP-UHFFFAOYSA-N 0.000 description 1
- HIGQPQRQIQDZMP-DHZHZOJOSA-N geranyl acetate Chemical compound CC(C)=CCC\C(C)=C\COC(C)=O HIGQPQRQIQDZMP-DHZHZOJOSA-N 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- UFLHIIWVXFIJGU-UHFFFAOYSA-N hex-3-en-1-ol Natural products CCC=CCCO UFLHIIWVXFIJGU-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- ZNJFBWYDHIGLCU-HWKXXFMVSA-N jasmonic acid Chemical compound CC\C=C/C[C@@H]1[C@@H](CC(O)=O)CCC1=O ZNJFBWYDHIGLCU-HWKXXFMVSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 229940102398 methyl anthranilate Drugs 0.000 description 1
- HRGPYCVTDOECMG-RHBQXOTJSA-N methyl cedryl ether Chemical compound C1[C@@]23[C@H](C)CC[C@H]2C(C)(C)[C@]1([H])[C@@](OC)(C)CC3 HRGPYCVTDOECMG-RHBQXOTJSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000001738 pogostemon cablin oil Substances 0.000 description 1
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 229940095673 shampoo product Drugs 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- NPNUFJAVOOONJE-ZIAGYGMSSA-N trans-caryophyllene Natural products C1CC(C)=CCCC(=C)[C@H]2CC(C)(C)[C@@H]21 NPNUFJAVOOONJE-ZIAGYGMSSA-N 0.000 description 1
Abstract
Buluş, Avrupa Birliği nezdinde yeni alerjen esans hammaddesi olarak eklenen 1-(2,3,8,8-tetramethyl-1,3,4,5,6,7-hexahydronaphthalen-2-yl)ethanone (Iso e super) bileşiğine alternatif olarak geliştirilen alerjen içermeyen bir koku kompozisyonu yapılanması ile ilgilidir.The invention is an alternative to 1-(2,3,8,8-tetramethyl-1,3,4,5,6,7-hexahydronaphthalen-2-yl)ethanone (Iso e super) compound, which was added as a new allergen essence raw material in the European Union. It is about structuring an allergen-free fragrance composition developed as.
Description
TARIFNAME ALERJEN IÇERMEYEN BIR KOKU KOMPOZISYONU YAPILANMASI Teknik Alan Bulus, Avrupa Birligi nezdinde yeni alerjen esans hammaddesi olarak eklenen 1- alternatif olarak gelistirilen alerj en içermeyen bir koku kompozisyonu yapilanmasi ile ilgilidir. Teknigin Bilinen Durumu Avrupa Birligi Parlamentosuanun 1223/2009 numarali yönetmeliginde belirlenmis kozmetik ürünlerinde kullanilan 26 alerjen esans hammaddesine yeni alerjen esans hammaddelerinin naftil)etan-1-on (Iso e super) bilesigi de eklenmektedir. Söz konusu bilesigin, kozmetik alaninda ve özellikle bebek ürünlerinin de içlerinde yer aldigi hassas ciltli kisiler için üretilen kisisel bakim ürünlerinde kullanimlari kisitlanmaktadir. Böylelikle söz konusu alanlarda alerj en içermeyen yeni kompozisyonlarin gelistirilmesi gerekmektedir. Teknigin bilinen durumunda yer alan kompozisyonlarin içerdikleri bilesikler, özellikle bebek sampuani, bebek sivi deterjani ve bebek yumusaticisi gibi ürünlerde yikama sirasinda sicak su ile çözünüp ortamdan uzaklasmaktadir. Bu da söz konusu uygulamalarda kalici koku özelligini azaltmaktadir. Mevcut teknikte, güncellenen Avrupa Birligi kozmetik yönetmeligine göre kozmetik ürünlerde (sampuan, sabun ve dolayli olarak cilt hassasiyeti oldugu için ve bebek ile ilgili olan çogu ürün için de geçerli olmak üzere) hipoalerjenik ürünler üretilmektedir. Hipoalerjenik ürünlerde de alerj en içerik olmamasi veya bu yönetmelikte belirlenen limitlerin altinda olmasi gerekmektedir. Sampuan, sabun gibi su ile durulanan ürünlerde her bir alerj en için maksimum miktar 100 ppmdir. 100 ppm üzerinde ise alerj en madde ürün etiketinde belirtilmek zorundadir. Benzer sekilde durulanmayan (parlüm, bebek yagi, bebek losyonu, islak mendil vb.) ürünlerde ise her bir alerj en madde için maksimum miktar 10 ppm,dir. 10 ppm üzerinde ise ayni sekilde ürün etiketinde belirtilmek zorundadir. Bazi ürün üreticileri ise 100 ppm ve 10 ppm konsantrasyonlarina bakmaksizin alerjen içerigini 0 ppm istemektedir. Bu sebeple alerjen olmayan ve kalici koku özelligine sahip yeni kompozisyonlarin gelistirilmesi gereklidir. karvomentondan farkli en az bir koku ve kozmetik açidan kabul edilebilir en az bir tasiyici içeren gelistirilmis koku profiline sahip parfüm yaglari alaninda yer alan kompozisyonlar ile ve arzu edilen koku özelliklerine sahip yeni bilesiklerin sentezi ve uygulamasi ile ilgilidir. Bulusun Kisa Açiklamasi Mevcut bulus yukarida bahsedilen dezavantajlari ortadan kaldirmak ve ilgili teknik alana yeni avantajlar saglamak üzere; Avrupa Birligi nezdinde yeni alerj en esans hammaddesi bilesigine alternatif olarak gelistirilen alerjen içermeyen bir koku kompozisyonu yapilanmasi ile ilgilidir. Bulus ile alerjen olmayan esans formülasyonlarina yeni bir kompozisyon gelistirmesi saglanmaktadir. Ayrica, Avrupa Birligi Standartlarina uygun alerjen içermeyen ürünler gelistirilmektedir. Bulus ile alerjen bilesenlerin istenmedigi veya kisitlandigi bebek sampuani gibi kozmetik ürünlerde alerjen olmayan bir alternatif kompozisyon ve ayni zamanda kozmetik ürünü olmayan ve bebekler için kullanilacak bebek deterjani, bebek yumusaticisi gibi diger ürün gruplarinda da alerj en olmayan alternatif bir kompozisyon elde edilmektedir. Bulus konusu kompozisyon, bebek sampuani, bebek sivi deterjani ve bebek yumusaticisi gibi ürünlerde kumas yikama islemlerinin test edilmesi ve yapilan duyusal analizler ile kumasta kokunun daha fazla kaldigi kanitlanmaktadir. Böylelikle bulus ile kalici ve alerj en olmayan bir koku kompozisyonu elde edilmektedir. Bulusun Detayli Açiklamasi Örnek düzenlemeler asagida eslik eden açiklamalara atifta bulunmak sureti ile daha detayli olarak tarif edilmektedir. Bununla birlikte, düzenlemeler farkli biçimlerde olusturulabilir ve burada belirtilen düzenlemelerle sinirli olarak yorumlanmamalidir. Bunun yerine, bu örnek düzenlemeler, bu açiklamanin eksiksiz olmasi ve kapsaminin teknikte uzman kisilere tam olarak iletilmesi için saglanmistir. Bu tarifnamede kullanilan terminolojinin sadece özel bir örnek düzenlemeleri tarif etmek amaciyla kullanilmasi ve sinirlayici olmamasi amaçlanmistir. Burada kullanildigi sekliyle, "bir", "en az", "tercihen" ve "ve/veya" biçimlerinin baglami, açikça aksi belirtilmedigi sürece çogul biçimleri de içermektedir. Bulus, Avrupa Birligi nezdinde yeni alerjen esans hammaddesi olarak eklenen 1- alternatif olarak gelistirilen alerjen içermeyen bir koku kompozisyonu yapilanmasi ile ilgili olup; l-(2-teit-butylcyclohexyl)oxybutan-2-ol (Ambercore), 3A,6,6,9A- Tetrametildodekahidronafto [2, 1 -B] furan (AmbrofiX), (lR,ZS ,5 R,8 S)-4,4, 8- Trimetiltrisiklo(6.3.l.02,5)-dodekan-l-il asetat (Caryophylene acetate), 3-(3- hydroxypropoxy)propan-l-ol (Dipropylene glycol), l-(2,6,6-trimetil-2-siklohekzen-l-il)-3- pentanon, 2-propin-l-ol ile reaksiyon ürünleri (Grisalva), (4-tert-butylcyclohexyl) acetate (PTBCH acetate) ve vetiveria zizanioides kök ekstresi asetati (Vetiver acetate eX-haiti) içermektedir. Bulus konusu koku kompozisyonu yapilanmasi; - Agirlikça %0,4-2 oraninda l-(2-tert-butylcyclohexyl)oxybutan-2-ol, - Agirlikça %0,l-0,7 oraninda 3A,6,6,9A-Tetrametildodekahidronafto[2,l-B]furan, - Agirlikça %85-95 oraninda 3-(3-hydroxypropoxy)propan-l-ol, - Agirlikça %0,5-2 oraninda l-(2,6,6-trimetil-2-siklohekzen-l-il)-3-pentanon, 2-propin- l-ol ile reaksiyon ürünleri, - Agirlikça %0,03-0,5 oraninda (4-tert-butylcyclohexyl) acetate, - Agirlikça %0,l-0,7 oraninda vetiveria zizanioides kök ekstresi asetati içermektedir. Bulusun bir uygulamasinda söz konusu kompozisyon yapilanma oranlari Tablo 1,de verilmektedir; Tablo 1. Kompozisyon Içerikleri Ticari isim Isim Numarasi Oran Amber core Amber butanol AmbrofiX 3A,6,6,9A-Tetrametildodekahidronafto[2, 1 - B]furan Ambroxide (1R,2S,5R,8S)-4,4,8- Caryophyllene _ _ _ _ _ Dipropylene 1-(2,6,6-trimetil-2-siklohekzen-1-il)-3 - pentanon, 2-propin-1-ol ile reaksiyon Grisalva ürünleri Amber Furan (3 -Pentanone, 1-(2,6,6-trimethyl-2- cyclohexen-l-yl)-, reaction products With 2- propyn-1-ol) PTBCH asetat VeiIeneX Cyclohexyl Vetiver acetate _ _ _ _ _ _ Tablo 1 ,de de belirtildigi üzere bulus konusu kompozisyonun bir uygulamasinda içerik oranlari; - agirlikça % 0,8 oraninda l-(2-tert-butylcyclohexyl)oxybutan-2-ol, - agirlikça % 0,35 oraninda 3A,6,6,9A-Tetrametildodekahidronafto[2, l -B]furan octahydro- 1 H benzo[e] [ l ]benzofuran, - agirlikça %92,85 oraninda 3-(3-hydroxypropoxy)propan- l -ol, - agirlikça %1 ,5 oraninda l-(2,6,6-trimetil-2-siklohekzen- l -il)-3-pentanon, 2-propin- l -ol ile reaksiyon ürünleri, - agirlikça %0,3 oraninda (4-tert-butylcyclohexyl) acetate, - agirlikça %0,2 oraninda vetiveria Zizanioides kök ekstresi asetati,dir. kaliciligini saglamak için genel olarak log p=3 ve üzeri