TR199903022T2 - 5-Naphthalin-1-yl-1, 3-dioxane derivatives, preparations and therapeutic applications. - Google Patents

5-Naphthalin-1-yl-1, 3-dioxane derivatives, preparations and therapeutic applications.

Info

Publication number
TR199903022T2
TR199903022T2 TR1999/03022T TR9903022T TR199903022T2 TR 199903022 T2 TR199903022 T2 TR 199903022T2 TR 1999/03022 T TR1999/03022 T TR 1999/03022T TR 9903022 T TR9903022 T TR 9903022T TR 199903022 T2 TR199903022 T2 TR 199903022T2
Authority
TR
Turkey
Prior art keywords
group
optionally substituted
nitrogen
naphthalin
preparations
Prior art date
Application number
TR1999/03022T
Other languages
Turkish (tr)
Inventor
Dargazanli Gihad
Lardenois Patrick
Frost Jonathan
George Pascal
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9706947A external-priority patent/FR2764291B1/en
Priority claimed from FR9706944A external-priority patent/FR2764287B1/en
Priority claimed from FR9706945A external-priority patent/FR2764288B1/en
Priority claimed from FR9706946A external-priority patent/FR2764289B1/en
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Publication of TR199903022T2 publication Critical patent/TR199903022T2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Genel formül (I)'deki bilesikler olup, FORMÜL 1 söz konusu formüldeki R1, bir alkil grubunu simgelemekte; V, bir hidrojen atomunu, düz veya dalli bir alkil grubunu, bir saykloalkil grubunu, bir saykloalkilmetil grubu, fenil halkasi üzerinde istege bagli olarak substitüsyonu gerçeklestirilen bir fenilalkil grubunu, bir karboksimetil grubunu, bir alkoksikarbonilmetil grubunu veya istege bagli olarak nitrojen üzerinde substitüsyonu gerçeklestirilen bir karbamoylmetil grubunu simgelemekte; W, bir karboksimetil grubunu, bir alkoksikarbonilmetil grubunu, nitrojen üzerinde istege bagli olarak substitüsyonu gerçeklestirilen bir karbamoylmetil grubunu, istege bagli olarak bir oksijen veya sülfür atomunu ihtiva eden 4 ila 7 üyeli bir sayklik grubu, bir piridilmetil grubunu, bir 1-metilpirolilmetil grubunu, bir furilmetil grubunu, bir tiyenilmetil grubunu veya bir 1,3-tiyazolilmetil grubunu simgelemekte veya alternatif olarak, V ve W; nitrojen atomu ile birlikte, bir (DEVAMI VAR)Compounds of the general formula (I) wherein FORMUL 1 represents R1 in said formula, an alkyl group; V is a hydrogen atom, a straight or branched alkyl group, a cycloalkyl group, a cycloalkylmethyl group, a phenylalkyl group which is optionally substituted on the phenyl ring, an alkoxycarbonylmethyl group or optionally substituted on nitrogen carbylmethyl. symbolizes the group; W is a carboxymethyl group, an alkoxycarbonylmethyl group, a carbamoylmethyl group optionally substituted on nitrogen, a 4 to 7 membered cyclic group, a pyridylmethyl group, a 1-methylpyrrolylmethyl group, symbolizes the furylmethyl group, a thienylmethyl group or a 1,3-thiazolylmethyl group, or alternatively, V and W; Along with the nitrogen atom, a (CONTINUED)

TR1999/03022T 1997-06-05 1998-06-03 5-Naphthalin-1-yl-1, 3-dioxane derivatives, preparations and therapeutic applications. TR199903022T2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9706947A FR2764291B1 (en) 1997-06-05 1997-06-05 5-NAPHTALEN-1-YL-1,3-DIOXANE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR9706944A FR2764287B1 (en) 1997-06-05 1997-06-05 5-NAPHTALEN-1-YL-1,3-DIOXANES DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR9706945A FR2764288B1 (en) 1997-06-05 1997-06-05 5-NAPHTALEN-1-YL-1,3-DIOXANE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR9706946A FR2764289B1 (en) 1997-06-05 1997-06-05 5-NAPHTALEN-1-YL-1,3-DIOXANE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (1)

Publication Number Publication Date
TR199903022T2 true TR199903022T2 (en) 2000-04-21

Family

ID=27447000

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/03022T TR199903022T2 (en) 1997-06-05 1998-06-03 5-Naphthalin-1-yl-1, 3-dioxane derivatives, preparations and therapeutic applications.

Country Status (18)

Country Link
EP (1) EP0986552A1 (en)
JP (1) JP2002502412A (en)
KR (1) KR20010013435A (en)
CN (1) CN1265658A (en)
AR (1) AR012908A1 (en)
AU (1) AU8025198A (en)
BG (1) BG103937A (en)
BR (1) BR9810742A (en)
CA (1) CA2290695A1 (en)
CO (1) CO4940480A1 (en)
EE (1) EE9900560A (en)
HU (1) HUP0002166A3 (en)
IL (1) IL133242A0 (en)
NO (1) NO995966L (en)
PL (1) PL337234A1 (en)
SK (1) SK166199A3 (en)
TR (1) TR199903022T2 (en)
WO (1) WO1998055474A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL365701A1 (en) * 2000-07-21 2005-01-10 Ortho-Mcneil Pharmaceutical, Inc. Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain
FR2843964B1 (en) * 2002-08-29 2004-10-01 Sanofi Synthelabo DIOXANE-2-ALKYLCARBAMATES DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE111460T1 (en) * 1990-06-15 1994-09-15 Synthelabo 2-(AMINOALKYL)-5-(ARYLALKYL)1,3-DIOXANE DERIVATIVES, THEIR PRODUCTION AND APPLICATIONS IN THERAPEUTICS.
FR2714055B1 (en) * 1993-12-22 1996-01-19 Synthelabo Derivatives of 5- (arylalkyl) -1,3-dioxane substituted in position 2, their preparation and their use in therapy.
FR2742152B1 (en) * 1995-12-06 1998-01-16 Synthelabo 5-NAPHTALEN-1-YL-1,3-DIOXANES DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Also Published As

Publication number Publication date
WO1998055474A1 (en) 1998-12-10
JP2002502412A (en) 2002-01-22
CO4940480A1 (en) 2000-07-24
IL133242A0 (en) 2001-03-19
BG103937A (en) 2000-07-31
PL337234A1 (en) 2000-08-14
NO995966D0 (en) 1999-12-03
HUP0002166A3 (en) 2002-12-28
EE9900560A (en) 2000-06-15
EP0986552A1 (en) 2000-03-22
BR9810742A (en) 2000-09-12
HUP0002166A2 (en) 2001-06-28
CN1265658A (en) 2000-09-06
AR012908A1 (en) 2000-11-22
NO995966L (en) 2000-02-04
CA2290695A1 (en) 1998-12-10
KR20010013435A (en) 2001-02-26
SK166199A3 (en) 2000-06-12
AU8025198A (en) 1998-12-21

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TR199903022T2 (en) 5-Naphthalin-1-yl-1, 3-dioxane derivatives, preparations and therapeutic applications.