TR201310828A2 - Antiseptic and antiinflammatory non alcoholic formulati̇ons - Google Patents
Antiseptic and antiinflammatory non alcoholic formulati̇ons Download PDFInfo
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- TR201310828A2 TR201310828A2 TR2013/10828A TR201310828A TR201310828A2 TR 201310828 A2 TR201310828 A2 TR 201310828A2 TR 2013/10828 A TR2013/10828 A TR 2013/10828A TR 201310828 A TR201310828 A TR 201310828A TR 201310828 A2 TR201310828 A2 TR 201310828A2
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- 230000003110 anti-inflammatory effect Effects 0.000 title claims abstract description 16
- 230000002421 anti-septic effect Effects 0.000 title claims abstract description 12
- 230000001476 alcoholic effect Effects 0.000 title description 2
- 239000002324 mouth wash Substances 0.000 claims abstract description 13
- 239000000203 mixture Substances 0.000 claims abstract description 9
- 229940051866 mouthwash Drugs 0.000 claims abstract description 9
- CNBGNNVCVSKAQZ-UHFFFAOYSA-N benzydamine Chemical compound C12=CC=CC=C2C(OCCCN(C)C)=NN1CC1=CC=CC=C1 CNBGNNVCVSKAQZ-UHFFFAOYSA-N 0.000 claims description 19
- 230000000844 anti-bacterial effect Effects 0.000 claims description 12
- 239000002253 acid Substances 0.000 claims description 10
- 229960000333 benzydamine Drugs 0.000 claims description 9
- 150000001875 compounds Chemical class 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 6
- 235000006679 Mentha X verticillata Nutrition 0.000 claims description 5
- 235000002899 Mentha suaveolens Nutrition 0.000 claims description 5
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims description 5
- 230000000843 anti-fungal effect Effects 0.000 claims description 5
- 229940121375 antifungal agent Drugs 0.000 claims description 5
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
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- 239000000243 solution Substances 0.000 claims description 3
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims description 2
- 244000166124 Eucalyptus globulus Species 0.000 claims description 2
- 239000004098 Tetracycline Substances 0.000 claims description 2
- 229940088710 antibiotic agent Drugs 0.000 claims description 2
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- 241000220225 Malus Species 0.000 claims 4
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- 229910003460 diamond Inorganic materials 0.000 claims 2
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- 239000004094 surface-active agent Substances 0.000 claims 2
- DTOUUUZOYKYHEP-UHFFFAOYSA-N 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine Chemical compound CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 DTOUUUZOYKYHEP-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
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- 235000021311 artificial sweeteners Nutrition 0.000 claims 1
- 210000000941 bile Anatomy 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 239000003995 emulsifying agent Substances 0.000 claims 1
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- 239000000194 fatty acid Substances 0.000 claims 1
- 235000015203 fruit juice Nutrition 0.000 claims 1
- 229960004867 hexetidine Drugs 0.000 claims 1
- 239000003120 macrolide antibiotic agent Chemical group 0.000 claims 1
- 238000005498 polishing Methods 0.000 claims 1
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- 239000004480 active ingredient Substances 0.000 abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 6
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- 229940127557 pharmaceutical product Drugs 0.000 abstract description 6
- 238000009472 formulation Methods 0.000 abstract description 4
- 229940041678 oral spray Drugs 0.000 abstract description 3
- 239000000668 oral spray Substances 0.000 abstract description 3
- HNNIWKQLJSNAEQ-UHFFFAOYSA-N Benzydamine hydrochloride Chemical compound Cl.C12=CC=CC=C2C(OCCCN(C)C)=NN1CC1=CC=CC=C1 HNNIWKQLJSNAEQ-UHFFFAOYSA-N 0.000 abstract description 2
- 244000246386 Mentha pulegium Species 0.000 abstract description 2
- 235000016257 Mentha pulegium Nutrition 0.000 abstract description 2
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- 229960001689 benzydamine hydrochloride Drugs 0.000 abstract description 2
- 235000001050 hortel pimenta Nutrition 0.000 abstract description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 abstract 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 abstract 1
- 235000019568 aromas Nutrition 0.000 abstract 1
- 229940041616 menthol Drugs 0.000 abstract 1
- 210000000214 mouth Anatomy 0.000 abstract 1
- RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000000126 substance Substances 0.000 description 14
- 239000000686 essence Substances 0.000 description 8
- 206010061218 Inflammation Diseases 0.000 description 7
- 230000004054 inflammatory process Effects 0.000 description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 238000011282 treatment Methods 0.000 description 6
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- 239000013543 active substance Substances 0.000 description 4
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- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
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- 150000004683 dihydrates Chemical class 0.000 description 2
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- 150000002148 esters Chemical class 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
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- 238000002636 symptomatic treatment Methods 0.000 description 2
- 108010011485 Aspartame Proteins 0.000 description 1
- 206010003497 Asphyxia Diseases 0.000 description 1
- ZETHHMPKDUSZQQ-UHFFFAOYSA-N Betulafolienepentol Natural products C1C=C(C)CCC(C(C)CCC=C(C)C)C2C(OC)OC(OC)C2=C1 ZETHHMPKDUSZQQ-UHFFFAOYSA-N 0.000 description 1
- 206010006784 Burning sensation Diseases 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 208000002064 Dental Plaque Diseases 0.000 description 1
