TR199801749T2 - 4-Amino-pyrimidine-derivatives and drugs containing them - Google Patents
4-Amino-pyrimidine-derivatives and drugs containing themInfo
- Publication number
- TR199801749T2 TR199801749T2 TR1998/01749T TR9801749T TR199801749T2 TR 199801749 T2 TR199801749 T2 TR 199801749T2 TR 1998/01749 T TR1998/01749 T TR 1998/01749T TR 9801749 T TR9801749 T TR 9801749T TR 199801749 T2 TR199801749 T2 TR 199801749T2
- Authority
- TR
- Turkey
- Prior art keywords
- pyrimidine
- derivatives
- amino
- drugs containing
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
Yukaridaki bulus, içinde Ra,Rb, A ve B'nin istem 1'de tanimlandigi gibi oldugu genel formül (I)'in 4-amino-pirimidin-türevleri, bunlarin tautomerleri, stereoizomerleri ve tuzlari, özellikle farmakolojik olarak degerli özelliklerde titrosinkinazlar ile bildirilen sinyal transdüksiyonun önleme etkisi özelliklerine sahip olan anorganik ya da organik asit ya da bazlar ile birlikte bunlarin fizyolojik olarak uygun tuzlari, bunlarin hastaliklarin özelliklede tümör hastaliklarinin tedavisi için kullanimi ve bunlanir elde edilmesi ile ilgilidir. FORMÜL.The above invention is reported by the 4-amino-pyrimidine-derivatives of the general formula (I) in which Ra, Rb, A, and B are as defined in claim 1, their tautomers, stereoisomers and salts, in particular pharmacologically valuable titrosynkinases. Inorganic or organic acids or bases, together with their signal transduction inhibitory properties, are concerned with their physiologically acceptable salts, their use for the treatment of diseases, and particularly their treatment of tumor diseases. FORMULA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1996108631 DE19608631A1 (en) | 1996-03-06 | 1996-03-06 | New (heterocyclyl- pyrimidino or -pyrido)fused pyrimidine derivatives |
DE19629652A DE19629652A1 (en) | 1996-03-06 | 1996-07-23 | 4-Amino-pyrimidine derivatives, medicaments containing these compounds, their use and processes for their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
TR199801749T2 true TR199801749T2 (en) | 1998-12-21 |
Family
ID=26023531
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR1998/01749T TR199801749T2 (en) | 1996-03-06 | 1997-03-03 | 4-Amino-pyrimidine-derivatives and drugs containing them |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0885226A1 (en) |
JP (1) | JP2000506847A (en) |
KR (1) | KR19990087550A (en) |
CN (1) | CN1212695A (en) |
AU (1) | AU710274B2 (en) |
BG (1) | BG102708A (en) |
BR (1) | BR9708312A (en) |
CA (1) | CA2243994A1 (en) |
CZ (1) | CZ281798A3 (en) |
DE (1) | DE19629652A1 (en) |
EE (1) | EE9800277A (en) |
HU (1) | HUP9901820A3 (en) |
IL (1) | IL125404A0 (en) |
NO (1) | NO984084L (en) |
NZ (1) | NZ331546A (en) |
PL (1) | PL328771A1 (en) |
SK (1) | SK120598A3 (en) |
TR (1) | TR199801749T2 (en) |
WO (1) | WO1997032881A1 (en) |
Families Citing this family (76)
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EP1396489A1 (en) * | 1999-01-27 | 2004-03-10 | Pfizer Products Inc. | Heteroaromatic bicyclic derivatives useful as anticancer agents |
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UA72946C2 (en) | 1999-11-05 | 2005-05-16 | Астразенека Аб | Quinasoline derivatives as inhibitors of vascular endothelial growth factor (vegf) |
BRPI0411608A (en) | 2003-06-24 | 2006-08-08 | Neurosearch As | 8-aza-bicyclo [3.2.1] octane derivative, pharmaceutical composition, use of the compound, and method of treating, preventing or alleviating a disease, disorder or condition of a living animal organism |