degerlerdeki moleküller uygun olmakla birlikte tercihen log p=4 ve üzeri olan moleküller daha da iyi bir koku kaliciligi saglamaktadir. Bu sebeple bulus konusu ikame kompozisyonda bu kriterler göz önünde bulundurularak hammaddeler belirlenmis ve test edilmistir. Bulusta yumusak amberimsi koku profilini saglayabilmek için amber core (l-(2-tert- butylcyclohexyl)oxybutan-2-ol) kullanilmaktadir. Ayrica log p degeri yaklasik 5 .65 oldugu için yikamadan sonra kumastaki koku kaliciliginin iso e super ile kiyaslanabilir düzeydedir. Bulusta ambergris koku profilini saglamak için ambrofiX (3A,6,6,9A- Tetrametildodekahidronafto [2,1-B]furan) kullanilmaktadir. Ayrica log p degeri yaklasik 5.411 oldugu için yikamadan sonra kumastaki koku kaliciligi iyi olarak gözlenmektedir. Bulusta sedir agaci ve odunsu koku profilini saglamak için caryophylene asetat ((lR,ZS,5R,SS)- 4,4,8-Trimetiltrisiklo(6.3. l .02,5)-dodekan-l-il asetat) kullanilmaktadir. Ayrica log p degeri yaklasik 5.36 oldugu için yikamadan sonra suda az çözündügünden dolayi kumasta daha fazla kalabilmesi saglanmaktadir. Bulusta dipropylene glycol (3-(3-hydroxypropoxy)propan-l-ol) çözücü olarak kullanilmakta olup, kokusuz özelliktedir. Söz konusu bilesik ile ürün seyreltilmesi ve maliyetten kazanç saglanmaktadir. Bulusta ambergris ve derimsi koku profilini saglamak için grisalva (l-(2,6,6-trimetil-2- siklohekzen- l -il)-3 -pentanon, 2-propin- l -ol ile reaksiyon ürünleri) kullanilmaktadir. Bulusta çiçeksi ve ayni zamanda odunsu, yumusak ve pürüzsüz koku profilini saglamak için PTBCH asetat ((4-teit-butylcyclohexyl) acetate) kullanilmaktadir. Ayrica log p degeri 4.23 oldugu için, iso e superin log p degeri olan 5.65,ten biraz daha düsük olmasina ragmen yikamadan sonra suda daha az çözünerek kalicilik elde edilmektedir. Bulusta, kuru odunsu koku profilini saglamak için vetiveria zizanioides kök ekstresi asetati kullanilmaktadir. Bulusta sayilan bilesik ticari isimlerinin örnek birkaçi verilmektedir. Söz konusu isimler literatüre göre artirilabilir, azaltilabilir veya diger isimleri kullanilabilmektedir. Bulus uygulamada, tarifname içerisinde bahsi geçen ticari isimler ile sinirli degildir. Bulus ile gelistirilen kompozisyon esans ve kozmetik alanlarinda kullanilmaktadir. Ayrica, bebek bakim ürünlerinde; örnegin, bebek deterjani, bebek yumusatici, bebek islak mendili, bebek sampuani, bebek sabunu ve benzer tüm ürünleri, hassas cilt tiplerine sahip kisiler için alerj en içermeyen kisisel veya kisisel olmayan tüm temizlik ve bakim ürünleri, küçük çocuk bakim ürünleri ve mendilleri, islak veya kuru mendiller, deterj anlar, yumusatici, sampuan ve sabun dâhil tüm alerj en içermeyen kozmetik sektörü harici kullaniminda yer alan temizlik ve bakim sektöründe kullanilmaktadir. Bulus konusu kompozisyon eldesi birçok kez yapilan denemeler sonucunda ortaya çikmaktadir. Her bir kompozisyon denemesinde Iso e super bilesigi ile bulus konusu kompozisyon kokusal olarak karsilastirilmistir. Söz konusu deneysel asamalar sonrasi yukarida belirtilen içerikler ve oranlar ortaya çikmistir. 3 yol tercih edilmistir. Ilk yol olarak, iso e super ile alternatif kompozisyonun yag halinde kokusal olarak kiyaslanmasi ve parfümeri terminolojisine göre yorumlanmaktadir. Ikinci yol olarak, iso e super içeren ve içermeyen (yerine gelistirilen alternatif kompozisyonu içeren) esans formülasyonlarinin bebek sampuani, bebek yumusaticisi ve bebek siVi deterjani içerisine uygulandiktan sonra kokular kiyaslanmaktadir. Son yol olarak ise gelistirilen esanslarin bebek sampuani, bebek siVi deterjani ve bebek yumusaticisina uygulandiktan sonra yikama testleri yapilarak koku kaliciliklari kiyaslanmaktadir. Burada bebek sampuani içerisinde degerlendirilirken beher içerisine 35-40°C,de su konulup içerisine sampuanin belli miktarda eklenmesi, homojen hale getirilmesi ve sicak sudan koku yayiliminin karsilastirilmasi; sonrasinda bu suyun içerisine belli miktarda gerçek saç konularak sampuanli suyun saça emdirilmesi; daha sonra sudan çikartilip saçtaki koku kaliciliginin degerlendirilmesi seklinde yapilmaktadir. Sivi deterjan ve yumusatici için ise öncelikle esans siVi deterjan ve yumusatici haline getirildikten sonra siseden; sonra da bu siVi deterjan ve yumusatici ile belli adette, farkli tekstil kumaslarini içerecek sekilde çamasir makinelerinde es zamanli yikama testi yapilmaktadir. Söz konusu yikama testinden sonra da kokunun islak kumastaki kaliciligi kiyaslanmaktadir. Bulus konusu kompozisyonun içerdigi esanslar bebek sampuani, bebek siVi deterjani ve bebek konsantre yumusaticisi olarak 3 ayri kategoride degerlendirilmistir. Her bir ürün kategorisindeki esans içinde bulunan iso e super isimli bilesik yerine alerjen olmayan iso e super alternatifi kompozisyon ayni konsantrasyonda kullanilmistir. Söz konusu 3 ayri tüketici ürünü kategorisinde iso e super ve iso e super yerine ikame edilen bulus konusu kompozisyonun karsilastirmali olarak degerlendirilecegi esans formülasyon içerikleri ve oranlari Tablo 2, Tablo Bebek sampuanindaki koku performansini degerlendirmek üzere; Tablo 2,de bilesenleri verilen esans formülasyonuna göre, birinde %10 konsantrasyonda iso e super içeren ve digerinde %10 konsantrasyonda iso e super yerine %10 konsantrasyonda alerj en olmayan bulus konusu ikame kompozisyonu içeren iki ayri esans hazirlanmistir. Tablo 2. Bebek Sampuani Esansi Bilesenleri ve Oranlari Bebek Sampuani Esans Bilesenleri Oran (%) Bebek Sampuani Esans Bilesenleri Oran (%) Anisaldehyde 0,700 Iso E super 10,000 Anisyl acetate 0,200 Indolarome 0,050 Benzaldehyde 0,150 Ionone alpha 0,100 Bicyclononlactone 0,5 00 Jessemal 0,100 Cis-3-hexenol 0,050 Lemonile 0,100 Cis-3-hexenyl salicylate 4,000 Linalyl acetate 3,200 Cumin oil %1 DPG,de 0,400 Mayol 1,700 Cyclamen aldehyde 0,650 Methyl cyclopentenolone%1 DPG 0,400 Dihydro ionone beta 0,300 Methyl dihydro jasmonate 10,000 Dihydro myrcenol 3,000 Nerolione 0,030 Dimethyl anthranilate 0,05 0 Piperonyl acetone 0,200 Dimethyl benzyl carbinyl acetate 0,300 Pyranol 1,500 Dipropylene glycol 49,510 Sandalore 0,5 00 Dodecalactone delta 0,100 Strallyl acetate 0,100 Ebanol 0,300 StyraX substitute 0,150 Ethyl maltol 0,050 Tetrahydro geraniol 0,800 Ethyl vanillin 1,500 Tetrahydro linalool 1,300 Gamma decalactone 0,100 Trivertal 0,030 Geranyl acetate 0,700 Verdox 0,200 Helional 0,800 Toplam 100,000 Hazirlanan iki ayri esans standart parû'imsüz bir bebek sampuani bazina %1 konsantrasyonunda uygulanmistir. Hazirlanan iki esansin performans testi uygulamasinda; 250 mL,lik iki beherden birine iso e super içeren esans ile hazirlanmis bebek sampuanindan 2 gr; diger behere de iso e super yerine alerjen olmayan ikame kompozisyonu içeren esans ile hazirlanmis bebek sampuanindan 2 gr hassas terazide tartilmistir. Her iki behere de sicaklik yaklasik olarak 35°C olacak sekilde sicak su eklenerek 250 mL,ye tamamlanmistir. Bir cam baget yardimi ile her iki beherdeki su karistirilarak karisimin homojen hale gelmesi saglanmistir. Her iki beherdeki suyun içerisine agirlikça esit miktarda gerçek saç eklenmis olup, yaklasik 30 saniye boyunca sicak suda bekletilen saçlar beherlerden çikartilmistir. performans testleri açisindan degerlendirilmesi parfümör ve esans analistlerinden olusan 10 kisilik bir panel ekibiyle yapilmistir. Yukaridaki belirtilen islemlerden sonra iso e super içeren esans referans alinarak alerjen olmayan ikame bulus konusu kompozisyonu içeren esans ile asagidaki sekilde karsilastirilmistir; Kokunun sampuandaki yayilimi için; Iso e super ve alerj en olmayan ikame kompozisyon içeren esanslarin kullanildigi bebek sampuanlari siseye yaklasik 2 cm mesafeden koklanarak koku profili ve koku gücü karsilastirilmistir. Kokunun sampuan ile yikanan saçtaki yayilimi için; Iso e super ve alerjen olmayan ikame kompozisyon içeren esanslarin kullanildigi bebek sampuanlarinin kullanilmasiyla hazirlanan sicak suda yikanan saçlar islak halde iken yaklasik 2 cm mesafeden koklanarak koku profili ve Kokunun sicak suda çözünen sampuandaki yayilimi için; iso e super ve alerj en olmayan iso e super yerine ikame kompozisyon içeren esanslarin kullanildigi bebek sampuanlarinin kullanilmasiyla hazirlanan her iki 250 mL,lik beherdeki sicak su koklanarak koku profili ve koku gücü açisindan karsilastirilmistir. kisilik panel ekibi ile 1 ile 5 arasindaki bir puanlama sistemiyle iso e super içeren esansin kullanildigi bebek sampuanini referans alarak alerjen olmayan ikame kompozisyonu içeren