TH82154A - New pyridothione pyrimidine derivatives - Google Patents

Abstract

DC60 (23/02/49) Pyridothienopyrimidine derivatives of formula (I); (chemical formula) (I) and pharmaceutically accepted salts and their N-oxides, which are potent and selective inhibitors of PDE4 and are useful in the treatment, prevention or inhibition of pathological conditions, diseases and disorders known to be susceptible to amelioration by PDE4 inhibition, in particular asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, atopic dermatitis, psoriasis or irritable bowel syndrome. Pyridothienopyrimidine derivatives of formula (I); (chemical formula) (I) and pharmaceutically accepted salts and their N-oxides, which are potent and selective inhibitors of PDE4 and are useful in the treatment, prevention or inhibition of pathological conditions, diseases and disorders known to be susceptible to amelioration by PDE4 inhibition, in particular asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, atopic dermatitis, psoriasis or irritable bowel syndrome. Pathologically, diseases and disorders known to be sensitive to improvement by PDE4 inhibition, particularly asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, atopic dermatitis, psoriasis, or irritable bowel syndrome.

Claims (1)

1. The use of pyridothienopyrimidine derivatives of formula (I) (chemical formulas) and chemically acceptable salts and N-oxides of them, where G1 represents the selected group from -CR6R7- or -NR6, with R6 and R7 independently selected from atoms. Hydrogen and C1-4 alkyl groups m and n are integers selected from 0 or 1. R1 and R2 are independently selected from hydrogen atoms and C1-4 alkyl groups R3 representing the selected group from alkyls. , Amino, Monol, Tag: Drug Patent