TH80756A - Phenylpiperazine derivatives with combination of parabolic dopamine-D2 receptor agonism and inhibition of serotonin reabsorption. - Google Patents

Abstract

DC60 (28/02/49) An invention concerning a group of novel phenylpiperazine derivatives with a dual mode of action: inhibition of serotonin reabsorption and partial aggonism on the dopamine-D2 receptor. The invention also concerns the use of the compounds revealed herein for the production of pharmaceuticals that yield beneficial results. The compounds have the general formula (1): (chemical formula) (1), the symbols of which are given in detail, and totomers, stereoisomers and N-oxides of them, as well as the pharmacologically accepted salts, hydrates and solves of such compounds of formula (1) and totomers, stereoisomers and N-oxides of them. An invention concerning a group of novel phenylpiperazine derivatives with a dual mode of action: inhibition of serotonin reabsorption and partial aggonism on the dopamine-D2 receptor. The invention also concerns the use of the compounds revealed herein for the production of pharmaceuticals that yield beneficial results. The compound has a general formula (1): (chemical formula) (1), the symbols of which are given in detail, and the totomers, stereoisomers and N-oxides of them, as well as the pharmacologically accepted salts, hydrates and solves of such compounds of formula (1) and their totomers, stereoisomers and N-oxides.

Claims (1)

1. Compounds of the general formula (1): (chemical formula) (1) where: X = S or O, R1 is H, (C1-C6) alkyl, CF3, CH2CF3, OH or O- (C1-C6. ) R2 alkyl is H, (C1-C6) alkyl, halogen or cyano R3 is H or (C1-C6) alkyl R4 is H, (C1-C6) L. The kill, selected to be replaced by halogen T atoms, is a 2-7 carbon chain that is either saturated or unsaturated, where one carbon atom may be replaced With selected nitrogen atom. Tag: drug patent