TH98783A - Aza-indolyl compounds And how to use it - Google Patents

Abstract

DC60 (12/03/52) The invention involves acaindrolyl compounds according to formula I with anticancer and / or anti-inflammatory effects. And more specifically Related to compounds Asaindolyl, which inhibits the activity of MEK kinase, the fabrication provides the composition and method with Useful for inhibiting the abnormal proliferation of cells. Or treatment of disorders about The proliferation, or therapy of inflammatory disease in mammals, also involves methods of using compounds for cell diagnosis or therapy. Of mammals in vitro, in situ, and in vivo, or associated pathological conditions The invention would involve acaindollilyl compounds based on formula I with anti-cancer and / or anti-inflammatory effects. And more specifically Related to compounds Asaindolyl, which inhibits the activity of MEK kinase, the fabrication provides the composition and method with Useful for inhibiting the abnormal proliferation of cells. Or treatment of disorders about The proliferation, or therapy of inflammation in mammals and invention, involves a method of using compounds for diagnosis or cell therapy. Of mammals in vitro, in situ, and in vivo, or associated pathological conditions.

Claims (1)

1. Compounds selected from formula I: (chemical) I and their salts, where: Z1 is CR1 or N; Z2 is CR2 or N; Z3 is CR3 or N; Z4 is CR4 or N; Where one or two of Z1, Z2, Z3, and Z4 are N; R1, R2, R3, and R4 are selected independently of H, Halo, CN, CF3, OCF3, -NO2, - ( CR14R15) nC (= Y) R11, - (CR14R15) nC (= Y) OR11, - (CR14R15) nC (= Y) NR11R12, - (CR14R15) nNR11R12, - (CR14R Tag: drug patent.