TR201719941A2 - NATURAL DISINFECTANT SOLUTION - Google Patents
NATURAL DISINFECTANT SOLUTION Download PDFInfo
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- TR201719941A2 TR201719941A2 TR2017/19941A TR201719941A TR201719941A2 TR 201719941 A2 TR201719941 A2 TR 201719941A2 TR 2017/19941 A TR2017/19941 A TR 2017/19941A TR 201719941 A TR201719941 A TR 201719941A TR 201719941 A2 TR201719941 A2 TR 201719941A2
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- disinfectant solution
- extract
- natural disinfectant
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 38
- 229910021538 borax Inorganic materials 0.000 claims abstract description 12
- 239000004328 sodium tetraborate Substances 0.000 claims abstract description 12
- 235000010339 sodium tetraborate Nutrition 0.000 claims abstract description 12
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims abstract description 10
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 claims description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- 235000019441 ethanol Nutrition 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 3
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 abstract description 2
- WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 abstract 1
- 229940030275 epigallocatechin gallate Drugs 0.000 abstract 1
- 239000000126 substance Substances 0.000 description 16
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 14
- 230000000694 effects Effects 0.000 description 11
- 239000000203 mixture Substances 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 238000004140 cleaning Methods 0.000 description 9
- 229910000831 Steel Inorganic materials 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000010959 steel Substances 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- 235000013305 food Nutrition 0.000 description 5
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 4
- 244000269722 Thea sinensis Species 0.000 description 4
- 229910052796 boron Inorganic materials 0.000 description 4
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 4
- 235000005487 catechin Nutrition 0.000 description 4
- XMOCLSLCDHWDHP-IUODEOHRSA-N epi-Gallocatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-IUODEOHRSA-N 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 235000013616 tea Nutrition 0.000 description 4
- 239000002351 wastewater Substances 0.000 description 4
- 241000193749 Bacillus coagulans Species 0.000 description 3
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 230000032770 biofilm formation Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000000460 chlorine Substances 0.000 description 3
- 229910052801 chlorine Inorganic materials 0.000 description 3
- 229950001002 cianidanol Drugs 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- XMOCLSLCDHWDHP-UHFFFAOYSA-N L-Epigallocatechin Natural products OC1CC2=C(O)C=C(O)C=C2OC1C1=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-UHFFFAOYSA-N 0.000 description 2
- 230000003064 anti-oxidating effect Effects 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- DZYNKLUGCOSVKS-UHFFFAOYSA-N epigallocatechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3cc(O)c(O)c(O)c3 DZYNKLUGCOSVKS-UHFFFAOYSA-N 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 229940035535 iodophors Drugs 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 235000014571 nuts Nutrition 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- PFTAWBLQPZVEMU-HIFRSBDPSA-N (-)-catechin Chemical compound C1([C@@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-HIFRSBDPSA-N 0.000 description 1
- RPNUMPOLZDHAAY-UHFFFAOYSA-N Diethylenetriamine Chemical compound NCCNCCN RPNUMPOLZDHAAY-UHFFFAOYSA-N 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- 241000588914 Enterobacter Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 240000006711 Pistacia vera Species 0.000 description 1
- 235000003447 Pistacia vera Nutrition 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- PCSMJKASWLYICJ-UHFFFAOYSA-N Succinic aldehyde Chemical compound O=CCCC=O PCSMJKASWLYICJ-UHFFFAOYSA-N 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 229940054340 bacillus coagulans Drugs 0.000 description 1
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 description 1
- 239000012964 benzotriazole Substances 0.000 description 1
- -1 boron ions Chemical class 0.000 description 1
- 150000001765 catechin Chemical class 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000013000 chemical inhibitor Substances 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- NKSJNEHGWDZZQF-UHFFFAOYSA-N ethenyl(trimethoxy)silane Chemical compound CO[Si](OC)(OC)C=C NKSJNEHGWDZZQF-UHFFFAOYSA-N 0.000 description 1
- 150000002214 flavonoid derivatives Chemical class 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 229940094952 green tea extract Drugs 0.000 description 1
- 235000020688 green tea extract Nutrition 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 206010023497 kuru Diseases 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 235000020233 pistachio Nutrition 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 230000018612 quorum sensing Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Buluş, epigallokateşin gallat ekstraktı, boraks ekstraktı ve etilendiamin tetraasetik asit içeren doğal dezenfektan solüsyonu ile ilgilidir.The invention relates to a natural disinfectant solution containing epigallocatechin gallate extract, borax extract and ethylenediamine tetraacetic acid.
