TH98294B - Composition and methods for adjusting C-kit receptors - Google Patents
Composition and methods for adjusting C-kit receptorsInfo
- Publication number
- TH98294B TH98294B TH701005283A TH0701005283A TH98294B TH 98294 B TH98294 B TH 98294B TH 701005283 A TH701005283 A TH 701005283A TH 0701005283 A TH0701005283 A TH 0701005283A TH 98294 B TH98294 B TH 98294B
- Authority
- TH
- Thailand
- Prior art keywords
- raf
- remedial
- abl
- adjusting
- composition
- Prior art date
Links
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 title abstract 2
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- -1 PDGRB Proteins 0.000 abstract 2
- 230000002159 abnormal effect Effects 0.000 abstract 2
- 230000000246 remedial Effects 0.000 abstract 2
- 102100000269 AIMP2 Human genes 0.000 abstract 1
- 101700056974 BRK Proteins 0.000 abstract 1
- 108060001945 CRK Proteins 0.000 abstract 1
- 102100005175 CSF1R Human genes 0.000 abstract 1
- 101700063802 CSF1R Proteins 0.000 abstract 1
- 102100006440 CSK Human genes 0.000 abstract 1
- 108060006697 CSK Proteins 0.000 abstract 1
- 108060002883 FES Proteins 0.000 abstract 1
- 102100020191 FGFR3 Human genes 0.000 abstract 1
- 102100004573 FLT3 Human genes 0.000 abstract 1
- 101710009074 FLT3 Proteins 0.000 abstract 1
- 102100013180 KDR Human genes 0.000 abstract 1
- 101700033678 KDR Proteins 0.000 abstract 1
- 101710030888 KDR Proteins 0.000 abstract 1
- 101700033896 LCK Proteins 0.000 abstract 1
- 102100015874 MAP2K4 Human genes 0.000 abstract 1
- 101710027749 MAP2K4 Proteins 0.000 abstract 1
- 102100012607 MAP2K6 Human genes 0.000 abstract 1
- 101710027753 MAP2K6 Proteins 0.000 abstract 1
- 101710029925 MAPK11 Proteins 0.000 abstract 1
- 102100005529 MAPK11 Human genes 0.000 abstract 1
- 101710029924 MAPK8 Proteins 0.000 abstract 1
- 102100005531 MAPK8 Human genes 0.000 abstract 1
- 101710029922 MAPK9 Proteins 0.000 abstract 1
- 102100005528 MAPK9 Human genes 0.000 abstract 1
- 101700062165 MKK4 Proteins 0.000 abstract 1
- 101710038869 MKK6 Proteins 0.000 abstract 1
- 108060005033 NTRK2 Proteins 0.000 abstract 1
- 101710018349 PDGFRA Proteins 0.000 abstract 1
- 102100007292 PTK6 Human genes 0.000 abstract 1
- 101700008308 PTK6 Proteins 0.000 abstract 1
- 108091000081 Phosphotransferases Proteins 0.000 abstract 1
- 102000001253 Protein Kinases Human genes 0.000 abstract 1
- 108010029869 Proto-Oncogene Proteins c-raf Proteins 0.000 abstract 1
- 102100016115 RAF1 Human genes 0.000 abstract 1
- 101710009878 RPS6KB1 Proteins 0.000 abstract 1
- 102100011601 RPS6KB1 Human genes 0.000 abstract 1
- 102000001332 SRC Human genes 0.000 abstract 1
- 101710009384 SRC Proteins 0.000 abstract 1
- 102100014320 TGFB1 Human genes 0.000 abstract 1
- 101700041213 TGFB1 Proteins 0.000 abstract 1
- 108010081267 Type 3 Fibroblast Growth Factor Receptor Proteins 0.000 abstract 1
- 229940045988 antineoplastic drugs Protein kinase inhibitors Drugs 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 102000017256 epidermal growth factor-activated receptor activity proteins Human genes 0.000 abstract 1
- 108040009258 epidermal growth factor-activated receptor activity proteins Proteins 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000003909 protein kinase inhibitor Substances 0.000 abstract 1
- 230000001225 therapeutic Effects 0.000 abstract 1
Abstract
การประดิษฐ์ จะให้สารประกอบ และ องค์ประกอบในทางเภสัชกรรมของมัน, ซึ่ง มีประโยชน์เป็นสารยับยั้งโปรตีน ไคเนส, รวมทั้งวิธีการสำหรับการใช้สารประกอบดังกล่าวในการ รักษา, การเยียวยา หรือ การป้องกันสภาวะที่สัมพันธุ์กับไคเนส แอคตีวิตี้ที่ผิดปกติ หรือ ไม่ถูกกำกับ ควบคุม ในบางรูปแบบ, การประดิษฐ์จะให้วิธีการสำหรับการใช้สารประกอบดังกล่าวเพื่อการรักษา, การเยียวยา หรือ การป้องกันโรค หรือ ความผิดปกติที่มีส่วนเกี่ยวข้องกับการแอคติเวชั่นที่ผิดปกติ ของ c-kit, PDGFRa, PDGRB, CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGFB, SRC, EGFR, trkB, FGFR3, FLT3, Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2B, BRK, KDR, c-raf หรือ b-raf ไคเนส, หรือ รูปฟอร์ม มิวแตนท์ของมัน The invention provides compounds and their pharmaceutical constituents, which are useful as protein kinase inhibitors, as well as a means for their use in the treatment, remedial or prevention of conditions associated with chi. Nest Abnormal or unregulated activity, in some ways, the invention provides a means for the use of the compound for therapeutic, remedial, or prophylactic purposes or associated with Abnormal activity of c-kit, PDGFRa, PDGRB, CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGFB, SRC, EGFR, trkB, FGFR3, FLT3, Fes, Lck. , Syk, RAF, MKK4, MKK6, SAPK2B, BRK, KDR, c-raf or b-raf kinase, or its mutant form.
Claims (1)
Publications (2)
Publication Number | Publication Date |
---|---|
TH98294A TH98294A (en) | 2009-09-17 |
TH98294B true TH98294B (en) | 2009-09-17 |
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TH98294A (en) | Composition and methods for adjusting C-kit receptors |