esansin kullanildigi bebek sampuani ile karsilastirmistir. Yukarida belirtilen koku degerlendirme kriterlerine göre 10 kisilik panel ekibinin degerlendirme sonuçlari Tablo 3,te verilmektedir. Tablo 3. Bebek Sampuani Puanlama Sistemi Degerlendirme Sonuçlari Kokunun Kokunun sicak Esans sampuandaki yikanan saçtaki sampuandaki Alerj en olmayan ikame kompozisyonu içeren esans Yapilan duyusal analizlerde kabul edilebilir puan alt siniri en az 3 puan olmasi gerekmektedir. Tablo 3,te görüldügü üzere, bulusa konu kompozisyonu içeren esans kokunun sampuandaki yayiliminda 4,306 puana çikarak iso e super içeren esansa göre yakin bir puan elde edilmistir. Kokunun sampuan ile yikanan saçtaki esans yayilimlarinda ise 3,ün üzerinde bir performans göstererek saçta yeterli kalicilik elde edilmektedir. Ayrica, kokunun sicak suda çözünen sampuandaki yayilimi örnek olarak, dus esnasinda sampuan kullaniminda dus suyuyla temas sonucu koku yayilmasi anlamina gelmektedir. Bulus, bir önceki parametrede ki gibi 3,ün üzerinde bir performans göstererek sicak suda koku yayilmasi basarili bir sonuç göstermektedir. Bebek konsantre yumusaticisindaki koku performansini degerlendirmek üzere; iso e super içeren ve iso e superin yerine ikame edilecegi kompozisyonu içeren olmak üzere toplam 2 esans hazirlanmaktadir. Tablo 4. Bebek Yumusaticisi Esans Bilesenleri ve Oranlari Bebek Yumusatici Bebek Yumusatici Esans Bilesenleri Esans Bilesenleri Acetophenone 0,130 Eucalyptol natural 0,040 Aldehyde C- 12 1,100 Fruitate 0,300 Amyl salicylate 10,000 Ionone beta 4,000 Methyl napthyl Anisaldehyde 0,800 1,200 ketone beta Bicyclononalactone 1,000 Methyl diantilis 0,700 Methyl dihydro Borneol 0,300 _ 10,000 Jasmonate Citronellyl acetate 0,500 Nerolin yara yara 0,050 Patchouli oil Cyclacet 1,000 _ 1,500 Sulawesi Cyclal C 0,700 Phenyl ethyl alcohol 8,000 Cyclamen aldehyde 0,500 PTBCH acetate 5,000 Cyclaprop 4,000 Rosalin 5,000 Damascone delta 0,150 Strallyl acetate 0,900 Dipropylene glycol 11,230 Tetrahydro geraniol 2,000 Ethyl vanillin 0,600 Thymol 0,100 Verdox 14,000 Toplam 100,00 Tablo 4,de bilesenleri verilen esans formülasyonuna göre, birinde %10 konsantrasyonda iso e super, digerinde %10 konsantrasyonda iso e super yerine %10 konsantrasyonda alerj en olmayan bulus konusu kompozisyonu içeren iki ayri esans formülasyonu hazirlanarak standart bir bebek konsantre yumusatici bazina %1,5 konsantrasyonunda ayri ayri uygulanmistir. Esanslar ile hazirlanan iki bebek konsantre yumusaticisinin performans testi uygulamasinda; ayni marka ve ayni model iki ayri çamasir makinesinin çamasir haznesine agirliklari yaklasik ayni olan farkli doku ve malzemedeki esit boyutlardaki kumaslardan ayni adette konulmustur. Her iki esans ile hazirlanan bebek konsantre yumusaticilarindan 35 gr tartilmis ve tartilan esanslar çamasir makinesi haznesinin içindeki kumaslarin üzerine dökülmüstür. Daha sonra, 40°C ve 1000 rpm deVirde 22 dk boyunca durulama islemi yapilmistir. Söz konusu islemler tamamlandiktan sonra kumaslar makinelerden çikartilmistir. performans testleri açisindan degerlendirilmesi parfümör ve esans analistlerinden olusan 10 kisilik bir panel ekibiyle yapilmistir. Öncelikle, iso e super içeren esans ile yapilmis bebek yumusaticisi referans alinarak iso e super yerine alerj en olmayan ikame kompozisyonu içeren ayni esans ile yapilmis iki ayri bebek yumusaticisi siseleri es zamanli olarak koklanmistir. Her iki ürün arasindaki karsilastirma koku profili ve koku gücü olmak üzere iki ayri kriter göz önünde bulundurularak yapilmistir. Daha sonra, çamasir makinesinde yapilan yikama isleminden sonra her iki ürünün kokusunun islak kumaslardaki kaliciligi koku profili ve koku gücü olmak üzere iki ayri kriter göz önünde bulundurularak degerlendirilmistir. kisilik panel ekibi 1 ile 5 arasindaki bir puanlama sistemiyle iso e super içeren esansin kullanildigi bebek konsantre yumusaticisini referans alarak alerjen olmayan ikame kompozisyonu içeren esansin kullanildigi bebek konsantre yumusaticisi ile karsilastirmistir. Söz konusu degerlendirme sonuçlari Tablo 5,te verilmektedir. Tablo 5. Bebek Yumusatici Puanlama Sistemi Degerlendirme Sonuçlari Kokunun bebek konsantre Kokunun bebek konsantre yumusaticisi ile kumaslarin Esans yumusaticisindaki yayilimi yikanmasindan sonra islak kumastaki yayilimi ve kaliciligi Begeni Koku gücü Begeni Koku gücü Alerj en olmayan ikame kompozisyonu içeren esans 4.4 4.2 4.2 4 Tablo 5,te bahsedildigi üzere ilk olarak, iso e super içeren ve iso e super yerine ayni konsantrasyonda ikame edilen bulus konusu kompozisyonu içeren esanslar ile yapilan yumusaticilar öncelikle siseden koklanarak duyusal olarak analiz edilmistir. 1 ile 5 arasindaki puanlama sistemine göre testte kokunun begeni ve koku gücü açisindan her biri 4.9 puan almistir. Ikame kompozisyon içeren ayni esans ile yapilan yumusatici kokunun begeni kriteri açisindan 4.4 puan ve koku gücü açisindan ise 4.2 puan almistir. Ikinci duyusal analizde ise iso e super içeren ve iso e super yerine ikame bulus konusu kompozisyon içeren ayni esans ile yapilmis yumusaticilarin iki ayri çamasir makinesinde ayni yikama programi ile esit miktarda ayni malzemedeki kumaslarin yikanmasi sonucunda kumaslarda kalan kokunun begenisi ve koku gücü degerlendirilmistir. Yikamadan sonra iso e super içeren esans ile yapilmis yumusatici begeni olarak 4.7 puan, koku gücü olarak 4.7 puan ortalamasi almistir. Iso e super yerine ikame kompozisyon içeren ayni esans ile yapilmis yumusaticinin yikama sonucuna göre ise testte begeni açisindan 4.2 puan ve koku gücü bakimindan 4 puan almistir. Bir önceki analiz sonuçlarinda belirtildigi gibi duyusal analizlerde kabul edilebilir puan alt siniri en az 3 puan olmasi gerekmektedir. Yukarida belirtilen sonuçlarin 3,ten fazla ve iso e super içeren esansa oldukça yakin degerler almasi ile basarili bir performans sagladigi anlasilmaktadir. Bebek siVi deterjani koku performansini degerlendirmek üzere; Tablo 6,de bilesenleri verilen esans formülasyonuna göre, birinde %10 konsantrasyonda iso e super içeren ve digerinde %10 konsantrasyonda iso e super yerine %10 konsantrasyonda alerj en olmayan bulus konusu ikame kompozisyonu içeren iki ayri esans hazirlanmistir. Tablo 6. Bebek Sivi Deterjani Esans Bilesenleri ve Oranlari Bebek Sivi Deterj ani Esans Bebek Sivi Deterj ani Esans Bilesenleri Bilesenleri Anisaldehyde 0,150 Helional 0,150 Bacdanol 0,150 Iso E super 9,000 Benzaldehyde 0,020 Ionone alpha 0,600 Bois ambrene forte 1,200 Ionone beta 2,000 Cedryl methyl ether 1 , 100 Linalyl acetate 0,700 Citronellyl nitrile 0,400 Methyl anthranilate 0,200 Cyclacet 3,500 Methyl dihydro j asmonate 8,000 Cyclaprop 1,000 Phenyl ethyl alcohol 0,150 Dihydro ionone beta 0,600 PTBCH acetate 15,000 Dihydro myrcenol 7,000 Pyranol 0,800 Dipropylene glycol 43,060 Strallyl acetate 0,400 Ethyl-2-methyl pentanoate 0,150 Tetrahydro geraniol 0,300 Ethyl benzoate 0,250 Tetrahydro linalool 1,000 Ethyl linalool 0,500 Tonalid 0,450 Eucalpytol natural 0,080 Trivertal 0,05 0 Floralozone 0,900 Toplam 100,000 Hazirlanan iki esans standart bir bebek sivi deterjani baZina %1 konsantrasyonunda ayri ayri uygulanmistir. Hazirlanan iki esansin performans testi uygulamasinda; ayni marka ve model iki ayri çamasir makinesinin çamasir haznesine agirliklari yaklasik ayni olan farkli doku ve malzemedeki esit boyutlardaki kumaslardan ayni adette konulmustur. Her iki esans ile hazirlanan bebek sivi deterjan ürünlerinden 60 gr tartilmakta ve tartilan esanslar çamasir makinesinin deterjan haznesine dökülmüstür. Daha sonra, 40°C ve 1000 rpm devirde 60 dk boyunca yikama islemi yapilmistir. Islem tamamlandiktan sonra kumaslar makinelerden çikartilmistir. esansin duyusal ve performans testleri açisindan degerlendirilmesi parfümör ve esans analistlerinden olusan 10 kisilik bir panel ekibiyle yapilmistir. Yukaridaki islemlerden sonra iso e super içeren esans referans alinarak iso e super yerine alerjen olmayan ikame kompozisyonu içeren ayni esans ile asagidaki sekilde karsilastirilmistir. alerjen olmayan ikame kompozisyonu içeren ayni esans ile yapilmis bebek sivi deterjani siselerden es zamanli olarak koklanmistir. Her iki ürün arasindaki karsilastirma koku profili ve koku gücü olmak üzere iki ayri kriter göz önünde bulundurularak yapilmistir. Çamasir makinesinde yapilan yikama isleminden sonra her iki ürünün kokusunun islak kumaslardaki kaliciligi koku profili ve koku gücü olmak üzere iki ayri kriter göz önünde bulundurularak yapilmistir. kisilik panel ekibi 1 ile 5 arasindaki bir puanlama sistemiyle iso e super içeren esansin kullanildigi bebek sivi deterj anini referans alarak alerjen olmayan ikame kompozisyonu içeren esansin kullanildigi bebek sivi deterjani ile karsilastirmistir. Yukaridaki maddelerde belirtilen koku degerlendirme kriterlerine göre 10 kisilik panel ekibinin degerlendirme sonuçlari Tablo 7,de verilmektedir. Hem sivi deterj andaki koku yayilimi hem de sivi deterjan ile kumaslarin yikanmasindan sonra islak kumastaki koku yayilimi ve kaliciligi açisindan koku profilinin begenisi ve gücü açisindan ayri ayri puan verilmistir. Tablo 7. Bebek Sivi Deterjan Puanlama Sistemi Degerlendirme Sonuçlari Kokunun siVi deterjan ile Kokunun siVi deterj andaki kumaslarin yikanmasindan sonra Esans yayilimi islak kumastaki yayilimi ve kaliciligi Begeni Koku gücü Begeni Koku gücü Alerjen olmayan ikame Tablo 7,de göründügü üzere ilk olarak, iso e super içeren ve iso e super yerine ayni konsantrasyonda ikame bulus konusu kompozisyonu içeren esanslar ile yapilan siVi deterj anlar öncelikle siseden koklanarak duyusal olarak analiz edilmistir. 