Description
TARIFNAME DOGAL DEZENFEKTAN SOLÜSYON Teknik Alan Bulus, gida üretim hatti ve alanlarinin temizliginde kullanilan, etkin dezenfeksiyon etkisi olan dogal bir dezenfektan solüsyon ile ilgilidir. DESCRIPTION NATURAL DISINFECTANT SOLUTION Technical Area Invention, effective disinfection used in the cleaning of food production lines and areas. It is about a natural disinfectant solution that has an effective effect.
Bulus daha özel olarak, epigallokatesin gallat ekstrakti, boraks ekstrakti ve etilendiamin tetraasetik asit içeren dogal dezenfektan solüsyonu ile ilgilidir. Önceki Teknik Günümüzde gida üretim hatti ve alanlari hijyen ve sanitasyonu için termal ve kimyasal yöntemlerin yani sira radyasyon gibi yöntemler kullanilmaktadir. Termal uygulamalara örnek olarak kaynamis su, sicak su ve sicak buhar; kimyasal uygulamalara örnek olarak da klor, asit, iyodoforlar ve hidrojen peroksit veya perasetik asit verilebilir (Tetrapak, 1995). Diger taraftan temizlik ve dezenfeksiyonda kullanilan kimyasallar atik sulara karismakta ve önemli aritma maliyetlerine sebep olabilmektedir (Tetrapak, 1995; Metin ve Öztürk, 2003; Kayaardi, 2014). Termal ve kimyasal uygilamalar yani sira radyasyon (UV) uygulamasi da kullanilmaktadir. UV isletmelerde genellikle hava temizligi ve biçaklarin temizliginde kullanilmaktadir (Metin ve Öztürk, 2003). Klor ve iyodoforlar, temizlik sonrasi olusan atik sularda toksik bazi maddelerin (trihalometanlar ve haloasetik) olusumuna sebep olmaktadir. Asit ise yüzeyler üzerine korozif etki yaratmaktadir. Perasetik asit atik sularinda klor gibi toksik yan ürünler (trihalometanlar ve haloasetik) maddeler olusturmadigi; fakat atik sularinin Biyokimyasal oksijen ihtiyaci tayini (BOD) ve kimyasal oksijen ihtiyaci (COD) degerlerini arttirdigi bildirilmistir. Fakat son derece korozif olan dezenfektan madde, üzerinde biyofilm olusmus yüzeylerde serbest radikallerin olusmasina neden oldugu bilinmektedir. Yapilan çalismalarda perasetik asitin düsük konsantrasyonlarda (S %1) kullanima uygun oldugu bildirilirken; stabil bir ürün olmadigi gösterilmistir. Bununla birlikte perasetik asitin biyofilm içerindeki kimyasal yapilari okside ederek; yapismayi saglayan yapilarin ve kovalent baglarin yüzeye iyice yapismasina neden oldugu bildirilmektedir. Su kullanimi ise perasetik asitin korozif etkisini azaltmak ile birlikte biyofilmler üzerine olumsuz etkisini Vural ve Çelen, 2005; Dell°Erba ve ark., 2007). More specifically, the invention deals with epigallocatecin gallate extract, borax extract and It relates to a natural disinfectant solution containing ethylenediamine tetraacetic acid. Prior Art Today, for the hygiene and sanitation of food production lines and areas, thermal and In addition to chemical methods, methods such as radiation are used. Thermal examples of applications are boiled water, hot water and hot steam; chemical Examples of applications are chlorine, acid, iodophors and hydrogen peroxide or peracetic acid can be given (Tetrapak, 1995). On the other hand, cleaning and The chemicals used in disinfection are mixed with the wastewater and important treatment may cause costs (Tetrapak, 1995; Metin and Öztürk, 2003; Kayaardi, 2014). Thermal and chemical applications as well as radiation (UV) application is also used. In UV businesses, air cleaning and It is used in the cleaning of knives (Metin and Öztürk, 2003). chlorine and iodophors, some toxic substances in waste water after cleaning (trihalomethanes and haloacetic) formation. Acid surfaces creates a corrosive effect on it. Toxic side effects such as chlorine in peracetic acid wastewater the products (trihalomethanes and haloacetic) do not form substances; but wastewater Determination of biochemical oxygen demand (BOD) and chemical oxygen demand (COD) reported to increase their value. But highly corrosive disinfectant The substance prevents the formation of free radicals on the surfaces on which biofilm has formed. known to cause Studies have shown that peracetic acid has a low While it is reported that it is suitable for use in concentrations (S 1%); a stable product has not been shown. However, peracetic acid in the biofilm by oxidizing chemical structures; bonding structures and covalent bonds It is reported that it causes good adhesion to the surface. Water use is peracetic. Along with reducing the corrosive effect of acid, its negative effect on biofilms Vural and Çelen, 2005; Dell°Erba et al., 2007).
