TJ294B - Method for selective methionine starvation of malignant cells in mammals - Google Patents

Method for selective methionine starvation of malignant cells in mammals

Info

Publication number
TJ294B
TJ294B TJ96000320A TJ96000320A TJ294B TJ 294 B TJ294 B TJ 294B TJ 96000320 A TJ96000320 A TJ 96000320A TJ 96000320 A TJ96000320 A TJ 96000320A TJ 294 B TJ294 B TJ 294B
Authority
TJ
Tajikistan
Prior art keywords
malignant cells
mammal
mtase
mammals
methionine
Prior art date
Application number
TJ96000320A
Inventor
Tsutomu Nobori
Dennis Carson
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of TJ294B publication Critical patent/TJ294B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

An improved method for chemotherapy of mammalian malignant cells which have an absolute requirement for methionine but lack methylthioadenosine phosphorylase (MTAse). The method comprises detection of MTAse negative cells in a mammal, administration of methionine gamma -lyase in sufficient amounts to reduce the volume of MTAse negative cells in the mammal, and co-administration of methylthioadenosine in amounts sufficient to ensure the continued availability of methionine to the mammal's non-malignant cells. Means for detection of MTAse negative cells are provided. Means for production and use of recombinant chemotherapeutic agents are also provided.
TJ96000320A 1993-12-29 1994-12-22 Method for selective methionine starvation of malignant cells in mammals TJ294B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/176,413 US5571510A (en) 1993-12-29 1993-12-29 Method for selective methionine starvation of malignant cells in mammals
PCT/US1994/014919 WO1995017908A1 (en) 1993-12-29 1994-12-22 Method for selective methionine starvation of malignant cells in mammals

Publications (1)

Publication Number Publication Date
TJ294B true TJ294B (en) 2001-03-30

Family

ID=22644262

Family Applications (1)

Application Number Title Priority Date Filing Date
TJ96000320A TJ294B (en) 1993-12-29 1994-12-22 Method for selective methionine starvation of malignant cells in mammals

Country Status (17)

Country Link
US (1) US5571510A (en)
EP (1) EP0805690B1 (en)
JP (1) JPH09507754A (en)
CN (1) CN1143325A (en)
AT (1) ATE221785T1 (en)
AU (1) AU694161B2 (en)
CA (1) CA2180262A1 (en)
CZ (1) CZ291281B6 (en)
DE (1) DE69431167T2 (en)
HU (1) HU221341B1 (en)
NO (1) NO962714L (en)
NZ (1) NZ278271A (en)
PL (1) PL182298B1 (en)
RO (1) RO117542B1 (en)
RU (1) RU2153885C2 (en)
TJ (1) TJ294B (en)
WO (1) WO1995017908A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6461851B1 (en) 1992-11-19 2002-10-08 Anticancer, Inc. High expression modules containing two or more tandem copies of a methioninase encoding sequence
US5891704A (en) * 1992-11-19 1999-04-06 Anticancer, Inc. Method to produce high levels of methioninase
US6911309B2 (en) * 1993-12-29 2005-06-28 The Regents Of The University Of Californnia Nucleic acids encoding MTAse
US6870037B1 (en) * 1995-07-03 2005-03-22 Arch Development Corporation Methylthioadenosine phosphorylase compositions and methods of use in the diagnosis and treatment of proliferative disorders
US5861154A (en) * 1995-10-30 1999-01-19 Shionogi & Co., Ltd. Recombinant L-methionine γ-lyase
AU2001280155A1 (en) * 2000-09-05 2002-03-22 Shionogi And Co., Ltd. L-methionine gamma-lyase with modified function
WO2003020305A1 (en) * 2001-08-30 2003-03-13 Baylor College Of Medecine Methionine restriction for cancer therapy
US20040127435A1 (en) * 2002-08-02 2004-07-01 Regents Of The University Of California Uses for inhibitors of inosine monophosphate dehydrogenase
EP1594900A2 (en) 2003-02-14 2005-11-16 Salmedix, Inc. Compositions and methods for the detection and treatment of methylthioadenosine phosphorylase deficient cancers
US20110002978A1 (en) * 2003-06-17 2011-01-06 Harrison Roger G Enzyme prodrug cancer therapy selectively targeted to tumor cells or tumor vasculature and methods of production and use thereof
US8796241B2 (en) 2007-08-29 2014-08-05 Adam Lubin Therapy of tumors and infectious agents deficient in methylthioadenosine phosphorylase
WO2009140007A2 (en) * 2008-04-14 2009-11-19 Ats Medical, Inc. Tool for implantation of replacement heart valve
US9987241B2 (en) 2014-09-25 2018-06-05 The Board Of Regents Of The University Of Oklahoma Enzyme conjugate and prodrug cancer therapy
WO2020032951A1 (en) 2018-08-09 2020-02-13 The Board Of Regents Of The University Of Oklahoma Antimalarial enzyme conjugates, kits containing same, and methods of producing and using same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US5122614A (en) * 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides

Also Published As

Publication number Publication date
US5571510A (en) 1996-11-05
CN1143325A (en) 1997-02-19
EP0805690A1 (en) 1997-11-12
NZ278271A (en) 2001-07-27
HUT75070A (en) 1997-04-28
DE69431167T2 (en) 2003-04-17
EP0805690A4 (en) 1999-05-12
RO117542B1 (en) 2002-04-30
NO962714L (en) 1996-08-26
CA2180262A1 (en) 1995-07-06
HU9601695D0 (en) 1996-08-28
WO1995017908A1 (en) 1995-07-06
AU1445995A (en) 1995-07-17
CZ291281B6 (en) 2003-01-15
HU221341B1 (en) 2002-09-28
CZ186996A3 (en) 1996-12-11
JPH09507754A (en) 1997-08-12
PL182298B1 (en) 2001-12-31
EP0805690B1 (en) 2002-08-07
AU694161B2 (en) 1998-07-16
NO962714D0 (en) 1996-06-27
ATE221785T1 (en) 2002-08-15
RU2153885C2 (en) 2000-08-10
DE69431167D1 (en) 2002-09-12

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