1 ile 5 arasindaki puanlama sistemine göre testte kokunun begeni ve koku gücü açisindan her biri 4.79 puan almistir. Ikame kompozisyon içeren ayni esans ile yapilan siVi deterjan ise kokunun begeni kriteri açisindan 4.47 puan ve koku gücü açisindan ise 4.21 puan almistir. Ikinci duyusal analizde ise iso e super içeren ve iso e super yerine ikame bulus konusu kompozisyon içeren ayni esans ile yapilmis deterj anlarin iki ayri çamasir makinesinde ayni yikama programi ile esit miktarda ayni malzemedeki kumaslarin yikanmasi sonucunda kumaslarda kalan kokunun begenisi ve koku gücü degerlendirilmistir. Yikamadan sonra iso e super içeren esans ile yapilmis yumusatici begeni ve koku gücü olarak 4.83 puan ortalamasi alinmistir. Iso e super yerine ikame kompozisyon içeren ayni esans ile yapilmis deterjanin yikama sonucuna göre ise panel testte begeni açisindan 4.44 puan ve koku gücü bakimindan 4.06 puan almistir. Daha önce belirtildigi üzere duyusal analizlerde kabul edilebilir puan alt siniri en az 3 puan olmasi gerekmektedir. Yukarida belirtilen sonuçlarin 3,ten fazla ve iso e super içeren esansa oldukça yakin degerler almasi ile basarili bir performans sagladigi anlasilmaktadir. bazi fiziksel analizlerinin degerlendirilmesinde; iso e super ve alerj en olmayan ikame kompozisyonlari içeren bebek sampuani, bebek konsantre yumusaticisi ve bebek siVi deterj ani kategorisindeki esanslarin 20°Cadeki yogunluklari ölçülmüstür. Söz konusu yogunluk sonuçlari Tablo 8 , de verilmektedir. Tablo 8. Yogunluk Deney Sonuçlari Yogunluk (g/cm3) Bebek siVi Bebek sampuani Bebek konsantre _ _ Esans testi için kullanilan yumusaticisi testi _ _ için kullanilan esans için kullanilan esans Alerj en olmayan ikame kompozisyonu içeren esans yumusaticisi ve bebek siVi deterjani kategorisindeki esanslarin 20°Cadeki kirilma indisleri ölçülmüs olup, sonuçlar Tablo 9,da verilmektedir. Tablo 9. Kirilma Indisi Deney Sonuçlari Kirilma indisi Bebek siVi Bebek sampuani testi _ deterJ ani testi Esans _ _ yumusaticisi testi _ _ için kullanilan esans Alerj en olmayan ikame kompozisyonu içeren esansIso e super ve alerj en olmayan ikame kompozisyonlari içeren bebek sampuani, bebek konsantre yumusaticisi ve bebek siVi deterjani kategorisindeki esanslarin 20°C,deki parlama noktalari ölçülmüs olup, sonuçlar Tablo 10,da verilmektedir.10 Tablo 10. Parlama Noktalari Deney Sonuçlari Parlama noktasi (OC) Bebek sampuani Bebek konsantre Bebek siVi Esans testi için kullanilan yumusaticisi testi deterj ani testi için esans için kullanilan esans kullanilan esans Alerj en olmayan ikame . . 106 104 95 kompozisyonu içeren esans yogunluk ve kirilma indislerindeki degisimler, yukarida verilen tablolarda da görülügü üzere genel olarak ±1 araliginda bir sapmayla gerçeklesmektedir. Bu esanslarin bitmis ürünler olan bebek sampuaninda %1, bebek yumusaticisinda %1,5 ve siVi deterj anda %1 konsantrasyonunda kullanildiginda bitmis ürünün yogunluk degisimine etkisi %001 civarlarinda olmaktadir, bu da çok küçük bir sapmadir. Bu sebeple ikame kompozisyonun bitmis ürünlerde kayda deger bir yogunluk ve kirilma indisi degeri degistirdigi söylenemeZ. Ayni durum parlama noktasi için de geçerlidir. bebek sampuani, bebek konsantre yumusaticisi ve bebek siVi deterj anlarinin ViZkositeleri esans içermeyen bebek sampuani, bebek konsantre yumusaticisi ve bebek siVi deterjani bazlari ile karsilastirmali olarak ölçülmüstür. Ölçümler bir reometre cihazi ile centripoise cinsinden yapilmis olup, her bir kategori için sonuçlar Tablo 11, 12 ve 13,te verilmektedir. Tablo 11. Bebek Sampuani Viskozite Ölçüm Sonuçlari Esans Viskozite (cp) Bebek sampuani baZi 5900 sampuani 9200 esansin kullanildigi bebek sampuani Tablo 12. Bebek Konsantre Yumusaticisi Viskozite Ölçüm Sonuçlari Esans Viskozite (cp) Bebek konsantre yumusaticisi bazi 300 konsantre yumusaticisi 460 esansin kullanildigi bebek konsantre yumusaticisi 405 Tablo 13. Bebek Sivi Deterjani Viskozite Ölçüm Sonuçlari Esans Viskozite (cp) Bebek siVi deterjani bazi 330 deterjani 785 esansin kullanildigi bebek siVi deterjani 650 Esansin uygulandigi son üründe Viskozite artisi yapmasi normal bir durumdur. Örnegin bebek sampuani bazinin esans eklenmeden önceki Viskozitesi 5900 cp olup %1 konsantrasyonda iso e super içeren esans eklenmesinden sonra Viskozitesinin 9200 cp degerine çiktigi görülmektedir. %10 konsantrasyonda iso e super yerine %10 konsantrasyonda alerj en olmayan bulus konusu kompozisyonu içeren esansin %1 konsantrasyonda kullanilmasi ile hazirlanmis bebek sampuaninin Viskozite degeri 7400 cp olarak ölçülmüstür. Bu durumda da Viskozite 5900 cp,den 7400 Cpaye çikmistir. Buradaki önemli nokta bebek sampuaninin Viskozitesinin 5 900 cp degerinden daha düsük bir degerlere düsmemesi gerektigidir. Çünkü bazi esans bilesenleri Viskoziteyi düsürücü yönde de etki yapabilmektedir. Böyle bir durumda da bebek sampuani ürününün akiskanligi artacak ve ürünün formu bozulacaktir. Bulus konusu Iso e super yerine gelistirilen alerj en olmayan ikame kompozisyon böyle bir sorunu neden olmayarak uygulandigi ürünün Viskozitesinin olmasi gereken minimum degerin üzerinde muhafaza edebilmektedir. Bu da iso e super yerine gelistirilen alerjen olmayan ikame kompozisyonun etkin bir özeligidir. Bu tarifnamede açiklanan herhangi bir özellik (ekteki istemler, özet, çizimler dâhil), aksi açikça belirtilmedikçe, esdeger veya benzer amaçlara sahip olabilecek diger alternatif özelliklerle degistirilebilir. Yani, aksi açikça belirtilmedikçe, her özellik, bir dizi esdeger veya benzer özelligin yalnizca bir ömegidir. Yukaridaki düzenlemeler, yalnizca mevcut bulusun teknik konseptini ve özelliklerini açiklamayi amaçlamaktadir ve mevcut bulusun amaci, teknikte uzman kisilerin mevcut bulusun içerigini anlamasini ve mevcut bulusu uygulamasini saglamaktir ve mevcut bulusun kapsami bununla sinirli degildir. Esdeger degisiklikler veya bulusun ruhuna uygun olarak yapilan modifikasyonlarin bulus kapsamina alinmasi amaçlanmaktadir. Bulusun Sanavive Uygulanmasi Bulus, Avrupa Birligi nezdinde yeni alerjen esans hammaddesi olarak eklenen 1- alternatif olarak gelistirilen alerjen içermeyen bir koku kompozisyonu yapilanmasi ile ilgili olup, sanayiye uygulanabilir niteliktedir. Bulus yukaridaki örnek uygulamalar ile sinirli olmayip, teknikte uzman bir kisi kolaylikla bulusun farkli diger uygulamalarini ortaya koyabilir. Bunlar bulusun istemler ile talep edilen koruma kapsaminda degerlendirilmelidir. TR TR TR TR TR DESCRIPTION FORMATION OF AN ALLERGEN-FREE FRAGRANCE COMPOSITION Technical Field The invention is related to the formation of an allergen-free fragrance composition developed as an alternative to 1- which is added as a new allergen essence raw material in the European Union. State of the Art The new allergen essence raw material naphthyl)ethane-1-one (Iso e super) compound is also added to the 26 allergen essence raw materials used in cosmetic products determined in the regulation numbered 1223/2009 of the European Union Parliament. The use of the said compound in the cosmetic field and especially in personal care products produced for people with sensitive skin, including baby products, is restricted. Thus, new allergen-free compositions need to be developed in the said areas. The compounds contained in the compositions in the