- 208000005232 Glossitis Diseases 0.000 description 1
- 206010026749 Mania Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
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- 201000007100 Pharyngitis Diseases 0.000 description 1
- 235000004443 Ricinus communis Nutrition 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- PCSMJKASWLYICJ-UHFFFAOYSA-N Succinic aldehyde Chemical compound O=CCCC=O PCSMJKASWLYICJ-UHFFFAOYSA-N 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 235000013334 alcoholic beverage Nutrition 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000029936 alkylation Effects 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
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- 230000000692 anti-sense effect Effects 0.000 description 1
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- 239000000605 aspartame Substances 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
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- HEOKFDGOFROELJ-UHFFFAOYSA-N diacetal Natural products COc1ccc(C=C/c2cc(O)cc(OC3OC(COC(=O)c4cc(O)c(O)c(O)c4)C(O)C(O)C3O)c2)cc1O HEOKFDGOFROELJ-UHFFFAOYSA-N 0.000 description 1
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- 238000002372 labelling Methods 0.000 description 1
- 239000004922 lacquer Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
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- 210000004379 membrane Anatomy 0.000 description 1
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- 239000008363 phosphate buffer Substances 0.000 description 1
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- 206010044008 tonsillitis Diseases 0.000 description 1
- XPFJYKARVSSRHE-UHFFFAOYSA-K trisodium;2-hydroxypropane-1,2,3-tricarboxylate;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound [Na+].[Na+].[Na+].OC(=O)CC(O)(C(O)=O)CC(O)=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O XPFJYKARVSSRHE-UHFFFAOYSA-K 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
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- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
Bu buluş, nane esansı veya mentol aromalarını içeren ancak alkol içermeyen, alkol içeren formülasyonlara göre daha stabil, pH değeri 3,0-7,0 aralığında, klorheksidin diglukonat ve benzidamin hidroklorür etken maddelerinin kombine olarak kullanıldığı farmasötik bir ürün sağlamaktadır. Anılan ürün gargara, oral sprey, ağız çalkalama suyu tipinde ağız boşluğu, diş ve diş eti, boğaz antiseptiği ve/veya antienflamatuvarı özelliğinde kullanılmaktadır.The present invention provides a pharmaceutical product comprising chlorhexidine digluconate and benzydamine hydrochloride active ingredients in a pH range of 3.0-7.0, which is more stable than alcohol-containing formulations containing peppermint essence or menthol aromas but without alcohol. Said product is used as mouthwash, oral spray, mouthwash type oral cavity, teeth and gums, throat antiseptic and / or anti-inflammatory.
Description
TAHIFHAHE .hLI'EDL içERIHE'FEH AHTIEEFTIH. "Ii'E MTIEHFLMATWAH FÜRIIIÜLA-ETÜHLAR Bu bulus. gargara. öral sprey. agiz salkalama suyu tipinde agiz bbslugui dis ve dis eti. baga: antiseptigi veiveya antientlamatuvan özelligindeki tarmasötik üninler ile ilgilidir. TAHIFHAHE .hLI'EDL CONTAINHE'FEH AHTIEEFTIH. "II'E MTIEHFLMATWAH FÜRIIIÜLA-ETÜHLAR This is invention. mouthwash. oral spray. mouthwash type mouth bbslugui teeth and gums. Baga: It is related to pharmaceutical products with antiseptic and anti-inflammatory properties.
Günümüzde örai hijyenin saglanmasi. enfeksivizinlarin önlenmesi .I' tedavisi ve agrili agiz ve bogaz rahatsialiklarinin geçici ölarak rahatlatilmasi için sek sayida gargarai öral sprev. agiz galkalama suyu tipinde agi: bbslugui dis ve dis eti. baga: antiseptigi lii veiveya antienflamatuvan öaeil'igindeki farrnasötik önînler tieari ölarak bulunmaktadir. Ensuring traditional hygiene today. prevention of infectious .I' treatment and pain Numerous mouthwashes for temporary relief of mouth and throat discomfort oral spray. mouthwash type agi: bbslugui teeth and gums. bag: antiseptic Pharmaceutical drugs in the form of lii and or anti-inflammatory drugs are found by measuring.
Bu ön] nlerde genellikle antibakteriyeliantifungaliantiviral ölarak klibd'ieksid'in diglukdinat; antientlamatuvar elarakda benzidamin hidrbklbrür kullanilmaktadir. These preliminaries are usually antibacterial, antifungal, antiviral, and klibd'ieksid's diglukdinate; benzydamine hydrochloride is used in anti-inflammatory drugs.
Klditteksidin diglukdriati l'ien'i gram-gibiitif hem de gram-negatif bakteriler üzerinde genis spektrumlu antimikrbb'ival aktiviteve sahib kimyasal bir antiseptittir. Hlditteksidin diglukdnat bakterilerin l'iöere zarinin islevinin bbzulmasina neden ölarak. agiz içindeki bakterilerin gelisimini önler veya öldünIir- Plak ve dis eti iltihabinin tedavisinde en etkili antiseplittir. Ayrica antiviral etkisi de arastirmalarda saptanmistir. Benaidamin hidrbklnrür ise agiz ve bbgazda meydana gelen agrili ve iltihabi durumlar üzerinde etkili nbn-stenziidal antientlamatuar iNEAID) grubu bir etken maddedir. Bunlarin 'yani sira bir sekendet etki ölarak benaidamin l'iidrbklcirürün antibaktetiyel ve antifurigal etkinligi semptematik tedavi saglamaktadir. Cldittexidine diglukdriati l'ien is effective on both gram-like and gram-negative bacteria. It is a chemical antiseptic with broad spectrum antimicrobial activity. Hldittexidine Dilludnate bacteria die, causing disruption of the membrane's function. in the mouth Prevents or kills the growth of bacteria - Most effective in the treatment of plaque and gingivitis it is antiseptic. In addition, its antiviral effect has been found in studies. Benaidamine hydrbklnrür, on the other hand, is effective on painful and inflammatory conditions in the mouth and bbgas. nbn-stenziidal anti-inflammatory iNEAID) group is an active substance. Of these, besides a Antibacterial and antifurigal efficacy of benaidamin l'iidrbklcirür by killing the secondary effect provides symptomatic treatment.