UV ise maliyet nedeniyle daha çok biçaklarin dezenfeksiyonu için kullanilmaktadir. UV is mostly used for disinfection of blades due to cost. is used.
Teknikte dezenfektan etkisi olan temizlik bilesimleri için çesitli gelistirmeler yapilmistir. Various improvements for cleaning compositions with disinfectant effect in the technique has been made.
Teknigin bilinen durumunda yer alan CN104031764 sayili Çin patent dokümaninda, gelistirilen bir temizlik maddesi bilesiminden bahsedilmektedir. Chinese patent number CN104031764 in the state of the art In the document, a developed cleaning agent composition is mentioned.
Bilesim; alkol, su, boraks ve katesinleri içermektedir. Gelistirilen bilisim iyi temizleme ve çevre dostu özelligine sahiptir. Bu dokümanda yer alan katesin (Cas No: 18829-70-4) maddesi çay içerisinde bulunan bir fenolik maddedir (Formül I). dokümaninda, etken maddesi olarak yesil çay özü ihtiva eden antivirütik aktiviteye sahip bir temizlik veya dezenfeksiyon bilesimi hazirlamak için gelistirilen bilesim ve bu bilesimin elde edilmesinden bahsedilmektedir. Bilesimde yer alan yesil çay özütü, katesin, epikatesin, epigallokatekin (EGC), epikatesin galat (EKG), epigallokatesin galat (EGCG) ve benzeri flavonoid türevlerini içerebilmektedir. Compound; It contains alcohol, water, borax and catechins. Developed informatics is good It has cleaning and environmental friendly features. The catechin (Cas) No: 18829-70-4) is a phenolic substance (Formula I) found in tea. In the document, it has antiviral activity containing green tea extract as its active ingredient. composition developed to prepare a cleaning or disinfecting composition with and obtaining this composition. Green tea in the composition extract, catechin, epicatecin, epigallocatechin (EGC), epicatecin gallate (EKG), may contain epigallocatecin gallate (EGCG) and similar flavonoid derivatives.
Bilesimde dengeleyici olarak etilendiamin tetraasetik asit de kullanilmaktadir. karisim kullanilmistir. Çay ektrakti hazirlanmasi için etilalkol, isopropil alkol v.b. alkoller kullanilmistir. Ancak bu dokümanda yer alan bilesimin formülünde epigallokatesin galat (EGCG) kullanilmamis; çay ekstrakti kullanilmistir. Çay ekstraktinin içinde ECGC oldugu bilinmektedir. Ancak EGCG ekstrakti etkisinin baska maddelerin etkisinden etkilendigi mevcut bulus ile gösterilmistir. Ethylenediamine tetraacetic acid is also used as a stabilizer in the composition. mix is used. For the preparation of tea extract, ethyl alcohol, isopropyl alcohol, etc. alcohols are used. However, in the formula of the composition in this document, epigallocatecin gallate (EGCG) was not used; tea extract was used. Tea It is known that the extract contains ECGC. However, the effect of EGCG extract It has been shown by the present invention that it is affected by the effect of other substances.
Teknigin bilinen durumunda yer alan CN105907197 sayili Çin patent dokümaninda, anti-oksidasyon metal yüzey muamele etkin maddesinden bahsedilmektedir. Bu madde agirlikça, 0.4-O.5 parça boraks, 40-50 parça polivinil gliserol, O.6-O.8 parça trietanolamin, 6-8 parça benzotriazol, 6-7 parça sodyum beiizoat, 2-3 parça sodyum dodesil sülfat, 0.4-0.6 parça bütanedial, 4-5 parça nano- kristalin selüloz 0.3-0.4 parça dietilentriamin, 0.32-O.4 parça vinil trimetoksi silan, 0.4-0.6 parça etetat disodyum ve uygun bir miktarda deiyonize su içermektedir. Chinese patent number CN105907197 in the state of the art In the document, anti-oxidation metal surface treatment active agent is mentioned. By weight, this substance is 0.4-0.5 parts borax, 40-50 parts polyvinyl glycerol, 0.6-0.8 parts triethanolamine, 6-8 parts benzotriazole, 6-7 parts sodium beiizoate, 2-3 parts sodium dodecyl sulfate, 0.4-0.6 parts butanedial, 4-5 parts nano- crystalline cellulose 0.3-0.4 parts diethylenetriamine, 0.32-0.4 parts vinyl trimethoxy silane, It contains 0.4-0.6 parts of etetate disodium and an appropriate amount of deionized water.
Bulus ile gelistirilen madde, metal yüzeyler üzerinde iyi anti oksidasyon, anti-pas ve anti-korozyon etkisine sahiptir. Ancak bu dokümanda da katesin kullanilmistir. The substance developed by the invention has good anti-oxidation, anti-rust properties on metal surfaces. and has anti-corrosion effect. However, catechin is also used in this document.
(Formül 1). Örnek gösterilen patent dokümanlarinda yer alan bilesimler içerdikleri kimyasallardan dolayi sade, dogal ve çevre dostu degillerdir. Dolayisiyla bulus konusu dogal dezenfektan solüsyonunun gelistirilmesi ihtiyaci duyulmustur. (Formula 1). The compositions in the exemplary patent documents contain they are not plain, natural and environmentally friendly due to chemicals. Therefore, find There was a need to develop a natural disinfectant solution in question.
Bulusun Amaçlari Bu bulusun amaci, dogal ve çevre dostu dogal dezenfektan solüsyonunun gerçeklestirilmesidir. Objectives of the Invention The aim of this invention is to produce natural and environmentally friendly natural disinfectant solution. is realization.
Bu bulusun bir baska amaci, hizli temizleme özelligine sahip dogal dezenfektan solüsyonunun gerçeklestirilmesidir. Another purpose of this invention is natural disinfectant with fast cleaning feature. realization of the solution.
Bu bulusun bir baska amaci, epigallokatesin gallat ekstrakti, boraks ekstrakti ve etilendiamin tetraasetik asit içeren dogal dezenfektan solüsyonunun gerçeklestirilmesidir. Another object of this invention is epigallocatecin gallate extract, borax extract and of a natural disinfectant solution containing ethylenediamine tetraacetic acid. is realization.
Bu bulusun bir baska amaci, aritma maliyetlerini azaltan dogal dezenfektan solüsyonunun gerçeklestirilmesidir. Another aim of this invention is natural disinfectant which reduces treatment costs. realization of the solution.
Bu bulusun bir baska amaci, mikroorganizmalarin ortami algilama sistemlerini inhibe ederek biyofilm olusturmalarini engelleyen dogal dezenfektan solüsyonunun gerçeklestirilmesidir. Another object of this invention is to provide environment sensing systems of microorganisms. of natural disinfectant solution that prevents biofilm formation by inhibiting is realization.
Bulusun Ayrintili Açiklamasi Bulus, dogal dezenfektan solüsyonu olup; - epigallokatesin gallat ekstrakti - boraks ekstrakti - etilendiamin tetraasetik asit (EDTA) içermektedir. Detailed Description of the Invention The invention is a natural disinfectant solution; - epigallocatecin gallate extract - borax extract - ethylenediamine tetraacetic acid (EDTA) contains.