state of the art, especially in products such as baby shampoo, baby liquid detergent and baby softener, are dissolved with hot water during washing and removed from the environment. This reduces the permanent odor feature in these applications. In the current technique, according to the updated European Union cosmetics regulation, hypoallergenic products are produced in cosmetic products (shampoo, soap and indirectly, since there is skin sensitivity, and also for most products related to babies). Hypoallergenic products should also not contain allergenic content or should be below the limits specified in this regulation. The maximum amount for each allergen in products such as shampoo and soap that are rinsed with water is 100 ppm. If it is over 100 ppm, the allergenic substance must be stated on the product label. Similarly, in products that do not rinse (perfume, baby oil, baby lotion, wet wipes etc.), the maximum amount for each allergen substance is 10 ppm. If it is above 10 ppm, it must be stated on the product label in the same way. Some product manufacturers want the allergen content to be 0 ppm regardless of the concentrations of 100 ppm and 10 ppm. For this reason, it is necessary to develop new compositions that are non-allergenic and have permanent odor properties. It is related to compositions in the field of perfume oils with an improved odor profile containing at least one odor different from carvomenton and at least one cosmetically acceptable carrier and to the synthesis and application of new compounds with desired odor properties. Brief Description of the Invention The present invention is aimed to eliminate the above-mentioned disadvantages and to provide new advantages to the relevant technical field; It is related to the construction of an allergen-free fragrance composition developed as an alternative to the new allergen essence raw material compound in the European Union. The invention provides a new composition development for non-allergenic essence formulations. In addition, allergen-free products are being developed in accordance with European Union Standards. With the invention, a non-allergenic alternative composition is obtained in cosmetic products such as baby shampoo where allergenic components are not desired or restricted, and also in other product groups such as baby detergent and baby softener, which are not cosmetic products and will be used for babies. The composition in question is proven to remain in the fabric longer by testing the fabric washing processes and sensory analyses in products such as baby shampoo, baby liquid detergent and baby softener. Thus, a persistent and non-allergenic fragrance composition is achieved by the invention. Detailed Description of the Invention Exemplary embodiments are described in more detail below with reference to the accompanying descriptions. However, embodiments may be rendered in different forms and should not be construed as limited to the embodiments set forth herein. Instead, these exemplary embodiments are provided for the completeness and full conveyance of the scope of this disclosure to those skilled in the art. The terminology used in this specification is intended to be used only for the purpose of describing a particular exemplary embodiment and is not intended to be limiting. As used herein, the context of "an", "at least", "preferably" and "and/or" includes the plural forms unless expressly indicated otherwise. The invention is related to the structuring of an allergen-free fragrance composition developed as an alternative to the new allergen added essence raw material in the European Union; l-(2-theityl-butylcyclohexyl)oxybutan-2-ol (Ambercore), 3A,6,6,9A- Tetramethyldodecahydronaphtho [2, 1 -B]furan (AmbrofiX), (1R,ZS,5R,8S)-4,4,8-Trimethyltricyclo(6.3.1.02,5)-dodecan-1-yl acetate (Caryophylene aceta te), 3-(3-hydroxypropoxy)propan-1-ol (Dipropylene glycol), l-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-pentanone, reaction products with 2-propyn-1-ol (Grisalva), (4-tert-butylcyclohexyl) acetate (PTBCH acetate) and vetiveria zizanioides root extract acetate (Vetiver aceta). you eX-haiti). The fragrance composition which is the subject of the invention; - 0.4-2% by weight l-(2-tert-butylcyclohexyl)oxybutan-2-ol, - 0.1-0.7% by weight 3A,6,6,9A-Tetramethyldodecahydronaphtho[2,1-B]furan, - 85-95% by weight 3-(3-hydroxypropoxy)propan-1-ol, - 0% by weight It contains 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-pentanone, reaction products with 2-propyn-1-ol in the ratio of 5-2, - (4-tert-butylcyclohexyl) acetate in the ratio of 0.03-0.5% by weight, - Vetiveria zizanioides root extract acetate in the ratio of 0.1-0.7% by weight. In one embodiment of the invention, the composition structuring ratios in question are given in Table 1; Table 1. Composition Ingredients Trade name Name Number Ratio Amber core Amber butanol AmbrofiX 3A,6,6,9A-Tetramethyldodecahydronaphtho[2, 1 -B]furan Ambroxide (1R,2S,5R,8S)-4,4,8- Caryophyllene _ _ _ _ _ Dipropylene 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3 - pentanone, 2-propyn-1-ol reaction products With Grisalva Amber Furan (3 -Pentanone, 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-, reaction products With 2- propyn-1-ol) PTBCH acetate VeiIeneX Cyclohexyl Vetiver acetate _ _ _ _ _ _ As also indicated in Table 1 In one embodiment of the composition according to the invention, the content ratios are as follows; - 0.8% by weight of 1-(2-tert-butylcyclohexyl)oxybutan-2-ol, - 0.35% by weight of 3A,6,6,9A-Tetramethyldodecahydronaphtho[2, l -B]furan octahydro-1H benzo[e] [l]benzofuran, - 92.85% by weight of 3-(3-hydroxy) propoxy)propan-l-ol, - 1.5% by weight of 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-pentanone, reaction products with 2-propyn-l-ol, - 0.3% by weight of (4-tert-butylcyclohexyl) acetate, - 0.2% by weight of vetiveria Zizanioides root extract acetate . In order to provide permanence, molecules with log p = 3 and above are generally suitable, but preferably molecules with log p = 4 and above provide even better odor permanence. For this reason, raw materials were determined and tested considering these criteria in the substitute composition of the invention. Amber core (1-(2-tert- butylcyclohexyl)oxybutan-2-ol) is used in the invention to provide a soft ambery odor profile. In addition, since the log p value is approximately 5.65, the odor permanence in the fabric after washing is comparable to iso e super. AmbrofiX (3A,6,6,9A- Tetramethyldodecahydronaphtho [2,1-B]furan) is used in the invention to provide the ambergris odor profile. In addition, since the log p value is approximately 5.411, the odor retention in the fabric after washing is observed to be good. In the invention, caryophylene acetate ((1R,ZS,5R,SS)- 4,4,8-Trimethyltricyclo(6.3.1.02,5)-dodecan-1-yl acetate) is used to provide cedarwood and woody odor profile. In addition, since the log p value is approximately 5.36, it is provided to remain in the fabric longer since it is less soluble in water after washing. In the invention, dipropylene glycol (3-(3-hydroxypropoxy)propan-1-ol) is used as a solvent and is odorless. Product dilution and cost savings are provided with the said compound. In the invention, grisalva (1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-pentanone, reaction products with 2-propyn-1-ol) is used to provide ambergris and leathery odor profile. In the invention, PTBCH acetate ((4-teth-butylcyclohexyl) acetate) is used to provide floral and at the same time woody, soft and smooth odor profile. In addition, since the log p value is 4.23, although it is slightly lower than the log p value of iso e super, which is 5.65, it is less soluble in water after washing and its permanence is obtained. In the invention, vetiveria zizanioides root extract acetate is used to provide dry woody odor profile. Some examples of the trade names of the compounds mentioned in the invention are given. The names in question can be increased, decreased or other names can be used according to the literature. The invention is not limited to the commercial names mentioned in the specification in practice. The composition developed with the invention is used in the fields of essence and cosmetics. In addition, in baby care products; for example, baby detergent, baby softener, baby wet wipes, baby shampoo, baby soap and all similar products, all allergen-free personal or non-personal cleaning and care products for people with sensitive skin types, small child care products and wipes, wet or dry wipes, detergents, softener, shampoo and soap are used in the cleaning and care sector, which is included in all allergen-free cosmetics sector usage. The composition in question is obtained as a result of many trials. In each composition trial, the composition in question was compared odorously with the Iso e super compound. After the experimental stages in question, the above-mentioned contents and ratios emerged. 