JIIII Hlditteksidin diglukdnat ve benzidamin l'iidrbkldrür kdinbinasvbnunu içeren ürünler asagida belirtilen durumlarda kullanilmaktadir: i agiz hijyeninin saglanmasi: i dis Çevresi ve 'yakini ile ilgili hastaliklar: i çesitli dis eti iltihaplarini ri igingivitji giderilmesi ve önlenmesi; i dis plaklan ölusumunun önlenmesi; i dis çekimi ve dis tedavilerinde tedaviye yardirnçi dlarak: i agiz içi enfekstyenlari: i agiz içi yüzeyinin ilühaplanmasi: i bbgaz agrisi: i bademcik iltihabi: i dil iltihabi: i söluk bdrusu iltihabi: i agiz bölgesindeki dçerasyenlardan sönra.' i kemeterapi. radyçlerapi veya diger nedenlerden kaynaklanan agiz içi yüzeyi iltihaplari: i agrili agiz ve bogaz rahatsizliklarini ri geçidi çilarak rahatlatilmasi {dis çevresi ye bölgesindeki dçerasydnlar yb. durumlar): i farenjit; Gargara. çiral sprey. agiz çalkalama suyu tipinde agiz bi:islugui dis ve dis eti. bbgaz antisepligi yei'ireya antienflamatuyari özelligindeki famiasötik ürünlerde. etken maddelerin yani sira ferahlatiçi etkisinden ötürü nane esansi ye mental arerriialari kullanilmaktadir. Bu arörrialarin suda çözünürlügü çildukça az dldugu için arcirrialarin ürün içerisinde çözünürlügünü arttirrriak ve ürünün üretimi sönrasi faz ayrisrnasi ya da çökrrieyi önlemek amaciyla alkdl yardirnbi çözücü çilarak kullanilmaktadir. Alkçl. ayni zamanda bu aramalarin sagladigi ferahlatiçi etkiyi de arttim'iaktadir. .Hinçak ferrnülasyenda bulunan alkel agizda yanma hissine sebebiyet vermekte, rriukdzadaki süreli kullanirri ise agiz kökusuna ve dis reriginde degisiklige neden çilmaktadir. Özellikle agiz çalkalama sularinda %Eü'nin üzerindeki alkçil könsanlrasydnu. epitel dekelmani. keralinzi rnukezal ülserasyieini dis eti iltihabi. petesi ye agriya da neden çilmaktadir. Çalismalar. agiz çalkalama sularinin içerdigi alkel içerigi ile çiral kanser gelisiminin dogrudan iliskisi dldugunu göstermektedir. Delayisiyla alkel içerikli agiz çalkalama sularinin uzun süreli kullanirrii kesinlikleönerilrneriiektedir. Products containing JIIII Hldittexidine diglukdnate and benzydamine l'iidrbkldrür kdinbinas etc. It is used in the following situations: i Ensuring oral hygiene: Diseases related to the external environment and relatives: Removal and prevention of various gingivitis and gingivitis; i prevention of dental plaque death; By helping the treatment in tooth extraction and dental treatments: i oral infections: i inflammation of the intraoral surface: i bbgas pain: i tonsillitis: i tongue inflammation: Inflammation of suffocation: i after the decaesians in the mouth area.' i chemotherapy. intraoral surface caused by radiotherapy or other causes inflammations: Relief of painful mouth and throat ailments by squeezing the RI dçerasydn in the region yb. situations): i pharyngitis; Mouthwash. chiral spray. mouthwash type mouth bi:islugui tooth and gum. bbgas antisepligi yei'ire or in pharmaceutical products with anti-inflammatory properties. active Peppermint essential oil and mental arrhythmias due to its refreshing effect, as well as substances is used. Since the water solubility of these aurrias is extremely low, by increasing its solubility in the product and by phase separation after production of the product or In order to prevent precipitation, alkaline yardirnbi solvent is used by removing it. Alk. same At the same time, I also increase the refreshing effect of these calls. .Hinchak The alkali in ferrinulasian causes a burning sensation in the mouth, If it is used for a long time, it causes a change in the root of the mouth and tooth color. Especially in mouth rinse waters, it was alkaline consonant above %Eu. epithelium decalmani Keralinzi rnucesal ulcerasyieini gingivitis. Petesi and pain or why is going crazy. Studies. Chiral cancer development with the alkaline content of mouth rinses shows that there is no direct relationship. Mouthwash with alkaline content Long-term use of water is strongly recommended.
Teknigin bilinen uygulamalarindan. WÜEÜÜEJÜEIIEET sayili uluslararasi patent basvurusunda. alkdl içermeyen klbrl'ieksidin ferrriülasyenlari açiklanmaktadir. ..Hinçak bu bulusta klcirheksidin diglukdnat ya da klcirheksidin diasetaL benzidamin HÜI ile kön1 bine clarak degil tek basina kullanilmistir. Bulus enflamasycinu tedavi edebilecek bir antienflamatuvai bilesik içsnnemektedir. Ayrica arcima clarak ahududu kullanilmistir ve suda çözünürlügü cek az clan nane esansi ya da mental aramasi bulunmamakta, dcilayisi ile kullanildigi zaman ferahlik vermemektedir. One of the known applications of the technique. International patent numbered WÜEÜEJÜEIIEET in your application. Alkdl-free klbrl'iexidine ferrules are disclosed. ..Hinchak this in the invention, klcirhexidine diglukdnat or klcirhexidin diacetaL benzydamine HÜI and kön1 bin It is used alone, not as a clarifier. The invention is a drug that can treat inflammation. It does not contain anti-inflammatory compounds. In addition, raspberry was used by clarifying arcima and There is no mint essence or mental search that is low in water solubility, It does not give relief when used with its lacquer.
