TR201708347T4 - Other new forms of intrusive rna molecules. - Google Patents
Other new forms of intrusive rna molecules. Download PDFInfo
- Publication number
- TR201708347T4 TR201708347T4 TR2017/08347T TR201708347T TR201708347T4 TR 201708347 T4 TR201708347 T4 TR 201708347T4 TR 2017/08347 T TR2017/08347 T TR 2017/08347T TR 201708347 T TR201708347 T TR 201708347T TR 201708347 T4 TR201708347 T4 TR 201708347T4
- Authority
- TR
- Turkey
- Prior art keywords
- chain
- ribonucleic acid
- intrusive
- rna molecules
- new forms
- Prior art date
Links
- 229920002477 rna polymer Polymers 0.000 abstract 5
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 230000000295 complement effect Effects 0.000 abstract 1
- 230000014509 gene expression Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/11—Protein-serine/threonine kinases (2.7.11)
- C12Y207/11001—Non-specific serine/threonine protein kinase (2.7.11.1), i.e. casein kinase or checkpoint kinase
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
- C12N2310/3183—Diol linkers, e.g. glycols or propanediols
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C—CHEMISTRY; METALLURGY
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/343—Spatial arrangement of the modifications having patterns, e.g. ==--==--==--
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3521—Methyl
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3525—MOE, methoxyethoxy
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
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- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
- C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance
Abstract
Mevcut buluş bir ribonükleik asitle, bu tür bir ribonükleik asidin kullanımıyla, bu tür ribonükleik asidi içeren bir kompozisyonun kullanımıyla, bu tür ribonükleik asidi içeren bir farmasötik kompozisyonun kullanımıyla ve hedefteki bir gen ekspresyonunun inhibe edilmesine yönelik bir metotla ilgili olup; söz konusu ribonükleik asit çift zincirli bir yapıya sahiptir; söz konusu çift zincirli yapı bir birinci zinciri ve bir ikinci zinciri içerir; söz konusu birinci zincir bitişik nükleotitlere ait bir birinci dizilime (stretch) sahiptir ve bu birinci dizilim de hedefteki nükleik aside hiç değilse kısmen komplementer özelliktedir; söz konusu ikinci zincir bitişik nükleotitlere ait bir ikinci dizilime sahiptir ve bu ikinci dizilim de hedefteki nükleik aside hiç değilse kısmen özdeş olmasıyla ilgilidir.The present invention relates to a ribonucleic acid, the use of such a ribonucleic acid, the use of a composition comprising such ribonucleic acid, the use of a pharmaceutical composition containing such ribonucleic acid, and a method of inhibiting a gene expression in the target; said ribonucleic acid has a double stranded structure; said double chain structure includes a first chain and a second chain; said first chain has a first stretch of adjacent nucleotides, which first sequence is at least partially complementary to the nucleic acid of the target; said second chain has a second sequence of adjacent nucleotides, and this second sequence relates to being at least partially identical to the target nucleic acid.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02017601A EP1389637B1 (en) | 2002-08-05 | 2002-08-05 | Blunt-ended interfering RNA molecules |
US40254102P | 2002-08-12 | 2002-08-12 | |
EP03008383 | 2003-04-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201708347T4 true TR201708347T4 (en) | 2019-02-21 |
Family
ID=44292685
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2018/16291T TR201816291T4 (en) | 2002-08-05 | 2003-08-05 | Additional new forms of intrusive RNA molecules. |
TR2017/08347T TR201708347T4 (en) | 2002-08-05 | 2003-08-05 | Other new forms of intrusive rna molecules. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2018/16291T TR201816291T4 (en) | 2002-08-05 | 2003-08-05 | Additional new forms of intrusive RNA molecules. |