3 methods were preferred. As the first method, the odorous comparison of the iso e super with the alternative composition in oil form is interpreted according to perfumery terminology. As the second method, the scents of the essence formulations containing and not containing iso e super (containing the alternative composition developed instead) are compared after being applied to baby shampoo, baby softener and baby liquid detergent. As the last method, the scent persistences are compared by performing washing tests after the developed essences are applied to baby shampoo, baby liquid detergent and baby softener. Here, when baby shampoo is evaluated, water is put into a beaker at 35-40°C, a certain amount of shampoo is added, homogenized and the odor spread from hot water is compared; then a certain amount of real hair is put into this water and the shampoo water is absorbed by the hair; then it is removed from the water and the odor persistence in the hair is evaluated. For liquid detergent and softener, first the essence is turned into liquid detergent and softener and then bottled; then a simultaneous washing test is performed in washing machines with this liquid detergent and softener, including a certain number of different textile fabrics. After the washing test in question, the odor persistence in wet fabric is compared. The essences contained in the composition in question have been evaluated in 3 separate categories as baby shampoo, baby liquid detergent and baby concentrated softener. Instead of the compound called iso e super in the essence in each product category, the non-allergenic iso e super alternative composition has been used at the same concentration. The essence formulation contents and ratios in which the composition in question in question which is substituted for iso e super and iso e super in question in the 3 separate consumer product categories will be comparatively evaluated are given in Table 2, Table In order to evaluate the odor performance in baby shampoo; According to the essence formulation whose components are given in Table 2, two separate essences were prepared, one containing 10% concentration of iso e super and the other containing 10% concentration of the non-allergenic substitute composition in question instead of iso e super. Table 2. Baby Shampoo Essence Components and Ratios Baby Shampoo Essence Components Ratio (%) Baby Shampoo Essence Components Ratio (%) Anisaldehyde 0,700 Iso E super 10,000 Anisyl acetate 0,200 Indolarome 0,050 Benzaldehyde 0,150 Ionone alpha 0,100 Bicyclononlactone 0.5 00 Jessemal 0.100 Cis-3-hexenol 0.050 Lemonile 0.100 Cis-3-hexenyl salicylate 4.000 Linalyl acetate 3.200 Cumin oil 1% DPG, 0.400 Mayol 1.700 Cyclamen aldehyde 0.650 Methyl cyclopentenolone 1% DPG 0.40 0 Dihydro ionone beta 0.300 Methyl dihydro jasmonate 10.000 Dihydro myrcenol 3.000 Nerolione 0.030 Dimethyl anthranilate 0.05 0 Piperonyl acetone 0.200 Dimethyl benzyl carbinyl acetate 0.300 Pyranol 1.500 Dipropylene glycol 49.510 Sandalore 0.5 00 Do decalactone delta 0.100 Strallyl acetate 0.100 Ebanol 0.300 StyraX substitute 0.150 Ethyl maltol 0.050 Tetrahydro geraniol 0.800 Ethyl vanillin 1.500 Tetrahydro linalool 1.300 Gamma decalactone 0.100 Trivertal 0.030 Geranyl ace tate 0.700 Verdox 0.200 Helional 0.800 Total 100,000 Two separate essences were applied to a standard perfume-free baby shampoo base at a concentration of 1%. In the performance test application of the two essences prepared; 2 g of baby shampoo prepared with essence containing iso e super was weighed into one of the two 250 mL beakers; 2 g of baby shampoo prepared with essence containing non-allergenic substitute composition instead of iso e super was weighed into the other beaker on a precision scale. Hot water was added to both beakers so that the temperature would be approximately 35°C and the mixture was completed to 250 mL. The water in both beakers was mixed with a glass rod to ensure that the mixture became homogeneous. An equal amount of real hair was added to the water in both beakers and the hair was kept in hot water for approximately 30 seconds and removed from the beakers. The evaluation in terms of performance tests was made by a panel team of 10 people consisting of perfumers and essence analysts. After the above-mentioned processes, the essence containing iso e super was taken as a reference and compared with the essence containing the non-allergenic substitute composition in question as follows; For the spread of the scent in the shampoo; Baby shampoos in which essences containing iso e super and non-allergenic substitute composition were used were smelled from a distance of approximately 2 cm from the bottle and the odor profile and odor strength were compared. For the spread of the scent in the hair washed with the shampoo; The hair washed in hot water prepared using baby shampoos containing essences containing iso e super and non-allergenic substitute composition was smelled while wet from a distance of approximately 2 cm to determine the odor profile and the spread of the odor in the shampoo dissolved in hot water; The hot water in both 250 mL beakers prepared using baby shampoos containing essences containing iso e super and non-allergenic substitute composition were smelled to compare in terms of odor profile and odor strength. A panel team of 3 people compared the baby shampoo containing essence containing iso e super with the baby shampoo containing essence containing non-allergenic substitute composition using a scoring system between 1 and 5, taking the baby shampoo containing essence containing iso e super as reference. According to the above mentioned odor evaluation criteria, the evaluation results of the 10-person panel team are given in Table 3. Table 3. Baby Shampoo Scoring System Evaluation Results Smell Smell Hot Essence in shampoo in shampoo containing non-allergenic substitute composition The acceptable lower limit of the score in the sensory analyzes performed should be at least 3 points. As seen in Table 3, the essence containing the composition in question increased to 4.306 points in the spread of the scent in the shampoo, and a close score was obtained compared to the essence containing iso e super. In the essence spreads of the scent in the hair washed with the shampoo, a performance above 3 is achieved, and sufficient permanence in the hair is achieved. In addition, the spread of the scent in hot water soluble shampoo, for example, means the spread of the scent as a result of contact with the shower water when using shampoo during showering. The invention shows a successful result in the spread of the scent in hot water by showing a performance above 3, as in the previous parameter. In order to evaluate the scent performance in the baby concentrated softener; a total of 2 essences are prepared, including iso e super and the composition in which iso e super will be replaced. Table 4. Baby Softener Essence Components and Ratios Baby Softener Baby Softener Essence Components Essence Components Acetophenone 0.130 Eucalyptol natural 0.040 Aldehyde C- 12 1.100 Fruitate 0.300 Amyl salicylate 10.000 Ionone beta 4.000 Methyl napthyl Anisaldehyde 0 .800 1.200 ketone beta Bicyclononalactone 1.000 Methyl diantilis 0.700 Methyl dihydro Borneol 0.300 _ 10.000 Jasmonate Citronellyl acetate 0.500 Nerolin wound wound 0.050 Patchouli oil Cyclacet 1.000 _ 1.500 Sulawesi Cyclal C 0.7 00 Phenyl ethyl alcohol 8.000 Cyclamen aldehyde 0.500 PTBCH acetate 5.000 Cyclaprop 4.000 Rosalin 5.000 Damascone delta 0.150 Strallyl acetate 0.900 Dipropylene glycol 11.230 Tetrahydro geraniol 2.000 Ethyl vanillin 0.600 Thymol 0.100 Verdox 14.000 Total 100.00 According to the essence formulation whose components are given in Table 4, two separate essence formulations were prepared, one containing 10% concentration of iso e super, the other containing 10% concentration of the non-allergenic composition in question instead of iso e super, and were applied separately at a concentration of 1.5% on a standard baby concentrated softener base. In the performance test application of two baby concentrated softeners prepared with essences; the same number of fabrics of different textures and materials, with approximately the same weight, were placed in the washing machine chamber of two separate washing machines of the same brand and model. 35 grams of baby concentrated softeners prepared with both essences were weighed and the weighed essences were poured onto the fabrics in the washing machine chamber. Then, the rinsing process was carried out for 22 minutes at 40°C and 1000 rpm. After the said processes were completed, the fabrics were removed from the machines. The evaluation in terms of performance tests was carried out by a panel team of 10 people consisting of perfumers and essence analysts. First, two separate baby softener bottles made with the same essence containing non-allergenic substitute composition instead of iso e super were smelled simultaneously by taking the baby softener made with essence containing iso e super as a reference. The comparison between the two products was made by considering two separate criteria, namely odor profile and odor strength. Then, the persistence of the odor of both products on wet fabrics after washing in the washing machine was evaluated by considering two separate criteria, namely odor profile and odor strength. The panel team of 10 people compared the baby concentrated softener using essence containing iso e super as a reference with the baby concentrated softener using essence containing non-allergenic substitute composition using a scoring system between 1 and 5. The results of the evaluation are given in Table 5. Table 5. Baby Softener Scoring System Evaluation Results The spread of scent in the baby concentrated scent in the fabrics with the essence softener and the spread and permanence on wet fabric after washing Like Odor strength Like Odor strength Essence containing non-allergenic substitute composition 4.4 4.2 4.2 4 As mentioned in Table 5, firstly, the softeners made with essences containing iso e super and the composition in question substituted in the same concentration instead of iso e super were firstly smelled from the bottle and analyzed sensorily. According to the scoring system between 1 and 5, each of them received 4.9 points in terms of odor liking and odor strength in the test. The softener made with the same essence containing substitute composition received 4.4 points in terms of odor liking criterion and 4.2 points in terms of odor strength. In the second sensory analysis, the liking and odor strength of the remaining odor on the fabrics were evaluated as a result of washing the fabrics of the fabrics with the same amount of the same material with the same washing program in two separate washing machines with the softeners made with the same essence containing iso e super and the composition in question as a substitute for iso e super. After washing, the softener made with the essence containing iso e super received 4.7 points in liking and 4.7 points in odor strength. According to the washing result of the softener made with the same essence containing the composition as a substitute for iso e super, it received 4.2 points in liking and 4 points in odor strength in the test. As stated in the previous analysis results, the acceptable score lower limit in sensory analyses should be at least 3 points. It is understood that a successful performance is provided by the above-mentioned results having values more than 3 and very close to the essence containing iso e super. In order to evaluate the odor performance of the baby liquid detergent; two separate essences were prepared, one containing 10% concentration of iso e super and the other containing 10% concentration of the non-allergenic substitute composition of the invention instead of 10% concentration of iso e super, according to the essence formulation whose components are given in Table 6. Table 6. Baby Liquid Detergent Essence Components and Proportions Baby Liquid Detergent Essence Baby Liquid Detergent Essence Components Components Anisaldehyde 0.150 Helional 0.150 Bacdanol 0.150 Iso E super 9.000 Benzaldehyde 0.020 Ionone alpha 0.600 Bois ambrene forte 1.200 Ionone beta 2.000 Cedryl methyl ether 1.100 Linalyl acetate 0.700 Citronellyl nitrile 0.400 Methyl anthranilate 0.200 Cyclacet 3.500 Methyl dihydro j asmonate 8.000 Cyclaprop 1.000 Phenyl ethyl alcohol 0.150 Dihydro ionone beta 0.600 PTBCH acetate 15,000 Dihydro myrcenol 7,000 Pyranol 0.800 Dipropylene glycol 43,060 Strallyl acetate 0.400 Ethyl-2-methyl pentanoate 0.150 Tetrahydro geraniol 0.300 Ethyl benzoate 0.250 Tetrahydro linalool 1.000 Ethyl linalool 0.500 Tonalid 0.450 Eucalpytol natural 0.080 Trivertal 0.05 0 Floralozone 0.900 Total 100,000 The two prepared essences were applied separately at a concentration of 1% based on a standard baby liquid detergent. In the performance test application of the two prepared essences; The same number of fabrics of different textures and materials, of approximately the same weight, and of equal sizes were placed in the washing chamber of two separate washing machines of the same brand and model. 60 grams of baby liquid detergent products prepared with both essences were weighed and the weighed essences were poured into the detergent chamber of the washing machine. Then, the washing process was carried out for 60 minutes at 40°C and 1000 rpm. After the process was completed, the fabrics were removed from the machines. The evaluation of the essence in terms of sensory and performance tests was carried out by a panel of 10 people consisting of perfumers and essence analysts. After the above processes, the essence containing iso e super was taken as a reference and compared with the same essence containing non-allergenic substitute composition instead of iso e super as follows. The baby liquid detergent made with the same essence containing non-allergenic substitute composition was simultaneously smelled from the bottles. The comparison between both products was made by considering two separate criteria, namely odor profile and odor strength. The permanence of the odor of both products on wet fabrics after the washing process in the washing machine was made by considering two separate criteria, namely odor profile and odor strength. The panel team of 3 people compared the baby liquid detergent using the essence containing iso e super with a scoring system between 1 and 5, taking the baby liquid detergent using the essence containing non-allergenic substitute composition as a reference. The evaluation results of the 10-person panel team according to the odor evaluation criteria specified in the above items are given in Table 7. Separate scores were given in terms of liking and strength of the odor profile in terms of both odor spread in liquid detergent and odor spread and persistence in wet fabric after washing the fabrics with liquid detergent. Table 7. Baby Liquid Detergent Scoring System Evaluation Results Fragrance spread after washing the fabrics with liquid detergent Fragrance spread in wet fabric and persistence Like Odor strength Like Odor strength Non-allergenic substitution As seen in Table 7, firstly, liquid detergents made with essences containing iso e super and containing the composition in question in the same concentration instead of iso e super were firstly smelled from the bottle and sensory analysis was performed. According to the scoring system between 1 and 5, each of them received 4.79 points in terms of odor liking and odor strength in the test. The liquid detergent made with the same essence containing substitute composition received 4.47 points in terms of odor liking criteria and 4.21 points in terms of odor strength. In the second sensory analysis, the odor remaining in the fabrics was evaluated as a result of washing the fabrics of the same material in equal amounts with the same washing program in two separate washing machines with detergents made with the same essence containing the composition subject to the invention instead of iso e super. After washing, the average score of 4.83 was received in terms of liking and odor strength of the softener made with essence containing iso e super. According to the washing result of the detergent made with the same essence containing substitute composition instead of iso e super, it received 4.44 points in terms of liking in the panel test and 4.06 points in terms of odor power. As stated before, the acceptable score lower limit in sensory analyses should be at least 3 points. It is understood that a successful performance is provided by the above-mentioned results receiving values more than 3 and very close to the essence containing iso e super. In the evaluation of some physical analyses; the densities of essences in the baby shampoo, baby concentrated softener and baby liquid detergent category containing iso e super and non-allergenic substitute compositions were measured at 20°C. The density results in question are given in Table 8. Table 8. Density Test Results Density (g/cm3) Baby Liquid Baby shampoo Baby concentrate _ _ Softener used for essence test Essence used for essence test _ _ Refractive indexes of essences in the category of essence softener and baby liquid detergent containing non-allergenic substitution composition at 20°C were measured and the results are given in Table 9. Table 9. Refractive Index Test Results Refractive index Baby liquid Baby shampoo test _ detergent test Essence _ _ softener test _ _ Essence used for Essence containing non-allergenic substitution composition The flash points of essences in the baby shampoo, baby concentrated softener and baby liquid detergent category containing ISO e super and non-allergenic substitution compositions at 20°C were measured and the results are given in Table 10. 10 Table 10. Flash Points Test Results Flash point (OC) Baby shampoo Baby concentrated Baby liquid Essence used for softener test Essence used for essence test detergent test Essence used Non-allergenic substitution . . The changes in the density and refractive index of essences containing the composition 106 104 95, as seen in the tables given above, generally occur with a deviation in the range of ±1. When these essences are used in the finished products of baby shampoo at a concentration of 1%, in baby softener at a concentration of 1.5% and in liquid detergent at a concentration of 1%, the effect on the density change of the finished product is around 0.001%, which is a very small deviation. For this reason, it cannot be said that the substitute composition changes the density and refractive index values in the finished products significantly. The same situation applies to the flash point. The viscosities of baby shampoo, baby concentrated softener and baby liquid detergents were measured in comparison with the viscosity of essence-free baby shampoo, baby concentrated softener and baby liquid detergent bases. The measurements were made in centripoise with a rheometer and the results for each category are given in Tables 11, 12 and 13. Table 11. Baby Shampoo Viscosity Measurement Results Essence Viscosity (cp) Baby shampoo base 5900 shampoo 9200 baby shampoo using essence Table 12. Baby Concentrated Softener Viscosity Measurement Results Essence Viscosity (cp) Baby concentrated softener base 300 concentrated softener 460 baby concentrated softener using essence 405 Table 13. Baby Liquid Detergent Viscosity Measurement Results Essence Viscosity (cp) Baby liquid detergent base 330 detergent 785 baby liquid detergent using essence 650 It is normal for the viscosity to increase in the final product where essence is applied. For example, the viscosity of the baby shampoo base before adding essence is 5900 cp and after adding essence containing 1% concentration of iso e super, its viscosity is seen to increase to 9200 cp. The viscosity value of the baby shampoo prepared by using 1% concentration of essence containing the composition in question, which is non-allergenic, instead of 10% concentration of iso e super, was measured as 7400 cp. In this case, the viscosity increased from 5900 cp to 7400 cp. The important point here is that the viscosity of the baby shampoo should not fall to values lower than 5900 cp. Because some essence components can also have a viscosity-lowering effect. In such a case, the fluidity of the baby shampoo product will increase and the form of the product will deteriorate. The non-allergenic substitute composition developed instead of Iso e super, which is the subject of the invention, does not cause such a problem and can maintain the viscosity of the product to which it is applied above the minimum value. This is an effective feature of the non-allergenic substitute composition developed instead of iso e super. Any feature described in this specification (including the attached claims, summary, drawings) may be replaced by other alternative features that may have equivalent or similar purposes, unless explicitly stated otherwise. That is, unless explicitly stated otherwise, each feature is only an example of a series of equivalent or similar features. The above arrangements are intended only to explain the technical concept and features of the present invention, and the purpose of the present invention is to enable those skilled in the art to understand the content of the present invention and to apply the present invention, and the scope of the present invention is not limited to this. It is intended to include equivalent changes or modifications made in accordance with the spirit of the invention within the scope of the invention. Application of the Invention to Industry The invention is related to the structuring of an allergen-free fragrance composition developed as an alternative to the new allergen added as a raw material of essence in the European Union and is applicable to the industry. The invention is not limited to the above example applications, and a person skilled in the art can easily reveal other different applications of the invention. These should be evaluated within the scope of the protection requested by the claims of the invention.TR TR TR TR TR
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR2023018952A2 true TR2023018952A2 (en) | 2024-02-21 |
Family
ID=
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107530244A (en) | Concentrated type personal cleaning compositions and method | |
| CN107530246A (en) | Concentrated type personal cleaning compositions and method | |
| CN107530249A (en) | Concentrated type personal cleaning compositions and method | |
| CN1163217C (en) | Perfume composition | |
| CN107530247A (en) | Concentrated type personal cleaning compositions | |
| SE439019B (en) | DEODORANT COMPOSITION BAR CONTAINING A DETERGENT ACTIVE SUBSTANCE, A Perfume AND A NON-Perfuming Deodorant | |
| US8557262B2 (en) | Divinyl ether derivatives capable of releasing active aldehydes and ketones and methods of use for perfuming surfaces | |
| JPH0354300A (en) | Aromatic composition, and use thereof in detergent product | |
| EP2857482B1 (en) | Perfume composition | |
| CN107530248A (en) | Concentrated type personal cleaning compositions and method | |
| CN107922898A (en) | The Cleasing compositions of improved availability with beneficial agent | |
| JP2004538356A (en) | Fragrance delivery medium | |
| US20220031901A1 (en) | Fragrance composition | |
| JP2002317192A (en) | Fragrance composition | |
| KR101230933B1 (en) | Perfume Composition for Longlasting of Fragrance and the Method for Preparing thereof | |
| MX2015004976A (en) | Improvements in or relating to organic compounds. | |
| BR102016006550A2 (en) | compound, fragrance formulation, method for enhancing, enhancing or modifying a fragrance formulation, and, fragrance product | |
| TR2023018952A2 (en) | CONSTRUCTION OF AN ALLERGEN-FREE FRAGRANCE COMPOSITION | |
| BR102017026445B1 (en) | FRAGRANCE COMPOUND, FORMULATION AND PRODUCT, AND METHODS FOR IMPROVING, ENHANCEMENT OR MODIFYING A FRAGRANCE FORMULATION AND NEUTRALIZING AN UNPLEASANT ODOR IN AN AIR SPACE OR SUBSTRATE | |
| CN111936608A (en) | Musk composition | |
| BR102014026002B1 (en) | 3-(CYCLOEX-1-EN-1-ILA) PROPIONATES AND THEIR USES IN PERFUME COMPOSITIONS | |
| JP4375814B2 (en) | Macrocyclic musk mixture | |
| US20120107259A1 (en) | Method to improve skin and hair fragrance retention from personal care compositions | |
| US9816048B2 (en) | Organoleptic compounds | |
| US11965144B2 (en) | Perfume complex and perfumed water composition |