TH94331B - Sulfur-containing pyrazole derivative, CB1 selective antagonist receptor antagonist. - Google Patents
Sulfur-containing pyrazole derivative, CB1 selective antagonist receptor antagonist.Info
- Publication number
- TH94331B TH94331B TH701002625A TH0701002625A TH94331B TH 94331 B TH94331 B TH 94331B TH 701002625 A TH701002625 A TH 701002625A TH 0701002625 A TH0701002625 A TH 0701002625A TH 94331 B TH94331 B TH 94331B
- Authority
- TH
- Thailand
- Prior art keywords
- compounds
- sulfur
- pyrazole derivatives
- antagonist
- pyrazole derivative
- Prior art date
Links
- 229910052717 sulfur Inorganic materials 0.000 title claims abstract 3
- 150000003217 pyrazoles Chemical class 0.000 title abstract 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 title abstract 2
- 239000011593 sulfur Substances 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 6
- 239000000126 substance Substances 0.000 claims abstract 2
- 150000003457 sulfones Chemical class 0.000 claims 2
- 150000001204 N-oxides Chemical class 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229930003827 cannabinoid Natural products 0.000 abstract 1
- 239000003557 cannabinoid Substances 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Abstract
การประดิษฐ์ครั้งนี้จะเกี่ยวข้องกับอนุพันธ์ไพราโซลที่มีซัลเฟอร์, และ เหล่า S- ออกซิไดซ์ แอคทีฟ เมตาบอไลท์, ในรูปแคนนาบินอยด์ CB, รีเซปเตอร์ แอนทาโกนิสท์เลือกจำเพาะ ที่ทีสภาพเลือกเฉพาะสูงต่อประเภทย่อย C1/BCB2 รีเซปเตอร์ , เกี่ยวข้องกับวิธีการสำหรับการ จัดเตรียมสารประกอบเหล่านี้, กับสารมัธยันตร์ตัวใหม่ที่เป็นประโยชน์สำหรับการสังเคราะห์ อนุพันธ์ไพราโซลดังกล่าว, กับสารผสมในทางเภสัชกรรมที่ประกอบรวมด้วยหนึ่งหรือหลาย อนุพันธ์ไพราโซลเหล่านี้เป็นองค์ประกอบออกฤทธิ์, รวมทั้งการใช้สารผสมในทางเภสัชกรรม สำหรับการรักษาความผิดปกติทางจิตเวช และ ทางประสาทวิทยา โดยสารประกอบจะมีสูตรทั่วไป (I) (สูตรเคมี) (I) โดยที่ สัญลักษณ์จะมีความหมายดังที่ได้ให้ไว้ในรายการจำเพาะ This invention involves sulfur-containing pyrazole derivatives, and S-oxidized active metabolites, as cannabinoid CB, receptors antaco. Nist choose specific Where the highly selective condition per subtype C1 / BCB2 receptor, involves a method for Provides these compounds, with new chemical compounds useful for synthesis. Such pyrazole derivatives, with pharmaceutical mixtures consisting of one or more These pyrazole derivatives are active constituents, including their use in pharmaceuticals. For the treatment of psychiatric and neurological disorders Compounds have the general formula (I) (chemical formula) (I), where the symbol has the meaning given in the specific list.
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH94331A TH94331A (en) | 2009-03-13 |
| TH94331B true TH94331B (en) | 2009-03-13 |
Family
ID=
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