TR200100873T2 - Fermentation of clavulanic acid at a controlled ammonia level - Google Patents

Fermentation of clavulanic acid at a controlled ammonia level

Info

Publication number
TR200100873T2
TR200100873T2 TR2001/00873T TR200100873T TR200100873T2 TR 200100873 T2 TR200100873 T2 TR 200100873T2 TR 2001/00873 T TR2001/00873 T TR 2001/00873T TR 200100873 T TR200100873 T TR 200100873T TR 200100873 T2 TR200100873 T2 TR 200100873T2
Authority
TR
Turkey
Prior art keywords
clavulanic acid
fermentation
ammonia level
controlled ammonia
controlled
Prior art date
Application number
TR2001/00873T
Other languages
Turkish (tr)
Inventor
Visser-Luirink Gesina
Theodorus Antonius Maria De Laat Wilhelmus
Martijin Klop Jeroen
Original Assignee
Dsm N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm N.V. filed Critical Dsm N.V.
Publication of TR200100873T2 publication Critical patent/TR200100873T2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Abstract

Bir klavülanik asit üreten mikroorganizmanin kontrol edilen en az 50 mg/l'lik amonyak düzeyinde mayalanmasi ile klavülanik asitin üretilmesi için bir yöntem tedarik edilmistir. Bu tepkime kosullarinin uygulanmasi ile, sasirtici olarak yüksek üretim düzeylerinde klavülanik asit elde edilmistir.A method for producing clavulanic acid is provided by fermentation of a microorganism producing a clavulanic acid to a controlled level of ammonia of at least 50 mg / l. By applying these reaction conditions, surprisingly high production levels of clavulanic acid were obtained.

TR2001/00873T 1998-09-29 1999-09-23 Fermentation of clavulanic acid at a controlled ammonia level TR200100873T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98203314 1998-09-29

Publications (1)

Publication Number Publication Date
TR200100873T2 true TR200100873T2 (en) 2001-07-23

Family

ID=8234177

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/00873T TR200100873T2 (en) 1998-09-29 1999-09-23 Fermentation of clavulanic acid at a controlled ammonia level

Country Status (6)

Country Link
EP (1) EP1117820A1 (en)
CN (1) CN1198940C (en)
AU (1) AU6089699A (en)
CA (1) CA2342181A1 (en)
TR (1) TR200100873T2 (en)
WO (1) WO2000018947A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008132531A1 (en) * 2007-04-27 2008-11-06 Council Of Scientific And Industrial Research Process for the preparation of clavulanic acid employing streptomyces clavuligerus mtcc 1142 in a solid state fermentation
BR112016007286B1 (en) * 2013-10-02 2021-07-20 Ajinomoto Co., Inc METHODS FOR THE CONTROL OF AMMONIA AND FOR THE PRODUCTION OF A TARGET SUBSTANCE, AND, APPARATUS FOR THE CONTROL OF AMMONIA

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3063683D1 (en) * 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
GB9424950D0 (en) * 1994-12-10 1995-02-08 Smithkline Beecham Plc Novel process
SI9600120A (en) * 1996-04-12 1997-12-31 Lek Tovarna Farmacevtskih New and improved fermentative procedure for the production of clavulanic acid and its salts

Also Published As

Publication number Publication date
WO2000018947A1 (en) 2000-04-06
CN1320166A (en) 2001-10-31
CN1198940C (en) 2005-04-27
AU6089699A (en) 2000-04-17
EP1117820A1 (en) 2001-07-25
CA2342181A1 (en) 2000-04-06

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