MX2007010068A (en) * | 2005-02-16 | 2007-10-10 | Schering Corp | Piperazine-piperidines with cxcr3 antagonist activity. |
EP2349235A1 (en) | 2008-11-07 | 2011-08-03 | Triact Therapeutics, Inc. | Use of catecholic butane derivatives in cancer therapy |
CA2745041C (en) * | 2008-12-01 | 2017-08-22 | Kai Schiemann | 2, 5-diamino-substituted pyrido [4, 3-d] pyrimidines as autotaxin inhibitors against cancer |
US20120189641A1 (en) | 2009-02-25 | 2012-07-26 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
JP2012519170A (en) | 2009-02-26 | 2012-08-23 | オーエスアイ・ファーマシューティカルズ,エルエルシー | INSITU method for monitoring EMT status of tumor cells in vivo |
WO2010099138A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
WO2010099364A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
WO2010099363A1 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
WO2010107968A1 (en) | 2009-03-18 | 2010-09-23 | Osi Pharmaceuticals, Inc. | Combination cancer therapy comprising administration of an egfr inhibitor and an igf-1r inhibitor |
JP2013510564A (en) | 2009-11-13 | 2013-03-28 | パンガエア ビオテック、ソシエダッド、リミターダ | Molecular biomarkers for predicting response to tyrosine kinase inhibitors in lung cancer |
EP2468883A1 (en) | 2010-12-22 | 2012-06-27 | Pangaea Biotech S.L. | Molecular biomarkers for predicting response to tyrosine kinase inhibitors in lung cancer |
US9134297B2 (en) | 2011-01-11 | 2015-09-15 | Icahn School Of Medicine At Mount Sinai | Method and compositions for treating cancer and related methods |
EP2492688A1 (en) | 2011-02-23 | 2012-08-29 | Pangaea Biotech, S.A. | Molecular biomarkers for predicting response to antitumor treatment in lung cancer |
WO2012129145A1 (en) | 2011-03-18 | 2012-09-27 | OSI Pharmaceuticals, LLC | Nscle combination therapy |
WO2012149014A1 (en) | 2011-04-25 | 2012-11-01 | OSI Pharmaceuticals, LLC | Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment |
CA2845179A1 (en) | 2011-08-31 | 2013-03-07 | Genentech, Inc. | Diagnostic markers |
JP2014531213A (en) | 2011-09-30 | 2014-11-27 | ジェネンテック, インコーポレイテッド | Diagnostic methylation markers for epithelial or mesenchymal phenotype and response to EGFR kinase inhibitors in tumors or tumor cells |
WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
WO2013190089A1 (en) | 2012-06-21 | 2013-12-27 | Pangaea Biotech, S.L. | Molecular biomarkers for predicting outcome in lung cancer |
EP2961412A4 (en) | 2013-02-26 | 2016-11-09 | Triact Therapeutics Inc | Cancer therapy |
WO2014147246A1 (en) | 2013-03-21 | 2014-09-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method and pharmaceutical composition for use in the treatment of chronic liver diseases associated with a low hepcidin expression |
WO2015035410A1 (en) | 2013-09-09 | 2015-03-12 | Triact Therapeutic, Inc. | Cancer therapy |
WO2015156674A2 (en) | 2014-04-10 | 2015-10-15 | Stichting Het Nederlands Kanker Instituut | Method for treating cancer |
AU2015371312B2 (en) | 2014-12-24 | 2022-01-27 | Genentech, Inc. | Therapeutic, diagnostic and prognostic methods for cancer of the bladder |
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WO2020132653A1 (en) | 2018-12-20 | 2020-06-25 | Amgen Inc. | Heteroaryl amides useful as kif18a inhibitors |
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SG11202109036WA (en) | 2019-03-01 | 2021-09-29 | Revolution Medicines Inc | Bicyclic heteroaryl compounds and uses thereof |
AU2020232616A1 (en) | 2019-03-01 | 2021-09-09 | Revolution Medicines, Inc. | Bicyclic heterocyclyl compounds and uses thereof |