WÜEÜMÜdöSTE sayili uluslararasi patent basvurusunda. agiz bdslugu enfeksiycinlarinin ve mukcial enfeksiycinlarin tedavisinde. en az bir antimikrölziiyal etken madde ile en az bir esansiyel yag ve alkcilsüa bir tasiyici sistem içeren farmasöitik bilesim açiklanmaktadir. Bu tasiyici sistemin izditcnik ve cirta hipeitönik bir sistem cldugu belirlilmektedir. Ancak bu bulus. enfekte cilt ve mukczal membran vakalannda yalnizça antimikrd-biyal etkili etken madde kullanimini bildirmekte. enfeksiyizin ile birlikte gelisen enflarnasydnu tedavi edebileçek antientlamatuvai bir bilesik {Ür. Benzidamin HCI) içem'iemektedir- Ddlavisi ile enfekte bölgenin iyilesmesini hizlandirabilecek önemli bir etmenden ydksundu r. In the international patent application numbered WÜEÜMÜdöSTE. mouth bdslu in the treatment of infectious and mucous infections. at least one antimicrobial pharmaceutical product containing the active ingredient and at least one essential oil and an alkylene carrier system composition is described. This carrier system is an izditcnik and cirta is a hypeitonic system. cld is determined. But this is the invention. in cases of infected skin and mucous membranes reports only the use of antimicrobial-active active substances. with your infectious An anti-inflammatory compound that can treat developing inflammation {Dr. benzydamine HCI) - important factors that can accelerate the healing of the infected area with Ddlavisi was ydksunn of one factor.
WÜE-Düêli'Ü-#ttüü sayili uluslar arasi patent basvurusunda. alkcl içermeyen nötr antimikrnbiyal sölüsycn içeren tek kullanimlik steril pamuk açiklamaktadir. Ancak bu bulus da enflan'iiasydnu tedavi edebilecek bir antienflamatuvar bilesik {Ür. Benzidamin HCI) içem'iemektedir- Ddlavisi ile enfekte bölgenin iyilesmesini hizlandirabilecek önemli bir etmenden ydksundu r. WÜE-Düêli'Ü-#ttüü in the international patent application. neutral without alkcl Discloses a single-use sterile cotton containing antimicrobial diluent. However, this The invention also includes an anti-inflammatory compound that can treat inflammation {Dr. benzydamine HCI) - important factors that can accelerate the healing of the infected area with Ddlavisi was ydksunn of one factor.
WÜE-Düöiüöüîüt sayili uluslar arasi patent basvurusunda. bir kindlin türevi ile bir antiseptit içeren fermülasydn açiklanmalttadir. Bu fcrmülasydna ilave clarak analjezik. antienflamatuvar. antiviral. antibaklenyel. antitungal veya antinecplastik bir diger etken maddenin de eklenebilecegi. antiseptigin aIkciI içerrrieyen bir cözeltide klcirI'ieksidin cildugu belirtilmistir. Ancak bu bulusta fcrmülasyiöna ilave clarak kullanilabilecek maddelerden biri clan antienflamatuvar maddenin antibakleriyel. antifungal ve Idkal anestezik etkisinden bahsedilrriemistir. Antienflamatuvar maddenin sekcinder bir etki clarak antibakteriyel. antitungal ve Ibkal anestezik özellikte clmasi iltihapli bölgenin hem iyilesmesinin hizlanmasi ve hem de semptcimalik tedavi için önemli bir özellikür. farkli etkili etken maddeler {analje2ik. antienflamatuvari antiviral. antibaktei'iyel. antitungal veya antinecplastik. vs..} ile birlikte kullanilabild'iiji bildirilmis. ddlayisi ile hastanin bir cek etken madde almasi clasi hale gelmistir. üysaki hastanin aldigi farmakdlbjik atk'ili stkai'i maddelerin sayisinin artmasi. her bir atkai'i maddanin ayri ayri i:iiari atkilai'ii'iin gÜzIanmasina sabap blabilaibaktir. Mevcut bulusta, atkai'i madda sayisi tedavi için hastaya en az sayida alkan madda vararak hastanin an fazla branda fayda gürmssi ua blasi alkan madda yan stkilariri azaltilmasi amaçlanmistir. Bu kapsamda iyani bulus. antisapl'ikiaritianllamatuirari'lbkal anastazik atk'rsri an iyi yansitabilabsk klbrl'isksidin diglukdinat 'iia banzidam'in hidrbklarür stkan maddalari ila fibrmi'ila aidilamk üstün hala gatii'ilmistir. In the international patent application no. one with a kindlin derivative The antiseptic containing fermulus is described. In addition to this formulation, analgesic clarification. anti-inflammatory. antiviral. antibacterial another antitungal or antinecplastic agent item can be added. chlorinated in a solution that does not contain alkaline antiseptic skin is indicated. However, in this invention, it can be used in addition to the formulation. One of the ingredients is the anti-inflammatory substance that is antibacterial. antifungal and Idkal its anesthetic effect is mentioned. A secondary effect of the anti-inflammatory substance clark antibacterial. Antitungal and Ibkal anesthetic properties, inflammation of the inflamed area It is an important feature for both acceleration of recovery and symptomatic treatment. different effective active ingredients {analge2ik. anti-inflammatory antiviral. antibacterial antitungal or antinecplastic. etc..} It has been reported that it can be used together. with her tongue It has become classic for the patient to take a check active substance. the patient received The increase in the number of pharmacdlbjik-related stkai'i substances. each atkai item separately i:iiari atkilai'ii'in güzlanmasina sabap blabilaibaktir. In the present invention, the number of atkai'i items For the treatment, the patient can benefit from the most tarpaulin by reaching the patient with the least number of alkane substances. It is aimed to reduce the side effects of gürmsi ua blasi alkane. In this context good find. antisapl'ikiaritianllamatuirari'lbkal anastatic atk'rsri an reflect well klbrl'isksidin diglukdinat 'iia banzidam's hydrbklarure stkan substances ila fibrmi'ila aidilamk the superior is still gatii'ilm.