Country Status (7)
Country | Link |
---|---|
JP (1) | JP4705370B2 (en) |
KR (1) | KR20120029002A (en) |
ES (3) | ES2695050T3 (en) |
HU (3) | HUE039866T2 (en) |
PT (3) | PT1857547T (en) |
SI (1) | SI1527176T1 (en) |
TR (2) | TR201816291T4 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070265220A1 (en) * | 2004-03-15 | 2007-11-15 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
RU2553561C2 (en) * | 2006-07-21 | 2015-06-20 | Сайленс Терапьютикс Аг | Means for inhibiting proteinkinase 3 expression |
JP5540312B2 (en) * | 2008-02-15 | 2014-07-02 | 独立行政法人理化学研究所 | Circular single-stranded nucleic acid complex and method for producing the same |
CN105907756A (en) * | 2008-12-18 | 2016-08-31 | 戴瑟纳制药公司 | Extended Dicer Substrate Agents And Methods For The Specific Inhibition Of Gene Expression |
JP2012147677A (en) * | 2009-05-14 | 2012-08-09 | Nippon Shinyaku Co Ltd | Modified double-stranded rna |
EP3358014B1 (en) * | 2010-04-19 | 2020-12-23 | TAGCyx Biotechnologies Inc. | Method for stabilizing functional nucleic acids |
US20110306653A1 (en) | 2010-05-14 | 2011-12-15 | Tagcyx Biotechnologies | Stabilization method of functional nucleic acid |
EP2616543A1 (en) * | 2010-09-15 | 2013-07-24 | Alnylam Pharmaceuticals, Inc. | MODIFIED iRNA AGENTS |
JP7050277B2 (en) * | 2017-11-10 | 2022-04-08 | 久美子 程 | RNA molecule |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ277617A (en) * | 1993-11-16 | 1998-01-26 | Genta Inc | Chimeric oligonucleoside compounds useful in activating rnaseh mediated cleavage of ribonucleic acid sequences |
DE10160151A1 (en) * | 2001-01-09 | 2003-06-26 | Ribopharma Ag | Inhibiting expression of target gene, useful e.g. for inhibiting oncogenes, by administering double-stranded RNA complementary to the target and having an overhang |
EP2345742B1 (en) * | 2000-03-30 | 2014-06-11 | The Whitehead Institute for Biomedical Research | RNA sequence-specific mediators of RNA interference |
US20030190635A1 (en) * | 2002-02-20 | 2003-10-09 | Mcswiggen James A. | RNA interference mediated treatment of Alzheimer's disease using short interfering RNA |
CZ308053B6 (en) * | 2000-12-01 | 2019-11-27 | Max Planck Gesellschaft | Isolated double-stranded RNA molecule, process for producing it and its use |
-
2003
- 2003-08-05 SI SI200330726T patent/SI1527176T1/en unknown
- 2003-08-05 HU HUE17160954A patent/HUE039866T2/en unknown
- 2003-08-05 ES ES17160954.8T patent/ES2695050T3/en not_active Expired - Lifetime
- 2003-08-05 HU HUE10012263A patent/HUE032289T2/en unknown
- 2003-08-05 PT PT60271293T patent/PT1857547T/en unknown
- 2003-08-05 ES ES06027129T patent/ES2665274T5/en not_active Expired - Lifetime
- 2003-08-05 TR TR2018/16291T patent/TR201816291T4/en unknown
- 2003-08-05 KR KR1020127005474A patent/KR20120029002A/en not_active Application Discontinuation
- 2003-08-05 PT PT100122639T patent/PT2258847T/en unknown
- 2003-08-05 TR TR2017/08347T patent/TR201708347T4/en unknown
- 2003-08-05 PT PT17160954T patent/PT3222724T/en unknown
- 2003-08-05 ES ES10012263T patent/ES2627779T5/en not_active Expired - Lifetime
- 2003-08-05 JP JP2004526885A patent/JP4705370B2/en not_active Expired - Lifetime
- 2003-08-05 HU HUE06027129A patent/HUE038749T2/en unknown
Also Published As
Publication number | Publication date |
---|---|
TR201816291T4 (en) | 2018-11-21 |
JP2006500014A (en) | 2006-01-05 |
HUE039866T2 (en) | 2019-02-28 |
HUE038749T2 (en) | 2018-11-28 |
ES2665274T5 (en) | 2021-06-30 |
PT3222724T (en) | 2018-12-17 |
ES2665274T3 (en) | 2018-04-25 |
PT2258847T (en) | 2017-06-22 |
ES2627779T3 (en) | 2017-07-31 |
SI1527176T1 (en) | 2007-06-30 |
JP4705370B2 (en) | 2011-06-22 |
ES2695050T3 (en) | 2018-12-28 |
ES2627779T5 (en) | 2021-05-04 |
KR20120029002A (en) | 2012-03-23 |
HUE032289T2 (en) | 2017-09-28 |
PT1857547T (en) | 2018-02-08 |
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