EP3738593A1 (en) | 2019-05-14 | 2020-11-18 | Amgen, Inc | Dosing of kras inhibitor for treatment of cancers |
CN114144414A (en) | 2019-05-21 | 2022-03-04 | 美国安进公司 | Solid state form |
MX2022001295A (en) | 2019-08-02 | 2022-02-22 | Amgen Inc | Kif18a inhibitors. |
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EP4007638A1 (en) | 2019-08-02 | 2022-06-08 | Amgen Inc. | Pyridine derivatives as kif18a inhibitors |
AU2020324963A1 (en) | 2019-08-02 | 2022-02-24 | Amgen Inc. | KIF18A inhibitors |
WO2021081212A1 (en) | 2019-10-24 | 2021-04-29 | Amgen Inc. | Pyridopyrimidine derivatives useful as kras g12c and kras g12d inhibitors in the treatment of cancer |
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TW202132314A (en) | 2019-11-04 | 2021-09-01 | 美商銳新醫藥公司 | Ras inhibitors |
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TW202340214A (en) | 2021-12-17 | 2023-10-16 | 美商健臻公司 | Pyrazolopyrazine compounds as shp2 inhibitors |
EP4227307A1 (en) | 2022-02-11 | 2023-08-16 | Genzyme Corporation | Pyrazolopyrazine compounds as shp2 inhibitors |
WO2023172940A1 (en) | 2022-03-08 | 2023-09-14 | Revolution Medicines, Inc. | Methods for treating immune refractory lung cancer |
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Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
DE4431867A1 (en) * | 1994-09-07 | 1996-03-14 | Thomae Gmbh Dr K | New 4-amino-pyrimido-pyrimidine derivs. |
-
1996
- 1996-07-23 DE DE19629652A patent/DE19629652A1/en not_active Ceased
-
1997
- 1997-03-03 BR BR9708312A patent/BR9708312A/en not_active IP Right Cessation
- 1997-03-03 SK SK1205-98A patent/SK120598A3/en unknown
- 1997-03-03 HU HU9901820A patent/HUP9901820A3/en unknown
- 1997-03-03 CA CA002243994A patent/CA2243994A1/en not_active Abandoned
- 1997-03-03 NZ NZ331546A patent/NZ331546A/en unknown
- 1997-03-03 CZ CZ982817A patent/CZ281798A3/en unknown
- 1997-03-03 CN CN97192787A patent/CN1212695A/en active Pending
- 1997-03-03 TR TR1998/01749T patent/TR199801749T2/en unknown
- 1997-03-03 EE EE9800277A patent/EE9800277A/en unknown
- 1997-03-03 EP EP97907066A patent/EP0885226A1/en not_active Ceased
- 1997-03-03 JP JP9531444A patent/JP2000506847A/en active Pending
- 1997-03-03 PL PL97328771A patent/PL328771A1/en unknown
- 1997-03-03 AU AU19251/97A patent/AU710274B2/en not_active Ceased
- 1997-03-03 KR KR1019980706987A patent/KR19990087550A/en not_active Application Discontinuation
- 1997-03-03 WO PCT/EP1997/001057 patent/WO1997032881A1/en not_active Application Discontinuation
- 1997-03-03 IL IL12540497A patent/IL125404A0/en unknown
-
1998
- 1998-08-20 BG BG102708A patent/BG102708A/en unknown
- 1998-09-04 NO NO984084A patent/NO984084L/en unknown
Also Published As
Publication number | Publication date |
---|---|
HUP9901820A2 (en) | 1999-09-28 |
CN1212695A (en) | 1999-03-31 |
NO984084D0 (en) | 1998-09-04 |
DE19629652A1 (en) | 1998-01-29 |
AU1925197A (en) | 1997-09-22 |
BG102708A (en) | 1999-09-30 |
AU710274B2 (en) | 1999-09-16 |
CA2243994A1 (en) | 1997-09-12 |
SK120598A3 (en) | 1999-06-11 |
EP0885226A1 (en) | 1998-12-23 |
EE9800277A (en) | 1999-02-15 |
JP2000506847A (en) | 2000-06-06 |
CZ281798A3 (en) | 1999-02-17 |
BR9708312A (en) | 1999-08-03 |
NO984084L (en) | 1998-09-04 |
PL328771A1 (en) | 1999-02-15 |
KR19990087550A (en) | 1999-12-27 |
NZ331546A (en) | 2000-03-27 |
HUP9901820A3 (en) | 2001-10-29 |
IL125404A0 (en) | 1999-03-12 |
WO1997032881A1 (en) | 1997-09-12 |
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