Bulus, dogal dezenfektan solüsyonu olup kullanilan epigallokatesin gallat (Cas No: 989-51-5) ekstrakti Formül (llYdeki gibidir. The invention is a natural disinfectant solution and used epigallocatecin gallate (Cas No: 989-51-5) extract as in Formula (IIY).
Bulus, dogal dezenfektan solüsyonu olup; epigallokatesin gallat ekstrakti lmg/ml Bulus, dogal dezenfektan solüsyonu olup; boraks ekstrakti lmg/ml %70 etil alkol ile hazirlanmistir. The invention is a natural disinfectant solution; epigallocatecin gallate extract Lmg/ml The invention is a natural disinfectant solution; borax extract lmg/ml 70% ethyl alcohol is prepared with.
Bulus, dogal dezenfektan solüsyonu olup; hacimce %25 epigallokatesin gallat ekstrati, %25 boraks ekstrakti ve %50 oraninda %0,32 su ile hazirlanan etilendiamin tetraasetik asit (EDTA) içermektedir. The invention is a natural disinfectant solution; 25% by volume epigallocatecin gallate extract, 25% borax extract and 50% water prepared with 0.32% water. Contains ethylenediamine tetraacetic acid (EDTA).
Madde Kombinasyon Karisma %Inhibisyon Maddesi Orani Epigallokatesin gallat ve Boraks Yok %0,32 EDTA - %19 Tablo 1: Dogal dezenfektan solüsyonunun içerigi Dogal dezenfektan solüsyon formülünün etkinligi invitro sartlarda ultra yüksek isili (UHT) süt içerisinde; 24 saatlik biyofilm olusumu saglanmis çelik plaka 316 L kuponlarin üzerinde arastinlmistir. Kültür olarak üretim hatlarinda siklikla biyofilm olusturdugu tespit edilen güçlü biyofîlm üreticisi ve iletisim kimyasali sinyali (quorum sensing) aktivitesi bulunan Bacillus coagulans ve Enterobacter cloacea kullanilmistir. Biyofilm olusturan ve sesil hücre sayilari herhangi bir islem uygulanmamis çelik plaka yüzey, sadece yerinde temizlik prosedürü (CIP) (70- su) uygulanmis yüzey, CIP sonrasi ticari bir dezenfektan madde olan perasetik asit ve protect-mature isimli dogal dezenfektan maddenin uygulamasi sonucu tespit ark (2012) tarafindan yapilan çalismalarda kullanilan yöntemlere uygun olarak çalismada süte son hücre konsantrasyonu 104'5 kob/ml olacak sekilde izolatlar inoküle edilmistir. 30°C/24 saat inkübasyon yapilmasinin ardindan mikroorganizma hücre sayilari belirlenmistir. Substance Combination Mixing %Inhibition Item Ratio epigallocatecin gallate and borax None 0.32% EDTA - 19% Table 1: Content of the natural disinfectant solution The effectiveness of the natural disinfectant solution formula in in vitro conditions with ultra-high heat (UHT) in milk; Steel plate with 24-hour biofilm formation 316 L Searched on coupons. As a culture, biofilm is frequently used in production lines. strong biofilm producer and communication chemical signal (quorum sensing) activity of Bacillus coagulans and Enterobacter cloacea used. Biofilm-forming and sessile cell numbers unapplied steel plate surface, clean-in-place procedure only (CIP) (70- water) treated surface, peracetic acid, a commercial disinfectant after CIP and detection as a result of the application of a natural disinfectant substance called protect-mature. In accordance with the methods used in the studies by ark (2012) In the study, isolates were isolated in milk with a final cell concentration of 104'5 cfu/ml. is inoculated. After incubation at 30°C/24 hours Microorganism cell numbers were determined.
E.cloacea sesil hücre sayisi hiçbir islem uygulanmamis çelik plakalar üzerinde 6 logkob/cm2 olarak tespit edilirken; CIP uygulandiginda bu sayinin 2 logaritmik deger, ticari perasedik asitlin 15 dakika uygulanmasi sonucu 5 logaritmik deger azaldigi belirlenmistir. Gelistirilen dogal dezenfektan solüsyonunun 5 dakika uygmlanmasi sonucunda sesi] hücre sayisi tespit edilebilir seviyenin altinda bulunmustur (6 logaritmik deger azalma gerçeklesmistir). E.cloacea biyofilm hücre sayisi hiçbir islem uygulanmamis çelik plakalar üzerinde 6 logkob/cm2 olarak tespit edilirken; CIP uygulandiginda bu sayinin 2 logaritmik deger, ticari perasedik asit dezenfektanin 5 dakika uygulamasi 5 logaritmik deger hücre sayisini azaltabilirken; dakika uygulama ile hücre sayisi tespit edilebilir seviyenin altinda bulunmustur. E.cloacea sessile cell count was 6 on untreated steel plates. While it is detected as logkob/cm2; When CIP is applied, this number is 2 logarithmic value is 5 logarithmic value after 15 minutes of commercial peracetic acid application. decrease has not been determined. 5 minutes of the developed natural disinfectant solution As a result of the application, the number of cells] is below the detectable level. was found (6 logarithmic value reduction occurred). E.cloacea biofilm cell The number was determined as 6 logkob/cm2 on untreated steel plates. while doing; 2 logarithmic value of this number when CIP is applied, commercial peracedic acid 5 minutes application of disinfectant can reduce the number of 5 logarithmic cells; The number of cells was found below the detectable level with minutes of application.
Dogal dezenfektan solüsyonunu kullanildiginda ise 5 dakikalik uygulama sonucunda biyofilm hücre sayisi tespit edilebilir seviyenin altinda bulunmustur (6 logaritmik deger azalma gerçeklesmistir). When using the natural disinfectant solution, a 5-minute application As a result, the number of biofilm cells was found below the detectable level (6 logarithmic value decrease).
B.coagulans sesil hücre sayisi hiçbir islem uygulanmamis çelik plakalar üzerinde 6 logkob/cm2 olarak tespit edilirken; CIP uygulandiginda bu sayinin 1 logaritmik deger, ticari perasedik asitsin 15 dakika uygulanmasi sonucu 5 logaritmik deger azaldigi belirlenmistir. Dogal dezenfektan solüsyonu kullanildiginda ise 5 dakikalik uygulama sonucunda sesil hücre sayisi tespit edilebilir seviyenin altinda bulunmustur (6 logaritmik deger azalma gerçeklesmistir). B.coagulans biyofilm hücre sayisi hiçbir islem uygulanmamis çelik plakalar üzerinde 5 logkob/cm2 olarak tespit edilirken; CIP uygulandiginda bu sayinin 1 logaritmik deger, ticari perasedik asit dezenfektanin 5 dakika uygulamasi 3 logaritmik deger hücre sayisini azaltabilirken; 15 dakika uygulama ile hücre sayisi 4 logaritmik deger azaldigi tespit edilmistir. Dogal dezenfektan solüsyonunu kullanildiginda ise 5 dakikalik uygulama sonucunda biyofilm hücre sayisi tespit edilebilir seviyenin altinda bulunmustur (6 logaritmik deger azalma gerçeklesmistir). The number of B.coagulans sessile cells was 6 on untreated steel plates. While it is detected as logkob/cm2; When CIP is applied, this number is 1 logarithmic. value is 5 logarithmic value after 15 minutes of commercial peracetic acid application. decrease has not been determined. When using a natural disinfectant solution, 5 minutes As a result of the application, the number of sessile cells is below the detectable level. was found (6 logarithmic value reduction occurred). B. coagulans biofilm cell number as 5 logkob/cm2 on untreated steel plates while being detected; When CIP is applied, 1 logarithmic value of this number is 5 minutes application of acid disinfectant 3 logarithmic value determines the number of cells. while reducing; The number of cells decreased by 4 logarithmic values with 15 minutes of application. has been detected. When using the natural disinfectant solution, 5 minutes As a result of the application, the number of biofilm cells is below the detectable level. was found (6 logarithmic value reduction occurred).
Dogal dezenfektan solüsyonu formülünün 5 ve 15 dakikalik uygulamasi sesil hücrelerle birlikte biyofilm olusturabilen hücrelerin sayilarini tespit edilebilir seviyenin altina indirebilmektedir. 5 dakikalik uygulama dogal dezenfektan solüsyonunu için yeterli olmakta ve bu süre hizin önemli oldugu gida sanayi için ciddi bir süre azalmasi anlamina gelmektedir. 5 and 15 minutes application of natural disinfectant solution formula sesil the number of cells that can form a biofilm together with the cells can be determined can lower the level. 5-minute application natural disinfectant It is sufficient for the solution and this time is for the food industry where speed is important. It means a significant time reduction.
Dogal dezenfektan solüsyonu kullanildiginda %10,6 oraninda bor iyonun yüzeyde bulundugu tespit edilmistir. Dezenfeksiyon islemi sonrasi su ile durulama islemi yapilmadiginda; kabaca formül kullanimiyla 0,16 mg/cm2 borun yüzeyde kaldigi söylenebilir. Bor toprak, deniz ve havada dogal olarak var olan; içtigimiz sularda, yedigimiz meyve, sebze ve kuru yemislerde bulunan dogal bir mineraldir. En yüksek oranda kabuklu kuruyemislerde bulunur. Örnegin fistik da 13,8-18 ug/g, 14,33 ug/gldir. Dünya Saglik Örgütü WHO°ya göre içme sularinda bor siniri 0,1 - 0,3 mg/L olarak belirlenirken; Avrupa Gida Güvenligi Otoritesi-EFSA ise bu siniri 0,2-0,6 mg/gün olarak belirlemistir (Kuru ve Yarat, 2017). When a natural disinfectant solution is used, 10.6% of boron ions are on the surface. has been detected. Rinsing with water after disinfection not done; Roughly using the formula, 0.16 mg/cm2 of boron remains on the surface. can be said. Boron exists naturally in the soil, sea and air; in the water we drink, It is a natural mineral found in the fruits, vegetables and nuts we eat. Most It is found in high levels of shelled nuts. For example, 13.8-18 ug/g in pistachio, 14.33 ug/gl. According to the World Health Organization WHO, the boron limit in drinking water is 0.1 - While it was determined as 0.3 mg/L; The European Food Safety Authority-EFSA limits this limit. 0.2-0.6 mg/day (Kuru and Yarat, 2017).
Mevcut bulus ile gelistirilen dogal dezenfektan solüsyonun, yüzeyler üzerine korozif etkisi olmayip CIP prosedürü sonrasi yüzeydeki zarari bile olumluya çevirebilmektedir. Tamamen dogal maddeler ile hazirlandigindan aritma sularinda toksik madde olusumu görülmeyeceginden aritma maliyetleri azalacaktir. The natural disinfectant solution developed with the present invention is applied to the surfaces. It has no corrosive effect and even the damage on the surface after the CIP procedure is positive. can translate. Since it is prepared with completely natural substances, it can be used in treatment waters. Since toxic substance formation will not be seen, treatment costs will decrease.
Dogal dezenfektan solüsyonun antimikrobiyal olmasindan dolayi yüzeylerde hali hazirda var olan biyofilmler üzerine etkili olabilirken; iletisim kimyasali inhibitörü (antiquorum sensing) özelligi sebebiyle mikroorganizmalarin ortami algilama sistemlerini inhibe ederek biyofilm olusturrnalarinin önüne geçilmektedir. Carpet on surfaces due to the antimicrobial nature of the natural disinfectant solution. while it can be effective on existing biofilms; communication chemical inhibitor Microorganisms cannot detect the environment due to its (antiquorum sensing) feature. By inhibiting biofilm systems, biofilm formation is prevented.
Gelistirilen dogal dezenfektan solüsyon, özellikle gida üretim yüzeylerinin büyük bir çogunlugu olan paslanmaz çelik 316 L üzerindeki mikrobiyal yükü (sesil ve biyofilm olusturabilen hücre sayisi) 5 dakikalik uygulama sonucunda 6 logaritmik deger azaltabilmektedir.The developed natural disinfectant solution is especially suitable for large areas of food production surfaces. microbial load (sessile and number of cells that can form biofilm) 6 logarithmic after 5 minutes of application value can be reduced.
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| PCT/TR2018/050710 WO2019132826A2 (en) | 2017-12-08 | 2018-11-21 | Natural disinfectant solution |
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