TR200808115T1 - Process for the Preparation of 4 (S, R) - (3,4-dichlorophenyl) -3,4-dihydro-1 (2H) -naphthalen-1-ylidene] methylamine - Google Patents
Process for the Preparation of 4 (S, R) - (3,4-dichlorophenyl) -3,4-dihydro-1 (2H) -naphthalen-1-ylidene] methylamineInfo
- Publication number
- TR200808115T1 TR200808115T1 TR2008/08115T TR200808115T TR200808115T1 TR 200808115 T1 TR200808115 T1 TR 200808115T1 TR 2008/08115 T TR2008/08115 T TR 2008/08115T TR 200808115 T TR200808115 T TR 200808115T TR 200808115 T1 TR200808115 T1 TR 200808115T1
- Authority
- TR
- Turkey
- Prior art keywords
- salt
- ylidene
- naphthalen
- dichlorophenyl
- methylamine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
- C07C209/52—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of imines or imino-ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/82—Purification; Separation; Stabilisation; Use of additives
- C07C209/86—Separation
- C07C209/88—Separation of optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/02—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/20—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups being part of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Abstract
Mevcut buluş büyük ölçüde saf rasemık sertralın ya da bunun, cıs/trans oranı %85 15'ten büyük olan ve büyük ölçüde deskloro safsızlıklarmdan arınmış olan farmasötık olarak kabul edilebilir tuzlarıyla ilgilidir Proses, ortamda amin tuzu ya da amit tuzu ya da amin tuzu ve amit tuzu karışımı mevcutken, paladyum ve platınyum içeren grup içinden seçilen bir katalıst kullanılarak katalitik hıdrojenasyon (Schıff bazı bileşiği) içerir.The present invention relates to substantially pure racemic sertraline or to pharmaceutically acceptable salts thereof having a cis / trans ratio of greater than 85% 15 and substantially free of desklor impurities. The process comprises an amine salt or amide salt or amine salt and amide salt. salt, while catalytic hydrogenation (Schuff base compound) using a catalyst selected from the group consisting of palladium and platinum.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN674MU2006 | 2006-04-28 | ||
IN911MU2006 | 2006-06-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200808115T1 true TR200808115T1 (en) | 2009-03-23 |
Family
ID=38179585
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2008/08115T TR200808115T1 (en) | 2006-04-28 | 2006-04-26 | Process for the Preparation of 4 (S, R) - (3,4-dichlorophenyl) -3,4-dihydro-1 (2H) -naphthalen-1-ylidene] methylamine |
Country Status (2)
Country | Link |
---|---|
TR (1) | TR200808115T1 (en) |
WO (1) | WO2007124920A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103524354A (en) * | 2013-10-23 | 2014-01-22 | 山东鲁药制药有限公司 | Method for preparing sertraline hydrochloride |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5516415B2 (en) * | 1973-09-06 | 1980-05-01 | ||
US4536518A (en) * | 1979-11-01 | 1985-08-20 | Pfizer Inc. | Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine |
US4960936A (en) * | 1987-12-31 | 1990-10-02 | Ciba-Geigy Corporation | Process for the preparation of halogenated aromatic primary amines |
DE3821013A1 (en) * | 1988-06-22 | 1989-12-28 | Hoechst Ag | METHOD FOR PRODUCING 4-CHLORINE-2,5-DIMETHOXYANILINE |
US5068436A (en) * | 1989-03-10 | 1991-11-26 | E. I. Du Pont De Nemours And Company | Hydrogenation of halonitrobenzenes without dehalogenation |
HU226424B1 (en) * | 1998-05-05 | 2008-12-29 | Egis Gyogyszergyar Nyrt | Process for producing enantiomer mixture for preparation of sertraline |
IL142367A0 (en) * | 1998-10-30 | 2002-03-10 | Ciba Sc Holding Ag | Method of producing ketimines |
WO2000025598A1 (en) * | 1998-11-03 | 2000-05-11 | Dandy A/S | Sucrose fatty acid esters for use as increased release of active ingredients |
CA2448300A1 (en) * | 2001-05-31 | 2002-12-05 | Orion Corporation Fermion | Process for preparing sertraline intermediates |
CA2448499A1 (en) * | 2001-06-15 | 2002-12-27 | Orion Corporation Fermion | A novel process for the preparation of (is-cis) -4-(3, 4-dichlorophenyl) -1, 2, 3, 4 - tetrahydro-n-methyl-1-naphthalenamine |
WO2006027658A2 (en) * | 2004-09-06 | 2006-03-16 | Bakulesh Mafatlal Khamar | Process for the preparation of sertraline hydrochloride form ii |
-
2006
- 2006-04-26 TR TR2008/08115T patent/TR200808115T1/en unknown
-
2007
- 2007-04-26 WO PCT/EP2007/003710 patent/WO2007124920A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2007124920A1 (en) | 2007-11-08 |
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