TH87764A - Dosage pattern of 1 time per day of Paramipec Sol - Google Patents

Abstract

DC60 (24/10/46) Orally Deliverable Pharmaceutical Mixture containing Pramipec Seoul and Pharmacokinetically tolerable amounts of oily salts in the therapeutic effect and at least 1 chemically acceptable exocrine, at least one of the above ingredients has been shown (a). Discharge in a test tube Where the average solubility of pramipexol does not exceed approximately 20% within 2 hours after placing the mixture in the standard solubility test; And (b) absorption scheme Of pramipexol in organisms followed by dosing as a healthy adult human. Where the time to mid-absorption at 20% was greater than approximately 2 h, and / or the time to mid-absorption at 40% was greater than approximately 4 h. For oral administration, not more than 1 time per day to subjects with conditions or abnormalities. From indications of dopamine receptor agonist An oral deliverable pharmaceutical mixture containing: Pramipec Seoul and Pharmacokinetically tolerable amounts of oily salts in the therapeutic effect and at least 1 chemically acceptable exocrine, at least one of the above ingredients has been shown (a). Discharge in a test tube Where the average soluble pramipexol did not exceed approximately 20% within 2 hours after laying the mixture in a standard two-solubility agent, and (b) the bioavailability scheme. Of pramipexol in organisms followed by dosing as a healthy adult human. Where the time to mid-absorption at 20% was approximately 2 hours and / or the time to the mid-absorption at 40% was approximately 4 hours. For oral administration, not more than 1 time per day to subjects with conditions or abnormalities. From indications of dopamine receptor agonist

Claims (1)

: DC60 (24/10/46) An oral deliveryable pharmaceutical mixture containing Pramipec Seoul and Pharmacokinetically tolerable amounts of oily salts in the therapeutic effect and at least 1 chemically acceptable exocrine, at least one of the above ingredients has been shown (a). Discharge in a test tube Where the average solubility of pramipexol does not exceed approximately 20% within 2 hours after placing the mixture in the standard solubility test; And (b) absorption scheme Of pramipexol in organisms followed by dosing as a healthy adult human. Where the time to mid-absorption at 20% was greater than approximately 2 h, and / or the time to mid-absorption at 40% was greater than approximately 4 h. For oral administration, not more than 1 time per day to subjects with conditions or abnormalities. From indications of dopamine receptor agonist An oral deliverable pharmaceutical mixture containing: Pramipec Seoul and Pharmacokinetically tolerable amounts of oily salts in the therapeutic effect and at least 1 chemically acceptable exocrine, at least one of the above ingredients has been shown (a). Discharge in a test tube Where the average soluble pramipexol did not exceed approximately 20% within 2 hours after laying the mixture in a standard two-solubility agent, and (b) the bioavailability scheme. Of pramipexol in organisms followed by dosing as a healthy adult human. Where the time to mid-absorption at 20% was approximately 2 hours and / or the time to the mid-absorption at 40% was approximately 4 hours. For oral administration, not more than 1 time per day to subjects with conditions or abnormalities. From indications of dopamine receptor agonist (Item one) which will appear on the advertisement page: edit 26/10/2015 1. Slow release composition Once a day pharmaceutical deliverable by mouth which Including Pramipec Seoul Dihydrochloride Monohydrate approx. 0.1 to approx. 10 mg, Starch by approx. 25% to approx. 75% by weight, Hydrophobic polymers approx. 20% to approx. 70% by weight, where Prami The pecsol is propagated in hydrophilic and starchy polymers and acts of such hydrophobic polymers to provide the slow release of the loud pramiplex sol. In other words, such elements are displayed at least six tags: