TR201915787A2 - Bosentan monohi̇drat yüklenmi̇ş sivi kendi̇li̇ği̇nden nanoemülsi̇fi̇ye i̇laç taşiyici si̇stem ve tablet formülasyonu - Google Patents
Bosentan monohi̇drat yüklenmi̇ş sivi kendi̇li̇ği̇nden nanoemülsi̇fi̇ye i̇laç taşiyici si̇stem ve tablet formülasyonuInfo
- Publication number
- TR201915787A2 TR201915787A2 TR2019/15787A TR201915787A TR201915787A2 TR 201915787 A2 TR201915787 A2 TR 201915787A2 TR 2019/15787 A TR2019/15787 A TR 2019/15787A TR 201915787 A TR201915787 A TR 201915787A TR 201915787 A2 TR201915787 A2 TR 201915787A2
- Authority
- TR
- Turkey
- Prior art keywords
- emulsive
- carrier system
- drug carrier
- tablet formulation
- bosentan monohydrate
- Prior art date
Links
- 239000007788 liquid Substances 0.000 title abstract 4
- GJPICJJJRGTNOD-UHFFFAOYSA-N bosentan Chemical compound COC1=CC=CC=C1OC(C(=NC(=N1)C=2N=CC=CN=2)OCCO)=C1NS(=O)(=O)C1=CC=C(C(C)(C)C)C=C1 GJPICJJJRGTNOD-UHFFFAOYSA-N 0.000 title abstract 2
- 229940036810 bosentan monohydrate Drugs 0.000 title abstract 2
- 239000003937 drug carrier Substances 0.000 title 1
- 239000007916 tablet composition Substances 0.000 title 1
- 229920002690 Polyoxyl 40 HydrogenatedCastorOil Polymers 0.000 abstract 2
- 239000003463 adsorbent Substances 0.000 abstract 2
- WECGLUPZRHILCT-GSNKCQISSA-N 1-linoleoyl-sn-glycerol Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC[C@@H](O)CO WECGLUPZRHILCT-GSNKCQISSA-N 0.000 abstract 1
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- JAUGGEIKQIHSMF-UHFFFAOYSA-N dialuminum;dimagnesium;dioxido(oxo)silane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[Mg+2].[Mg+2].[Al+3].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O.[O-][Si]([O-])=O JAUGGEIKQIHSMF-UHFFFAOYSA-N 0.000 abstract 1
- 125000005456 glyceride group Chemical group 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000003825 pressing Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 238000007711 solidification Methods 0.000 abstract 1
- 230000008023 solidification Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Buluş bosentan monohidrat içeren sıvı SNEDD sistemin adsorban bir taşıyıcıya adsorbe ettirilmesi (S-SNEDDS) tekniği ile toz halinin katı tablet formuna dönüştürülmesi ile ilgilidir. Sıvı SNEDD sistem belirli oranlarda Gliseril monolinoleat (Maisine®) - Polioksil 40 hidrojene hint yağı (Cremophor®RH 40) - Kaprilokaproil polioksil-8 gliseritlerinden (Labrasol®) oluşmuş, sıvı sistemin katılaştırılmasında adsorban olarak magnezyum aluminometasilikat (Neusilin® US2) kullanılmış ve doğrudan basım yöntemi ile tablet şekline getirilmiştir.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TR2019/15787A TR201915787A2 (tr) | 2019-10-14 | 2019-10-14 | Bosentan monohi̇drat yüklenmi̇ş sivi kendi̇li̇ği̇nden nanoemülsi̇fi̇ye i̇laç taşiyici si̇stem ve tablet formülasyonu |
PCT/TR2020/050945 WO2021076081A2 (en) | 2019-10-14 | 2020-10-13 | Bosentan monohydrate loaded liquid self nanoemulsifying drug carrier system and tablet formulation |
EP20876798.8A EP4045143A4 (en) | 2019-10-14 | 2020-10-13 | BOSENTAN MONOHYDRATE LOADED LIQUID SELF-NANOEMULSIFIING DRUG CARRIER SYSTEM AND TABLET FORMULATION |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TR2019/15787A TR201915787A2 (tr) | 2019-10-14 | 2019-10-14 | Bosentan monohi̇drat yüklenmi̇ş sivi kendi̇li̇ği̇nden nanoemülsi̇fi̇ye i̇laç taşiyici si̇stem ve tablet formülasyonu |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201915787A2 true TR201915787A2 (tr) | 2021-04-21 |
Family
ID=75538003
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2019/15787A TR201915787A2 (tr) | 2019-10-14 | 2019-10-14 | Bosentan monohi̇drat yüklenmi̇ş sivi kendi̇li̇ği̇nden nanoemülsi̇fi̇ye i̇laç taşiyici si̇stem ve tablet formülasyonu |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP4045143A4 (tr) |
TR (1) | TR201915787A2 (tr) |
WO (1) | WO2021076081A2 (tr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023240348A1 (en) * | 2022-06-14 | 2023-12-21 | Empowerpharm Inc. | Pharmaceutical composition for oral administration of cannabinoids |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6116905B2 (ja) * | 2009-10-23 | 2017-04-19 | プロノヴァ・バイオファーマ・ノルゲ・アーエスPronova BioPharma Norge AS | 脂肪酸油混合物の被覆型カプセル剤および錠剤 |
WO2012139736A1 (en) * | 2011-04-11 | 2012-10-18 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Pharmaceutical composition comprising bosentan |
WO2015100406A1 (en) * | 2013-12-26 | 2015-07-02 | Clarus Therapeutics, Inc. | Use of oral pharmaceutical products combining testosterone esters with hypolipidemic agents |
WO2016124966A1 (en) * | 2014-12-23 | 2016-08-11 | Drug Discovery Laboratory As | Inclusion complex between cyclodextrin and non-ionic surfactants |
-
2019
- 2019-10-14 TR TR2019/15787A patent/TR201915787A2/tr unknown
-
2020
- 2020-10-13 WO PCT/TR2020/050945 patent/WO2021076081A2/en unknown
- 2020-10-13 EP EP20876798.8A patent/EP4045143A4/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2021076081A2 (en) | 2021-04-22 |
EP4045143A2 (en) | 2022-08-24 |
EP4045143A4 (en) | 2023-11-08 |
WO2021076081A3 (en) | 2021-06-17 |
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