TR201000687A1 - Effervescent formulations containing cefixime and clavulanic acid as active ingredient - Google Patents
Effervescent formulations containing cefixime and clavulanic acid as active ingredientInfo
- Publication number
- TR201000687A1 TR201000687A1 TR2010/00687A TR201000687A TR201000687A1 TR 201000687 A1 TR201000687 A1 TR 201000687A1 TR 2010/00687 A TR2010/00687 A TR 2010/00687A TR 201000687 A TR201000687 A TR 201000687A TR 201000687 A1 TR201000687 A1 TR 201000687A1
- Authority
- TR
- Turkey
- Prior art keywords
- forms
- clavulanic acid
- active ingredient
- formulations containing
- effervescent formulations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Mevcut buluş, dirençli enfeksiyon tedavisinde kullanılmak üzere, sefiksim ve klavulanik asit ve/veya bunların farmasötik kabul edilebilir tuzları, hidratları, enantiomerleri, rasematları, organik tuzları, inorganik tuzları, esterleri, polimorfları, kristal formları ve amorf formları ve/veya bunların kombinasyonlarını içeren efervesan farmasötik formülasyonlar ile ilgilidir. Ayrıca, aktif bileşenler su içinde çözülmek sureti ile taze halde hastaya verildiğinden, süspansiyon formlara göre raf ömürleri daha uzun, biyoyararlanımları daha yüksektir. Bu şekilde hazırlanan efervesan formülasyonların kullanımı, tablet ve kapsül formlara kıyasla özelikle yaşlı ve çocuklar gibi yutma zorluğu yaşayan hastalarda daha kolaydır.The present invention is an effervescent composition comprising cefixime and clavulanic acid and / or pharmaceutically acceptable salts, hydrates, enantiomers, racemates, organic salts, inorganic salts, esters, polymorphs, crystalline forms and / or amorphous forms thereof and / or combinations thereof for use in the treatment of resistant infection. pharmaceutical formulations. Furthermore, since the active ingredients are dissolved in water and delivered to the patient in fresh form, their shelf life is longer and their bioavailability is higher than the suspension forms. Effervescent formulations prepared in this way are easier to use than tablets and capsule forms, particularly in patients with difficulty in swallowing, such as the elderly and children.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TR2010/00687A TR201000687A1 (en) | 2010-01-29 | 2010-01-29 | Effervescent formulations containing cefixime and clavulanic acid as active ingredient |
PCT/TR2011/000033 WO2011093829A1 (en) | 2010-01-29 | 2011-01-28 | Effervescent formulations comprising cefixime and clavulanic acid as active agents |
EP11712063A EP2528586A1 (en) | 2010-01-29 | 2011-01-28 | Effervescent formulations comprising cefixime and clavulanic acid as active agents |
PCT/TR2011/000026 WO2011093822A1 (en) | 2010-01-29 | 2011-01-28 | Effervescent formulations comprising cefixime and clavulanic acid as active agents |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TR2010/00687A TR201000687A1 (en) | 2010-01-29 | 2010-01-29 | Effervescent formulations containing cefixime and clavulanic acid as active ingredient |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201000687A1 true TR201000687A1 (en) | 2011-08-22 |
Family
ID=43853203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2010/00687A TR201000687A1 (en) | 2010-01-29 | 2010-01-29 | Effervescent formulations containing cefixime and clavulanic acid as active ingredient |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP2528586A1 (en) |
TR (1) | TR201000687A1 (en) |
WO (2) | WO2011093822A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011142730A1 (en) * | 2010-05-14 | 2011-11-17 | Mahmut Bilgic | Pharmaceutical composition comprising cefixime and clavulanic acid derivative compound |
WO2011152806A1 (en) * | 2010-06-03 | 2011-12-08 | Mahmut Bilgic | Production method for the effervescent formulation comprising cephalosporin and potassium clavulanate |
WO2013109228A1 (en) * | 2012-01-18 | 2013-07-25 | Mahmut Bilgic | Formulations comprising cefixime as active agent |
WO2014126541A1 (en) * | 2013-02-14 | 2014-08-21 | Bilgiç Mahmut | Pharmaceutical compositions used in treating bacterial infections |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1508977A (en) | 1974-04-20 | 1978-04-26 | Beecham Group Ltd | Beta-lactam antibiotic from streptomyces clavuligerus |
US4409214A (en) | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical, Co., Ltd. | 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof |
AU5863894A (en) | 1993-01-22 | 1994-08-15 | Smithkline Beecham Plc | Pharmaceutical formulations comprising clavulanic acid alone or in combination with other beta-lactam antibiotics |
GB9408117D0 (en) | 1994-04-23 | 1994-06-15 | Smithkline Beecham Corp | Pharmaceutical formulations |
DE69617036T2 (en) | 1995-09-07 | 2002-07-11 | Smithkline Beecham Corp | USE OF A PEDIATRIC PHARMACEUTICAL FORMULATION CONTAINING AMOXICILLIN AND CLAVULANATE |
NZ512609A (en) * | 1996-02-29 | 2003-03-28 | Fujisawa Pharmaceutical Co | Synthetic sweeteners, their production and uses thereof |
GB9815532D0 (en) * | 1998-07-17 | 1998-09-16 | Lek Pharmaceutical & Cvhemical | Pharmaceutical suspension formulation |
AU2869100A (en) * | 1999-02-26 | 2000-09-14 | Biovail International Ltd. | Storage stable amoxycillin and clavulanate suspension composition |
CO5170471A1 (en) | 1999-04-13 | 2002-06-27 | Beecham Pharmaceutical Pte Ltd | MODIFIED RELEASE TABLETS INCLUDING AMOXYLIN AND POTASSIUM CLAVULANATE |
CN100417383C (en) * | 2006-03-07 | 2008-09-10 | 中国药科大学 | Effervescent tablet containing cefixime and its preparing method |
EP2015755A4 (en) * | 2006-04-28 | 2010-02-24 | Wockhardt Ltd | Improvements in therapy for treating resistant bacterial infections |
WO2011142730A1 (en) * | 2010-05-14 | 2011-11-17 | Mahmut Bilgic | Pharmaceutical composition comprising cefixime and clavulanic acid derivative compound |
-
2010
- 2010-01-29 TR TR2010/00687A patent/TR201000687A1/en unknown
-
2011
- 2011-01-28 WO PCT/TR2011/000026 patent/WO2011093822A1/en active Application Filing
- 2011-01-28 EP EP11712063A patent/EP2528586A1/en not_active Withdrawn
- 2011-01-28 WO PCT/TR2011/000033 patent/WO2011093829A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
EP2528586A1 (en) | 2012-12-05 |
WO2011093822A1 (en) | 2011-08-04 |
WO2011093829A1 (en) | 2011-08-04 |
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