Klarl'iaksidiri diglukdiriatin antisapl'ik üzalligi. banzidam'in hidrbklbrürün isa antibaklariii'al. antiiungal. amianflamatwar ua lbkal anastszik üzalligi ila tedavi edici amaçla kullanildigi va bu ikistkan maddayi ibaran farmasdtik üninlar inbaIai'idigi zaman hapsinda alkblün iyardimci çözücü] blarak fbrrnülasybnda bulundugu gürüImaktad'ir. The antiscapularity of diglukdiriatin with klarl axilla. banzidam's hydrbklbrür jesus antibaklariii'al. antiungal amianflamatwar ua lbkal anastszik uzalligi therapeutic when it is used for this purpose and when it contains this substance It is seen that he is in the form of alcohol by leaving the co-solvent] in prison.
Bundan dblay'i. alkiblsi'iz klbrhiaksid'in diglukdriat fdrmülasydnlari bulunmakta. ancak klbrl'iiaksidin diglukdinat - banzidam'in hidrcikldriîir alkan maddalarini kdi'nbina blarak ibarari alkblsi'iz fbrmülasybrilar bulunmamaktadir. Aruba çözünürlük sababi ila nana ssai'iswaya manlial ardi'riiasi alkblsüzfbrmülasydnlarda kullai'iilamamakladir. antisapliic bir maddanin antianflamatuiilar etkili bir madda ila kdi'nbina blaiak kullanildigi ua fdrmülda 'yar alai'i antiariflamatuuar atkili maddanin sakbndai &tki blarak antibaklariyall'antifungal 'ula Ibkal anastszik özallikta bldugu. alkbl ibam'iayan. agiz bbslugunda kullanildigi zamai'i içeriginde: bulunan nana asansi ya da manldl ardi'riiasi ila fsrahlama hissi varan 'iia fizikbk'imyasal blaiak stabil bir farmasütik ünin hanüz gslistirilrnamistir. dlay from this. alkiblsi'iz klbrhiaksid has diglukdriat fdrmülasydnlari. however klbrl'iiaksidin diglukdinat - by leaving banzidam's hidrcikldriîir alkane substances kdi'nbina There are no ibarari alkblsi'iz fbrmülasybris. Aruba resolution sababi to nana ssai'iswaya manlial ardi'riiasi cannot be used in alkblsuzfbrmullasydn. where an antisense substance is used with an anti-inflammatory substance and kdi'nbina blaiak ua fdrmülda 'yar alai'i anti-inflammatory antibaklariall'antifungal 'ula Ibkal anastsic essence bldugu. alkbl ibam'iayan. mouth nana asansi or manldl ardi'riiasi found in zamai'i content: used in bbslugu 'iia physicbk' chemical blaiak with a feeling of relief from a still a stable pharmaceutical reputation it has not been specified.
Bulus un Amaci Elu bulusun amaci. nana ssai'isi ua manldl ardiTiialarini Ibarisi'i anbak alkdil Ibsn'i'isyan. alkbl Ibsrari f-brmülasydrilara göre daha stabil. antisaiplir madda blarak klbd'isksidi'i diglukdriatin va antianflamatu'iiar stk'inin yani sira antibaktariyalianfungali'ldkal anastazik atk'rs'a sahib banzidam'in hidrbkldrürün kdi'ribina blarak kullanildigi bir ünin galistirmaktir. Purpose of the Invention Elu find the purpose. nana ssai'isi ua manldl ardiTiialarini Ibarisi'i anbak alkdil Ibsn'i'isyan. It is more stable than alkbl Ibsrari f-brmülasydris. antisaiplir madda barak klbd'isksidi'i diglukdriatin va antianflamatu'iiar stk as well as antibaktariyalianfungali'ldkal of a reputation in which banzidam, who has anastasic atk'rs, is used by killing hydroxyl kdi'ribina is to improve.
Bulus un giklamasi Bu bulus ile nane esansi ve mental ardmaIanni iceren ancak aIkcI isem'ieyen. alkcl iceren fcrmülasydnlara güre daha stabil. pH degeri .lü-II] araliginda. tercihen 4,5-&5 araliginda. antiseplic madde clarak klcrlieksid'i'i diglukdnatin ve antienflamatuii'ar etkinin yani sira antibakleriyeli'antilungaliilckal anestezik etkiye sahip benzidamin l'iidrcklcirürün kdmbine claiak kullanildigi slabiI bir ünün gelistirilmistir. The click of the invention With this invention, it contains mint essence and mental succession, but has a clear name. alkcl It is more stable than the formulas containing it. The pH value is in the range of .lu-II]. preferably 4.5-&5 in the range. klcrlieksid'i'i diglukdnatin and antiinflammatories by clarifying antiseplic substance benzydamine, which has antibacterial and antiilungaliilckal anesthetic effect as well as l'iidrcklcirürü kdmbine claiak has been used to develop a stable reputation.
