TH94331A - Sulfur-containing pyrazole derivative, which is cannabinoid CB1, selective antagonist receptor antagonist. - Google Patents

Abstract

DC60 This invention involves sulfur-containing pyrazole derivatives, and S-oxidized active metabolites, in the cannabinoid CB1 receptor antaco. Nist choose specific With highly selective conditions per subtype CB1 / CB2 receptor, involves a method for Provides these compounds, with new chemical compounds useful for synthesis. Such pyrazole derivatives, with pharmaceutical mixtures consisting of one or more These pyrazole derivatives are active constituents, including their use in pharmaceuticals. For the treatment of psychiatric and neurological disorders Compounds have the general formula (I) (chemical formula) (I), where the symbol has the meaning given in the specific list. This invention involves sulfur-containing pyrazole derivatives, and S-oxidized active metabolites, as cannabinoid CB, receptors antaco. Nist choose specific Where the highly selective condition per subtype C1 / BCB2 receptor, involves a method for Provides these compounds, with new chemical compounds useful for synthesis. Such pyrazole derivatives, with pharmaceutical mixtures consisting of one or more These pyrazole derivatives are active constituents, including their use in pharmaceuticals. For the treatment of psychiatric and neurological disorders Compounds have the general formula (I) (chemical formula) (I), where the symbol has a meaning as given in the drug patent specification.

Claims (1)

1. Compounds of the formula (l) (chemical formula) (l) where - R1 denotes H, Cl or Br, - R2 denotes Cl or Br, - X represents the sulfur atom, suloxide (S = O ) Or sulfone (SO2) moity, -Y denotes methyl or ethyl group, - n can be 1, 2 or 3, and toomer, stereo isomer, , Pro-drac and its N-oxides, and formula compounds (l) are labeled with isotope compounds, including salts, hydrates and solvents of formula compounds (l). Tag: drug patent.