TH9980C3 - The preparation process of losone methew ether polymer lignanparticle With polyelectrolyte complexion techniques - Google Patents

Abstract

DC60 (28/03/57) Process for the preparation of losone-methyl ether nanoparticles using polyelectrolyte complexion techniques. The procedure is as follows: conduct (i) losone methew ether dissolve in losone methyther (ii) solvent polymer. Remove it in water and add surfactant to mix well. (Iii) Dissolve chitosan in acetic acid. Then drop solution (i) into solution (ii) under evenly stirring. Then, the above mixture is slowly dripped into the solution (iii) or drip (iii) into the (i) and (iii) mixtures under evenly stirring. Next, add stabilizer under evenly blending. Lozone methyl ether nanoparticle that was dispersed in water was found that losone methyl ether nanoparticle prepared with polyelectrolyte complex It has a particle size of 250-700 nm, with a positive charge of 20-30 millivolt, can control the release of losone-methyther for at least 3 hours and has the ability to adhere to the mucous membranes for more than 6 hours More than 40% losone methew ether was also found, while non-containment of losone methew ether in the nanoparticle. Found seized Less than 30% of the island after 1 hour. The process of preparing losone methew ether nanoparticle using polyelectrolyte complexion technique. The steps are as follows: i) dissolve losone methyther in the solvent azone methyther (ii) dissolve the polymer. Anion in water and add surfactant to mix well. (Iii) Dissolve chitosan in acetic acid. Then drop the solution (i) into solution (ii) under evenly agitation. Then, the above mixture is slowly dripped into the solution (iii) or drip (iii) into the (i) and (iii) mixtures under evenly stirring. Next, add stabilizer under evenly blending. Lozone methyl ether nanoparticle was found to be dispersed in water. It was found that losone methyl ether nanoparticle was prepared with polyelectrolyte technique. The plexisation has a particle size of 250-700 nm, has a positive charge of 20-30 millivolt, can control the release of losone-methyl ether for at least 3 hours and has mucosal binding properties. For more than 6 hours, more than 40% of losone methyl ether was found, while losone methyl ether was not retained in the nanoparticle. Found seized Less than 30 percent of the islands after an hour.

Claims (1)

1. Process for the preparation of losone-methyl ether nanoparticle using polyelectrolyte complexion technique. It has the following components: C-Loson Methew Ether 0.010-0.2% W / v - Chitosan 0.01-0.2% W / v - Anionic polymer 0.01-0.2% W / v - Dsol Azone methyl ether 0.1-2% W / v - surfactant 0.05-0.2% W / v - stabilizer 0.2-3% W / v - water 96-99% W / v with step As follows: a) dissolve losone methyl ether in azone methew ether; b) dissolve anionic polymer in water and add surfactant to mix well; c) dissolve chi. Tosan in acetic acid) lozone methyl ether obtained from step a) dripped into polymer solution obtained from step b) under agitation at rotational speed. 400-1000 rpm for 2-30 minutes e) Then the above mixture obtained from step d) drip into chitosan solution obtained from step c) or drop chitosan solution obtained from step c). Step c) into the mixture obtained from step d) under blending speed 400-1000 rpm for 2-30 minutes f) After that add stabilizer. Under spinning at 400-1000 rpm for 2-30 minutes, the lost-zone methyl ether nanoparticle was dispersed in water. 1. Process for the preparation of losone-methyl ether nanoparticle using polyelectrolyte complexion technique. The steps are as follows. A) dissolve losone methyl ether in losone methyl ether b) dissolve anionic polymer in water and add surfactant to mix well c) dissolve chi Tosan in acetic acid) take the losone methyether solution obtained from step a) drop into the polymer solution obtained from step b) under agitation at 400- 1000 rpm for 2-30 minutes e) Then the above mixtures obtained from step d) drip into chitosan solution obtained from step c) or drop chitosan solution obtained from step c. A) into the mixture obtained from step d) under spin speed 400-1000 rpm for 2-30 minutes f) After that add stabilizer After spinning at 400-1000 rpm for 2-30 minutes, the lost zone methyl ether nanoparticle was dispersed in water.