TR200200975T2 - ATP-Bağlanma kaseti taşıyıcısı (ABC1) tadil edilmiş transjenik fareler - Google Patents

ATP-Bağlanma kaseti taşıyıcısı (ABC1) tadil edilmiş transjenik fareler

Info

Publication number
TR200200975T2
TR200200975T2 TR2002/00975T TR200200975T TR200200975T2 TR 200200975 T2 TR200200975 T2 TR 200200975T2 TR 2002/00975 T TR2002/00975 T TR 2002/00975T TR 200200975 T TR200200975 T TR 200200975T TR 200200975 T2 TR200200975 T2 TR 200200975T2
Authority
TR
Turkey
Prior art keywords
abc1
transgenic mice
atp
binding cassette
cassette carrier
Prior art date
Application number
TR2002/00975T
Other languages
English (en)
Inventor
Leung Leung Wai-Ping
Christiansen-Weber Trudy
R. Voland Joseph
A. Peterson Per
Original Assignee
Ortho-Mcneil Pharmaceutical, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho-Mcneil Pharmaceutical, Inc. filed Critical Ortho-Mcneil Pharmaceutical, Inc.
Publication of TR200200975T2 publication Critical patent/TR200200975T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Environmental Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Bir abc1 geninde farklilasmalara sahip bir transgenik fare, bir degistirilmis abc1 geninin bir konukçu hayvana katilmasi ile hazirlanmaktadir. Sonuçtaki transjenik fareler islevsel ABC1 protein moleküllerini üretmemektedir. Bu hayvanlardan hücreler ve hücre kusaklari da degistirilmis abc1 genini ihtiva etmektedir.
TR2002/00975T 1999-10-13 2000-10-05 ATP-Bağlanma kaseti taşıyıcısı (ABC1) tadil edilmiş transjenik fareler TR200200975T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/417,619 US6225525B1 (en) 1999-10-13 1999-10-13 ATP-binding cassette transporter (ABC1) modified transgenic mice

Publications (1)

Publication Number Publication Date
TR200200975T2 true TR200200975T2 (tr) 2002-09-23

Family

ID=23654720

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2002/00975T TR200200975T2 (tr) 1999-10-13 2000-10-05 ATP-Bağlanma kaseti taşıyıcısı (ABC1) tadil edilmiş transjenik fareler

Country Status (7)

Country Link
US (1) US6225525B1 (tr)
EP (1) EP1237405A1 (tr)
JP (1) JP2003533171A (tr)
AU (1) AU7871300A (tr)
CA (1) CA2385154A1 (tr)
TR (1) TR200200975T2 (tr)
WO (1) WO2001026453A1 (tr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6835563B1 (en) 1999-06-18 2004-12-28 Cv Therapeutics Compositions and methods for increasing cholesterol efflux and raising HDL ATP binding cassette transporter protein ABC1
US6821774B1 (en) 1999-06-18 2004-11-23 Cv Therapeutics, Inc. Compositions and methods for increasing cholesterol efflux and raising HDL using ATP binding cassette transporter ABC1
US20020107232A1 (en) * 2001-01-12 2002-08-08 Flickinger Brent D. Methods for producing sterol ester-rich compositions
WO2003087406A1 (en) * 2002-04-18 2003-10-23 Evotec Neurosciences Gmbh Diagnostic and therapeutic use of an atp-binding cassette gene and protein for neurodegenerative diseases
ES2916325T3 (es) * 2015-11-05 2022-06-30 Massachusetts Gen Hospital Administración intratecal de secuencias de ácidos nucleicos codificantes de ABCD1 para el tratamiento de la adrenomieloneuropatía
CN109456996B (zh) * 2018-11-19 2021-09-24 河北伊维沃生物科技有限公司 构建abca1基因敲除仓鼠模型的试剂盒和方法

Also Published As

Publication number Publication date
WO2001026453A1 (en) 2001-04-19
EP1237405A1 (en) 2002-09-11
JP2003533171A (ja) 2003-11-11
AU7871300A (en) 2001-04-23
CA2385154A1 (en) 2001-04-19
US6225525B1 (en) 2001-05-01

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