TR200102730T2 - New method for the production of doxazosin mesylate in crystal modification. - Google Patents

New method for the production of doxazosin mesylate in crystal modification.

Info

Publication number
TR200102730T2
TR200102730T2 TR2001/02730T TR200102730T TR200102730T2 TR 200102730 T2 TR200102730 T2 TR 200102730T2 TR 2001/02730 T TR2001/02730 T TR 2001/02730T TR 200102730 T TR200102730 T TR 200102730T TR 200102730 T2 TR200102730 T2 TR 200102730T2
Authority
TR
Turkey
Prior art keywords
production
doxazosin
new method
crystal modification
doxazosin mesylate
Prior art date
Application number
TR2001/02730T
Other languages
Turkish (tr)
Inventor
Klein Peter
Thyes Mar�O
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of TR200102730T2 publication Critical patent/TR200102730T2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

A modifikasyonunda doksazosin-mesilatin üretimine yönelik bir yöntem olup, doksazosinin, metansulfonik asit ile birlikte aprotik, polar organik bir çözücü ve metanolden meydana gelen bir karisim içerisinde çözülmesi ve bu islem sirasinda çökelen çözeltinin gerektiginde bulanikliginin giderilmesi ve bu islem sirasinda çökelen berrak çözeltinin gerektiginde A formunun doksazosin-mesilat kristalleri ile asilanmasi, isitilmasi, olusan ürün sogutulduktan sonra izole edilmesi, organik bir çözücü ile yikanmasi ve kurutulmasi islemlerinden ibarettir.A method for the production of doxazosin-meslatin in modification A, where doxazosin is dissolved together with methanesulfonic acid in a mixture consisting of an aprotic, polar organic solvent and methanol, and the solution of the solution precipitated during this process is required and the clear solution precipitated during this process is required. It consists of hanging, heating with doxazosin-mesylate crystals, isolating the product after cooling, washing and drying with an organic solvent.

TR2001/02730T 1999-03-18 2000-03-06 New method for the production of doxazosin mesylate in crystal modification. TR200102730T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19912063A DE19912063A1 (en) 1999-03-18 1999-03-18 New process for the preparation of doxazosin mesylate in a crystal modification called Form A.

Publications (1)

Publication Number Publication Date
TR200102730T2 true TR200102730T2 (en) 2002-06-21

Family

ID=7901411

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/02730T TR200102730T2 (en) 1999-03-18 2000-03-06 New method for the production of doxazosin mesylate in crystal modification.

Country Status (13)

Country Link
EP (1) EP1165548A1 (en)
JP (1) JP2002540109A (en)
KR (1) KR20010113753A (en)
CN (1) CN1352643A (en)
AU (1) AU3960800A (en)
CA (1) CA2367903A1 (en)
CZ (1) CZ20013347A3 (en)
DE (1) DE19912063A1 (en)
HU (1) HUP0200663A2 (en)
IL (1) IL144944A0 (en)
PL (1) PL350088A1 (en)
TR (1) TR200102730T2 (en)
WO (1) WO2000056731A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19912573A1 (en) * 1999-03-19 2000-09-21 Knoll Ag Medicament containing doxazosin mesylate of crystal modification D
AU2008339652B2 (en) * 2007-12-24 2013-07-04 Cipla Limited Crystalline polymorph of doxazosin mesylate (form IV) and process for preparation thereof
CN109988158A (en) * 2018-01-03 2019-07-09 合肥立方制药股份有限公司 X crystal form, doxazosin mesylate containing X crystal form and its preparation method and application
CN111303130B (en) * 2018-12-11 2021-09-14 合肥立方制药股份有限公司 Doxazosin mesylate crystal form, and preparation method and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1287588B1 (en) * 1996-12-13 1998-08-06 Alfa Chem Ital CRYSTALLINE FORM OF MESILATE DOXAZOSIN AND PROCESS FOR ITS PRODUCTION
ATE353892T1 (en) * 1996-12-20 2007-03-15 Heumann Pharma Gmbh & Co NEW POLYMORPHOUS FORM OF DOXAZOSINE MESYLATE (FORM III)
DE19800214A1 (en) * 1998-01-06 1999-07-15 Knoll Ag Process for the preparation of doxazosin mcsylate in a crystal modification referred to as Form A and an intermediate therefor

Also Published As

Publication number Publication date
DE19912063A1 (en) 2000-09-21
HUP0200663A2 (en) 2002-08-28
WO2000056731A1 (en) 2000-09-28
KR20010113753A (en) 2001-12-28
AU3960800A (en) 2000-10-09
JP2002540109A (en) 2002-11-26
EP1165548A1 (en) 2002-01-02
PL350088A1 (en) 2002-11-04
IL144944A0 (en) 2002-06-30
CZ20013347A3 (en) 2002-01-16
CA2367903A1 (en) 2000-09-28
CN1352643A (en) 2002-06-05

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