Alkcllü ve alkclsüz clmak üzere iki ayri fcrmülasydn gelistirilmis ve stabilite iIe pH degerleri kryaslar'imistir. Bu degerler asagida 'yer alan Table 1 ve Tabii: 2'de verilmektedir. Burada güriülen alkcllü fcrrnülasydn etancil icen'nekte. alkclsü: fcrrnülasyidn ise etancil icen'rien'iektedir. Alkclsüz fcrmülasydnda alkcl yerine yardimci cüzüci'i claiak crdpilen glikdl kullanilmistir. Her iki fcrrnülasydndan ikiser seri üretim i:iiaiailarak 41] ”G 'tiiiTEi bagil nem kdisLiIunda IE ay bcyunca slabilitelei'i ialenmistir. Alkcl iceren fcrmülasy'dna bakildigi zaman 1iiilddrheksidin diglukdnat milrtari E. aya gelindiginde ciddi cranda azalmistir; ancak alkcl icen'ries'eri fcrmülasydn incelendiginde fcrrnülasyidnun daha stabil bir fcrmülasydn cldugunu güzlenmistir. Fdimülasycnlarin pH'Iari incelendiginde; alkcllü fcrmülasydnun pH'i ?,Ü'den 'yüksek iken alkclsüz fcrrnülasyidnun pH'i daha düsük clmasi icin {3.Ü-?.ü]i tampcin cüaelliler araciligi ile ayarlanmistir. pH degerinin ?,Ü'den düsük clmasi klcrlieksidin diglukdnat icin bir avantajdir. Alkali crtarrida l'iidiclia clabilen bu etken maddenin stabilitesinin hafif asidik crtarnda saglanabildigi literatürde bildirilmistir. Ancak. klcrl'ieksidin diglukdnat ile benzidamin l'iiidicklciiürün kd-mbine cldugu bu 'yeni bulusta benzidamin l'iidrcklcrür etken maddesinin de slabilitesi saglanmis ve her iki etken maddenin kcmbine I'iialde stabil cldugu bir fcrrnülasyidn elde edilmistir- Benzidamin l'iidrbkldiürün acik kimyasal parçalanarak Britanya farrnakdnesinde 'yapisi bildirilen -[Elritisl'i Pharmaccpceia} impürite G mclekülü clusabilmektedii. de'iiilasycnun cH degerinin hatif asidik cHta clmasi {3.ü-?.ü]- benzidamin l'iiidicklciür etken maddesinin stabilite süresince milirtar tayini degederinindegismemesini ve benzidamin i'iiidrckldrüre ail salsizlik clan impürite E`nin clusmamasini saglamistir. It has been developed from two separate formulas, with and without alkylation, and pH with stability. their values are kryaslar. These values are in Table 1 and Of course: 2 below. are given. Here, the alcoholic beverage fcrrnülasydn etancil icen'nekte. alcohol: fcrrnülasyidn is etancil icen'rien. Auxiliary substitute for alcohol when used without alcohol Cüzüci claiak crdpilen glikdl is used. Two serial production from both refrigeration i:iiaiailarak 41] ”G 'tiiiTEi relative humidity kdisLiIl IE month bc slabilitelei'i has been added. alkcl When looking at fcrmülasy containing 1iiilddrheksidin diglukdnat milrtari E. aya when it arrived, it was severely reduced; but when examining alkcl icen'ries fcrmülasydn It is believed that fcrrnulasyidn is a more stable fcrmulusidn. Physicians When their pH is examined; When the pH of the alkylated formula is higher than ?,Ü, it is non-alkaline In order for fcrrnulasyid to have a lower pH, {3.Ü-?.ü]i tampcin is used by cuaelli. is set. A pH value lower than ? is an advantage. The stability of this active ingredient, which can be alkaline crystallida l'iidiclia, is slightly acidic. It has been reported in the literature that it can be provided in However. with klcrl'iexidin diglukdnat benzydamin l'iiidicklcrür this 'new invention benzydamin l'iidrcklcrür kd-mbine cldugu The scalability of the active ingredient was also ensured and the combination of both active ingredients was a fcrrnulasyidn, which is stable fragmented and 'structured' in the British pharmacology -[Elritisl'i Pharmaccpceia} impurity G molecule could be clustered. de'iiilasycnun cH value slightly acidic cH clmasi {3.ü-?.ü]- benzydamine 1'iiidicklciure militar during the stability of the active ingredient the determination of the value does not change and benzydamine i'iiidrckldrure related impurity He made sure that E didn't clump.
Table 1. Alkellü fermülassien stabilite iierileri. Table 1. Alkaline fermulassian stability contents.
Baslangiç 6. .Ay Baslangiç 6. .Ay Baslangiç 6. .Ay Sari 1 1I}ü.5 'IMJJI'Q '95.9 EGE!] ?'.ü-Il 5.?'4 Table 2. Alkelsüa fermülassien stabilite verileri. Beginning 6th .Month Beginning 6th .Month Beginning 6th .Month Yellow 1 1I}ü.5 'IMJJI'Q '95.9 EGE!] ?'.ü-Il 5.?'4 Table 2. Alkelsua fermulassien stability data.
Baslangiç 6. .Mr Baslangiç 6. .Mr Baslangiç 5. !iy Sekil 1. Eenaidan'iin Hidröklerür [British Phannaisöpeeia .Etiö'ýîi Alkölsüz fermülassrenun pH'i igrenik tampenlar disindaki yardimei maddeler ile 3.ü-T.ü arasina asiadanabileeegi gibi. bu aralikta çalisan sitrik asit-tesral tampizir'iu. sitrik asit- sedyum sitrat tampizinu. asetik asit-sedsrum asetat tampenu. fösfat tampenu gibi pH'i biyeusiumlu istenilen aralikta sabitlemesie yarayan ile de sabitlenebil mekted ir. iyenik maddeler EliLi tarmasötik ürünün pH degerinin !lü-?ll tercihen :LS-5.5 araliginda elmasi hem kleirheksidin diglukenatin beaunarak d-klerizianilin iie benzeri beaunma ürünlerine dönüsmesini azaltmakta. hem de benaidan'iiniri beaunarak impürite 'B'ye dönüsmesini engellemektedir. Ayrica miktar tayinlerinin stabilite süresi beyunea daha yüksek çikmasi avantajini saglamaktadir. Delayisryla kembinasyenda bulunan her iki etken maddenin miktarinda degisim çek az gödemlenmekte. daha stabil bir fermülasiren elde edilmekte iie bitmis ününün raf ömrü uzatilmaktadir. Beginning 6. .Mr Beginning 6. .Mr Beginning 5. !good Figure 1. Hydroclerosis of Eenaidan [British Phannaisöpeeia .Etiö'ýîi The pH of alcohol-free fermulassren is 3.ü-T.ü with auxiliary substances other than igreek tampons like he can hang in between. citric acid-tesral tampizir'iu working in this range. citric acid- sodium citrate tampizinu. acetic acid-sedsrum acetate tampenu. pH like phosphate buffer in the desired range with biyeusium also with fixing it can be fixed. new materials The pH value of the EliLi pharmaceutical product is preferably between :LS-5.5. By labeling cleirhexidine diglukenatin, it has been assigned to similar products such as d-clerzianiline. reduces its conversion. as well as converting benaidan into impurity 'B' by declaring it hinders. In addition, the stability period of the assays is higher in the brain. provides the advantage. Delayisryla both factors found in the chembinasian Change in the amount of the item is paid less than the check. achieve a more stable fermulasiren The shelf life of the finished product is extended.
