TH86642B - The derivative of 5-piridyl-1-azabicyclone [3.2.1] octane. Preparation of the substance and its use - Google Patents
The derivative of 5-piridyl-1-azabicyclone [3.2.1] octane. Preparation of the substance and its useInfo
- Publication number
- TH86642B TH86642B TH601003813A TH0601003813A TH86642B TH 86642 B TH86642 B TH 86642B TH 601003813 A TH601003813 A TH 601003813A TH 0601003813 A TH0601003813 A TH 0601003813A TH 86642 B TH86642 B TH 86642B
- Authority
- TH
- Thailand
- Prior art keywords
- alkyl
- amino
- octane
- thiazoleil
- azabicyclone
- Prior art date
Links
- 239000000126 substance Substances 0.000 title claims abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract 4
- -1 Cyano, Hydroxyl Chemical group 0.000 claims abstract 3
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 125000002883 imidazolyl group Chemical group 0.000 claims abstract 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims abstract 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- ZLTPDFXIESTBQG-UHFFFAOYSA-N isothiazole Chemical compound C=1C=NSC=1 ZLTPDFXIESTBQG-UHFFFAOYSA-N 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Abstract
การประดิษฐ์เกี่ยวกับสารประกอบที่มีสูตรทั่วไป (I) (สูตรเคมี) (I) ซึ่ง R แสดงแทนหมู่ที่เลือกจากไพราโซลิล, อิมิดาโซลิล, ไทรอะโซลิล, ออกซะโซลิล, ออกซะไดอะโซลิล, ไธอะโซลิล, ไอโซไธอะโซลิล, ไธอะไดอะโซลิล, และ เททระโซลิล, หมู่นี้อาจถูก แทนที่ด้วยหนึ่งหมู่หรือมากกว่าที่เลือกจากแฮโลเจนอะตอม และหมู่ (C1-C6)แอลคิล, (C1-C6)แอลคอกซิ, ไทรฟลูออโรเมธอกซิ, ไทรฟลูออโรเมธิล, ไนโตร, ไซยาโน, ไฮดรอกซิล, อะมิโน (C1-C6)แอลคิลอะมิโน และได(C1-C6) แอลคิลอะมิโน; พันธะคาร์บอน-คาร์บอน ระหว่าง ตำแหน่ง 3 และ 4 ของวงอะซาไบไซโคลออกเทนคือ พันธะเดี่ยวหรือพันธะคู่; ในรูปของเบสหรือ เกลือที่เกิดจากการรวมตัวกับกรด และในรูปของไฮเดรต หรือโซลเวตด้วย กรรมวิธีการเตรียม และการใช้รักษาโรค The invention of a compound with the general formula (I) (chemical formula) (I), where R represents the selected group from pyrazolyl, imidazolyl, triazolin, oxasolil. , Oxadiazoleil, thiazoleil, isothiazoleil, thiazoleil, and tetrazolil, among these may be Replace with one or more groups selected from halogens, atoms and clusters (C1-C6) alkyl, (C1-C6) alkyl, trifluoromethoxy, trifluorome. Thyl, Nitro, Cyano, Hydroxyl, Amino (C1-C6) Lkyl Amino and Di (C1-C6) Lkyl Amino; The carbon-carbon bond between positions 3 and 4 of the azabiclooclo-octane loop is Single bond or double bond; In the form of a bass or Salts formed by combining with acids And in the form of hydrates Or solvette too Preparation process And therapeutic use
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH86642B true TH86642B (en) | 2007-09-20 |
| TH86642A TH86642A (en) | 2007-09-20 |
Family
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