Bulusun açiklamasindan görülecegi üzere. alköllü termülassrenda bulunan alkeilün yarattigi istenmeyen etkiler bertaraf edileeiegi gibi. ayni zamanda alkeil kullaniminin elimine edilmeai ile daha atabil. istenilen aralikta DH degerine aahip bir femiülaayen elde edilmektedir. As will be seen from the description of the invention. alkeilun found in alcoholic thermulassrene as the undesirable effects it creates can be eliminated. At the same time, the use of alkeil more able to be eliminated with elimination. a femiulae with a DH value in the desired range is obtained.
Agiz beslugu. dis ve dis. eti. baga.: amiaeptigi vel'u'esia antienflamatu-.iari ile li:ikal içeren famiaaütik ürünler: çözelti. emülaiy'en. aüapanaiyen. jel. krem. Dernat fermunda elalailir. Bu ürünler ealkalama ya da aürri'ie ydluyla degrudan iatenilen bölgeye uygulanabilir ya da uygulama için çesitli aygitlar [Daaineli ölçülü de: -aerciaDI-. mouth feeding. dis and dis. meat. baga.: amiaeptigi vel'u'esia antienflammatu-.iari with li:ikal Pharmaceutical products containing: solution. emulaiy'en. aapanaian gel. cream. dernat fermunda it can be handled. These products are delivered directly to the area of shipment through relief or aurri'ie can be applied or various devices for application [Also in regular measure: -aerciaDI-.
Dasmeaia eleülü de: -Dral sprey-`J kullanilabilmektedir. In Dasmeaia eleül: -Dral spray-`J can be used.
Bulus ken uau fermülassien örnekleri asagida yer almaktadir: MADDE aalaliii FeaiiIIJL iaihii HIDrl'iEl-tsidin diglu kena1 '1112 Eenzida min hidrDkIDrür '3.15 F'i:iliai:irl:iat El] &DCI F'rcipilan glik-::il 25.ÜI} Serbitcil 5.EIÜ SÜ kiailea 'ELDE F'atant 1." matrisi I.'1III'I Hindi iri ::arisi I.'1III'I Nana aaanai 'ELDE Mani-::II arizimaai Ü.1I'.'I Sitrik aait mDnDhidial CLEIEE SÜd'fUI'I'I silral dihidrat CI. 17-'5 Örnek-2: MADDE IitDlFtliii FeaiiIUL iaihi HIDrl'iEI-isidin diglukena1 '3.12 Banzida min hidrizikIDrür '1115 F'Dliadrbat El] ELIIIÜ F'ricipilen glik-::il EEÜÜ Serbitcil i'.IIII'.'I SÜ kialea 'ELDE F'ataint U matrisi I.'ILIII'I Hindi iri E-EFIE-I I'ÇLIII'I l'ilana aaanai 'ELDE Mani-::II aramasi 'ELDE Sitrik aait mDnDhidial IELIJEIS SDdyLim 5ilra1 dihidrat Ü. lîi'E- Saf su 'y'JTL Bulus kenusu. vukaridaki örneklerle sinirlandirilan'iavaeagi gibi, fermülasvenda ver alan aktif ve inaktilîer degistirilebilebektir. Örnegin antiseptit çilarak klidrl'ieksidin, türev ve çesitli tuzlariniri vani sira bdrik asit, perherik asit, l'iiekzetidin. benzalkianvun'i klçirür. pdIivinilpireliddn ivat, l'iidrdjeri peroksit, ektenidin l'iidrdklnrür, benznik asit, serbik asit, incirganik sütlit. parabenler. trikldsan, setrimid ve tüm bu bahsedilen bilesiklerin türevleri ve tudari da %Ü,ü1 ila %11] arasinda kullanilabilecektir. Antient'lamatuvai çilarak benzidari'iiri, türev ve çesitli tuaarinin vani sira antienflarnatuvar özellikte ve sekidnder çilarak aritibakteriveliiantifungal va da li:ikal anesteiik etkiye sahip maddeler de {tetrasikliri va da makrn-Iid grubu antibivatikler, çesitli bilkisel ekstrelei va da bilkileriden izale edilen ddgal bilesiklerfl %031 ila %11] çiranmtla kullanilabilecektir. ?üzev aktif madde çilarak pdlidksietilen snibitan vag asidi esteri El] -[i:ii:iilisi:irbat lü) disinda baska ridri ivanik vüzegi.r aktif maddeler ifbaska pdlidksietilen sciibitan vag asidi esteri türevleri, pdlidksil hidrdjerie hint vagi türevleri, pdlidksietileniipdlidksipmpilen kepelimer türevleri, vs ] %ü,Ü1 ila %21] çiraniritla: esansivel vag çilarak nane esansinin vani sira ükaliptus esansi, Iirnçiri esansi, pdrtakal esansi vb. suda çüzünmeven meyve esanslari ve bilkisel esanslar %üüûüt ila %11] çiraniritla; ayrica ddgal mental va da mental aramalari da vine ayni çiranlarda fermülasvcinda ver alabilecektir. Farmülasvdnda vardimsi çiz'izüsü çilaiak alkçil verine kullanilan prapilen glitcil de vine %ÜDE ila %50 çiranirivda kullanilabilecektir. Fnm'iülasvdnu tatlandin'riak amaçivla serbitçil ve sükralciz verine gliserin, sedvum sakkai'in, aspartam. sndvum siklai'riat, nedhesperidin dihidrakalkcin vb. ddgal va da vapasi tatlandiriçilar %üýt ila %54] çiranirida kullanilabilecektir. Fnrri'iülasvbriun pH degerinin ayarlanmasi amaçivla sitrik asit- sedvum sitrat tampcinunun vani sira tampcin blusturma üzelligindelti siti'ik asit-Insfat tampenu. aselik asit-sddwm asetat tampcinu. fdsfat tampcinu ve benzeri pH'i sabitlemeve varavan bivauvumlu ivanik maddeler %Ü,ü1 ila “gülü çiranirivda fdrmülasynna ilave edilebileceklir.The inventive uau fermulassien samples are given below: ARTICLE APPLICATION HIDrl'iEl-tsidin diglu kena1 '1112 Eenzida min hydrDkIDrür '3.15 F'i:iliai:irl:iat El] &DCI F'rcipilan glik-::il 25.ÜI} Serbitcil 5.EIÜ SU kiailea 'ELDE F'atant 1." matrix I.'1III'I Turkey lark ::bee I.'1III'I Nana aaanai 'ELDE Mani-::II arizimaai Ü.1I'.'I Citric acid mDnDhidial CLEIEE Sud'fUI'I'I silral dihydrate CI. 17-'5 Example-2: ARTICLE IitDlFtliii FeaiiiUL HIDrl'iEI-isidin diglukena1 '3.12 Banzida min hydrizikIDrure '1115 F'Dliadrbat El] ELIIIÜ F'ricipilen glyc-::il EEUU Serbitcil i'.III'.'I SU kialea 'ELDE F'ataint U matrix I.'ILIII'I Turkey large E-EFIE-I I'CLIII l'ilana aaanai 'HOLD Mania-::II search for 'ACHIEVE Citric acid mDnDhidial IELIJEIS SDdyLim 5ilra1 dihydrate Ü. lii'E- Pure water 'y'JTL Invention kenus. give fermulasvenda, like the iavaeagi limited to the above examples field active and inactive can be changed. For example, by removing the antiseptic, klidrl'iexidine, derivative and various salts thereof, as well as hydric acid, perheric acid, 1-exetidine. destroys benzalkianvun. pdIivinilpireliddn ivat, l'idrdjeri peroxide, ectenidine l'idrdklnür, benznic acid, cerbic acid, inorganic milkite. parabens. trikldsan, cetrimide and derivatives of all these compounds and tudari can be used between %Ü,ü1 to 11%]. By chanting antient'lamatuvai Benzidari'iiri, derivatives and various tuaars, as well as anti-inflammatory and sequidnder There are also substances that have an antibacterial, antifungal or li:cal anesthetic effect. {tetracycline or makrn-Iid group antibiotics, from various medicinal extracts or compounds The isolated addgal compounds 031% to 11%] can be used with chert. ?home active by removing the substance, pdlidxyethylene snibitan vag acid ester E1] -[i:ii:ilisi:irbat lü) other than ridri ivanik vezegi.r active substances if other pdlidoxyethylene sciibitan vag acid ester derivatives, pdlidxyl hidrdjerie castor vagi derivatives, pdlidxyethyleneniipdlidxipmpilen kepelimer derivatives, vs ] %ü,Ü1 to 21%] çiraniritla: extracting essential oil, mint essential oil, as well as eucalyptus essence, Iirnçiri essence, pdrtakal essence, etc. water-soluble fruit essences and herbal essences %uüüüd to 11%] cheraniritla; also ddgal mental or mental calls will also be able to be received at the same vineyards in fermulasvcinda. In the pharmacy vardimish streak raspberry glitcil de vine %UDE to 50% It can be used in çiraniriv. Fnm'iülasvdnu tatlandin'riak for the purpose of serbitçil and sukralciz verine glycerin, sedvum sakkai'in, aspartame. sndvum siklai'riat, nedhesperidin dihydracallkcin etc. ddgal va da vapas sweeteners %ute to 54%] çiranirida can be used. Citric acid- sedvum citrate tampcinunu van as well as tampcin blusturma uzelligindelti siti'ic acid-Insfat tampen acelic acid-sddwm acetate tampcinu. fdsfat tampcinu and similar pH fixation and varavan bivauvum ivanic substances %Ü,ü1 to “rose çiranirivda It can be added to the formulation.
Claims (5)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2013/10828A TR201310828A2 (en) | 2013-09-13 | 2013-09-13 | Antiseptic and antiinflammatory non alcoholic formulati̇ons |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2013/10828A TR201310828A2 (en) | 2013-09-13 | 2013-09-13 | Antiseptic and antiinflammatory non alcoholic formulati̇ons |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201310828A2 true TR201310828A2 (en) | 2015-03-23 |
Family
ID=63834704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2013/10828A TR201310828A2 (en) | 2013-09-13 | 2013-09-13 | Antiseptic and antiinflammatory non alcoholic formulati̇ons |
Country Status (1)
| Country | Link |
|---|---|
| TR (1) | TR201310828A2 (en) |
-
2013
- 2013-09-13 TR TR2013/10828A patent/TR201310828A2/en unknown
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